[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])[C@]2([H])C(=O)N(C(=O)[C@]2([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]C1=C2C(=O)OC([H])([H])C([H])([H])C2=C([H])C2=C1[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C(N=C2[H])N([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C(\C([H])=C(/[H])C3=NC4=C(C([H])=C([H])C(Cl)=C4[H])C([H])=C3[H])=C2C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])N([H])C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1N=C([H])C2=C1C([H])([H])C([H])([H])C1=C2N(N=C1C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N([H])[C@@]1([H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])SC(=O)C([H])([H])[H])C(=O)[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
[H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Br)=C([H])N=C3[H])N2C([H])([H])C([H])([H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H]
[H]N(C(=S)N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=NC([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C3=C2C2=C(C4=C(C([H])=C([H])N4C([H])([H])[H])C([H])=C2[H])C2=C3C(=O)N([H])C2=O)C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=NN(C(=C2C([H])([H])C#N)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]C([H])=C([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N=C2N(C1([H])[H])[C@](O[H])(C1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=NC([H])=C2N([H])N=C(C2=C1[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C(F)=C1[H])C([H])([H])[H]
[H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C(\[H])=C(/[H])[C@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1SC([H])([H])C(=O)C1=C(N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#CC2=C([H])N=C([H])N=C2N([H])C2=C([H])C(Cl)=C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N1C2=C([H])C([H])=C(C#N)C([H])=C2C([H])([H])[C@@]([H])(N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=N2)C1([H])[H]
[H]OC(=O)C(=N\O[C@]([H])(C1=C([H])C2=C([H])C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])C([H])=C2S1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C2=C1OC(=O)N2C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(O[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C2N([H])C([H])=C(C2=C(C([H])=N1)C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H]
[H]OC1=C2N([H])C(=NC2=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1S(=O)(=O)N1C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@@]([H])(C([H])([H])OC([H])([H])[H])[C@@]1([H])O[H])N1C([H])=C(C2=C1N=C([H])N=C2N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C2C3=C(SC(=C3C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C(=C2N=C(SC2=C1C([H])([H])[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N1C(=O)C2(N([H])C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1=C([H])N([H])C(=O)C3=C([H])C(Cl)=C(Cl)N13)C([H])([H])C2([H])[H]
[H]N(C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])=C(O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])N(C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=NN=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C(C3=C(N=C(N=C3N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])[H])N([H])[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N([H])C1=C([H])C([H])=C(F)C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=N\N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C(=C2N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C2=C1Cl)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC1=C(F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C2=C(SC(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C2=C([H])N=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(C(Cl)=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])N([H])[H])[C@@]1([H])O[H])N1N=C(I)C2=C(N=C([H])N=C12)N([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C1([H])[H]
[H]SC1=NC2=C(N=C(C3=C([H])C([H])=C(C([H])=C3[H])N3C4=C([H])C([H])=NC([H])=C4N=C3C([H])([H])[H])C1([H])[H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])=C1OC([H])([H])[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(\N=C(/[H])C1=C(C([H])=C([H])S1)C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H]
BrC1=CN=CC(COCC2(CCNCC2)C2=CC=CC=C2)=C1
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C(C([H])=NC2=C1C([H])=NN2C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])C([H])([H])C(=O)OC([H])([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(C#N)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C(C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(N=C3C([H])=C([H])C([H])=C([H])C3=C2C(=O)N([H])[C@@]([H])(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C(F)(F)F)N=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C([H])=C([H])C3=C([H])N=C([H])C([H])=C23)C1([H])[H]
O=S(=O)(NC1=NC(NCCC2=CC=CC=C2)=NC2=C1CN(CC1=CC=CC=C1)CC2)C1=CC2=CC=CC=C2C=C1
[H]N(C(=O)C1=C([H])C([H])=C(O[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NN([H])N=N1
[H]N=C(N([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(C([H])=C2C2=C1C(=O)N(C2=O)C([H])([H])C([H])([H])OC(=O)C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(OC([H])=C2C([H])([H])N([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=N1
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(OC([H])([H])C(=O)N([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H])[N+]([O-])=O
[H]N1C(=O)N(C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C(N([H])C2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]1([H])O[H]
[H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C(=O)N1C2=C(OC([H])([H])C([H])([H])C1([H])[H])C(=O)N(N=C2[H])C([H])([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1S2)C1=C([H])SC([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])N(C3=NC(OC([H])([H])[H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=NN(N=N1)C1=C([H])C(F)=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(Cl)=C(C([H])=C1[H])[C@]1([H])N=C([H])N([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1Cl
[H]N1N=C(N=C1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H][C@@]12C[C@@H]3C[C@@H](C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)CN1N=NN=C1CCC1=CC=CC=C1
CN1CC[C@@H](C1)OC1=C(C=CC(NCC2=C(Br)C=CC=C2)=C1)C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=NN=C(O1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C2=C(C([H])=NC([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=C(Cl)C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C([H])([H])OC1=C(Br)C([H])=C(\C([H])=C2/SC(=O)N(C2=O)C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NC2=C(OC3=C([H])C([H])=C(Br)C([H])=C23)C(=O)N1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(N=C(N=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN=C(SC([H])([H])C([H])([H])[H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(SC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])SC([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
COC1=CC=CC(OC)=C1CNC(=O)NC1=CC=C(C=C1)C1=CNN=C1
[H]ON(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C#N)C(=N\C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])\N1C([H])([H])C([H])([H])C(=C2C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])SC1=NC(=C(N1C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=NC([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC([H])([H])C([H])([H])[C@]1([H])N(C(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(N([H])C3=NC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N3[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(Br)N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C2N=C(C([H])=NC2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C2=C([H])C(Cl)=C([H])C([H])=C2\C([H])=C(/[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=O)C1=O
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)OC(C2=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])[H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H]
[H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=NC([H])=NC2=C([H])C3=C(C([H])=C12)N(C(=O)O3)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)C([H])([H])C1=C2C([H])=C([H])OC2=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=NN2C([H])=C(Br)C([H])=NC2=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])SC2=NN=C(N2C([H])([H])C([H])([H])[H])C2=C([H])C3=C(O2)C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C(F)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]C1=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NS1)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C(N=C1N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=N1)C(=O)N([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])[C@@]1([H])O[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C([H])=C2S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N1C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])[C@@]23C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N(C(=O)N([H])C2=C([H])C(Cl)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O
[H]N1C(=C(C(=O)OC([H])([H])[H])[C@@]([H])(C2=C([H])C(C#N)=C([H])C([H])=C2[H])C(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)N=C([H])C([H])=C3[H])C([H])=C21)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F
[H]N(C1=C([H])C(=NN(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(S2)C(\[H])=C2/SC(=S)N(C2=O)C([H])([H])C(=O)O[H])C1=O
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1C1=C([H])C(F)=C(OC([H])([H])[H])C(F)=C1[H]
[H]N(C(=O)OC([H])([H])[C@]1([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C#CC([H])([H])N1C([H])([H])C([H])([H])[C@@]23C4=C([H])C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC5=C([H])C6=C(C([H])=C5[H])C([H])([H])[C@@]5([H])N(C([H])([H])C#C[H])C([H])([H])C([H])([H])[C@@]66C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]56[H])=C([H])C([H])=C4C([H])([H])[C@]1([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(Br)C([H])=NN3C(=N2)N([H])C2([H])C([H])([H])C2([H])[H])=C1[H]
[H]C1=NC(=NC([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(Cl)=C([H])OC3=C([H])C([H])=C([H])C([H])=C3C2=O)C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1N([H])[H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])N=C([H])C(=C1[H])C(=O)N([H])C1(C(=O)N([H])[C@@]([H])(C2=C(F)C([H])=C(C([H])=C2[H])N2N=C(Cl)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H]
OC(=O)C1=C(CCCOC2=CC=CC3=CC=CC=C23)C2=CC=C(Cl)C=C2S1
[H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C#CC([H])([H])OC1=C([H])C([H])=C2C(OC3=C(C([H])=C([H])C([H])=C3[H])C2=O)=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(OC(=O)C([H])([H])C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C(O[H])C(=O)C2=C([H])C(=C([H])C(N3C(=O)N(C([H])([H])[H])C([H])([H])C3=O)=C2O1)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])[C@@]1([H])N(N=C(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H])C1=NC(=O)C([H])([H])S1)C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(I)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=NC(=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=N/OC([H])([H])[H])\C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])[C@]1([H])O[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2C([H])([H])OC([H])([H])C([H])([H])F)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]C1=NC2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(N([H])C(=O)[C@@]2([H])N(C(=O)N([H])C3=C([H])C(F)=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(O[H])C(O[H])=C1[H])C([H])([H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H]
[H]O\N=C(/C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])N([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C(C2=NC(=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C([H])=N2)C([H])=C1[H]
[H]N1C(=O)N([H])[C@@]2(N(C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])[H])C1=O
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C(C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])[P@](=O)(N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C3=C(C([H])=C([H])C(C1=O)=C23)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=NC3=C(N2C([H])=C1[H])C(=O)N(C(=O)N3C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C2=C3C([H])=C([H])C([H])=C(OC([H])([H])[H])N3N=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=O
[H]OC1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C(F)=C([H])C([H])=C2C1=O
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C(=C(N([H])\N=C(/[H])C2=C(Cl)N(N=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C2([H])[H]
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1([H])C([H])([H])N(C([H])([H])C([H])([H])C(\[H])=C(/[H])C2=C([H])N=C([H])C(C#N)=C2N([H])C2=C(C3=C(N([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])[H])=C(SC([H])(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C2=C3N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(SC3=C2C([H])=C(C([H])=C3[H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C2C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C1C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]N([H])C1=NC2=C(C3=C(S2)C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C3([H])[H])C(=O)S1
CCC1=CC2=C(CC(C2)NCC(O)C2=C3C=C(C)C(=O)NC3=C(O)C=C2)C=C1CC
[H]N(C([H])([H])C1=C([H])C([H])=C(C#CC2=C(Cl)C([H])=C([H])C(=C2[H])C2=NN(C3=C2C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]1([H])C([H])([H])C([H])=C([H])[H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]C1=C([H])C(Cl)=C(Cl)C(=C1[H])C(=O)C(=O)N1[C@@]2([H])C(=O)N3C([H])([H])C([H])([H])C4=C(C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C4[H])[C@]3([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C(=O)N([H])C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C(=O)N([H])[H]
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC1=NN([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=C(C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C(=O)C([H])([H])[H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C1=O
[H]C1=C(OC2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CCCSC1=CC=C(C=C1)S(N)(=O)=O
[H]N(C(=O)[C@@]([H])(OC(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]C1=C(SC2=C1N=C(N=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(C1=NN=C2N1C([H])=C(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)N[C@H]1C[C@@H]1C1=CC=CC=C1
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(N1C(=NN=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H]
[H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@@]13O[C@]4(O[C@@]([H])([C@]1([H])C([H])=C(C([H])([H])OC(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(N([H])[H])C(F)=C1[H])C2([H])[H])[C@@](O4)(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C(Cl)C([H])=C([H])C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])=[N+]1[O-])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C([H])C([H])=C(Br)C2=C1[H])N1C(=O)[C@@]2([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C1=O
[H]N([H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(C3=C2C([H])=C([H])C([H])=C3[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C([H])SC([H])=C2[H])C([H])=C1[H])C([O-])=O
[H]OC(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(N=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C([H])=C([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])[N+]([O-])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N=C1OC1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])S1)C([H])([H])[H]
[H]C1=C(SC2=C1C([H])=NN(C2=O)C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=[N+](C([H])=C(S1)C([H])([H])[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N(C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C(Br)=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2C1=O
[H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3F)C(=C2[H])C2=C([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]C1=NC(OC2=C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C(OC2=O)(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C1=NN=C2C(F)(F)F)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S[H]
[H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1(C([H])([H])OC2=C([H])C([H])=C([H])C3=C([H])C([H])=C(N=C23)C2=NN=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H]
[H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])[H])[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=N1
[H]SC1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(\[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H])C([H])([H])F
[H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C([H])N(N=C3C(=O)C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])OC(=O)C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(Br)=C(F)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])N(N([H])[H])C([H])([H])[C@@](N([H])[H])(C(=O)O[H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C2=NC([H])=C([H])N2[H])C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C2=C(N=C([H])O2)C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C(=O)C([H])=C(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C(=C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
CC1=C(C)C(NC(=O)N2CCN(CC2)C2=NC(=CS2)C2=CC=CC=C2)=NO1
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(O[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C([H])([H])C(=O)O[C@@]1([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]1([H])[C@]([H])(N([H])[H])C([H])([H])N(C2=C(C([H])=NC([H])=C2[H])C([H])([H])C(=O)C2=C([H])C([H])=C([H])C(=N2)C2=C(F)C(=C([H])C([H])=C2F)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C([H])=C2C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(O1)C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2OC(=C([H])C2=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]N(C1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2(C3=C([H])C([H])=C([H])C([H])=C3[C@@]1([H])C1=C2C([H])=C([H])C([H])=C1[H])[N+]([O-])=O)C1=NC([H])=C([H])S1
[H]C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=C([H])C([H])=C1F
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1Br)[N+]([O-])=O)[N+]([O-])=O
[H]N([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(SC(=C2[H])C2=C([H])OC([H])=C2[H])N2C1=NC([H])=C2C([H])([H])[H]
[H]O[C@@]12C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]11C3=C(C([H])=C([H])C(OC(=O)[C@@]([H])(C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])[H])=C3[H])C([H])([H])[C@@]2([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C3=C([H])C([H])=NC(=C3[H])C(F)(F)F)C([H])=C2[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])=C([H])C([H])=C1C2=O
[H]N([H])C(=O)[C@@]1(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=N2)C([H])([H])C2([H])N(C([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C(Cl)C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C(OC(F)(F)F)C([H])=C(Br)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C(=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C(Cl)=C([H])C(Cl)=C2C(=O)[C@](C1=O)(C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])[H]
FC1=CC=CC2=C1CCC(=O)N2CCCN1CCC(CC1)NC(=O)CC1=CC=CC=C1
