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[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N(C(=C(C1=O)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])N([H])N=C1C1=C([H])C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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CCCN(CCC)C(=O)C1=CC(=CC(=C1)N(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](O)CNCCC1CCN(CC2=CC=CC=C2)CC1
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC2=C([H])C(O[H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])C(=C([H])C(C#N)=C1[H])[N+]([O-])=O
[H]C1=C(N=C(S1)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C(=O)C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]ON(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
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[H]N1C([H])([H])C(C(=O)N(C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC2=C(F)C([H])=C([H])C(F)=C2Cl)C(F)(F)C1([H])[H]
[H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(C(=O)C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C2=C(N(C(=O)C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(OC(=O)C([H])=C2C2([H])C([H])([H])C2([H])[H])N=C1C([H])(F)F
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C3=C(N=C([H])C([H])=C3N2C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C2=C(C(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C(N=C2C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(F)(F)F
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=N/N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H])C1=C2C([H])=C(I)C([H])=C([H])N2N=C1[H]
[H]C1=C(SC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C(=O)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C#N)C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])O[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@@](O[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C2\C3=NC4=C([H])C(Cl)=C([H])C([H])=C4C(=O)N3C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C2N([H])C2=C3C3=C(C(=O)N([H])C3=O)C3=C2C([H])=C([H])C2=C3N(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=NC([H])=C(N1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]C([H])=C([H])C([H])([H])N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(=C(F)C([H])=C3Cl)S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])N(C([H])=N2)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C(=O)O[C@@](C([H])([H])C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])C(C#N)(C([H])([H])[H])C([H])([H])[H])(C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])[C@@]3([H])N(C(=O)O[C@]([H])(C([H])([H])[H])C(F)(F)F)C([H])([H])[C@]2([H])C3([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C3=C(C([H])=C(S3)C(=O)N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])([H])C([H])([H])OC2=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]C#CC([H])([H])N([H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2SC([H])=C(C2=C1[H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NC2=C(C([H])=C1[H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H]
[H]C1=C([H])C([H])=C2C(=O)N(C(=O)C2=C1[H])[C@]([H])(C1=NN2C(S1)=NN=C2C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C2=C(N=C1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]\C(\C(\[H])=C(/[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])=C(\[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]C1=C2C([H])([H])C([H])([H])[C@@]3([H])C(=C([H])C([H])([H])[C@@]4(C(=O)C([H])([H])C([H])([H])[C@@]34[H])C([H])([H])[H])[C@@]2(C([H])([H])C([H])([H])SC([H])(F)F)C([H])([H])C([H])([H])C1=O
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[H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]N(C(=O)C1=C(Cl)C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C1=C([H])N=C([H])S1
[H]N1C(=O)C(N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=NC([H])=C2[H])N1C1=NC([H])=C([H])C(=N1)N(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C([H])=C([H])C1=C([H])C([H])=C2C(N([H])C(=O)\C2=C2/N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2=O)=C1[H]
[H]N(C(=O)C([H])([H])S(=O)(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C2=C(SC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C1=N[C@@]([H])(C([H])([H])[H])C([H])([H])O1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C(O1)C(=O)[C@@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C2C([H])=C([H])C([H])=C([H])C2=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC([H])([H])C1=NN(C(=C1C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(Cl)C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C([H])([H])C1=C(N=C(N=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1=O
[H]OC1=NC2=C([H])C([H])=C(C([H])=C2N1C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])F
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[H]\C(=C1/C2=C([H])C([H])=C([H])C([H])=C2SC2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]OC([H])([H])C1=NC([H])=C([H])N1C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=NN2C2=C([H])C([H])=C3ON=C(N([H])[H])C3=C2[H])C(F)(F)F)C(F)=C1[H]
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[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NOC(=N1)C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]C([H])=C([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])S1)C1([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])[C@](OC([H])(C([H])([H])[H])C([H])([H])[H])(OC1=O)C([H])([H])[H]
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[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
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NS(=O)(=O)NC1CCC2=C(C1)C=CC=C2
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[H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C(SC4=C2C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H]
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[H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])N2N=C(OC3=C([H])C(N([H])C(=O)C4=C([H])C(=NN4C([H])([H])[H])C([H])([H])[H])=C(C([H])=C3[H])C([H])([H])[H])C([H])=C([H])C2=N1
[H]OC(=O)C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(=O)C(O[H])=C2OC2=C1C([H])=C([H])C(O[H])=C2O[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=N2)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C(=C(Cl)C([H])=C2N2C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]2([H])C1=O)C(F)(F)F
