[H]OC([H])([H])C([H])([H])C#CC1=NC(=C(N1C#C[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C2C(N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C(\Cl)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NN(N=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)S\C(=C(\[H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])=C2[H])C1=O
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@]([H])(C2=C([H])C3=C(C([H])=C2[H])C([H])=C(OC([H])([H])C2=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C2[H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@](N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)C2([H])C3=C(SC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])N=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C(=N\[C@@]2([H])C(=O)N(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])\N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C([H])C(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N([H])C(=S)N([H])\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])[N+]([O-])=O
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(N([H])[H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C2=C1C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@]2(OC(=O)C2=C([H])C([H])=C([H])O2)C(=O)C([H])([H])SC2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C2(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=NC(=NN2C(=N1)N([H])[H])C1=C([H])C([H])=C([H])O1
[H]OC1=C2C(OC(=C2C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C(Cl)C([H])=C1C([H])([H])C([H])([H])C([H])([H])O[H]
[H]C1=C([H])C2=C3OC4=C(C3=C(C(=O)OC([H])([H])[H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C4=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C(=O)[C@@]([H])(C1([H])[H])[C@]([H])(OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]OC(=O)C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C2([H])[H]
[H]OC(=O)C1=C(O[H])C(=NC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])OC1=NC([H])=NC(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C1=NC2=C(C([H])=C(N=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])N(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1Cl)C(=O)OC([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H]
[H]N1[C@@]2([H])C(C(=O)N(C([H])([H])C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C3([H])C([H])([H])C3([H])[H])=C(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])OC4=C(F)C([H])=C([H])C(Cl)=C4F)C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(=O)C1=C(C([H])=C(C([H])=C1[H])[N+]([O-])=O)[N+]([O-])=O
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C(=O)C3=C(C([H])=C([H])O3)C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N2N=NC([H])=C2[C@@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C(N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H]
CCN(C)C(=O)C1=CC=C2N=C(NC(=O)C3=CC=CC(=C3)C#N)N(CCCOC)C2=N1
[H]OC1=NC2=C([H])C(N([H])C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1[H]
[H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C(N([H])[H])C([H])=C([H])C3=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)O[H])C([H])([H])[H]
[H]OC1=NN=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C(=C1C(=O)C([H])([H])SC1=NN=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1O2)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(=O)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])N(C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C(=O)N(C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=C1[H])N(C([H])=C(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(O[H])[C@@]2([H])O[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C(/[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])=C([H])C2=C1N=C(N=C2[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C2N(N=C(C2=NC(=N1)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC2=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])=C2[H])[N+]([O-])=O
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C1=C(Cl)C([H])=C([H])C2=C1OC([H])([H])C([H])([H])O2
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]([H])(N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]OC(=O)C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C1=C(C(=C([H])C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1[H])N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C2O[C@]3(C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4(OC([H])([H])C([H])([H])[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=C2C([H])=C([H])N(C2=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Br)=C1[H])[C@]1([H])C2=C(OC(=O)C1([H])[H])C([H])=C([H])C1=C([H])C(=C([H])C([H])=C21)C([H])([H])[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])C4=C(C([H])=C3[H])N(C(=O)C([H])([H])O4)C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC([H])([H])C([H])([H])C3([H])[H])C2=C1[H]
[H]N(C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC([H])=NC(=C1[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C2N([H])N=C([H])C2=C1[H])C([H])([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])N(C(=O)C([H])=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(C#N)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])[C@]1([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=NC([H])=C2C([H])([H])C(=O)C2=C([H])C([H])=C(F)C(=N2)C2=C(F)C(F)=C([H])C([H])=C2F)C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2OC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C2=NN(N=N2)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C(SC([H])([H])C([H])([H])SC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[H])[C@@](O[H])(C(=O)OC([H])([H])C1=C([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]([H])(O[H])[C@]12[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=C([H])N(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])=C(C(=O)O2)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)C2=C(C1=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1\N=N\C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H]
[H]OP(=O)(O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C(Cl)=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C1[H]
[H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([C@@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])N2C([H])=C([H])N=C2C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=NN=C(S2)C2=C([H])C(C#N)=C(OC([H])([H])C(F)(F)F)C([H])=C2[H])C(=C1[H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C(F)=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H]
[H]N([H])C(=NC(=O)C1=C([H])C([H])=C(O1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(\C([H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(I)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C([H])C(N([H])C(=N/C([H])([H])C6=C([H])C([H])=C([H])C([H])=C6[H])\N([H])[H])=C([H])C([H])=C5N4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N(C2=NC(=NC([H])=C12)N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C([H])C(Cl)=C2[H]
[H]OC(=O)C([H])([H])[C@]([H])(SC1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C(N([H])C(=N[H])N([H])[H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1Cl)C(F)(F)F)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]1([H])C2=C(C([H])=C(Cl)C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O
[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C(O3)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])O\N=C1/C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=NN1[H])C1=NC(=NC(=C1[H])N1C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H])N([H])[H]
[H]OC([H])([H])C([H])([H])OC([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N(C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
Cc1cnc(NC2CC[NH2+]CC2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C(O[H])C(F)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2SC2=C1C([H])=C(C([H])=N2)C(F)(F)F
[H]N([H])C1=C([H])C(=NC(=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C(=O)C([H])([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C([H])C([H])=C2C(OC([H])=C(C3=C([H])N=C(C([H])=C3[H])N3C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C2=O)=C1[H]
[H]OC(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C#N)=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])N=C([H])C([H])=C1[H]
[H]OC1=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3\C2=N/OC([H])([H])C([H])([H])[N+]2([H])C([H])([H])C([H])([H])[N+]([H])([H])C([H])([H])C2([H])[H])C2=C(N1[H])C(Br)=C([H])C([H])=C2[H]
[H]C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C(F)C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C1=C([H])C2=C([H])N=C([H])C([H])=C2N1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C(=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1=O)C(F)(F)F
[H]N([C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C(C([H])=NC([H])=C2[H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C2N1[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])N1C(=O)C([H])([H])OC2=C1C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(N=[N+]=[N-])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]N1C([H])([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[C@]1([H])C([H])(F)F)C(F)(F)F
[H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N([H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=NC2=C(N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C2=C3C(OC([H])([H])[C@@]3([H])C([H])([H])C1([H])[H])=C(Br)C([H])=C2OC([H])([H])[H]
CCC1=C2NN=CC2=CC(CC(NC(=O)N2CCC(CC2)N2CC3=C(NC2=O)C=CC=C3)C(=O)N2CCC(CC2)N2CCCCC2)=C1
[H]N1N=C(N(C1=S)C([H])([H])C([H])([H])[H])C1=C([H])C2=C(S1)N(N=C2C(F)(F)F)C([H])([H])[H]
CCNc1ncc(CC)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C2N([H])C(=O)[C@]([H])(C3=NC([H])=C([H])N3[H])C2=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(F)=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)=N1
[H]N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC(=NS3)C(F)(F)F)C([H])([H])C2([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]C1=C(N=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@]([H])(OC1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=N\N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1Br
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=NC2=C1C(=NN2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C(Cl)=C3[H])N2C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(SC([H])([H])C([H])([H])C([H])([H])[H])=N1
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(\C(\[H])=C(/[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=O)N([H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC(Br)=C(N1)C1=CC=C(C=C1)N=[N+]=[N-]
[H]OC([H])([H])[C@]1(OC([H])([H])\C(=C(/[H])C([H])([H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C(N([H])C([H])([H])S([O-])(=O)=O)C([H])=C2[H])C([H])=C1[H]
[H]OC1=C2O[C@]3([H])\C(=N\N([H])C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@]4(O[H])[C@@]5([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C(N=C(C([H])=C2C(F)(F)F)C(F)(F)F)=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C([H])=NC([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C(=O)C(=C(C2=O)C2=C(C(=O)C3=C(C(O[H])=C(O[H])C([H])=C3C2=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=C1O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C(=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])S[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@]([H])(C(=O)C([H])([H])[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])N([H])[C@]([H])(C(=O)C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])C(=O)N3C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C1=O
[H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=C2[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])F
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)[C@]([H])(C([H])([H])[H])C1([H])[H])[N+]([O-])=O
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])=C([H])C(N(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])=C2Cl
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])SC1=NN=C(O1)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])[N+]([O-])=O
[H]OC1(C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])OC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(F)C(F)=C2[H]
[H]SC([H])([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=NC([H])=C1[H])N1C([H])=NC2=C1C([H])=NC([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C2=NN(C(=C2OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NN1C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N(C1=C(Cl)C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C(=C2O[C@@]([H])(C1=S)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])C(F)(F)F)=C([H])C(OC([H])([H])C(F)(F)F)=C2[H])C([H])=C1[H]
COC1=CC=CC(=C1)C1=NN=C(S1)C1=C(O)C=C(O)C=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1OC(C1=C([H])C([H])=C([H])C([H])=C1[H])=C(C2=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C2=NO[N+]([O-])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C(=O)N1OC(=O)C(=C1C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2OC([H])([H])C([H])([H])[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])=C=C([H])[H])C([H])=C2C(=NC([H])=NC2=C1[H])N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C(=NC(=N1)N1C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N(C3=C([H])C(F)=C(F)C([H])=C3[H])[C@@]2([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=C1OC([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
FC1=CC2=C(NC(=C2)C(=O)NCCN2CCC3(CC2)N(CNC3=O)C2=CC=C(Br)C=C2)C=C1
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CC1=C([H])N=C([H])C([H])=C1[H]
[H]C1=C(C#N)N(C(=C1[H])C1=C([H])C(F)=C2N(C(=O)C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23
[H]N=C(N([H])[H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2F)=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])C2=C3N(C(=O)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C3=C1[H])C([H])([H])[H]
[H]N1N(C(=O)C2=C1C([H])=C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H])C([H])([H])[C@@]1(N([H])C(=O)N([H])C1=O)C([H])([H])[H]
[H]N(N([H])C(=O)C1=C([H])C([H])=C(Br)O1)C(=S)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]\C(=N/N1C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@](N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])(F)F)C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(N2N=C3C(=C2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C3=O)C([H])([H])C(OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]OC1=C(\C(=N\C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2(C3=C([H])C([H])=C(Cl)C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])C([H])([H])N1C2=NC3=C(N2C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])N(C(=N1)C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=NC(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]OC1=C([H])C([H])=C2C([H])=C([H])C(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)=C([H])C2=C1[H]
[H]N1N=NC(=C1[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1\N=C1/SSN=C1Cl)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(O[H])C(F)(F)F)C(F)(F)F
[H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C(N=C2C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1(N([H])C(=O)C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])N1N=C(Cl)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N1C(=O)N(C2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])[C@@]2([H])C([H])([H])[H])C(F)(F)F
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C([H])([H])[H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]O[C@]1([H])C2=C(C([H])=C3C(N([H])C(C([H])=C3C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C2=C1C(F)=C([H])C(F)=C2[H]
[H]N([H])C1=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C([H])C(F)=C3[H])=C2C([H])=N1
CC1=CC(NC2=NC(NCC3=C(C)C=CC=N3)=NC=C2Br)=NN1
[H]N(C(=O)C([H])([H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])[H]
[H]N1[C@]([H])(N([H])[C@@]2([H])C(=O)N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])Br)[C@@]12[H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C(=O)C([H])([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]OC1=NC2=C(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H][C@@]12CCO[C@]1([H])C1=CC(CCCCC)=CC=C1N[C@@H]2C1CCCCC1
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])SC([H])=N1)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(=O)OC([H])([H])[H])C1=C2C(=C([H])C([H])=C1[H])C1=NN([H])C(C3=C([H])SC(C#CC([H])([H])OC4=C([H])C([H])=C([H])C([H])=C4[H])=C3[H])=C1C2([H])[H]
[H]OC(=O)C([H])([H])C(=O)N([H])C1=C2C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N1C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3C(=C21)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H]
[H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C(=NC2=C1C([H])=C([H])C([H])=N2)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C(=O)N2C([H])([H])[C@@]([H])(N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])C(=O)N2C3=C(OC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C13)C1=C([H])C([H])=C([H])C([H])=N1
CCN(CC)C1=CC=C(CN(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OC)C=C2)C=C1
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@]([H])(O[H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C4=NN=C(S4)S(=O)(=O)N([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(=C([H])C(=C2O1)C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=NC(=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
NC(=N)c1ccc2cc(NC(=O)Nc3ccccc3)ccc2c1
[H]N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])=C3C([H])=C([H])N(C3=N2)C2=C([H])C([H])=C([H])C([H])=N2)=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C(Cl)C(N(C2=NC(=C([H])C(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(\C([H])=C(/[H])C2=NC3=C([H])C(Cl)=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1
[H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(S\C(N([H])[H])=C(/C#N)\C(\C#N)=C(\SC2=C(O[H])C([H])=C([H])C([H])=C2[H])N([H])[H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@](C#C[C@@]1(OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(N([H])C(=O)[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])N=[N+]=[N-])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])[N+]([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(SC2([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N=C(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]([H])(O[H])C(\[H])=C(/[H])\C(\[H])=C(\[H])/C(/[H])=C(\[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C(Cl)C([H])=C2[H])N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]ON(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C2=C(O1)C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C2C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])[C@@](C1=O)(C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(Br)=C(OC([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C(Br)=C1[H]
[H]N(C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C2([H])[H])C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(OC1=O)C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1N=C(C(=O)N([H])C2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@]1(C(=O)OC([H])([H])[H])C([H])([H])[C@@]2([H])O[C@@]1(N1C3=C([H])C([H])=C(C([H])=C3C3=C1C1=C(C4=C(C([H])=C([H])C(=C4[H])C([H])([H])OC([H])([H])C([H])([H])[H])N21)C1=C3C([H])([H])N([H])C1=O)C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N=C([H])C2=C1N=C(N([H])[H])N1N=C(N=C21)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])O[H]
[H]N1N=C(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])N=C(C#N)C([H])=C1[H]
[H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(N=C1[H])C(F)(F)F)C1=C([H])N2C(=NC(=C2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC(=O)[C@](S1)(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C(C([H])([H])[H])(C([H])([H])[H])C1(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@]2([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN([H])C([H])=N1
[H]C([H])([H])N(C(=S)OC([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC2=C([H])C3=C([H])C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])O[H])=C([H])C([H])=C3N([H])C2=N1
[H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
CC(O\N=[N](\O)C1=CC=C(C=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F)OC(C)=O
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC(Cl)=C1C1=C([H])C(Cl)=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C(\[H])=C(/C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])N1C(=O)C2=C(OC([H])([H])C(F)(F)F)C3=C([H])C([H])=C([H])C([H])=C3C(OC([H])([H])C(F)(F)F)=C2C1([H])[H])C([H])([H])[H]
[H]\C(=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]SC1=C([H])C([H])=C([H])C(=N1)C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(N([H])C(=O)C2=NN=NN2C2=C(F)C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H]
[H]N([H])C1=C(C#N)C([H])(C(C#N)=C(S1)N([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C#N)C(F)(F)F
[H]C1=C([H])C(\N=C2/SC([H])([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])S(=O)(=O)C(F)(F)F
[H]N(C(=O)C1=C(N=C([H])N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])N=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C(=N[C@@]([H])(C1=O)C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N([H])C1=NN(C([H])=C1C1=C([H])C([H])=C2C(=O)N([H])C([H])([H])C2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=N/OC([H])([H])C#N)\C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(C2=NC3=C(N12)C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C(=O)OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)O[C@@]([H])(C([H])([H])OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(SC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N2C1=NC([H])=C2C([H])([H])[H]
OC(=O)C1=CC2=CC=CC=C2N1CCCOC1=CC=CC2=CC=CC=C12
[H]\C(=C(\[H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)OC([H])([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C#CC([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H]
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C(C2=NN(C3=C2N=C(N=C3N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1O[H])C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1(C2=NN=C(O2)C2=C(N(C(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])O[H])C([H])=C2C1=O)C([H])([H])C1=C(C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])[H])C(=O)O[H]
[H]C1=NC(=C2N1C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C21)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])N(N=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])O[C@@]([H])(N2C([H])=C(C3=C2C([H])=C([H])C([H])=C3Br)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]N(N1C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2C1([H])[H])C1=NC([H])([H])C([H])([H])N1[H]
[H]C1=C(C2=C(S1)N=C(OC2=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(N=O)=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H]
[H]N1N=C([H])C2=C1C([H])([H])C([H])([H])C1=C2N(N=C1C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C#N)C(=N\C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])\N1C([H])([H])C([H])([H])C(=C2C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1N2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1([H])[H]
[H]OC(=O)C1=NN([H])C2=C1C([H])([H])[C@]([H])(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]ON([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=NC(N([H])[C@]3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]3([H])F)=C([H])N=C2C([H])=C1[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])[C@@]([H])(N(C1=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1(OO[C@@]2(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
C[C@@H]1CCCCN1S(=O)(=O)C1=CC=C(C=C1)N1CCCC1=O
[H]N(C1=NC([H])=C2C(=C1[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C(F)(F)F)C([H])=C1[H]
[H]C1=C(Cl)C([H])=C(C#CC([H])([H])OC2=NSN=C2[C@]23C([H])([H])[N@@]4C([H])([H])[C@@]2([H])[C@@]3([H])C4([H])[H])C([H])=C1F
[H]C1=C(N=C2N1C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC2=C([H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2C(=O)N(C([H])([H])[H])C1(C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])O1
[H]N([H])C1=NC2=C(N=C(SC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C(=N1)N([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C3N=C(SC4(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])N([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=N[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(C(=C([H])S3)C(F)(F)F)C(=O)N2C([H])([H])C2=C(C#N)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C([H])O1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1[H]
[H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]OC([H])([H])[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)C([H])([H])C([H])([H])[C@]2([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
OC(=O)C1=NN=C(C=C1)N1CCC2(CC1)CCN(CC1=CC(=CC=C1)C(F)(F)F)C1=C(O2)C=CC=C1
[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])\N=C(/N([H])[H])[N+]([O-])=O
[H]C1=C([C@@]2([H])O[C@]1([H])[C@]1([H])[C@]3([H])O[C@@]([H])(C4=C3C3=C(C([H])=C([H])C([H])=C3[H])C(=O)C3=C4C([H])=C([H])C([H])=C3[H])[C@]21[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)SC3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N1C([H])=C(N2C(Cl)=C(Cl)C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C([H])C(C#N)=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C#CC([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C3=C2C2=C([H])C(=C([H])C([H])=C2N3[H])C(=O)C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3[H])S(=O)(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C(Cl)C(=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C2C(=NN1C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC1=NC(=C(C2=C([H])C([H])=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])[C@]([H])(N([H])C([H])([H])[C@]1([H])C(=C([H])[H])C([H])([H])[H])C(=O)O[H]
[H]N([H])C1=NC(N(C(=N1)N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C(C#N)=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])C3=O)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=NC2=C(N=C1O[H])C(=C([H])C(Br)=C2[H])C([H])([H])N([H])C(=O)C1=C(N=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(\N=C(\[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C(Cl)C(=O)N([H])N=C1[H]
[H]O[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)C(=O)C([H])([H])I
[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])P(=O)(O[H])O[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])N1N=C(C(Cl)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(\C(=N\S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=NC([H])=N1
[H]N(C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H])C([H])([H])C3([H])[H]
[H]ON([H])C(=O)N([H])C([H])([H])C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(F)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C2=NC([H])=C(Br)C([H])=C2N=C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])C([H])([H])C1=O
[H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C([H])S2)C2=C([H])C([H])=C(F)C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NOC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])N4C(=O)[C@@]5([H])N(C(=O)C4([H])[H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H]
[H]C1=C(N=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(N=N2)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=NC2=C([H])C([H])=C(OC([H])([H])[H])N=C2N2C(=NC(=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=N[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C(N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N(C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]O[C@@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C(\[H])=C(/[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
CC1=C(Cl)C=C2N=C(OC2=C1)N1CCC(CC1)C(=O)N[C@H]1CC[C@H](CC1)C(C)(C)O
[H]N([H])C1=NC2=C(Cl)C([H])=C([H])C([H])=C2C([H])([H])N1[H]
[H]N([H])C1=NC(N([H])C([H])([H])[C@]2([H])N(C([H])([H])C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])([H])C([H])([H])C2([H])[H])=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=NC2=C(S1)C([H])([H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@]([H])(OC(=O)[C@@]3([H])C([H])([H])[H])[C@@]1([H])[C@]2([H])C([H])([H])[H]
[H]N1C2=C([H])C(=NN2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C2=C([H])C(=NO2)C([H])([H])[H])=C1C([H])([H])[H])C(F)(F)F
[H]OC(=O)C1=NN([H])C(=C1F)C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(O[H])=C1OC1=C(C(F)=C([H])C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])O[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C1OC1=C3C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]3([H])C2([H])[H]
[H]N(C(=S)N(C([H])([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
OC(=O)CC1=CC(Br)=C(N(CC2=CC=C(OC3=CC=CC=C3F)C=C2)CC2=CC(F)=CC(F)=C2)C(Br)=C1
[H]OC([H])([H])C(=O)N([H])C1=C(OC2=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(C([H])=C(N1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=CC=CC=C1CNC1=NC(NC2CCCC2)=C(C=N1)C(=O)NCCC1=NN=NN1
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(\C([H])=N\N([H])C(=S)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C2C(=C1O[H])C1=C(O[H])C3=C(C(=O)C4=C(C([H])=C(O[H])C(=C4O[H])C([H])([H])[H])C3=O)C(OC([H])([H])[H])=C1C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3F)C([H])([H])[H])=C(C([H])=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(S1)S(=O)(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C2=C([H])C(=C(F)C(=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC1=C(OC([H])=C([H])C1=S)C(=S)N([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
C[C@@]1(O)CCCN(C1C(=O)NO)S(=O)(=O)C1=CC=C(OCC2=CC=NC3=CC=CC=C23)C=C1
