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[H]C1=C([H])C([H])=C(C(=C1[H])C1=NOC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C(Br)C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12
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[H]N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=NN2C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2F)C(F)(F)F)C([H])=C1[H]
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[H]C1=NN(C([H])=C1[N+]([O-])=O)C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1(SC([H])([H])C([H])([H])S1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])S(=O)(=O)N([H])C1=NN=C(S1)C1=C([H])C([H])=C(Br)C([H])=C1[H]
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[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C([H])([H])OC(=O)C4=C([H])C([H])=C([H])C(F)=C4[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
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[H]O[C@@]1([H])[C@]([H])(O[C@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)\C2=C(\[H])C2=C([H])C([H])=C([H])N2[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN(C([H])=N1)P([O-])(=O)OP([O-])([O-])=O
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C1N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)O2)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C2\C(=O)C3=C([H])C([H])=C([H])C(N([H])[H])=C3C2=O)C([H])=C1Br
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2[C@@]([H])(N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C3([H])[H])C1([H])[H]
[H]N([H])C1=C2C(OC(=C2C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])=NC([H])=N1
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[H]OC([H])([H])C([H])([H])C([H])([H])N1C(=O)[C@]([H])(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
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[H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C([H])=C1[H]
[H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C(C#N)C#N)C1=C([H])C([H])=C([H])C2=C1N([H])C([H])=C2Cl
[H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])\C([H])=C([H])/C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H]
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[H]N([H])S(=O)(=O)C1=C([H])C(F)=C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]N([H])C1=NC(=NC2=C1C(=C(N2[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H]
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[H]N([H])C1=C2C(OC(=C2C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])C2=C([H])N=C([H])C([H])=C2[H])=NC([H])=N1
[H]N1C([H])=C(C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
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[H]OC1=NC2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3N([H])C2=N1
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[H]O[C@]1(C#CC2=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
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[H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
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[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])C([H])([H])N([H])C2=C([H])C([H])=NC([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])=C(C(=O)C2=C3N(C([H])=C2[H])[C@@]([H])(SC3([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([C@]([H])(C(=O)C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C(O[H])=C(C(=O)N([H])C4=C([H])C(=NO4)C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])N(N=C2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C1=C([H])N([H])C([H])=C(C(=O)OC([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N([H])C1=NC2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C(C2=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C#CC([H])([H])N(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3OC([H])([H])[H])C(=O)C(F)(F)F)C([H])([H])C2([H])[H])=C([H])C(F)=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC4=C([H])C([H])=C5C(=C4[H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C6=C(C([H])=C([H])C([H])=C6[H])[C@]54[H])=C([H])C([H])=C13)C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H]
[H]C1=C(C([H])=NO1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=NOC3=C([H])C4=C(C([H])=C23)C([H])([H])C(=O)N4C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)[C@@]1(N([H])C(=O)OC1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C([H])([H])SC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NOC2=C1C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C2N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(S1)C1(C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C(C([H])=C(S1)C(=O)C([H])([H])Cl)C(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=C([H])C(=NC(=N1)S(=O)(=O)C([H])([H])[H])C(F)(F)F
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
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[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(OC2=C([H])C(=NC([H])=C2[H])C(=O)N([H])C([H])([H])[H])=C1[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F
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[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]2(C1=O)[C@]([H])(C(=O)C1=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])[C@@]21C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(C1=C(C(=O)N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=NC4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C34)C(F)=C2[H])C(=O)N(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[S@](=O)C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@](C1=C([H])C2=C([H])C(C#N)=C(C([H])=C2N1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]([H])(C([H])([H])OC(=O)C([H])([H])[H])C1([H])[H]
[H]OC(=O)[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[C@@]2([H])O[C@@]([H])(C3=C([H])C(Cl)=C([H])C([H])=C3N3C([H])=C([H])C([H])=C23)C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])=C(C(=O)N=C1SC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Br)=C(OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H]
[H]N([H])C1=NC(\C([H])=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2\C([H])=N\N2C(=O)OC([H])([H])C2([H])[H])=C([H])C(=N1)C([H])([H])[H]
[H]N(C1=NC([H])=C(C(=O)N2C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=N1)C1=C(OC([H])([H])[H])N=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
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[H]OC([H])([H])C([H])([H])OC([H])([H])N1C([H])=NC2=C1C(=NC([H])=N2)N([H])[H]