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[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C([H])([H])N1C(=S)S\C(C1=O)=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)O[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(SC([H])=C2[H])C([H])([H])N([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C#N)C(=N\C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])\N1C([H])([H])C([H])([H])C(=C2C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(F)(F)C(F)(F)F
[H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[C@@]([H])(\N=C(/N([H])C#N)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]N([H])C1(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])[C@@](N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])(C(=O)OC([H])([H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S(F)(=O)=O
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])N=C2N=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])N=C(S1)N1C([H])([H])C([H])([H])C([H])(SC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
[H][C@]1(CS[Se]C[C@H](N)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)NCC(N)=O
[H]C1=NN(C(=N1)C(C([H])([H])[H])(C([H])([H])[H])[C@]1([H])C2=C([H])C(=C(Cl)C([H])=C2[C@@]2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)[C@]1([H])C([H])([H])N(C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(N([H])C2=NC3=C(C([H])=N2)C([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])N=C32)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]C1=NC(N2C([H])([H])C([H])([H])N(C3=NC([H])=C(C#N)C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C([H])([H])N1N=C([H])C(OC2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C23)=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]C1=NN2C(=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C(O[H])=C1[H])C(=O)C1=C(O2)C2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]N([H])[C@@]([H])(C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C([H])C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])C([H])=C12
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1(C#CC2=NC(N([H])[H])=C3N=C(N(C3=N2)C([H])([H])[H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])SC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])S1
[H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(S1)S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H]
CCN(CC)C1=CC=C(CN(CC2=CC=CC=C2)S(=O)(=O)C2=CC3=CC=CC=C3C=C2)C=C1
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]N1C2=NC([H])=C([H])C(=N2)C2=C([H])C(=C([H])O2)C([H])([H])OC([H])([H])\C([H])=C([H])\C([H])([H])OC([H])([H])C2=C([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=N\OC([H])([H])[H])\C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2SC3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]N([H])C1=N[C@]([H])(N(C(=N1)N([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C(OC([H])([H])[H])=NN2N=C1[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])N=C12)C1=C([H])C([H])=C2N=C([H])C3=C(N(C(=O)C([H])=C3[H])C3=C([H])C(=C(F)C([H])=C3[H])C([H])([H])[H])C2=C1[H]
[H]N([H])C([H])([H])C1=C2N(C([H])=NC2=C([H])C([H])=C1C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)C1(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C(=O)C1=NN(C(C2=C([H])C([H])=C(S2)C#CC([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
Cl.C=CCCN1CCC2(CCCC3=CC=CC=C23)CC1
[H]\C(C1=C([H])C([H])=C([H])C([H])=C1OC([H])(F)F)=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N(C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N(C1=NC(=C([H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(\C(=N/C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C2OC([H])([H])OC2=C([H])C(OC2=C([H])C3=C(N=C(N(C3=O)C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N2)=C1[H]
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[H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=[N+]2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C2(C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])SC2([H])[H])=C1[H]
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[H]N(C(=S)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=NN1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C(=O)[C@]2(C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]3([H])OC([H])([H])[H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)C1(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C(=NC(OC([H])([H])[H])=N2)N([H])C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])[S@](=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(N([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(N=C1[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1C(=O)N1C([H])([H])[C@]([H])(OC2=NC([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
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[H]OC1=C2O[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]4(N([H])C(=O)C([H])([H])C([H])([H])C5=C([H])C([H])=C(C([H])=C5[H])[N+]([O-])=O)[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H]
[H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])[H])C2([H])[H]
[H]N([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C2C(=C1[H])N(C([H])=C2C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C(F)C([H])=C(I)C([H])=C2[H])N(C2=C1C([H])([H])C([H])([H])C([H])([H])C2=O)C([H])([H])[H]
[H]N(C(=O)O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC([H])=NC([H])=C1[H]
[H]OC([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NC(C(=O)N([H])[H])=C(N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])N2N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C([H])C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])F)=C(OC([H])([H])[H])C(=C1[H])C(=N\OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[H]
[H]N([H])C1=NOC2=C([H])C([H])=C(C([H])=C12)N1N=C(C([H])=C1C(=O)N1C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])N(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)(C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(C#CC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC([H])([H])[C@]1(OC(=O)\C(=C(\[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]OC([H])([H])C([H])([H])C([H])([H])N(C1=NC(=C2C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])=C([H])C2=N1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]C([H])=C([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]2([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(F)=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)OC(C2=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C(=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])OC1=C(N=C(C([H])=C1[H])C([H])([H])[H])[N+]([O-])=O