[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C(N=C2C([H])=C([H])C(=C([H])N12)C1=C([H])N=C([H])N=C1C([H])([H])[H])N([H])C1=NN([H])C([H])=C1[H]
[H]OC1=NC(=NC(=C1N(C([H])([H])C1=C([H])N(C(=O)N([H])C1=O)[C@]1([H])O[C@]([H])(C([H])([H])OP([O-])([O-])=O)[C@]([H])(O[H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@@]([H])(C([O-])=O)C([H])([H])C([H])([H])C([O-])=O)C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C(Cl)C3=C(N=C(N=C3N([H])[H])N([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C2C([H])=C([H])C(C3=C([H])N(N=C3[H])C([H])([H])[H])=C(Cl)C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C(C(=O)C([H])([H])N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(\C(=N\C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)ON(C([H])([H])[H])C([H])([H])[H])N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C2N=C3C([H])=C([H])C(=C([H])C3=C2C([H])=C(N1C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])P(=O)(OC([H])([H])[H])OC([H])([H])[H]
CN(C1=CC=NC(NC2=CC=CC(=C2)S(C)(=O)=O)=N1)C1=C2OCOC2=CC=C1Cl
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=NC([H])=NC(=C2[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC([H])([H])C#CC1=C([H])N(C(=O)N([H])C1=O)[C@@]1([H])O[C@]([H])(C([H])([H])OP(=O)(O[H])O[H])[C@@]([H])(O[H])C1([H])[H]
[H]C1=C([H])C(=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(SC#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1([H])C2=C(OC3=C1C([H])=C(F)C([H])=C3[H])C([H])=C([H])C(F)=C2[H])C1=NC([H])=C([H])O1
[H]N1C(=C(C#N)[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
O=C1C=C(OC2=CC=C3C=CCOC3=C12)C1=CC=CC=C1
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NN([H])C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])=C1[H]
O=C(NC1CN2CCC1CC2)C1=CC=C(SC2=CC=CC=C2)C=C1
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SC([H])([H])\C([H])=C([H])\C([H])([H])SC1([H])[H])C([H])([H])[H]
[H]N=C(N([H])C1=NC(=C(S1)C([H])([H])[H])C1=C(N([H])C([H])=C1[H])C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C(N=N1)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=NC(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(F)=C3[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C2([H])[H]
[H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=NN([H])C([H])=C3[H])C([H])=C12
[H]OC1=C(Cl)C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1Cl
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])C([H])([H])[C@]2(C2=C([H])SC([H])=C2[H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])OC(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])OC(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])[N+]([O-])=C4C(F)(F)F)C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])N([H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
CC1(C)CCC2=C(N=C3SC4=C(N=CN=C4NCCN4CCOCC4)C3=C2C1)N1CCCC1
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(I)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N3C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H]
[H]N([H])C(=O)C1=C(N([H])C(=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(C([H])=C2C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C2=NC(=NC(N([H])C([H])([H])C([H])([H])[H])=C2[H])N([H])C2=C([H])C3=C(C([H])=C2[H])N(C([H])=C3[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])N=C(N=C1N([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N(C)CCCCCCN(C)C(=O)C1=CC=C(CNCCCCCCNCCSSCCNCCCCCCNCC2=CC=C(C=C2)C(=O)N(C)CCCCCCN(C)C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C=C1
[H]OC(=O)C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3F)C([H])([H])[H])=C(C([H])=N2)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C2/S\C(=N/C([H])(C([H])([H])[H])C([H])([H])[H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1OC([H])([H])[H])C1=NN=C2SC([H])([H])C(=NN12)C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C1=NC(=C([H])S1)C([H])([H])C1=NN=C(SC([H])([H])C(=O)N([H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23
[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C(=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=N1)C(F)(F)F)S(=O)(=O)C([H])([H])[H]
FC1=CC2=C(NC(=C2)C(=O)NCCN2CCC3(CC2)N(CNC3=O)C2=CC=CC(Cl)=C2)C=C1
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H]
[H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]1([H])N(C(=O)C([H])([H])C([H])([H])[H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]1([H])[C@@]([H])(C(=O)O[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(C(C#CC([H])([H])N([H])C(=O)C3=C([H])N=C([H])N(C3=O)C([H])([H])C3=C([H])C([H])=C(F)C(F)=C3[H])=C([H])C([H])=C2N=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C(=C([H])C(Br)=C2[H])C([H])([H])C(=O)C2=C([H])C([H])=C([H])O2)(C([H])([H])[H])C([H])([H])C([H])([H])S1
[H]C1=C([H])C(Cl)=C([H])C2=C1SC(=N2)C1=C([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N([C@]([H])(C(=O)OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C(F)=C(F)C(F)=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N([H])C(N([H])C([H])([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N([H])C(N([H])[H])=[N+]([H])[H])=[N+]([H])[H]
CC1=NN=C2CCC3=C(N12)C(Cl)=CC(=C3)C1=CN=CC=C1C(F)(F)F
[H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C(=C2C(=O)O1)C([H])([H])[H]
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(C(=C([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C(C(=O)C([H])([H])[C@]12C([H])([H])[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])C3([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(OC([H])([H])[H])C(=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])C([H])([H])N([H])[H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C#CC([H])([H])N([H])C([H])=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C2N([H])C(=O)N([H])C2=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C2N=C(SC2=C1[H])S(=O)(=O)N([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)[C@@]([H])(N(C(=O)C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H]
[H]C1=NC([H])=C2N=C(N(C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C2C3=C([H])C([H])=C(C([H])=C3C([H])([H])C2=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])SC(SC([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])[C@]2([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=N1
[H]N1C(=O)N([H])C(=O)C2(N(C3=C([H])N=C(OC4=C([H])C([H])=C(C([H])=C4[H])C4=NC(=C([H])O4)C4=C([H])C([H])=C([H])C(F)=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C1=O
[H]C1=NC(=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
NCCSCCC1=CNC2=CC=C(F)C=C12
[H]OC1=C([H])C([H])=C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])C([H])=C([H])C(N([H])[H])=C2[H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(Cl)=C1[H])N1N=C(C2=C([H])N=C(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C12)C([H])([H])[H]
CC(NS(=O)(=O)CC1=CC2=C(C=C1)C=CC1=C(C=C(C=N1)C1=CN(C)N=C1)C2=O)C1=CC=CC=C1
[H]C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C(=O)C([H])([H])[H])=C1[H]
[H]N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C(Cl)=C([H])C([H])=C2[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(O[C@@]2([H])C([H])([H])N(C3=NN=C(N3C3=C([H])C([H])=C(OC([H])([H])[H])N=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C(N=C(S1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C(=O)O[H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O
[H]N(C(=O)C1=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C(Br)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=NC(=NO4)C4=NC([H])=C([H])N=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]OC(=O)C1=C([H])C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1\C([H])=N\N([H])C(=S)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S([O-])(=O)=O
[H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])([H])[C@]1(N2N=NN=C2N(C1=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])C1=C3C(=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])[C@@]23[H]
[H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N(C(=O)OC1=C([H])C([H])=C2C(=C1[H])[C@@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])[C@@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=NN([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)N([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])N(C2=C1C([H])=C1C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC2(C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(\C([H])=C1/C(=O)C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]12C([H])([H])[N@]3C([H])([H])[N@@](C1([H])[H])C([H])([H])C([H])([H])[N@](C3([H])[H])C2([H])[H]
[H]N(\N=C(/[H])[C@]1([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1(Cl)Cl)C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H]
[H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(=C(OC2=C(C(OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2N(N=C(C2=NC(=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1[H]
[H]N(C1=N[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(I)C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]OC(=O)C([H])([H])N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
OB(O)C1=CC=C(C=C1)C(F)(F)F
[H]C1=C([H])C(F)=C(C(Cl)=C1[H])[C@]1([H])C([H])([H])N2C(=NC([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=NN(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2N([H])C([H])([H])C3=C(OC2=NC([H])=N1)C([H])=C([H])C(OC([H])([H])[H])=C3[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N2N=C([H])C(=C2[H])C2=C([H])C(=NO2)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C1[H]
[H]C1=NC2=C(C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(N=C([H])N2C([H])([H])[H])C(=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])C(C2=C(C3=C([H])C([H])=C([H])C([H])=C3S2)C1([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1(C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C(C#N)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC(=O)\C(S1)=C(\[H])C1=C([H])C([H])=C([H])O1
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C(F)=C([H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(OC3=C2C([H])=C(C([H])=C3[H])C2=NOC(=N2)C([H])([H])OC([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Cl)=C2[H]
[H]N(C(=O)C([H])([H])Cl)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C([H])=C([H])C(Br)=C3[H])C2=C1[H]
[H]OC1=C([H])C([H])=C2N=C(SC2=C1[H])C(=O)C1=C([H])C(O[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])SC([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3C([H])=C([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(O1)C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1F)C(=C(\F)C(=O)N([H])C1=C(Cl)C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])\C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C(=O)C2=C(N1[H])C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[C@@]([H])(N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]C1=C(OC2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(\C([H])=C3/SC(=S)N([H])C3=O)C([H])=C2[H])C(=C1O[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C2C(=O)C3=C(C(=O)C2=C(O[H])C2=C1C([H])([H])[C@@](O[H])(C(=O)C([H])([H])[H])C([H])([H])[C@]2([H])O[C@]1([H])O[C@@]([H])(C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(N([H])[H])C1([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3[H]
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)C([H])([H])[C@]2([H])N([H])C(=O)OC2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(N2N=C([H])C(OC([H])([H])C3=C([H])C([H])=C(F)C(F)=C3F)=C(Br)C2=O)C(Cl)=C1[H]
[H]OC(=O)[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C5=C(N([H])N=C5[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1I)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]C1=NN=C(O1)C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(S2)C(=O)C(F)(F)F)C([H])=C1[H]
[H]OC1=C(C([H])=NC2=NC(N([H])[H])=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C2N=C([H])N(C2=C([H])C(O[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C(F)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(C([O-])=O)=C1C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C(=C([H])C([H])=N2)C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)C([H])=C2C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC1=C2C([H])=C(C(=O)OC2=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C(O[H])C([H])=C([H])C([H])=C1[H]
[H]N(N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])N([H])C(=O)N([H])[H]
[H]N(\N=C(/[H])C1=C([H])N(N=C1C([H])([H])[H])C([H])([H])[H])C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(N=C2N1C([H])=C([H])C([H])=C2C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]12O[C@@](O[C@]([H])(C([H])([H])O[H])[C@@]1(O[H])C(=O)O[H])(C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])[C@@]2([H])O[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2C([H])=C([H])C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C34)=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])[C@]2([H])OC3=C4C([H])=C([H])C(=NC4=C([H])C([H])=C3OC2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C2N=C([H])N([H])C2=N1
[H]N(C(=O)C1=NSC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)[C@]([H])(N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
NC1=CC2=C(C3=CC=CC=C3)[N](CCCNCCCNCCCNC3=C4CCCCC4=NC4=CC=CC=C34)=C3C=C(N)C=CC3=C2C=C1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C(N([H])C3=C([H])C([H])=NC(=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1[H]
[H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C([H])=C(C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]C1=NC2=C(N=C1OC1=C([H])C([H])=C(Br)C([H])=C1F)C(=O)N(C(=N2)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1(C#CC2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])OC([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])C4=C3[C@@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]12C([H])([H])[H]
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C1N(C([H])=C2C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(C([H])=C2N([H])C([H])=C([H])C2=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]2([H])N(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N=C(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N1C2=NN(C([H])=C2C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])C(=O)C2=NC([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(N([H])C(=O)C([H])([H])OC5=C([H])C6=C(N([H])C([H])=C6C([H])([H])C([H])([H])N([H])[H])C([H])=C5[H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])=C12
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=N1
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C(Cl)C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H]
[H]C#CC([H])([H])OC1=NOC2=C1C([H])([H])[N+]([H])([H])C([H])([H])C2([H])[H]
[H]C1=C(C(=O)OC1([H])[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]2(OC2([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@](C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2N3C([H])=NC([H])=C3C(=NC2=C1[H])N([H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C1=C(C(=O)C([H])([H])[H])C(=NN(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N([H])C1=C(SC2=C1C(=C([H])C(=N2)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C(=O)C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C3([H])[H])C3=C2C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
C\C(=N/OCC1=CC(=C(C=C1)C1CCCCC1)C(F)(F)F)C1=CC=C(CNCCC(O)=O)C=C1
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C2=NC([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])N([H])C([H])([H])C([H])([H])OC3([H])[H])=C2[H])=C1[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C(=C2[H])C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(F)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C(F)=C([H])C(F)=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H]
[H]N(\N=C1\C2=C(N([H])C(=C2C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C(=C([H])N2[H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C(=N1)N([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C1/C(=O)C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]N1N=C(C(=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H])C(=O)OC([H])([H])[H]
[H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C(F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1(ON2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=NN2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C(=O)OC3=C2C([H])=C([H])C(Cl)=C3[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])\C([H])([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H]
[H]N(C(=O)C1=C([H])C(=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]S\C(=N\C1=C([H])C(Cl)=C([H])N=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2OC1=O)C1=NC2=C(S1)C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2N([H])[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C(N([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])S1)C1=C([H])N=C([H])C(=C1[H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=NOC([H])=N4)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]OC(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C(=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)S1)C(=O)N([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C(=C2C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O\N=C(\C(=O)N([H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C(Br)=C(O[H])C([H])=C1[H]
[H]N=C(N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C(O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C3=C([H])C([H])=C(OC4([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C4([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C2C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=NN3C([H])([H])[H])C([H])=C(Br)C2=NC([H])=C1C#N
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)O[C@@]1([H])C([H])([H])N([C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C3C(=C1[H])N(N=C3C([H])([H])N(C2=O)[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H][C@@]12C[C@H](OC(=O)C3=CC=C(SC)C=C3)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1
[H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C4(SC3([H])[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@@]([H])(C1=C([H])C([H])=C(O[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C(O[H])=C(C(=O)N([H])C4=C([H])C(=C([H])C([H])=C4OC([H])([H])[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@@]2([H])[C@@]3([H])C([H])([H])[N@@]4C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=NC3=C(S2)C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=S)N([H])C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C([H])([H])SC1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC2=C(N=C(N=C2N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSN=C2Cl)C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C12
[H]N(C1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(N1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H]
C\C(=N/OCC1=CC(=C(C=C1)C1=CC(F)=C(F)C=C1)C(F)(F)F)C1=CC=C(CNCCC(O)=O)C=C1
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])N2N=NC4=C2C([H])=C([H])C([H])=C4[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC([H])([H])[C@@]([H])(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C1=C([H])N([H])C2=C1N=C([H])N([H])C2=O
[H]N(C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
OC(COC1=CC=CC=C1)CN(CCCN1CCOCC1)C1CCN(CC1)C1=NC=NC2=C1C(=CS2)C1=CC=CC=C1
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])[C@@]([H])(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)OC([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(=NC(=N1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])=C1[H])C(=O)N([H])C1=C([H])N(N=C1C1=C(Cl)C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)O[H]
[H]N(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C(N(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])S(=O)(=O)N(C1=C([H])C(C#N)=C([H])C([H])=C1Cl)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C(Cl)C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N1)C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1F)C([H])([H])C(=O)OC([H])([H])C1=C([H])[C@@]2([H])[C@]3([H])O[C@]4(O[C@]3(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]2(O4)[C@]2([H])C([H])=C(C(=O)[C@@]2(O[H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])(F)F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C(SC([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])N1C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C(C(N(C2=NC(=NC(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C(C2=C([H])C(\N=N\N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C([H])([H])OC(=O)C([H])([H])[H])=C(Cl)C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@@]12[H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1(SC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]\C(C1=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1N=C(C([H])=C1C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1S(=O)(=O)C([H])([H])C([H])([H])C#N
[H]O[C@@]1([H])C([H])=C([H])[C@@]23C4=C(O[C@@]2([H])C1([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C4C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C3([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2F)=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=C(N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C(F)=C1[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)N(C(=O)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N1N=C2C3=C(OC4=C2C(=C([H])C([H])=C4[H])C1=O)C([H])=C([H])C(=C3[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N([H])C1=NC([H])=NC(OC2=C([H])C(Cl)=C(N([H])C(=O)N([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1\C([H])=N\OC([H])([H])[H]
[H]N(C(=O)C1=NC(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])=C([H])S1
[H]N(C1=C2C([H])=C(Cl)C([H])=C([H])C2=NN1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
COC1=CC=C2C=C(CNCC3=CC=C(C)C=C3)C(=NC2=C1)C1=CSC=C1
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=NN([H])N=N1
[H]N1C(=O)C2=C(N([H])C11C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]1([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N([C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])N=C2N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])[C@]2([H])C(=C([H])C([H])([H])[C@@]3([H])[C@]4(C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])[C@]([H])([C@@](O[H])(C(=O)C(\[H])=C(/[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C(=O)[C@@]23C([H])([H])[H])C(C1=O)(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@@]([H])(OC([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(I)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C(=NC2=C([H])C([H])=C([H])C([H])=C12)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(Cl)=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])N1N=C(C2=C1C(=O)N(C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H]
[H]N([H])C(=O)C1(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N(C1=C2C([H])=C([H])C(F)=C([H])C2=C2C(=O)N([H])C([H])=C([H])C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C(=C1C(=O)N1C2=C(C([H])=C3C([H])=C([H])N=C(N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C3=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C([H])=NS1)C1=C([H])N=C2C([H])=C(C([H])=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N([H])\N=C(/[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])N(C(=O)C(OC2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(C([H])=C34)C3=NC([H])=C([H])N3C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C3[H])[C@@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(Cl)C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C2=C3C(N([H])C(=O)\C3=C(\[H])C3=C(OC([H])([H])[H])C([H])=C([H])N3[H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H]
CNC(=O)CC1=COC2=CC(OS(=O)(=O)C3=CC=CC(Cl)=C3)=CC=C12
[H]N(C1=C(Cl)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(=O)[C@]([H])(C#N)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]O[C@@](C(=O)N([H])C1=C([H])C(=C(C#N)C([H])=C1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(OC([H])([H])[H])=C(N([H])C3=NN4C(=C([H])C([H])=C4C4=NC([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])=N3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])C2=C1C([H])=C(C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])ON(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])=C1[H]
[H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=NC([H])=NC(N([H])C3=NN([H])C(=C3[H])C([H])([H])C(=O)N([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2C([H])=C1OC([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])N=C(N([H])C([H])([H])C([H])([H])N2N=C([H])C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
OC(CNC1CCN(CC1)C1=NC=NC2=C1C(=CS2)C1=CC=CC=C1)COC1=CC=CC=C1F
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C([H])N=C(C([H])=C2C1=O)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(=O)C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(O2)C2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C(=O)C([H])=C2C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N(C(=O)C1=C2C(=O)C3=C(C([H])=C(C([H])=C3[H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])S(=O)(=O)C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(N1C([H])([H])[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C([H])N=C3[H])C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]3([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C3([H])[H])C(=O)N([H])[H])N([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C2=C3C([H])=C([H])C(Cl)=C([H])C3=NC([H])=C2[H])C([H])=C1C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1F
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(SC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=O)C3=C(C([H])=C([H])C4=C3SN(C4=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C(=O)C2=C1[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])C1=NOC(=N1)C1([H])C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]O\C(=N/C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C1=C([H])C([H])=C([H])C([H])=C21)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=NC(=NN1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(=N\OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C(=O)N([H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C(Br)=C(F)C([H])=C2[H])C([H])=N1
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])=C1[H])C(C(=O)OC([H])([H])[H])=C(O2)N([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(OC2=C([H])C(C(=O)N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(O[H])C([H])=C2[H])C(Cl)=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)O[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]N(C1=C2C([H])=C(F)N=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)C1=C2N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]3([H])C([H])([H])C([H])=C([H])[C@@]3([H])C2=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])C([H])=C=C([H])[H])C([H])=C2C(=NC([H])=NC2=C1[H])N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1N=C2N(C1=O)C1=C(N=C([H])C([H])=C1[H])N=C2N([H])[H]
[H]C1=NC([H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(Cl)=C3C(=O)N(C([H])=C([H])C3=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C2C([H])=C([H])C([H])=C3C4=C([H])C([H])=C([H])C([H])=C4C(=O)C(N=C1[H])=C23)C([H])([H])C([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N1C(=O)N([H])C(=O)C(OC2=C([H])N=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=C2C(=NC3=C(C(=NN13)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(C([H])=C1[H])N1N=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C(C2=C([H])C(=C(N([H])C([H])([H])C([H])([H])N([H])[H])C([H])=C2[H])[N+]([O-])=O)C(=N1)C([H])([H])C([H])([H])[H]
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(Cl)=C(SC([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=N2)[C@@]2(C1=O)C([H])([H])C1=NC([H])=C(\C([H])=C(/[H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(C(F)=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C2([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])=NO1
[H]N1C(=O)[C@@]2([H])C([H])([H])SC([H])([H])C([H])([H])[C@]2([H])N=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(N([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H])=C(C([H])=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])N=C(Cl)C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2F)=C1[H]
[H]N1N=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@@]2([H])C1=NC([H])=C([H])N1[H]
[H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)N1C(=O)[C@]2([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C1=C(S2)C([H])=C([H])C(F)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(OC([H])([H])[H])=NC(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C1=C([H])C([H])=C(O[H])C([H])=C1F
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(SC([H])([H])[H])N=C2N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C2\C3=NC4=C([H])C(Cl)=C([H])C([H])=C4C(=O)N3C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=NOC(=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C2=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3OC2=O)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C(=O)N1[H])C1=C([H])C([H])=C([H])N=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C(=O)OC([H])([H])[H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)N2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(N([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])N4N=C([H])C([H])=N4)C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(Br)=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])[C@@]12C([H])([H])C([H])([H])[C@@](C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C(O[H])=C(Br)C([H])=C1\C([H])=C(/[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])[C@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C2([H])[H]