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[H]OC1=C2O[C@]3([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]4([H])C([H])([H])C([H])([H])[C@]5(O[H])[C@@]6([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]55C7=C(C([H])=C([H])C(O[H])=C7O[C@]45[H])C6([H])[H])C([H])([H])C([H])([H])[C@]4(O[H])[C@@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]34C2=C(C([H])=C1[H])C5([H])[H]
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[H]N(C(=O)N([H])C1([H])C([H])([H])OC1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C([H])([H])[H])=C2C(=N1)C(OC2([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=C(C(=O)C([H])([H])[H])C(=NN(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C12)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])O1
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[H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]N(C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C1=NC([H])=NC2=C([H])C(Cl)=C([H])C([H])=C12
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[H]N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])[H]
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[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2\C([H])=C2/SC(=O)N([H])C2=O)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C(O[H])C([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H]
[H]N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C3=NC(=C([H])C([H])=C23)C(F)(F)F)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=O
[H]N1C([H])([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C(C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1F)C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C(N([H])C([H])([H])C1=C([H])N([H])C2=C1N=C([H])N([H])C2=O)(C([H])([H])O[H])C([H])([H])O[H]
[H]N(C(=O)C1=NN(C2=C1C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(F)=C([H])C([H])=C1[H])[N+]([O-])=O
[H]C1=C([H])N2C(=C1[H])C(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C21)(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)C1=C(O[H])C2=C(C([H])=C([H])C(=C2[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C2=C(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C(=O)[C@]([H])(C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(N([H])C([H])([H])[H])=C([H])C(N([H])C([H])([H])[H])=C1[H]
[H]C1=C([H])C2=C(O1)C(=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]OC(=O)[C@@]([H])(N([H])[H])C1=C([H])C(O[H])=NO1
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[H]N(C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C1=NOC(=C1[H])C([H])([H])[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=C(C(=O)C2=C(O1)C([H])=C1OC(C([H])=C([H])C1=C2O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1C(=O)C2=C([H])C(OC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N([H])C(=O)C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])S1)C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H]
OB(O)C1=CC(=CC=C1)C#N
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C(C(=O)N([H])C2=O)C([H])([H])[H])C([H])([H])[C@]1([H])N=[N+]=[N-]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=C(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])SC(=C1[H])C(=N[H])N([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])N(C3=NC([H])=C4C([H])=C([H])C(F)=C([H])C4=N3)C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NOC(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@](C(=O)O[C@]1([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N([H])C2=C3N=C4C([H])=C([H])C(Cl)=C([H])C4=C3C([H])([H])C([H])([H])C2=C1[H]
[H]N(C([H])([H])[C@@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3N([H])C2=C1C([H])=C([H])C(F)=C2[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]C1=C(N=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC2(C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C(=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(N([H])C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C(SC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])=C2C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C1=C23
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])=C4C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@]4(C([H])=O)[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
CC1=CC(N[C@H](CCCCNCCCC2=CC=C(F)C=C2)C(=O)NO)=CC(C)=C1F
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C2=NC3=C([H])C(OC([H])([H])[H])=C([H])C(=C3C(=O)O2)C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC2=C([H])C(OC([H])([H])[H])=C(C#N)C([H])=C2[H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(Cl)=C(N([H])C2=NC3=C(S2)N=C([H])N=C3N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(Cl)=C1[H]
[H]N(C(=O)C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H])C(F)=C1[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C(F)C([H])=C([H])C(F)=C1[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C3=C2C2=C([H])C([H])=C([H])C([H])=C2N3C([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
OC1=C(Cl)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C2=C1N=C(N2C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])C1=NC([H])=C(Cl)N=C1C([H])([H])N([H])C(=S)N([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1F)C1=C2C(=C(N1[H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C([H])C2=C(OC1=O)C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C(=O)N([H])C(C(=O)OC([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(SC2=C3C([H])([H])C([H])([H])[C@@]4([H])[C@]5([H])C([H])([H])C([H])([H])C(=O)[C@]5(C([H])([H])[H])C([H])([H])C([H])([H])[C@]4([H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])C2=O)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=NO1)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C([H])C(O[H])=C(O[H])C(Cl)=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N1C(SC([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(SC(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N2C1=NC([H])=C2C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])[N+]([O-])=O
[H]N(C(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC(=C([H])C([H])=N2)N(C(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(N=C1C([H])([H])[H])N(C([H])=C(C(=O)OC([H])([H])C(=O)O[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=O)C([H])([H])C([H])([H])[H]
CNC(=O)\C=C1\COC2=CC(OS(=O)(=O)C3=CC=C(Cl)S3)=CC=C12