[H]N([H])C1=C(N2C([H])=C(C([H])=C([H])C2=N1)C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])N=C(S1)N(C([H])([H])C1=C([H])C([H])=C2N=C(N=C(O[H])C2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O[H]
CC1=CC(N[C@H](CCCCNCC2=CC=CC(F)=C2)C(=O)NO)=CC(C)=C1F
[H]N([H])C(=NC(=O)C1=C(N([H])[H])C([H])=C(O1)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])N([H])[H]
ON(=O)C1=CN=C2NC=C(\C=C3/N=C(NCC4=CC=CC=C4)NC3=O)C2=C1
[H]N(C(=O)OC1=C([H])C2=C(N([H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]23C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
CN1C(N)=NC2(CC(C)(C)OC3=C2C=C(C=C3)C2=CC=CN=C2)C1=O
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[H]N(C(=O)N([H])[C@](C1=C([H])C([H])=C(Cl)C([H])=N1)(C1=C([H])C(F)=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])[C@@]([H])(C([H])([H])F)C2([H])[H]
[H]N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C([H])=C(OC3=C([H])C4=C(C([H])=C3[H])N(C(=O)N([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])O4)C2=C1[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)OC3=C2C([H])=C(Cl)C([H])=C3[H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
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[H]N(C(=O)[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C(N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2S1
[H]C#CC([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NN=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
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[H]OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C(O[H])=C([H])C([H])=C1C2=O
[H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C2C([H])=C(F)C([H])=C3[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=NC2=C1C([H])=C(N2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])=NC2=C1C([H])=NC([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C([H])=N1)C1=C([H])N([H])C2=C([H])C([H])=C([H])C(Br)=C12
[H]C1=C([H])C2=C(C([H])=C1[H])C1=NC(=NN1C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C(=O)N([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2C(=O)OC([H])([H])C2=C(C(OC([H])([H])[H])=C1C([H])([H])C(\[H])=C(\C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])O[P@](=O)(O[H])C([H])([H])[P@@](=O)(O[H])OC([H])([H])[C@]1([H])O[C@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])[H]
CC(OC1=CC=CC=C1)C(=O)NC1=CC=C2N=C(NC2=C1)C1=CC=NC=C1
[H]S\C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C1/C([H])=C([H])C(=O)C(OC([H])([H])[H])=C1[H]
[H]N(C1=C(N=C2C([H])=NC([H])=C([H])N12)C1=C([H])C([H])=C2N([H])N=C([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1(N([H])C(=O)C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(SC(=C2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N([H])C(=O)C1=C([H])C2=C(S1)C([H])=NC([H])=C2SC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(\C([H])=C(\[H])C([H])([H])[H])C([H])=C1[H])C2([H])[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2\C(=O)C3=C(O[H])C([H])=C(O[H])C([H])=C3OC2([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
Cc1cccc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)N[C@H](CO)c2cccc(Cl)c2)n1
[H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])O[C@@]1([H])[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C#N)(C2=C(C#N)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C#N)=C(Cl)N=N1
[H]O\N=C1/C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(SC3=NN4C([H])=C([H])C([H])=C4C(=N3)N([H])C3=NN([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C(Br)=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(N=C1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N([H])C1(C2=NC3=C(S2)C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C(OC([H])([H])[H])C(=NC2=C(Br)C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C(N([H])C(=O)OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C(=O)C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]C([H])=C([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)C([H])([H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])[H])C([H])([H])[H]
COC1=CC=C(C=C1)C(CCCN)(C1=CC=CC=C1)C1=CC=CC=C1
[H]N(C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C(OC([H])([H])C([H])([H])[H])C([H])=C(C(OC([H])([H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]C1=C(C([H])=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])([H])C2=C1C(OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NC([H])=C2[H]
[H]N([H])C1=NC(=NC(=N1)C([H])([H])Cl)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C2=NC([H])=NC(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])SC([H])([H])C([H])=C([H])[H]
[H]N([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(=NN2C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C(N1N2C([H])([H])C([H])([H])C1=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=NC(=C([H])C([H])=N2)C2=C([H])N=C(N2C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2N([H])C1=O)C([H])([H])[C@]([H])(F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1[C@@]2([H])C(=C([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])N=C(Cl)C([H])=C1[H]
[H]N(C(=O)C(C([H])([H])[H])(C(F)(F)F)C(F)(F)F)C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N2C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@]4(S[C@@]3([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H]
[H]C1=C([H])N(C([H])=N1)C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=N1)C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(SC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C(Br)C(=N1)C1=C([H])N([H])N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)C(=N/OC([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C([N+]([O-])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C2N(C(=O)C(=O)C2=C([H])C(OC(F)(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(C1=NN=C2N1C([H])=C(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C2\SC(=O)N([H])C2=O)C([H])=C1Br
[H]OC(=O)C(\[H])=C(/[H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N([C@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]OC1=NC2=C(C([H])=C(C([H])=C2[H])[C@@]([H])(N2C([H])=NC([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])[N+]3(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C1C2=O
