[H]N=C(N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(Br)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/[H])C2=C(N=C(S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C3=NC4=C(S3)C([H])=C([H])C([H])=C4OC([H])([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(OC2=NC([H])=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])=C1[H] [H]N(C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C([H])O1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)[C@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])SC([H])([H])C([H])([H])N1C(=O)C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(N([H])[H])=C1[H])C2([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])S1 [H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=C(SC(=N2)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1S2(=O)=O)C([H])([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])SC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C1=NN([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=N1 [H]N1C(=S)N(C2=C1C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])[N+]([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=NOC(=C1[H])C1=C([H])C([H])=C(Cl)S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C([H])N=C1N1C(=C([H])C(C(=O)C([H])([H])SC2=NN=C(N2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C#CC([H])([H])N([H])[H])C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2F)=C([H])C([H])=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[C@]11C(=O)N([H])C(=O)N([H])C1=O)S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C1C([H])=C(S2)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1([H])OC([H])([H])C([H])([H])C([H])([H])O1)C1=C(C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])OC2=C(OC([H])([H])C([H])([H])[H])C([H])=C(C#N)C([H])=C2[H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])C1=C(N=C(N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]OC1=C([H])C(=C([H])C(O[H])=C1O[H])C(=O)OC([H])([H])[C@@]1([H])O[C@]([H])(OC(=O)C2=C([H])C(O[H])=C(O[H])C(O[H])=C2[H])[C@]([H])(OC(=O)C2=C([H])C(O[H])=C(O[H])C(O[H])=C2[H])[C@@]([H])(OC(=O)C2=C([H])C(O[H])=C(O[H])C(O[H])=C2[H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(O[H])C(O[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C4=C(C([H])=C3[H])C([H])([H])C(=O)C([H])=N4)[C@@]1([H])C2([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C(Cl)C(=N2)C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N4C(=NC([H])([H])C5(C4([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C(=O)C3=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N([H])C1=C(C([H])=C([H])C([H])=N1)[N+]([O-])=O [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])N1C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])N2C([H])=C1C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N(C(=C1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=NN(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C1=NN=C([H])N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC2=C([H])C([H])=C([H])N=C2[H])N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]C([H])=C([H])OC1=C([H])N=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)C4=C(C([H])=C(C([H])=C4C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@]2([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N3C2=NC([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(Cl)=C([H])C(Cl)=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C(I)C([H])=C([H])C([H])=C1[H])N([H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H][C@@]1(CCCCN1CC1=CC=CC=C1)[C@H](C(N)=O)C1=CC=CC=C1 [H]N([H])C1=NN=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C(F)(F)F [H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]C(=[N+]=[N-])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])N([H])C([H])=N1 [H]N([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C3C(=NC4=C(C([H])=C(OC([H])([H])[H])C([H])=C24)C([H])([H])[H])N([H])N=C3C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=NC([H])=C2[H])N([H])C2=NC3=C(S2)C([H])=C(C([H])=C3[H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2Cl)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]C([H])([H])N(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=NC3=C(O[H])C(=C([H])C([H])=C3C([H])=C2[H])C(=O)O[H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C(=C([H])N(C(=O)C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])C3=NC4=C(C([H])=N3)C([H])=C([H])C(OC([H])([H])[H])=C4C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(N([H])C2=NC(=C([H])C([H])=N2)C2=C(N=C(N2[H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C([H])C([H])=C2[H])=C1[H] [H]C([H])=C([H])C([H])([H])N1C(=NC(=O)C1(C([H])([H])[H])C([H])([H])[H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C(=O)N2N=C(C(=O)N2C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2OC1=O [H]C1=C([H])C([H])=C(O1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(SC([H])=C2[H])C([H])([H])N([H])C1([H])[H] CCCCN(CCCC)CCCC1=CC=C(C=C1)N(O)=O [H]OC(=O)[C@@]1([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])[C@]2([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(\[H])=C(\[H])/C(/[H])=C(\[H])/C(/[H])=C(\[H])[C@]([H])(O[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(F)(F)F [H]C1=C([H])C([H])=C2N(N=NC2=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(F)C([H])=C(F)C([H])=C3F)C([H])([H])C2([H])[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]N(\C(SC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)=N\C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N=C(N=C([H])C2=C1[H])N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C1=NN=NN1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])S[C@](C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=N[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]ON([H])C(=N[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])C(=O)O[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])(C(=O)O[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C3=C(C(=O)C([H])([H])[C@@]2([H])[C@]1([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])[C@@]1(C([H])([H])[H])[C@@]([H])(O[H])C3([H])[H])C([H])([H])[H] CCC1=NN2C(C=CC=C2C2=C(OC)C=C(CO)C=C2OC)=C1N(CC1CC1)CC1CCOCC1 [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C([H])=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1Cl)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]OC1=C(C([H])=C(OC2=C(Br)C([H])=C(C([H])=C2Br)C([H])([H])P(=O)(O[H])O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C2=C([H])C(O[H])=C(O[H])C([H])=C12 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C1=NC([H])=C(Br)N=C1OC([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])OC(=O)N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N1N=NC(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]C1=C(C(=O)C2=C(O1)C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C2=C1OC(=C([H])C2=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)N(S2)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=NN=C(N2C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=C(C([H])=NS1)C1=C([H])N=C2C([H])=C(C([H])=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N=C2C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]1([H])[C@]([H])(O[H])[C@]([H])(O[C@@]1([H])N1C([H])=C(Br)C(=O)N([H])C1=O)C([H])([H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])S[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2OC(=C(C3=C([H])N(N=N3)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C(C([H])=C3[H])[N+]([O-])=O)C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=O)C(OC3=C([H])C([H])=C(F)C([H])=C3[H])=C(OC2=C1O[H])C(F)(F)F [H]N([H])N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C2([H])[H])=NC2=C(C([H])=C([H])C(=C2[H])[N+]([O-])=O)C1=O [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H] [H]N([H])C(=S)N([H])\N=C(\C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F CC(OC1=CC=C([Se]CC2=C(C)N=C(S2)C2=CC=C(C=C2)C(F)(F)F)C=C1C)C(O)=O [H]O[C@@]1(\C([H])=C(/[H])C([H])([H])C(F)(F)C(F)(F)C(F)(F)F)C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C4[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])N([H])C3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C1=C([H])C(O[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])C(F)(F)F [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2N(C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])[H])C1=O [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])N(N=C1C(F)(F)F)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C(F)(F)F)C2([H])[H] [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=NO2)C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])N1N=C(OC([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(C#CC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(C2=C3N=C(C([H])=C(N(OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]C(=O)C1=C([H])C(OC([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C#N [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C(F)(C2=NC([H])=C(N2C([H])([H])C([H])([H])[H])C2=C([H])C(=NO2)C2=C(F)C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)N2C[C@H](CCCNC(N)=N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](CC2=CC=C(I)C=C2)NC(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC1=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=[N+]1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])S2)C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1N(C(=O)C([H])([H])F)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC1=C([H])C2=C(C(=O)C3=C(C(O[H])=C(O[H])C([H])=C3O2)C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(O[H])=C1C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N([H])C2=C([H])C(F)=C([H])C([H])=C2C1=O)[C@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])[H])C2([H])[H] [H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] [H]C1=C(C([H])=C(C(=C1[H])N(C1=NC(=NC(=N1)C([H])([H])[H])N(C([H])([H])C#N)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F)N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C([H])=NC(=N4)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C2=C([H])SC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])C([H])([H])C3=C12 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C(Br)=C2[H])C([H])([H])C2(C([H])([H])C2([H])[H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])SC([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C1=NC([H])=C([H])S1 [H]C1=C([H])C(=C([H])S1)C1=C(SC(=N1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@]2(OC(=O)C2=C([H])C([H])=C([H])O2)C(=O)C([H])([H])SC2=NC([H])=C([H])C([H])=N2)[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]12[H] [H]ON(C([H])=O)[C@]([H])([C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])S1)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] NC1=CC2=C(NC3=NNC=C3N=C2C2=CC=CC=C2Cl)C=C1 [H]OC1=C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)[C@]([H])(O1)C([H])([H])C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)=C2[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])[C@]1(C([H])([H])N([H])C2=O)C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C(=C([H])C(=O)N([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2Br)[C@]([H])(O[H])[C@]1([H])O[H] [H]C1=NC2=C(N=C(N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H] [H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]N(C(=O)C([H])([H])N1N=C(C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[C@@]([H])(N([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C1=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]\C(C1=C([H])C([H])=C(Cl)C([H])=C1[H])=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]OC(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C(C([H])=C1[H])C1=NOC(=N1)C1=C([H])C(=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])N=C(N=C1[H])N([H])C1=NN=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N(C(=O)[C@@]1([H])N(C(=O)[C@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C1(C(=O)N([H])N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H] [H]N=C(N([H])C([H])([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])O[C@]([H])(O[C@@]1([H])C1=C([H])N=C([H])C([H])=C1[H])C(OC1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])[N+]([O-])=O)(C([H])([H])[H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C(C([H])=O)=C(Cl)N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]N([H])S(=O)(=O)C1=C([H])C(Br)=C(N([H])SC(=S)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C3C(OC([H])([H])[C@]3([H])C([H])([H])C1([H])[H])=C([H])C([H])=C2OC([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(O[H])O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H] [H]N(C(=O)C([H])([H])OC1=NOC(=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C(OC([H])([H])[H])=C(OC3=NC([H])=C([H])N=C3[H])C2=C1[H] O=C(NC1=NC(=NC2=CN(N=C12)C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 [H]OC(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)O[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C(OC2=C([H])C(=O)N(C3=C2C([H])=NN3C2=C(F)C([H])=C([H])C(F)=C2[H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])N1C(=O)C2=C(C1=O)C1=C(N(C3=C1C([H])=C([H])C([H])=C3O[H])[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H])C1=C2C2=C(N1[H])C(O[H])=C([H])C([H])=C2[H] [H]C1=NC(Cl)=C([H])C(=N1)N(C(=O)C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C(=O)C([H])([H])OC([H])([H])[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)N2C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C2=O)C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F [H]N1C(OC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])=NC2=C(C1=O)C(=C([H])C(=O)O2)C([H])([H])C([H])([H])[H] [H][C@]12CNC(CCCC)c3cccc(Cc4c(O)c(O)ccc14)c23 [H]N(C(=O)C#CC([H])([H])N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H])C1=C([H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C(N([H])[H])=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] [H]N([C@@]1([H])C(=O)N(C2=C([H])C([H])=C(C([H])=C2F)N2N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C(C#N)C([H])=C([H])C(OC([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2OC1=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(S1)C1(OC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NC(=NS1)N1C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H] [H]N(C1=NC2=NN([H])C(=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)OC1=C([H])C([H])=C2C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])[C@@]1([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C2=C(C([H])=C([H])C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)=C2[H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])N(C2=NC(=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]N([H])C1=NC2=C(SC3=C([H])C(Cl)=C([H])C([H])=C23)C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] COC1=C(F)C2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)C(CN)N3CCC(CC(=O)OC(C)(C)C)C3)C2=O)C=C1 [H]OC1=C([H])C([H])=C(OC(=O)OC([H])([H])C2=C([H])[C@@]3([H])[C@@]4([H])O[C@@]5(O[C@@]4(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]3(O5)[C@]3([H])C([H])=C(C(=O)[C@@]3(O[H])C2([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])[H] [H]N([H])C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O)[C@@]1([H])C([H])([H])N(C(=O)OC([H])([H])C2([H])C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C([H])N2[H] [H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N(C(=O)C(=O)C3=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1 CC(OC1=CC=CC=C1)C(=O)NC1=CC=C2N=C(NC2=C1)C1=CC=NC=C1 [H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C([H])([H])[C@@](O[H])(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)OC2([H])[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])[C@@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C(N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])(N1C2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]([H])(C1=NC([H])=C(F)C([H])=C1[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(C1=NC2=C(N1[H])C([H])=C(C(F)=C2[H])C(F)(F)F)=C1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])N=C([H])C(=C1[H])C1=NC(=NC(N([H])C(=O)C([H])([H])[H])=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])OC(=N1)C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]N([H])C1=C([H])C(=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])SC2=NC([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C2C(O\C(=C(\[H])C3=C(N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=O)=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=NC([H])=C2C#N)C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C3=C(C([H])=C12)N(C(=O)O3)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(=NN1C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C(C([H])=C([H])C([H])=N2)C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])[N+](=C1[H])C([H])([H])[H] [H]C1=C([H])N(C(=N1)C([H])([H])C([H])([H])N1C([H])=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])O1)C([H])([H])N([H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([C@]1([H])C(=O)N(C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=C1[H] [H]N([H])C1=C(C2=NC(=C([H])S2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])=C([