[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])N=C(O1)N([H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]C1=C(Br)C([H])=C2C(=N1)[C@@]([H])(C1=C(C([H])=C(Cl)C([H])=C1Br)C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2SSC([H])([H])C([H])([H])N([H])C1=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]C([H])=C([H])C([H])([H])N1C(=C([H])C(C(=O)C([H])([H])OC2=C(N=C(C([H])=C2[H])C([H])([H])[H])[N+]([O-])=O)=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O1 [H]N(C1=NN([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])N=C(C#N)C(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[P@](=O)(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])(F)F)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C2=NC([H])([H])C([H])([H])N2[H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])N1C([H])=C(C(=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#CC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C2[H])[N+]([O-])=O)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(F)=C([H])C([H])=C1F)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC1=C(F)C(=C([H])C([H])=C1[H])C1=C([H])N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1C(F)(F)F [H]S\C(=N/C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]1([H])N([H])C(=NC2=C1C1(C(=O)N2[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])Br)[C@@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]3([H])C([H])([H])C([H])([H])C(=O)[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])N2C([H])([H])C(F)(F)F)C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC1=NC([H])=C(C([H])=C1Cl)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)\N=C(/C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C(C([H])=C([H])C([H])=C1[H])N(C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C2=NC(=C([H])C(=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(I)N=C12)N([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] CCCC[Sn](CCCC)(CCCC)C1=CC(Cl)=C(NC2=NC(C)=NC(N(CCC)CC3CC3)=C2Cl)C(Cl)=C1 [H]OC1=C(Br)C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C3S2(=O)=O)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]N(C(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N([H])C([H])([H])[H])[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])N([H])C2=C(C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])S1(=O)=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])N=C([H])C([H])=C1OC1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])O[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N2N=NN=C12)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C#N)C(SC([H])([H])[H])=NS1 [H]OC([H])([H])[C@]1(OC(=O)\C(=C(/[H])C([H])([H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=S)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC(=N2)C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C([H])C(=N2)N2C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C2=NC([H])=C([H])C(OC([H])([H])C3=NN=C4N=C([H])C(=NN34)C3=C([H])C([H])=C(F)C([H])=C3[H])=C2S1 [H]ON([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C([H])N=C(OC([H])([H])C([H])([H])N3C(=O)C([H])([H])C([H])([H])C3([H])[H])C([H])=C12)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=C2C([H])=NN([H])C2=C1[H])C1=C([H])N=C([H])C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)S(=O)(=O)C1=C2C([H])=C([H])C([H])=C3C(=O)N([H])C(C([H])=C1[H])=C23 [H]N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N([H])C(=O)C1(C2=C([H])C([H])=C([H])C(SC3=C([H])C([H])=C(C([H])=C3[H])N3N=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C(F)=C3[H])C([H])([H])[H])N(C3=C(Cl)N=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])N=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C(N=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C(F)(F)F [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N=C1[H])N([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C(Cl)=C(OC4=C([H])C([H])=C([H])C(Cl)=C4[H])C([H])=C3[H])=C12 [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C1=NC([H])=C(Cl)C([H])=C1\C([H])=C(/[H])C1=NC([H])=C([H])C([H])=C1[H] [H]C([H])=C(C1=C([H])C([H])=C([H])C(=C1[H])C(N([H])C(=O)N([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=NC2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])S[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N1C(=O)C2=C(N=C1[C@]([H])(N1C([H])([H])C([H])(OC3=C([H])C([H])=C(F)C([H])=C3[H])C1([H])[H])C([H])([H])[H])N(N=C2[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N2C(=NC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C2=C(OC3=C2C([H])=C(Cl)C([H])=C3[H])C(=O)N(C1=S)C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] ClC1=CC=CC(NCN2N=C(OC2=S)C2=NC3=CC=CC=C3C=C2)=C1 [H]N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)SC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C1C1=C(C([H])=C2[H])C2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C2=C1C(=O)N([H])C2=O [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3S2)C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C([H])C2=C(C([H])=C1[H])N1C(=C(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]2([H])N(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N1C(=O)C2=NN(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])N2C2=C1C([H])=C([H])C([H])=C2[H] [H]N(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=C(C([H])=C3N=N2)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C(C3=C([H])C4=C(OC([H])([H])C([H])([H])O4)C([H])=C3N=C12)C([H])([H])[N+]1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]C1=C(C(=NN1C([H])([H])C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(OC1=C([H])N(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(\N=C1\C2=C(N([H])C3=C2C([H])=C(Cl)C([H])=C3[H])C(=O)N([H])C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C([H])N=C1[H] [H]N1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C(C(=O)OC([H])([H])[H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])[C@@]([H])(C2=C([H])C(F)=C(F)C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C1C([H])([H])[H] [H]O[C@]1(C2=C([H])N([H])N=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H])N([H])[H] [H]N([H])C(=NC(=O)C1=C(N([H])[H])C([H])=C(O1)C1=C(F)C([H])=C([H])C([H])=C1[H])N([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C(C1=O)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C([H])C([H])=C23)C(=N1)C1=C([H])C([H])=C(O1)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] FC(F)(F)C1=CC=C(NC2=CC(=NC=N2)C2=CC=NC=C2)C=C1 [H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C1=NC(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C#N)C(=C1[H])C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C([H])C([H])=C1[H] COC1=CC=C2N(C(=CC2=C1)S(=O)(=O)N1CCC(CNS(=O)(=O)C(F)(F)F)CC1)S(=O)(=O)C1=C(F)C=CC=C1 [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C1=C(C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C2([H])[H] [H]N1C2=C(C([H])=C(S2)C([H])([H])[H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C(=C([H])C([H])=C1[H])N1N=NN=C1[H] [H]N([H])C1=C(C([H])=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1C2=O)S([O-])(=O)=O [H]C1=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2F)=C2C(OC([H])([H])C(=O)N(C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C2([H])[H])=N1 [H]C1=C(Br)N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C1=C(C(=O)N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(C(N2C3=C(C(=C2C([H])([H])[H])C([H])([H])[H])C(=NC(=N3)C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C2([H])C([H])([H])C2([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C(=O)C([H])([H])[H])C(O[H])=C2[H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=N[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@@]2([H])C1=O)C([H])([H])[H] [H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C1=C([H])C(=O)[C@@](O1)(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C2C([H])=C(N=C([H])C2=NC([H])=N1)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C1=NOC2=C([H])C([H])=C(C([H])=C12)N1N=C(C2=C([H])C([H])=C(C(F)=C12)C1=C(F)C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C(OC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])SC(=N1)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C2C([H])=C([H])C2=C3OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])SC1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])[C@@]1(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]2([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C([H])=N2)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=NC2=NC([H])=C([H])C([H])=C2C1=O [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]\C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)N([H])C2=NC([H])=C([H])C([H])=C2[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])N1C(=NC2=C1C([H])=C([H])C([H])=N2)C([H])([H])[H] [H]N(C1=NC2=C(S1)N=C(N=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=NSC(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(OC1=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C13)C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H] [H]C([H])([H])C(OC(=O)N1[C@@]([H])(C(=O)N2C([H])([H])SC([H])([H])C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1Cl [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N(C3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C2=C(C(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C(N=C2C([H])([H])[C@]2(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(ON=C1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C(O[H])=C1[H])C(=O)C(=C([H])O2)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]\C(=C(\[H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)O2)C([H])=C1[H])C1=C([H])C(=O)C(O1)(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1OC(=O)[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(F)C(=C([H])C([H])=C1[H])C1=C(N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F)C([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C2=C(N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(I)=C([H])C([H])=C2C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2[C@@](OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(C#N)=C1[H] [H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C([H])C([H])=C(C([H])=C3C3=C2C2=C(C4=C(C([H])=C([H])C(=C4[H])C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H])N2C1([H])[H])C1=C3C([H])([H])N([H])C1=O)C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C3N=C([H])C([H])=C([H])C3=C([H])C([H])=C2C2=C([H])C(=C([H])C([H])=C2S1(=O)=O)C(F)(F)F [H]N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2F)C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])SC2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])=NC([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])C1=C2C(C([H])=C([H])C([H])=C2C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C(OC(=N1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(N([H])\N=C(/C(/[H])=C(/N([H])N([H])C(N([H])[H])=[N+]([H])[H])C([H])([H])[H])\C([H])([H])[H])=[N+]([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC([H])([H])[C@]([H])(N([H])C1=C(C2=NC3=C(N2[H])C(=C([H])C([H])=C3C([H])([H])[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C(=O)N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C([H])=C1[H])C([H])([H])C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]N(C1=C2N=C(N(C2=NC(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1O[H] CC1=NN=C2CCC3=C(C=C(Cl)C(=C3)C3=CN=CC4=CC=CC=C34)N12 [H]N=C(N([H])[H])C1=C([H])C(=C([H])C(N([H])[H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])N([H])C(=O)C([H])([H])[N+]2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] C[C@]1(CCOC(N)=N1)C1=CC(NC(=O)C2=NC=C(Cl)C=C2)=CC=C1F [H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])[C@]1([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C(SC([H])([H])C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C([H])([H])N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C(=N2)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(N=C1[H])N([H])C(N([H])[H])=[N+]([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(\C([H])=C2/N([H])C(=O)\C(N([H])C2=O)=C(/[H])C2=C([H])C([H])=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S2)C([H])=C1[H] [H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(C#N)=C(OC([H])([H])[H])C([H])=C1[H] COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CN=CC(=C3)C3=NNC=C3)C2=O)C=C1 [H]N(C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C2C([H])=C(N([H])C([H])([H])C3=C([H])N=C4C([H])=C([H])C([H])=C([H])N34)C([H])=C(Cl)C2=NC([H])=C1C#N [H]O[C@]([H])(C1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C(C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[H])S2(=O)=O)C([H])([H])[H] [H]O[C@@]([H])([C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H])[C@]1([H])N([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C(F)=C([H])C([H])=C4[H])C(Cl)=C3[H])C2=C1[H] [H]OC1=C([H])C(=C([H])C(F)=C1[H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(O[H])C(F)=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])N(C(=O)C([H])([H])[H])C2([H])[H] [H]OC([H])([H])C1=C(N=C([H])C(=C1[H])C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(O[C@@]3(C2([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1C([H])([H])C([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NSC(SC([H])([H])[H])=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)C1=CC=CC=C1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=C(C([H])=C([H])S1)C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C2=NC([H])=NC(N([H])[H])=C12)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl [H]C1=C(Br)OC(=C1[H])C1=NOC(=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])C2=C([H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N([H])[C@]([H])(C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C#CC([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C(C([H])=C(Br)C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=NC([H])=C2[H])=C1C([H])([H])[H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])[H])C1=C([H])C(=O)N([H])O1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C#N)C(Cl)=NC(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C#N [H]N(C1=NC([H])=NC2=C1C([H])=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])[H])N(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C(=C([H])C([H])=C2[H])C1=C(F)C2=C(N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])\C2=N/OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1F [H]N([H])S(=O)(=O)C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])SC(=S)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=NC([H])=C1[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1 [H]C1=C(N(C2=NC(=NC(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C1=NC(=C([H])S1)C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])SC(=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2[H])C([H])=C1[H])C([H])=O [H]OC1(C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C(C#N)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])OC([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C2=C(C3=C1C(=S)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C3([H])[H])C(F)=C([H])C(F)=C2[H] [H]C1=C(N(C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=N1)C([H])([H])[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C(SC([H])([H])C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H])=NC2=C([H])C(F)=C([H])C([H])=C12 [H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C(=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])[C@]1([H])C([H])([H])N(C(=O)[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2N(C(=N3)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])N(N=C2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C(OC([H])([H])[H])=C2C([H])=C([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[H] [H]N([H])C(=O)C(=O)C1=C2N(C([H])=C([H])C([H])=C2OC([H])([H])C(=O)OC([H])([H])[H])C(=C1C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C([H])N(C(=N1)C1=C([H])C(=NC2=C(OC([H])([H])C3=C(Cl)C([H])=NC([H])=C3Cl)C([H])=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])N1C2=C(N(C(=N2)C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C(=O)N(C([H])([H])[H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])[N+]([O-])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=CC=C(C(=O)N[C@@H]2C[C@@H](N(C2)S(=O)(=O)C2=CC=C(Cl)C(Cl)=C2)C(=O)NO)C(OC)=C1 [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1N=C(C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]11C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C2=NN=C(O2)C([H])([H])[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])N(C(=O)C1=C(N=C2N1C([H])([H])C([H])([H])N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])OC1=C2N=C([H])N([H])C2=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)O2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])S2(=O)=O)C([H])([H])C1([H])[H] CO[C@@H]1CC[C@H]1CNC1=C2C(NC(=C2C2=CC=CC=C2)C2=CC=C(OCCN(C)C)C=C2)=NC=N1 [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(N([H])C(=O)C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(F)C([H])=C3[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N2C(=NN=C2C(F)(F)F)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N(C1=C([H])C(=NC([H])=N1)C1=C([H])SC(=N1)N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(Cl)C([H])=C(Cl)N=C2C([H])=C1[H])C(=O)O[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(Br)C([H])=C(\C([H])=C2/C(=O)N([H])C3=NC([H])=C(Br)C([H])=C23)C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]1([H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC2(C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=NC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F C(CSC1=NN=C(O1)C1=CC=NC=C1)CN1CCCCC1 [H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC2=C(N=C([H])N=C12)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4[H])C([H])=C([H])C(=C5[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C2C([H])=C([H])C2=C3OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(ON=C2C2=C(O[H])C(=C(O[H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])C([H])=C([H])S1)C2(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=O)C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C([H])C([H])=C1F [H]N(C(=O)C1=C([H])C(Cl)=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])=C([H])[C@@]2([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(C([H])=C([H])C(N([H])C([H])([H])[H])=C4O[C@@]12[H])C3([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C([H])=C([H])C(C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(=N/C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])N(C2=C(C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=NN=NN1[H] COC[C@H]1OC(OCCC2=CC=CC=C2)[C@H](NCCN)C(OCC2=CC3=CC=CC=C3C=C2)[C@@H]1O [H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC(=N1)N1C([H])=NC([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C2([H])C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C(=O)O[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)C([H])=C2[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])C(=C([H])[C@@]23[H])C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])F [H]N1C([H])=NC([H])=C1C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(=O)N(C2=C3C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])N(C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=NC([H])=C2C([H])=NN(C2=N1)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])[C@]2([H])C1([H])[H] [H]O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1=C(N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C(I)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N([C@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2F)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1 [H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C1([H])[H] [H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] COC1=CC(NC2=C3C=NN(C)C3=NC(=N2)N2CCC(O)CC2)=CC=C1 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(O1)C1=NC(=NO1)C1=NC([H])=C(Cl)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])(N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])O[H] [H]N(C(=O)C([H])([H])[H])C1=NC(=C(S1)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC(=C1\C([H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])N([H])C(\S[H])=N\C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1([H])C2=C(O[C@]3(C([H])([H])C([H])([H])C3([H])[H])C1([H])[H])N=C([H])C(=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N(C(=O)C([H])([H])[C@]([H])(C2=C([H])C(Br)=C([H])C([H])=C2[H])[C@]1([H])[N+]([O-])=O)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C(Br)O1)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2N=C(OC2=C1[H])C1=C([H])C([H])=C([H])C(O[H])=C1O[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1=O [H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@]1(OC([H])([H])[H])[C@]1([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]21C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]3([H])C5([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(O[C@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C([H])C(F)=C1[H]