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)[C@@]([H])(N1C(=O)[C@@]([H])(N2C(=O)OC([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NN([H])N=N2)=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])N(C(=N1)[C@@]([H])(N(C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)[C@]1([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C2=C(N=C3C4=C([H])C5=C(C(=O)N4C([H])([H])C3=C2[H])C([H])([H])OC(=O)[C@]5(O[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N1C([H])([H])C1([H])[H]
COC1=CC=C(OC2=CC=C(CN(CC3=CC(F)=CC(F)=C3)C3=C(Br)C=C(CC(O)=O)C=C3Br)C=C2)C(OC)=C1
[H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C4OC([H])([H])C([H])([H])OC4=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=NC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4N=NC([H])=C4[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1O2
[H]ON([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])N(C(=O)C2=C(N=NS2)C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C(=C(N([H])C2=C(C([H])=NC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C23)C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C(N([H])C(=O)\C2=C(\[H])C2=C(OC([H])([H])[H])C([H])=C([H])N2[H])=C([H])C([H])=C1[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1Br)C([H])([H])C(=O)OC([H])([H])[H])C1=C(C2=C([H])C(=C([H])C([H])=C2N1[H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C([H])=C1C1=NC([H])([H])C2=C1C(OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NC([H])=C2[H])C([H])([H])C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C(=NN1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1O[H])[C@]1([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])[C@]([H])(O2)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C(C2=NSN=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H]
[H]OC1=C2N([H])C(=O)C([H])=C([H])C2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C2=O)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=C(C2=C(N=C([H])N=C12)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N(C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=O)O[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(\C([H])=C3/SC(=S)N(C3=O)C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(=O)C([H])=C(O1)C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C([O-])=O
[H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]N1N=NC(=N1)[C@@]1([H])OC2=C([H])C(OC([H])([H])C3=C([H])C(OC([H])([H])C4=NC5=C([H])C([H])=C([H])C([H])=C5C([H])=C4[H])=C([H])C([H])=C3[H])=C([H])C([H])=C2C(=O)C1([H])[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])OC2=C(N=C(C([H])=C2[H])C([H])([H])[H])[N+]([O-])=O)=C(Br)C([H])=C1Cl
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])N([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(O[H])=C(O[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C(=S)N(C(=O)\C1=C(/[H])C1=C([H])C(=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])SC([H])([H])[C@]([H])(N([H])C1=O)C(=O)O[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
COC1=CC=C2C(SC3=C2N=CN=C3NC2=CC=C3OCCOC3=C2)=C1
[H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])\C(=N\OC([H])([H])C([H])([H])[H])N([H])C1=O
[H]N(C(=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC1=NC(=C([H])S1)C([H])([H])SC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])[C@]2([H])N=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])[H])=C1[H])N([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
O\N=C(/CC1=CC(OC2=C(Br)C=C(CCNC(=O)C(\CC3=CC(Br)=C(O)C(=C3)C3=C(O)C(Br)=CC(C\C(=N/O)C(=O)NCCC4=CC(Br)=C(O)C=C4)=C3)=N\O)C=C2)=C(O)C(Br)=C1)C(=O)NCCC1=CC(Br)=C(O)C=C1
[H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)S2)[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C1[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(I)C([H])=C3[H])C([H])([H])C1([H])[H])=NC1=C(F)C([H])=C([H])C([H])=C21
[H]C1=C(ON=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=C(C#N)N2C(\C1=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])=C(S[C@]([H])(C2=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N1C(=O)C([H])=C(C2=C1C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N([H])C1=C(C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C([H])=NN1C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C(\[H])=C1/[C@@]2([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]1(N([H])[H])C1=C(N([H])C(=O)C([H])=C1[H])C2([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1C(OC([H])([H])[H])=NC2=C1N=C(N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(F)(F)C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])\C([H])=C([H])\C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C(C#N)=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]C1=NN(C([H])=N1)[C@]([H])(C1=C([H])C2=C(O1)C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N1C([H])=C(C(=O)[C@@]2([H])N([H])[C@]([H])(SC2([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C([H])([H])N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C3C(=O)C4=C(N([H])N=C4C3=C([H])C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C(=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(Cl)C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=NC2=C(N=C(N=C2N=C1[H])N([H])[H])N([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])[H])=C(N([H])C3=NC([H])=C(C(=N3)N([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])=C2C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]C1=C([H])C(=C([H])C(F)=C1F)C(=O)C#CC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2SC([H])=C(C2=C1[H])C1(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C([H])=[N+](C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC1([H])[H]
CC[C@@H](CO)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](COC(=O)OC(C)C)c1cccc(Cl)c1
[H]C([H])=C([H])C([H])([H])C1=C([H])C2=C(OC(=C2[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C([H])N2C(Br)=C(N=C2C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]\C(=C(\[H])C(=O)OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C(=O)OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
[H]OC1=C([H])C(O[H])=C2C(OC(=O)C(N3C([H])([H])C([H])([H])N(C(=O)N([H])C4=C([H])C([H])=C(C([H])=C4[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2C([H])([H])[H])=C1[H]
COC[C@H](C)OC1=CC(\C=C\C2=CC=CC(=C2)[N+]([O-])=O)=CC(=C1)C(=O)NC1=NN(C)C=C1