[H]N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])O1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C2N(C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[N+](=C2C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(C([H])=C34)C3=C([H])C([H])=C([H])N=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1(C2=C([H])C([H])=C(S2)C2=C([H])C([H])=C([H])S2)C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])\C(=N/OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N=C(N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])OC([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(C([H])=C2N2C([H])=NC([H])=C12)N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(SC1=C([H])C([H])=C(Cl)C([H])=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C(=C([H])C3=C2N1C(=O)C([H])([H])C3([H])[H])C(=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N=C(N([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2OC([H])([H])[H])C(=N[H])N([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N(C(=O)[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#CC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])SC([H])([H])[C@@]2([H])N([H])C(=O)N([H])[C@@]12[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1\C(=N\C(=O)C2=C([H])C([H])=C(S2)C2=C([H])N([H])N=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1N=NC2=C(N=C(N=C12)C([H])([H])[H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O\N=C(\C(=O)N([H])C([H])([H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]C1=NC(C#CC2=C([H])\C(=N\OC3=NC([H])=C([H])C([H])=C3F)C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N2N=C([H])C3=C(N=C(N=C23)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])[H])C([H])=C2[H])N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC([H])([H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])N(C1=C([H])C([H])=C2N=C(N([H])[H])C3=C2C1=C([H])C([H])=C3[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])[H])C([H])=C2N2C([H])=NC([H])=C12)C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])N(N=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H])C([H])([H])[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C(C([H])=C(C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(C2=C(N=C1C([H])([H])[H])C(=O)N(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC([H])([H])C1(N2C([H])([H])C([H])([H])C([H])(N3C(=NC4=C3C([H])=C([H])C([H])=C4[H])N3C([H])([H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
Cl[H].NC(=N)NC1=CC=C(O)C=C1
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C2=C(SC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])O2
[H]C1=C(N2C(=[N+]1C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CN(C)CCCN1N=C(C2=C1C=CC(OC(F)F)=C2)C1=NC2=C(NC=C2C(=O)NC(C)(C)CO)N=C1
[H]OC1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(O[H])C([H])([H])N2N=C(C3=C2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C3([H])[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@](C#CC1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(N([H])[H])=[N+]([H])[H]
[H]N(C1=NC([H])=C2C(=O)N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])N3C2=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]S\C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C1\C([H])=C([H])C(=O)C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=NC(C2=NN=C(S2)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C(=NC(=C1C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(\C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C(Cl)N(C2=NC(=C(N12)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C(F)(F)F)C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])C(=O)[C@@]([H])(N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2O1
[H]N(C1=NC([H])=NC2=C1N([H])C([H])([H])C1=C(O2)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C2=NN([H])C([H])=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C2([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[N@+](C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C(=O)N([H])[H]
[H]OC1=C2C(=O)N(C([H])([H])C([H])([H])C3=NC([H])=C(F)C([H])=N3)[C@@]([H])(C(=O)N([H])C([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C2=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])S1
[H]N(C(=O)C1=C([H])C(Cl)=C([H])N=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(OC4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)C([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C(F)C(F)=C([H])C(F)=C2F)C([H])=C1[H]
[H]N(S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NN1C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C(=O)C1=C([H])C(=C([H])S1)[C@]([H])([N+]#N)C(F)(F)F
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N([H])C2=C([H])C(C3=NC([H])=NC([H])=C3[H])=C(N=C12)C1=C([H])C([H])=C([H])O1
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@](C#N)(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=NC2=C(S1)C([H])=C([H])C(N([H])C(=O)C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])=C2[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C1=C([H])SC(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H][C@@]12CC3CC(C3(C)C)[C@]1(C)OB(O2)[C@H](CCCN=C(N)N)NC(=O)C1=CC=C(C(N)=C1)C1=CC=CC=C1
[H]N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=N2)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H]
[H]N(C1=NC(=O)[C@](S1)(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C(Br)C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=N1)C([H])([H])[C@@]1([H])\C(=C(\[H])C([H])([H])[H])[C@]2(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
CC(COC(=O)C(C)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1)ON(O)=O
[H]N(C(=O)N1C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)[C@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2C([H])=N1)S(=O)(=O)N1C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C(=NC([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C#CC([H])([H])N([H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])[H]
NC1=NC2=C(S1)C=C1CCN(CCC1=C2)C(=O)C1=CC=CC=C1
[H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C(F)(F)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(F)C([H])=C(C([H])=C1N1C(=O)N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)[C@]([H])(C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)[C@]23C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]2([H])C2=C([H])C([H])([H])[C@]4([H])[C@@]5(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]5([H])C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]2(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C(=NC2=C(Br)C([H])=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]C1=C([H])N2C(=C1[H])[C@]([H])(O[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C21)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N1C2=C(C([H])=C([H])C(N([H])C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C([H])=C4[H])=C2[H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C(C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(OC([H])([H])[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Br)C([H])([H])C1([H])[H])[N+]([O-])=O)[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(C3=C(C([H])=C(F)C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1(C([H])([H])[H])C([H])([H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C2=C([H])OC([H])=C2[H])[C@@]2(C([H])([H])[H])[C@@]([H])(OC(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]3([H])C([H])([H])[C@]12OC3(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=N[C@@](N(C(=N1)N([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C#N)C([H])=C1Cl)C1=C(C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(N=C([H])C([H])=C2N1[H])C1=C(Br)C(=C(Br)N1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=N1)C1=C([H])N2C(=NC(=C2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C2N=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])N=[N+]=[N-])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])C1=C([H])C(I)=C([H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NN2C(=N1)C([H])=C([H])C([H])=C2C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])\C(=C(\[H])N([H])N([H])C(=S)N([H])C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])=C([H])C1=O
[H][C@]12C[C@]3([H])C[C@]([H])(C1)C[C@](C2)(C3)N(CC1=CC=C(C=C1)N(CC)CC)C(=O)CCCCCCC
[H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@](C([H])([H])[H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C(N=C([H])N3C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C1([H])[H]
[H]OC([H])([H])C1=C([H])C(=C(N([H])C(=O)C2=C([H])C([H])=C3N=C(SC3=C2[H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N(C(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(=C3[H])C2=NN([H])N=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C1=NC(=NC(=C1[H])C([H])([H])[H])N(C1=C(Br)C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1(C2=C([H])N=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[C@]1([H])C(=O)C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=C(N([H])C(=O)N([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C#N
[H]N([H])C1=C(C([H])=NC2=C([H])C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H])C(=O)C([H])([H])[H]
[H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=S)N(C(=S)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@@]([H])(N1C([H])([H])C([H])([H])C2(N(C([H])([H])C(=O)N([H])C3=C([H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C2[H])C1([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C3=C2N(C2=C3C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@]1([H])C([H])([H])[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C(F)(F)F
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C1=C(C2=C(N=C1C([H])([H])[H])C(=O)N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])(C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)OC1=C([H])C([H])=C2N=C(SC2=C1[H])S(=O)(=O)N([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C(=O)N1N(C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C(OC(F)(F)F)C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@]1(OC(=C(C#N)C#N)C(C#N)=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NC([H])=NC2=C1C(=C(O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=C1\N=N\C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(O[H])=C1O[H])S(=O)(=O)O[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]3([H])N(C(=O)[C@@]4([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[C@@]([H])(O[H])C3([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])O[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C(F)(F)F)C(F)(F)F
[H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C([H])C(=C23)C1([H])[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3OC(=C([H])C(=O)C3=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C2C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SSC1=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]2([H])C1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C(N([H])C(=O)C([H])([H])O[C@]3([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N(C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1=NC(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC([H])=C1C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N1C(=O)N(C2=C(C([H])=NC([H])=C2[H])C1=O)C([H])([H])C1=C([H])N(C2=C1C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])=C([H])[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N([C@]1([H])C3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[C@]21C(=O)OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C(N([H])C(=O)C2=NOC(=C2[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=S)N([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C([H])([H])C#CC([H])([H])O\N=C1/C([H])([H])[N@@]2C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(\C#N)=C(\[H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C3=NC([H])=C([H])C([H])=C23)=C2C([H])=C([H])N([H])C2=N1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=N3)C3=C([H])C([H])=C([H])C(Cl)=C3Cl)[C@]3([H])[C@]([H])(OC(=O)[C@]3([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]OC1=NC2=C(O1)C(=C([H])C([H])=C2O[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC([H])=C([H])S1
[H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])O[C@@]([H])(O[C@]1([H])C1=C(O[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])\C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C2C([H])=NN1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1Br)C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C1N2C(SC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=NSC2=NC(=O)\C1=C(\[H])C1=C([H])C([H])=C([H])S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C(=O)C1=C([H])C([H])=C(N=C=S)C([H])=C1[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])N(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])C3=C([H])C(=C([H])C([H])=C3[C@@]([H])(C([H])([H])[H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=O)C(N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C1=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])N21)C([H])([H])[H]
[H]N([H])C1=C2C(=NC3=C1C([H])=C(O3)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])N([H])C2=C(SC([H])=C2[H])C1=O)[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])N(C2=C1C([H])=C1C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(C1=C([H])N=C(S1)N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1[H])(C(F)(F)F)C(F)(F)F
[H]OC(=O)[C@]([H])(N1C(=O)N(C2=C([H])C([H])=NC([H])=C2C1=O)C([H])([H])C1=NSC2=C1C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12F
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C2C([H])=NN(C2=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)[C@]1([H])N(C([H])([H])C2=C(OC([H])([H])[H])C([H])=C3N=C([H])N=C(N([H])C4=C(F)C(Cl)=C([H])C([H])=C4[H])C3=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H]
[H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(F)(C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C2=NC3=C(C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])([H])[H])N2C([H])([H])[H])=C1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N1C2=C([H])C([H])=C(N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C#N
[H]O\N=C1\C(\N([H])C2=C\1C([H])=C([H])C([H])=C2[H])=C1\C(=O)N([H])C2=C([H])C(Br)=C(C([H])=C12)[N+]([O-])=O
[H]N(C1=NOC2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N=C([H])S2)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(O[H])C([H])=C(\C([H])=C(/C#N)C(=O)N([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C1=NN(C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C(O[H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1[C@@]2([H])C(C(=O)N(C([H])([H])C3=C(C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C3([H])C([H])([H])C3([H])[H])=C(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])OC4=C(Cl)C([H])=C(C([H])=C4Cl)C([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]OC(=O)[C@@]([H])(OC1=C(F)C([H])=C([H])C(=C1[H])C([H])([H])N1C2=NC(F)=C([H])C([H])=C2C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4[H])C([H])=C([H])C(=C5[H])C([H])([H])N([H])C(=N[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])[C@]2([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C2=C1C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C2([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C(OC2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H])\C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])[N+]([O-])=O)=C([H])N=C1[H]
[H]N([H])C(=O)C1=C2N=C(C([H])=NC2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C(=NN1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2\C(=C(/[H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C(C(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])[H])C(=N1)N1C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C(=NN1C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])=C(F)C([H])=N2)C([H])=C1[H]
[H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(\N=C(\[H])C1=C([H])C([H])=C([H])S1)C1=NC(=C([H])S1)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C4OC([H])([H])C([H])([H])OC4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[C@@]([H])(N([H])C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=N3)C3=C([H])C([H])=C([H])C(C#N)=C3[H])[C@]3([H])[C@]([H])(OC(=O)[C@]3([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])[C@@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C(Cl)=C(\N=C(/N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H]
COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CN=CC(=C3)C3=CC=C(O3)C(N)=O)C2=O)C=C1
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C1C1=C([H])C([H])=C([H])C3=C1C(=O)N([H])C3([H])[H])C([H])=C(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC([H])([H])C(\[H])=C1\C([H])([H])[N@+]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C5=C([H])C([H])=C([H])C([H])=C5N5\C([H])=C6/[C@]7([H])N(\C([H])=C(/[C@@]35[H])[C@@]1([H])C([H])([H])[C@]24[H])C1=C(C([H])=C([H])C([H])=C1[H])[C@@]71C([H])([H])C([H])([H])[N@@+]2(C([H])([H])[H])C([H])([H])\C(=C(/[H])C([H])([H])O[H])[C@]6([H])C([H])([H])[C@@]12[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])([H])O1
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)N([H])C1=C(C([H])=C(C(Cl)=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C(C([H])=C(C(Cl)=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H]
[H]N([H])C1=NC(=C([H])C(=N1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(F)C([H])=C(N([H])C3=NN4C(=C([H])C([H])=C4C4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])=N3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C1=NC2=C(C(=NN2C2=C(Cl)C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C([H])([H])[H])C(=O)N1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1OC([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=C(N1[H])C([H])=C(C(=N[H])N([H])[H])C(F)=C2[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=N1)N([H])[C@@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@](N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])[C@@]1([H])O[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=C(C(Cl)=C([H])C([H])=C1C([H])([H])[S@@](=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H]
[H]ON([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C2=NC([H])=C([H])S2)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C3N(N=C2C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])N1C([H])([H])[H]
[H]C1=C(C(N2C3=C(N(C(=N3)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C2([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])OC(=O)C1=C(Cl)C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C2=C(N=C([H])N=C2N(C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])S2)C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C(=O)N1[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(SC([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
Cc1ccc(cc1)-c1csc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)N[C@H](CO)c2ccccc2)n1
[H]N([H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C(=C1[H])C1=C([H])N=C2N([H])C([H])=C(C2=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(C([H])([H])OC(=O)C([H])([H])[N+](C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[H])C1=C(O[H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(N1[H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H]
[H]N(C(=O)C1=NC(=C([H])C([H])=C1N([H])C1=C([H])N=C([H])N=C1[H])C1([H])C([H])([H])C1([H])[H])C1=NN(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H]
[H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])N=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C2N=C(SC([H])([H])C#N)N3N=C(N=C3C2=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC(=O)[C@]12C([H])([H])C([H])([H])[C@@]([H])(C(=C([H])[H])C([H])([H])[H])[C@]1([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])=C([H])[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C2=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3OC2=O)C([H])([H])C1([H])[H]
CCOC(=O)C1=CC=C2N3C(=NN=C3C3=CC=CC=C3)C(C)=NC2=C1
[H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C(=C1C#N)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C2=C1OC(=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC([H])([H])[C@]1([H])OC([H])([H])C([H])([H])N(C2=C([H])C(=O)N3C([H])=C([H])N(C3=N2)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C1([H])[H]