FC(F)(F)C1=CC(=CC(COC[C@]2(CCCN(CC3=CC=CC=C3)CC2)C2=CC=CC=C2)=C1)C(F)(F)F
[H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=NC([H])=NC(N([H])C3=NN([H])C(=C3[H])C([H])([H])C(=O)N([H])C3=C(F)C(F)=C([H])C([H])=C3[H])=C2C([H])=C1OC([H])([H])[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(OC2=C(C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C(=O)C2=C(C1=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C(Br)=C([H])C2=C1OC(=C([H])C2=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])=C1[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C(N([H])C3=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]OC([H])([H])C1(C(=O)N(C2=C(\C([H])=C(/[H])C(=O)N([H])S(=O)(=O)C3=C([H])C(F)=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])O[H]
[H]N(C(=O)C1=C([H])C2=C(OC([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])[N@@]2C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])C1([H])[H]
[H]ON(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])C([H])=C1[H]
[H]OC1=NC2=C(N1[H])C([H])=C(Cl)C([H])=C2OC([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2N=C1[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(N=C23)C#CC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C#N)N([H])OC([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1([H])[H])C1=C3C([H])([H])C([H])([H])C2=NN(C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N(C(=N1)N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C([H])=C(OC(=O)C2=C([H])C3=C([H])C(=C([H])C([H])=C3OC2=O)C([H])([H])Cl)C(Cl)=C1[H]
CCOC(=O)C1=C(CCC(F)(F)F)N2N=C(C=C(C2=C1C(=O)OCC)C1=CC=CC=C1)N1CCOCC1
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(\C(=C(\F)C(=O)N([H])C2=C(F)C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)N([H])[H])C([H])([H])[H])=C(N([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=NC2=C(C([H])=N1)C([H])=C(Cl)C([H])=C2[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N=C2C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N(C(=O)N1N=C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])C1([H])[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC(=O)N1C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])[N+]([O-])=O
CN1N=C(CC(=O)NC2=CC(C)=C(Cl)C=C2)C2=CC=CC=C2C1=O
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N([H])C(=O)S2)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
C[C@@]1(N=C(N)OCC1(F)F)C1=CC(NC(=O)C2=NC=C(OC(F)(F)F)C=C2)=CC=C1F
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])N2C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])S2(=O)=O)(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C(=NC4=C3C([H])=C([H])N=C4[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2N1C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C2=C(N([H])C3=C2C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(O[H])[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3[H])C3=NC4=C(S3)C([H])([H])C([H])([H])C([H])([H])O4)C([H])=C2C([H])([H])C1([H])[H]
[H]C1=NN(C(=C1C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])N=N1
[H]N(\C(=N/S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C2=C(OC(=C2C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)\N=C1\SC(=NN1C([H])([H])[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)\N=C1\SC(=NN1C([H])([H])[H])S(=O)(=O)N([H])[H]
[H]N(C(=O)[C@]1([H])OS(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C(=O)N2C([H])([H])[H])C2=NC([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C2=O
[H]OC(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)O[H]
[H]N1N=C(N(\N=C(/[H])C2=C(C([H])=C([H])S2)C([H])([H])[H])C1=S)C1=NN([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Br)=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=C(C(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NN=C(O1)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N=C([H])S2)C([H])([H])C1([H])[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C2[H])C1([H])[H]
[H]OC(=O)C(=N\O[C@]([H])(C1=C([H])C2=C([H])C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])C([H])=C2S1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C([H])=C2C(=C1[H])N1C(=C([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=NC(=O)N([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C(=N1)N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C1=NC([H])([H])C([H])([H])N1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)O2)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H]
[H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])Cl)C(=O)C([H])([H])Cl
[H]OC(=O)[C@@]([H])(C#N)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C([H])([H])C([H])([H])Cl
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(F)(F)F
[H]OC1=C(C2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(Cl)C([H])=C1F)C1=C([H])C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])[H])C([H])=C1[H]
[H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=NN(C(=C1[H])C(=O)N1C2=C(C([H])=C([H])C(=C2[H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2ON=C(N([H])[H])C2=C1[H]
[H]N1C(=NC2=C1C([H])=C(F)C(F)=C2[H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]O\N=C(/N([H])[H])C1=C([H])C2=C(N([H])C3=NC([H])=C([H])C([H])=N3)C([H])=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H]
[H]C#CC([H])([H])N([H])C1=NC([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C2SC([H])=C([H])C2=C1[H]
[H]N1C(=O)N([H])C(=O)C(C1=O)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C1=C2C(=NC([H])=N1)N([H])C(=O)\C2=C(\[H])C1=C([H])C([H])=C(N1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(=O)N([H])[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C(S1)C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]2([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2C(=S)S\C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C2=O)C([H])=C1[H]
[H]N1C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C(Cl)S2)C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O
[H]N(C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C2=C(C([H])=C1Cl)C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])N([H])C(=O)C1=C([H])N(C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])SC(=N1)C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N=C(N([H])C1=C(Cl)C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(F)(F)F)C([H])([H])N(C1=O)C([H])([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3[H])C3=NC(OC([H])([H])C([H])([H])[H])=C(S3)C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C2[H])C(=C([H])C(=N3)C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C(Cl)C(=C([H])C(Cl)=C1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])C3=C(C(=C(O3)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C2=C([H])C([H])=C(C(N([H])C3=NC([H])=C(S3)C3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1)N([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C(=O)C([H])([H])C([H])([H])[C@@]1(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(C2=C([H])C3=C(N2[H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C1O[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC([H])=C(S1)N(C([H])([H])C([H])=C([H])[H])C([H])([H])C1=C([H])C2=C(N=C(N([H])C2=O)C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O1
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C1/C2=C([H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])=[N+](N2C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C2N=C(N(C2=C1[H])C1=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(/C1=C([H])N=C([H])N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])N(C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C2=C(N(C(=O)C([H])=C2[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C2N=C([H])N(\C([H])=C(\[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=NC(=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])P(=O)(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(\N=N\C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])C([H])=C([H])N=C2[H])=C1[H]
[H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C(C([H])=C([H])C([H])=C4[H])C(=O)N([H])C4=C([H])C([H])=C5N=C(C([H])=C(N([H])[H])C5=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])=C12)C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC(=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(N(C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])[H]
[H]ON(C([H])=O)[C@@]([H])(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C([H])([H])[C@@]1([H])N2C(=O)C(=O)N([H])C3=C([H])C(Cl)=C([H])C(=C23)C([H])([H])C1([H])[H])C([H])([H])N([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C2=NC(=C([H])C(=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=NC(OC([H])([H])C([H])([H])OC(=O)C2=C([H])OC([H])=C2[H])=C1OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]OC(C1=C([H])C([H])=C([H])N=C1[H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])N=C(N=C1SC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C2O[C@]3([H])OC([H])([H])[C@@](C2=C1[H])(C([H])([H])[H])C3([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C(F)C(F)=C12)C([H])([H])N(C1=C([H])N=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(S1)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)C([H])([H])C([H])([H])C([H])([H])C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N2[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(N=C(N=C12)C#N)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C([H])C([H])=C1[H]
[H]O[C@]1(OC([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N1C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C(C1=O)=C23)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(C([H])=C([H])N=C3N2C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(C(C#N)=C1C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])OC([H])=C3[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C(=O)C([H])([H])SC1=NC2=C(N1[H])C([H])=C(C([H])=C2[H])[N+]([O-])=O
[H]OC1=C([H])C2=C(C(=O)C(=C(C2=O)C2=C(C(=O)C3=C(C(=O)C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C(O[H])=C(O[H])C([H])=C3C2=O)C([H])([H])[H])C([H])([H])[H])C(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1O[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)[C@]2([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@]2([H])C1=O)C(=O)OC([H])([H])C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C2=C([H])C3=C(N2[H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C1O[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1=O)[C@]1([H])C([H])=C([H])S(=O)(=O)C1([H])[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C1=NC2=C(SC3=C([H])C(Cl)=C([H])C([H])=C23)C(=N1)N1C([H])([H])[C@@]2([H])N([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1Cl
[H]OC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C(N=C2C([H])=C([H])C(OC([H])([H])[H])=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(C(=O)N([H])[N+]3=C(C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(C2=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N([H])C1=C([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(Cl)C([H])=C2N2C([H])=NN=C12
[H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2(C(=O)N(C(=O)C2([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])([H])[H]
OC1=C(O)C=C(\C=C\C(=O)NC2=CC=CC=C2Cl)C=C1
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]1(O[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
O=C(NC1=CC=C(C=C1)C1=CSC2=C1OC(=CC2=O)N1CCOCC1)C1=CN=CC=C1
[H]OC(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C(C(=O)N([H])C2(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)C2=C([H])C([H])=C([H])N=C12
[H]C1=C(N=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C(=N[H])N([H])[H]
[H]N1C([H])=C(N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=S)N([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])O1)C(Cl)(Cl)Cl)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC1=C(C([H])=C2O[C@]([H])(C([H])([H])C([H])([H])SC3=NC([H])=C([H])C([H])=C3[H])C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN(C3=C2N=C(C([H])=C3N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl
[H]N([H])C1=C2C([H])=C([H])C(Cl)=C([H])C2=[N+]([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])[C@]([H])(C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC1=NC2=C(N=C1O[H])C(=C([H])C(Br)=C2[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])N([H])C([H])([H])C(F)(F)F)C1=NC([H])=C([H])O1
[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(/[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])N([O-])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=NC([H])=C(Cl)C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C([H])SC2=NC(=N1)C([H])([H])[H]
[H]OC(=O)C1=C(C2=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C#N)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C(=O)OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C1=NN(C2=C1C([H])=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C(=N2)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C2=O)C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])[H])N(N=C2SC([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1F
[H]ON([H])C(=O)C([H])([H])N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
[H]N(C1=NN2C(=NN=C2C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C4N(C(=O)C([H])([H])C5=C(OC([H])([H])[H])C([H])=C([H])C([H])=C5OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C(=O)O[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([C@@]1([H])C(=O)N(C2=NC([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1
[H]N(C1=C(C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[N+]([O-])=O)[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])SC([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])[H]
[H]C1=C2N3C(=NC([H])([H])C4(C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C(=O)C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C2C([H])=C([H])C(=C([H])C2=NC(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])=C(C([H])=C(O[H])C2=O)C(=O)OC([H])([H])[H]
[H]C1=C(N(N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1SC(F)(F)F)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
CC(=O)N1N=C(CC1C1=CC=C2OCOC2=C1)C1=CC=C(C)C=C1
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])[C@@](C2=C([H])C(O[H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(N([H])C(=O)[C@@]2([H])N(C(=O)N([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(C([H])=C(F)C([H])=C3N2C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]2(C([H])([H])C2([H])[H])[C@@]([H])(O[H])[C@]1([H])O[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C2C([H])=C(N(C(=O)C3=C([H])C([H])=C(OC([H])([H])[C@@]4([H])OC5=C(OC4([H])[H])C([H])=C([H])C([H])=C5[H])C([H])=C3[H])C2=C([H])C([H])=C1[H])C([H])([H])[H]
CC(=O)N1N=C(CC1C1=CC=C(O)C=C1)C1=CC2=C(Br)C=CC=C2OC1=O
[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)[C@]2([H])OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(N(C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C(Br)O1)[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2OC3=C([H])C([H])=C([H])C([H])=C3C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C2[H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])N(C4=C(C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C(=O)C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])N([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=NN1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]12C([H])([H])C3=C(O[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]14OC(=O)[C@](OC([H])([H])[H])(C(=O)[C@]21C([H])([H])[H])C4(C([H])([H])[H])C([H])([H])[H])C([H])=C(OC3=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(F)=C([H])C2=C1N(C([H])=C2C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N(C(=O)[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C2C(OC3=C([H])C([H])=C([H])C([H])=C23)=C1[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2[C@@]([H])(SC([H])([H])[C@]2([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])[H]
[H]C1=NC(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)O1
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C1=NN=C(O1)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C2(OC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])C([H])=C2C(=C1[H])\C(=N\OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C1=C(Cl)C(=NC2=C(C(=NN12)N([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(C([H])=C([H])N2C1=NC(=C2C([H])([H])C#N)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N=C(F)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])N=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@](C([H])([H])N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)OC2([H])[H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C2C3=C1C(=O)C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C2([H])[H])C([H])([H])[H]
CCCCN(C(=O)C1=CC=CC(F)=C1)C1=NN=C(S1)C1=CC=CN=C1
[H]N(C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(=C1S2(=O)=O)C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C(SC([H])([H])[H])S1)C1=NC(=C([H])S1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SN=N1)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
ClC1=C(NCN2N=C(OC2=S)C2=NC3=CC=CC=C3C=C2)C=CC=C1
CCOC(=O)C1=CN(CC2=CC=C(OC)C(OC)=C2)C=C(C1C1=CC=C(Cl)C=C1)C(=O)OCC
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(=C(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(N1C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C#CC([H])([H])N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C(=C(/[H])C1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])SC([H])=C2[H])=C1[H])[N+]([O-])=O)\C1=C(F)C([H])=C([H])C([H])=C1Cl
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)C1=C([H])C2=C(S1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C2([H])[H]
[H]N(OC([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C(S1)N(C(=O)N(C2=O)C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C(C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C1C1=NC(N([H])[H])=C(C#N)C(=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=C(F)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=O)[C@](O1)(C1=C([H])C([H])=C(Cl)S1)C([H])([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])SC(=N1)N([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])=C2[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[C@]2([H])OC([H])([H])C([H])([H])N(C2([H])[H])C2([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(\N=C(\C1=C([H])C([H])=C(Cl)S1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C([H])S1)C1=NC2=C([H])C([H])=C(Cl)C([H])=C2S1
[H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12
[H]OC(=O)C([H])([H])C([H])([H])N([H])C1=C(C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=NN=C(SC([H])([H])C(=O)OC([H])([H])[H])N1N([H])C(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])N(N=C2C2=C([H])C([H])=C([H])S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N1C(=O)S\C(=C(\[H])/C(/[H])=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])N([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12)C([H])([H])[H]
[H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=O)[C@@](S1)(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C([H])=C([H])C([H])([H])N([H])C1=NC(=C([H])S1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C(=O)OC([H])([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=NC(=C1[H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[C@]4([H])C([H])([H])C5=C(N([H])C6=C5C([H])=C(F)C([H])=C6[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])([H])C1=O
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(F)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])SC2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
OC1=CC(O)=C(C=C1)C1=NN=C(S1)C1=C(F)C=CC=C1
[H]\C(=C1/SC(=S)N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C(=O)N([H])[C@]([H])([N+](=N[H])N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]N([H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C2=C(S1)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C#N)C1=NN=C(S1)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=C([H])C(=C1Cl)C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C(N([H])[H])=C(O[C@@]2([H])C([H])([H])[C@@]([H])(OC3=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(N([H])C(=N[H])N([H])[H])C([H])([H])[C@]2([H])N([H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])([H])C(=O)N([H])C1=C([H])C([H])=NC([H])=C21)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2(N([H])C(=O)C3=C([H])C4=C(C([H])=C3[H])C(=C(N4C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=N3)C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C(C([H])=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])S1
[H]OC(=O)[C@@]1(F)[C@]2([H])C([H])([H])[C@@]([H])(OC([H])([H])C3=C([H])C(F)=C([H])C(F)=C3[H])[C@@](N([H])[H])(C(=O)O[H])[C@]12[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])S2(=O)=O
[H]N([H])C(=O)C1=C([H])C([H])=C(N([H])C(=S)N2N=C(C(=C2[H])C2=C([H])N3N=C([H])N=C3C([H])=C2[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]1(O[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]OP(=O)(O[H])C([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])P(=O)(O[H])O[H]
[H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C12
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NC2=C(C([H])=C1[H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])N(C(=O)C(Cl)=C1F)C([H])([H])[H])[C@]([H])(C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H]
[H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(C([H])=N1)C([H])([H])[H]
[H]N1C([H])([H])C2=C(N(C3=C([H])C(=C([H])C([H])=C23)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C2=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C(Br)SC(=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(F)C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CC(CC1=NN=C(CC2=C(Cl)C=CC(=C2)C2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)S1)C1=CC=CC=C1
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=NC3=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]4([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C3C(=O)[C@]2([H])C([H])=C1[H]
[H]N1C(=NC2=C1C([H])=C(Cl)C(Cl)=C2[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(OC(C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]OC1=C(C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=NC(=C([H])N2C([H])([H])[H])C(F)(F)F)C([H])=C1[H])C(=O)N([H])[H]
[H]OS(=O)(=O)C1=C([H])C2=C(N([H])C(=O)\C2=C2/N([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(N=C([H])C([H])=N2)C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])N(C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])SC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C3=C(Cl)N(N=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
CN1C=C(C2=NC3=C(O2)C=C(CC(=O)N2C[C@@H](F)C[C@H]2CO[C@H]2CC[C@@H](CC2)C(O)=O)C=C3)C2=C1C=CC=C2
[H]O[C@@]1(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)N([H])C([H])([H])C3=C([H])C([H])=NC([H])=N3)C([H])=C2[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C(=C2OC(=C([H])C(=O)C2=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=O)[C@]2(C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([H])C(=O)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H]
[H]OC(=O)C1=C(Cl)C([H])=C(F)C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O)[C@@]1([H])C([H])([H])OC2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(SC2=C(Cl)N=C(N=C2N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl
[H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=C([H])C3=C2SC(=C3[H])C2=NC([H])=C([H])C([H])=N2)C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(SC([H])([H])[H])=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C(Br)=C23)C1([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C(=O)C(\C#N)=C(/[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C(=NC4=C3C([H])=C([H])N=C4[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C1=C([H])N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(O1)N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])S[H]
[H]N(C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(N=C2N=C1C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])SC1=NC([H])=NC2=C1N=C([H])N2[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H])[N+]([O-])=O
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])C([H])([H])C3([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H]
[H]N(C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
CC1=C(Cl)C=CC=C1CN1C2=C(SC(=N2)N2CCOCC2)C(=O)N=C1CO
NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)NC1=CC=NC(=N1)C(F)(F)F)C(C3)C2
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C2=C(C([H])=C([H])C(F)=C2[H])C1=O
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(N(C(=O)N(C2=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N
[H]O[C@]1(C(=O)N([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C(N=C23)C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C2=NC([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C1C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C2=C(C([H])=NC(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C(Cl)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])[C@]([H])(C1([H])[H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C2([H])[C@@](C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]2(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])[C@@]3([H])C(=C([H])[H])C(=O)[C@@]12C3([H])[H]
[H]OC(=O)C1=C(N=C(N1[H])C([H])([H])N(C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC(N([H])C3=NC([H])=C(S3)C#N)=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC([H])=C([H])N12)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H]
[H]OC1=NSC(N([H])C2=C(Cl)C([H])=C(I)C([H])=C2[H])=C1\C(=N\C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]O[C@]([H])(C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC([H])([H])[H]
[H]O[C@@]([H])(C1=C([H])C2=C(S1)C([H])([H])[C@]([H])(OC([H])([H])[H])O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(SC3=C([H])C4=C(OC([H])([H])C([H])([H])O4)C([H])=C3[H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])N(N=N1)C([H])([H])C([H])([H])N([H])C1=C2SC([H])=C([H])C2=NC([H])=N1
[H]N(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN(C([H])=N1)C1=NC2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1
[H]N1C(=O)N([H])C(=O)C2(N(C(=O)C([H])([H])C([H])([H])C2([H])[H])C2=C([H])N=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1=O
[H]N([H])C1=NC(N([H])[H])=C2N=C(C([H])=NC2=N1)C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)N(N=O)C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2\C(=O)\C(=C(/[H])C3=C([H])C(OC([H])([H])[H])=C(O[H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1C(=O)\C(=C(\[H])C2=C(C([H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C(Cl)=C([H])C([H])=C12
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C(F)(F)F)C(F)(F)F
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])[C@]1([H])O[H]
[H]OC(=O)C1=C([H])C([H])=C(O1)C1=C([H])C2=C(N=C([H])N=C2N([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])=C1[H]
[H]N([H])C1=C(C#N)C(C2=C([H])SC([H])=C2[H])=C(C#N)C(SC([H])([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=N1
[H]C1([H])OC(=O)O[C@]11C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=C2N(C(=NC2=C([H])C(=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C(=C(SC3=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])N2[H])C([H])([H])C([H])([H])[H])C(=N1)N([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H]
OC1=C(Cl)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])C([H])=C([H])S1
[H]OC1=NC2=C([H])C([H])=C(Cl)C([H])=C2N2N=C(N=C12)C1=C([H])C([H])=C([H])O1
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C2=C(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C13)C([H])([H])C([H])([H])N=C2[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C1=NN=C(S1)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]1(C#CC([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]3([H])C(=C4C(=C([H])C(=O)C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])[C@@]([H])(C3=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C3OC([H])([H])[H])C([H])([H])[C@]12C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])N=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Br)C([H])=N1
[H]N(C(=O)C1=C(N(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(S1)C1=NC(=NO1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C1C1=C([H])C([H])=C(F)C(F)=C1C([H])([H])S2)C(F)(F)F
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C3C(=O)N(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C(=O)C3=C3C4=C(C([H])=C(O[H])C([H])=C4[H])N(C3=C1N2[H])[C@@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])N=C2N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1F
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C3=C([H])C(OC([H])([H])C4=NOC(=N4)C4=C(F)C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1C#N)N1C(=O)O[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C2N=C(N([H])C2=C1[H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])OC(=C1[H])S(=O)(=O)N([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[C@@]([H])(C#N)N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[N+]([H])([H])[H]
[H]N([H])C1=C(C([H])=C(N([H])C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1C2=O)S([O-])(=O)=O
[H]OC1=C2O[C@]3(C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4(OC([H])([H])C([H])([H])[H])[C@]5([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@@]3([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
NC1(CCC1)C1=CC=C(C=C1)C1=NN=C2N1C1=CC(=CN=C1NC1=C2C=CC=C1)C1=CC=CC=C1
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C(O[H])C(=O)C2=C([H])C(=C([H])C(N3C(=O)C([H])([H])C([H])([H])C3([H])[H])=C2O1)C([H])([H])[H]