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])[C@]1([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1N=C(C([H])=C([H])C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C(=O)[C@]([H])(C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=C(Br)C([H])=C([H])C([H])=C2\C([H])=C2/SC(=O)N([H])C2=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=O)C2(O1)C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N(C([H])([H])C([O-])=O)C([H])([H])C([O-])=O)=C1[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=NC([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N(C(=O)[C@@]([H])(N1C(=O)C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC(=NC2=C1C([H])=C([H])C([H])=C2[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CN1C(N)=NC2(CC(C)(C)SC3=C2C=C(C=C3)C2=CN=CN=C2)C1=O
[H]ON(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(\C(=N/C#N)N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC(=N2)C([H])([H])[H])C([H])=C1[H]
[H]C1=C(N(C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2OC(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=NN(C2=NC(=N1)C1=C([H])C([H])=C([H])C2=NN([H])C([H])=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=C(C2=C1N=C([H])N=C2N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]\C(=C1/C(=O)C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C(N([H])C(=N1)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(SC2=C([H])C([H])=C(C([H])=C2[H])N(C(=O)C([H])([H])[H])C([H])([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C2C(OC(=C2C(=O)C2=C([H])C(I)=C(C(I)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C(=O)N(C2=NOC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2=C([H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H]
[H]C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(C2=C([H])C([H])=C3C([H])=C(C([H])=C([H])C3=N2)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])=C(N=C1C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])C1([H])C([H])([H])C(=O)N([H])C(=O)C1([H])[H])[C@]1([H])C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])[C@](O[H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(C([H])=C2C(=O)C([H])([H])[H])C(=O)C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3F)C([H])([H])[H])=C(C([H])=N2)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C([H])C(C2=O)=C13
[H]N([H])C1=NC(=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]23[H])C([H])([H])[H])C1([H])[H]
[H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[C@]([H])(Br)C([H])([H])[H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)[C@]2([H])ON(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(O[H])C([H])=C3[H])[C@]2([H])C1=O
[H]N(C1=C([H])C([H])=C(Br)C(Br)=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H]
[H]OC1=C(C2=C(O[C@@](C([H])([H])[H])(C([H])([H])OC3=NO[N+]([O-])=C3S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(=NC(=C1C#N)C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2F)C([H])([H])C2=NN([H])C(=O)C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
COC1=CC(=CC(OC)=C1OC)C1=C(CNC1=O)C1=CN(COCC[Si](C)(C)C)C2=C1C=CC=C2
[H]N1C(=O)N([H])C(=O)C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=NC(=C([H])O3)C3=C([H])C([H])=C([H])C([H])=N3)C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]N(C1=C(C([H])=C(C([H])=N1)C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])OC1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C1=C([H])N(N=N1)[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NC(=N2)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C#C[H])N2C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N3N=NC(=C3[H])[C@@]([H])(N([H])[H])C([H])([H])C3=C([H])C([H])=C(O[H])C([H])=C3[H])C([H])([H])C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4N3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])=C([H])C([H])=C2C([H])([H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N1C(=S)N(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C(F)=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C(=O)N([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C#N)(C2=C([H])C([H])=C(F)C([H])=C2C#N)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2[C@]([H])(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])F
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C5=C([H])C([H])=C([H])C(=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3N=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(C#N)C([H])=C1F
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C([H])C([H])=C1C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])[C@@](C1=C([H])N(N=N1)[C@]([H])(C(=O)C([H])([H])OC1=C(F)C(F)=C([H])C(F)=C1F)C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC1=C2N(N=C(C2=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])\C(=N\C(\S[H])=N\C([H])([H])C([H])([H])C([H])([H])OC(=O)[C@@]2([H])N(C(=O)C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C([H])C1=C1C2=C(OC3=C1C([H])=C([H])C(O[H])=C3[H])C([H])=C(O[H])C([H])=C2[H]
[H]N(C(=O)N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
C1CC(CCO1)NC1=CC(=CC=N1)N1C2=C(C=CC=C2)N=C1C1=CC2=CC=CC=C2C=C1
[H]N(C1=C2C([H])=NN(C2=NC([H])=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(S1)N(N=C2C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(C([H])=C(N([H])C1=O)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]C1=C(N=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N(C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N=C(N([H])C1=C([H])C([H])=C2C([H])=C([H])N(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1
[H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C3=C(C([H])=C12)N(C(=O)O3)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(N(C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(=C([H])N=C12)C1=NC(=C([H])C(=N1)C([H])([H])S(=O)(=O)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(C(C#N)=C2N1C(=O)C(=C([H])N2C([H])([H])C1=C(C#N)C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])C([H])=C([H])C([H])=N1
[H]C1=C([H])C(=C([H])C([H])=C1[C@]1([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C(OC(=O)C([H])([H])C([H])([H])[H])=C1[H])C(F)(F)F)C(F)(F)F
[H]N(C(=O)[C@@]1([H])N([H])C([H])([H])[C@@]([H])(N([H])C1([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C1=NC2=C(F)C([H])=C(F)C([H])=C2S1
