[H]N1OC(=O)N=C1C1=C([H])C2=C(OC3=C([H])C([H])=C(I)C([H])=C3[H])C([H])=NC([H])=C2S1 [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C(=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(OC([H])([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])[H])=NC(=N1)C1=NC([H])=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CC(C)(C)C1=CC=C(NC(=O)N2CCC3=C(C2)NC2=C3C=C(O)C=C2)C=C1 [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NN=C(O1)[S@](=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C(N=C(N([H])C([H])([H])C2=NON=C2C([H])([H])[H])C1=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[N@+]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=N\OC([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C([N+]([O-])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(SC(=C2[H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2(C([H])([H])OC2([H])[H])C1([H])[H] [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1N([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C1=NN=C2N1C([H])([H])C([H])([H])C1=C2N(N=C1C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])N2C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(N=NC(=C2O1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(N([H])S(=O)(=O)C2=C([H])C3=C(S2)C2=C(N3[H])C([H])=C([H])C(F)=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC1=C([H])C(C#CC2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C(C(=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C([H])([H])[H] [H]OC1(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] COC1=CC2=C(C=C1)C1=C(\C2=N\OCCN(C)C)C2=CC=CC=C2N=C1 [H]OP(=O)(O[H])OC([H])([H])[C@]1([H])OC([H])([H])[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])[H])C([H])([H])[C@]1([H])OP(=O)(O[H])O[H] [H]N(C(=O)C1=NC(F)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=C([H])C3=C(N=C([H])N(C3=O)C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Br)C(=NO1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1P(=O)(O[H])O[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C1=C([H])C(C(=O)N([H])[H])=C(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=NC(=C([H])C(=N1)C([H])([H])S(=O)(=O)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C([H])N=C1SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C(=O)N([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=C(SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(OC(=C1N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)ON(C1=O)C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])C(OC2=C([H])C(Cl)=C([H])C(Cl)=C2[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(OC([H])([H])[H])C(O[H])=C2C(=O)C([H])=C(OC2=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])[H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C2=C(C([H])=C1Cl)C([H])([H])C([H])=C1N(C(=O)C([H])([H])C([H])([H])[C@@]21C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C1=NC([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C(N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=NC2=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=O [H]N1C2=C([H])C3=C(C([H])=C2[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C(=C([H])C(=O)N3C([H])([H])C([H])([H])[H])C(F)(F)F [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] CN1[C@@H]([C@@H](O[C@@H](CC2=CC=C(F)C=C2)C1=O)C1=CC=C(Br)C=C1)C1=CC=C(Br)C=C1 [H][C@]12C[C@@H](C(C)(C)C)[C@]34[C@@H](O)C(=O)O[C@H]3O[C@@]3(C(=O)O1)[C@@]1(O)[C@H](C)C(=O)O[C@H]1[C@H](OCOCC1=CC=CC=C1)C243 [H]C1=C([H])C([H])=C2C(F)=C([H])C([H])=C(OC3=NC4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C2=N1 [H]N([H])S(=O)(=O)C1=C([H])C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC(N([H])[H])=C2C3=C(C([H])=C([H])C2=N1)N(C([H])=C3[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)[C@@]1([H])SC([H])([H])C([H])([H])N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H] [H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])[C@]([H])(C2=C([H])OC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])N=C1C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C(Cl)C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C2N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])N(C2=C([H])C(=C1[H])C(F)(F)F)[C@@]([H])(C1=NN(N=N1)C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)[C@@]([H])(C([H])([H])C(=O)C1([H])C2=C(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@@]3([H])C([H])([H])N(C([H])([H])[C@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NO2)C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N2C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C(=O)N(C(=O)[C@]2(C1=O)C([H])([H])C1=C(N=C3C([H])=C([H])C([H])=C([H])N3C1=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]21[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])[C@@]3([H])N(O[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]OC1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C(=O)C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] COC1=CC=CC(=C1)C1=CC=C(S1)C(=O)N(C)C1=CC=CC(C)=C1 [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])SC2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C(O[H])=C1C(=O)C([H])([H])[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])N(C(=O)[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])[H])N2N=C([H])C(=C2[H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)[C@]([H])(O[H])[C@]1([H])O[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3OC(=C([H])C(=O)C3=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(C2=C([H])C3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=N[C@]([H])(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])O1 [H]N([H])C1=NC([H])=C(N=C1C([H])([H])N([H])C(=S)N([H])C1=C([H])C([H])=C(OC(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=NN=C([H])N2[H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1Cl [H]C1=C(OC(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])SC([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=NC([H])=NC2=C1N=C([H])N2[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C2N=C([H])N(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C4=C3C([H])=NN4[H])C2=NC([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])P(=O)(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C2N=C(SC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C#CC2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C([H])=C1[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])P(=O)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C(F)C(F)=C([H])C([H])=C1F)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC2(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(S\C(=C(\[H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)=N\C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(Cl)=C([H])N2C1=NC(=C2C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])N1C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@]12[H] [H]C1=C2N(C3=C(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1N=C(N=C2[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(N=C(N(C3=O)C([H])([H])C(=O)N([H])C([H])([H])C3([H])C([H])([H])C3([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(OC2=C(N([H])C(=O)C3=NC([H])=C([H])C(Cl)=C3[H])C(F)=C([H])C([H])=C2[H])C([H])=C1C(=O)O[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C(C([H])=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H] [H]\C(=C(\[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])C(=O)OC([H])([H])[C@]12[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=NC(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C3=C([H])C(F)=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C(SC2=N1)C([H])([H])C([H])([H])[H] [H]ON([H])C1=C2N=C([H])N(C2=NC([H])=C1[H])[C@@]1([H])O[C@]([H])(C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NOC(=N1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C(=O)[C@@]21[H] [H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C#CC1=C([H])N2N=C(N=C2C(=N1)N([H])[H])C1=C([H])C([H])=C([H])O1)C1(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])S3)=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(OC(=O)C2=C([H])C3=C(C([H])=C2[H])N2C(=C(C(=O)C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C(=NC([H])=N1)N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C([H])C([H])=C1C([H])([H])[H] [H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@]3([H])O[C@@]4([H])C(=C([H])[C@]3([H])[C@@]1([H])C2(C([H])([H])[H])C([H])([H])[H])C1=[N+](C2=C(C([H])=C(C([H])=C2[H])S([O-])(=O)=O)C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])F)[C@]3([H])C2([H])[H] [H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]N1N=C(C(=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C([H])([H])[H] [H]\C(=N/N1C([H])=NN=C1[H])C1=C([H])C([H])=C(S1)C([H])([H])[H] CCC1=NC2=C(N1[C@H]1CCC3=C1C=CC(=C3)C1=CC=CC=C1C1=NN=NN1)C(=O)N(CC1=C(OC(F)(F)F)C=CC=C1)C=C2 [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])N=C([H])C(C2=C([H])C3=C(N([H])N=C3C3=NC4=C([H])C(=C(C([H])=C4N3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C(OC(=O)C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C3=C(N=C([H])S3)C([H])=C2[H])C1=O [H]N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C1=NC([H])=C(N1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([C@@]1([H])C(=O)N(C2=NC([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1 [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C(Br)=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C(O[H])C([H])=C23)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C(F)=C(F)C(F)=C2[H])C([H])([H])C1([H])[H] Oc1cccc(Nc2nccc(n2)-c2sc(NCC[NH+]3CCCCC3)c(C#N)c2-c2cccc(Cl)c2)c1 [H]N(C(=O)C([H])([H])SC1=NN(C(=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(F)(F)F [H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(=O)NOC [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(N([H])C([H])([H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N([H])C1=C(Cl)C([H])=C([H])C2=C1OC([H])([H])O2)C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NOC(=N1)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C2/OC(=O)N(C2=O)C2=C([H])C([H])=C(N([H])C(=O)C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1Br [H]OC([H])([H])C([H])([H])N(C1=NC2=C(N=C([H])N2C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O[H] [H]OC(=O)C1=C([H])C2=C(N=C(C([H])=C2OC([H])([H])C2=C([H])C3=C(C([H])=C2[H])C(=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C3=O)C2=NN([H])N=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C(Cl)C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=N1 [H]N([H])C1=C2C(=NC([H])=N1)N=C(C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])=C2C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C(N([H])C1=NC(=C([H])C2=NC([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])N(C2=NC(=C([H])C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1Cl [H]N1C2=C(C([H])=C([H])C(Cl)=C2[H])[C@]2(C1=O)[C@]([H])(N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])N(N=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])O[C@@]([H])(O[C@]1([H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(N([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)N(C1=O)[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(=C1[H])[C@@]1([H])SC(=NN1C(=O)C1=C(F)C(OC([H])([H])[H])=C(F)C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C1=C(C(=O)N([H])C2=C(Cl)C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@]1([H])O[C@]2([H])C3=C([H])C(=C([H])C([H])=C3N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H])C(F)(F)F [H]N1C([H])=NC(=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(I)=C(/[H])C([H])([H])OC(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(ON=C1C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C1=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C(F)C(Cl)=C([H])C([H])=C3[H])C2=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(N3C([H])=C([H])C([H])=C3[H])N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])=NC(=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])N(C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@]2([H])SC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])C2=NN([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=C1C([H])=C([H])C([H])=C([H])N21)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC4([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]