[H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Cl)=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C(O[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])=C2[H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])N=C1[H])C1=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=NC([H])=N1)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C(F)(F)F)C1=C(N=C([H])C([H])=C1[H])N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@](C#N)(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[P@](=O)(C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[C@@]1([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])[C@]([H])(N([H])[H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C(F)(C2=NC([H])=C(N2C([H])([H])[H])C2=C([H])C(=NO2)C2=C(F)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])C(=O)N3C([H])([H])SC([H])([H])C3([H])[H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=NC2=C([H])C([H])=C(Cl)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C(=O)O[H])=C2C([H])=C(Cl)C([H])=C([H])C2=N1
[H]N(C(=O)C([H])([H])N1C(=O)N([H])C2=C1C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])C2=C([H])C([H])=C(Cl)C([H])=C2N([H])C(=O)[C@@]1([H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C(O[H])=C1O[H])C(=O)O[C@]1([H])O[C@]2([H])C([H])([H])OC(=O)C3=C([H])C(O[H])=C(O[H])C(O[H])=C3C3=C(C([H])=C(O[H])C(O[H])=C3O[H])C(=O)O[C@@]2([H])[C@]([H])(OC(=O)C2=C([H])C(O[H])=C(O[H])C(O[H])=C2[H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(O[H])C(O[H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)S\C(=C(\[H])C2=C([H])N=C([H])C([H])=C2[H])C1=O
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(Br)C([H])=C2C(=NN([H])C2=C1[H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=O)C(O[H])=C(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[N+]([H])([H])C([H])([H])[C@@]2(O[H])OC([H])([H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]2([H])O[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(I)=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H]
[H]N([H])C(=O)[C@@]1(N([H])C(=O)OC1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C(N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])=C([H])C(OC([H])([H])C(=O)OC([H])([H])[H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(O[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])C([H])=C3[H])N1C([H])([H])[H])C1=C2C(=O)N([H])C1=O
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1N([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C2[H])C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C(S1)C1=C(C#N)C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C1=NN=C(S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N([H])\C(=N/C(=O)C4=C([H])C([H])=NC([H])=C4[H])N(C3=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C2=C(Cl)C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C(SC([H])=N1)C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H]
[H]C([H])([H])O[C@@]([H])(C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OP([O-])(=O)OC([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(O1)C(=O)[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(N([H])C(=O)C(F)(F)C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[C@]4([H])OC(OC4([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C3=O)C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N([H])[H])C([H])([H])N([H])C1=NC(=C([H])C2=C1C([H])=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C4OC([H])([H])C([H])([H])OC4=C3[H])C([H])=C12)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])N2C2=C(C([H])=C([H])N=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=NC2=C1C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H]
[H]N([H])C1=C([H])C(=NN1C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N([C@]1([H])C(=O)N(C2=C([H])C3=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(Cl)=C([H])N([H])C2=C1[H]
[H]N([H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H]
[H]N(C(=O)C1=C([H])C([H])=C(S1)C(=O)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(/C1=C([H])C(=C([H])C(=C1OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NN=NN1C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C2N([H])C(=O)N(C2=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=C(N=C1C1([H])OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C(=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[H])C1=C(O[H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(N1[H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)N([H])C2=C(Cl)C([H])=C([H])C3=C2OC([H])([H])O3)=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C1N([H])C([H])([H])C([H])([H])C(=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(N([H])C(=O)C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@](N([H])C(=O)O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[P@](=O)(O[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])[H]
[H]OC1=C([H])C2=C(OC3=NC([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C(=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=NC(=C(N1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C(=O)N(C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC([H])=C(Cl)C(=N2)C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C(N=C(N=C1[H])C([H])([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(SC(=S)N1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N1N=C(N(\N=C(/[H])\C(=C(/[H])C2=C([H])C([H])=C([H])O2)\C([H])([H])[H])C1=S)C1=NN([H])C(=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C(N([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C(=O)C([H])=C(N([H])C(=O)\C(=C(/[H])\C(\[H])=C([H])/[C@]([H])(OC([H])([H])[H])[C@@]([H])(OC(=O)N([H])[H])\C(=C([H])\[C@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=O
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])C(=O)N(C([H])([H])C1=NN=NN1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1C([H])([H])[H]
[H]N1C(=O)C(=O)C2=C1C([H])=C([H])C(OC(F)(F)F)=C2[H]
[H]C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])F
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H]
[H]N1C(=O)C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=NC(=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(C2=NC(=C3N2C2=C([H])C(=C([H])C(OC([H])([H])[H])=C2N=C3C([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C(C([H])=N1)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C(O[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]2([H])N(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1N=C(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C3=C(N=C2[H])C([H])=C([H])C([H])=C3[H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
[H]S\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N1N=C(C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C2=C(\[H])C([H])([H])N2C([H])=NC3=C2C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C([H])C([H])=C([H])O2)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C(F)C(F)=C([H])C([H])=C2[H])=NC2=NC(=C([H])N=C12)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=N1)N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(F)(=O)=O)C([H])([H])C([H])([H])C([H])([H])N1C2=C(N=C(N2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C(F)C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@](C([H])([H])N([H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])N(C(=O)C1=C(C([H])=C([H])C([H])=C1F)S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C([H])C2=C1N=C(N=C2[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C(=O)C([H])=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=N1)C([H])([H])[H]
[H]N1C([H])=NC2=C1C1=NC(=NN1C(=N2)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(C([H])([H])N(C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O)C([H])([H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C(OC([H])([H])C([H])([H])[H])=N1)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])C1=C(C2=C([H])N(N=C2[H])C([H])([H])[H])C(=NC2=C(C([H])=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])C(F)(F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@](N1N=NC2=C1C([H])=C([H])C([H])=C2[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(F)=C([H])C([H])=C1C1=C([H])C(=C(C#N)C(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])SC1=C2C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C#N)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C1=NC(=C([H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CNC1=NC(C)=C(S1)C1=C(O)C=NC(NC2=CC=CC(=C2)[N+]([O-])=O)=N1
[H]N(C1=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C(=C([H])S1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]4([H])N(C(=O)[C@@]5([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])SSC3([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])O[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])C4([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C1=C(C(=O)OC([H])([H])[H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])[H])=C1[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C(OC1=C2C(=NC([H])=NC2=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C(Cl)=C1[H])(C([H])([H])[H])C([H])([H])[H]
N[C@@H](CC(O)=O)C1=NC(=CN1)C1=CC=C(OCC2=CC=C(C=C2)C2=CC=CC=C2)C(=C1)C(F)(F)F
[H]C1=C([H])C(=C([H])C2=C1C([H])([H])[C@@]([H])(N(C(=O)C1=NC([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C2([H])[H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(N=C3C([H])=C([H])C([H])=C([H])C3=C2C(=O)N([H])[C@@]([H])(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)[C@@]1([H])N(N=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])N(C(=C1[H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=NC(=C([H])S1)C(=N/OC([H])([H])[H])\C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C(C([H])([H])[H])C([H])([H])N([H])C1=NC([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])\N=C(/N([H])[H])[N+]([H])([H])[H])C1([H])[H]
[H]N1C(=N[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OP(=O)(O[H])C1=C([H])C(=C([H])C2=C1N=C(C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@](N1N=NC2=C1C([H])=C([H])C([H])=C2[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)P(=O)(O[H])O[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C(=O)O[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H]
COC1=CC=C(NC(=O)\C=C\C2=CC(O)=CC=C2)C=C1
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]N(C1=NN(C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@]([H])(O[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=N1)[C@@]([H])(N(C([H])([H])[H])C([H])([H])C1=NC3=C(C([H])=C([H])C([H])=C3[H])N1C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C1=NC(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])N23)=C(F)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@@]([H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N(C1=NC(=NC2=C1N=NN2C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N1N=C(C2=C(C1=O)C([H])([H])C([H])([H])C([H])([H])N2[H])C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C(=O)N([H])C([H])([H])C1([H])[H]
[H]O\C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])C([H])([H])SC([H])([H])[H])[C@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C(=N1)[C@@]1([H])O[C@]([H])(Br)C([H])([H])C1([H])[H])C([H])([H])C1=C2C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[P@](=O)(O[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])[C@@]([H])(C([H])([H])[H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]SC1=NN=C(O1)C1=C(N([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C(=O)N(C([H])([H])OC(=O)C3=C(Cl)C([H])=C([H])C([H])=C3Cl)S2(=O)=O)C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N1C(=O)C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(F)C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])N=C([H])C([H])=C1[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]([H])(O[C@@]1([H])N1C([H])=C([H])C(=NC1=O)N([H])[H])C([H])([H])O[P@@](=O)(O[H])OP(=O)(O[H])O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])[C@]([H])(O[H])[C@@]([H])(O[H])C1([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4C(F)(F)F)C([H])([H])C3([H])[H])C([H])=C12
[H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2OC([H])([H])[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N=C1[H])N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC(=O)C([H])([H])N1C2=C(C([H])=C(Cl)C([H])=C2[H])[C@]2(C1=O)C([H])([H])N(C(=O)C2([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C(Cl)=C1[H]
CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)C2=C(F)C=C(OC)C=C2)CCCCC1
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C(=C1C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C#N)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N2C(=C1[H])C(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NN=NN1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]1([H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C(N=C(N([H])[H])N1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C(C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F
[H]C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N(C(=O)C2=C1C([H])=C([H])C(I)=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2C#N)C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
CCC[C@@H]1O[C@@H](OC2=C(OC3=CC(O)=CC(O)=C3C2=O)C2=CC=C(O)C=C2)[C@H](O)[C@H](OC(C)=O)[C@H]1OC(C)=O
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=N2)N2C(=O)N(C3=NC([H])=C([H])N=C3[H])C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(N([H])C([H])([H])C(F)(F)F)(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C(C(C#N)=C1[H])C(F)(F)F)N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@]1(O[C@]2(C([H])([H])[H])C([H])([H])N(C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NOC2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(C1=NN=C2N1C([H])=C(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C(=C1[H])[N+]([O-])=O)S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])N(C3=C([H])C([H])=C([H])N=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])ON1C(=O)C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)OC([H])([H])[H])[C@]12[H]
[H]C1=C([H])C(=C([H])C([H])=C1O[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)OC([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N1C(=O)N(C2=C([H])N=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C2(C(=O)N([H])C(=O)N([H])C2=O)C1([H])[H]
[H]C1=NC(=NC([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2O1
[H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]C#CC([H])([H])N(C(=O)[C@@]1(C2=C([H])C([H])=C([H])S2)C([H])([H])[C@@]1([H])C([H])([H])N([H])[H])C([H])([H])C#C[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C([H])C([H])=C12
[H]N(C(=O)C(\[H])=C(/[H])C(=O)C1=C([H])C([H])=C([H])C(C#N)=C1[H])[C@]([H])(C1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)O1)C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@@]2([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[C@]([H])(C3=C([H])OC([H])=C3[H])C([H])([H])[C@]21C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C(=O)OC([H])([H])[H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])[N+]([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(SC2([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])N([H])C4=C3C([H])=C(OC([H])([H])[H])C([H])=C4[H])C2=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C2N([H])C(=O)C(C3=NC([H])=C([H])S3)=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C2N=C(N(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NN2[H])C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C4=C(C([H])=C([H])C([H])=C4[H])C3=O)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=NN(C2=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])SC([H])([H])C([H])([H])[C@@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])([H])[C@@]2(C(=O)C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2C(OC([H])=C(C2=O)C2=C([H])N=C(C([H])=C2[H])N2C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])=C1[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=NC4=C(N3[H])C(=O)N(N=C4C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]ON(C([H])=O)[C@]([H])(C([H])=C1C([H])([H])C([H])([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C(=NS1)C([H])([H])[H])C1=NC([H])=C([H])N2C1=NC([H])=C2C1=C([H])N(N=C1[H])C([H])([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C(Cl)=C([H])N=C23)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])SC2=C1C([H])=NC([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
COCCCN1C(NC(=O)C2=CC(OC)=CC=C2)=NC2=CC(=CC=C12)C(=O)NCC1=CC(OC)=CC=C1
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@@]1([H])[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@]12[H]
[H]OC1=C(Cl)C([H])=C(\C([H])=C2/S\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CCOC(=O)C1=NN2C(=C1C(=O)OCC)C1=C(NC2=O)C=CC=C1
[H]N(\N=C(/[H])\C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C3=C(C4=C([H])C([H])=C([H])C([H])=C4N3[H])C2([H])[H])C(O[H])=C1[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=NC([H])=NN2C([H])=C([H])C(=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2N=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C([H])=NC(=N1)C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(I)C([H])=C12
[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1F)N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[C@@]([H])(N([H])C(=O)N([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=NN=C1C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H]
[H]C1=C2C(=C([H])C3=C1C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])O[C@]31[H])C(=O)OC2([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N1C3=C([H])C([H])=C([H])C([H])=C3C(=C21)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])N1[H])C1=C(C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(Br)C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]2([H])C([H])([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(C([H])=C(S2)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1([H])[H])C1=C3C([H])([H])C([H])([H])C2=NN(C([H])=C12)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(N([H])C(=O)C([H])([H])[H])C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(C(C#N)=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(OC(=N2)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1N=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC([H])=C([H])C2=C1C(=NC2([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C(=C([H])N=C2OC1(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C(N=C([H])N=C23)N([H])[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC([H])=C2[H])=C1[H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])=C([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])OC(=O)N([H])C3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C([H])C([H])=C2S1
[H]N(\N=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C2C(=NC([H])=N1)N(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])S1
[H]C1=C(OC([H])([H])[H])N=C2N3C(=NC(=C3C(=NC2=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]OS(=O)(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=NC(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C([H])([H])S(=O)(=O)O[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NN=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=NC(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C([H])C([H])=C(C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CNC(=O)CCC1=[N+]2C(C=C1)=CC1=CC=C(N1[B-]2(F)F)C1=CC=CS1
[H]N(C1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N([H])C1=C(I)C([H])=C(C(=O)OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1OC([H])([H])C([H])([H])O2
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=C(I)C2=C1N=C([H])N=C2S[H]
[H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C([H])([H])N(C(=O)C1=C([H])C(=C([H])C([H])=C1O[C@@]([H])(C([H])([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C2([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(Cl)S1
[H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C1=C2N=C([H])N([H])C2=NC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])[C@@]2([H])N(C([H])([H])[C@]1([H])C2([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C(S1)C1=NC(N([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C([H])N=C1[H]
[H]C1=C([H])C([H])=C(S1)N1N=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C1C([H])([H])C([H])([H])[C@]2([H])[C@](C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])([H])OC1=O
[H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H]
[H]N(C(=O)C([H])([H])C#N)C1=C(C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H])C([H])([H])[H]
[H]N(\C(=C1\C(=O)N(N=C1C([H])([H])C(=O)OC([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NN(C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])O2
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])SC(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C2C([H])=C([H])C([H])=C([H])C2=C2C(=N1)C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2([H])[H]
[H]N([H])C(=O)N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H]
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2Cl)C(=O)N([H])N([H])C3=O)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C(N=C1N([H])[H])N([H])[H])C(=O)O[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(OC([H])([H])[H])=C(C#N)C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C1=C2C(=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]1(O[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C(C(F)=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C(=N2)C2=C([H])C([H])=C(F)C([H])=C2F)C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C1=NN=C2N(C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])[H])C1=O
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C([H])([H])C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N(C1=NC2=C(S1)C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(O[C@]([H])(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C(OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=NN=C(O1)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C([H])([H])C([H])([H])N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O\N=C(\C(=O)N([H])C([H])([H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(Br)=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H]
CN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)CCC1=CC=CC=C1
[H]N([H])C1=NC([H])=C([H])C([H])=C1C1=NC2=C([H])C([H])=C(N=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N1C2=C(C([H])=C([H])C(F)=C2[H])N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])[C@@]1([H])OC([H])([H])C([H])([H])[H]
[H]N(C1=NC(=NC(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])N=C([H])O2)C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C#CC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OS(=O)(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])N(N=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]\C(=C(\[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)OC([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC(=O)N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(Br)=C([H])C2=C1OC(=C([H])C2=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C2=NC3=C(C([H])=N2)C([H])=C([H])C([H])=C3[H])=C1[H]
[H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\N([H])C1=NC(=C([H])S1)C1=C([H])N([H])C(=C1[H])C([H])([H])[H]
CCCC1=NC(=NC(=C1)C1=CC(=CC(=C1)C(=O)N(C)CC1=CC=CC=C1)C(F)(F)F)C#N
[H]OC(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N([H])C1=C2C([H])([H])[C@@]2(O[H])[C@]3([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(O[C@@]12[H])C(O[H])=C([H])C([H])=C4C3([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])OC2=C([H])C(O[H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)C(F)(F)F
[H]OC(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@](C2=C([H])C(O[H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2C([H])=C([H])C(Cl)=C([H])C2=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])N=C3C([H])=C([H])C(C#CC([H])([H])N([H])C(=O)C4=C([H])N=C([H])N(C4=O)C([H])([H])C4=C([H])C([H])=C(F)C(F)=C4[H])=C([H])C3=N2)C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1(OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
COC1=CC=C(OC2=C(Cl)C=NN(CC(=O)N(C3=CC=CC=C3)C3=CC=CC=C3)C2=O)C=C1
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=NC(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C(C([H])=C1[H])[C@@]1([H])SC([H])([H])C(=O)N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C([H])=C([H])C(Cl)=C([H])C2=NC2=C1[C@]1([H])C([H])([H])C(=C([H])[C@]([H])(C2([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])Cl
[H]N1C([H])=C(C2=C1C([H])=C(F)C(=C2[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C(=O)C(=O)[C@]([H])(N([H])C(=O)C1=C(Cl)C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=NN([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)OC1=C([H])C(N([H])C(=O)OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C([H])([H])N([H])C(=O)C3([H])C([H])([H])C3([H])[H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC3=C2C([H])=C([H])C(=C3[H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C#C[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C(=C3N3C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])N([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(OC(=C2[H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(O[H])C2=C(C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=NC([H])=C2C([H])=C1[H])[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC([H])=C(N=C1[H])C1=C([H])C(O[H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)[C@]1(C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])O[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]11C([H])([H])N(C2=C([H])N=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])OC(=O)C(\C#N)=C1/S[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])N([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]12C([H])([H])C(=O)\C(=C(/[H])C3=C([H])C(I)=C([H])C([H])=C3[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C(N=C2C([H])=C([H])C(=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1=C2O[C@@]3([H])C(=O)C([H])([H])C([H])([H])[C@]45OC([H])([H])C([H])([H])N6C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C([H])([H])[C@]56[H]
[H]C1=C([H])C([H])=C2N=C(OC2=C1[H])SC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H]
[H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(OC(=O)N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C(SC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C3=C([H])C2=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=N1
[H]C1=C(N(N(\C1=N\C(=O)C1=C(F)C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(Cl)C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(C1=C([H])C([H])=C(OC2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]OP(=O)(O[H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N([H])C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NC3=C([H])N=C([H])C([H])=C23)C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@]1([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C(=NC2=C([H])C(F)=C(C([H])=C12)C(F)(F)F)C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])N2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])C1=NC([H])=C(Br)N=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@]2([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C1I
[H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NC(=C1[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2F)C([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(\C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1
[H]ON([H])S(=O)(=O)N([H])[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C(C([H])=NC(=C1[H])N1C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H])N(C(=O)C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN2C(=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])=N1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(N=C([H])C([H])=C3[H])[C@@]([H])(C3=C2C([H])=C(Cl)C([H])=C3[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(P([O-])([O-])=O)P([O-])(=O)C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)O[C@@]1([H])C([H])([H])N2C(=O)N(C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C(N=C12)C1=NN=C2C([H])=C([H])C([H])=C([H])N12
[H]N1C([H])=C([H])C2=C1N=C([H])C([H])=C2C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=O)N([H])[H])C(=C2C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])\C(=C(\[H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]OC(=O)[C@@]([H])(O[H])C([H])([H])N(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C([H])S1)C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1N=NC([H])=C1[H]
[H]C1=C([H])C([H])=C2C([H])=C3C(OC4=C(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C4([H])[H])[C@]3([H])C([H])(C#N)C#N)=NC2=C1[H]
[H]N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)N(C([H])([H])C2=C([H])C(F)=C([H])C(F)=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C1=C([H])C2=C(C([H])=C1[H])C(N([H])C2(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C(N(C(=N1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C1(N([H])C([H])([H])C(=O)N2C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]2([H])C#N)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C(C(=NN1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])SC([H])=C1[H])C(=O)C1=NC([H])=C([H])C([H])=C1[H]
[H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C2=C([H])C(C(=O)N([H])C3=C([H])C([H])=C4C(=C3[H])C3=C(C(=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C4([H])[H])=C(Cl)C([H])=N2)C([H])([H])C1([H])[H]
[H]OC1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(N([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)[C@]([H])(C([O-])=O)C([H])([H])C([H])([H])SC([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C2N([H])C(=O)N(C2=NC(=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