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[H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]N(C1=C([H])C([H])=C2C(=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]O[C@@](C#C[C@@]1(OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=NN=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(Br)C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C2([H])[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=NN1C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C2N(C(=O)N(\C1=N\C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])[H])C(F)=C1[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])[H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])N3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C(=O)N([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C(O[H])C([H])=C3O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C([H])([H])C3=O)C([H])=C1[H])C([H])([H])C([H])([H])O2
[H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3OC([H])([H])[H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
OC(=O)[C@H]1CC[C@@H](CC1)OC[C@@H]1C[C@H](F)CN1C(=O)CC1=C(F)C=C(NC(=O)C2=NNC3=C2C=CC=C3)C(Cl)=C1
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])=C2N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(OC([H])([H])C4=C([H])C([H])=NC([H])=C4[H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=O)N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N2C(=N1)N=C(C([H])=C2N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
CN(C)CCCOC1=NC2=C(CCN(C)C2)S1
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])N=NN=N1)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(O[H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C(O[H])=C1[H]
[H]N([H])C1=C([H])C2=C(C([H])=N1)C(=NC([H])=N2)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])N2S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(F)C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])([H])OC([H])([H])C([H])([H])C1=C(N(OC1=O)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C#CC([H])([H])N(C(=O)[C@@]1(C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(F)(=O)=O
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C4N([H])C([H])([H])C([H])([H])C4=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]SC([H])([H])C([H])([H])C(=O)\N=C1\SC(=NN1C([H])([H])[H])S(=O)(=O)N([H])[H]
[H]N([H])C1=NC([H])=NC2=C1N=C(SC1=C(I)C([H])=C([H])C(OC([H])([H])[H])=C1[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(=NN2C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(SC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O1)C(=C(O[H])C([H])=C2O[H])C1=C(OC2=C([H])C(O[H])=C([H])C(O[H])=C2C1=O)C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C(I)C3=C2N=C([H])N=C3N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[C@]2([H])C(=C([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N1C([H])=NC2=C1C([H])=C([H])C(C#N)=C2[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])N3C([H])([H])C([H])([H])C([H])([H])S3(=O)=O)C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C1[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(I)C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])[C@@]1([H])O[C@]([H])(OC([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]1([H])OC(=O)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(OC2=C(N([H])[H])C([H])=C([H])C(OC3=C([H])C(=C([H])C([H])=C3[H])C(=N[H])N([H])[H])=N2)=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(\N=C(/N([H])C#N)N([H])C2=C([H])C([H])=C3C(=C2[H])N(C2=NC(=C([H])S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=NN1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(C2=C(N([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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[H]N1C2=C([H])C3=C(C([H])=C2C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1F)C3=O
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[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1OC(C1=C([H])C([H])=C([H])C([H])=C1[H])=C(C2=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC([H])([H])[H])N2C(=N1)N(C(=O)[C@@]2(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]C1=C([H])C(=C([H])C(SC([H])([H])[H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])SC2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(S1)[C@]1([H])C(C#N)=C2SC([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N2C(=O)C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(O[H])(C1=C([H])C(=C([H])N=C1[H])C1=C(C([H])=C([H])S1)C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C2([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])C([H])([H])[H])C(=N1)C1([H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1=NN([H])N=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NC([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])OC1=NC([H])=NC(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
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[H]N(C(=O)C1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1=C([H])C(=NN1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C#CC([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=NC([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
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[H]N1C([H])([H])C2=C(N(C3=C([H])C(=C([H])C([H])=C23)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C2=O)C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]O[C@@](C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])[H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C(N([H])C2=C3C([H])=NN(C3=NC([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
CS(=O)(=O)CCNC(=O)C1=CC2=C(NCC1)N=CN=C2NC1=CC(Cl)=C(OC2=CC=CC3=C2C=CS3)C=C1
[H]C1=C(F)OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])[N+]([O-])=O
[H]N(C1=C2C(=NN1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=NC2=C(N=C1[H])N=C(N=C2N([H])[H])N([H])[H])C([H])([H])N([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C1=NN=C2SC([H])([H])C(=NN12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C(OC([H])([H])C2([H])[H])C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N1C(=O)N(C2=C(C([H])=C([H])N=C2[H])C1=O)C([H])([H])C1=C([H])N(C2=C1C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O)S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])N1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@](C(=O)N4C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C4([H])[H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])[C@@]21[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)O[C@]1([H])[C@]([H])(C2=C(F)C(=C(F)C([H])=C2N([H])C1(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1N([H])C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=NON=C3N=C2N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=NN=C1C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=NC(=C1[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2N([H])N=NC2=C1[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(Br)=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]\C(=C1\C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])[H])C1=[N+](C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(N([H])[C@@]([H])(C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(N([H])[H])=C2[H])C2=C(F)C(OC([H])([H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])=C([H])C([H])=C1C(=N[H])N([H])[H]