[H]N(C([H])([H])C([H])([H])SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C1=NC([H])=C(N1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1F
CN1N=C(C)C(C(=O)N2CCCCC2C2=CC=CN=C2)=C1OC1=CC=CC=C1C(F)(F)F
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C1=O
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=NC(=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])N=C(Cl)C(F)=C1[H])C2([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC(=O)C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])=C([H])C([H])=C2C([H])([H])N(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])=C(C1=C([H])SC(=N1)C([H])([H])[H])C(=O)O2
[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C([H])C(O[H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C1=C2C([H])=NC(=NC2=NN1[H])N([H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(O1)C1=NN2C(=N1)C1=C([H])N(N=C1N=C2OC([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])O[H]
[H]C1=C([H])C([H])=C(O1)C(=O)[C@@]1([H])N2C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C3[C@]2([H])[C@@]2([H])C(=O)N(C(=O)[C@@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C2N(N=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=NN2C([H])=C(C([H])=C12)C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C(N=C(O1)C1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C2N=C([H])C(=C([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(OC([H])([H])C1([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])N(C(=O)C(Cl)=C1N([H])C1=C([H])C([H])=C(Br)C([H])=C1F)C([H])([H])[H]
CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)C(=O)C(=O)NCCCN1C=CC(N)=NC1=O
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C([H])N=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H]
[H]N(C(=O)C1=C(Cl)C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC2=C(O1)C([H])=C([H])C([H])=N2
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S[H])C([H])([H])C(=O)O[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N2C(=O)[C@](N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]3([H])N(C(=O)[C@@]4([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[C@]([H])(O[H])C3([H])[H])C([H])([H])C3=C([H])C([H])=C([H])S3)C([H])([H])O[H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=NC3=NC([H])=NN23)C([H])=C1[H]
[H]\C(=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)OC1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])[H])C2=NC([H])=C([H])C([H])=C12
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C(C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C(OC([H])([H])C1=O)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(C#N)=C1[H]
[H]OC(=O)C1=NC(C2=C([H])N([H])C([H])=N2)=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])[C@@]2([H])C1([H])[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
NC(=O)C1=C(OC(=C1)C1=CC=NC(N)=N1)C1=CC=CC=C1
CC(C)(C1=CC(=NC(=N1)C1=CC=CC2=C1C=CN2)N1CCOCC1)S(C)(=O)=O
[H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C1[H]
[H]\C(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])=C1\C(=O)OC2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]C1=C([H])C([H])=C2C(=O)C3=C(C(=O)C2=C1[H])[C@@]1([H])OC(=O)C([H])([H])[C@@]1([H])O[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC2=C(C(=N1)C1=C([H])C([H])=C(Br)O1)C([H])([H])C1=C2C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])S[C@@]([H])(N(C1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C2=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@@]([H])(C2=C(C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23
[H]OC(=O)[C@@]1([H])[C@@]([H])(C2=C(C([H])=C([H])C([H])=N2)[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@@]1([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H]
CCC1=NC(N)=NC(N)=C1C#CC(C)C1=CC(=CC(OC)=C1)C1=C2C=CN=CC2=CC=C1
[H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])N(C2=C([H])C([H])=C(C([H])=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]1([H])C([H])([H])[C@](C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])(C3([H])[H])C2([H])[H]
[H]C([H])=C(Cl)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
COCCCN1C(NC(=O)C2=CC=CC(=C2)C#N)=NC2=CC(=CN=C12)C(=O)N(C)C
[H]C1=C(C([H])=C(C(C#N)=C1[H])C(F)(F)F)N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@]1(O[C@]2(C([H])([H])[H])C([H])([H])N(C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])N1[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])[C@@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NN=NN1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2(C(=O)N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C1=O
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C#N)C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1O2
[H]N([H])C1=NC(=C([H])C(=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])O1
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C#N)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C2O[C@@]([H])(N([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=NC(=C(C([H])=C1[H])C1=NC(=C2N1C1=C([H])C(=C([H])C([H])=C1N=C2C([H])([H])[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C(=O)N([H])N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(N([H])[H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C1C(=O)N(C1=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])N21)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=N1)C1=C(C([H])=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=NN=C(O2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C(Cl)N=C(Cl)N1C1=C([H])C([H])=C(F)C([H])=C1F)S(=O)(=O)C([H])([H])[H]
[H]N(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C#CC2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C(SSC2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)O[H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC(=O)[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]O\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])N2C(=NC3=C(C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C2=O)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC=CC(=C3)C(F)(F)F)C=C1)=NC=N2
[H]C1=NN(C([H])=N1)C([H])([H])[C@]1(OC([H])([H])[C@]([H])(Br)C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C1=C([H])SC(=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)O\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
COC1=CC=C(\C=C\C=C\C(=O)C2=CC(F)=CC=C2O)C=C1
FC1=CC2=C(CCC(=O)N2CCCN2CCC(CC2)NC(=O)CC2=CC=CC=C2)C=C1
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=C(Cl)C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N1)C([H])([H])[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC(=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])=C2N=C([H])N([H])C2=N1
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C(OC2=NC(=C([H])C([H])=N2)C2=C(N=C([H])N2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2SSC2=C(N([H])C1=O)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C([H])=C([H])C2=C1C(Br)=C([H])C([H])=C2[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C(F)=C([H])C([H])=C23)S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H]
[H]C1=C([H])C2=C(S1)C([H])=NC([H])=C2SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=C(Cl)C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)C([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=NO[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])[H])[C@@]1([H])C(=O)N(C(=O)C([H])([H])C([H])([H])C([H])=C([H])[H])[C@]1([H])OC(=O)C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(C([O-])=O)=C1C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H]
[H]OC([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N(C2=C3C(=C([H])C([H])=C2[H])N(C([H])=C3C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C1N(C(=C2SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(C([O-])=O)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]\C(=C1\SC(=S)N(C1=O)C([H])([H])C([H])([H])[H])C1=C(N(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C2=C(C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C2=C(N=C(C3=C([H])C([H])=C([H])O3)C(=N2)C2=C([H])C([H])=C([H])O2)C([H])=C1[H]
[H]N1C([H])=C([H])N(C1=O)C1=NN(C([H])=C1[H])C1=C2C(=NC(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)OC([H])([H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(SC(SC2=NN=C(SC3=NC([H])=C(S3)[N+]([O-])=O)S2)=N1)[N+]([O-])=O
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N(C1=C([H])C([H])=NC(=N1)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(C([H])=C(S2)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
COC1=C(C=C(C=C1)C1=NNC(=N1)C1=CC=NC=C1)N(O)=O
[H]N=C(N([H])[H])C([H])([H])C1=C(N(N=C1C(=O)N([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C1SC([H])([H])C(=O)N1C1=NC([H])=C(S1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])SC([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N1C(=C(C#N)[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C(=O)N1C([H])([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])[C@@]([H])(N1C([H])([H])[C@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C(N=C(S1)\N=C1/OC([H])([H])C2(C([H])([H])N1C(=S)SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C(Cl)=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1F)N(C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C(=O)O[H]
CC1=CN=C(CNCC2(O)CC3CCC(C2)N3C(=O)C2=CSC=C2)C=C1
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O[H])C(O[H])=C(O[H])C(OC([H])([H])[H])=C2O1
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N=C(O3)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C(=O)C1=C(OC2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H]
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(OC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])[H])[C@]2([H])[S@@](=O)[C@@]1([H])C([H])([H])[C@]2([H])S(=O)(=O)OC1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])N=C(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C(=N2)C2=C([H])C([H])=NC([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C2=C(N([H])C(=N2)N2C([H])([H])C([H])([H])C3(OC(=O)C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C2=C1N=C(C([H])=C2[H])C([H])([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C(N([H])C3=NC4=C(C([H])=N3)N(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])N4C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N1C(=O)N(C([H])([H])C2=NC(=C([H])C([H])=C2[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C1N2C(=NC3=C1C(=C(O3)C([H])([H])[H])C([H])([H])[H])\C(=C(/[H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C2N=C(N([H])C2=NC([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1OC([H])([H])C([H])([H])[H]
[H]N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC([H])([H])[C@]1(OC(=O)\C(=C(\[H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C1([H])[H])C([H])([H])OC(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(=NO1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C([H])C(N([H])C(=N\C(=N[H])N([H])[H])\N([H])[H])=C([H])C([H])=C5N4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=NC([H])=C(O2)C([H])([H])C([H])([H])[H])S1
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C([H])=C4C([H])=C([H])C([H])=C(C4=N3)C([H])([H])[H])C([H])([H])[C@@]12O[H]
[H]N(C1=NN([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(C#N)C(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=C(N=C(N3C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])[H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C3C(=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H]
COC(=O)C1=CC=C(C=C1NC(=O)C1=CC=C2N=CC=CC2=C1)C1=CC=C(CN2CCC3=C(C2)C=C(OC)C(OC)=C3)C=C1
[H]\C(=C(\[H])[C@@]1([H])N(C(=O)[C@@]1([H])N1C(=O)OC([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C(OC([H])([H])[C@](O[H])(C([H])([H])[H])C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=NC(=C(S1)C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=N1
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(Cl)=C2C(=O)N(C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])[N+]([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])=C([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])=C2[H]
[H]N(C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)[C@@]2([H])OC3=C(C([H])=C([H])C([H])=C3N([H])S(=O)(=O)C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])C(F)(F)F
[H]OC1=C(C([H])=C([H])C([H])=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C([H])N=C([H])C([H])=C2N1[H]
[H]OC1=C([H])C([H])=C(\C([H])=N\N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(S1)C1=C2C(=NN1[H])C1=C([H])C(=C([H])C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC(=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H]
[H]N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N=C(O1)N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1)C([H])([H])[H]
[H]C1=NN=C(C([H])=C1[H])C([H])([H])C(=O)C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C1=C([H])N=C([H])C(=C1[H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C(I)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1\C([H])=C1\SC(=O)N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C#N
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C2=C1N([H])C1=C2C([H])=C(Cl)C([H])=C1[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC([H])=NC([H])=C1[H]
COC1=CC(=CC=C1)C(=O)NCCN1CCN(CC1)C1=NC=CC=C1C#N
[H]OC(=O)C(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C(C#N)=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C2=NSN=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C([H])([H])[C@@]12C(=O)C([H])([H])C([H])([H])[C@@]1([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]4(OC(=O)N(C([H])([H])C([H])([H])[C@@]([H])(OC(=O)C5([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])N5C([H])([H])C([H])([H])OC([H])([H])C5([H])[H])C4([H])[H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])=C1[H]
[H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C(OC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])=C([H])N=C1N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=NC(C#CC2=C([H])C(F)=C([H])C(C#N)=C2[H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(O[C@@]([H])(C#N)C([H])([H])[H])=C(C([H])=C1Cl)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C2N([H])C(=C([H])C2=C1[H])C1=C([H])C(=C([H])C(=C1[O-])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([O-])=O)C([H])([H])C([O-])=O
[H]N1C(=O)C2=C([H])C([H])=C([H])N2C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])N([H])C(=O)N1C([H])=C(C(=O)C2=C3N(C([H])=C2[H])[C@@]([H])(SC3([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C2=C([H])SC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]OC1(C([H])([H])N([H])C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C(F)=C(F)C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(SC(=C1[H])C1=NC(=NO1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)C(F)(F)F
[H]N([H])S(=O)(=O)N([H])[C@]1([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C1([H])[H]
C(CSC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1)CN1CCCCC1
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C3=C([H])C([H])=C([H])N=C3[H])C([H])([H])C([H])([H])C([H])([H])F)=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C([H])=C([H])C(=O)N([H])C1=C([H])N=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C(Cl)C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(\N=C2/SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@](OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H][C@]1(C[Se]SC[C@H](N)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)NCC(N)=O
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])[P@@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C(\C([H])=C(/[H])C4=C([H])C([H])=C([H])C([H])=N4)=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=NC(=NC([H])=C2C(F)(F)F)N([H])C2=C([H])N(N=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=N1)C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(OC([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
[H]N1C([H])=NC2=C1N=C(N1N=C(N=C21)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])SC1=NN([H])C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])=C([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=N\OC([H])([H])[H])\C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NN=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
Cc1cccc(c1)[C@@H](CO)NC(=O)c1cc(c[nH]1)-c1nc(N[C@@H]2CCOC2)ncc1C
[H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C([H])=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])S(=O)(=O)C2=C1[H]
[H]N1C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)=C(C#N)C(=O)C([H])([H])OC(=O)C([H])([H])SC1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(C([H])=C(Cl)C([H])=C2Cl)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C1([H])[H]
Cc1cnc(NCC(F)(F)F)nc1-c1cc(C(=O)N[C@H](CO)c2cccc(Cl)c2)n(C)c1
[H]N(C(=O)C1=C(C([H])=C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])S1
[H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Cl)=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C([H])C(SC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC4=C([H])C2=C(C([H])=C4[H])C([H])([H])[H])=C([H])C([H])=C3[H])=N1
[H]C1=C(N(C2=NC(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(I)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(OC2=C(C#N)C3=C(N=C(S3)C([H])([H])C(=O)C([H])([H])[H])C([H])=C2[H])=C1[H]
[H]C1=C([H])C(F)=C([H])C2=C1SN(C2=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@@](=O)(O[H])N([H])P(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N([H])C(=NC2=O)N([H])[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C3N(C(=O)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C3=C1[H]
[H]N1C(=O)N(C([H])([H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
FC1=CC=C(C=C1)C(=O)N1CCN(CC2=CC=C(C=C2)C2=NN=C3N2C2=CC=CN=C2NC2=C3C=CC=C2)CC1
CCC1=C(C=CC=C1CCCC(O)=O)C1=NC=CC(=N1)C1=CC=C(OC(C)C)C(=C1)C#N
[H]C1=C([H])C2=C(C([H])=C1[H])\C(=N\C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\N=C1/N3C(=NC4=C1C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N1C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(N=C1C([H])([H])[H])C([H])=C([H])C1=C2C([H])([H])C([H])([H])O1
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H]
[H]\C(=C(\C#N)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C(Br)C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C1=C2N=C(N=C2N([H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NN2C(=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
COC1=CC(C)=C(C(C)=C1)S(=O)(=O)N(C)CCOCC(=O)N1CCN(CC1)[C@@H]1CN2CCC1CC2
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1)[C@@]([H])(C(=O)N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N(C(=O)C1=C(OC(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C#N)C(=NC2=C1C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N=C(N=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C(F)C([H])=C1F)[C@@]1([H])C(C#N)=C(N(C(=C1C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N2N=NC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])C2([H])C3([H])C([H])([H])C([H])=C4C([H])([H])C([H])(O[H])C([H])([H])C([H])([H])C4(\C([H])=C(/[H])C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C12C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]ON(C([H])=O)[C@]([H])(C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N1C([H])=NC(=C1[H])C1(C2=C(C([H])=C([H])S2)C([H])([H])[H])C([H])([H])C1([H])[H]
CC1=CC=C(F)C=C1OC1=C(C(=O)N2CCNCC2)C2=CC(=CC=C2N1C1=CC=CC=C1)C(N)=O