Cc1cnc(Nc2cccc3CCCc23)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]OC(=O)[C@]([H])(C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])=C2C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1Br)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OP(=O)(O[H])C([H])(N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C2OC([H])([H])C(=O)N([H])C2=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O\N=C(/[H])C1=[N+](C([H])=C([H])N1C([H])([H])[H])C([H])([H])O[C@]([H])(C([H])([H])[H])C([H])([H])C#C[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N([H])C(=O)C2=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1N2C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=NC([H])=C2N([H])N=C(C2=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C(F)=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C2=NN([H])C3=C2C(=NC([H])=N3)N([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(N(C(=C1[H])C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])N=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])[C@@]([H])([N+]([H])([H])[H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C3N(C(=O)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C3=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])[C@@]1([H])OC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2C2=C1C1=C(N([H])C(C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H]
[H]N([H])C1=C(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC(=N2)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])N(C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])[C@]([H])(C2=C(C([H])=NC([H])=C2[H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C(=N2)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC(=O)C1=C(N([H])C(=O)C2=C([H])C(=NN2[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])S1
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C(SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N([H])C(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])C2=C([H])N([H])C4=C2C([H])=C([H])C(Cl)=C4[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(SC2=NN3C([H])=NC(=O)C(=C3C([H])=C2[H])C2=C(F)C([H])=C([H])C([H])=C2C(F)(F)F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=NN(C(=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])[H])=C([H])C(Cl)=C1[H]
[H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(O[H])C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N=C(F)C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C([H])([H])[C@]2([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C([H])C([H])=C12
[H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(C2=NC(=NO2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(C([O-])=O)=C1C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1N([H])C(=O)C([H])([H])[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]SC([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C1([H])[H])C([H])([H])[C@@](C3([H])[H])(C2([H])[H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])C#N
[H]C1=C(C([H])=C2N1C([H])=C([H])C([H])=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(N([H])C2=NN=C([H])C3=C2C([H])=C([H])C([H])=C3C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=NC([H])=NC3=C2OC2=C([H])C([H])=C(Cl)C([H])=C32)C([H])([H])C1([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])C1([H])C([H])([H])C1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([N+]#[C-])=C([H])C([H])=N1
[H]N(C(=O)C1=NC([H])=C([H])C(OC2=C([H])C([H])=C3N([H])C(=NC3=C2[H])N([H])C2=C([H])C(Br)=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(F)(F)F
[H]N(C(=O)C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])N1N=C(N(C1=O)C([H])([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F
CS(=O)(=O)C1(CCOCC1)C1=CC(=NC(=N1)C1=CC=CC2=C1C=CN2)N1CCOCC1
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(SC([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]C1=C(F)C([H])=C(C([H])=C1N1C(=O)N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NN=C1C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
[H]N1C2=NC([H])=C([H])N=C2C(=C1C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N2C3=C(OC([H])([H])[C@]2([H])C2([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3C1=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])C1=N[C@@](C2=NOC([H])([H])C([H])([H])N12)(C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(F)N=C([H])C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(C2=C([H])C([H])=C(S2)C#CC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC(\N=C(/[H])C3=C([H])OC4=C([H])C([H])=C(C([H])=C4C3=O)C([H])([H])[H])=NC([H])=C2[H])C([H])=C1[H]
[H]OC1=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])N([C@]([H])(C4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1O2
[H]O[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])N([H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C3=C(N=C2[H])N(C2=NC([H])=C([H])C([H])=C2N(C3=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N1C(=O)N(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
NC(=S)N1N=C(CC1C1=CC2=CC=CC=C2C=C1)C1=CC=CC=C1
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C2C(SC3=C2N=C([H])N(C3=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])=NC([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N=C1N(C2=C([H])C([H])=C([H])C(Cl)=C2N1C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NN2C([H])=C(C3=NN=C(O3)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])OC([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(O[H])C(=NC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1N([H])[H])[C@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C([H])N(C2=NC([H])=N1)[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=C1[H])N(C([H])=C(C(=O)OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N1C(=O)[C@@](C2=C([H])C([H])=C(OC([H])([H])C([H])=C([H])[H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]1([H])C(=O)N([H])N([H])C(=O)C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#CC2=C(N=C([H])N=C2[H])N([H])C2=C([H])C(Cl)=C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H]
[H]N1C2=C(C([H])=C1C1=C([H])C([H])=NC(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C1[H])C(=O)N([H])C(=N2)C([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])C2=C([H])C([H])=C(OC3=C(N([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4S(=O)(=O)N([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C12
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CN1CCN(CC1)C1=CC=C(C=C1)C(=O)NC1=NNC2=C1SC(=C2)C(=O)N[C@H](CN1CCOCC1)C1=CC=CC=C1
[H]C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])[C@@]4(C([H])([H])C3([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C3=NC([H])=C([H])C([H])=C3[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(O[H])C([H])=C2[H])[C@]2([H])[S@@](=O)[C@@]1([H])C([H])([H])[C@]2([H])S(=O)(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C1\C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)C(=O)C3=C(Cl)C([H])=C([H])S3)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C3=C2C2=C([H])N(N=C2C([H])([H])C3([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C2N(C(=O)SC2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C(=C(N([H])C(=O)C2=C([H])C([H])=C3N=C(SC3=C2[H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])N1C(=O)C([H])=C([H])C2=C1C1=C([H])C(=C([H])C([H])=C1N=C2[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C([H])=C2[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@]2(OC([H])([H])C3=C2C([H])=C(C(F)=C3[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C1=NN([H])C2=C1C([H])([H])[C@@]([H])(C1=C([H])SC([H])=C1[H])C2([H])[H]
[H]N([H])C1=NC([H])=C(\C([H])=C(/[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C2=C1C(=C([H])S2)C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])=C1[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=NC([H])=C2C#N)C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1
[H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C(=O)[C@]1([H])ON=C(C2=C(N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C1=C(C([H])=NC2=C1C([H])=NN2C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])N(C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O)C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=NC(=C([H])C(=O)N1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
COC1=CC=C(C=C1)C1=NN(C(C1)C1=C2C=CC=CC2=CC=C1)C(N)=S
OC(=O)CN1CCN(CC1)C1=CC2=C(OC(=N2)C2=CC=C(C3=CC=CC=C3)C(=C2)C(F)(F)F)C=C1
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
O=C(NC1=CC=CC(=C1)C1=CC=CO1)N(CCC(C1=CC=CC=C1)C1=CC=CC=C1)CCN1CCOCC1
[H]N(C1=NN(C2=C1C([H])=NC(=N2)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=NC(=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N2C(=O)C([H])([H])[C@@]2([H])S(=O)(=O)[C@]1(\C([H])=C(/[H])C([H])([H])OC(=O)N([H])[H])C([H])([H])[H]
[H]OC1=C(C(=C([H])C([H])=C1N([H])C(=N\C#N)\N([H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N([H])C(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C2N=C(C([H])=C([H])C2=C1[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CC(C)(COC1=C(C=C(C=C1)C1=NC(N)=NC(O)=C1)C#N)C(O)=O
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC([H])=C([H])S2)[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]N1C(=NN(C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C3=NC(=C([H])C(=C3N=C2C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[S@]1=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H]
COCCCN1CCC(CC1)N1CCC(CC1)N1N=C(C2=C(N)N=CN=C12)C1=CC=C(NC2=NC3=C(O2)C(Cl)=CC=C3)C=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(O[H])C([H])=C(O[H])C([H])=C2OC1([H])[H]
[H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=O)C2=C1C([H])=C([H])C(=C2[H])[N+]([O-])=O
[H]N(C1=NC([H])=C2C([H])=C([H])N(C2=N1)C1=C(F)C([H])=C([H])N=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[C@]3([H])OC([H])([H])C([H])([H])C3([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1[C@]1([H])N(C2=O)C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C(=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
O=C(CCCCC1CCSS1)N1CCN(CC2CCCCC2)CC1
[H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3C3=C2C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])\C3=N/OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=NC(OC([H])([H])[H])=N1)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OS(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])SC([H])([H])[H]
CC1=C(Cl)C(=NN1CC(=O)N1CCN(CC1)C1=CC=CC(C)=C1)C(F)(F)F
[H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@@]([H])(C2=C(C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]OC1(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])OC3=NOC4=C3C(O[C@@]3([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OP(=O)(O[H])[C@]([H])(C(=O)N([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C1=NC([H])([H])C([H])([H])N1C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=C([H])[H])C(=O)N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC([H])([H])C1=C(N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(S1)C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1O[C@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])S(=O)(=O)C([H])([H])[H]
CC1=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C(NC(=O)C2CCOC2)C(F)=C1
[H]N([H])C1=N[C@]([H])(C2=C([H])C([H])=C([H])O2)C([H])([H])C2=C1SC([H])=C2[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC3=C(N=C([H])N3[H])C(=N2)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NN(C(=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C(C([H])=C(C(Cl)=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N(C([H])([H])C1=C([H])N([H])C2=C1N=C([H])N([H])C2=O)C([H])([H])C([H])([H])C([H])([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
CCCCCC1=C(C(=O)OCC)C(C(=O)OCC)=C2N1N=C(C=C2C1=CC=CC=C1)N1CCOCC1
[H]O[C@]([H])(C([H])([H])OC1=C2C(N([H])C(=O)C22C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])Cl)C([H])([H])C([H])([H])[C@@]21[H]
[H]O[C@@]([H])(C1=C([H])SC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(N=C2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C(Cl)C([H])=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)N([H])C2=C1C([H])=C([H])C(=C2[H])C1=NC2=C(C([H])=NN2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])(N2C(=O)OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=NN2C(=N1)C1=C(N=C2N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=NN1C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C1=NC(=C([H])S1)C([H])([H])C1=NN=C(SC([H])([H])C2=NN=C(S[H])N2N([H])[H])N1N([H])C(=O)C([H])([H])[H]
COC1=CC=CC(=C1)C1=CC=C(S1)C(=O)N(C)C1=CC=CC(=C1)C(F)(F)F
[H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C(Cl)=C2[H])[C@]2(C1=O)[C@]([H])(N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])N1C([H])([H])[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C2C(OC([H])=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C(=C([H])C([H])=C3F)C(F)(F)F)C([H])=C2[H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H][C@@]12CC[C@@]3(C)[C@@H](C[C@@H](Cl)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)C1=COC=C1)C(=O)OC
[H]C1=NC(=C([H])C([H])=C1[H])[C@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=NC(=C([H])C([H])=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)[C@@]3([H])OC([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3=C2C2=C(N(N=C2[H])C([H])([H])[H])C([H])([H])C3([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]1([H])OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]2([H])O[C@]([H])(OC([H])([H])C2([H])[H])\C([H])=C([H])\C(C([H])([H])[H])(C([H])([H])[H])[C@]2(O[H])O[C@]([H])(C([H])([H])\C(=C(\[H])C(=O)OC([H])([H])[H])[C@]2([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N1C(SC([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1O[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=O)N(C1=O)C([H])([H])C([H])([H])C(=O)O[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C(C([H])=C1C1=NC(=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C#N)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C(F)=C1Cl)C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])SC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C11C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])OC([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]O\N=C(/[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C(O[H])C(F)=C2[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C2=C(S1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C1=C2N=C([H])N=C(N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C3[H])C2=C([H])C(N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])=C1OC([H])([H])[H]
[H]OC1=C(C([H])=C([H])C(=C1[H])C1=C([H])C2(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])O1)S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C1=NN2C(=NN=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C2C([H])=C([H])C([H])=C([H])N12)C(F)(F)F
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])=NC([H])=C2[H])C2(OC3=C(Cl)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)[C@]2(N(C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
[H]O[C@](C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])C(C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C2N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=NC1=C2C(=NN(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NN(N=N1)C([H])([H])C([H])([H])C#N
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(C2=C1C(=NC([H])=N2)N([H])[H])[C@@]1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(Cl)C(=O)N(C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])C(=O)N(N(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=C(F)C2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C4CCC5(NC(=O)NC5=O)C4=C3)C2=O)C=C1
[H]OC1=C([H])C([H])=C([H])C2=C1C1=C(N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]2([H])O[H])C2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C2=C1C(=O)N(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C2=O
[H]N1C(=O)C([H])=C([H])C2=C1C([H])([H])[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]2(\N=C(/[H])\C(=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C1=C(/[H])C([H])([H])[H]
CCOC(=O)N1CCC(CC1)N1CCC[C@H](C1)NC(=O)C1=CC(Br)=CC(Br)=C1
[H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])O\N=C(/C2=C([H])C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C([H])([H])C([H])([H])[H])C(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C([H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C(=O)N([H])C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]([H])(Cl)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])C([H])([H])[C@]([H])(O[H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N/C(=O)C([H])([H])C([H])([H])[H])\N([H])[H]
[H]O[C@]1(C([H])([H])N([H])C(=O)C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2OC([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])C1=C(SSSC2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C(=O)O[H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])C1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(SC3=NN4C([H])=C([H])C([H])=C4C(=N3)N([H])C3=NN([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])OC1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N1C2=C([H])C(=NN2C2=C([H])C([H])=C([H])C([H])=C2C1=O)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])N([H])C([H])([H])C([H])([H])C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)[C@]1([H])[C@@]([H])(SC([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1N=NC2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=O)C(=O)N([H])[H])C(=C2C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=O)N(C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[H]
[H]OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C(=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
OC(=O)C1=CC2=C(OC(=C2C#CC2=CC(F)=CC(F)=C2)C2=CC=CC=C2)C=C1O
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=N1
[H]O[C@]12C([H])([H])C([H])([H])C(=O)[C@]3([H])OC4=C5C(=C([H])C([H])=C4OC([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@@]235
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1\C(=O)N=C2SC([H])=C(N2C1=N[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H][C@@]12C[C@]1([H])N([C@@H](C2)C#N)C(=O)[C@@H](N)C1=CC=C(C=C1)C1=CC=CC=C1
[H]N([H])C(=O)C1(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C(N2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C2C([H])=C([H])N(C3=NC([H])=C([H])S3)C2=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]O[C@]([H])(C1=C([H])C(N([H])S(=O)(=O)C([H])([H])C(F)(F)F)=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(O[H])=C([H])C(=C2O1)C([H])([H])[H]
OC(C1=CN=C(S1)N1CCC(CC1)C1=CC=CC(F)=C1)(C(F)(F)F)C(F)(F)F
[H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N(C1=C([H])C(OC(C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C(F)(F)F
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N([H])C3=C([H])C([H])=C(C#N)C([H])=C23)C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(Cl)=NC2=C1N=C([H])N2C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C2=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N([H])N([H])C(=O)SC([H])([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)N(C2=NN(C([H])=C2[H])C2=C3C(=NC(=C2[H])C([H])([H])[H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C(N([H])C(=O)[C@]2([H])N(C(=O)C3=C([H])C4=C(N=C([H])N4[H])C([H])=C3C(=O)N([H])C([H])([H])[C@]34C([H])([H])[C@@]5([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C5([H])[H])C3([H])[H])C4([H])[H])C([H])([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C1[H])C(=O)O[H]
[H]OC1=C([H])C([H])=C([H])C2=C1N([H])C1=C2C2=C(C(=O)N(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=N3)C2=O)C2=C1N(C1=C2C([H])=C([H])C([H])=C1O[H])[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C2=C(Cl)C([H])=C(F)C([H])=C2[H])C(Cl)=C1[H]
CC(C(=O)OCCON(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1
[H]C1=C([H])C(=C([H])C([H])=C1C#CC([H])([H])[N+]1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C#CC([H])([H])[N+]2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C3=C([H])C(Cl)=C([H])C([H])=C3SC2=C1[H])C([H])([H])C([H])([H])C([H])([H])[S+](C([H])([H])[H])C([H])([H])[H]
CC1=C([C@H](N2N=CC=C2N1)C1=CC=C(Cl)C(Cl)=C1)C1=NC=NN1C1CCCCC1
[H]N(C(=O)C([H])([H])N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])C2=C([H])N([H])C([H])=C2[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@](N([H])C(=O)O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC(=O)C4=C([H])C(Cl)=C(N([H])[H])C([H])=C4OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
O=C(CCCC(=O)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)C1=CC=C(OC2=CC=CC=C2)C=C1)N1CCCN(CC1)C1(C(=O)NC(=O)NC1=O)C1=CC=C(OC2=CC=CC=C2)C=C1
[H]OC(=O)C([H])([H])[C@@]1(O[H])C2=C(O[C@@]([H])(C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(F)=C2[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C(=C([H])N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C1[H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C2SC([H])([H])C([H])([H])C2=NN1[H]
[H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3OC([H])=C([H])C3=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N([H])C([H])([H])[C@@]([H])(N([H])C1([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N1C(=O)C([H])=C(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]O[C@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(F)C([H])([H])C2([H])[H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C(=NC3=NC(=C(C([H])=C13)C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C3=C(N=C2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(O[H])=C2O[H])C([H])=C1[H]
[H]OC(=O)C1=C(O[H])C(=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(O[H])=C2O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(C([H])=C2C(=O)C([H])([H])[H])C(=O)C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2F)N2C([H])=C([H])C([H])=C([H])C2=O)C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C(Cl)S2)C1([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C(F)C2=NC(=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=NC(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=N1)C(OC([H])([H])[H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=C([H])C(C#N)=C(C#N)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C(=NC(=N1)N1C([H])=NC(=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(O[H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(O[H])=C2O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
C[C@@H](OC[C@]1(CC[C@@H](CN1)NC1=NCCO1)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)C1=CC(CC2=NN=C(S2)C2=CN=CC=C2)=CC=C1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C2N=C3OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C2=C1[H]
[H]N1C([H])=C([H])N=C1C1=NC(=NC2=C1SC([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C#N)=C(C([H])=C1N1C(=O)N(C([H])([H])[H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N1N=C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])N=C1[H]
[H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(C(=O)[C@@]21[H])C1=C([H])C([H])=C(Br)C(=C1[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C3=C2N=C([H])N3[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)S(=O)(=O)C1=C([H])C([H])=C([H])S1
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NC(=N1)C1=C([H])C(=NC([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C(Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(/C1=C([H])C2=C(OC([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H]
[H]N(C1=C([H])C(N([H])C([H])([H])[H])=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[P@@](=O)(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])O1)C(=O)N([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])O[H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC2=C(SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(C([H])=C([H])C(=O)O3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C3=C(Cl)C([H])=C([H])C([H])=C3Cl)[N+]([O-])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H]
[H]N1N=C2C3=C(SC(=C3C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(F)C([H])=C2C(=C1[H])C1(C(=O)N(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
C1CCC(CC1)C1=CN=C2C=NC3=C(C=CN3)N12
[H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=C(N(N=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(=C([H])N=C12)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(C(=O)C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]C([H])=C(C([H])([H])[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C3=C(C([H])=C2C1=O)C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
COC1=CC=C(C=C1)C1=CSC(=N1)N1N=C(CC1C1=CC2=C(OCO2)C=C1)C1=CC=C(Br)C=C1
[H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1C2=C(N=C1C(F)(F)F)C(=NC(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])SC2=C([H])C([H])=C([H])C([H])=C2N(C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C(O[H])=C(Cl)C([H])=C1N1C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N([H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C1=NN=C(S1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
CN(C)C(=O)C1=CC(CN2CCC3=CC4=C(C=C3CC2)N=C(N)S4)=CC=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])=C(C([H])=C2C#N)C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=O)OC([H])([H])[C@]2([H])C3=C([H])C(=O)C(SC([H])([H])[H])=C([H])C([H])=C3C3=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C(F)=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)N=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H]
[H]N(C1=C([H])C([H])=C2N(N=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=NN2C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C(=O)C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]O[C@@]([H])(C([H])([H])O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1C#N)C([H])([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N([H])C1=N[C@]([H])(C([H])([H])C2=C1SC([H])=C2[H])C1([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)SC([H])([H])[H]
[H]ON([H])C(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(\N=C1/C(=O)N(C2=C(Cl)C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2F)C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C(N2C([H])([H])C([H])([H])N(C(=O)[C@]3([H])C([H])([H])N(C([H])([H])[C@@]3([H])C3=C([H])C(F)=C([H])C([H])=C3F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C2C(=N1)N(C(=O)C([H])=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(C1=NN=C2N1C([H])=C(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C2N([H])C(=O)C(=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])F)C([H])([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H]
[H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC([H])=NC(=C2[H])C2=C([H])SC([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C(O[H])N=C(C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N(C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])N1N=NC(=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])C1=C(C2=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@]1([H])O[C@@]1([H])C1=C2N=C([H])C(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C2=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2C2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)N1C([H])([H])[H]
OC1=CC=CC(=C1)C1=NC2=C(C=CC=C2)N1C1=CC(N[C@@H]2CCCNC2)=NC=C1
[H]OC(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N=C(C(C(=O)N([H])[H])=C1N2[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C([H])N2[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)=NC2=C([H])C(F)=C(C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])ON=C(C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H]
[H][C@@]12CCCO[C@]1([H])C1=CC(OC3=C(Cl)C=CC=C3)=CC=C1N[C@@H]2C1CCCCC1
[H]N(C1=C([H])C(=NC([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]\C(C1=C([H])C([H])=C(F)C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])C3([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(O[H])C([H])([H])N2N=C(C3=C2C([H])([H])C([H])([H])N(C3([H])[H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C(=NC3=C2C(=O)N([H])C(=O)N3C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC(Cl)=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])=C([H])[C@@]2([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(O[C@@]12[H])C(=C([H])C([H])=C4C3([H])[H])C(=O)N([H])[H]
[H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC3=C(N([H])S(=O)(=O)C4=C(Cl)C([H])=C(Cl)C([H])=C4[H])C([H])=C(C([H])=C3[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C12
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OP(=O)(O[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C([H])C(F)=C(OC([H])([H])[H])C([H])=C2[H])=N1
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C(F)(F)F
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])N([H])C(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C2C([H])=C(Cl)C([H])=C([H])C2=NC(=N1)C(=O)N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(C#N)=C([H])C([H])=C1[H]
[H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C(F)C([H])=C23)C([H])([H])[H])C1=O
[H]O[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C([H])([H])O[P@](=O)(O[H])O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@](=O)(O[H])O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@](=O)(O[H])O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@](=O)(O[H])O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@](=O)(O[H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])S[H])N1C([H])=C(C(=O)N([H])C1=O)C([H])([H])[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])[H])N1C([H])=NC2=C1N=C(N([H])[H])N([H])C2=O)N1C([H])=NC2=C1N=C(N([H])[H])N([H])C2=O)N1C([H])=NC2=C1N=C(N([H])[H])N([H])C2=O