[H]N1C2=C(N=NN2C2=C([H])C(=C([H])C([H])=C2C1=O)C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C([H])C([H])=C(C([H])=C2C1([H])[H])[C@@]([H])(N1C([H])([H])[C@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(O[H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=NC([H])=C([H])S2)=NN=C1C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C([H])([H])C1=C(N=C(O1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])=C2O[C@]1([H])C(F)(F)F
[H]\C(=C(\[H])C([H])([H])OC(=O)[C@]1([H])N(C(=O)C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]O[C@](C1=C([H])C2=C([H])C(C#N)=C(C([H])=C2N1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C(=C([H])C(OC([H])([H])[H])=C3[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=N2)C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1CC1)C1=C(F)C=CC=C1
CN1C=C(C=N1)C1=CC(F)=C(CN2C(=O)COC3=C2C=CC=C3)C=C1
[H]N([H])C1=NC(N([H])[H])=C2C(OC([H])=C2C([H])([H])N([H])C2=C([H])C([H])=C3N(C4=C(C([H])=C([H])C([H])=C4[H])C3=C2[H])C([H])([H])C([H])([H])[H])=N1
[H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C(=C2C(=O)O1)C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(N([H])C([H])([H])C3=C([H])N([H])C([H])=N3)C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=C(N2N=C([H])C([H])=C2[H])C(=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])C([H])(C1=C([H])C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C(=O)O[H]
[H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)ON2[C@@]3([H])C([H])([H])[C@@]4([H])C([H])([H])[C@]2([H])C([H])([H])[C@@]([H])(C3([H])[H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C(F)=C(Cl)C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]C1=C(C2=C(O1)C([H])=C1C(=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C(=O)N2C(SC3=C([H])C([H])=C([H])C([H])=C23)=N1
[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])[C@]2([H])O[C@]([H])(O[C@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN2C(=NC(=C2C([H])=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
NC1(CC1)C1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1
[H]N(C(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C(C([H])=C1[H])N1C(=O)C2=C(OC([H])([H])C([H])([H])[H])C3=C([H])C([H])=C([H])N=C3C(OC([H])([H])C([H])([H])[H])=C2C1([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C2C(OC([H])([H])[C@]([H])(C3=C([H])C4=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C4(C([H])([H])[H])C([H])([H])[H])C2([H])[H])=C1[H]
[H]N1C2=C(C3=C(N=C([H])C([H])=C3[H])C([H])=C2[H])C2=C(C(=O)C([H])([H])C([H])([H])C2([H])[H])[C@@]1([H])C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=O)[C@](O1)(C1=C([H])C(Br)=C(S1)C([H])([H])[H])C([H])([H])[H]
[H]C1=C(Br)C([H])=C2C(=N1)[C@]([H])(C1=C(C(Br)=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=[N+]([O-])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(SC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C2N(C(=NC2=C1C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2(C1=O)C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2N=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C2(OC([H])([H])C([H])([H])O2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@](N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC1=C2N([H])C([H])=C(C2=NC(=N1)N([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C2N=C3C(C([H])=C([H])C([H])=C3OC([H])([H])[H])=C2C([H])=C(N1C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=S)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(F)(F)F)C([H])=C2[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]([H])(C1=NC([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[C@@]1([H])ON=C(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C(=C([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N([H])C1=O)C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=NN=NN1[H])(C(F)(F)F)C(F)(F)F
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=NC(=C1[H])C([H])([H])O[C@]1([H])O[C@]([H])(C([H])([H])OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H]
[H]C1=C([H])C([H])=C2C(C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2C(=C2C(=NC([H])=C([H])C2=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N=C(SC2=C1[H])C(=O)C1=C([H])C([H])=C([H])C(O[H])=C1F
[H]N(C1=NC2=C(S1)N=C([H])N=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C(Cl)C([H])=C(C([H])=C1Cl)C(=O)OC([H])([H])[H]
[H]OC([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C(Cl)C([H])=C(\C([H])=C2/S\C(=N/C([H])([H])C([H])([H])C([H])([H])[H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)N2[C@]([H])(SC([H])([H])[C@@]12[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H]
[H]\C(=C(\[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C(=NS1)C([H])([H])[H])C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])S(=O)(=O)C([H])([H])[H]
[H]ON([H])C(=O)[C@](N([H])[H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C([H])([H])C([H])(OC2=C(OC3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C([H])C([H])=C2F)C1([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C1=NN=C(O1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CN(C)CCNC(=O)C1=C(C)N(C(=C1)C1=CC=CC=C1)C1=CC=C(C=C1)S(N)(=O)=O
[H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN=C(O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC(=O)N(C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C(Br)C([H])=C3[H])=C([H])C([H])=C2O1
