[H]OC(=O)C([H])([H])N(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=NN1C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C(=C([H])N3[H])C(=O)N([H])C([H])([H])C([H])([H])C3=C([H])N=C([H])N3[H])C2=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])OC3=C([H])C4=C(N([H])C([H])=C4C([H])([H])C([H])([H])N([H])[H])C([H])=C3[H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] ON(=O)C1=CC=C(NC(CC(=O)C2=CC=CC(Cl)=C2)C2=CC(F)=CC=C2)C=C1 [H]N(C(=O)C1=C2OC([H])([H])C([H])([H])C2=C([H])C(Br)=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C(=C([H])C([H])=C1[H])N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N=C1[H])N([H])C(=O)C1=C([H])C(=NN1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]N(\C([H])=C(\[H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Br [H]ON(C(=O)N([H])C([H])([H])C1=NC([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])C(=C([H])C(=N1)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])[C@]([H])(C(=O)O[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OS(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F [H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC([H])=N2)C([H])([H])C1([H])[H] COC1=CC(CNC(=O)N(CCO)C2=CC=C(C=C2)C2=CNN=C2)=CC=C1 [H]O[C@]([H])(C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])=NC([H])=C2[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C2=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H] [H]N([H])C1=N[C@]([H])(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2N=C1OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON(C(=O)N([H])[H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H] [H]N(C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] NC(=O)C(=O)N1CCC2=C(C1)C(=NN2CCCN1CCN(CC1)C1=CC=CC=C1)C1=CC(C#CC2=CC=C(CNCC3=CC=C(Cl)C=C3)C=C2)=C(Cl)C=C1 [H]N(C1=NC2=C([H])C([H])=C(C([H])=C2N2C([H])=NC([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] ON(=O)C1=CC=C(CNCCCC(=O)N2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)C=C1 [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NOC(=N1)C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#N [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC(=O)N2C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C2([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] CC1=C(Cl)C=CC=C1C(=O)N1CCC[C@@H](C1)C1=NC(=NO1)C1=CC=C(F)C=C1 [H]N(C([H])=O)C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1N2[H] [H]N(C(=O)C1=C([H])N([H])C(=O)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C2C(OC([H])([H])[C@@]([H])(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C2([H])[H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])N(N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C(F)=C(C(Cl)=C1[H])C([H])([H])OC(=O)N(C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])[C@]2(C2=C([H])SC([H])=C2[H])C1([H])[H] [H]OP(=O)(O[H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])S1)S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C(=C1C(=O)N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=N3)C([H])=C([H])C([H])=C2[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])SC(=N1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C(C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(Br)C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C(=S)N([H])C([H])([H])[C@@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N([H])\C(=C(\[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])C1=O [H]N1N=C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=NC(=NO1)C([H])([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H])C([H])([H])N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=O)N2C3=C(C([H])=C(N=C13)C([H])([H])[H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C3=NC(=NC(N([H])[H])=C23)N([H])[H])C([H])=C1[H])C(=O)O[H] [H]N([H])C1=NC(N([H])[H])=C2C(OC([H])=C2C([H])([H])N([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=N1 [H]OC(=O)C([H])([H])SC1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O [H]N(C(=O)[C@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C(=C2C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(S1)C([H])([H])[H] [H]N1C([H])=NC(=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=NC(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=S)N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [Br-].CN(C)C1=CC=C(C=C1)C1=C2C=CC(C=C2[Se]C2=C3CCCN4CCCC(C=C12)=C34)=[N+](C)C [H]OC1=C(O[H])N=C2C(=N1)C([H])=C(C1=C2C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[N+]([O-])=O [H]N1C(=O)N(C2=C(N(C(=N2)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]OC1=NC(=NC2=C1N=C(C([H])([H])C1=C([H])C([H])=C([H])O1)C2([H])[H])N([H])[H] [H]C1=C([H])C([H])=C2C(=N1)N=C(N(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C2=O)[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N(N=C1C([H])([H])[H])C1=NC(=NC(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/C(=O)N=C2SC(=NN2C1=N[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])C3=C([H])C([H])=C([H])C(=C3[C@@]([H])(C([H])([H])[H])[C@]2([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(C3=NSC(=N3)C3=C([H])C([H])=C(C(C#N)=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON(C(=O)N([H])[H])[C@@]1([H])C2=C(C3=C([H])C(=C([H])C([H])=C3N2C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])OC2=C([H])C([H])=C(C([H])=C2O1)C([H])([H])N([H])C(=O)[C@]1([H])SC([H])([H])C([H])([H])N1C(=O)C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H] CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=C(C)C=C2)C=C1 [H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(C(F)=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H] [H]C1=C2SC3=C([H])C([H])=C([H])C([H])=C3C(=C([H])N2C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C([H])C(=C1C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C3=C(C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C3([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])\C(=N\C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\N=C1/N3C(=NC4=C1C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])N1C(=N2)C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NN2[H])C2=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C3C(=N2)N([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H][C@@]12CC3=CN(C)C4=CC=CC(=C34)[C@@]1([H])C[C@H](CN2C)C(=O)N(CCCN(C)C)C(=O)NCC [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(\N=C(/[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])C2(C3=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O\N=C1/C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])=C([H])C([H])=C2C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C2=C([H])C(=C([H])C([H])=C2C([H])([H])C([H])([H])C1=O)C([H])([H])O[C@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=NC([H])=C1[H] [H]N=C1N2N=C(SC2=NC(=O)\C1=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC(=O)C2=C([H])C([H])=C([H])O2)C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C2=NC(=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H] [H]N(C(=O)N([H])C1=C(OC(F)(F)F)C([H])=C(C([H])=C1[H])C1=NN([H])N=N1)C(=O)C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C([H])=C([H])C(=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=S)N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C([H])N(C3=NC([H])=C([H])S3)C2=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C1([H])[H])C2=O [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(N=C3C([H])=C(N=C(N23)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C([H])=C([H])C(=N1)C#CC1=C([H])C2=C(SC([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@]1(C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])[C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C2N=C(N=C2N1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(C1=NN=NN1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C1C1=C([H])C([H])=C([H])C3=C1C(=O)N([H])C3([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C2=C([H])N=C(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])N([H])[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]N(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[N+]2=C(C([H])=C(C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H])C([H])([H])F [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])C2=NC3=C(N=C(N=C3N=C2[H])N([H])[H])N([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)O[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2C(C(=O)C([H])([H])C([H])([H])C2=C([H])C(F)=C(F)C([H])=C2[H])=C1C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C2C(=N1)C([H])=C([H])C(Cl)=C2N([H])C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(N([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@]([H])(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C([H])([H])F)C([H])([H])C2=C([H])C([H])=C([H])C3=C2OC([H])([H])O3)C([H])=C1[H] [H]OC(=O)[C@]1([H])[C@@]([H])(SC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C(=O)N([H])C(C1=O)(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C([H])=C(OP([O-])(=O)OC([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H][C@@]1(CCCCN1CC=C)[C@H](C(=O)OC)C1=CC=CC=C1 [H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3Br)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C2N=C(N(C2=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C([H])([H])C1=C(C(=C([H])N=C1[H])C1=C([H])N=C2N([H])N=C(C3=NC4=C(N3[H])C([H])=C([H])C([H])=C4C([H])([H])OC([H])([H])[H])C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)C([H])([H])[C@]([H])(C2=C(C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C(C([H])=NC([H])=C2S1)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NN=C(N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(N=C([H])C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C(N2C([H])=C([H])C([H])=C2[H])N(N=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C(\[H])=C(/C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] FC1=CC=C(C(=O)N2CCN(CC2)C2=NN=C(C=C2)C(=O)NCCC2CC2)C(=C1)C(F)(F)F [H]N1C([H])=C([H])C2=C(N=C([H])N=C12)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]N(C(=O)C([H])([H])SC([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2C(=NC([H])=C1[H])N([H])C([H])=C2C1=NC([H])=NC([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=NN2[H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(=C3[H])C3=C([H])C([H])=NN3[H])C2=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(N=C1C(F)(F)F)C(=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2N([H])C(=N3)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]ON(C(=O)N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[P@@](F)(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H] [H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=NOC(=C1C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4[H])C([H])=C([H])C(Cl)=C5[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])=C([H])C([H])=C(C2=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=NN=NN1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=N1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(N=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1C(=NC2=C1C([H])=C(F)C(F)=C2[H])N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])N1C([H])([H])C2=C(SC([H])([H])[H])C3=C(C([H])=C(Cl)C([H])=C3[H])N2C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=N\OC([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C([N+]([O-])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[C@]1([H])N1C(=O)OC([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C(\[H])=C(\[H])C([H])([H])[H] O=C(NC1CCN(CCCN2C(=O)COC3=C2C=CC=C3)CC1)C1CCCC1 [H]C1=C([H])C2=C(OC(=O)C([H])=C2C(F)(F)F)C(=C1OC([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O [H]N(C(=O)C1=NC(N([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])(OC3=C(C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C2=C([H])C([H])=C(N([H])C(=O)C3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N([H])C2=C(C([H])=C(F)C(N([H])C([H])([H])[H])=C2[H])C1=O [H]C1=NC([H])=C([H])C(=C1[H])C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])[C@@]1(O[H])C([H])([H])[H])C([H])([H])OC(=S)N([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] O=C(NC1=CC=CC(NC2=NN=NN2)=C1)N(CCC(C1=CC=CC=C1)C1=CC=CC=C1)CCN1CCOCC1 [H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] COC1=CC(CN(CCN2CCCCC2)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1 [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]N(C1=NC([H])([H])C([H])([H])O1)C1=C(C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(C([H])([H])C([H])([H])C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC([H])([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N(C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C2=C(SC(=C2[H])[C@@]([H])(N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])S1 [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(SC([H])([H])[H])C([H])=C([H])N=C3N2C([H])([H])C([H])([H])C1([H])[H] CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CC=CC=C1OC [H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C([H])([H])C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C3F)C3=C([H])C(F)=C([H])C([H])=C3C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=N[C@](C2=C([H])C([H])=C([H])C(F)=C12)(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(N=C1OC([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1N=C(C2=C(N(N=C2C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(C1=C([H])N=C(S1)N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]N([H])C1=NN2C([H])=C([H])C([H])=NC2=C1C1=NC([H])=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H] [H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])N=C2[H])C(=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])[C@]([H])(O[H])C([H])([H])[C@]4([H])C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C5=C([H])C(=C([H])C([H])=C5[H])C([H])([H])N(C5=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C5C([H])([H])[H])C([H])([H])C5=C([H])C([H])=C(OC6=C([H])C([H])=C([H])C([H])=C6[H])C([H])=C5[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])[C@]([H])(O[H])[C@]12C([H])([H])[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(F)=C2O\C1=C(\[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])O[H])C([H])=C1[H])C(=O)O[H] [H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(SC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])OC([H])([H])C([H])([H])N([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=O)N([H])C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C3=C(N=C(N=C3[H])C#N)N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])[C@]([H])(C1([H])[H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C(N([H])C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)N1C(=NC(C2=NN=C(S2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] ClC1=CC=C(C=C1)C1=C[N-]C(=N1)[C@@H]1CC2=CC=CC=[C]2=CN1 [H]N1N=C2N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C1=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C(F)C(Cl)=C(F)C([H])=C3[H])C2=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C2=C(S1)C(=O)C([H])([H])C([H])([H])S2(=O)=O [H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC1=C2\C(=C(\[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C1=C2C(=C([H])C(=C1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=NC3=C(N2[H])N(C(=O)N(C3=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(F)=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])N([H])C2([H])[H])C(F)=C1[H] [H]ON([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2OC1=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\N=C(/SC([H])([H])[H])N([H])C#N)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])[C@]([H])(O[H])[C@]([H])(OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(\[H])C([H])([H])O[H])C([H])=C1[H])C([H])([H])O[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([C@]1([H])ON=C(C(=O)N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])(C(F)(F)F)C(F)(F)F [H]C1=C([H])C(C(=O)C2=C([H])C([H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C(C([H])=C2N2C([H])=NC([H])=C12)N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)N1C(=O)[C@]2([H])C([H])([H])N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C([H])C([H])=C3[H])[S@](=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C2=NN=C(O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C(N=C1[H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])C([H])([H])[H] [H]N1N=NC(=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1=C([H])C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=NC([H])=C([H])S1 [H]N(C(=O)[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C2C(OC3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]OC1=C(N([H])C2=N[S@](=O)N=C2N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=NC2=C1SC1=C2C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N(C1=NC(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2SC([H])=C(C2=C1[H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])C(=O)OC([H])([H])[C@]2([H])N(C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C2([H])[H])=C([H])C([H])=C1Cl [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])SC1=NN=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(Cl)C([H])=C(OC([H])([H])[H])C(=C1[H])C1=NC(=NN1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N=C([H])C([H])=N2)C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 COC1=C(OC)C=C(OCC2=CC(O[C@@H]3CCN(C)C3)=C(Cl)C=C2)C(Br)=C1 [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C22C([H])([H])C3(OC12C([H])([H])C3([H])[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])C(Cl)=C1[H])[C@]1([H])O[C@@]2(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N2C(=O)N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C2C(=NN(C(=O)C2=C1[H])C([H])([H])[H])C1=C(C(=O)C2=C(O1)C([H])=C([H])C(F)=C2[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])C(=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)C(F)(F)F)=C2C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C1=C([H])C([H])=C([H])C(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4[H])C([H])=C([H])C(=C5[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=C([H])C(=C2[H])C([H])([H])[H])C(=O)OC([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(=N\O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C(Cl)=C1C1=C([H])C([H])=C(O1)C(=C1/N=C([H])C([H])=C1[H])\C([H])([H])[H] [H]OC1=C([H])C(O[H])=C2C([H])=C(SC2=C1[H])C1=C([H])C([H])=C(O[H])C(F)=C1[H] [H]N1C([H])=NC2=C1N([H])C(=O)N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1OC(=O)C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C2=C([H])C(C#CC3=C([H])C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])=NC(=C2[H])C([H])([H])[H])C([H])([H])C1=O [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C(Cl)C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N(C4=C([H])C([H])=C(Cl)C([H])=C4[H])C4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C#N)C([H])=C1C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C1[H] [H]N1C(=C([H])C2=C1C([H])([H])[C@]([H])(N([H])C2=O)C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C2=C(C3=C(C([H])=C([H])C([H])=C3[H])C1=O)C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H] [H]N([H])C1(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)OC([H])([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)C1=C(O[H])C2=C(C([H])=C([H])C(=C2[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([3H])([3H])[3H])C([H])([H])C([H])([H])C1=C(OC([3H])([3H])[3H])C([H])=C(I)C(OC([H])([H])[H])=C1[H] [H]OC(=O)[C@@]12C([H])([H])C([H])([H])[C@@](C3=NC4=C(N3[H])N(C(=O)N(C4=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(C([H])=C4C(=O)OC([H])([H])C4=C3C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1([H])[H] [H]O[C@]([H])(C([H])([H])[H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C1=O)C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)O\N=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(SC1=NC(Cl)=C([H])C(=N1)N([H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])O1)C1=NC(=NC(=C1[H])C1=C([H])OC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@@]1([H])[C@]2([H])C([H])=C([H])[C@@]([H])(C2([H])[H])[C@@]1([H])N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C([H])N(N=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1\C([H])=C1/N([H])C(=O)N(C1=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C(C([H])=C2OC(=O)C([H])=C([H])C2=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@](OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C(C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C1[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N1C([H])([H])C([H])([H])C2=NN(C(=O)C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]OC(=O)C1=C([H])C(N([H])C(=O)C2=C(O[H])[C@]3([H])OC4=C(O[H])C([H])=C([H])C5=C4[C@@]33C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])[C@]([H])(C5([H])[H])[C@]3(O[H])C2([H])[H])=C([H])C([H])=C1[H] [H]C1=NC(OC2=C([H])C(Cl)=C([H])C([H])=C2Cl)=C(C([H])=N1)C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])SC1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] COC1=CC(Cl)=C(NC2=NC(=CN([C@@H](COCCF)C3CC3)C2=O)C#N)C(Cl)=C1 [H]N([H])C1=C(C(=NC(=N1)C([H])([H])[H])C#CC1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(O[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C([O-])=O)C1=C2C([H])=C([H])C(=[N+]([H])[H])C(=C2OC2=C(C(N([H])[H])=C([H])C([H])=C12)S([O-])(=O)=O)S([O-])(=O)=O [H]OC(=O)C(=C([H])[H])C([H])([H])N([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(\C([H])=C(/[H])C2=NC([H])=C([H])N=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=C(Cl)C([H])=C(OC([H])([H])C3=C(ON=C3C([H])([H])C([H])([H])C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H] [H]C1=C([H])N2C(=N1)C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])OC(=O)C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1=C(C(=O)OC([H])([H])[H])C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C(=NN1[H])C1=C([H])C2=C(S1)N1C(=NN=C1C([H])([H])N=C2C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N(C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=N1)C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]SC1=NN=C(S1)N([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])=C(N(C2=O)C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])N([H])N=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C1=NC(C#N)=C2N=C([H])N([H])C2=C1[H])C(F)(F)F [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(SC(=C1[H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H] [H]C1=C([H])C([H])=C(C#CC2=C(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=NC(=C2C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1N(C(=O)C(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C(C([H])=C([H])S1)C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1 [H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C([H])([H])O1 [H]N1C2=NN(C([H])=C2C(=NC2=C1C([H])=C([H])C(F)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(Cl)C([H])=C([H])C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C(C#CC#CC([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C2=NC(=C([H])C([H])=N2)C2=C([H])C(OC([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])N(C([H])([H])[H])C([H])([H])C3=C([H])C1=C([H])C([H])=C3OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=C([H])C([H])=C2[H] [H]N(C(=O)[C@]1([H])N(C([H])([H])[H])[C@]2([H])C3=NC4=C(C([H])=C(C(=C4[H])C([H])([H])[H])C([H])([H])[H])N3C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])N(C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=S)N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])C1=C(SC([H])=C1[H])C1=C([H])SC([H])=N1 [H]OC1=C2O[C@@]3([H])[C@]([H])(N(C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C([H])O4)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]O[C@@]([H])(C(=O)N([H])C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(=NC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(SN=C2C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H] [H]N1C2=C([H])C(=C([H])C([H])=C2C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=C1C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=S)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(Cl)C([H])=C(OC([H])([H])C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1Cl [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(C1([H])C([H])([H])C([H])([H])N(C2=C3N=C(N(C3=NC([H])=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC1=C2C([H])=C([H])C([H])=C([H])C2=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C2C(=NN1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])SC2([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(N=C(N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]C([H])=C(C([H])([H])[H])[C@@]1(SC(=NC1=O)N([H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C(S[C@@]3([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])N=C([H])O2)C(OC([H])([H])[H])=C1[H] [H]O[C@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(C(=O)C2(O1)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])S[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])[C@]1([H])O[H] [H]O[C@@]12[C@@]([H])(OC([H])([H])[H])[C@]3([H])[C@@]4([C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@]3(C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N1C(=O)[C@@]([H])(C([H])([H])[H])[C@@]([H])(C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@]4([H])OC([H])([H])[H])[C@]1([H])C([H])([H])[C@@]3([H])[C@]([H])(OC([H])([H])[H])[C@]1([H])[C@]2(O[H])C([H])([H])[C@]3([H])OC([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=N1)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C(=C(\C([H])=C(/[H])C2=C([H])C(=C([H])N=C2[H])C2=NN([H])N=N2)C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(SC3=C(C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])O1 [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C(=O)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]N1C2=C(N=C1[C@]13C([H])([H])[C@]4([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]([H])(C3([H])[H])C4([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C(=O)C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C1=C2N=C([H])C([H])=C([H])C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(Cl)S1)C([H])([H])O[C@]1([H])C2=C(S[C@]1([H])C([H])([H])N1C([H])=NC([H])=C1[H])C(Cl)=C([H])C(Cl)=C2[H] [H]OC(=O)C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F)C([H])([H])C(\[H])=C(/[H])C1=C(O[H])C([H])=C([H])C(=C1[H])C(=N[H])N([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C([H])=C(OC1=O)C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C(N=C=S)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])N2C(N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C#N)C#N)C([H])([H])C([H])([H])C1([H])[H] [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])Cl)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C([H])C(=N1)C([H])([H])SC1=C([H])C([H])=C([H])C(=C1[H])C(=O)O[H] [H]N(C(=O)C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C2N1C([H])=C(C([H])=C2C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])N1N=C(C(=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H] CCC1=C2NN=CC2=CC(CC(NC(=O)N2CCC(CC2)N2CC3=C(NC2=O)C=CC=C3)C(=O)N2CCC(CC2)N2CCCCC2)=C1 [H]N([H])C(=O)C1=C([H])C2=C(N=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[C@]3([H])OC4=C5C([H])=C([H])C(=NC5=C([H])C([H])=C4OC3([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])O[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N([C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([O-])=O)C([H])([H])[H])P([O-])(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C2=NC([H])=C([H])N2[H])C([H])([H])N(C1=O)C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N1C2=C(C(=C([H])N3C2=NC(=C3C([H])([H])[H])C([H])([H])[H])N2N=C([H])N=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]C1=C([H])C(Cl)=C(C(=O)OC([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])S2(=O)=O)C(Cl)=C1[H] [H]C([H])([H])C1=C(C(=O)ON1C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)N(C(=N2)C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]O[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=O)C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])SC(=N1)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1(C2=C([H])N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(N2C(=O)\C(=C(/[H])C3=NC([H])=C([H])C([H])=C3[H])[C@@]2([H])S(=O)(=O)C1([H])[H])C([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=NN=C(S2)C2=C([H])C(C#N)=C(C([H])=C2[H])C2=C([H])C([H])=C([H])S2)C(=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=NC([H])=C1[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N=C([H])C(Cl)=N2)C([H])=C1[H] [H]N1C([H])=C(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C4(SC3([H])[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(OC([H])([H])[C@@]4([H])OC4([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N1C(=O)C(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(C#N)N1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])O2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])C2=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=NC(=C([H])C([H])=C1Cl)N1C(=O)N2C3=C(C([H])=C(N=C13)C([H])([H])[H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C1=NN(C(O[H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]N(C1=C(Cl)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(=O)[C@]([H])(C#N)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])N([H])C5=C([H])C([H])=C(C([H])=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]23[H])C1([H])[H] [H]N1C(=NC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2C(=NN(C2=C2C([H])=C(C([H])=C([H])C2=N1)[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NN1C1=C([H])C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=C1[H])C(F)(F)F)C1=C(F)C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1C([H])([H])[H] [H]OC1=NC2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3N([H])C2=N1 [H]SC1=NN=C(N1N([H])[H])C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[H] [H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C2OC([H])([H])[C@@]3([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])[C@]3([H])C2=C1[H] [H]N(C(=O)O[C@]1([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(N2N=C(N(C(=O)C2=C1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([C@@]2([H])C([H])([H])C3=C([H])C(=C([H])C([H])=C3[C@]12[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=NC(=C(C(=O)OC([H])([H])[H])[C@]2([H])C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C(Br)C([H])=C1[H])[C@@]([H])(N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(O2)C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C(\C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(C([H])=C2[H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])=C2[H])C([H])([H])[H])C3([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)=C([H])C([H])=C1[H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2OS(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C(Cl)=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H] CN1CCN(CC1)C1CC2=C(SC3=C1C=C(C=C3)C1=CC=C(C)C=C1)C=CC=C2 [H]N(C1=NC2=C(C([H])=C([H])N2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(OC2([H])[H])[C@](O[H])([C@]1([H])OC([H])([H])[H])[C@@]1(O[C@]1([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(SC([H])([H])C2=C([H])C3=C(N=C(N=C3O[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C(=O)O[H] [H]N=C(N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N(C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C([H])=NC(=N4)C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]OC(=O)C1=C2C(=NC3=C([H])C([H])=C(C([H])=C13)C([H])([H])[H])C1=C([H])C3=C(C(=O)N1C2([H])[H])C([H])([H])OC(=O)[C@@]3(O[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C2=O)C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]12C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C2([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C4=C([H])C([H])=C([H])C(OC([H])([H])[H])=C4C([H])([H])C([H])([H])[C@@]3([H])C2([H])[H])C1([H])[H] [H]N(C([H])([H])C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])N([H])C2=O [H]OC(=O)C1=C(SC([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]N(C(=O)C1=C([H])N=C(N=C1C(F)(F)F)N([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC(=O)C1=C([H])C([H])=C(OC2=C(N([H])C(=O)C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1C(=O)O[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@]([H])(O[H])[C@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C4=C(I)C([H])=C(C([H])=C4[H])S(=O)(=O)N([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] FC1=CC=C(CN2C=CN=C2)C=N1 [H]C1=C([H])C2=C(C3=C1C([H])=C(C(=O)C3=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C2=C(C([H])=C(F)C([H])=C2[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C(N([H])C(=N2)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=C(F)C(=N2)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])=NC3=C([H])C([H])=C(C([H])=C3C2=O)N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C1=NN=NN1C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C3C(=O)C4=C(N([H])N=C4C3=C([H])C([H])=C2[H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(N=C(C([H])=C1[H])C(F)(F)F)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=NOC(=N3)C([H])([H])[H])=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(N([H])[H])C(F)=C1[H] [H]ON([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C(S1)N(C(=O)N(C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=C2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])[C@@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(C3=NC(=NN3C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1SC(=S)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)[N+]([O-])=O [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(C#N)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N([H])C(=NC(=O)C1=C([H])C([H])=C(O1)C1=C(C([H])=C([H])C(F)=C1[H])C([H])([H])[H])N([H])[H] [H]N1[C@]2([H])C(=C([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C1=C([H])N=C([H])N=C1[H] [H]N1C(=O)C([H])([H])C([H])([H])[C@@](C1=O)(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N=C2N(C(=NC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C2=C(O[C@]3(C([H])([H])[H])[C@@]([H])(OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]4([H])[C@]5(C([H])([H])[H])C([H])([H])O[C@]([H])(O[C@@]5([H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@]13[H])C([H])([H])[H])C([H])=C(OC2=O)C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=S)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(N=C2[H])N([H])[H])C([H])=C1[H] [H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C2=C3C(=NC4=C2C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H] CCCN1CCC(CC1)C1=CC=CC(OC)=C1 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(C([H])=C([H])N(N([H])C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C1=O)C([H])([H])[H] CC1=C(N(N=C1C(=O)NCCCCCNCCCCCN)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(Cl)C=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C#N)[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C(OC([H])([H])[H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] BP(=O)(OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(OC)C(=O)NC1=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=C(OC)C(=O)NC1=O [H]C1=C([H])N2C(=NC(=C2C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=N1)N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C#N)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(O1)C([H])=C1C([H])=C([H])OC1=C2C([H])([H])[C@]([H])(C([H])([H])[H])[N+]([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(SC3=C2C([H])=C([H])N(C3=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])=N1 [H]N(C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H])C([H])([H])C([H])([H])N1N=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])OC2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C1([H])[H] [H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)OC2(C([H])([H])C2([H])[H])[C@]2([H])N([C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])[C@]1([H])C2=C(SC(=C2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] OC1=C(O)C=C(\C=C\C(=O)NC2=CC=CC=C2F)C=C1 [H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C(=N1)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(N(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C(F)C([H])=C([H])C(=C1F)S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)P(=O)(O[H])O[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N1C(=S)N(C(=O)C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])=C(C(=O)N3C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C([H])([H])SC1([H])[H])C([H])([H])SC([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C4=NC(=C([H])N4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(Br)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C(OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])=C(C([H])=N1)C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[C@]1([H])N(C(=O)OC1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C(=O)O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(\N=C(/C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@](C(=O)O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1\C(=N\C(=O)C2=C([H])C([H])=C(S2)C2=C([H])N=C(O2)C([H])([H])[H])N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@@]1([H])[C@]2([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=N3)C([H])([H])[C@]12[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)[C@]4([H])[C@]([H])(C3=O)[C@]3(OC([H])([H])[H])C([H])=C([H])[C@@]4([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=C(N([H])C(=O)C2=C([H])C([H])=C([H])O2)C2=C([H])C([H])=C([H])C([H])=C2O1 [H]C([H])=C([H])C([H])([H])N([H])C1=N[C@@]([H])(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C(C(=O)OC([H])([H])[H])=C(N1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C(=C([H])S1)C([H])([H])N(C1=NC([H])=C([H])O1)C([H])([H])[H])C1=C(C([H])=C(Cl)C([H])=C1OC([H])([H])[H])C(=O)N([H])C1=NC([H])=C(Cl)C([H])=C1[H] [H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C([H])C(=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C(=S)N([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])O1)C(Cl)(Cl)Cl)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C2N=C([H])N=C2N=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])N1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=S)N([H])\N=C(/C1=C([H])C([H])=C([H])S1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)C1=C(ON=C1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1OC([H])([H])[H])C1=C(F)C(F)=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=N[C@]([H])(N(C(=N1)N([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]C([H])=C(C1=C([H])C([H])=C([H])C(=C1[H])C(N([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C(OC([H])([H])[H])=C(C2=C1C(=O)OC2([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])O[P@@](=O)(O[H])C([H])([H])[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])[C@@]3([H])N(C(=O)C([H])([H])[H])C4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]N([H])C(=N/C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)\N([H])C(=O)OC([H])([H])C([H])([H])[H] [H]C([H])([H])[C@]12C(=O)C([H])([H])C([H])([H])[C@@]1([H])[C@]1([H])C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C2/SC(=O)N(C2=O)C([H])([H])C(=O)N([H])[H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C4=C([H])C(C#N)=C([H])C([H])=C4C([H])([H])C([H])([H])[C@@]23[H])C1([H])[H] [H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(SC(=S)N1C([H])([H])[H])C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C(O[H])C([H])=C3O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O2 [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC(=N1)C([H])([H])[H] [H]OC(=O)[C@@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])OC1=C2OC([H])([H])C([H])([H])OC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H] [H]O\C(N([H])[H])=C1/C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C([H])([H])[C@@]3([H])C(=C(O[H])C4=C(O[H])C([H])=C([H])C(Cl)=C4[C@]3(O[H])C([H])([H])[H])C(=O)[C@]2(O[H])C1=O [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])O[C@]2([H])C3=C([H])C(Br)=C([H])C(F)=C3N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] C[NH+](C)[C@H](CNC(=O)c1cc(cc(c1)[N+]([O-])=O)[N+]([O-])=O)c1ccco1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(=C2C3=NC([H])=C(C([H])=C3C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N1C([H])=NC2=C1C([H])=NC([H])=C2[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] COC1=CC=C2C=C(CNCCC3=CC=C(Br)C=C3)C(=NC2=C1)C1=COC=C1 [H]N1N=NN=C1C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12)C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])SC1=NC2=C(N1[H])C(I)=C(I)C(I)=C2I [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=NN1C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2C(=N1)N([H])C([H])([H])C([H])([H])C2([H])[H] [H]\C(=C1\C2=C(SC3=C1C([H])=C(Cl)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N(C(=O)[C@@]1([H])C([H])([H])SC(=O)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(Cl)=NC(=N1)N([H])C([H])([H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]