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=O)C2=C(O1)C(N([H])C(=O)C1=C([H])C3=C(C([H])=C([H])C(OC([H])([H])C4=NC5=C([H])C([H])=C([H])C([H])=C5C([H])=C4[H])=C3[H])C([H])=C1[H])=C([H])C([H])=C2[H] [H]C1=C(N(N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C(C#N)=C4[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)S2)[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]N([H])C1=NC(=NS1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@@]3([H])C([H])([H])N(C([H])([H])[C@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H] [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C(=O)N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]4([H])C3=O)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C(N(N=C1C([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(F)C([H])=C2F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C1=C([H])C(=NC(=N1)N([H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C1([H])[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]OC(=O)C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C(=O)O[C@]1([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC([H])=C([H])C([H])=N1 [H]C1=C([H])C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=NN(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C(=C([H])C(\C([H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(\C([H])=C(/[H])C3=C([H])C(C(=O)O[H])=C(O[H])C(=C3[H])C3=C([H])C([H])=C([H])O3)C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])O1 [H]\C(=C(/C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NO[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]([H])(C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C(=O)C(=C(/C([O-])=O)C1=C([H])C2=NSN=C2C([H])=C1[H])\C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C(=O)N(C(=S)N([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])C(=O)C2=C(O[H])C(O[H])=C(O[H])C(OC([H])([H])[H])=C2O1 [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N1C(SC([H])([H])C(=O)OC([H])([H])[H])=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]1([H])N([H])[C@]([H])(SC1([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N/OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])\C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=N2)C1([H])[H] [H]O[P@@](=O)(C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]N1N=C(C2=C(C1=O)C([H])([H])C([H])([H])C([H])([H])N2[H])C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(SC(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(=O)N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N=C(O1)C1=C(C([H])=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])N2C([H])=C([H])N=C2C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=NC(=C([H])C([H])=C2[H])C2=NC(=NC(N([H])C(=O)C([H])([H])[H])=C2[H])N2N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)[C@@]([H])(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[C@@]1(OO[C@@]2(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC(=O)C([H])([H])N1C([H])=NC2=C([H])C([H])=C([H])C([H])=C2C1=O)C1=C(C([H])=C([H])C(Cl)=C1[H])[N+]([O-])=O [H]C1=[N+](C([H])=C(S1)C([H])([H])[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(OC([H])(F)F)C(OC([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(N=C2C(=O)OC([H])([H])[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(SC([H])([H])[H])=NC(Cl)=C1C#N COC1=CC=C(C=C1)C(CCCN)(C1=CC=CC=C1)C1=CC=CC=C1 [H]C1=NC([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C2=C(N=C(N=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)N=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2OC2=C1C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=O)C3(C2=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C3([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C1=C(C#N)C(=NC2=C(C([H])=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=NC(=O)C([H])([H])S2)[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] C(N1CCCCC1)C1=CC2=CC=C(OC3=NC4=CC=CC=C4S3)C=C2O1 [H]N(C1=NC([H])=NC2=C1N=C([H])N2[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]C1=C([H])N2C(=C1[H])C(=NC1=C2C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C([H])C(OC([H])([H])[H])=C2O1 [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(O[H])C(O[H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=N1)C([H])=C(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C(Br)=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])N(C(=O)C1([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C2C(SC3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])N([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC1=C(C3=C(C([H])=C1[H])C(=NO3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H] [H]N([H])C([H])([H])C1=C(N2N=C(C([H])=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])O1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]C1=NC(Cl)=C(Cl)N1C([H])([H])C1=C([H])C2=C(N=C(N=C2[H])C#N)N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1\C([H])=N\N([H])C(=S)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(O2)C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(C(=O)O[C@]1(O[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC(=O)N([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(=N2)N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C2([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C(SC([H])=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])=NC([H])=N1 [H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(O[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] O=C1NC2=C(C=CC=C2)N1C1CCN(CC2=CC=C(C=C2)C2=NN=C3N2C2=CC=CC=C2NC2=C3C=CC=C2)CC1 [H]OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C([H])([H])N(C(=O)[C@@]([H])(C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(Cl)C([H])=C(C([H])=C1Cl)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC(=C([H])C2=C1C(=O)OC1=C([H])C([H])=C([H])C([H])=C21)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N1C(=O)C2=C([H])C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N([H])C(=O)C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C3C([H])=C([H])C([H])=C([H])C3=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(OC2=C([H])C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])=C(C([H])=C2C(F)(F)F)[N+]([O-])=O)=C1[H] [H]N([H])C(=S)N([H])\N=C(/C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=NC2=C(OC(=N2)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C([H])S2)C2=C([H])C([H])=C([H])C(F)=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C(F)C(F)=C(F)C(F)=C2F)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])([H])C([H])([H])C([H])([H])N2[H])=C([H])C(O[H])=C1[H])C1=C([H])C(Cl)=C([H])C(I)=C1O[H] [H]N=C(N([H])[H])N([H])C(=O)C([H])([H])N1C(=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@@]2([H])SC([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C2OC(=C([H])C(=O)C2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(C3=NC(=NS3)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(C#N)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C(O[H])C([H])=C3C(OC4=C3C([H])=C([H])C([H])=C4[H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N=C2N(C(=NC2=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@]2(SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])N([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C2N([H])C(=O)C([H])([H])OC2=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=NC2=C(N1[H])C([H])=C(C([H])=C2[H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1C([H])([H])[H])C([H])([H])C(=O)N([H])N([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])C(=NN3C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N/C(=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[N+]1=C(C([H])=C(\C([H])=C(/[H])C2=C([H])C3=C4N(C([H])([H])C([H])([H])C([H])([H])C4=C2[H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])\N([H])[H] [H]N1N=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3C([H])([H])OC([H])([H])[H])C2=C([H])C(=C([H])N=C12)C1=C([H])N=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C(Cl)SC(Cl)=C21)C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C(=NC2([H])[H])C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(O[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])=N1 [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C1=NC(=NO1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=S)N([H])[C@]([H])(C([H])=C1[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C3C([H])=C(SC3=C([H])N=C2[H])C(=O)N([H])[H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]S\C(=N\C1=C([H])C([H])=C(C#N)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C1([H])[H])C([H])([H])OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C(\C([H])=C(\[H])I)=C([H])C([H])=C1[H])C2([H])[H] [H]\C(=C1\S\C(=N/C([H])([H])[H])N(C1=O)C([H])([H])[H])C1=C(N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N1C(=O)C([H])([H])OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])N2C(=C([H])C([H])=C2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])=C([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C(Cl)C(=C([H])S1)C(=N[H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(C(=O)OC([H])([H])[H])=C2C(OC([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=NC(F)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C2=C(N=C1C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])N(N=C2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl CCCC[C@@H](NC(=O)[C@H](C)N)B(O)O [H]OC1=C([H])C(O[H])=C2C(O[C@]([H])(C3=C([H])C4=C(O[C@@]([H])(C([H])([H])O[H])[C@@]([H])(O4)C4=C([H])C(OC([H])([H])[H])=C(O[H])C([H])=C4[H])C([H])=C3[H])[C@]([H])(O[H])C2=O)=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])C2=C1C([H])=NC1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C21)C1=C([H])C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[H])=C([H])N=C1[H] [H]C1=C(C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C(N=C=S)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] COC1=CC=C2C=C(C=CC2=C1Br)C1=CC(CO)=NN1C1=CC=C(C=C1)S(N)(=O)=O [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C3C(=C([H])N2N=C1SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C(=O)N([H])[H])C2([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C#N)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C([H])=C(C(C#N)=C1[H])C(F)(F)F)N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@]1(O[C@]2(C([H])([H])[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])C1=C(C#N)N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl [H]N(C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1O[C@]2([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C2N=C(N3N=C([H])C([H])=N3)N(C2=NC([H])=N1)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C([H])C([H])=C3[H])[S@](=O)C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N/C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[N+]1=C(C([H])=C(\C([H])=C(/[H])\C(\[H])=C2/N(C3=C(C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])\N([H])[H] [H]N(C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C2=C1C([H])([H])C(=O)N2[H] [H]N(C([H])=O)[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N(C1=NC([H])=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(C3=C([H])C([H])=C([H])C([H])=C3[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] CCCNC1=NC=C(S1)C1=CC(=NC(=N1)C1=CC=CC=N1)C1=C(OCC)C=CC=C1 [H]N(C(=O)C([H])([H])C1=C([H])N=C(N1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@]2([H])N(C(=O)[C@]3([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C4C3([H])[H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C1=C(Cl)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1\C(=O)N([H])C(=O)N(C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])N(C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(=N1)C([H])=C([H])C([H])=C2C([H])([H])N(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C(OC3=NC([H])=NC(=C3[H])C3=C([H])N=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2S1 [H]N(C1=NC([H])=C([H])S1)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C(C([H])=C2[H])C2=NC([H])([H])C3=C2C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=NC([H])=C3[H])N1C1([H])C([H])([H])OC1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1 [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(F)S2)C2=C([H])C([H])=C(F)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C(=O)N([H])C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)C([H])([H])N1C(=O)C([H])=C([H])N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C(=O)C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(C#N)C([H])=C2[H])C2=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1N([H])C(=O)C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NN(C([H])=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])SC(=N1)N([H])C(=N[H])N([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)OC([H])([H])C([H])([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=C(Cl)C(=NO2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@@]2([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[C@]([H])(C3=C([H])OC([H])=C3[H])C([H])([H])[C@]21C([H])([H])[H])C([H])([H])C([H])([H])C#N [H]N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])N=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1(C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H][C@@]12C[C@@H]3C[C@@H](C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)CN1N=C(CNS(=O)(=O)C(F)(F)F)N=C1CC1=CC=CC=C1 [H]N1C2=C(C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])C([H])([H])C2=C([H])C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(=N\C([H])([H])C([H])=C([H])[H])\N([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] CCN[C@H](CC1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])S(=O)(=O)C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=S)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C(N([H])S(=O)(=O)C([H])([H])[H])C(Cl)=C1[H])C([H])([H])[H] [H]C1=C(OC([H])([H])[H])N=C(C(=C1[H])C1=C2N=C(N=C(N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])F)N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] CNC(=O)C1=CC=CC(=C1)C1=C2CCN(C2=NC(=N1)N1CCOCC1)C1=CC=NC=C1 [H]C1=NC([H])=C(C([H])=C1[H])C1=NSC(=N1)C1=C([H])C([H])=C([H])C(Br)=C1[H] C1CN(CCO1)C1=CC=C(NC2=NC(=CN3C(=CN=C23)C2=CC=CN=C2)C2=CC=CN=C2)C=C1 [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])F)=C2[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC2=C1N=C([H])N=C2C1=C([H])C2=C(N1[H])C([H])([H])C([H])([H])N([H])C2=O [H]OC(=O)[C@]1(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C3=C([H])C([H])=C(O[H])C([H])=C3[H])C([H])([H])C(=O)N1[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])O[C@@]([H])(N2C([H])=C(C3=C2C([H])=C([H])C([H])=C3Cl)C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]1([H])O[H] [H]C1=C([H])N2C(S1)=NC(=C2C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=[N+](C([H])=C([H])N1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C(=NC2([H])[H])C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C2([H])[H])C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=N1 [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C(C([H])([H])N([H])C(=O)C1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(F)(F)F [H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])S1)C(=O)C([H])([H])F [H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC(Br)=C([H])C([H])=C1[H] [H]N1N=C(C2=NC3=C(N2[H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(\C([H])=C(/[H])C2=C([H])N=C([H])C(OC([H])([H])[H])=C2[H])=C1[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[N@@+]12C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[N@@+]12C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]ON([H])C(=O)C1(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]ON(C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])N=C(N([H])C2=NC(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C3C([H])=NC(SC([H])([H])[H])=NC3=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1C2=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=NC2=C1C([H])=NN2C([H])([H])[H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])SC1=NC(=O)N(C([H])=C1[H])[C@]1([H])O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H] [H]N([C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])[C@@](O[H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])N(C([H])([H])[C@]([H])(N=[N+]=[N-])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NN(C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N(C2=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(S[H])[C@]([H])([N+]([H])([H])[H])C([H])([H])C([H])([H])S([O-])(=O)=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O[H] [H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NN=C(O1)C1=C([H])C2=C(OC([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])\C(=N/[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(Cl)C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1N=C2C(=NC3=C([H])C([H])=C([H])C([H])=C23)N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])N(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S1 [H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])O[C@@]3([H])OC([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=NC([H])=C2S1 [H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C(=C([H])C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])=N2)C([H])([H])[H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=NC(N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C(Cl)=N1)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C(SC(=C1[H])[C@]1([H])OC2=C(N=NC(SC([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C([H])([H])OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC(F)(F)F)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])C1=C([H])N=C(OC([H])([H])[H])N=C1OC([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]1([H])O[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])C1=C([H])N=C(OC([H])([H])[H])N=C1OC([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H] [H]N1[C@]2([H])C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C([H])N=C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C([H])C2=C1C([H])([H])C([H])([H])N(C1=NC3=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N3C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(OC([H])([H])C4=C([H])C([H])=C([H])N=C4[H])=C3[H])C([H])([H])C([H])([H])N2N=C1C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N([H])C2([H])C([H])([H])C2([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C(Br)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N1C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C2=C1C1=C([H])C(=C([H])C([H])=C1C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(SC(=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])C(=O)N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(Cl)=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C(=O)C2=C([H])C([H])=C([H])C(Cl)=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C(=O)C1=NO[N+]([O-])=C1C(=O)C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C([H])([H])OC1=NC([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C(S1)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1Cl)C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])OC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=O)C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C(F)C(F)=C([H])C([H])=C4[H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])OC(=O)C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(N3C(=NN=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC(=O)C1=C([H])C(OC([H])([H])[H])=C2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]2([H])S[C@@]1([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C(N([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2N=C1[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H])[N+]([O-])=O [H]OC(=O)C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])S[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]C1=C([H])C(=C([H])C(Br)=C1[H])C1=C([H])C(=NC(=N1)C#N)C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C(Cl)C(Cl)=C1[H])C([H])([H])N1C2=NC(=C([H])C(=O)N2N=C1C1([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C4[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]N(C#N)C(=N\C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])\N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(OC([H])([H])[H])C(=N/C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H])\N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1(C#N)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])O[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N\C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\N([H])C#N)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]C1=C([H])C([H])=C(O1)C(=O)N(C([H])([H])C1=NN=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1C(=S)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[C@]2([H])SSC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])N(C2=C([H])SC3=C2C([H])=C([H])C([H])=C3[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C(N([H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=C1C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1N([H])C1=C([H])C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=NC([H])=C1C(F)(F)F [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=N1)C#C[C@](N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C2=NC(C3=NN=C(O3)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(N2C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])[H])C(Cl)=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C#C[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N2C(=O)C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)OC([H])([H])C([H])([H])OC(=O)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@]1([H])[C@]([H])(N(C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(O[C@]2([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(OC(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])[C@@]([H])(OC(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])[C@@]2([H])O[H])C(=O)C2=C(O1)C([H])=C(O[H])C([H])=C2O[H] [H]N1C(=O)N(C2=C1N=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=NN=C(O2)C2=C([H])C(Cl)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3\C2=C(/[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C(N=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H][C@]12NCC[C@@]1(C)C1=CC(OC(=O)NC3=C(C)C=CC=C3)=CC=C1N2 