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(/C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])[C@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(OC([H])([H])C([H])([H])C2([H])[H])=NC2=C1C([H])([H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)[C@@]([H])(C([H])([H])O[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N([H])C(=O)C([H])([H])N1C([H])=C(C(=O)[C@@]2([H])N([H])[C@]([H])(SC2([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]ON1C2=C(C(=NN2C([H])([H])[H])C(F)(F)F)C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=C(N(C(=C1C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])=C([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=NC(=C([H])S1)C(=N[H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(C#N)C([H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(C(=O)N([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(O1)C1=NN(C(=O)C([H])([H])C([H])([H])[H])C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=N1
[H]SC1=NN=C(S1)N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])C1(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(N([H])[H])C(=O)N1[C@@]2([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]1([H])C#N
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=NC(=C1\C([H])=C(\C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[Fe]123456789C%10C1=C2C3=C4%10.N(CCCCN1CCN(CC1)C1=CC=CC=C1OC)C(C51C6=C7C8=C91)=O
[H]C1=C([H])C(F)=C(C([H])=C1[H])C1(C2=NN=C3N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OP([O-])(=O)[C@]([H])(C([H])([H])[S@+](C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])P(=O)(O[H])O[H]
[H]C1=C(C(=O)N2C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C3=C2N1[C@@]([H])(C([H])([H])O3)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])O[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC(=NC(=C2C([H])([H])C([H])=C([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1N=C2N(C1=O)C(=NC(=C2C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1(N([H])S(=O)(=O)N2C([H])([H])C3=NN4C([H])=C(F)C([H])=C([H])C4=C3C([H])([H])C2([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[H]
[H]N([H])C1=C(C(=NC([H])=N1)C#CC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@@]([H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=O
[H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)(F)F
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])SC2=C([H])C(O[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1\C([H])=C(/[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)C(=N/OC([H])([H])C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(Cl)C([H])=[N+]([O-])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])N2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]N(N1C(SC([H])([H])SC2=NN=C(N2N([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C(SC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N1N=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])OC2=C3OC([H])([H])C(=C([H])C3=C([H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])[H])N2N=NC(=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C(OP([O-])(=O)OC([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
NCCC1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O
[H]C([H])([H])[C@]([H])(C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])[C@]([H])(OS([O-])(=O)=O)[C@@]4([H])C([H])([H])[C@]([H])(OS([O-])(=O)=O)[C@]([H])(OS([O-])(=O)=O)C([H])([H])[C@]4(C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]\C(=C(/[H])[N+]([O-])=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(O1)C(=O)OC([H])([H])[H]
[H]N(C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC([H])=NC2=C1SC([H])=C2[H]
[H]N1C([H])([H])C([H])([H])O[C@@]([H])(C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1I)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=NC2=C1N=NN2C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N1N=NN=C1C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=NC(=C([H])N1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2[H])C([H])([H])C1=NC2=C(N=C(N=C2N=C1[H])N([H])[H])N([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H]
[H]N([H])C1=NON=C1N1N=NC(C2=NN([H])C(=N2)C2=C([H])C([H])=NC([H])=C2[H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=C(Cl)C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N1)C([H])([H])[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C(\C#N)=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C([H])C2=C(OC(=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]N(C1=NN=C(O1)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1OC([H])([H])[H])C(=C([H])N2[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]OC(=O)C1=C([H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@]([H])(O[C@@]2([H])C([H])=C([H])[C@@]3([H])[C@]4([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]33C5=C(C([H])=C([H])C(O[H])=C5O[C@@]23[H])C4([H])[H])O1
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(I)C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N(N(C#N)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)O[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(/C1=C([H])C(=C([H])C(=C1OC([H])([H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]23[H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])N2C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[S@](=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])N2C2=C1C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(O[H])(C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(\C([H])=C2/C(=O)/C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=C2C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C2=NC([H])=N1)C1=C(Cl)N=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(OC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C4=C([H])C([H])=C([H])C(C#N)=C4[H])C([H])([H])[C@]3([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N1C(=NN=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])N=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]C1=NC(=C(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]4(C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])N(C(=O)C5([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C4([H])[H])C([H])([H])[C@@]3([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])SC2=C1[H]
[H]OC(=O)C1(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])C3([H])[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NN(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C(=O)[C@]1([H])N2C(=O)[C@]([H])(N3C(=O)[C@@]4([H])N(C(=O)C3([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[C@@]2([H])SC1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C2N=C([H])N(C2=NC([H])=N1)[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(S\C1=N/C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])[N@+](C([H])=N1)(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(OC([H])([H])[H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H]