[H]OC1=C2\C(=C(\[H])N3C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C([H])([H])C3([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C(=O)O[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1C(=O)OC1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1(C#N)C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C(C(=NN23)C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NOC(=C1C([H])([H])OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C([H])C3=C(O[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])O3)C([H])=C2[H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C([H])C([H])=C12
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C2C([H])=C([H])C(=NN12)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=NC(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1N=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)S2)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12
[H]OC(=O)C([H])([H])N1C(=O)C([H])([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])=C([H])C([H])=C2C1([H])[H]
[H]OC(=O)[C@@]1(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C(=O)N1[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])C2=NC([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C1=NN([H])C([H])=C1C1=C([H])N([H])C([H])=N1
[H]OP(=O)(O[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC1=NC([H])=C([H])N1C([H])([H])[C@]([H])(F)C1=C([H])C(OC2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C(=O)N1[C@@]2([H])C(=O)N3C([H])([H])C([H])([H])C4=C(C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C4[H])[C@]3([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(OC2=C([H])C([H])=C(O[H])C([H])=C2[H])C(Cl)=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(\[H])C2=C(C(=O)N([H])C(=O)N2[H])[N+]([O-])=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=S)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C3=C(OC4=C(C([H])=C([H])C([H])=C4[H])[C@]12[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C([H])([H])N(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])S3)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1=C([H])[C@@]2([H])C3=C(OC(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C([H])([H])C1([H])[H])C([H])=C(C([H])=C3OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)[C@@]1([H])C([H])([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C1=C(S2)C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(\C([H])=C2/N(C(=O)N([H])C2=O)C([H])([H])[H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O
[H]OC1=C([H])C([H])=C(C(=O)C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(=NC(=N1)N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])N([H])C1([H])C([H])([H])C1([H])[H]
[H]C1=NN(C(=C1[H])C1=NN(C([H])=C([H])C1=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C1=NN([H])C2=NC(OC3=C([H])C([H])=C(F)C([H])=C3F)=NC([H])=C12)[C@]([H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=NC(=N1)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C(C([H])=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]C#CC([H])([H])N(C([H])([H])[C@@]1([H])N2N(C(=O)C([H])=C([H])C2=O)C([H])([H])[C@]([H])(OC(=O)N([H])C2=C([H])C([H])=C([H])S2)[C@]1([H])OC(=O)N([H])C1=C([H])C([H])=C([H])S1)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[C@]1([H])C([H])([H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(N=C([H])C([H])=C3[H])N([H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])[C@]([H])(C2=C(F)C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
CCCCCC1=NN(C(=C1)C1=CC=C(Cl)C=C1)C1=CC=C(Cl)C=C1Cl
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C2=NC(Br)=C([H])S2)=C(N1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N1C(=O)N(C(=O)C1(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])SC([H])([H])[C@]1([H])C([H])(OC([H])([H])[H])OC([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1
[H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])[C@]1(O[C@@]2([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C([H])([H])N1C2=NC3=C(N2C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C2SN(C(=O)C2=C([H])C(=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C(Cl)=C(F)C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C2=NC([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C1(C(=O)N([H])N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])OC1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N1C(=O)C2=C(ON=C2C2=C1C([H])=C([H])C([H])=C2Cl)C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C(=O)C2=C([H])C([H])=C([H])S2)C(Cl)=C1Cl
[H]N1C(=NC(=O)C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC(=C(N1[H])C1=C([H])C2=NC([H])=C([H])N=C2C([H])=C1[H])C1=NC(=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=C3N(C(=O)[C@]([H])(N4C([H])([H])C([H])([H])N(C([H])([H])C5=C([H])C(Cl)=C([H])C([H])=C5OC([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3=C1[H]
[H]C#CC([H])([H])N([H])[C@@]1([H])C2=C(C([H])=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])F)C([H])([H])C([H])([H])C([H])([H])[C@]1(C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C2=C([H])C(C#N)=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@]2(C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC(=NN1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])C(OC2=C([H])C([H])=C3N([H])C(=NC3=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=[N+](C(=C(S1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])[C@@](N([H])[H])(C(=O)O[H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=NC([H])=C([H])S1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N1C(=O)N([H])C2=C(C1=O)C(=C([H])C(=O)O2)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]OC1=C(C([H])=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])OC5=C([H])C([H])=C6N=C(SC6=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H]
[H]OC(=O)[C@]1([H])N2C(=O)C([H])([H])[C@@]2([H])S(=O)(=O)[C@]1(\C([H])=C(\[H])C(=O)N([H])[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=NN=C4[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]O[P@@](=O)(C([H])([H])[H])[C@]([H])(C(=O)N([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])SC2=C1C([H])=C(Cl)C([H])=C2[H]
[H]O[C@@]1([H])O[C@@]2(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]O[C@@]12C([H])=C(C3=C4N([H])C5=C(C([H])=C([H])C([H])=C5OS(=O)(=O)C5=C(N=C(S5)N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C4=C([H])C([H])=N3)[C@]3([H])C([H])([H])C([H])([H])[N@](C([H])([H])[C@@]33C([H])([H])[C@@]4([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C4([H])[H])[C@@]13[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\C([H])=C([H])/C([H])([H])C2([H])[H]
[H]O\N=C(\N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N3C(=O)C([H])([H])N(C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[S@](=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C2C3=C(C([H])=C([H])N=C13)C1=C(N([H])[C@@]2([H])C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
CCCC1=CC(NC2=NC(NCC3=CC=CN=C3)=NC=C2Br)=NN1
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(SC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=NC(=NN1C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N([C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])N(N=C1C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]12C([H])([H])C([H])([H])C(=O)[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C(=C2Cl)C([H])([H])OC2=C3N=C(C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F
[H]OC(=O)[C@@]([H])(OC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=NC(=N1)N([H])[C@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H]
[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=C(C([H])=C([H])C(=O)N1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(C3=C([H])C(F)=C([H])C(=C3N2[C@]([H])(C2=C([H])C(F)=C(Cl)C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NC2=C(C([H])=C([H])C(OC3=C([H])C(=NC([H])=C3[H])C3=NC([H])=C(N3[H])C(F)(F)F)=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C([H])C([H])=C(F)C([H])=C23)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[P@@](=O)(O[H])[C@@]([H])(N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H][C@](N)(CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1B(O)O
[H]N1C([H])=C(N=C1C1=C([H])C([H])=C([H])N=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NC([H])=C([H])N(C1=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
FC1=C(F)C(F)=C(C(=O)C(=O)C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2Cl)C(F)=C1F
[H]N(C1=NC([H])=NC2=C1N=C(N=C2[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N1N=C([H])C2=C([H])C(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[C@@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C(F)=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(\C([H])=N\OC([H])([H])[H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C2N(N=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)O[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3C([H])([H])SC2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N1C2=C(SC3=C2C([H])=C(C([H])=C3[H])[N+]([O-])=O)C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N1C(=O)N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C1=NC([H])=C2C([H])=C([H])C(=O)N(C2=N1)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CC1=C(C=CC=C1CN1C=NC(=O)C2=C1N=C(S2)N1CCOCC1)C(F)(F)F
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C3C(=O)N([H])C([H])([H])C([H])([H])C3=C12
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C([H])C([H])=C23)C(=N1)C1=NC([H])=C([H])S1
[H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C(C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])[H])C(=N1)C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1F
[H]N(C(=O)C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=N3)C3=C([H])C([H])=C([H])C(F)=C3[H])[C@]3([H])[C@]([H])(OC(=O)[C@]3([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NC([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C2=C(N=C1[H])N(N=C2C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])[C@]([H])(OC(=O)[C@]([H])(N([H])C(=O)[C@]2([H])N=C(OC2([H])[H])[C@]1([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC([H])=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C(Cl)=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H]
OCCN1CCN(CC1)C1=NC(NC2=CC=CC(=C2)N(O)=O)=C2N=CNC2=N1
[H]C1=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C(=O)N1C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C2O[C@@]([H])(N([H])C2=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@]2(C([H])=C([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@](C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C2C(SC(C(=O)N([H])[H])=C2C2=C([H])C([H])=C([H])C(F)=C2[H])=C1[H])(C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)O[C@]2([H])C([H])([H])[C@@]([H])(C(=O)C([H])([H])[H])C([H])([H])[C@@]2([H])N([H])C(=O)C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H]
CC1=CC=C(C=C1)C1=CC=C(CCC(=O)N2CCC[C@H]2C2=NC=C(N2)C2=CC=CC=C2)C=C1
[H]OC([H])([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N(C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@]3([H])[C@@]4([H])C([H])([H])C([H])=C(C(=O)C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
NC1=NC=C(C=C1)C1=C2CCN(C2=NC(=N1)N1CCOCC1)C1=CC=NC=C1
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C#CC1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)C1=C([H])C2=C(S1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(Cl)=C([H])C(C(=O)N([H])C2=NC([H])=C(Cl)C([H])=C2[H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=NN1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(Br)=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
CC1=CC=CC(C)=C1C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1
ClC1=CC=C(C=C1)S(=O)(=O)N(CC1=CC=C(C=C1)N1CCCCC1)C1=CC=CC=C1
[H]N([H])C(=O)C1=C([H])C2=C(N1[H])C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1(C#CC2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])OC([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])C4=C3[C@@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]12C([H])([H])[H]
[H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C(F)C([H])=C1C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C(N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=C([H])C2=NC(=NC(=C12)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C([H])([H])C2=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3OC2=O)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(OC([H])([H])[H])C(C2=NC(=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC(=NC(=C1[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C(F)(F)F)C#N
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(C([H])=C(C2=C1[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])N=C([H])C([H])=C1N([H])[H]
[H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(C([H])=C4C(=O)OC([H])([H])C4=C3C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=NC(C2=C([H])N=C3C([H])=C([H])C(F)=C([H])N23)=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)C(=O)C1=NC(=NC2=C1SC([H])=C2[H])C(F)(F)F
[H]N(C(=O)C1([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])[C@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1N([H])C1=C(N([H])[C@@]([H])(C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])([H])C([H])([H])[H])C(=O)C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1
[H]OC(=O)C1=C([H])C([H])=C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C3([H])[H])N=C1[H]
[H]N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)C1=C([H])N=C([H])C(=N1)N([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N=C(N=C2N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])N([H])C([H])([H])C([H])([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@]3([H])[C@]([H])(C2=O)[C@]2(OC(=O)C([H])([H])[H])C([H])=C(C([H])([H])[H])[C@@]3([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(C([H])=C2C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C2N(N=C(C2=NC(=N1)C1=C(N([H])[H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C(C(=O)N([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C(Cl)=C1[H]
[H]OC1=C(Cl)C([H])=C(C([H])=C2C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2=O)C([H])=C1Cl
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N1N=C2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C2([H])[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])OC(=NN1C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])[N+](=C([H])C([H])=C1N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=O)C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C2=C(N([H])N=C2C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=C([H])C([H])=C([H])C2=O)C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NOC2=C([H])C([H])=C(C([H])=C12)N1N=C(C([H])=C1C(=O)N1C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C(Cl)=C([H])C2=NC2=C1[C@]1([H])C([H])([H])C(=C([H])[C@]([H])(C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]N1C2=NC(=C([H])C([H])=N2)C2=C([H])C(OC([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])N(C([H])([H])[H])C([H])([H])C3=C([H])C1=C([H])C([H])=C3[H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)N1C(=NC(C2=NN=C(O2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C1=C([H])C(=C([H])C([H])=C1[C@]1([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C(OC(=O)C([H])([H])C([H])([H])[H])=C1[H])C(F)(F)F)C(F)(F)F
[H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=NC([H])=C2S1
[H]N([H])C1=C([H])C2=NC([H])=NC([H])=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[P@](=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H]
[H]OC(=O)C1=C(OC2=C([H])C([H])=C(F)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=NC([H])=C([H])N=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=NC([H])=NC(=C2[H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@]([H])(F)[C@]([H])(C([H])([H])N(C(=O)N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])[C@@]([H])(C2=NC(=NN2C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C2=C(F)C([H])=C([H])C(F)=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])C1=C([H])[C@@]2([H])[C@@]3([H])[C@@](OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])([C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])[C@]2([H])C([H])=C(C(=O)[C@@]2([H])C1([H])[H])C([H])([H])[H])C3(C([H])([H])[H])C([H])([H])[H]
CN(C)C1=CC=C(C=C1)N1C=C(CN2C=CC=C(O)C2=S)N=N1
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2([H])C3=C([H])C([H])=C([H])C([H])=C3OC3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C(=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[C@]1([H])[C@]2([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C(=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C(O[H])=C1[H])[C@@]1([H])OC2=C(C(O[H])=C([H])C(OC([H])([H])[H])=C2C(=O)C1([H])[H])C([H])([H])[C@@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C2=O
[H]N([H])C1=C([H])C(OC([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=S)N(C2=NC(=C([H])S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=O)C1([H])[H]
[H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C(=C2[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
CC(C)(C[C@@](O)(CC1=CC2=CN=CC=C2N1)C(F)(F)F)C1=CC(F)=CC=C1O
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])=C([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])[C@]1(OC([H])([H])[H])C(=O)N2C(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])([H])SC3=NN=NN3C([H])([H])[H])C([H])([H])O[C@]12[H]
[H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#C[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N=C(C(C(=O)N([H])[H])=C1N2[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])S(=O)(=O)N([H])C1=C2N=C([H])C([H])=C([H])C2=C([H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C(=NC1([H])[H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(\N=C1\C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C(C#N)C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])C([H])([H])C([H])([H])[C@@]21C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C1=O
[H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(F)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2N([H])C2=NC([H])=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=NN(C2=C1[H])C([H])([H])C([H])([H])N([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C#N)C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C(F)(F)F
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C2C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(F)=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])N([H])C2([H])[H])C(F)=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(N([H])C(=O)N([H])C1=O)C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C(N([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])N=C2C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(C([H])=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])\N([H])[N+]([O-])=O
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])[C@]([H])(O[H])[C@@]([H])(N([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(\[H])=C(/[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=NC(=N2)N([H])[H])N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])[H]
[H]C([H])([H])C([H])([H])C([H])([H])SC1=NSN=C1O[C@@]1([H])C([H])([H])[N@@]2C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C2N=C(C([H])=C([H])C2=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C#N)C1(C([H])([H])OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CN(C)CC[C@H](CSC1=CC=CC=C1)NC1=C(C=C(C=C1)S(=O)(=O)NC1=NS(=O)(=O)C2=C1C=CC(=C2)N1CCN(CC2=C(C=CC=C2)C2=CC=C(Cl)C=C2)CC1)[N+]([O-])=O
[H]N(C([H])=O)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1C1=C([H])C(F)=C(F)C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2N(C(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C3=C(C(=NN3C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NN=C([H])S1
[H]N(C(=O)C1=C([H])C(F)=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C2=NC(=C(C(=N2)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=NC2=C(C([H])=C(C([H])=C2N1[H])C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])[H]