COC1=CC=CC(=C1)C1=CC=C2CN(C(=O)C2=N1)C1=CC=C(OCCN2CCCC2)C(OC)=C1
CC(C)C[C@H](CO)NC1=NC(SCC2=CC(=CC=C2)C#N)=NC2=C1SC(N)=N2
[H]OC1=C([H])C([H])=C(Cl)C2=C1C1=C3C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C2([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC4=C([H])C5=C(C([H])=C4[H])C(=O)N([H])C5([H])[H])C(Cl)=C3[H])=C12
[H]OC1=C([H])C(O[H])=C(O[H])C([H])=C1C([H])([H])C([H])([H])N([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C(N=C(S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N=N2)C2=NC([H])=C(O2)C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(F)(F)F)C1(C2=NN=C3N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])N(N=C4[H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C([H])(N1C(=O)N(N=C(C#N)C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC(=O)C3=C([H])C([H])=NC([H])=C23)C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#CC([H])([H])C([H])([H])C([H])([H])C#C[H]
CO[C@H](C[C@H](CCN1CCCC1)C(=O)NO)C1=CC=C(F)C=C1
[H]N([H])C(=NOC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(OS(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H]
CC1(C)CC(=O)C2=C(C1)NC(=CC2C1=CC=C(C=C1)N(O)=O)C1=CC=CC=C1
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])N=C([H])C([H])=C3[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H]
[H]N([H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2OC(F)(F)C(F)(F)OC2=C1[H]
[H]N([H])C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])=C1C(=O)OC([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2C([H])([H])[H])N1C([H])([H])C([H])([H])C2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
CN1C=C(C2=NC3=C(O2)C=C(CC(=O)N2C[C@@H](F)C[C@H]2CO[C@H]2CC[C@@H](CC2)C(O)=O)C=C3)C2=C1C=CC(Cl)=C2
[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(SC(=C1[H])C(=O)C([H])([H])[H])N1C(=O)O[C@@]2(C1([H])[H])C([H])([H])[N@]1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C1=NC(=NO1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C(\[H])=C(/[H])C(N1N=NN=C1C([H])([H])[H])=C(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(=C([H])C(C([H])=C([H])[H])=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C([H])=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])N=C([H])C(=C1[H])C1=C([H])N=C2N([H])C([H])=C(C2=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=NC2=NC(SC([H])([H])C3=C(Cl)C([H])=C([H])C(Cl)=C3[H])=NN12)C([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C(=O)N([H])C4=C([H])N=C([H])C([H])=C4[H])[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=N2)C2=C1C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C2([H])[H]
[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])S1
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NN(C(=O)C2=C1C([H])=C([H])C(F)=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])N(C(=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])S1(=O)=O
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C2=C1N=C([H])N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C(=O)C([H])([H])[H])[C@]([H])(N(C1=O)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC([H])([H])[H])C1=C(C(=O)C([H])([H])[H])C(=O)N(C2=C1C([H])=C(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=N2)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]N(C1=NN([H])C2=C1C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(C([H])=C2C1=O)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]\C(=C(\N1C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C(=O)N([H])C1=NOC(=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C1=NN=C(S1)N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1N=C(C([H])=C1C1=NN=C2SC([H])([H])C(=NN12)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N=C(SC([H])([H])C2=NC3=C(Cl)C([H])=C([H])C([H])=C3C3=C([H])C(=NN23)C([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2N=C(C(=C2N=C([H])N1[H])[C@]1([H])N([H])[C@]([H])(C([H])([H])O[H])[C@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])[H]
[H]OC1=C2C([H])=C(SC2=NC(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N1N=C([H])C2=C1N=C(N1N=C(N=C21)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(Cl)S2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC(OC([H])([H])[H])=C3C(=N2)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]\C(=C1\SC2=NC([H])=NN2C1=O)C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C1=NC(=NO1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C1=NN=C([H])O1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C(F)=C2[H])=C([H])C(O[H])=C1[H]
[H]N1C(=O)N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C(C([H])=C23)C2=NN(C([H])=N2)C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C(=O)[C@]([H])(N([H])C(=O)C2=C([H])C3=C(SC(Cl)=C3[H])N2[H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)[N+]([O-])=O)C1=C([H])C([H])=C([H])C(Br)=C1[H]
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[H]OC1=C(O[H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C([H])C([H])=C3N1[H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(O[H])=C1[H]
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[H]OC1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
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[H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(C([H])=O)C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N2C3=C(C([H])=C([H])C([H])=C3C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C(=O)C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)[P@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C1=NN=NN1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC2=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H]
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[H]O[C@]([H])(C([H])([H])S[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])(F)F
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C(=O)C2=C(N(C3=C([H])C(Br)=C([H])C([H])=C23)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C1[H]
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[H]C1=C([H])N(C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1N([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=NN(C(=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C2=C1N=C(N2C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(F)F
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2C3=C([H])C([H])=C([H])C([H])=C3C(=O)C2=C1[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]N(C1=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]