[H]N([H])C1=C2C(=NC([H])=N1)N(C([H])=C2C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(SC([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N(N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl CN1N=C(C2=C1C=C(F)C=C2)C1=NC2=C(NC=C2C(=O)N[C@H]2COC[C@@H](N)C2)N=C1 [H]N1N=C([H])C(=C1[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(SC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H] [H]C1=NC(=C(N1C1=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])P1(=O)OC([H])([H])C([H])([H])C([H])([H])O1)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C(=C([H])C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])O1 [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)C2=C([H])C([H])=C3C([H])=C([H])N(C3=C2[H])C([H])([H])[H])C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C1(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@](N([H])C(=O)O[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C2C(SC3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])N([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C5=C([H])C([H])=C([H])C([H])=C45)C([H])([H])C3([H])[H])C(=O)[C@@]21[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])C2([H])[H])C([H])([H])N([H])[C@]1([H])C(=O)N1C([H])([H])C([H])=C(C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C#N)C1=C(Cl)C([H])=C([H])N=C1N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C1=NN=NN1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N1C(=O)N(C(=O)[C@]1([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O\C(N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])=C1\C(=O)N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3Cl)C3=C(N=C([H])C([H])=C3N2C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=NC2=C1C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C21)C1=NC([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N(N([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]1(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=N1)C([H])=C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C(N([H])C2=C([H])C([H])=NC3=C([H])C(Cl)=C([H])C([H])=C23)=C1[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C(Cl)C(=C1[H])C1=NOC(=N1)C1([H])C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N(C1=NC(=NC2=C(C#N)C([H])=NN12)N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C#CC1=C([H])C([H])=C2SC3=C(N=C(N([H])C3=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)OC1=C2O[C@@]3([H])[C@@]([H])(O[H])C([H])=C([H])[C@@]4([H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34[C@@]2([H])[C@]([H])(C([H])=C1[H])C5([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])F)C1(C(=O)N([H])C(=O)N([H])C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[C@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]C1=C([C@]([H])(OC([H])([H])[H])O[C@]1([H])OC([H])([H])[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C4=C([H])C(=NN4C([H])([H])[H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)[C@@]([H])(OC(=O)N([H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(C2=NC(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N1C(=N[H])C([H])=C([H])C2=NC(C3=C([H])C([H])=C(C([H])=C3[H])C3(N([H])[H])C([H])([H])C([H])([H])C3([H])[H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] OC(CNCCOCCOCCNC(=O)CCCCCNC(=O)COC1=CC=C(\C=C\C2=CC=C3C=C4C=CC(C5=CC=CS5)=[N+]4[B-](F)(F)N23)C=C1)COC1=CC=CC2=C1C=CN2 [H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1F [H]N(\C(=N\C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])C1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H] [H]O[C@]1([H])C2=C(C(=O)C([H])([H])[C@@]3(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(C([H])([H])[H])[C@]2([H])C1([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)C([H])([H])N2C(=O)[C@@]([H])(N([H])S(=O)(=O)C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C(N=C2N1C1=C(C([H])=C([H])C([H])=C1[H])N2C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3N1C([H])([H])[H])C1=C2C(=O)N([H])C1=O [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C(=C(Cl)C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])O2)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C(=C([H])[H])C([H])([H])[C@@]1([H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(N=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1F [H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C([H])([H])F)[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]([H])(C([H])([H])N1C(=O)N(C([H])([H])[H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C2([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3I)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(\C([H])=C(\[H])C(=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C(F)(F)F)=C2[H])C1([H])[H] [H]OC1=C([H])C(OC([H])([H])[H])=C([H])C2=C1C(=O)C([H])=C(O2)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])S(=O)(=O)N([H])[H] [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)C1=NC2=C(O1)N=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2N(C1=O)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H] [H]C1=C(Cl)C(=C([H])C(Cl)=C1SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C(=C([H])C2=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C#N [H]OC(=O)C([H])([H])OC1=C(C([H])=C(OC([H])([H])C2=NC(=C([H])C(=N2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=N[C@](C2=NC([H])([H])C([H])([H])C([H])([H])N12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C2C([H])=C([H])C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C(F)(F)F [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H] [H]N(C1=N\C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)=C1/C([H])=C([H])C([H])=C([H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]ON(C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C([H])C([H])=C3N2[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C(S2)C2=NC([H])=C(O2)C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2=NC3=C(OC4=C3C([H])=C(Br)C([H])=C4[H])C(=O)N2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C#CC([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NC([H])=C([H])C([H])=N1)C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1I)[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N([H])C([H])(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=NN(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C([H])([H])[C@@]2([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C(C#N)C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C(N=N2)C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])SC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=N1 [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Br [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(=O)N([H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C(I)SC2=C1C(=N[C@]([H])(C1=NN=C(N21)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])S(=O)(=O)C1=C([H])N=C([H])C([H])=C1N([H])N([H])C1=NS(=O)(=O)C2=C(S1)C([H])=C(Cl)C(C#N)=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C(=N[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] CN1CCN(CC1)[C@@H]1CC[C@@H](CC1)N1N=C(C2=C1N=CN=C2N)C1=CC=C(NC2=NC3=C(O2)C=CC=C3)C=C1 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H])C1=NN=C(O1)C1=C([H])C([H])=C([H])S1 [H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] CC1=C2N=C(C3=CC=CC=C3F)C3=C(NC2=NN1)C=CC=C3 [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C2=C1C([H])([H])C1=C2C([H])=C(Cl)C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=N1 [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3=C(C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])=C2OC1([H])[H] O=P(C(N1CCCCC1)C1=CC=CN=C1)(C1=CC=CC=C1)C1=CC=CC=C1 [H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N3C(=O)C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C(N=C(Cl)C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=N[C@@]([H])(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1 [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=NN=C1C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NN([H])C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC(=NC(=N1)C#N)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(OC([H])([H])C([H])([H])F)C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C(N1[H])C([H])=C(Cl)C([H])=C2[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(OC2=C([H])C([H])=C(C#N)C([H])=C2Cl)C1(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=N[C@@](C2=C(F)C([H])=C([H])C(=C2[H])C([H])([H])C(=O)C2=NC([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C([H])([H])S1 [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(N(C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)N(C(=O)C([H])([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]OC([H])([H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])N([H])C(=O)[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])F [H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=NN2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)C1=C([H])C(N([H])C2=NC(=NC3=C(C#N)C([H])=NN23)N([H])C2=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C2C(=O)N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C1[H] [H]O[P@@](=O)(C([H])([H])[H])[C@]([H])(C(=O)N([H])C(\[H])=C(/[H])C1=C([H])C(Cl)=C([H])C(F)=C1[H])C1=C([H])SC2=C1C([H])=C(Cl)C([H])=C2[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])S1)C1=NC(=C(O1)C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)OC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])C3=C(C4=C(N3[H])C([H])=C([H])C(F)=C4[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])C([H])([H])C([H])([H])N([H])[H])N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] FC(F)(F)C1=CC=C(SC[C@@H](C2CCNCC2)C2=CNC=N2)C=C1 [H]OC1=C2C([H])=C(C([H])=NC2=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])O1)C([H])([H])N([H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C2=C1C([H])=C([H])C1=C([H])N=C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C21)C([H])([H])N([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])N=C(N=C12)N([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@@](N([H])C(=O)OC([H])([H])[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]C1=NN2C(SC(=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])OC2(O[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C(=O)C([H])=C2[H] [H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C1=NC([H])=C([H])C([H])=N1)S(=O)(=O)N([H])C([H])([H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])SC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(Cl)[N+]([O-])=C(Cl)C([H])=C1C([H])([H])[H] COC1=CC=CC(CCN2CCN(CC2)C2=CC=CC=C2OC)=C1 COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)C(O)C3CCN(C)CC3)C2=O)C=C1 [H]OC([H])([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2F)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=NC2=C1C1=C([H])C(=C([H])C([H])=C1N2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=NN=C(O1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1[C@]([H])(N1C(=O)C([H])([H])N([H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)O[C@@]([H])(C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])[N@@+]12C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])[C@]([H])(N([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])[C@]2([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])[C@]([H])(N(C1=C2[H])C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])SC([H])([H])[H])C(F)(F)F [H]OC1=C([H])C([H])=C([H])C2=C1OC1=C(C2=O)C(O[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C3N=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]OC(=O)C1([H])C([H])([H])N(C2=C([H])C([H])=C(C(N([H])C(=O)C([H])([H])O[C@]3([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])[N+]([O-])=O)C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C(=O)C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22[C@]3([H])N([H])[C@@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]4(C([H])([H])[H])C([H])([H])[C@@]12C([H])=C([H])[C@]34OC([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])[C@]4(OC(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C1([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(S1)C1=NN(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C([H])C([H])=C(Cl)N=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])SC([H])([H])C([H])=C([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3S2)C1([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C#N)=C([H])C([H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N=C3N(N=S=C3S(=O)(=O)C([H])([H])[H])C2=C1[H] [H]N([H])C1=NC([H])=C(S1)C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C(=O)C2=C([H])C([H])=C(F)C3=C([H])C([H])=C([H])C([H])=C23)C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C([H])C2=C1OC([H])([H])C([H])([H])O2 [H]ON([H])C(=O)C1=C(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C(=O)C3=C([H])C4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])=C2[H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3Br)C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H] [H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@](C([H])([H])[H])(C1([H])[H])C([H])([H])[C@@](C([H])([H])[H])(C3([H])[H])C2([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]1=C(C(=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1N=NN=[N+]1C1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C2N=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] COC1=C(OCCC[N]2=CC=CC(C)=C2)C2=C[N]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3 [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=N1)C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C1=C([H])C(=NC([H])=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(F)=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(OC2=C(C(=NN2C([H])([H])[H])C(F)(F)F)C([H])([H])OC(=O)C([H])([H])[H])=C1[H])C(F)(F)F [H]N([H])C1=C(C(C2=C(OC([H])([H])[H])C([H])=C([H])C(F)=C2[H])=C2C(=O)N(C(=O)N(C2=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[H] [H]C1=C([H])N(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)SC3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H] [H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)C(=O)C3=C([H])C([H])=C([H])S3)C([H])([H])C([H])([H])[H])C3=C2C2=C([H])N(N=C2C([H])([H])C3([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC2=NC3=C([H])C([H])=C([H])C([H])=C3N2C1=O Cl.[H][C@@]12CCC3=CC=CC=C3[C@]1([H])CCN(CC1=CC=CO1)C2 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(S1)C([H])([H])C1=C(Cl)C([H])=C(C([H])=N1)C(F)(F)F [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H] [H]N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@](N([H])C(=O)O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N([H])[C@@]1([H])C([H])([H])N(C2=C(Br)C([H])=C([H])C([H])=C2\C([H])=C2/SC(=O)N([H])C2=O)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=NC([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])N1C(=O)N2C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1=O [H]N1C([H])=NC2=C1N=C(N1N=C(N=C21)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]