[H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])[C@@]1(O[H])C([H])([H])[H])C([H])([H])OC(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C1C(=O)O[C@]2([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]3([H])C([H])=C([H])C(=O)[C@@]3(C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]12[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N(N=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C(I)=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=S)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=NN(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C1=C2C(SC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC2=C1N=C([H])C([H])=C2N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC([H])=C([H])N1C([H])([H])C(C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
CCN(C)C(=O)C1=CC=C2N=C(NC(=O)C3=CC=CC(=C3)C#N)N(CCCOC)C2=N1
[H]N(C1=C(C(OC2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=NC([H])=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(N=C1C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C(=NC([H])=N2)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]N1N=C(C(=C1N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C2=NC(=NC3=NC([H])=C([H])N=C23)C2=C(F)C([H])=C([H])C(Br)=C2[H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)C(=O)N([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1Cl
[H]N(C1=C2C([H])=C(N([H])C([H])([H])[H])C([H])=C([H])C2=NC([H])=N1)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
OC(CNC1CCN(CC1)C1=NC=NC2=C1C(=CS2)C1=CC=CC=C1)COC1=CC=CC(=C1)C(=O)N1CCOCC1
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C(=O)C1([H])[H])C2([H])[H]
[H]OC([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=NC(OC([H])([H])C([H])([H])[H])=C(C#N)C(N([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])OC1=C([H])C(N([H])C2=C([H])N=C([H])C(=N2)C2=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N2C([H])=NC([H])=C12)C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12[H]
[H]OC(=O)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(=C([H])C([H])=C12)C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=NC(C2=NN=C(O2)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=NC([H])=C2C([H])([H])C(=O)C2=C(N([H])[H])C([H])=C(F)C(=N2)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2F)C([H])([H])[C@@]1([H])N([H])[H]
[H]N(\N=C(/[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3C2=O)C2=C(N1[H])C([H])=C([H])C(=C2[H])C([H])([H])[H]
[H]N1C(=NC2=C1C(=O)N(C1=NC3(C([H])([H])N21)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@](C(=O)N([H])C1=C([H])C([H])=C(C#N)C(=C1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])SC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])Cl)C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1N([C@]([H])(C([H])([H])[H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N=C(N([H])[H])N([H])S(=O)(=O)C1=C([H])C(N([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=N1)C(C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])N([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1[N+]([O-])=C([H])C([H])=C2[H]
[H]C1=C2C3=C(C([H])=C([H])C([H])=C3N1C([H])([H])[H])C(=O)N(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N(C1=NC(OC([H])([H])C([H])([H])[H])=NC(=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C([H])=NC2=C3C(=O)N(C(=O)N(C3=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2Cl)[C@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1SC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)OC(C2=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1(O[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]C([H])=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C([H])C(=N1)C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=NC3=C([H])C([H])=C([H])C([H])=C3N=C21)C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@@]2([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)[N+]([O-])=O)C(=O)[C@]1([H])OC2=C(OC1([H])[H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(Cl)C([H])=C([H])C(OC([H])([H])[H])=N1)C1=C2C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C([H])C2=NC([H])=N1
[H]C1=C([H])N=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N1N=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C(=C2[H])[C@]2([H])C([H])([H])[C@]3([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C(=O)C([H])([H])C([H])([H])[H])C(=C1OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1([H])C([H])([H])C([H])(O\N=C2/C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C3([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[O-][N+](=O)C1=CC2=C(NC3=NNC(CCC4=CC=CC=C4)=C3N=C2C2=CC=CC=C2Cl)C=C1
[H]OC([H])([H])C([H])([H])C1=C2N=C([H])N=C(N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C3[H])C2=C([H])C(N(C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])=C1OC([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]2([H])C(=O)N(C(=O)[C@@]12[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
FC(F)(F)OC1=CC=C(NC2=NC=NC(=C2)C2=CC=CC(=C2)C(=O)NCCN2CCOCC2)C=C1
[H]ON([H])C(=O)[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(O1)C([H])([H])[H]
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1=NC3=C([H])C([H])=C(F)C([H])=C3C(C([O-])=O)=C1C([H])([H])C2([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@](C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])([H])OC1=O
[H]C1=C([H])C([H])=C(C(=C1[H])C1=NC2=C(C3=C(S2)C([H])([H])C([H])([H])C3([H])[H])C(=O)O1)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(Br)=C(N([H])SC(=S)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])\N=C(/[H])C1=C2C([H])=C([H])N(C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
CCC1=C(C=CC=C1CCCC(O)=O)C1=CC=C(N=N1)C1=CC=C(OC(C)C)C(=C1)C#N
[H]C1=C([H])C(=C([H])S1)N1C([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(N([H])C(=O)N(C4=O)C([H])([H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C(N([H])C(=N2)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN=C(S1)C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=NN1C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
CC(C)NC1=C2C=CC(=CC2=NC=C1C#N)C1=CN=C(C)S1
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N=N2)C2=C([H])C([H])=C([H])O2)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)N([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=NN([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])[S@@](=O)C([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@]1([H])C(=O)[C@]2([H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]3(OC2(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]13C([H])([H])OC(=O)C([H])([H])[H]
[H]O[C@]([H])(C(\[H])=C(/[H])C1=C2C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O
[H]OC1=C([H])C(=C([H])C(O[H])=C1C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NN2C([H])=C([H])C([H])=NC2=C1C1=NC([H])=NC(=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])C1([H])[H]
[H]N=C(N([H])C1=C(Cl)C(=C([H])C(Cl)=C1[H])C(F)(F)F)N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(=N/C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])N(C2=C(OC([H])([H])[H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H])C1=NN=NN1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=O)C(=O)C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])O[H])C([H])([H])[H]
[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C2N([H])C(=O)C([H])([H])N(C2=NC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
CS(=O)(=O)NC1=CC=C2N=C(CN3CCC(CC4=CC=C(I)C=C4)CC3)NC2=C1
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C([H])([H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C(F)C([H])=C1F
[H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(O[H])=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C(OC([H])([H])[H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])C1=C(C2=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])N([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=NC(=C([H])S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC3=C(N=NN3C3=C2SC([H])=C3[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(N1[H])[S@](=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CC(C)OC1=CC=C(C=C1Cl)C1=NC(=NO1)C1=CC=C2NC(CCC(O)=O)=CC2=C1
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(OC2=NC(=NC(=C2[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])=C1[H]
CC(=S)NCCC1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O
[H]C1=NC(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=C2C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[C@@]([H])(N1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])=O
[H]O[C@@](C(=O)O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(I)C([H])=C1[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C(F)=C2OC1([H])[H]
[H]C1=C([H])C(=C([H])S1)[C@]1([H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])N(C(=O)C1=C([H])C(=NN1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]C1=C([H])N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=C([H])C(F)=C1[H])C1(SC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=NC2=C1N=C(S2)C1=C(N=C([H])N1C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@](C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C(OC([H])(F)F)C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]N1C(\C([H])=C2/C(=O)N(OC(=O)C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])[C@]2(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([O-])=O)=[N+]([H])[H]
[H]C1=C([H])C(Cl)=C([H])C2=C1C([H])([H])N(C(=O)C1=C([H])C(=C([H])C([H])=C1O[C@@]([H])(C([H])([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C2([H])[H]
[H]N(OC([H])([H])[H])C(=N/C1=C([H])C([H])=C(C2=C([H])N=C([H])O2)C(OC([H])([H])[H])=C1[H])\N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])[C@@]([H])(OC1=C(C#N)C([H])=C([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=NO1
[H]N(\C(=N/C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])S2)[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSC1([H])[H]
[H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@]3(O[H])C([H])([H])C4=C(C([H])=C(O[H])C(O[H])=C4[H])[C@]23[H])=C1O[H]
[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)S1)C(=O)N([H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C(C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C(N(C(=O)C([H])([H])OC(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C(ON=C3C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(N([H])C3=NC([H])=NC4=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C34)C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C(N=NN1[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H]
[H]N([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C2=N[N-]N=N2)(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(SN=C2C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
O=C(N1CCCCC1)C1=C2NC=C(CN3CCN(CC3)C3CCC3)C2=CC=C1
[H]N=C1N2N=C(SC2=NC(=O)\C1=C(/[H])C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]S\C(=N/N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H]
[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=N1)C([H])=C(Cl)C([H])=C2[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C3=C([H])C([H])=C([H])C(=O)N3C([H])([H])[C@]([H])(C1([H])[H])C2([H])[H]
[H]OC(C#C[C@@]1(OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])SC([H])=C1[H])C1=C([H])SC([H])=C1[H]
[H]N([H])S(=O)(=O)N([H])C([H])([H])C1=C([H])SC2=C1C(Br)=C([H])C([H])=C2[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C1=NOC(=N1)C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C(C3=C(C([H])=C(OC([H])([H])C([H])([H])[C@@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C1([H])[H]
CN(C)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(C=C1[N+]([O-])=O)S(=O)(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=CC(=CC=C1)C1=C(N(C)C(C)=C1C(F)(F)F)C1=CC=C(Cl)C=C1
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C(C2=C(N([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])C1=C2C([H])=C(SC2=NC([H])=C1C#N)C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]N([H])C(=N/OC(=O)N1C2=C([H])C([H])=C([H])C([H])=C2SC2=C([H])C([H])=C([H])C([H])=C12)\C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C1=C(C2=C(N(C1=O)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C(OC2=C(N=C(N=C12)C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])S1)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(N=C(N3C([H])([H])[H])C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N2C(=NC3=C([H])C(=C(C([H])=C3C2=O)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C2N=C(N(C2=C1[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(F)F)C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
CNC1=NC(C)=C(S1)C1=NC(NC2=CC(=CC=C2)C(=O)N2CCOCC2)=NC=C1C#N
[H]N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])[C@@]1([H])N([H])[C@]2([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)N=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C(=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=C(N=N1)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1\C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C([H])C(C#N)=C([H])C(=C3O2)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C(C([H])=N1)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])\N=C2/C(=O)N([H])C3=C2C([H])=C(C([H])=C3[H])S(=O)(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C([H])\C1=N\C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@]([H])(N2C(=O)C3=C([H])C(OC4=C(F)C([H])=C(F)C([H])=C4[H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC1=C(C(=C2O[C@](C([H])([H])[H])(C([H])([H])OC([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C([H])([H])C([H])([H])C2=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C#N)=C(I)C([H])=C1N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@@]1(O[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC2=C3C([H])=C([H])N([H])C3=NC([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C1([H])C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N(C([H])([H])[H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])C([H])(C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(O[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])O[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
CC(=O)N[C@@H]1C[C@H]1C1=CC=CC2=CC=CC=C12
[H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NOC3=C2C([H])([H])C2=C([H])C(O[H])=C([H])C([H])=C32)C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2[C@]([H])(C([H])([H])[H])C([H])([H])[C@]3([H])F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(=NN1[H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C(S1)C1=NN=C2S\C(=C(\[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=NN12)C1=C([H])C(F)=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N(C1=NC(=C([H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C(N=C(S2)N2C3=C(OC([H])([H])C2([H])[H])C([H])=C([H])C(=C3[H])C(=O)C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C(N(N=C1C([H])([H])[H])C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2C#N)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=NN(C([H])=N1)[C@]([H])(C1=C([H])C2=C(O1)C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])S2)C2=NOC(=N2)C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])[H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])O[C@@]([H])(C1=C(F)C([H])=C([H])C(Cl)=C1[H])[C@@]1([H])C([H])([H])N(C(=O)N([H])[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(C(=NN2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(Cl)=C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C3=NN2C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC3(C(=O)N([H])C(=O)N([H])C3=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=N1
[H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C3C(C([H])=C([H])C([H])=C3C3=C([H])C([H])=C([H])C([H])=C3C2=O)=C1[H]
[H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C(=C([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=C1Cl)N1N=NN=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NC([H])([H])C([H])([H])C([H])([H])N1[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(C2=NC([H])=NC(N([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])O[P@@](=O)(O[H])C([H])([H])P(=O)(O[H])O[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C(C([H])=C3[H])N3C(=O)C4=C(C(=NN4C4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(OC3=NC([H])=C(Cl)C([H])=C23)C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H]
[H]N(C1=NC(Cl)=C([H])N(C1=O)C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C(C([H])=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N2C([H])=C([H])N=C2C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N(C(=O)C(=C(C#N)C#N)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H]
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N[C@@H]1CC[Se]C1
[H]C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)C1=NOC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=NC(=C([H])S1)C1=C([H])C(N([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])=C([H])C(Br)=N1
[H]C1=C(SC2=C1N=C(N=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(O[H])C(Cl)=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1([H])C([H])([H])N(C#N)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=C(N=C2N1C([H])([H])C([H])([H])C(=O)N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(OC([H])([H])[H])C(=C([H])C(OC([H])([H])[H])=C1Br)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C(=O)N([H])C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])[H])[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C(=O)N(C1=C(C([H])([H])[H])C([H])([H])[C@@]([H])(N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N(C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(Cl)C([H])=C([H])C([H])=C12
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@]2(OC(=O)C2=C([H])C([H])=C([H])O2)C(=O)C([H])([H])SC2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(OC([H])([H])[H])OC([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C(=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])[C@]1([H])C([H])([H])C(F)(F)C([H])([H])C([H])([H])[C@]1([H])N([H])[H])N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])(C(F)(F)F)C(F)(F)F)=C(N([H])[H])C(F)=C1[H]
[H]N(C(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C3=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C(Cl)=NC([H])=N2
[H]O[C@@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])[C@]2([H])OC([H])([H])C([H])([H])N(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
CCCCN1C=C(CC(=O)NC23CC4CC(CC(C4)C2)C3)C2=CC(=CC=C12)C1=CC=CC=C1
[H]O[C@@]1([H])[C@@]([H])(O[C@@]([H])(O[C@]2([H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@](OC([H])([H])[H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@]4([H])N(\C(O[C@@]34[H])=N\C([H])([H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])[H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1(OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3F)C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=NN(C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N=C(S2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=NON=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C3=NON=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(Cl)C3=C(C([H])=C2[H])C(=C([H])C(=O)O3)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(O[C@@]([H])(O[H])C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[C@@]3([H])SC(=O)N([H])C3=O)C([H])([H])C2([H])[H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=NC(OC2=C([H])C(Cl)=C(N([H])C(=O)N([H])C3=C([H])N=C([H])C([H])=C3[H])C([H])=C2[H])=C1\C([H])=N\OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])N2C(=O)C(=C3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)OC2=C([H])C([H])=C([H])C([H])=C12)C1=NC(=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@@]13O[C@]4(O[C@@]([H])([C@]1([H])C([H])=C(C([H])([H])OC(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(N([H])[H])C(Br)=C1[H])C2([H])[H])[C@@](O4)(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)C1=C(O[H])C2=C(C([H])=C([H])C(=C2[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N(C1=O)C([H])([H])[H]
