[H]N(C(=O)N1C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C2=C(C([H])=C1C([H])([H])[H])S(=O)(=O)N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])N2[H])C([H])([H])[H] [H]OC1([H])C([H])([H])C([H])([H])C2([H])C3([H])C([H])([H])C([H])=C4C([H])([H])C([H])(O[H])C([H])([H])C([H])([H])C4(\C([H])=C(/[H])OC([H])([H])[H])C3([H])C([H])([H])C([H])([H])C12C([H])([H])[H] [H]C1=NC2=C(C([H])=NC3=C2C([H])=C(C([H])=C3[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C(N=C([H])N1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C(F)(F)C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=NC2=C(N=C(C([H])=C2N1C([H])([H])[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F)C#N [H]N(C(=O)C([H])([H])[C@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] NCC(=O)N[C@@H](CC1=CC=C(I)C=C1)C(=O)C=[N]=N C[C@@H]1CCCC\C1=N\NC1=NC(=CS1)C1=CC=C(C=C1)N(O)=O [H]N([H])C1=C(N=C(C([H])=N1)C1=C([H])C(=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N([H])C1=NC2=C(S1)C([H])=C(N([H])C1=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N([H])C([H])([H])C4([H])[H])=C([H])C3=NC([H])=C1C#N)C([H])=C2[H] [H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NOC2=C([H])C([H])=C(C([H])=C12)N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=NC([H])=C1S(=O)(=O)N([H])[H])C(F)(F)F [H]N(C(=O)C1([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H] [H]C1=C(N(C(=C1C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])=C([H])C([H])=C2C1([H])[H] [H]N(C([H])([H])[C@]([H])(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]N1C2=NC3=C(N2C(=C1C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]([H])([C@@]2([H])ON3[C@@]([H])(C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C2([H])[H])[C@]2([H])[C@@]1([H])C(=O)O[C@@]2([H])C([H])([H])[H] [H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C2C(=O)OC([H])([H])C2=C([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C12 [H]N(C(=O)[C@]([H])(N1C(=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H])C([H])([H])C3([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])[C@]([H])(C([H])([H])OC([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])O1 CCCCN1CCC(COC(=O)C2=CC(OCCF)=C(N)C=C2)CC1 [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H] [H]N([H])C(=O)O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(OC2([H])[H])[C@@]([H])(C(=C(/[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H])[C@]1([H])OC([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C([H])=C4C([H])=C(C([H])=C([H])C4=N3)C(F)(F)F)C([H])([H])[C@@]12O[H] OCCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1 [H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N([H])C(=N/C(=O)C1=C([H])C([H])=C([H])C(F)=C1C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])\N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]\C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])=C(\[H])/C(/[H])=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C3=C([H])C([H])=C([H])N=C3C(=C2[H])C2=C([H])C([H])=C([H])C(OC([H])(F)F)=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(S1)N=C(N([H])C([H])([H])C([H])([H])[H])C1=C2N(C([H])=N1)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(OC2=C([H])C(F)=C([H])C(F)=C2[H])C(C#N)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C(=S)N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C([H])C(Cl)=C([H])C([H])=C3Cl)C([H])=C2[H])=C1\C(=N\C([H])([H])[C@@]([H])(O[H])C([H])([H])[H])N([H])[H] [H]OC(=O)C1=C(N=C(SC([H])([H])[H])N=C1SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])O[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)N([H])[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] NC1=C(C(=O)C2=CC(Cl)=C(Cl)C=C2)C2=C(CN(CCOC3=CC=C(C=C3)N(O)=O)CC2)S1 [H]\C(C(=O)N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])=C1/N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])P(=O)(O[H])O[H] [H]OC1=C(O[H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3=C1C2=C([H])C(SC([H])([H])[C@]([H])(N([H])[H])C(=O)OC([H])([H])[H])=C3[H] [H]O[C@@]1([H])C2=C(C(=NC([H])=N2)N2C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])N([H])[H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] C[C@H]1CC[C@H](C)N1CCCOC1=CC=C2N3CCNC(=O)C3=CC2=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=O)N=C(SC([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C([H])([H])OC1=NSN=C1C1=C(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])N=C12)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N(C(=O)N([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C([H])=C([H])S(=O)(=O)N([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)N(C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(C#CC1=C([H])C2=C3C([H])=C(Cl)C([H])=C([H])C3=C3N=C(N([H])C3=C2C([H])=C1[H])C1=C(C#N)C([H])=C([H])C([H])=C1C#N)(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C(=C1[H])C(\C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])[N+]([O-])=O [H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(N=C(N(C3=C([H])C([H])=C(C#N)C([H])=C3[H])C2=O)[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=NC([H])=C(Br)C([H])=C1[H] [H]C1=C([H])[C@]2(C([H])([H])[H])[C@]([H])(N(C1=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]N(C(=O)[C@]1([H])C(=O)N2C3=C(C([H])=C(F)C([H])=C13)C([H])([H])C1=C2C([H])=C([H])C(F)=C1[H])C1=NSC(=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] OB(O)[C@@H]1CCCN1C(=O)CN1C=CC=CC1=O [H]C1=C([H])C(F)=C(C([H])=C1[H])C(=O)C(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(OC(=O)N(C4=O)C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(O1)C1=NC(C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)=C2N=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([N+](=C([H])S1)C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C(Br)=C(S1)C1=C([H])C(N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C([H])([H])SC(C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(OC1=C([H])N(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C(C([H])=NN1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)OC([H])([H])[H])C(=S)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C(Cl)=C([H])C([H])=C3N2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C(=O)C2=C([H])N=C([H])C(Br)=C2[H])C([H])([H])C1([H])[H] [H]C([H])=C1OC(=N[C@]11C([H])([H])C([H])([H])[C@@]2([H])[C@@]3([H])C(=C4C(=C([H])C(=O)C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C(F)=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H] [H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@@]([H])(C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C(OC([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C#CC([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(C#N)=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(O[C@]3([H])C([H])=C(N([H])[H])C(C#N)=C(N([H])[H])[C@]3([H])C2([H])[H])=C1[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])OC1=C([H])C2=C(C([H])=C([H])N=C2[H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])C(=C([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C(=O)C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1OC([H])([H])[H])C1=C([H])C2=C(OC(=O)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C3C([H])=C([H])C([H])=C4C5=C(C([H])=C([H])C([H])=C5[H])C(C([H])=C2[H])=C34)=N1 [H]N([H])C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C(OC([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C(Cl)=C([H])N12)[C@@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])OC([H])([H])[C@]2(C([H])([H])O[H])C([H])([H])C([H])=C(C([H])([H])[H])[C@@]1([H])C2([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=N1 [H]N1C(=O)C2=C(C1=O)C1=C(C3=C2C2=C([H])C(=C([H])C([H])=C2N3[H])C2=NN([H])C(=O)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]\C(=C1\C(=O)C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=NN(C(=C1[H])C1=C([H])C([H])=C(I)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C(=O)C(\C#N)=C(/[H])C1=C([H])C(\C([H])=C(/C#N)C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@]2([H])SC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)C([H])=C1[H] [H]N([H])C1=NC2=C(OC3=C([H])C([H])=C([H])C(=C23)C(F)(F)F)C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(C(=O)N([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])=C1C1(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C2([H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H] [H]N(C(=S)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(=C1[H])[N+]([O-])=O [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C(F)=C([H])C([H])=C3N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C(=N1)C1=C([H])C([H])=C([H])O1 [H]OC(=O)C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N([H])C1=C(C([H])=C(C(Cl)=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C(Cl)C([H])=N2)C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(S2)[C@@]2([H])N(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]4([H])[C@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]4(C(=O)OC4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C([H])([H])[C@@]32C([H])([H])[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(OC3=C([H])C([H])=C([H])C(F)=C23)C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C3=C(C([H])=C12)N(C(=O)O3)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H] [H]N([H])C1=NC2=C(N=NN2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C(=N1)C1=C([H])C([H])=C([H])O1 [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C2=C(C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC(OC([H])([H])[H])=NC([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=O)C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])([H])C([H])([H])N1[H] CS(=O)(=O)C1=CC=C(C=C1)C(=O)N1CCOC2=CC=C(C=C2C1)C1=CC=C2N=CNC2=C1 [H]N(C1=C([H])C([H])=C(N=N1)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1 [H]C1=C(C2=NN(N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1F)C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C(OC2=C([H])C3=C(N([H])C([H])=C3[H])C([H])=C2[H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]C1=C([H])C([H])=C(OC(=O)C2=C([H])C3=C([H])C(=C([H])C([H])=C3OC2=O)C([H])([H])Cl)C(Cl)=C1[H] C[C@@H](OC[C@]1(CCCCN1)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C(C([H])=C1Cl)[N+]([O-])=O)C([H])([H])[H] [H]N1N=NN=C1C1=NN([H])C2=C1C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(Cl)=C(C([H])=C([H])C2=N1)C([H])([H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])N2C(=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C(N=C(N=C1[H])C([H])([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(\[H])=C(/[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=O)C2=C(O1)C([H])