[H]O[C@]1([H])[C@@]([H])(OC(=S)N(C([H])([H])[H])C([H])([H])[H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@@]2([H])[C@@]2([H])S[C@@]32[H])[C@]1([H])O[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[H])N([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=NC([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)[N+]([O-])=O
N=C(NCCCN(CCCCN(CCCNC(=N)NC1=CC=CC=C1)C(=N)NC1=CC=CC=C1)C(=N)NC1=CC=CC=C1)NC1=CC=CC=C1
[H]N([H])C1=C(C(=O)C([H])([H])[H])C(=O)N(C2=C1C([H])=C(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=N2)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]N1C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC([H])([H])C([H])([H])[H])[C@@]2(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C2N(C3=C(C2=C([H])C(Cl)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C1=C(Br)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)(=N[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F
CC1=C(NC(=O)NC2=CC=CC(=C2)C2=CSC3=C(C=NC(N)=C23)C2=CN=CC=C2)C(C)=NO1
[H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=NC([H])=C2[H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N(C([H])([H])[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(N([H])C2=C3N=C([H])N([H])C3=NC(=N2)N([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(N=C2[H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1(C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N1C([H])=C(C2=C1C([H])=C([H])C(Br)=C2[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=NON=C23)[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@]([H])(O[C@]2([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@@](OC([H])([H])[H])(C([H])([H])[H])C3([H])[H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(C3=C(C([H])([H])[H])C([H])([H])[C@]2(O3)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H]
[H]ON([H])C(=O)[C@@]([H])(OC([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N=C2[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N=C(C([H])=C2C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])[C@]2([H])OC([H])([H])[C@@]1([H])C2([H])[H]
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])S\C(=N/C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])N1C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]N([H])N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(OC2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H]
[H]N1N(C(=O)\C(=C(/[H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C2[H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(Cl)C([H])=C2[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C([H])C2=C(N=C([H])N=C12)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=N1
[H]N(C(=O)C1=C(F)C([H])=C2C(=O)C3=C(N([H])C2=C1[H])C([H])=C([H])C([H])=C3[H])C(C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(\Cl)=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(F)(F)F
CC1=NN(C(NC2=CC=C(C)C=C2C(O)=O)=C1C1=CC2=NC=CN=C2C=C1)C1=C(C)C=CC=C1
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])S1)C(=N[H])N([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C1([H])[H])N=N2
[H]N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C1=C(N=C2N1C([H])=C(Cl)C([H])=C2Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]ON(C([H])=O)[C@@](C([H])([H])[H])(C([H])([H])[C@@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C(C([H])=C(F)C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])N=C3C(=N2)C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC2=C1N([H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=NN3C([H])=C([H])C([H])=C3C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@](C(=O)OC([H])([H])[H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])[H])C#CC1=C([H])C([H])=C([H])C(N([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)C(\[H])=C(/[H])C1=C([H])C(Br)=C(O[H])C([H])=C1OC([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C(N=C(S2)N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C(=N1)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl
[H]C([H])=C([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])N=C(N=C12)N([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])N(C([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N(C(=O)C1=C(N([H])C2=C(C([H])=C(Br)C([H])=C2[H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])C(=N/C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)\N([H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])N([H])C(=O)C([H])([H])[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)N([H])C([H])([H])C(N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(Br)C([H])=C12
[H]C1=NN(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(OC(=O)[C@@]1([H])N(C(=O)[C@]([H])(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=NC(=C([H])C(OC([H])([H])[H])=N1)N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C(=NC2=C3C([H])=C(Cl)C([H])=C([H])C3=C3C([H])=C([H])C([H])=C([H])C3=C12)C1=C(F)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])=NC3=C([H])N=C4N([H])C([H])=C([H])C4=C23)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=N2)C1=O
[H]N(C1=NC2=C([H])C(=C(C([H])=C2N=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])N=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)N(C1=O)[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(OC1=C([H])C(N([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([H])([H])[H])=C2N=C([H])N(C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(F)=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([C@@]1([H])C([H])([H])N(C#N)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@](O[H])(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC(=O)C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N=C(SC([H])([H])[H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]\C(=C1\C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C(\[H])=C(/[H])C1=C(N(N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C(=N1)N([H])[H]
[H]N1C2=C([H])C([H])=C(N=C=S)C([H])=C2C(C(=O)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[S+]([O-])(=NC(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(OC(=O)[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])=C([H])[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])SC2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)[C@@]([H])(N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC(=NC2=C1N=NN2C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]