ClC1=CC=C(C=C1)C1=CC=C(NC(=O)CCCCN2CCCCC2)C=C1
[H]N([H])C1=C(C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C#CC1=C([H])N([H])C([H])=N1
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]O[C@]1([H])C([H])([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])O[H]
[H]N(C(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])[C@]2([H])N(C3=NC(C#N)=C([H])C([H])=C3C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[C@]3([H])C([H])([H])[C@]3(C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC([H])=NC(=C2[H])C2=C(F)C([H])=C(F)C(F)=C2[H])C([H])([H])[C@]1([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
CCC1=NC2=C(N1[C@H]1CCC3=C1C=CC(=C3)C1=CC=CC=C1C1=NN=NN1)C(=O)N(CC(O)=O)C=C2
[H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=S)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C([H])C([H])=NN3C(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[H])[C@]([H])(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(N1C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2C1([H])[H])C1=NC([H])([H])C([H])([H])N1[H]
[H]\C(=C(/C1=C([H])C([H])=C(C([H])=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])N=C12)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])C(=O)[N-]S1(=O)=O)S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(Br)=C([H])C(Br)=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1N=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])=C1[H]
[H]N(C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NC([H])=C(C(=N1)N([H])[C@]1([H])[C@@]2([H])C([H])=C([H])[C@]([H])(C2([H])[H])[C@]1([H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C([H])O1
[H]OC(=O)[C@@]([H])(O[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N([H])C(=O)[C@@]1([H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])=C([H])C([H])=C2[H]
[H]N(\N=C(/C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=NC3=C([H])C([H])=C(O[H])C([H])=C3O[C@]1([H])C2([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]ON(C(=O)N([H])[H])[C@]([H])(C1=C([H])C2=C(S1)C([H])=C([H])C([H])=N2)C([H])([H])[H]
[H]ON(C([H])=O)[C@]([H])(C([H])=C1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(F)C(OC([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C(F)C(F)=C1[N+]([O-])=O
[H]C1=C([H])C(I)=C(C([H])=C1[H])C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H]
[H]N1C(SC([H])([H])C2=C(OC([H])(F)F)C([H])=C([H])C(Cl)=C2[H])=NC(=O)C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C2=NN([H])N=N2)C(=NC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC3=C(N([H])C(=O)N3C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=N2)C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(Cl)C(Cl)=C2C([H])([H])N1[H]
[H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC(=N3)N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C2=C([H])C(=NN2C2=C([H])C([H])=C([H])C([H])=C2C1=O)C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(C([H])=C1[H])[C@@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1O[C@@]([H])(C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C(O[C@@]2([H])C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C2=C(S1)C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C(=O)OC([H])([H])[C@]([H])(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(Cl)=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
COC1=CC=C(NC2=C(C(C)=NN2C2=C(C)C=CC=C2)C2=CC=C(C)C=C2)C(=C1)C(O)=O
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=N3)C([H])=C(Cl)C([H])=C2Cl)C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)N([H])C1=C(F)C(F)=C(F)C(F)=C1F
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2O[C@@]([H])(C([H])([H])[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C(=O)C([H])([H])Br)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])[C@@]2(O1)C([H])([H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C(C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C4=NN=C(O4)C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C(Cl)C([H])=C2C(=O)C3=C(N(N=C3C([H])([H])[H])C([H])([H])[H])N(OC([H])([H])C([H])([H])[H])C2=C1[H]
[H]N(N([H])C(=O)C1=C([H])C(F)=C([H])C(=C1[H])C(F)(F)F)C(=O)N([H])[C@@]([H])(C1=NC([H])=C(C([H])=C1F)C(=O)N1[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])N2N=C([H])C3=C(SC(=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
COC1=CC=C(C=C1)N1N=C2N(C1=O)C1=C(C=CC=C1)N=C2NC(=O)CCC(=O)NCCOCCOCCN
[H]N1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(C([H])=C4OC([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C([H])([H])C1=O
[H]N1C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H]
[H][C@@]1(C2=CC=CC(=C2)[N+]([O-])=O)C(C(=O)OC)=C(C)NC(C)=C1C(=O)OCCCN1CCC(CC1)(C1=CC=CC=C1)C1=CC=CC=C1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C12)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=C([H])N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)[C@@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC(=C2C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(SC([H])=C2[H])C(=N1)N1C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C([H])C2=C(N([H])C(=C2[H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C([H])=C3F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1N2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]1(C2=NC(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(=NC(C#N)=C([H])C3=C2[H])C2=C([H])OC([H])=C2[H])C([H])([H])[C@]2([H])OC([H])([H])[C@@]([H])(O2)C1([H])[H]
[H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(N=C(N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(N=C(N=C1N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C#N)N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1(C([H])([H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(S1)C(\[H])=C1/OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C2N=C(C(=C([H])N2N=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC2=C(OC3=NC([H])=NC(=C3[H])C3=C(N([H])C(=O)[C@@]4([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2S1
[H]N=C(N([H])[H])N([H])C1=NC([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC([H])=C(O1)C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(O[11C]([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2N([H])C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])=C(SC([H])([H])[H])C(=C1[H])N(C1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H]
[H]OC1=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])([H])C(=O)N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C32)=C([H])C([H])=C1OC([H])([H])[H]
[H]N1C2=C(C([H])=C(Cl)C([H])=C2[H])[C@@]2(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3[H])[C@@]22C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C1=O
[H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C(C([H])=C(Cl)C([H])=C1[H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])=C2[H]
[H]C1=C([H])C([H])=C2C(=C1[H])[C@]1(OC(=O)C([H])([H])[H])C3=C(C([H])=C([H])C(OC(=O)C([H])([H])[H])=C3[H])[C@]21C1=C([H])C([H])=C(OC(=O)C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=NC2=C(SC([H])=C2[H])C1=O
[H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C(F)(F)F
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C2(C1=O)C([H])([H])C2([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]O[C@@](C1=C([H])C(Cl)=C([H])C([H])=C1[H])(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)N([H])[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=NOC(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)C([H])([H])O2)C([H])([H])C#CC1=C([H])C2=C(C([H])=C1[H])N1C(=NN=C1C([H])([H])N=C2C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C2O[C@]3([H])OC([H])([H])C([H])([H])[C@@]3(C2=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H][C@@]12C[C@H](OC(=O)C3=CC=C(Br)C=C3F)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1
[H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1)C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2S1
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C(OC([H])([H])[H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C(Cl)C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N1)C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=NN=C(S1)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C(S1)[C@]1([H])OC2=C(N=NC(SC([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[P@@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(F)N=C1[H])C1=C([H])N2C(=NC(=C2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
CC(=O)N[C@@H](CC1=CC(F)=CC(F)=C1)[C@H](O)CNC1(CCCCC1)C1=CN(CC(C)(C)C)N=C1
[H]O[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=NC(=C1[H])C([H])([H])S[C@]1([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]1([H])OC(=O)C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(N=C23)C#CC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])N([H])OC([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])[N+]([O-])=O
[H]N([H])C(=O)C1=[N+]([O-])C2=C([H])C(=C([H])C(=C2S1)[N+]([O-])=O)C(F)(F)F
[H]C1=NC2=C([H])C([H])=C(OC3=NC4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])=C2S1
[H]C1=C([H])C([H])=C(O1)C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=NC(OC([H])([H])[H])=C([H])C([H])=C1N1C(=NN=C1C([H])([H])OC([H])([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])OP(=O)(N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C1=NC2=C(C(=NN2C2=C(Cl)C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C([H])([H])[H])C(=O)N1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(F)=C([H])C([H])=C2[H])[C@]1([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])C(=O)N(C2=C([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]2(C(=O)OC([H])([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]OC1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C(S1)N1C(=NC([H])=C1C([H])([H])[H])C(=N2)N([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1OC([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C(S2)C2=NC([H])=C(S2)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=NC([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C12)C1=C([H])C(=C([H])C([H])=C1[H])C1=NC([H])=C([H])S1
[H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(N=C(N=C12)C#N)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C23)C([H])([H])C1([H])[H]
C[N]1=C2C=CC(=CN2C=C1C1=CC=CC=C1)C(N)=O
[H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)O[H]
[H]N(C1=NC([H])=C(N2C([H])=NC([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])N=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
OC(=O)[C@H]1CC[C@@H](CC1)OC[C@@H]1C[C@H](F)CN1C(=O)CC1=CC2=C(C=C1)N=C(O2)C1=C2C=CC=CC2=NC=C1
[H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]C1=C([H])C(C2=NC(=C3N2C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2N=C3C([H])([H])[H])C([H])([H])[H])=C(C([H])=N1)C([H])([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1N=C(C2=C(N=C(N=C12)C([H])([H])[H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])SN=N1
[H]\C(=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C(F)=C([H])C([H])=C2O1
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COCCCC1CCCN1S(=O)(=O)C1=CC=C2NC(=O)C(=O)C2=C1
[H]N=C(SC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)N([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N1N([H])\C(C([H])=C1C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])=C1/C([H])=C(F)C([H])=C([H])C1=O
[H]N(C(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N1N=NC(=N1)C([H])([H])N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C(O[H])C([H])=C(O[H])C([H])=C1O[C@]1([H])O[C@@]([H])(C([H])([H])O[H])[C@]([H])(O[H])[C@@]([H])(O[H])C1([H])[H]
[H]C1=NN(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])OC2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C(\C([H])=C2/C(=O)N([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)=C1C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])N=C1[H])C1=C([H])N=C(S1)N([H])C1=C(Cl)C([H])=C([H])C([H])=N1
[H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C(\[H])=C(\C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C2C([H])=NN(C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@]1(OC(=O)\C(O1)=C(\[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])OC2(O[C@@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])=C([H])C(=O)C([H])=C2[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C21C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@]12C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@]1([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=S)C2(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]ON(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C(=C([H])S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C2=NC([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C([H])=NN12
[H]N(C(=O)N1C(=O)C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])SC2=NC3=C(C4=C(S3)C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C(=O)N2C([H])([H])C([H])=C([H])[H])C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(C2=C([H])C3=NC(N([H])[H])=C([H])C([H])=C3N2[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(O[H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=NN(C1=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]1(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2OC1([H])[H]
[H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]1([H])C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@@]1([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[N@]2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])[C@]([H])(C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C2=NC([H])=C([H])C([H])=C12)C1=C(C2=NC([H])=C([H])S2)C(Br)=C([H])S1
FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=CSC=C1
[H]C1=C2OC([H])([H])C([H])([H])OC2=C([H])C2=C([H])C(C#N)=C(SC([H])([H])C(=O)C([H])([H])[H])N=C12
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C(F)=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=NC2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C(C([H])=C([H])C([H])=C4[H])C(=O)N([H])C4=C([H])C([H])=C5N=C(C([H])=C(N([H])[H])C5=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])=C12)C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N(C([H])([H])C1=NC(=NS1)C1=C([H])N(C2=C(Cl)C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C1=NC([H])=NC2=C1C(=C(O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(O[H])=C1[H])[C@]1([H])OC(=O)C2=C1C(O[H])=C([H])C([H])=C2[H]
[H]N1C([H])([H])[C@]([H])(N(C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(SC(=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C([H])N=C2[H])C([H])([H])[H])C(=O)C1=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C12
[H]OC1=C([H])C(Br)=C(C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C(=S)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H]
[H]OC(=O)C1=C([H])C(Br)=C([H])C2=C1OC(=C(OC([H])([H])C([H])([H])C([H])([H])[H])C2=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])=O
[H]N(C(=O)C([H])([H])OC([H])([H])C([H])([H])C([H])([H])OC1=NSN=C1C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@]1([H])O[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(\C(\[H])=C(/[H])C3=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H])/C([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]OC1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])[H])S(=O)(=O)OC1=C([H])C([H])=C(\C([H])=C(/[H])[N+]([O-])=O)C([H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=NOC(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C#N)C2=C(S1)C([H])([H])[C@]([H])(N(C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C1=C2C([H])([H])[C@@]([H])(C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C(Cl)C(=C2[H])C(=O)N2C([H])([H])C3=C([H])N=C(N3C([H])([H])C2([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1N([H])[H])C(F)(F)F)C([H])([H])N([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C2N1[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC(=O)[C@@](S1)(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N([H])C(=N/OC(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)\C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1OC([H])([H])O2
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)OC2=C1C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3F)=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(SC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C(C#N)C(C#N)=C1SC1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N=C(N2C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C3=NC4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C2=C1N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C21
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C(F)C(F)=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(C(=O)N([H])C([H])([H])[H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C([H])C([H])=C([H])C2=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C#N)C(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C2N=C([H])C3=C(N(C(=O)C([H])=C3[H])C3=C([H])C(=C(F)C([H])=C3[H])C(F)(F)F)C2=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C(O[H])C([H])=C3O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C([H])([H])C3=O)C([H])=C1[H])C([H])([H])C([H])([H])O2
[H]N1C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(Cl)=C4Cl)C([H])([H])C3([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C#N)(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(\N=N\C(=O)C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC([H])=C([H])C([H])=C4F)C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C(C(=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])=NN(C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
CN1C(=O)C(CC2=CC=C(F)C=C2F)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12
[H]OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])[C@]1([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2N([H])C(=O)C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C(=C([H])C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])=C1N2C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N=C(N([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=C([H])N3C([H])=C(C([H])=C([H])C3=N2)C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N(C1=NC([H])=C2N(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])N(C2=N1)C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])OC([H])([H])C([H])([H])N(C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
CS(=O)(=O)C1=CC(F)=CC=C1N1CCN(CC1)C(=O)[C@H](NC(=O)C1=CC=C2C=CN=C(N)C2=C1)C1=CC=CC=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H]
[H]N(C1=NC([H])=C2N(C(=O)N(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(=O)[C@@]1([H])N(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C3=C([H])C([H])=C([H])C(OC4=C([H])C([H])=C([H])C([H])=C4[H])=C3[H])C([H])([H])C2([H])[H])C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C#N)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])N1[H]
[H]O\N=C(\C1=C([H])N2C3=C1C([H])=C([H])C([H])=C3C(=O)N([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])N2N=C(N=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C1C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C(C([H])=C([H])C([H])=C2[H])C(O[H])=C1N=O