[H]N(C(=O)[C@]([H])(N1C(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N2C(S1)=NC(Cl)=C2S(=O)(=O)N1C([H])=C([H])C2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC([H])=C(Br)N3C([H])=C([H])N=C23)C([H])([H])C1([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(F)=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2OC1=N[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F)C1=C([H])C(OC2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C(F)=C([H])C([H])=C4[H])C(Cl)=C3[H])=C2[H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)C1=C(C([H])([H])SC2=NN=NN2C([H])([H])[H])C([H])([H])O[C@@]2([H])N1C(=O)[C@@]2(OC([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1O[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C2=NC([H])=C([H])C([H])=C2[H])[C@@]2([H])C(=O)[C@]1([H])C([H])([H])N(C([H])([H])[H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N=C(N([H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])OC([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C4C(=O)N([H])C([H])([H])C4=C4C5=C(C([H])=C([H])C([H])=C5[H])N(C4=C23)C([H])([H])C([H])([H])[C@@]1([H])O[H]
[H]OC(=O)C([H])([H])C1=C(N2N=C(C([H])=C([H])C2=O)C2=C3C([H])=C([H])C([H])=C([H])N3N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(F)(F)F)C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=C2N(C(=O)N(C(=O)C2=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C2N(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C(=O)OC([H])([H])[C@@]1([H])N(\[N+]([O-])=N\OC([H])([H])OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H]OC1=C([H])\C(=N\C2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C3=NC([H])=N2)C(=O)C([H])=C1OC([H])([H])C([H])=C([H])[H]
[H]N1N=NC(=N1)C1=NN=C(S1)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C(F)=C([H])C([H])=C2Br)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Br)=C1[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[H])C(=N1)N([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N([H])N=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])N2N=C(N=C12)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(N=C([H])C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2C(=O)C(=NC(Cl)=C2C([H])([H])[H])N([H])C2([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])=C1[H]
[H]N1C(=O)C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])SC(=N1)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN2C(=N1)C([H])=C([H])C([H])=C2C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])N=C(N=C2OC2=C([H])C([H])=C([H])C([H])=C2[H])N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)N1[C@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])OC([H])([H])[C@]1([H])C1(OC(=O)N2C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
CN1CCC(COCC2=NC(=CC(=C2)C(F)(F)F)C2CC2)(CC1)C1=CC=CC(F)=C1
[H]O[C@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])[C@]5(C([H])([H])[C@@]35C(=O)C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])[C@@]([H])(N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N=C(SC([H])([H])[C@@]41C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H]
[H]N(\C(=C1/C(=O)N([H])C(=O)N(C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(SC2=C1N=C(N=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C1=NC(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C(SC2=N1)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NC(C2=C([H])C([H])=C([H])O2)=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]SC([H])([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]C([H])=C([H])C([H])([H])N1C(=S)N([H])N=C1C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]N([H])C1=NC([H])=NN2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C(N([H])[C@@]([H])(C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])[N+]([O-])=O
[H]N([H])C(=N\C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(N([H])[H])C(=O)N([H])[H])\N([H])[N+]([O-])=O
[H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C1=C([H])N(N=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)N([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C(OC2=C([H])N=C([H])C([H])=C2[H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]11C(=O)N([H])C(=O)N([H])C1=O
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NO[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]([H])(C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1[H]
CC1=CC(Cl)=C(OCCOC2=CC=C(C=C2)[C@H]2CCNC[C@@H]2C(=O)N(CC2=CC(CNCCF)=CC=C2Cl)C2CC2)C(Cl)=C1
[H]C1=C([H])C([H])=C(S1)C(=O)N1C([H])([H])C([H])([H])OC2(C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C([H])C(=C([H])N=C1N([H])C1=C([H])C([H])=C(N=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C2=C1C(=C(C(=O)O2)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=NC([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)ON=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1C([H])([H])C([H])([H])Cl)C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NN(C2=C1C([H])=C([H])C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])N(C(=O)C3=C(N=C([H])N=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])O[C@@]([H])(OC2=C([H])C([H])=C3C(OC(=O)C([H])=C3C([H])([H])[H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C1=C(C(=NC2=C([H])C([H])=C(Cl)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])C1([H])[H]
[H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@]1(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])=C(C([H])([H])OC(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])[C@@]2([H])OC([H])([H])O[C@@]2(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C(=NN2C2=C([H])C([H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C23)C(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(=NC2=C1C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])C2=C(Cl)C([H])=C([H])C(Cl)=C2C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C(N([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H]
CCCC1=NC(=NC(=C1)C1=CC(=CC(=C1)C(=O)N(C)C)C(F)(F)F)C#N
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1\C([H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(\C([H])=C2/N([H])C(=O)N(C2=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C(Cl)=C([H])N12)[C@@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
COC1=C(OC)C=C2C=C(C(=O)OCC3CCN(CC4=CC=CC=C4)CC3)C(=O)OC2=C1
[H]C1=C([H])C2=C(C(=NC2([H])[H])C2=C([H])C(=NC([H])=C2[H])C(F)(F)F)C(OC([H])([H])[H])=N1
[H]C1=C([H])C([H])=C([H])C(=N1)C#CC1=C([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
CC(C)C1=CC=C(NC(=O)OC2=CC=C3N(C)C4[C@@](C)(CC[N]4(C)C)C3=C2)C=C1
[H]N(C(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1N2[H])C([H])([H])N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])F
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N([H])C1=NC([H])=NC(N2C([H])([H])C([H])([H])N(C(=O)N([H])C3=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1\C([H])=N\OC([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H]
NC(=O)C1=C(N(CC(F)(F)F)C(=C1)C1=CC=NC(N)=N1)C1=CC=CC=C1
[H]N([C@]1([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C1([H])[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1F
[H]C1=C([H])C([H])=C(S1)S(=O)(=O)\N=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([O-])=C1[N+]1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])[C@@]([H])(C2([H])[H])[C@]1([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N(C(=O)C([H])([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1(C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
[H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])N2C(=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=NC([H])=C1C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])OC1=NC(C#N)=C([H])C(=N1)C([H])([H])[H]
[H]OC1=C(C([H])=C(OC2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[C@]2([H])N([H])C(=O)N([H])C2=O)C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(=O)N([H])[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(\N=C2/SC(=NN2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(F)=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1Cl)C([H])([H])OC([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)[C@@]1([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N(C(=C([H])C2=C1[H])C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2OC1=O
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C(F)C(F)=C([H])C([H])=C4[H])=C3C([H])=C2OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(O[H])=C1C1=C([H])C(N=C=S)=C([H])C([H])=C1[H]
[H]C1=C2C(N(C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])[C@]2([H])C([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])N=N1
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C([H])=C4C([H])=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C4=N3)C([H])([H])[C@@]12O[H]
[H]N(C1=NC(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2N([H])C(=O)C1([H])[H]
[H]N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=O)C(=O)N([H])[H])C(=C2C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(N([H])C(=N/C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])\N([H])C#N)=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(N=C([H])N2C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(=N1)C1=C([H])C([H])=C([H])O1
[H]C1=NC([H])=C2C([H])=C([H])C(OC([H])([H])[H])=C([H])C2=N1
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H]
[H]O\N=C(/[H])C1=[N+](C([H])=C([H])N1C([H])([H])[H])C([H])([H])O[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)[C@@]([H])(N(C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C([H])([H])SC([H])([H])C([H])([H])C1=NSN=C1O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C(=N2)C([H])([H])N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H]
[H]C1=NC(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N2N=C(N=C2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1N=NC(=N1)N(C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)[C@]1([H])C2=C([H])C(=C([H])C([H])=C2N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C(F)(F)F
[H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N1C2=C([H])C([H])=C(C#N)C([H])=C2C([H])([H])[C@@]([H])(N(C([H])([H])C2=C(Br)C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=N2)C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([O-])=O
CCCCN1CCC(COC(=O)C2=C(OC)C=C(N)C=C2)CC1
[H]ON([H])C(=O)C([H])([H])[C@@]1(N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=NC([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)C([H])([H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H]
[H]N1N=C(C2=C(N3C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])C3=C([H])C(OC([H])([H])[H])=C([H])C(=C3N=C12)C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]12N(C([H])([H])C3=C([H])C([H])=C([H])C(Br)=C3[H])[C@]3([H])[C@@]4([H])[C@]5([H])[C@]([H])([C@@]14[H])[C@@]1([H])C([H])([H])[C@]5([H])[C@]3([H])[C@@]21[H]
[H]OC([H])([H])C1=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N(C3=C2C(=NC([H])=N3)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])F
[H]N(C(=O)C1=C([H])C2=NC([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C2C([H])=NN(C2=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
O=C(CC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1)C1=CC=C(C=C1)[N+]#[C-]
[H]N(C(=S)N([H])C1=C(C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])O1
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[P@](=O)(O[H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)NC1=CC=C(OC2=CC=C(NC(=O)N3CC[C@@]4([H])CC[C@H](N4C(=O)[C@H](C3)NC(=O)[C@H](C)NC)C(=O)NC(C3=CC=CC=C3)C3=CC=CC=C3)C=C2)C=C1)NC(=O)[C@H](C)NC)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1
[H]N(C1=NC2=C(C([H])=N1)C([H])([H])C([H])([H])C1=C2SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H]
[H]O[C@@](C1=C([H])N=C([H])C([H])=C1[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C(N=C([H])N3C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
CCC1=CC2=C(CC(C2)NC[C@H](O)C2=C3CCC(=O)NC3=C(O)C=C2)C=C1CC
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C(=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(Cl)C([H])=C2N2C1=NN=C2C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C1=NN=C([H])N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(N=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=NC(=O)C([H])([H])N1C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C(F)C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F
[H]C1=C(C([H])=C(C(C#N)=C1[H])C(F)(F)F)N1C(=O)[C@@]2([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C1=O
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F
[H]N1C(=NC2=C1C([H])=C([H])C(Br)=C2[H])C([H])([H])OC1=NN(C(=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C(=C([H])C2=C1[H])C([H])([H])N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])N=C([H])C([H])=N2)C(Cl)=C1[H])C1=NC([H])=NC2=C([H])C([H])=C([H])C(O[C@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C12
[H]N(C(=O)[C@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(N=C(C([H])=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(C#CC(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[O-]C(=O)C(F)(F)F.CC1=NC2=C(OCC3=C(Cl)C=CC(=C3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCC(CCCC[N+](C)(C)C)CC3)C=CC=C2C(C)=C1
[H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C1=NC([H])=C(S1)C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C(=O)O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N(C1=C(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(C1=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3(O[H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C(Cl)C([H])=C(OC(=O)C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@](OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C(OC2=C(OC([H])([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC([H])=C([H])N2C1=NC(=C2C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC(=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([O-])=O
[H]S\C(=N/N=C(/C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1SC(=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(\N=C1\C2=C(N([H])C(=C2C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=S)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OC1=C(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=NC(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1C#N
[H]N(C(=O)N([H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=NC2=C(C([H])=C([H])C([H])=C12)C([H])([H])[H])C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])S1(=O)=O
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=N[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[C@]2([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])([H])O2)C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(OC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(N1C([H])([H])C([H])([H])Cl)C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)N1S(=O)(=O)C2=C(C([H])=C([H])C([H])=C2[H])S1(=O)=O
[H]OC1=C(O[H])N=C2C(=N1)C([H])=C(F)C(=C2[N+]([O-])=O)C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])N1C([H])=NC([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Br)C([H])=N1
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=NC([H])=C([H])S2)C([H])([H])[H])C([H])=C1C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(\C(S1)=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C3[H])=N1)C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])N([C@]([H])(C4=C([H])C([H])=C(I)C([H])=C4[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C2=C(N([H])C(=N2)C2=C([H])C([H])=C(Br)S2)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O
CC1=NC=CC(COC2=CN=C(N=C2)N2CCN(CC2)C(=O)OC(C)(C)C)=C1
[H]N1N=C(N=C1C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C1[H]
[H]N([H])C(=O)[C@]1([H])N(C([H])([H])C2=C(OC([H])([H])[H])C([H])=C3N=C([H])N=C(N([H])C4=C(F)C(Cl)=C([H])C([H])=C4[H])C3=C2[H])C([H])([H])[C@]([H])(OC([H])([H])[H])C1([H])[H]
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(N)=O
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])N=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C(=O)[C@@]1([H])C2([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
CNC(=O)C1=CC=CC=C1NC1=C2C=C(NC2=NC=C1C(F)(F)F)C1=CC=C(C=C1)N1CCOCC1
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]([H])(\N=C(/S[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)O[H]
[H]N(C1=NC(=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(OC(C3=C([H])C([H])=C([H])O3)=C2C2=C([H])C([H])=C([H])O2)=NC([H])=N1
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=NC2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C#C[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@]3([H])N(C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C3C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=O)C(=O)C3=C(OC(=C3C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C2=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])OC(OC1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C2=C1C([H])([H])C1=C2C([H])=C(Cl)C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)O[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C([H])=C1[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#CC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]([H])(N(C1=NN(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
COC1=CC=C(OC2=C(Cl)C=NN(C2=O)C2=NC3=C(OC4=C2C=CC=N4)C=CC(Cl)=C3)C=C1
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C(=NC([H])=N2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N(C([H])([H])[H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1Cl)C(=O)OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC(=O)C3=C([H])C(Cl)=C(N([H])[H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=S)N([H])\N=C(\C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])S1)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC(=O)C1=C(N([H])[H])C([H])=C(O1)C1=C([H])C([H])=C([H])C(Cl)=C1[H])N([H])[H]
[H]N1C(=O)C([H])([H])[C@@]2(C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C(F)C([H])=C3[H])S1(=O)=O
[H]N=C(N([H])[H])C1=C([H])C2=C(C3=C([H])N([H])N=C3[H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C13)C([H])([H])[C@]1([H])N(C3=C(C([H])=C([H])C([H])=C3[H])C1([H])[H])C2([H])[H]
[H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C([H])C(=O)N(C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H])C(=N/OC([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@@]2(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C(=O)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(SC([H])([H])C([H])([H])C([H])([H])[H])=N2)C([H])([H])C1([H])[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[S@](=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)[C@]2([H])ON(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])C1=O
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])N([H])C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)O2)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])[H]
[H]OC1=NC2=C([H])C([H])=C(C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]C1=C([H])[N+](=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C([H])=NC2=C([H])C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])C1=NOC(=N1)C1([H])C([H])([H])C([H])([H])N(C(=O)N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C(Cl)C([H])=C2C(=O)N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C(=NC2=C1C([H])=C([H])C([H])=C2C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[S@](=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)N2C([H])=C([H])N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(=C1[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC2=C3C(=C([H])C([H])=C2[H])N(C([H])=C3C([H])([H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])C([H])([H])C3=C2[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2N=C(C(=C2[H])C2=C([H])C([H])=C3C4=NN([H])C([H])=C4C([H])([H])C3=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H]
[H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
[H]C1=C([H])C(=C(C([H])=N1)C1=C([H])C2=C([H])C([H])=C(C#N)C([H])=C2C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C(=O)C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C2=C1[H]
[H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])ON=C3C4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C4OC([H])([H])[C@@]23[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
CCN1C(CNC2=C(C)C=C(C)C=C2)=NN=C1SCC(=O)NC1=CC=C(C)C=C1
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NO[C@]2([H])C2=C([H])C([H])=C(F)C([H])=C2F)C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=CC=C(\C=C\C2=C(/C=C/C(=O)N3CCCCC3C)C(OC)=CC(OC)=C2)C=C1
[H]OC([H])([H])C(=O)[C@@]1(OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3(F)[C@@]([H])(O[H])C([H])([H])[C@]12C([H])([H])[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H]
COCCC1(CCCC1)C(=O)N[C@@H](CC1=CC=C(C=C1)C1=C(C)N(C)C(=O)N(C)C1=O)C(O)=O
[H]C([H])=C([H])C([H])([H])N1C(=C([H])C(C(=O)C([H])([H])OC2=C(N=C(C([H])=C2[H])C([H])([H])[H])[N+]([O-])=O)=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC(=N1)C1=C(C2=C([H])C([H])=C([H])C([H])=C2O1)C([H])([H])[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N=C(N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[C@@]([H])(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])C(O[H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]\C(=N/N1C(=O)C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]OC1=C2\C(=C(\[H])N(C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])O[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3N=C2O1
[H]O[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C([H])([H])OP(=O)(O[H])O[H])N1C([H])=C(C(=O)N([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C(C(=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(S1)S(=O)(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H])C1=NN=C(S1)C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N([H])C(=NC2=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=NC([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H]
[H]C1=C2N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=NC1=C2C(=NN(C1=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
O=C(N1CCCC1)C(=O)C1=CN(C(=O)C2=CC=CC=C2)C2=CC=CC=C12
[H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2N([H])C(=S)N3[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N1N=C(C2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]OC1=C(N([H])C2=NSN=C2N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(F)=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1Cl)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1C1=C([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1
[H]O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C3=C([H])C([H])=C(O[H])C(=C3O[C@]2([H])C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
NC1=CC=C(OC2=CC=C3COB(O)C3=C2)C=C1
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
FC1=CC=C(CN2C(NC(=O)C3=CC=CC(=C3)C#N)=NC3=CC(=CN=C23)C(=O)N2CCCCC2)C=C1
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=O
[H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(OC([H])([H])[H])N(C3=C([H])C([H])=C2[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
CN(C)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(C=C1[N+]([O-])=O)S(=O)(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=CC(=CC=C1)C1=CN=CN1C1=CC=C(Cl)C=C1
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])N1C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])O1
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C(Br)=C1C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C(=C2[H])C([H])([H])N(C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])N1N=C([H])C([H])=C1[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])[N@@+]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H])[N+]([H])([H])[H]
[H]N1C2=C(N=C(C([H])=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N(C2=C([H])C([H])=C(OC([H])([H])[H])N=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])O[C@@]2([H])[C@@]([H])([N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1Cl)S(=O)(=O)N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1(C2=C([H])C([H])=C([H])C(SC3=C([H])C([H])=C(C([H])=C3[H])N3C([H])=NN=C3[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1N=C([H])C2=C(N([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C12)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=NC([H])=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C1=NC([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C2([H])C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C(=NC2=C(Br)C([H])=NN12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
ClC1=CC=C(C(C2=NC3=CC=CC=C3N2)=C2C(=O)NC3=C2C=CC=C3)C(Cl)=C1
[H]N(C1=C2C([H])=NN(C2=NC([H])=C1C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C#CC([H])([H])N1C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1=O)C([H])([H])[C@]1([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON(C(=O)N([H])[H])[C@@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(N([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])S[H])=C2[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(S1)C1(C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C1=O)C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=NC(Br)=C1[H]
[H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)[C@]1([H])OC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C(C#N)C([H])=C4[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C2C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(O[H])=NC1=C([H])C([H])=C([H])C([H])=C21
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N1C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C(C([H])=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])N(C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)C([H])=C2C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(N=C3C2=C([H])C([H])=C(F)C([H])=C2F)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1N([H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]OC1(C(=O)N([H])[C@@]([H])(C2=C(F)C([H])=C(C([H])=N2)C2=C([H])C(Cl)=C([H])C(F)=C2C2=NN(N=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=NO1)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC(=O)C1=C([H])C([H])=C(O1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])N([H])[H]
[H]OC1=C2O[C@@]3([H])C(=O)[C@]4(C([H])([H])C5=C(C([H])=C6C([H])=C([H])C([H])=C([H])C6=C5[H])C4([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N(C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N([H])C(=N/C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=C1[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC(=C(S1)C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2C([H])=C([H])C([H])=C([H])C2=NN1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N=C2C([H])=C(C([H])=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C1=NN=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C2=C1N=C(C([H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(O[H])=C1[H]
[H]C1=C(C2=NSN=C2SC([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N2C(SC(Cl)=C2Cl)=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C([H])([H])O[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]ON(C(=O)N([H])[H])C([H])([H])C#CC1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])O1
[H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C(=S)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H]
[H]N(C(=O)[C@]([H])(N1N=C(C([H])=C([H])C1=O)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1)[C@]([H])(C(=O)N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C(F)C([H])=C3[H])C2=C(N=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])OC1=C2N=C([H])N([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(OC2=NC(OC3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])=C([H])C([H])=N2)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C([H])([H])SC([H])([H])[C@]1([H])C(=O)N1C([H])([H])SC([H])([H])[C@]1([H])C([H])(OC([H])([H])[H])OC([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(N([H])C(=O)N([H])C3([H])C([H])([H])C3([H])[H])C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
COC1=NC(=NC(C)=C1F)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=CC=C(F)C=C1Cl
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])SC([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(F)C(=C(Cl)C([H])=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C(=O)N([H])C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])N2C(=NC(=NC2(C([H])([H])[H])C([H])([H])[H])N([H])[H])N([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@@]1([H])OC1([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C1=C([H])C([H])=C(OC2=C([H])C(=C(Cl)C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N(C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=NC([H])=NC2=C1SC1=C2C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C(OC([H])([H])C#CC([H])([H])C([H])([H])[H])=NC2=C(C1=O)C(=C([H])C(=O)O2)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C(C([H])=C(C#CC([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])=C2N1[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(O[C@@]3([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C(S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NN=C(O1)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(OC([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])=NC([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2C([H])=C([H])C([H])=C(OC(=O)C3=C([H])C([H])=C(Br)C([H])=C3[H])C2=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C2=C1C([H])=C([H])N2[H]
[H]C1=C([H])C([H])=C(O1)C1=NC(=C(O1)SC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N1C([H])=C(N2C([H])=C(Cl)C(Cl)=C2C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC2=C(SC3=C([H])N=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C23)C(=O)N1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(Br)=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C12