=C([H])C(C#N)=C2[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1(C([H])([H])N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]SC([H])([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S([O-])(=O)=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C#N)C2=C(C(SC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])=N1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=NC([H])=C(N=C1[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]N(C(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1N=C(C([H])=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])=NC(=N1)C1=C([H])C([H])=NC([H])=C1[H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])N=NS1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(N([H])C([H])([H])C2=C(C3=C(N=C(N=C3N=C2[H])N([H])[H])N([H])[H])C([H])([H])[H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C2C([H])=C([H])N(C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([C@@]([H])(OC([H])([H])[H])O[C@]1([H])OC([H])([H])[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])O[C@@]2(C3=C1C([H])=C(C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)[C@]1([H])C([H])([H])N(C([H])([H])[C@@]1([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)N1N=C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])C1([H])[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]1([H])N(C(=O)[C@@]1([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C(=C23)[C@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)[C@]1([H])C(=S)N([H])C(N([H])[H])=C(C#N)[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])C3([H])[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=[N+]([O-])C([H])=C([H])C(C(=O)C2=C(F)C([H])=C(F)C([H])=C2[H])=C1N([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] FC(F)(F)C1=C(Br)C=CC(NC(=O)CC2=NNC(=O)C3=CC=CC=C23)=C1 [H]N1C(=O)C([H])([H])C([H])([H])[C@@](C1=O)(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC(=O)C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)\C(=C(/[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C(N([H])C1=NC([H])=C([H])C(=N1)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C([H])([H])C1=NC([H])=C([H])S1)[C@]([H])(C([H])([H])[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]OC(=O)C([H])([H])OC1=C(C([H])=C(SC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] C[C@H](NC(=O)C1=CC2=C(S1)C(NC(=O)C1=CC=C(C=C1)N1CCOCC1)=NN2)C1=CC=CC=C1 [H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C(Cl)C(=NN1[H])C(=O)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H][C@]12C[C@]3([H])C[C@]([H])(C1)C[C@](C2)(C3)N(CC1=CC=C(C=C1)N(CC)CC)S(=O)(=O)C1=CC=C(OC)C=C1 [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C([H])([H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])OC2=C([H])C(F)=C([H])C([H])=C2C(=O)C1([H])[H] [H]OC(=O)C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])(F)F)=C1[H])C1([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=NC(=O)N=C12)C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[C@@]2([H])SC(=O)N([H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(SC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C1=NN([H])N=N1)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H] [H]C1=C([H])C(=C([H])C([H])=C1I)C(=O)C#CC1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC1=NC(OC2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])N([H])[H])=C(F)C([H])=C1F)[N+]([O-])=O [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NN(N=N1)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3O2)S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])N1C([H])=NN=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C2C([H])=C([H])C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)=C([H])C2=C([H])C([H])=C1[H] [H]ON(C(=O)N([H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])[C@]([H])(Cl)[C@@]2([H])OC([H])([H])C(=O)[C@@]12[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C(=N1)N(C(=O)C([H])=C2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])SC(=C1[H])S(=O)(=O)N([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC(=C(N12)C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[S@@](=O)C1=NC2=C(C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])N([H])[C@]([H])(C1([H])[H])C([H])([H])C(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C(Cl)=C1Cl)=C2C(=O)N(C([H])([H])C1=C(C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])N(O[C@]2([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]2([H])OC(=O)C([H])([H])[H])N=N1 [H]N([H])C(\SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=N/N=C(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC(SC([H])([H])[H])=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])C([H])=NC(=N1)N([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C(C(=O)C([H])([H])[H])C(OC(=O)C([H])([H])[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=O [H]N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]OC1=C(C([H])=C(\C([H])=C2/SC(=O)N(C2=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])[H])[N+]([O-])=O [H]N([H])C1=NC(C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)=C(C([H])=N1)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]C1=NC([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C3=C(C([H])=C2[H])N(C(=O)C3=C(C#N)C#N)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2[H])C([H])=C1[H] COC1=C(OC)C=C(NC(=O)NC2=CC=C(C=C2)C2=NC(=NC(=N2)N2CCOCC2)N2C3CCC2COC3)C=C1 [H]C#CC([H])([H])N1C(=O)N(C2=C(N(C(=N2)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2N(C(=O)C([H])([H])[H])C([H])([H])C2=C(OC([H])([H])C([H])([H])F)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C([H])C(Br)=C([H])C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2O1 [H]C1=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C21O[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(O1)C(=O)OC([H])([H])[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C(=C2C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C([H])([H])SC1=NC(=NS1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(=O)C([H])([H])N1N=NC(=N1)C1=C([H])N=C(N=C1[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C(Cl)=C(Cl)C(Cl)=C1[H] CCOC(=O)N1CCC(O)(CN2CC[C@@H](C2)N2C(=O)CC3=C2C=CC=C3)CC1 [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C(Cl)C([H])=C(Cl)C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] CNC(=O)C1=NC=C(C=C1)[C@]1(O)CCN([C@H]1C)C1=CC(OC)=C(C=C1)C#N [H]OC(=O)C1=NC([H])=C([H])C(=C1[H])C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=C(C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC([H])=NN1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@](C(=O)N([H])C1=C([H])C([H])=C2C(=O)ON=C(C2=C1[H])C([H])([H])[H])(C([H])([H])[C@]1([H])C2=C(C(Br)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(SC([H])([H])C([H])([H])C([H])([H])[H])=N1 [H]C1=NC2=C(C([H])=C1[H])N1C(=NC(=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])N2C1=C(Cl)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C(C([H])=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C1=C([H])C([H])=C([H])C([H])=C21 [H]O[C@@]1([H])[C@@]2([H])N([H])C([H])([H])[C@@]1(O[C@@]2([H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] FC(F)(F)C1=C(OC2=CC=C3NC(=NC3=C2)C2=CC(=CC=C2)C(=O)NCC2=CC=C(Cl)S2)C=CC=C1 [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(O[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2S1 [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C1=C2C([H])=C([H])C(F)=C([H])C2=NC(C2=NC([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=N\N=C(/[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OS(=O)(=O)C2=C(Cl)C([H])=C([H])C([H])=C2[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])[H] [H]N(C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C2C(OC([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C(F)C([H])=C4[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=NN(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C3N=C4C([H])=C(Br)C([H])=C([H])C4=C4C(=O)C([H])([H])[N+](C(C(=O)C2=C([H])N1C([H])([H])[H])=C34)(C([H])([H])[H])C([H])([H])[H] COCCC1(CCCC1)C(=O)N[C@@H](CC1=CC=C(C(C)=C1)C1=CN(C)C(=O)N(C)C1=O)C(O)=O [H]N1C([H])=NC(=C1[H])[C@]([H])(C1=C(Br)C(Br)=C([H])S1)C([H])([H])[H] [H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NN(C2=C1C(=C([H])N=C2[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=N2)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C3=C2C2=C(C4=C(C([H])=C([H])C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C4[H])N2C1([H])[H])C1=C3C([H])([H])N([H])C1=O [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])ON([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C#CC([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C3=C(N([H])C(=O)C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H] [H]C1=C([H])N(\C(S1)=N\C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NCC1CCN(CC1)C(=O)OCC1=CC=CC=C1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C(=C(/[H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C(C2=C([H])C([H])=NC([H])=N2)C(=N1)C1=C([H])C([H])=C([H])O1)C1=C([H])N=C([H])N=C1[H] [H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C([H])([H])OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])N2C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[P@@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)\C(=C(\[H])C2=C(C([H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=C([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC4=C(NN=C4N)C=C3)C2=O)C=C1 [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1Cl)[N+]([O-])=O)C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])[N+]([O-])=O [H]O[C@]([H])(C(=N\OC([H])([H])[H])\C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1(C3=C([H])C([H])=C(N([H])C(\S[H])=N/C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C4=C([H])C([H])=C(N([H])C(=O)C([H])([H])C5=C([H])C([H])=C(N([H])C6=C7N=C([H])N(C7=NC([H])=N6)[C@]6([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]6([H])O[H])C([H])=C5[H])C([H])=C4[H])C([H])=C3C(=O)C1([H])[H])C1=C(O2)C([H])=C(O[H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]12C([H])([H])C(=C([H])[H])[C@@]3([H])O[C@@]3(C(=O)OC([H])([H])[H])[C@]1(C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]1(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])=C([H])C(=O)OC([H])([H])[C@]3([C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]12[H] [H]C1=C([H])C(OC([H])(F)F)=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])[C@]12C([H])([H])C([H])([H])[C@](C3=NC(=NO3)C3=C([H])C([H])=C(F)C([H])=C3[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(C#N)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=NC(=NC([H])=C1[H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])OC([H])=C1[H] [H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(Br)C([H])=C2F)C(Cl)=C(OC([H])([H])[H])N=C1[H] [H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1F [H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)N1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=NC([H])=C([H])O1)C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC(=NC2=C1N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N([H])C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N=C(C3=C(C(=O)N(C3=O)C3=C(N(N=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C(=C1[H])S([O-])(=O)=O)C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C1=C(S2)C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C(SC(F)(F)F)=C([H])C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C2C3=C(C4=C(C([H])=C([H])C(F)=C4[H])N3C([H])([H])[H])C([H])([H])SC2=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C(C(=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H])S(=O)(=O)C([H])([H])[H] [H]C([H])=C(C#CC1=C([H])C([H])=C2N=C(C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])C(=O)N([H])C2=C1[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@@]([H])(OC([H])([H])C1=C(N=C(C#N)C([H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(=C(/[H])C([H])([H])C1=C(O[H])C2=C(C(=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC2=O)\C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C(N2[H])C2=C([H])C([H])=C([H])C(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)OC([H])([H])C1=C([H])[C@@]2([H])[C@@]3([H])OC([H])([H])O[C@@]3(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]2([H])C([H])=C(C(=O)[C@@]2(O[H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]SC([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C(=S)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)[C@@]([H])(N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C(S1)C1=NC2=C(C([H])=C([H])N=C2C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C(=C1C#N)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])O1 [H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] COCCOC1=C(C=CC=C1)C1=CC(C)=C(C=C1)C(CN)CC1=CC=C(OCCOC2=C(Cl)C=C(C)C=C2Cl)C=C1 [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])[C@@]([H])([N+]([H])([H])[H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(O[H])N=C2C([H])=C(C(=NC2=N1)[N+]([O-])=O)[N+]([O-])=O [H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@]13O[C@@]4(O[C@]([H])([C@]1([H])C([H])=C(C([H])([H])OC(=O)C([H])([H])C1=C(I)C([H])=C(OC(=O)C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C2([H])[H])[C@](O4)(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])N(OC([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C2C3=C(N1[H])C([H])=C([H])C([H])=C3C(=O)N([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]12[H])C([H])([H])[H] CC1=C(C)C(NC(=O)N2CCN(CC2)C2=NC(=CS2)C2=C(F)C=CC=C2)=NO1 [H]N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C1=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]\C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H] [H]C1=C2C(C(=O)[C@]([H])(C([H])([H])[H])C2([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C#N)C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C1=O [H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(C([H])([H])[H])C([H])([H])C(=O)[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)[C@]1([H])OC2=C(N=NC(SC([H])([H])C([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C(\[H])=C(\F)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(N=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(=N1)N([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(=C3[H])C2=NN([H])N=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])N=C3[H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(\N=C(/S[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C(=O)N([H])[C@]([H])(C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C(=O)O[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC([H])([H])[H] [H]OC1=C(O[H])/C(=N\C([H])(C([H])([H])[H])C([H])([H])[H])/C\1=N/C1=C([H])C([H])=C([H])C(C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1O[H] [H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C2/OC(=S)N(C2=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1Br [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=NC(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=C([H])C2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(SC3=C([H])C([H])=C([H])C([H])=C3O2)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C2C(SC(=C2C([H])([H])[H])C([H])([H])[H])=NC([H])=N1)[C@]1([H])C([H])([H])C([H])([H])S(=O)(=O)C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])SC2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N [H]C([H])([H])O[C@@]1([H])C(=O)N2C(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])([H])Cl)C([H])([H])S(=O)(=O)[C@]12[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] CCCCN1CCCC[C@H]1[C@H](CO)c1ccccc1 [H]C1=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C2OC(=O)C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(C2=C1[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C([H])C(C([H])=O)=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=N1)C(C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C(Cl)=C(F)C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C4=C([H])C([H])=C([H])C(C#N)=C4[H])C([H])([H])[C@]23[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=NC([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C([H])C(O[C@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=N1 [H]N(C1=NN=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(OC1=O)C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C(=O)N([H])C2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])[C@@]1([H])C([H])([H])N(C(=O)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C(=O)[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4[H])C([H])([H])[C@@]12[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC1=NC=CC=C1OC1=C(F)C(=NC=N1)N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 [H]OC(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C(N=C(N=C1N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C#N)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1OC([H])([H])C([H])([H])N1N=C([H])C([H])=C1[H])C([H])([H])N(C(=O)N([H])C([H])([H])C(F)(F)C([H])([H])[H])C2([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C(F)(F)C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])C([H])=C([H])C([H])([H])C1([H])[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2[N+](=C1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/C([H])([H])[H])[C@@]2([H])OC(=O)[C@@]3([H])N(C(=O)C(=O)[C@]4(O[H])O[C@@]([H])([C@@]([H])(OC([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])[H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])\C(=C([H])\[C@]([H])(C(=O)C([H])([H])[C@@]([H])(O[H])[C@@]2([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])[H] [H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NO[C@]2([H])C2=C([H])C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1 [H]N(C(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C2=C([H])C([H])=C(C([H])=C2Cl)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(F)=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C2=NC([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(C(=O)C2=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(OC(C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C2=C(O[C@@]([H])(C(=O)N([H])C3=C([H])C([H])=C(C([H])=C3[H])N3C([H])=C([H])N=C3C(=O)OC([H])([H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2S1 [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=C(C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1N([H])C(=NC1=S)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C([H])C(Cl)=N2 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(SC([H])=C2[H])C2=NN([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)OC([H])([H])[C@@]1([H])O[C@]([H])(O[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])OC(=O)C([H])([H])[H])C([H])([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C2=C(OC([H])=C2[H])C1=O [H]OC1=C(Cl)C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(N=C3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C2=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(N([H])C2=C([H])C3=C(N=C([H])N3[H])C([H])=C2[H])=C([H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=[N+]1C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=NC(=O)C2=C(SC3=C([H])C(=C([H])C([H])=C23)C([H])([H])[H])N1[H] [H]N(C(=O)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C([H])=C1C(=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC2=C([H])C(F)=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C([H])C4=NON=C4C([H])=C3[H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C(C#CC4=C([H])N=C(N4C([H])([H])[H])C(=O)N([H])C([H])([H])[H])=C3[H])C([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C(C(OC([H])([H])[H])=C1[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C1([H])[H])C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C([H])=C(\C([H])=C(/[H])C(=O)C5=C([H])C([H])=C([H])C([H])=C5[H])N4C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1)[C@]([H])(C(=O)N([H])S(=O)(=O)C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(I)C([H])=C2[H])C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@]1(C(=O)N([H])C2=C1C([H])=C(Br)C([H])=C2[H])C([H])([H])C(=O)C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2N(C([H])=NC2=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H] [H]ON([H])C(=O)C([H])([H])N1C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C2C1([H])[H] [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1F [H]OC(=O)C1=NN2C(=C1[H])C1=C([H])C(N3C([H])=C([H])C(C([H])=O)=C3[H])=C(Cl)C([H])=C1N=C2O[H] [H]N([H])C1=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=NC2=C([H])C(Cl)=C([H])C([H])=C12 [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C2N=C(OC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC1=C(F)C(F)=C(C([H])=C1[H])C(=O)N([H])\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C2C([H])=NN(C2=NC([H])=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H] [H]SC([H])([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(C(=O)C([H])([H])[H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C(S1)C([H])([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C2C(=NC(=C1C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C(\[H])=C(/[H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]N1C([H])=NC(=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])C#CC([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])OP([O-])([O-])=O)N1C([H])=C(F)C(=O)N([H])C1=O [H]OC([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1=O [H]OC1=C([H])C(F)=C(C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(O[H])C([H])=C([H])C2=C1[H] [H]N1C(=NC2=C1C(=C([H])C(=C2[H])C(F)(F)F)C1=NC([H])=C([H])N=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C(F)=C1C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])SC([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N([H])C(=O)C1=C(N(C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C(C(=O)OC(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])=[N+]([H])[H] [H]S\C(=N\C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])N(C2=NC(=C([H])C3=C([H])N=C([H])C([H])=C23)C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=NC([H])=C([H])N1C([H])([H])[C@@]([H])(C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N(C1=C([H])C2=C(N([H])C(=O)C([H])=C2C(F)(F)F)C([H])=C1[H])C([H])([H])C(F)(F)F [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=NC2=C(N=C(N=C2N=C1[H])N([H])[H])N([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(C#CC([H])([H])[H])C([H])=C2[H])C(=O)N([C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1=O [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C(C(=C1[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(F)C(N([H])C([H])([H])C(F)(F)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]C1=C([H])N=C(C([H])=N1)C1=NN=C(SC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])S1 [H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N(C(=O)N1N=C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C1C#N)C(=O)C([H])([H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1C([H])([H])N([H])C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C(=O)C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=O)N(C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C2C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])SC([H])([H])C2([H])[H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N1C([H])=C(C2=C1C([H])=NC([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(O[H])=C(N([H])S2(=O)=O)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N3C(=O)SC4=C([H])C([H])=C(Cl)C([H])=C34)C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C(=O)C2=C1C([H])=C([H])C(Cl)=C2[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(\N=N\N([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[C@@]1([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=C2C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H] [H]C1=NC2=C(C([H])=C([H])N=C2[H])N1C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C2=C(N=C(SC([H])([H])C(=O)N([H])C3=C([H])C(Cl)=C(C([H])=C3[H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])S2)C([H])=C1[H] [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(OC([H])(F)F)C([H])=C1Cl [H]N(C(=O)[C@]1([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C#N)C(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3OC(=C([H])C(=O)C3=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]S\C(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)=C(/C#N)C(=O)C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N([H])C1=C([H])C([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C1C([H])=NC(OC1=C(F)C([H])=C(F)C([H])=C1[H])=N2 [H]OC(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C2OC([H])=C([H])C(=O)C2=C(C([H])=C1[H])[N+]([O-])=O [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])OC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C(N3[H])C(F)=C(C([H])=C4[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]N([H])C1=NC([H])=NC2=C1C(=C([H])N2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC([H])=C1C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C#CC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C(Br)C([H])=C2OC1=O [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C(F)C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C2=C1C(=O)C([H])=C(O2)SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H] [H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])N=C([H])C(C#N)=C1[H] [H][C@@]12C[C@H](OC(=O)C3=CC=C(Cl)C=C3)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])C3=C(ON=C3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)=C1[H] [H]C1=NN2C(=N1)N=C([H])C(=C2C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]C([H])=C([H])C([H])([H])OC1=C([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C(=O)C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]O\C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1\C(=NC(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NC3=C([H])N=C([H])C([H])=C23)C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C(=O)O[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N([H])C(=NC2=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NN2C(=NC([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=NN=C2N1[C@@](C(=O)N2C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=O)\C(C([H])=C1[H])=C1\OC2=C([H])C([H])=C([H])C([H])=C2N1[H] [H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1O[H])C([H])([H])C([H])([H])N(C1=C(O[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C(C([H])=C(C(Cl)=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H]