[H]N([H])C1=NC2=C(C(=N1)N([H])[H])C(=C(C([H])=N2)C([H])([H])N1C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C(\[H])=C(\[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1O[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(OC1=C([H])C([H])=C(F)C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]1([H])C([H])([H])[C@](C1=NN=NN1[H])(C3([H])[H])C2([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])N1C2=C(C([H])=C([H])C(=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=NC(=C([H])N2[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H]
[H]C#CC([H])([H])N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])S(=O)(=O)C1=NN(\C(S1)=N/C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)[C@]1([H])C2=C(OC3=C1C([H])=C([H])C(F)=C3[H])C([H])=C([H])C([H])=C2[H])C1=NC(=C([H])O1)C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H]
[H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C2=C(N([H])C(=N2)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N(C#N)C(=N/C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])\N([H])C1=C([H])C([H])=C(C2=C([H])N=C([H])O2)C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@]([H])(O[C@@]2([H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]([H])(O[C@]2([H])C([H])([H])O[H])N2N=NC(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(=C(/[H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C3=NN(N=N3)C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H])C([H])([H])O[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C(C2=NC([H])=C([H])N2C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C([H])C3=C(N2N=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C3([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C3C([H])=C([H])C([H])=NC3=C([H])C([H])=C2[H])=N1
[H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N2C(=NC3=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C2=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])[C@@](C#N)(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C(F)=C(F)C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(C#CC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]\C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])=C1\C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C([H])([H])C3([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=C(S1)C([H])([H])N(C1=NC([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N(C(=O)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C(=NC([H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C1=C([H])SC2=C([H])C([H])=C(F)C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3OC([H])([H])OC3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C([H])C(=N1)C1=C(N=C([H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(C([H])=C([H])C(OC2=C([H])C([H])=C(F)C([H])=C2[H])=N1)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C2=C(OC(=N2)C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NSN=C23)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC2=NC([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=C1[H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C#N)C2=C(S1)N(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2[H])[C@@]1([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C(F)S1)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=C([H])[H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(F)=C(F)C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C(F)=C([H])C([H])=C2[H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])[C@]2([H])OC3=C(O[C@]2([H])C1([H])[H])C(F)=C([H])C([H])=C3[H]
[H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=C([H])C(=N2)N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C2[H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]2(C([H])([H])OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]3([H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]12OC3(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C2=NC([H])=C(Br)C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2N=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H]
[H]OC1=NC(=C(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C1=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])OC3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])[H]
[H]N(C(=O)OC1=C([H])C2=C(N([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]23C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C([H])([H])C1=C(N=C([H])S1)C([H])([H])[H])C2([H])[H]
[H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1=C([H])SC([H])=C1[H])C(=O)N([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H]
CC(C)C1NC(=O)C(C)OC(=O)C(NC(=O)C(OC(=O)C(NC(=O)C(C)OC(=O)C(NC(=O)C(OC(=O)C(NC(=O)C(C)OC(=O)C(NC(=O)C(OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
[H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)O[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H]O[C@](C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(OC([H])(F)F)C(OC([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C2=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])SC(=C1[H])C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N1C(=NC(=C1C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
CC(C)N(CC1=CC=CC=C1)C(=O)CN1C2=C(C=CC=C2)N2C(=NN=C2C2=CC=CC=C2)C(C2=NNC3=C2C=CC=C3)C1=O
[H]N(C(=O)C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1CO[C@H]1O[C@H](COS(N)(=O)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C(=NN([H])C2=N1)N([H])C(=O)C1([H])C([H])([H])C1([H])[H]
[H]N1N=C(C2=C(C3=C([H])C(OC([H])([H])[H])=C([H])C(=C3N=C12)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])C2=NN=C(\C([H])=C(/[H])C3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])N2C([H])([H])C([H])([H])C1([H])[H]
CC(=O)NCC(=O)N1CCC2(CC1)CCN(CC1=CC=C(C)C=C1)C1=C(O2)C=CC=C1
OC1=CC=C(C=C1)[C]1234[B]567[B]89%10[B]%11%12%13[B]585[B]%118%11[B]%12%12%14[B]9%139[B]16%10[B]2%129[C]38%14[B]475%11
CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\C2=CC(O)=CC=C2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(\C#N)=C(/[H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C(Cl)S2)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C1=O)C1=C2C([H])=C(C([H])=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C2N=C(N=C(O[H])C2=C1[H])N([H])[H])C([H])([H])C([H])([H])[H])C(=O)O[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C2=C([H])OC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(Br)C([H])=C1OC([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C3=NC(=NS3)C(F)(F)F)C([H])=C2C([H])([H])C1([H])[H]
CC1=CC=C(C=C1)S(=O)(=O)N[C@H]1CNC[C@H](C1)C(=O)NCC(C1=CC=CC=C1)C1=CC=CC=C1
[H]N(C(=O)C1(N([H])C(=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C1=NN=C(O1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C(=O)C2=C(O[H])[C@]3([H])OC4=C(O[H])C([H])=C([H])C5=C4[C@@]33C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])[C@]([H])(C5([H])[H])[C@]3(O[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H]
[H]N([H])C1=NC([H])=C(N=C1[H])C1=C([H])N=C2N=C(SC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)C(F)(F)F)N1C([H])([H])C([H])([H])C2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=NC(=C([H])C([H])=C1[H])C1=C(C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C(=C([H])C([H])=C2C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(N=C1[H])C1=NC(=C([H])C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C(=O)C1=C([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C12
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(SC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1C#N)C1=NN=C(O1)C([H])([H])[H]
[H]N(C(=O)C(C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
CCCCCN1C=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C2=CC(=CC=C12)C1=CC=CC=C1
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])N=C1[H]
[H]N([H])[C@]([H])(C([H])([H])N1C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C#N
[H]N(C1=NC2=C(N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])(F)F)C(OC([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=[N+]([O-])C([H])=C1C(=O)C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]C1=NC2=C(C([H])=C1[H])N(C(=N2)C([H])([H])N1C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C([H])C(Cl)=C3[H])[C@@]2([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N([H])C([H])([H])[H])C(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]1([H])N([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@@]2([H])C3=C(C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O
[H]OC(=O)C([H])([H])S(=O)(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1=[N+]([O-])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(SC([H])=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=NC([H])=N1
[H]ON1C([H])=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])[C@]1([H])N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C(N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1F)C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])S1)C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=NN=C(N2C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
OC12CC3CC(C1)CC(C3)(C2)C(=O)N1CCC2=C1C=CC=C2
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1OC([H])([H])C([H])([H])O2)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C([H])=C([H])C(Cl)=C3[H])C2=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=NC(=N1)N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C(=NN2C3=C([H])C(F)=C([H])C([H])=C3OC([H])([H])[C@@]12[H])C(=O)C([H])([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=NN(C(=O)C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C(=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]N1N=C(C2=C(C3=C([H])C(Br)=C([H])C(OC(F)(F)F)=C3N=C12)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3C([H])([H])[C@]2([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C2=NN=C(N2C([H])([H])[H])C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C(OC(F)(F)F)=C1[H]
[H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]1([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(C1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(N1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H]
[H]N1C([H])=NC(=C1C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=NC([H])=C2C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1(SC(=NC1=O)N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(Br)=C1[H])C([H])([H])N1N=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
C[N]1=CC2=C(C=C1)C1=CC=CC=C1N2CCCCCN1C2=CC=CC=C2C2=C1C=[N](C)C=C2
[H]N(C(=O)C#CC([H])([H])[H])C1=C([H])N=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]SC1=NC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C3=NC([H])=NC4=C3N=C([H])N4[C@]3([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]3([H])O[H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C1=NN([H])C(=N1)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])[C@@]2([H])N(C3=C(C(Cl)=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N1C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)F
[H]N([H])C(=O)C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C2=NN(C3=C2N=C(C([H])=C3N(C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)N([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
CC1=CC=C(SC2=NC=C(S2)C(O)(C(F)(F)F)C(F)(F)F)C=C1
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1=C([H])C([H])=C([H])C([H])=C1Cl)C(=O)N([H])[H]
[H]OC(=O)[C@@]([H])(\N=C1/C(O[H])=C(O[H])\C/1=N/C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(Cl)S2)C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2(SC([H])([H])C([H])([H])S2)C1([H])[H]
[H]OC1=C(N([H])C2=NS(=O)(=O)N=C2N([H])[C@@]([H])(C2=C([H])C([H])=C([H])O2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(C([H])=C(N2[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC(=S)SS1
[H]N([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2O[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]4(N([H])C(=O)C([H])([H])SSC([H])([H])C(=O)N([H])[C@@]56C([H])([H])C([H])([H])C(=O)[C@@]7(OC8=C(O[H])C([H])=C([H])C9=C8[C@]57C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]6([H])C9([H])[H])C([H])([H])[H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(Cl)C(=C1[H])C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=O)N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1F
[H]OC(=O)C([H])([H])[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
NS(=O)(=O)C1=CC2=C3N(C(=NC3=C1)C1=CC=CC=C1O)C1=CC=CC=C1O2
[H]C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1=NN(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
CC(C)NC1=NC=C(S1)C1=CC(=NC(N)=N1)C1=C(Cl)C=CC=C1
[H]N(C(=O)C(\[H])=C(/[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H]
[H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C(=O)C([H])([H])OC(=O)C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])S(=O)(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C(=O)N(C(=O)N1C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(N(C1=S)C([H])([H])[H])C1=C([H])C2=C(S1)N(N=C2C(F)(F)F)C([H])([H])[H]
[H]N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3[C@@]1([H])C([H])([H])[C@@]([H])(C([H])([H])N3C(=O)N([H])C(=O)C3([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H]
[H]OC(=O)[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(O[H])=C2C(=O)C(OC(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])=C(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C(N=C(OC([H])([H])C3=C(ON=C3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C3([H])C([H])([H])C3([H])[H])C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C3=C([H])N=C(Cl)C([H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
CN1C(COC2=CC=CC(Cl)=C2)=NC2=C1C(=O)N(C)C(=O)N2C
[H]C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=N1)N(C(=N2)C([H])([H])N1C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]2([H])C1([H])[H])C([H])([H])[H]
COC1=CC(F)=CC(=C1)C1=CC2=C(OC(C)(C)CC22N=C(N)N(C)C2=O)C=C1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2OC(=O)C([H])=C([H])C2=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
NCCCN1C2=C(C(=O)C3=C2C=CC=C3)C2=CC=C(NCC(O)=O)C=C2C1=O
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C([H])C([H])=C1[H])N1N=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=NN=C(N1[H])C([H])([H])[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C1=NC(Cl)=NC2=C1N=C([H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)OC2(C([H])([H])C2([H])[H])[C@]2([H])N([C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C(=O)N([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])N1N=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C(=O)N(C2=C(OC1([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC(=C1[H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])C2=C(C(N([H])[H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1C([H])([H])[H]
[H]C1=C([H])C(OS(=O)(=O)C(F)(F)F)=C(C(OS(=O)(=O)C(F)(F)F)=C1[H])C1=C2C3=C4C(=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]4([H])C([H])([H])C2=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]\C(=C1/C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C2=NN([H])C([H])=C2[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N([H])N([H])C(=O)C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])=C([H])C([H])=C([H])N21
[H]N1C([H])=C2C(=C1\C([H])=C1/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C13)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC2=O
[H]N1N=NC(=N1)C1=C([H])C2=C(OC3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=NC([H])=C2S1
[H]OC([H])([H])[C@]1(OC(=O)\C(=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])N([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H]
[H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])\N=C(\S[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H]
[H]OC(=O)C(\[H])=N\O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])ON=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1Cl)C1=C([H])N=C2C([H])=C([H])C(=NN12)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3(C(=C([H])C([H])([H])[C@]4([H])[C@@]5(C([H])([H])[H])[C@@]([H])(O[C@]6([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]6([H])O[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@](C([H])([H])[H])(C([H])([H])OC(=O)C([H])([H])[H])[C@]5([H])C([H])([H])C([H])([H])[C@@]34C([H])([H])[H])[C@@]2([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(F)(=O)=O)C([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(F)(=O)=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C(=NC2=C1N([H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C#CC([H])([H])N([H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N=C(N([H])C([H])([H])C([H])([H])[H])C1=C([H])N=C(N2C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])[H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(C([H])=C2[H])N2C([H])=C([H])N=C2C2=C(C([H])=C(O2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C(OC([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2[H])C(=C([H])C(O3)(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C2=NC([H])=C([H])C([H])=C2C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3C([H])=C([H])C(=O)N(C3=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N1C(=O)C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C4=C5C(O[H])=NC(=NC5=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])C([H])=C2C1([H])[H])C(=O)O[H]
CC(C)NC(=O)C1=CC(NC(P(O)(O)=O)P(O)(O)=O)=NC=C1
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])([H])C([H])([H])C2=C3C([H])=C([H])C(N([H])C(=O)C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N1N=NC([H])=C1C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C(O[H])C([H])=C3O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O2
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C3=C(N=C(N=C3N=C2C([H])([H])[H])N([H])[H])N([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N(\C([H])=C(/[H])C(=O)C1=C([H])C([H])=C([H])S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N1OC(=O)C2=C1N(C1=C([H])C(Cl)=C(F)C([H])=C1C2=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(C#N)=C([H])N=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=C(C([H])=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]C1=C([H])N2C(=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N2[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H]
[H]C1=C2C3=C(N=C(C([H])=C3N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C1=C(OC([H])([H])[H])N=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(SC(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])\C(\[H])=C(/[H])C(=O)OC([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]1([H])O[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])\C(\[H])=C(/[H])C(=O)OC([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H]
[H]N(\C([H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(I)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(N2C([H])([H])[H])[C@]23C([H])([H])C([H])([H])[C@](C4=NOC(=N4)C4=C([H])C([H])=C(F)C([H])=C4[H])(C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C1=C([H])N(C2=C([H])C(SC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C2=C(N=N1)C1=C(C([H])=C([H])C([H])=C1[H])C2=O
[H]O[C@]([H])(C1=C([H])N=C([H])C([H])=C1N([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C1(C2=C([H])C(=C([H])C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(F)=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C(F)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C#N)C([H])=NN3C(=N2)N([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1
[H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])N=C([H])O3)C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])SC([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H]
[H]N1C(=NC2=C3C([H])=C([H])C(Br)=C([H])C3=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=C12)C1=C(F)C([H])=C([H])C([H])=C1Cl