[H]OC(=O)C([H])([H])C([H])([H])C1=C(SSC2=C(C3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])N([H])C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C#CC1=C([H])\C(=N\OC([H])([H])[H])[C@]([H])(F)C([H])([H])C1([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)O[C@]([H])(C([H])([H])N1N=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(Br)N=C1[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)[P@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=N2)C([H])=C1[H]
[H]N1N=NC(=N1)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H]
[H]OC(=O)[C@]1(N([H])C(=O)C2=NN(C(=C2[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C2=C3C([H])=C([H])C(Cl)=C([H])C3=NC([H])=C2[H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]1([H])C3([H])[H])C2([H])[H]
[H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)C(=C(/C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)\C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O
[H]N(C([H])([H])C1=C([H])OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Br)C([H])=C([H])S1)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C(=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3OC(=C([H])C(=O)C3=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=NC([H])=C([H])C([H])=N2)C1([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])[C@]([H])(\C1=C(/[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N1C([H])=C([H])C(=O)C([H])=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C1=C([H])C2=C(N=C(O2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])N=C1[H]
[H]N([H])C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C2=C([H])C(O[C@@]([H])(C3=C(Cl)C([H])=C([H])C(F)=C3Cl)C([H])([H])[H])=C([H])C([H])=C2N=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C(=O)OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@]1(C#CC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(C([H])=C2N(C3=C(C([H])=C([H])C([H])=C3[H])C2=C1C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C2C3=C(C([H])=C(N=C3N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])N1C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1C(=O)C(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]C1=NC(O[C@]2([H])C([H])([H])C3([H])N([C@@]([H])(C([H])([H])C3([H])[H])C2([H])[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C(C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])=N1)C([H])([H])[H]
[H]C1=C(N=C(C(N2N=NC3=C2N=C(N=C3N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C3C([H])=C([H])C([H])=C([H])C3=C([H])C2=C1[H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(OC([H])([H])C1([H])[H])C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(F)=C1[H])C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C([H])C(=NC2=NC([H])=C([H])C([H])=C12)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C(F)C([H])=C2N3C(=NC(=C3C(=NC2=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
CC1=C(C=CC=C1)C1=CC=C(CCC(=O)N2CCC[C@H]2C2=NC=C(N2)C2=CC=CC=C2)C=C1
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])[H])[C@@]([H])(N2[H])C([H])([H])[H]
[H]C1=C(O[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C(OC2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1=NN(C(=O)[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])Br
[H]N(OC([H])([H])C(=O)OC([H])([H])[H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CNC1=NC(C)=C(S1)C1=C(C=NC(NC2=CC=CC(=C2)N2CCCN(CC2)C(C)=O)=N1)C#N
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=NC3=C(N2C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]ON=C1C([H])([H])C([H])([H])C(=C([H])[C@@]([H])(N(O[H])C([H])=O)C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C(=NC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NN(C(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C2=C1C([H])=C1C([H])=C([H])C(OC([H])([H])[H])=C([H])C1=N2
[H]N1C([H])=NC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC(N([H])C([H])([H])[H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C(Br)C([H])=C3[H])[C@]2([H])SC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(C(=O)[C@]23C([H])([H])[C@]4([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(C3([H])[H])C4([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=NN=NN1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]12C([H])([H])[C@]1([H])[C@@]([H])(N1C([H])=NC3=C(N=C([H])N=C13)N([H])[H])[C@]([H])(O[H])[C@]2([H])O[H]
[H]O\N=C1/C(=O)N(C2=C([H])C(=C([H])C([H])=C12)[N+]([O-])=O)C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H]
[H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N1C(=O)C2=NN(C(=O)N2C2=C1N=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]S\C(=N\C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H]
[H]C1=C(F)C([H])=C(F)C(SC2=C([H])N3C(=NN=C3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2Cl)=C1[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C(=C(C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(F)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]([H])(C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H]
[H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]1([H])OC1([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]OC(=O)[C@]1([H])[C@@]([H])(SC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])S1(=O)=O
[H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1[H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C([H])C4=NON=C4C([H])=C3[H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C(Cl)C([H])=C(C([H])=C1Cl)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@](C([H])([H])N([H])C1=C2C([H])=NN(C2=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C1([H])[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]C1=C(N=C(SC([H])([H])C2=NC3=C(C([H])=C([H])C([H])=C3C3=C([H])C(=NN23)C([H])([H])[H])C([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC(=O)C([H])([H])[H])=C(C([H])=C1Cl)[C@@]1([H])OC(=NN1C(=O)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(N=C(N2C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C([H])C(=C(C([H])=C3N3C(=NN=C3C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N1
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C4C(=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])S2(=O)=O)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])OC([H])([H])C([H])([H])[C@@](O[H])(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(C([H])=C4C(=O)OC([H])([H])C4=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C(Br)=C(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C(=O)C([H])([H])[C@]5([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]5(C([H])([H])[H])[C@@]4([H])C([H])([H])C(=O)[C@]23C([H])([H])[H])C([H])=C1[H]
[H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
COC1=CC(OC)=CC(CCC2=CC(NC3=NC(NCC4=CC(C)=NO4)=NC=C3)=NN2)=C1
[H]OC(C#CC1=C2N=C(N(C2=C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=N1)C([H])([H])C([H])([H])[H])C1=NON=C1N([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1I)C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=NC(=C(S1)C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1=C([H])C([H])=C([H])C(F)=C1[H])C(=O)N([H])[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C(N=C1C([H])([H])N([H])C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)S2)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C#C[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)C1=C([H])C2=C(OC(=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C2C(OC([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C#CC1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C(=O)O[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])SC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])S(=O)(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(N([H])C3=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C#CC2=C([H])C([H])=C3N=C([H])C4=C(N(C(=N4)C([H])([H])[H])C4=C([H])C([H])=C(C([H])=C4[H])[C@@]([H])(C#N)C([H])([H])[H])C3=C2[H])C([H])=N1
[H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NN=C(O4)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1O[H])C(=O)N([H])N([H])C1=C(C([H])=C(C([H])=C1[H])[N+]([O-])=O)[N+]([O-])=O
[H]C1=C([H])C2=C(O1)C(OC([H])([H])[H])=C(OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(OC([H])([H])[H])C3=C(C([H])=C([H])O3)C(OC([H])([H])[H])=C1C(=O)C([H])([H])[H])C(C(=O)C([H])([H])[H])=C2OC([H])([H])[H]
[H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1F
[H]N1C([H])([H])C([H])=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C(F)=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N1C(=O)N=C(C([H])=C1N(C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
COC1=CC=C(C[C@H](NC(=O)C(C)(C)N)C(=O)N2CC[C@H]2C2=NC3=C(N2)C=C(Cl)C(Cl)=C3)C=C1
[H]C1=C(C(N(C2=NC(=NC(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C2SC([H])=C([H])N2C1=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H])[C@]1([H])[C@]2([H])[C@@]3([H])[C@@]4([H])[C@]2([H])[C@]2(OC([H])([H])C([H])([H])O2)[C@]2([H])[C@@]4([H])C([H])([H])[C@@]3([H])[C@]12[H]
[H]OC(=O)C1=C(N=C(SC([H])([H])[H])N=C1SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])[C@]([H])(C([H])([H])F)C2([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(=C([H])C(Cl)=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])C([H])=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=NC(=O)C1=C(OC(=N1)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)C([H])([H])[H])N([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]N1C(=O)\C(=C(/[H])C(=O)C2=C([H])N=C([H])C([H])=C2OC([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C12
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C(=C(/[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C2=C1[H]
[H]N(C1=NC([H])=C2C(=C1[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C2C(=O)C([H])=C(N(C2=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N(N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=N\C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])\C(=O)C([H])([H])[H]
[H]N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C([H])N=C(N=C23)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C2=C(F)C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])SC3=NC(=C([H])N23)C2=C([H])C([H])=C([H])C([H])=C2N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])C([H])([H])SC2=NN=C(O2)C2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]C1=C(N2C(=N1)C([H])=C(N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=NC(Br)=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=C([H])C(=O)N([H])C2=S)[C@]1([H])N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H]
[H]OC(=O)C([H])([H])OC1=C2C(C(=O)C(=O)N([H])[H])=C(N(C2=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])[C@]2(SC([H])([H])C([H])([H])S2)C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(SC3=C(C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C2[H])[N+]([O-])=O)C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(C2=C(N=C1C([H])([H])[H])C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C(=NC2=C1N([H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C(=NC([H])=C2[H])N2C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(OC(=O)[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])=C([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(OC([H])([H])[H])=C(N([H])C3=NN4C(=C([H])C(Cl)=C4C([H])=N3)C3=C([H])C([H])=C([H])C([H])=C3N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N([H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]O[C@@](C#CC1=C([H])C([H])=C(C#N)C([H])=C1C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[C@@]1(C(=O)OC([H])([H])[H])[C@]2([H])\C(=C(\[H])C([H])([H])[H])C([H])([H])N3[C@@]4([H])O[C@@]5(N(C6=C(C([H])=C(OC([H])([H])[H])C([H])=C6[H])[C@@]15C4([H])[H])C([H])([H])[H])[C@]3([H])C2([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N(C(=O)C(N([H])C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)N([H])C4=C3C([H])=C([H])C([H])=N4)C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC(C3=C([H])N=C(N3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(F)C([H])=N2)C([H])=C1F)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C([H])=N2)C(F)(F)F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])[N@]2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]O\C(OC([H])([H])[H])=C1/N(C2=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C(N=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C(=O)N([H])[C@]2([H])C([H])([H])C([H])([H])C3=C(C([H])=C([H])C(F)=C3[H])[C@@]2([H])C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C(=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C(=N1)C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])N1C(=O)[C@]([H])(N(C([H])([H])C(=O)OC([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C(Cl)C([H])=C([H])C3=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(F)F)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=C(N=C(C#N)C(=N1)N([H])[C@@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]ON(C([H])=O)[C@@](C([H])([H])[H])(C([H])([H])[C@@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=C([H])N2C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C([H])([H])C#N)C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C(Br)=C2[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C2C([H])=NN(C2=NC([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])OC1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)N([H])C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])N2C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H])C1=NN([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])=O)C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C2=C(N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(N=C2[N+]([O-])=O)C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
ClC1=C(C[C@@H](NC(=O)N2CCC(CC2)N2CC3=C(NC2=O)C=CC=C3)C(=O)N2CCC(CC2)N2CCCCC2)C=C2OC(=O)NC2=C1
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C(SC([H])([H])[H])=NN2N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C#CC([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]([H])(N=C(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H]
[H]ON(C([H])=O)[C@@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1\C([H])=C(/[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C([H])C([H])=C23)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=S)OC2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C(=N/C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])\C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]ON([H])C(=O)C1=C([H])C(Br)=C([H])C(=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N1C(=NN=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H]
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
[H]C1=C(N(C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]O[C@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]1([H])C2=C([H])C(=O)C(N([H])C([H])([H])[H])=C([H])C([H])=C2C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C4C(ON=C4C([H])([H])[H])=C3C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C#N)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C(=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
CC1=CC(C)=C2C=C3C=CC(CCC(=O)NCCCCCC(=O)NCCCCNC(=O)OCCCN4C5=NC=NC(N)=C5C(=C4C(=O)CF)C4=CC=C(C)C=C4)=[N+]3[B-](F)(F)C12
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(C#N)=C(SC2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OS(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F
[H]C1=C([H])C([H])=C2O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N4C(=O)N(C5=C(C([H])=C([H])C([H])=C5C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])OC2=C1[H]
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])C(=C(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H]
[H]OC(=O)C1=C(N([H])C(=N1)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C(Br)C([H])=C2[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])[H]
C[C@H]1CN(C[C@@H](C)N1CC1=CN2C=C(N=C(N3CCOCC3)C2=N1)C1=CN=C(N)N=C1)S(C)(=O)=O
[H]C1=C(N(C(=C1C(=O)C([H])([H])SC1=NN=C(N1C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(Cl)C([H])=C2N2C1=NN=C2C(F)(F)F)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C([H])C([H])=C(O1)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(F)C(O[H])=C1[H]
C(N1C2=C(CCCCC2)C2=C1C=CC=C2)C1=CC=C(CN2C3=C(CCCCC3)C3=C2C=CC=C3)C=C1
[H]C1=C([H])C([H])=C(S1)C1=NOC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N2[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C([H])=C2O[C@]([H])(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])SC1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C(=C(C(=O)C([H])([H])[H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=NC3=C(N=C([H])N3[C@]3([H])O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]3([H])O[H])C(=N2)N([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC([H])=NC2=C1C(=C(Cl)N2C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(SC3=C2C2=C(C(=N3)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=N1
[H]N(C1=NC([H])=C2N(C(=O)N(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)C1(C2=NOC(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1C2=C(SC3=C2C([H])=C(Cl)C([H])=C3[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N3C(=O)C([H])([H])N(C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H]
[H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C#CC([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C(C2=NC([H])=C([H])C([H])=C2N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2/OC(=S)N(C2=O)C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])=C1Br
[H]C([H])=C([H])C([H])([H])N(C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=NC(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(SC([H])([H])C([H])([H])N([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C(N=N1)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(N([H])C(=N2)C2=C([H])C([H])=C(Cl)S2)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([C@]([H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(F)C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])OC([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C(=O)N(C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
[H]N1C(=O)N([H])C(=O)C(=C([H])C2=C([H])C([H])=C(O2)SC2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=O
[H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C(=O)[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC2=C([H])C([H])=C([H])C3=C2C(=C([H])N3[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(F)=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])O[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC([H])([H])[H])=NC([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C(N(C3=C([H])C(Cl)=C([H])C([H])=C23)C([H])([H])[H])C1=O)C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[C-]#[O+].[C-]#[O+].[C-]#[O+].NOOSC1=CC=C(CC[N@@]23CC(=O)O[Re]2[N]2=C(C3)C=CC=C2)C=C1
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C(Cl)=C1[H]
FC1=CC=CC(Cl)=C1CC1=C(C(=O)N2CCNCC2)C2=CC=CC=C2N1C1=CC=CC=C1
[H]N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=[N+]([O-])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C2=C(C(=NN2C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Br)=C(S1)C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O\N=C1\C(\N([H])C2=C([H])C([H])=C([H])C([H])=C\12)=C1\C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)O[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC([H])=NC2=C1C1=C(S2)C([H])([H])N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)O1
C[C@@H](O)[C@@H](C)OC1=C(Br)C=NC(NC2=CC=C(C=C2)S(=O)(CCO)=NS(=O)(=O)CC[Si](C)(C)C)=N1
[H]OC(=O)C(\[H])=C(\[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1O[H])[C@@]([H])(O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])N(N=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(S1)[C@]1([H])OC2=C(N=NC(SC([H])([H])C([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C(\[H])=N/OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
CN1CCN(CC2=C(C=C(NC(=O)C3=CC(C#CC4=CC5=C(NN=C5)N=C4)=C(Cl)C=C3)C=C2)C(F)(F)F)CC1
[H]N(C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C(C3=C4C([H])=C([H])N([H])C4=C([H])C([H])=C3OC([H])([H])C([H])([H])[H])=C(C([H])=C2C(=N1)N([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C(=C([H])C(Cl)=C1SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])OC1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C1C1=C3OC([H])([H])OC3=C([H])C3=C1[C@@]([H])(N(C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H]
[H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C(=O)C2=C([H])N=C(SC([H])([H])C([H])([H])[H])C([H])=N2)(C([H])([H])[H])C([H])([H])C([H])([H])S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)[N+]([O-])=O
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])N([H])C(=O)C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NSN=C1[H]
CN(C)CCOC1=CC=C(C=C1)C1=C(C2=C(NC[C@@H]3CC[C@H]3O)N=CN=C2N1)C1=CC=CC=C1
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NN(C1=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N(C3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C2=NC([H])=C([H])C([H])=C2N([H])C(=O)C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C#N
CC1(C)OB(OC1(C)C)C1=CC=C(N\C(S)=N\C2=CC=C(C=C2)S(N)(=O)=O)C=C1
[H][C@]12CC[C@]([H])(C[C@H](C1)OC1=CC=CC(=C1)C(N)=O)N2CC1=CC=CC=N1
[H]N([H])C(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=C([H])C2=C1C([H])=C([H])N=C2N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C(SC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC(=O)CC[C@H](NC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1)C(=O)OC
[H]OC(=O)C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(O3)(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N(N([H])C(=O)C1=C(OC([H])=C1[H])C([H])([H])[H])C(\[H])=C1\C(=O)N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C(=C(N([H])[H])C3=C2C(=O)C2=C([H])C([H])=C([H])C([H])=C2C3=O)S([O-])(=O)=O)C([H])=C1S([O-])(=O)=O
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C(C3=C2C([H])=C([H])C([H])=C3F)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
CCOC(=O)C1=CN(CC2=CC=C(OC)C(OO)=C2)C=C(C1C1=CC=CC(F)=C1)C(=O)OCC
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(N(C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=NN=C([H])N2[H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H])C([H])([H])[H]
[H]OC(=O)C(=C(/C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C1=C([H])C2=C(OC([H])([H])O2)C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C(=O)O[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC([H])([H])C([H])([H])O1
[H]C1=C([H])C(O[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C2=C1C1=C([H])C([H])=C(O[C@@]3([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1C2=O
[H]N(C1=NC([H])([H])C([H])([H])N([H])C(=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])C(=O)C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])N([C@]([H])(C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(O[C@]3(C(=O)N([H])C(=O)[C@@]([H])(N([H])[H])C3=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C1=C(OC([H])([H])C([H])([H])[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]\C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C(ON(\C1=N\C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(SC2=C([H])N=C(S2)N([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])N=C12
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C3=C1N=C([H])C([H])=C3[H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C(C(=O)OC([H])([H])[H])=C(C2=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\[C@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C([H])C(Br)=C([H])C([H])=C2C([H])([H])C1=O
[H]N1C(=O)\C(=C(\[H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H][C@]1(CN(CCN1)C1=CC=C(C(=N1)C1=NNC2=C1C=CC=N2)C(F)(F)F)[C@](C)(O)C(C)C
CC1=C(CCOCCCO[N+]([O-])=O)C=C(N1C1=CC(F)=CC=C1)C1=CC=C(C=C1)S(C)(=O)=O
[H]C1=NC([H])=C(C([H])=C1[H])[C@]([H])(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C2C(SC3=C(C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])=C([H])N([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C2=C(SC([H])([H])C(=O)N2C([H])([H])[H])C([H])=C1[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])N1C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[C@]2([H])OC([H])([H])C([H])([H])C2([H])[H])N2N=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C(=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C(F)(F)F
[H]OC(=O)C1=C(SC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2N1C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])[N+]([H])=C([H])N1[H])C([H])([H])C1=C([H])[N+]([H])=C([H])N1[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])S(=O)(=O)C([H])([H])[H]
[H]O[C@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(SC2=C([H])C([H])=C(C([H])=C2[H])N(C(=O)C([H])([H])[H])C([H])([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]C1=NC2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C4=C(F)C([H])=C([H])C([H])=C4C([H])([H])C([H])([H])[C@@]23[H])C1([H])[H]
[H]N(C(=O)C([H])([H])N(C(=O)C(\[H])=C(/[H])C1=C([H])N(N=C1C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C(O[H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(N=NN2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=NN2C2=C([H])C([H])=C3C([H])=C(Cl)C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])[N+](=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
COC1=CC(OC)=C2C(=O)C=C(OC2=C1)C1=CC(OC)=C(OC)C(OC)=C1
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1(C([H])([H])S[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C([H])([H])C1=NC2=C([H])C(SC([H])([H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CCC1=NN2C(=C1)C(=CC=C2OC)C1=NN(CCCCOC2=CC=C(C=C2)C2=NNC(=O)CC2C)C(=O)CC1
CC[C@@H](CO)Nc1ncc(Cl)c(n1)-c1cc(C(=O)N[C@H](CO)c2ccccc2)n(C)c1
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])[N+]([O-])=O
[H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])=C([H])C2=C1C(=O)C([H])=C([H])C2=O)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(Br)=C2[H])C(Cl)=C1[H]
[H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CN(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CCCNC(=O)C1=NN=C(C=C1)N1CCC2(CC1)CCN(CC1=CC(=CC=C1)C(F)(F)F)C1=C(O2)C=CC=C1
[H]N(C1=NN([H])C([H])=C1[H])C1=C(N2N=C([H])C([H])=C([H])C2=N1)C1=NC(=NC(N([H])C2=C([H])N(N=C2[H])[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C([H])([H])[H]
[H]O[C@](C1=C([H])C2=C([H])C(Cl)=C(C([H])=C2N1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1(C2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2N=C(N([H])C2=NC([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1OC([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])N(C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C(=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=C(N=C(N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C([H])C([H])=C([H])N=C23)C([H])([H])C1([H])[H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2([H])N(C(=O)C([H])([H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])N=C(C([H])=N1)N1C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@]2(N(C(=O)N(C2=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(O[H])C(=O)O[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]C1=C2C([H])([H])C([H])([H])[C@@]3([H])C(=C([H])C([H])([H])[C@@]4(C(=O)C([H])([H])C([H])([H])[C@]34[H])C([H])([H])[H])[C@@]2(C([H])([H])C([H])([H])SC([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C1=O
[H]C1=NC([H])=C2N1[C@]([H])(C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C2([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]O[C@]1(C([H])([H])N([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])S[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N(C1=C([H])C(=C(C([H])=N1)N(C(=O)C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])O[H]
CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1
[H]C1=C([H])N(C([H])=N1)C([H])([H])[C@@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1=C(C(=O)OC1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C1[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])N1C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1N=C([H])C(=N1)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C(Cl)C([H])=C(\C([H])=C2/S\C(=N/C([H])(C([H])([H])[H])C([H])([H])[H])N(C2=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C(=O)OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])N=C2N([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]O[C@]1([H])C([H])([H])O[C@@]([H])(OC2=C([H])C([H])=C(C([H])=O)C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3C([H])([H])[C@@]12[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N2C3=NC4=C([H])C([H])=C([H])C([H])=C4N3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(Br)SC(C(=O)C([H])([H])Br)=C1Br
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=N1)C1=NC([H])=C([H])S1)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C(C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])C2=C([H])N=C([H])N2[H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])N=C(S1)C1=NN(C([H])=C1[H])C1=C2C(=NC([H])=C1[H])N(C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H]
[H]O[C@@](C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
NC1=NC(=CC=N1)N1C=CC2=C1C=C(C=C2)[N+]([O-])=O
[H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C(SC(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C2=C([H])C3=C([H])C(=C([H])C([H])=C3O2)C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N(N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C([H])([H])C1=O
[H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C(OP([O-])(=O)OC([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC2=C(OC3=NC(=NC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2S1
