[H]N(C(=O)[C@]1([H])C([H])=C2C3=C4C(N([H])C([H])=C4C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N([H])C(=NC1=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=NC(=C([H])N1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N1C(=O)N(C(=O)C1(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(SC(F)(F)F)C([H])=C1[H] [H]N([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C2=C([H])C([H])=NN2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=NC2=C3N1C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C2[H] [H]C1=C([H])C2=C3C(=C([H])C([H])=C(OC4=C([H])C([H])=C(C([H])=C4[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C3=C1[H])C1=C(C#N)C(=O)N=C21 [H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C1=C([H])OC2=C(C(O[H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C2=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(Cl)C(=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H] [3H]C([3H])([3H])NCCC(OC1=C(OC)C=CC=C1)C1=CC=CC=C1 [H]C1=C([H])C2=C([H])C([H])=C(Br)C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]O[C@@]1([H])C2=C([H])C(=C([H])N=C2C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C#N)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C2=C(N=C([H])N(C2=O)C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=N[C@@]([H])(C([H])([H])[H])[C@]([H])(O1)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C(C(=C([H])C([H])=C1[H])C1=NOC(=N1)C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(C#N)=C1[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(\[H])=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C(/[H])[C@]([H])(C([H])([H])[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(I)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C(N=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CN1N=C(C)C=C1C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)=C1C [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1N([H])S(=O)(=O)C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@@]([H])(C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])[C@@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])N2C(=O)C([H])=C(C3=C([H])C([H])=C(C#N)C([H])=C3[H])C([H])([H])[C@@]12[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N(C([H])([H])C1=C([H])SC([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=O)[C@]([H])(C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]OC1=NC2=C(C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])N2N=C(N=C12)C(=O)OC([H])([H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])[C@@]([H])(OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(N=C2N1C1=C([H])C([H])=C(Cl)C([H])=C1C(=N[C@@]2([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=O)C(C#N)=C(OC2=C1O[H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3OC([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N1N=NN=C1C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C(F)(F)F [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C1=C2C(OC(=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=NC([H])=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(Br)=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(Br)C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(C(=N\OC([H])([H])C([H])([H])[H])\C4=C([H])C([H])=C(Br)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])=C1Br [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C2OC([H])([H])C([H])([H])F)C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C2=C(N([H])C(=N1)C1=C([H])C([H])=C([H])N=C1Cl)C([H])=C(N([H])C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])=C2[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN2S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=NN(C(=O)N1C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C(Br)C([H])=C23)=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CN1C=NC(=N1)C1=CC2=C(C=C1)N(C=C2C1CCN(C)CC1)C1=CC=C(F)C=C1 [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C(=C([H])C([H])([H])C1([H])[H])C(=O)N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])C(=S)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1F)C(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C([H])C([H])=C(O[H])C(C3=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[H])=C3[H])=C2C([H])=C1[H] [H]N1C(=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=NC(=NO1)C([H])([H])C([H])([H])C(OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=C([H])C([H])([H])[C@@]([H])(N2C(=NC(Cl)=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1[H] [H]N1N=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])OC2=C([H])C([H])=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H][C@]12CN(CCC)Cc3cccc(Cc4c(O)c(O)ccc14)c23 CC1=CC=C(C=C1)S(=O)(=O)NC1(CCC1)C1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1 [H]OC1=NC2=C([H])C([H])=C(C([H])=C2N1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C(F)=C1[H] [H]N(C(=O)[C@]1([H])C([H])([H])[C@@]2(N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C2=C(O[C@@](C([H])([H])[H])(C([H])([H])OC3=NO[N+]([O-])=C3S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C([H])=NC([H])=C1C#N)C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1F)C1=NC(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(S1)C([H])([H])[H] [H]OC1=C(N([H])[H])C([H])=C2C([H])=C3C(=NC2=C1[H])C1=C([H])C2=C(C(=O)N1C3([H])[H])C([H])([H])OC(=O)[C@]2(O[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4N=NC([H])=C4[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=NC2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(O[H])C([H])([H])N2N=C(C3=C2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C3([H])[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]SC([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N(C1=O)C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(C1=NN(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] CN(C)C1=CC=C(C=C1)C1=NC(=CS1)C1=CC2=C(OC3=C(C=CC=C23)C(O)=O)C=C1 [H]N1C(=O)C(C2=C(N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C1=C([H])C(F)=C([H])C2=C1OC(=C([H])C2=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H] [H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N2N=NC(=N2)C2=C([H])C(C#N)=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N=C(N([H])N([H])C([H])([H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C(=C(\F)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])\C([H])([H])[H] [H]N(C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2[C@@]([H])(SC3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1N=C(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 CC(C)(C)C(=O)NCCN1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(=C1[H])N1N=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] NS(=O)(=O)C1=CC(=CC=C1)N1N=C(CO)C=C1C1=CC=CC=C1 CCOC(=O)C1=C(CC=C)N2N=C(C=C(C2=C1C(=O)OCC)C1=CC=CC=C1)N1CCOCC1 [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C2([H])[H])=NC2=C(C([H])=C([H])C([H])=C2[H])C1=O [H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C(=O)[C@]1([H])N(C([H])([H])[C@@]3([H])OC([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1F)[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C3=C(C([H])=C([H])C2=N1)N(C(=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC(=NC2=C1N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]1(OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2N1S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C(Br)C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]C1=C([H])C(Cl)=C(F)C([H])=C1OC(=O)N1C([H])([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=C(O1)C(=O)N([H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] CC(C)C1=C(CC2=CC=C(CC(N)=O)C=C2)C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN1 [H]N(C(=O)C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])S1)C1=NC2=C(S1)C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C(F)C([H])=C3[H])C2=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C#CC1=C([H])C(F)=C([H])C([H])=C1[H] [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N(C1=NC([H])=C2C([H])=C([H])C(=O)N(C2=N1)C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N2C(=O)N(C(=O)[C@@]2([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] CCCN(CCC)C1=C2C=CC=C(N2N=C1CC)C1=CC=C(OC)C=C1C [H]N([H])C(=O)C1=C([H])C2=C(S1)C(OC1=C(F)C([H])=C(N([H])C(=S)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H])=C([H])C([H])=N2 [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)[C@]([H])(C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(=NC(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=NC(=NN1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(O[C@@]([H])(C2=C([H])C(F)=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C(=O)OC1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=C(C2=C(N=C([H])N=C12)N([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C(=O)OC([H])([H])[H])C(=O)OC2=C1[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC([H])([H])C([H])([H])N(C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])O[H] [H]N1C(=O)N(C(=O)C2=C1C([H])=C([H])N=C2[H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2N1C(=O)[C@]2([H])[C@]([H])(C1=O)[C@]1([H])C([H])=C([H])[C@@]2([H])N(C1=O)C([H])([H])[H])[N+]([O-])=O [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])OC5=C([H])C([H])=C6N=C(SC6=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]23[H])C1([H])[H] C[N+]1=C(CCC(=O)NCCN2CCN(CC(=O)N3C4=C(C=CC=C4)C(=O)NC4=C3N=CC=C4)CC2)C=C\C1=C\C1=CC=C(N1[BH-](F)F)C1=CC=CS1 [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])=C(N([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N(\C([H])=N\C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N(C(=O)C1=C([H])C(Br)=C2C([H])=C([H])C([H])=C([H])C2=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C(=O)OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]S\C(=N/C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2(N([H])S(=O)(=O)C3=C(Cl)C(=C(Cl)C([H])=C3[H])C([H])([H])OC3=C4N=C(C([H])=C(C4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=C([H])N1[H] [H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(O[P@](=O)(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(=C1[H])C(=O)N([H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H] [H]O[C@@]1([H])C([H])([H])N(C2=NC(N3C([H])([H])C([H])([H])N(C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C3C([H])=C(SC3=N2)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])O1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(N=N1)C([H])([H])C([H])([H])C#N [H]N1C([H])([H])C([H])(OC2=C(OC3=C(Cl)C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]OC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])O[C@@]2(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H] [H]C1=C(N=C(S1)C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC2(C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H] C(CC[N]1=CC2=C(C=C1)C1=CC=CC=C1N2)C[N]1=CC2=C(C=C1)C1=CC=CC=C1N2 COC1=NC(C(=O)NCC2CCC2)=C(NC(=O)C2=C3C=CC=CC3=NC=C2)C=C1 [H]O[C@@]([H])(C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=NC3=C(N=C2C2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]ON(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C#CC1=NN(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@](C(=O)OC([H])([H])[H])(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] O=C(NC1=CC=CC(=C1)C1=CC=CO1)N(CCC(C1=CC=CC=C1)C1=CC=CC=C1)CCN1CCOCC1 [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1OC([H])([H])[H])C([H])([H])[H] CC(C)C[C@H](CO)NC1=NC(SCCC2=CC=CC=C2)=NC2=C1SC(N)=N2 [H]C1=C(Cl)N(C2=NC(=C(N12)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(OC([H])([H])[H])N=C2N2C(=NC(=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C(C([H])=C([H])C(Cl)=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C#N [H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2C([H])=C([H])N(C2=N1)C1=C(Cl)C([H])=C([H])N=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NC(Cl)=NC2=C1N=C([H])N2C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H] [H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]12C([H])([H])C([H])([H])[N@+](C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N1C(=O)N([H])[C@@]2(C1=O)C1=C([H])C([H])=C([H])C3=C1N(C(=O)C([H])=C3[H])C([H])([H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N2C(=O)N(C(=O)[C@]2([H])C1([H])[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])=C1[H] [H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C(N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(F)=C(F)C(F)=C2F [H]\C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N1C(=O)N(C(=O)\C(=C(/[H])C2=C(N(C3=C(C#N)C4=C(S3)C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C(N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]N(C1=C2C(=NC3=C(C(=NN13)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])[C@]1([H])C2=NC([H])=C(Br)C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C2=NC3=C([H])C(OC([H])([H])[H])=C([H])C(=C3C(=O)O2)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] C\C(NNC(=S)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC2=C(C(F)=C([H])C([H])=C2[H])C1=O)[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=O)C(=C(C#N)C#N)C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC1=C([H])C(O[H])=C2C(=O)C(O[H])=C(OC2=C1C(C([H])=C([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(O[H])=C(O[H])C(=C1[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] CN1C(N)=NC2(CC(C)(C)C(F)(F)C3=C2C=C(C=C3)C2=CN=CN=C2)C1=O [H]N(C(=O)C([H])([H])N1C(=O)OC2(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]S\C(=N/C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=O)C2=C(Cl)C(=C([H])S2)C([H])([H])N2C([H])=NC([H])([H])C2([H])[H])C(OC([H])([H])[H])=C([H])C(Cl)=C1[H])C1=NC([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(Br)=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(N=C2C(=O)OC([H])([H])C([H])([H])[H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C2=C1C([H])=C(N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])S[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C(Cl)C3=C([H])C([H])=C2C([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])O[C@@]1([H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N=C([H])C(=C2[H])C([H])([H])O[H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(S\C(=C(\[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O)=N\C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C2=C1C(=O)N([H])C([H])([H])C2([H])[H] [H]O[P@](=O)(OC([H])([H])[C@]1([H])O[C@]([H])(N2C([H])=C([H])C(=O)N([H])C2=O)[C@@]2([H])O[C@@]([H])(O[C@@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C([H])C(=O)N([H])C2=O)[C@]2([H])O[C@]([H])(O[C@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C1=NC(=NC2=C1C(=C(N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NC(=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])N1[H])[C@]1([H])[C@@]([H])(C2=C3C(OC([H])([H])C3([H])[H])=C([H])C([H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC1=NC2=C(C([H])=C(Cl)C(Cl)=C2[H])N2C([H])=C([H])N=C12 [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H] [H]N([H])C1=NC([H])=C(S1)C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] CN1CCN(CC1)[C@@H]1CC[C@@H](CC1)N1C=C(C2=C1N=CN=C2N)C1=CC(F)=C(NC2=NC3=C(O2)C(Br)=CC(C)=C3)C=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=N[H])C([H])([H])F)=C1[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [3H]C([3H])([3H])C([3H])([3H])CSC1=NC(N)=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=N1 [H]OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])C1=NC2=C(C(=NN2C2=C(Cl)C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C([H])([H])[H])C(=O)N1[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N([H])N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C3C([H])=C([H])C([H])=C([H])N3N=C1[H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(Br)C([H])=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])=O)C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C2=C(C1=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H][C@@]12CC3CC(C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)C1=C(C)N=C(C=C1)C1=CC=CC=C1 [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2N2C(=O)C(C2=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC2=C(C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])[H])C1=NC([H])=C([H])S1 [H]C1=C([H])C(C2=NN=C(N2C([H])([H])[H])[C@@]23C([H])([H])C([H])([H])[C@@](C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]1([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])OC(=O)N([H])C3=C([H])C(=NN3C([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C2S1 [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1 [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC3=C([H])N=C4N([H])C([H])=C([H])C4=C23)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NSC(N=C(N([H])[H])N([H])[H])=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]OC1=C(C(=C2N=C(SC2=C1C([H])([H])[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(O[H])C([H])=C2[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] COC1=CC=C(C=C1OCCCNC(=O)NC1=CC=C(C=C1)C(F)(F)F)C1=C(NC2CCCCC2)N2C=C(C)C=CC2=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=O)C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C(=O)C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C(O[H])(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]3([H])[C@@]4([H])C(=O)C([H])([H])[C@]5([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]5(C([H])([H])[H])[C@@]4([H])C([H])([H])C(=O)[C@]23C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C2C(=C([H])C(Br)=C1[H])C([H])([H])O[C@]2(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1=C([H])C([H])=C([H])C(N([H])C(=O)C(F)(F)F)=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C3C(Cl)=C([H])N=C(N=C(N([H])[H])N([H])[H])C3=C2[H])=C1[H] [H]OC1=C2C(=O)OC3=C(C4=C5OC(=O)C6=C(O[H])C(O[H])=C(C(C([H])=C4C([H])([H])[H])=C56)C([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C(=C23)C(=C1O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C(C#N)C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H] FC(F)(F)C1=CC=C(NC(=O)C=C)C=C1 [H]OC1=C([H])C(O[H])=C(C2=C1C(=O)C([H])=C(O2)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H] [H]OC([H])([H])[C@@]1([H])O[C@@](N2C([H])=NC3=C2N=C([H])N=C3N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]C1=C(OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C([H])([H])C([H])([H])OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])=C([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])=C([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)O[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C2/SC(=NC2=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C([H])([H])[H])(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2N2C(=NC([H])=C12)C([H])=O)C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N1N=C(C(=C1N1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(Br)=C2[H])N(C(=O)C([H])([H])[H])C3([H])[H])C(=C1[H])C(=O)OC([H])([H])[H] [H]C1=NC(C2=C3N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C2=NC3=C([H])C(OC([H])([H])[H])=C([H])C(=C3C(=O)O2)C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=NN2C(OC([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])OC([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]O[C@@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(O[H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C([H])C2=C([H])N=C(C([H])=C2C([H])=C1[H])C([H])([H])N(C1=NC(=NC2=C1C([H])([H])N(C2=O)C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] CS(=O)(=O)NC1=C2N=C(C=C(O)C2=CC=C1)C(=O)NC1=CC=CC=C1Cl [H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C2([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@]([H])(OC([H])([H])[C@@]2([H])O[C@@]([H])(OC3=C([H])C([H])=C4C(OC(=O)C([H])=C4C([H])([H])[H])=C3[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]2([H])O[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]1([H])O[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2O1)C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])N1N=NN=C1[H])C([H])([H])[H] COC1=CC=C2N(C=C(C(=O)C(=O)N3CCCC3)C2=C1)C(=O)\C=C\C1=CC=CC=C1 [H]OC(=O)C1=C(C2=C(Cl)C([H])=C([H])C(Cl)=C2N1[H])C([H])([H])C(=O)O[H] [H]C1=C([H])C2=C(S1)C(=NC1=C(N=NN21)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2=NN=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] COC1=CC=C(C=C1C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O)C1=NN=C(C)O1 [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=NOC(=N2)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C2[H])C(=C1[H])C([H])([H])[H] [H]N(C1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C([H])C(=C([H])N=C1N([H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C1Br [H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=N1)C([H])=C([H])C([H])=C2[H] [H]O[C@]([H])(N([H])[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])N=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=N1)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NN(C(=O)C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@]1([H])C([H])([H])[C@]2([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H] [H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C(F)=C(C([H])=C1[H])[S@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#C[H])C([H])([H])[H] [H]C1=C(C2=NC(=NO2)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])C(=O)N1N=C([H])C2=C1C([H])=C(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H])C([H])=C2[H] [H]N(C1=NOC(=C1[H])C1=C2N(C([H])=C(C2=C([H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C(F)=C1F [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])=NC(=C1C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(=O)N1C([H])([H])C(=O)N2[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C3=NC([H])=C([H])S3)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C(OC2=C(C([H])=C(C([H])=C2Cl)N2N=C([H])C(=O)N([H])C2=O)C([H])([H])[H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=NC2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2N1C([H])([H])C([H])([H])[H])\C(\[H])=C1\N(C2=C(C([H])=C([H])C([H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=NC([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=C(C([H])=N2)C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(OC([H])([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])[N+]([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])ON=C(C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C1([H])[H])S2(=O)=O [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1N=C(C([H])=C1C1=C([H])C(Cl)=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N1C([H])=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1N=C(OC([H])([H])[H])C(=C2[H])C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C([H])=C1[N+]([O-])=O)C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(N=C2C([H])=C(C([H])=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(N=C(N3C([H])([H])[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C1(C(=O)N([H])N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@](N([H])C(=O)[C@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]N(C(=O)N([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])N=C2N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C1=C(SSC2=C(C(=O)N([H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C2O[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C([H])=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C([H])([H])[H] CCN(CC)C1=CC=C(CN(C2=CC=C(Cl)C=C2)S(=O)(=O)C2=CC=C(F)C=C2)C=C1 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(OC(=O)C([H])([H])[H])OC(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])[H] [H]OP(=O)(O[H])[C@]([H])(N([H])[C@]([H])(C1=NN([H])N=N1)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C(C(=O)C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])(C(=O)O[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(N([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N2C(=O)N(C([H])([H])[C@]2([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(Br)C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=O)S1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C2C(=NC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N=C([H])N1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC([H])([H])C([H])([H])N(C1=C([H])C2=C(C([H])=N1)C(=NC([H])=N2)N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])O[H] [H]N(C1=NOC2=C(N=C([H])C([H])=C12)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=NC(=C([H])C([H])=C1N([H])C1=C([H])N=C([H])N=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])[C@@]2([H])C3=C(OC([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=NN(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C#CC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C(OC([H])([H])[H])C2=C(C([H])=C([H])O2)C(OC([H])([H])[H])=C1C(=O)C(=C(/[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])\C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]O[C@](C([H])([H])N([H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H])C(F)(F)F [H]N1N=C(C2=NC([H])=C([H])S2)\C(=C(/[H])C2=C([H])N(C3=C2C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2F)=C([H])C([H])=C3[H])C([H])([H])[H])C1=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(O[H])=C([H])C([H])=C1O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]OC([H])([H])C1=C(C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C([H])([H])OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(O[H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(N(C(=O)N(C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)C1=NC(=C([H])N1C([H])([H])[H])C([H])([H])C([H])([H])C1=NN2C(=N1)C(=NC([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NC(C#N)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C3N(C([H])=NC3=C([H])N=C12)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C(SC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=NC(C2=C3N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1N=O)C([H])([H])[H] [H]N(C1=NN=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])N=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(I)C([H])=C1F)C1=C(C(=O)N(C2=C1C(=O)N(C([H])=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=NC2=C(C(=NS2)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C(=O)N1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C(=O)C(N([H])C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)N([H])C4=C3C([H])=C([H])C([H])=N4)C([H])([H])C2([H])[H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@](N([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])[C@]2([H])C([H])([H])N(C(=O)C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N1C(=O)N([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(Cl)=C4Cl)C([H])([H])C3([H])[H])=C([H])C([H])=C12 [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)OC([H])([H])[H])C1=C([H])SC2=C1N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1C2=O)C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]C1=NC2=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1SC([H])([H])N1C(=O)C2=C(C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2S1(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C([H])C(=C(C([H])=C2N=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(N3C([H])=C([H])C([H])=C3[H])N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])(C([H])([H])N([H])S(=O)(=O)C([H])([H])C(F)(F)F)C1([H])[H] [H]C1=C(OC(=N1)C(=O)[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C(F)C([H])=C12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=NC([H])=C([H])O3)C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(O[H])C(O[H])=C([H])C2=C1C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C1=NC([H])=C([H])C([H])=N1 COC(=O)C1=CC=C(C=C1NC(=O)C1=NC2=CC=CC=C2C=C1)C1=CC=C(CCN2CCC3=C(C2)C=CC=C3)C=C1 [H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])[H] [H]N(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(F)(F)F)[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]N([C@]([H])(C([O-])=O)C([H])([H])C([H])([H])C([O-])=O)P([O-])(=O)OC([H])([H])C([H])([H])C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H] [H]C1=C([H])C(C(=O)N2C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3C(=C2C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(Cl)C(Cl)=C1[H] CN1CCC(=C(C1)C(=O)OCCC1=CC2=C(OCC2)C=C1)C1=CC=CC=C1F [H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])Cl)C([H])([H])C([H])([H])[C@@]21[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)N([H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])N1N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C([H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C(=O)N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=NC([H])([H])C1([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C(=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])N=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)F [H]OC1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C([H])SC(=C1[H])C1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=NC([H])=C([H])N1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=NN2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]O[C@@]1([H])[C@]([H])(N([H])[H])C([H])([H])[C@]([H])(C2=C(C([H])=NC([H])=C2[H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C(=N2)C2=C([H])C(=C([H])C([H])=C2F)C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])N(C3=C([H])N=C(Br)C(OC([H])([H])[H])=C3[H])C([H])([H])[C@]12[H] CC1=CC(O)=CC(C)=C1C[C@H](N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](C(=C)C(N)=O)C1=CC=CO1 [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C3=C(N=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C3[H])S(=O)(=O)C2=NC([H])=C([H])S2)C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C(=NC([H])=C2[H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])OC3([H])[H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1N=NC([H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=NN(C([H])=C1C1=C([H])C(=O)N2C([H])([H])[C@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]2([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C(=O)N(N=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C#N)=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])N2C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C(F)(F)F)C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C1=C([H])C(=NC2=C(OC([H])([H])C3=C(Cl)C([H])=NC([H])=C3Cl)C([H])=C([H])C([H])=C12)C([H])([H])[H] CC1(C)OB(OC1(C)C)C1=CC=C(N\C(S)=N\C2=CC=C(C=C2)S(=O)(=O)NC2=NN=C(S2)S(N)(=O)=O)C=C1 [H]OC(=O)C([H])([H])[C@]([H])(C(=O)O[H])C1=C([H])C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]