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=C2SC(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C1([H])[H]
[H]N(C(=O)C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)C(F)(F)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(SC([H])=C2[H])C(=N1)N1C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC([H])([H])[C@@]([H])(C(=O)O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])=N[H])[C@]([H])(C1([H])[H])[C@@]1([H])O[C@@]21[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1OC([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(N=NN2C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C(=N1)C1=C([H])C([H])=C([H])O1
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C(C([H])=C([H])C(F)=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C([H])=C2N(C(=O)C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C2C(=C(O[H])C3=C1C(=O)C1=C(C3=O)C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@@]([H])(O[C@]1([H])O[C@@]([H])(C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(N([H])[H])C1([H])[H])C([H])([H])[C@](O[H])(C(=O)C([H])([H])[H])C2([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)C(F)(F)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(O[H])O[H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H]
[H]N(C1=C([H])C2=C(OC3=C2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])N([H])C2([H])[H])C1([H])[H])C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(SC2=C(N([H])[H])C([H])=C(F)C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)O[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=C([H])C2=C([H])C(F)=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C#C[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C([H])([H])[C@@]1(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1(Cl)Cl
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O\C(=C(\SC([H])([H])[H])/C(/[H])=C(/[H])C(=O)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C(C(C#N)=C1[H])C(F)(F)F)N1C(=O)[C@@]2([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])[C@@]2([H])C1=O
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C3=C2[C@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]([H])(N2C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C2([H])[H])C3=O)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C2([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(OC([H])(F)F)C([H])=C2[H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C3(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(OC([H])([H])[H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC(=O)NCC1=CC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)=C1
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=N1
[H]N(C(=O)C([H])([H])SC1=C([H])C([H])=C([H])C([H])=N1)[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C(Cl)C2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])S[C@@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])F
[H]C1=C(C([H])=C(SC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C(=O)N(C3=C2[H])C([H])([H])[H])S1)[C@]1(OC(OC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
Cc1cnc(NCC2CCOCC2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]N([H])C1=N[C@]2([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])C(=N1)N([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C(SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C3=NC([H])=C([H])N3C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1\C(=N\C(=O)C2=C([H])C([H])=C(S2)C2=C([H])N([H])N=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1N=C(N(C1=S)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C(=NC2=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(F)C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C2=C([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3O2)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C2=C(C([H])=C3C(N([H])C(C([H])=C3C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C2=C1C(F)=C([H])C(F)=C2[H]
[H]N(C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Br)C([H])=N1
[H]C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C3N1C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C2[H]
[H]N=C(N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=NN(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=NC2=C([H])C([H])=C(Cl)C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
COC1=CC=C(SC2=CC=C3CN(C(=O)C3=N2)C2=CC=C(OCCN3CCCC3)C(OC)=C2)C=C1
[H]OC(=O)C([H])([H])N1C(=S)S\C(=C(/[H])C2=C([H])N(N=C2C2=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]2([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C([H])=NC2=C(C([H])=NN12)C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC(=N1)C([H])([H])[H]
[H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(C2=C([H])SC([H])=C2[H])C2=C1C1=C([H])C(=C([H])C([H])=C1C2([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]O[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])N([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])[C@]([H])(O1)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)NC1=CC=C(C=C1)N1CCCCC1
[H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])OS(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=NC2=C(S1)C([H])=C([H])C(N([H])C(=O)C1=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=N4)C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C1=C([H])C2=C(N=C(O2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])N=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C3N(C(=O)SC3=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=NN=C(N2N(C1=O)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C(=O)N([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(O[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
C[C@@H]1CN(CCN1C1=NC=C(OCC2=C(C=NC=C2)C#N)C=N1)C1=NOC(=N1)C(F)F
OC(C1=CC=NC=C1)C1=CC2=C3N(CCC3=C1)C(=O)CC2
[H]C1=C(C#N)N(C(=C1[H])C1=C([H])C(F)=C2N(C(=O)C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O\N=C1\C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])O[H]
[H]OC(=O)C([H])([H])[C@@]1(O[H])C2=C(O[C@@]([H])(C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(F)=C2[H]
[H]N([H])C1=C([H])C(=NC(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1C#N)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@@]([H])(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(N([H])C(=O)C(F)(F)F)=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=O
[H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1([H])C([H])([H])C1([H])[H])C(=O)N([H])[H]
[H]ON([H])C(=O)C1=C([H])C(Br)=C([H])C(=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])SC([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])C1=C(Br)C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1C(=O)N(C2=C1N=C(N=C2N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C#N)C2=C(C(SC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=N1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(SC1=C(Cl)C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C2=C([H])C(=C(Cl)C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])[C@]2([H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C(=O)C([H])([H])N(C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(N(C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])C([H])=C3[H])C1([H])[H])C1=C2C([H])([H])N([H])C1=O
[H]N(C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(C#N)C#N)C([H])([H])[H]
[H]C1=C(N=C2C(=C1[H])N(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C1=NN(N=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C(F)(F)F
[H]N(C1=NC(=O)\C(N1[H])=C1\C2=C(N([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F
CC(C)(C)C[C@@H]1N[C@H]([C@H](C2=C(F)C(Cl)=CC=C2)[C@]11C(=O)NC2=C1C=CC(Cl)=C2)C(=O)NCCN1CCOCC1
[H]N([H])S(=O)(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OS(=O)(=O)N([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@@](N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NOC(=C1[H])C([H])([H])[H])(C(=O)OC([H])([H])C([H])([H])[H])C(F)(F)F
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])\N=C(\S[H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C2N([H])C([H])=NC2=NC(=N1)C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C(\N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(\[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]([H])(O[C@@]1([H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H]
[H]N(C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(N=C1C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=N1)C([H])=C(Br)C([H])=N2
[H]OC(=O)[C@@]1([H])N([H])C(=O)C2=C([H])C([H])=C([H])C(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C3=C([H])C([H])=C(O[H])C([H])=C3[H])C([H])([H])SSC1([H])[H])=C2[H]
[H]C1=C(Cl)SC(=C1[H])C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=O)N(C3=C2N=C([H])C([H])=C3[H])C([H])([H])C(F)(F)F)C1([H])[H]
[H]N(C1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)[C@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(C([H])=C2Cl)C(=C([H])C(=O)O3)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H]
C1CCC(CC1)N1CCCC2=CN=C3NC=CC3=C12
[H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])=C([H])C([H])([H])N2N1C(=O)N(C2=O)[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])SC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]1(C([H])([H])[H])C([H])([H])C2=C(N([H])C3=NC([H])=C(O3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C(SC2=N1)C([H])([H])C([H])([H])[H]
[H]N(C1=NN=C(C2=C1C([H])=C1C([H])=C([H])C([H])=C([H])N21)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])N2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=O)N(C2=NC(=NC(=C12)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1
OC1=CC=C2OS(=O)(=O)C=CC2=C1
[H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)N2[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C([H])C(F)=C([H])C(F)=C3C([H])([H])[H])N(C3=C([H])C([H])=NC([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C([H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])N(C(=O)C3=C(N=C([H])N=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1(O[H])C2=C(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])=C(F)C(F)=C2[H]
[H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CCCCCCNC1=C2C3=CC=C(OC4=CC=C(C=C4)C(C)C)C4=CC=CC(C2=NC1=O)=C34
[H]OC(=O)[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C(F)=C3[H])N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NN1C(=O)C1=C(C([H])=C([H])S1)C([H])([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]C1=NC2=C(C(=NO2)C([H])([H])[H])C(SC2=C([H])C([H])=C([H])C([H])=C2Cl)=N1
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N1C(=NN=C1C([H])([H])[H])C1=C([H])C2=C(OC([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C([H])=C1[H]
[H]N(C1=NOC([H])=C1[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H]
[H]N(C(=O)C([H])([H])SC1=NC2=C(S1)C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C2C([H])=NN(C2=NC([H])=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N2C3=C(OC([H])([H])[C@]2([H])C([H])([H])C([H])([H])[H])C(F)=C(F)C([H])=C3C1=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C1=C([H])C(=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=C2[H]
CC1=CN=C(C)C2=NC(=NN12)C1=CC2=NC(=CN2C=C1)C1=CC=CC=C1
[H]N(C(=O)OC([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])C([H])([H])N([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
Cc1ccc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)NCc2cccc(c2)C(F)(F)F)cc1C
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1=NC([H])=C([H])N1[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]C1=C([H])C([H])=C(S1)C1=NOC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])C2=C([H])N=C([H])S2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=NN(C2=N1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Br)=C1[H]
[H]O[C@@]1([H])C([H])=C([H])[C@@]23C4=C(O[C@@]2([H])C1([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C4C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C3([H])[H]
[H]\C(=C1\SC2=NC([H])=NN2C1=O)C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]OC1=C2C(SC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=NC(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=N1
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Br)C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C(=C(S2)C(F)(F)F)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
CC1=C(C)C(NC(=O)N2CCN(CC2)C2=NC(=CS2)C2=CC=CC(F)=C2)=NO1
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OP(=O)(O[H])OC([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@]([H])(C(=O)[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])OC(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=NC(Cl)=C4[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C(Cl)=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C1C([H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1Cl)[P@](=O)(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(N(C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1N=C(N([H])[H])C2=C([H])C(=NN=C12)C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C#CC([H])([H])[H])C(=O)N(C([H])=N3)C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])C([H])=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C1=O
[H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(O[H])=C1C1=C([H])C(N=C=S)=C([H])C([H])=C1[H]
[H]N1N=C([H])C(OC([H])([H])[H])=C(C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]C1=C([H])N(N=N1)C([H])([H])[C@]1([H])OC(=O)N(C2=C([H])C([H])=C(C(F)=C2[H])C2=C([H])N=C(C([H])=C2[H])C([H])([H])OC([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C2N=C(C(=C([H])C2=C1N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])(F)F
[H]N(C(=O)C([H])([H])C([H])([H])C1=C2C(N([H])C([H])=C2C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N([H])C1=NC([H])=C(C([H])=C1[H])C1=NN=C(N1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=N3)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C(=S)N([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(N([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])S[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1N([H])C1=C(Cl)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(S1)C1=C([H])N=C2C([H])=C(C([H])=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=NC3=C(N=C2[H])N=C(N(C3=O)C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])S(=O)(=O)N([H])[H]
[H]C1=C([H])C([H])=C2N(N=NC2=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=N[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C#N)C2=C1C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])S2
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])N(C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1N=C(C([H])=C1C1=C([H])C([H])=C2C([H])=C(OC(F)(F)F)C([H])=C([H])C2=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N([H])C(=O)N2C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C(N=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C(=C([H])C([H])=C2[H])C1=C([H])C(=C2N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C2=C1Cl)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(Cl)N=C([H])C([H])=C1[H])C1=C(N([H])C(=O)C2=C(Cl)N=C([H])C([H])=C2[H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H]
[H]N([H])C1=NC2=C([H])C(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3OC([H])([H])[H])=C(C([H])=C2C(=N1)N([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C1=C(SC2=NC(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[H])C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(F)C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C#N)=C([H])C(=C1[H])N1N=C([H])C(Cl)=C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=O
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N([H])C1=NON=C1C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=NOC3=C([H])C(F)=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C(O[H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C1=C2N=C([H])C([H])=C(C2=C(OC2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C(=C([H])O3)C([H])([H])[H])C(F)(F)C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)[C@@]1([H])C2=C(N(C(=O)C([H])=C2[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(I)=C2[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([C@]1([H])C(=O)N(C2=C([H])C3=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(Cl)=C([H])N([H])C2=C1[H]
CC1=CC(NC(=O)CC(O)=O)=C2CCCC2=C1OC1=CC(CCC2=CC=C(F)C=C2)=C(O)C=C1
[H]OS(=O)(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C([H])=C([H])C([H])=N4)C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])N(C3=C(O2)C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C(=O)C(F)(F)F)C([H])([H])[H]
[H]N1C(SC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C(N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(F)=C(C([H])=C1F)[C@]([H])(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C(C#N)C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=C(C([H])=C([H])S1)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2=C(N=C(N2C([H])([H])[H])C(F)(F)F)[C@@]1([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]ON(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])[C@](O[H])(C2=C([H])C([H])=C([H])C(Cl)=C2C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])[H])C([H])([H])[C@@]1([H])N([H])[H]
N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1CC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@@H]1C(N)=O
[H]N(C(=O)OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(C#N)=C(C([H])=C1OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C2=C1C([H])=NC(=N2)C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1(F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])N(C(=O)C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])([H])[C@]2([H])C1([H])[H]
CC1=NC2=C(C=CC(=C2)C(O)=O)N1C1=CC2=C(C=C1C)C(C)(C)CCC2(C)C
[H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])[C@](C1=C([H])C([H])=C(Cl)C([H])=N1)(C1=C([H])C(F)=C([H])C(OC(F)(F)C([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C(F)(F)C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C([H])S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]12C([H])([H])C3=C(N=C([H])C(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C5([H])[H]
[H]N([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C3=C(N=C([H])N=C3C([H])=C2OC([H])([H])[H])N([H])C2=C(F)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])\N=C(/[H])C1=C([H])C(OC2([H])C([H])([H])SC2([H])[H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])N1C([H])([H])C([H])([H])C2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C(C([H])=C2N=C1[H])C1=C(C(=O)N(N1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])[H]
[H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([O-])=O
[H]N(C(=S)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H][C@@]12CC3CC(C3(C)C)[C@]1(C)OB(O2)[C@H](CCCN=C(N)N)NC(=O)C1=CC(=CC=C1)C1=CC(NS(C)(=O)=O)=CC=C1
CC(C)C1=C(CC2=CC=C(CCCC(N)=O)C=C2)C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN1
[H]N([H])N([H])C([H])([H])C(=C([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)[C@]1([H])C(C#N)=C2SC([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N2C(=O)C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1N=C(C#N)C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]OC(=O)C1=C(N([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(\C([H])=C(/[H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C2N=C1[H]
[H]OC1=NC2=C(C([H])=C3C(N([H])[C@]([H])(C([H])([H])[H])C3(C([H])([H])[H])C([H])([H])[H])=C2[H])C(=C1[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=NC([H])=C([H])N1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O
[H]N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])O[H]
[H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]