[H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=C(C([H])=C(C2=C1[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
NC1=NC(=CC=N1)N1C=C(C2=NNC=C2)C2=C1C=CN=C2
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@](C1=C([H])C([H])=C(C#N)C([H])=C1[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C(N=C([H])N3C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])=NC([H])=C2[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H]
[H]N=C(SC([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC(=N[H])N([H])[H])N([H])[H]
[H]N(C1=NC([H])=C([H])C2=C1C(=NC2([H])[H])C(=O)OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=NN([H])C(=C1[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
Cc1cccc(c1)C1CN(CC=C)CCc2c(Cl)c(O)c(O)cc12
[H]N([C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])N2N=C(OC2=S)C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C(O[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C(N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C(O3)C([H])([H])O[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]ON1C([H])=C([H])C(=NC1=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])[N@+]1(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2([H])C3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C2=C(C3=C1C1(C([H])([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])N([H])C3=O)C([H])([H])C1=C([H])N=C(C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C(=O)[C@]([H])(C1=NN(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C(=NC2=C([H])C([H])=C(Cl)C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3F)C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N1C2=NC3=C(N2C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N(C(=O)C(\[H])=C(/[H])C([H])([H])C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=NN([H])C3=C2C(=NC([H])=N3)N([H])C2=C([H])C([H])=C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N([H])C([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])[C@]2([H])O[C@]([H])(O[C@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C2O[C@@]([H])(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C(=O)C([H])([H])[H])C(O[H])=C1C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C(C([H])=C(S2)C2=C([H])C([H])=NC([H])=C2[H])C1=O)C1=C([H])N=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C(=O)N([H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC([H])=NC2=C1N=C([H])N2[C@]1([H])O[C@]([H])(C([H])([H])N([H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])[C@@]2([H])O[C@@]([H])(O[C@@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC1=C([H])C(OC([H])([H])C([H])([H])[H])=C2C(=O)C([H])=C(OC2=C1[H])C1=C([H])C([H])=C(O[H])C(O[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C#CC#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1O[H])C(=N[H])N([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=NC([H])=N2)N2C(=NC3=C2C([H])=C([H])C([H])=C3[H])N([H])C2=C([H])C(N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H]
[H]C([H])=C([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])O\N=C(/[H])C([H])([H])[H]
[H]N(C(=O)[C@]1(C([H])([H])C([H])([H])[C@@]([H])(N([H])[C@@]2([H])C3=C(OC([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C(=O)N([H])\N=C(/[H])C1=C([H])OC([H])=C1[H]
[H]N1C(=NC2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])[C@@]1([H])SC(=O)N([H])C1=O
[H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(F)C(Cl)=C2[H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C1=NC(=NS1)C1=C([H])C([H])=C([H])N=C1[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C([H])N=C12)S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2(SC([H])([H])C([H])([H])S2)C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(F)C([H])([H])[H])C(C#N)(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
OC(C1=CN=C(S1)S(=O)(=O)C1=CC=C(C=C1)C(F)(F)F)(C(F)(F)F)C(F)(F)F
[H]C1=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C2OC(=C([H])C(=O)C2=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C3N(C(=NC3=C([H])N=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C([H])C(=N2)N2C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])O[C@@]([H])(N2C([H])=C(C3=C(N=C([H])N=C23)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])O[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=NN(C2=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)N([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H]
[H]N(C1=NC(C2=C([H])C([H])=C([H])O2)=C(S1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])OC1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC1=C([H])C(I)=C(C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])C(=O)C([H])([H])C([H])([H])[C@]4(O[H])[C@@]3([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]4([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C(C#N)=C(N1C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
O=C(NC1=CC=CC=C1)NC1(CCC1)C1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1
[H]C1=C([H])C(=C([H])C2=C1OC([H])([H])C([H])([H])O2)C1=NN=C(O1)SC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]N([H])C1=C2N=C(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])N([H])C2=NC([H])=N1
[H]OC1(C([H])([H])C([H])([H])C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H]
[H]C1=NN=C(SC([H])([H])C(=O)N2C3=C(C([H])=C(C([H])=C3[H])C([H])([H])[H])C3=C(SSC3=S)C2(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(=C([H])C(Br)=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])S1
[H]N(C1=C2N=C([H])C([H])=C([H])C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C1([H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N1C(=S)N(C(=O)C2=C([H])C([H])=C([H])C(Cl)=C12)C1=C(F)C([H])=C([H])C([H])=C1F
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(\C(=N\C(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])C1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC([H])=NC([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H]
[H]N(C(=O)C1(C(=O)N([H])C2=C([H])C([H])([H])[C@]([H])(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H]
[H]OC1=C(Br)C([H])=C(Br)C([H])=C1\C([H])=N\N([H])C1=NC(=O)C([H])([H])S1
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N([H])C1=C(Br)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]O[C@@]([H])(C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C2N=C(N=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(C2=C(C([H])=C([H])C(=N2)C([H])([H])C([H])([H])C([H])=C([H])[H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
COC1=CC=C(\C=N\NC2=NC3=C(N=CN3[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)C=C1Cl
[H]O[C@]1([H])C([H])([H])OC2=C(Cl)C([H])=C([H])C(N([H])C3=NC([H])=NC(=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C2C1([H])[H]
[H]ON(C(=O)N([H])C([H])([H])C1=NC([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2=O
[H]C1=C(N2C([H])=C([H])C(C3=C([H])C4=C(C([H])=C3[H])N(C([H])=C4[H])C([H])([H])[H])=C(C#N)C2=N1)C([H])([H])C(F)(F)F
[H]SC([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NN1S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1F)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])N2C([H])([H])C3=C(C([H])=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]C1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])N1C(=O)N(C(=O)C2=C1C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1(C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2(C3=C([H])C([H])=C4[C@]5([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]5(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NS2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=O)N(C2=C([H])C([H])=C(C([H])=C12)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC3=NC4=C([H])C([H])=C([H])C([H])=C4S3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]C1=C(N=C2N1C([H])=C([H])C([H])=C2OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(N=C(OC([H])([H])[H])N=C1OC([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])OC(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@@]3([H])C4=C([H])C([H])=C([H])[N+]([O-])=C4C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=NN2C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C12)C([H])([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(N([H])C(=C3[H])C3=C([H])C([H])=C([H])C4=C3C(=O)N([H])C4([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1N=C([H])C(N([H])C2=NC([H])=C(Cl)C(=N2)N([H])[C@]2([H])[C@@]3([H])C([H])=C([H])[C@]([H])(C3([H])[H])[C@]2([H])C(=O)N([H])[H])=C1[H]
[H]N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])=C([H])C(OC2=C([H])C3=C(C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C3([H])[H])=N1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H]
[H]N1N=C(C(=O)OC([H])([H])C(=O)C2=C(N(C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N([H])C1=C([H])C(OS(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=NC(SC([H])([H])C([H])([H])N([H])[H])=N1
[H]OC1=NSC(N([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1C#N
[H]N1C2=C(C([H])=C(S2)C(C(=O)N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C2C([H])=NC3=C([H])C([H])=C([H])C([H])=C3C2=NN1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])N1C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN=NN1[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C2N=C(C([H])=C([H])C2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N([H])C(=O)C1=C([H])C2=C(OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])=C([H])[H])C([H])=NC([H])=C2S1
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])O1)C(=O)C1=C([H])C([H])=C(O1)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C([H])O1
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])C2=NC([H])=C([H])C([H])=C12)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])=C1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])SC2=C(F)C([H])=C([H])C([H])=C2[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=NC(=C([H])C(=C2N=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2N([H])[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])[H])C(=C2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC(=C(O[H])N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C(=C2C(=O)O1)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1N([H])C1=C(N([H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C(F)=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C([H])C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1
CC1=C(Cl)C(C)=C2C(N)=C(SC2=N1)C(=O)NC(C)(C)C
[H]N1C(=O)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]13[C@]([H])(N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@]21[H])[C@@]3([H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]ON([H])C(=O)C1=C([H])N=C(N=C1[H])N([H])C1=NN=C(O1)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]C1=C(C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(N2C([H])=NC(=C2[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C2(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C(=O)[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C([H])([H])[C@@]13[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(=O)N([H])C2=C([H])C([H])=C([H])C(N([H])C3=C([H])C4=C(C([H])=C3[H])\C(=C(/[H])C3=C([H])C([H])=C([H])N3[H])C(=O)N4[H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])S2(=O)=O
[H]N([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C(=C([H])N3[H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])N([H])[H])C2=C1[H]
[H]C1=C([H])N(C(=C1[H])C([H])([H])N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])=C(C([H])=C2C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]23N(C(=O)[C@]([H])(N([H])C1=O)C2([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N1N=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]N1C(=O)\C(=C(/[H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C12
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OS(=O)(=O)N([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])OC(=O)N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2S1
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(N(C(SC([H])([H])[H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]\C(=C(/C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=NN=NN1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2C([H])([H])[C@]([H])(O[H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C(=O)O[H]
[H]N1N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=O
[H]O[C@@](C#CC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC(=NC([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(OC3=C([H])C([H])=C([H])C([H])=C23)C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C(=C([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])SC(=N1)C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C1=NN=C(C2=C1C([H])=C(N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C(Cl)C([H])=C3C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(OC([H])([H])[H])C(C(=O)N([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C(Br)C([H])=C1[H]
[H]N([H])C(=O)C1=C(C(=NC2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC(=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC2=C([H])C([H])=C(OC3=NC4=C(N=C3[H])N=C(N(C4=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2S1
[H]OC(=O)C1=C([H])C2=C(C([H])([H])[C@@]3([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2=NC([H])=C([H])C(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C(C(=O)N([H])C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])([H])N(C(=O)C([H])(C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2OC3=C(N=C(N([H])C3=O)C3=C(Cl)C([H])=C([H])C([H])=C3[H])C2=C1[H]
[H]N(C1=NC(=C(S1)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C(=C2N1C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(N1C([H])([H])C([H])([H])C(OC([H])([H])C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])OC(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(=N[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H]
[H]ON([H])C(=O)[C@@]1([H])OC([H])([H])C(=O)N([H])C2=C(SC([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(N([H])[H])=C(C([H])=C1C([H])([H])[H])S(=O)(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2OC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]N([H])[C@@]1([H])C(=O)N2[C@@]([H])(SC([H])([H])[C@@]2([H])C#N)C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])N2N=C([H])N=C2[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
COC1=CC=C2N(C(=O)C3=CC(=CC=C3)C(F)(F)F)C(C)=C(CC(O)=O)C2=C1
[H]N(C(=O)[C@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])SC1=NN([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(ON=C1C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C(Cl)=C(N([H])C([H])([H])C2=C([H])C(=O)OC3=C2C([H])=C([H])C(Cl)=C3[H])C([H])=C1[H]
[H]OC1=C(C([H])=C(Cl)C([H])=C1Cl)C(=O)N([H])C1=C([H])C([H])=C(SC2=NC3=C(S2)C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])C#N)C([H])([H])[C@]21[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C([H])N2[H]
[H]N(C(=O)N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=CC=CC(=C1)C1=CN(N=N1)C1=CC=C2OS(=O)(=O)C=CC2=C1
[H]OC(=O)[C@@]1(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C(=O)N1[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])N(C1=O)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C12
[H]N(C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=O)N1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C(=O)N([H])C(=O)N([H])C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]([H])(C(=O)C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(S1)C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C(OC([H])([H])[H])C([H])=C([H])N=C12)C1=NC(SC([H])([H])[H])=NC([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC(=NC(=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C2=NC([H])=NC(OC([H])([H])[H])=C2[H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]N(C(=O)N1OC(=O)C(=C1C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C(=O)N([H])C1=C([H])C2=C(N=C([H])N(C2=O)C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])N=C1[H]
[H]N(C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
OC(CNC1CCN(CC1)C1=NC=NC2=C1C(=CS2)C1=CC=CC=C1)COC1=CC=C(O)C=C1
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(\C(=N\N([H])C(=O)C([H])([H])C4=C([H])C5=C(OC([H])([H])C5([H])[H])C([H])=C4[H])C(=O)N3[H])C(Br)=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1Cl)C(F)(F)F)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C2=C(OS1(=O)=O)C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(O[H])=C1[H])[N+]([O-])=O
[H]N1C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C(S2)C([H])([H])OC([H])([H])\C([H])=C([H])\C([H])([H])OC([H])([H])C2=C([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(SC2=C3C(O[H])=NC(=NC3=C([H])C([H])=C2C([H])([H])[H])N([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N([H])C(=O)N([H])C1=C([H])C([H])=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H]
[H]N(C1=C2N=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])C1=C(N(N=C1C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C([H])C(Cl)=C([H])C([H])=C3Cl)C([H])=C2[H])=C1\C(=N\C([H])(C([H])([H])O[H])C([H])([H])O[H])N([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3N([H])C(=O)C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H]
COC1=CC=C(C[C@@H](C)N(CCCCCCNC2=C3C=CC=CC3=NC3=C2CCCC3)CC#C)C=C1
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(O[H])C(=C2O[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])[C@]([H])(N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(N([H])C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NC3=C([H])N=C([H])C([H])=C23)C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(OC([H])([H])[H])=NC([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C(=O)N([H])C([H])([H])[C@@]1([H])[S@@+](C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C(OC2=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])[H])=C([H])C([H])=C1[H]
[H][N+]([H])([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]SC1=NC2=C([H])C([H])=C(C([H])=C2C(O1)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(C#N)=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C(=S)N([H])N([H])C1=C2C([H])=C(F)C([H])=C([H])C2=NC1=O
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])C([H])=C([H])S1)C2(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])O[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C(=O)N(C2=NOC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2=C([H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])N=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=C2[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@@](OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)N1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(C#CC2=C([H])N=C3C([H])=C([H])C([H])=C([H])N23)=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N([H])C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
[H]N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])=C([H])C([H])=C2[H]
[H]O[C@@]([H])([C@@]([H])(OC([H])([H])C([H])=C([H])[H])C(=O)N([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C([H])=C([H])[H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H]
[H]N(C([H])([H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]12C([H])([H])C([H])([H])C(=O)[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]C1=C(C([H])([H])[H])C([H])([H])N(O1)C1([H])C([H])([H])C([H])([H])N(C(=O)N2OC(=O)C(=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])C([H])([H])[C@]1(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C([H])([H])[H])=C1[H]
[H]O[C@@](C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N([H])C1([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC(=C([H])C(=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])O1
[H]OC([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C2=NOC(=N2)C([H])([H])N(C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
ONC(=O)CNS(=O)(=O)C1=CC=C(OCC2=CC=CC=C2)C=C1
[H]ON(C(=S)N([H])C([H])([H])[H])[C@]([H])(C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])N([H])C(=O)C2=C3C(N([H])C4=C3C([H])=C([H])C([H])=C4[H])=C3N([H])C4=C(C([H])=C([H])C([H])=C4[H])C3=C12
[H]N(C1=NC(=NC2=C1N(C(=O)N2C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C([H])C(Cl)=C2C(O[H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C(=C2OC([H])([H])C(=O)N([H])C2=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C#N)C(=C1[H])S(=O)(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])[C@@]([H])([N@@]2C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C(=C(OC([H])([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(C(=N/OC([H])([H])C([H])([H])[H])\C4=C([H])C([H])=C(Br)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
CC1=NC2=CC=CC(N3CCN(CCC4=C5OCC6=C(N=CN6C5=CC=C4)C(N)=O)CC3)=C2C=C1
[H]OC(=O)C1=NN2C(=N1)C(O[H])=NC1=C([H])C(=C([H])C([H])=C21)[N+]([O-])=O
[H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])Br)C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H]
[H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])[H]
[H]C1=C([H])[N+]([O-])=C([H])C(=C1[H])C(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C2=C(C([H])=C(Br)C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1N=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C4C(=O)N([H])C(=O)C4=C4C5=C(C([H])=C([H])C([H])=C5[H])N(C4=C23)C([H])([H])C([H])([H])[C@]1([H])O[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C(C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC([H])([H])C1(N([H])C(=O)[C@@](N([H])C(=O)O[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]2(C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])N(C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]N([H])C1=C(C([H])=NC2=C([H])C([H])=NN12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Br)C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(O1)C([H])=C([H])C(C#N)=C2[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N1[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(Br)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])SC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]C1=NC(=C([H])C(=C1C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(O[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C(SC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NC([H])=C2[H])=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])C(=O)C([H])([H])SC2=NC3=C(S2)N=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N(O1)C([H])([H])[H]
[H]C1=C([H])C2=C(N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[C@]3([H])OC4=C5C([H])=C([H])C(=NC5=C([H])C([H])=C4OC3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C([H])C(=C2[H])[N+]([O-])=O
[H]O[C@@](C(=O)N([H])C1=C([H])C([H])=C2C(=O)ON=C(C2=C1[H])C([H])([H])[H])(C([H])([H])[C@@]1(C2=C(C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1OC([H])([H])[H])C1=C([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=N1)C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C2=C1N=C([H])N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(O[H])N=C2C(=N1)C([H])=C(C([H])=[N+]2[O-])C(F)(F)F
[H]OC([H])([H])C(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=[N+]1[O-])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])O[H])C([H])([H])O[H]
[H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C23)=C1[H]
[H]C1=C(N(C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]OC1=NC(=NC2=C1C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])N(C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C#C[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C(N=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1=C(N=C2C([H])=C([H])C([H])=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H][C@]1(CCN(C1)C(=O)[C@@H](N)CC1=CC=C(O)C=C1)S(=O)(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
[H]N(C(=O)C([H])([H])SC1=NC(C2=C([H])C([H])=C([H])O2)=C(N=N1)C1=C([H])C([H])=C([H])O1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(N=N1)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N=C1N([H])C(=C([H])C(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C1C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(I)C([H])=C1[H])C(=O)O[H]
[H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(O[H])=C(\C([H])=C(/[H])C(=O)C2=C(O[H])C([H])=C(O[H])C([H])=C2OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NC2=C(C([H])=C1[H])C1=NC3=C([H])C([H])=C(F)C([H])=C3C(C([O-])=O)=C1C([H])([H])C2([H])[H]
[H]OC([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N(N=C1C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SC([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C2=NC([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(SC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(SC([H])([H])C3=C(C([H])=C(C(C(=O)C([H])([H])[H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])S2)C([H])=C1[H]
[H]N(C1=NC2=C(N=C(S2)C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C1=NN([C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2O[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[C@]2([H])O[C@]3([H])C([H])([H])[C@@]4([H])[C@]5([H])C([H])([H])[C@]([H])(F)C6=C([H])C(=O)C([H])=C([H])[C@]6(C([H])([H])[H])[C@@]5(F)[C@@]([H])(O[H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3(O2)C(=O)C([H])([H])O[H])C([H])=C1Cl
[H]N(\C(=N/C#N)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=NOC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@@]1(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N(C2=C3C(Cl)=C([H])N([H])C3=NC([H])=N2)C([H])([H])C1([H])[H]
CN(C1=C(C(=O)N2CCNCC2)C2=CC=CC=C2N1C1=CC=CC=C1)C1=CC=CC=C1
[H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])S1
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])\C(=N/[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])C2=C1C([H])=C(Cl)C([H])=C2[H]
[H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=NC([H])=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(C2=C([H])C([H])=C(S2)C#CC([H])([H])OC([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])OC2=C([H])C(N([H])C(=O)[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C([H])N=C1[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C([H])([H])[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C(=N1)C1=C([H])C([H])=C([H])O1
[H]N(C1=NC2=C(S1)N=C(N=C2N([H])C1=C([H])C([H])=C(C(Cl)=C1[H])C(F)(F)F)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C2=C(S1)C(=NC(=N2)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]N(C1=NC([H])=NC(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N=[N+]=[N-])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1N=C(OC1=S)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])[C@]1(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2(C(=C([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2/SC(=S)N(C2=O)C([H])([H])[H])C([H])=C1Br
[H]N([H])C(=O)C1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C(C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])=C([H])C([H])=N2)C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C([H])([H])C([H])([H])[H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C(C([H])=C([H])C(F)=C1[H])C(=O)N([H])C([H])([H])C1=NC2=C(S1)C(F)=C([H])C(F)=C2F
[H]N(C(=O)C1=C([H])C(=C(Cl)C([H])=C1Cl)S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NN=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=N2)N1C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC2=C(C([H])=C3C(=N2)C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C3([H])[H])C(=N1)N([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H]
[H]OS(=O)(=O)C([H])([H])C1=C(OC([H])([H])C(=O)N2C([H])([H])[C@@]([H])(N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Cl)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]O[C@]1([H])OC([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C([H])C2=C(SC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C(=C([H])C2=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H]
[H]C1=C(C(=O)OC([H])([H])[H])C(C(=O)OC([H])([H])[H])=C2N3C([H])=C([H])C([H])=C([H])C3=C(C(=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C(=O)\N=C1/SC(=C(N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C3=C([H])C(F)=C(F)C(F)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C3C([H])=C([H])N(C3=NC([H])=N2)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N=C(SC([H])([H])C([H])([H])C([H])([H])OC1=C(Cl)C2=C(C([H])=C(N([H])[H])C([H])=C2[H])C(=O)O1)N([H])[H]
[H]N(C1=C([H])C(Cl)=C([H])C(Cl)=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)N2C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])C2=NC([H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=C1[H])C(=C([H])C(=N2)C(F)(F)F)C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])[C@]3([H])N(C(=O)C([H])([H])[H])[C@]([H])(C2([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@](C1=C([H])C2=C([H])C(Cl)=C(C([H])=C2N1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])SC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])N2C([H])([H])C(F)(F)F)C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC(=O)\C(N1[H])=C1\C2=C(N([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC(=C(N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NC2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2S1
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2OC1([H])[H]
[H]OC(=O)C([H])(C(=O)O[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(N([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(Br)=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(Br)=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C(=O)C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C([H])C([H])=C3O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O2
FC(F)(F)C1=CC=CC(CN2CCC3(CCN(CC3)C3=NC=C(C=C3)C(=O)NCCC3CC3)OC3=C2C=CC=C3)=C1
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C(F)C(F)=C([H])C(F)=C2F)C(Br)=C1[H]