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC(=O)N([H])C([H])([H])[H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(C([H])([H])C([H])([H])N2C3=NC4=C(N3C([H])([H])C2([H])[H])C(=O)N(C(=O)N4C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C(C#N)C(=N2)C2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])SC1=C(C([H])=C([H])C(=C1[H])C1=NN(C2=C1C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[C@]([H])(O[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)N(C([H])([H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@]1(SC(=NC1=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)N([H])[H])C2([H])[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(O[H])C([H])=N2)C([H])([H])[C@]([H])(C([H])([H])[H])[C@]([H])(C2=C(F)C(F)=C([H])C(F)=C2[H])C1([H])[H] [H]OC1=C([H])C(F)=C([H])C([H])=C1C1=C([H])C(=C(C#N)C(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C([H])C([H])=C3N2[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])[C@@]1([H])C(=O)O[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=O)N(C2=C1C([H])=NN2C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N1C([H])=NC(=O)C2=C1C([H])=C(C([H])=C2[H])C1=C([H])N=C2N=C(OC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(=C(C([H])=N1)C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C(F)(F)F [H]N([C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C(OC([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(O[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1[C@@]2([H])C(C(=O)N(C([H])([H])C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C3([H])C([H])([H])C3([H])[H])=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(F)C([H])=C3Cl)C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H] [H]C#CC([H])([H])[C@]1([H])C2=C([H])C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C(=O)C([H])([H])C([H])([H])[C@]3([H])[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C(=O)C([H])([H])OC(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])O2)C(=O)N(C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1 [H]N(C1=C(Cl)C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C1=C2C([H])=C([H])C(C#CC3=NC(=C([H])C([H])=C3[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C2=NC([H])=C1C#N [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H] [H]OC([H])([H])C1=NN(C(=C1C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@](C2=C([H])C(O[H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1OC1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC1=NC2=C3N1C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC3(C(=O)N([H])C(=O)N([H])C3=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C(=O)OC1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])[H])[C@]1([H])[N@+]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(SC3=C2C([H])=C([H])C([H])=C3[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([S@@](=NC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[S@](=O)C([H])([H])[H] CC1=C(C=CC(O)=C1)C1=CC=C(O1)C1=C(C)C=C(O)C=C1 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(=N/C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])N(C2=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H])C1=NN=NN1[H] [H]N(C(=O)C([H])([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC2=C(C([H])=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F [H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(OC([H])([H])[H])=C2C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C([H])=C(Br)C(=C1[H])N1N=NC2=C1N=C(N=C2N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=NN([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]S[C@@]1([H])C(=O)C([H])=C2C([H])([H])C([H])([H])[C@]3([H])[C@@]4([H])C([H])([H])C([H])([H])C(=O)[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]OC(=O)C([H])(C(=O)O[H])C1=C([H])C([H])=C(C([H])=C1C(=O)OC([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C2=C1C(=C([H])S2)C1=C([H])C2=C(C([H])=C1[H])N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NN([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C2=C(N([H])C([H])=C2[H])C([H])=C1[H] [H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C(OC(F)(F)F)C([H])=C2[H] [H]N(C(=O)[C@]1([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=NN(C(=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]OC(=O)C1=C(OC2=NC(OC3=C([H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C(F)C(=C2F)C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C2([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C2C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C(Cl)=C([H])C([H])=C1F [H]\C(=C1/C(=O)N2C(=C([H])S[C@]12[H])C([O-])=O)C1=NN2C(=C1[H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(SC1=NC2=C(C3=C(S2)C([H])([H])C([H])([H])C3([H])[H])C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N(C1=C2C(=NN1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])N(C#C[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C(N([H])[H])=C2[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(N([H])C3=C(OC([H])([H])[H])C([H])=C([H])C(=C3[H])C(F)(F)F)C2=N1)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=NC(=C(S1)C([H])([H])[H])C1=C(N([H])C([H])=C1[H])C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C(Cl)C([H])=C([H])C2=NC(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N(C1=NC(=C(Cl)C([H])=N1)C1=C2C([H])=C([H])N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2N1C([H])([H])C1=C([H])C2=NSN=C2C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(C1=C(F)C([H])=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NC(=NC2=C1C(=C(N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N1C2=C(N=C1C([H])([H])C([H])([H])N1N=C(Cl)C([H])([H])C([H])([H])C1=O)C(=O)[C@@]([H])(C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=O)S\C(=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=O [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=C([H])OC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1=NC([H])=C(N1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@]1([H])[C@@]2([H])C([H])=C([H])[C@]([H])(C2([H])[H])[C@@]1([H])C(=O)N([H])C1=C(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])C2=C([H])N([H])C4=C2C(Br)=C([H])C([H])=C4[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]C1=C([H])C([H])=C2C(=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C2C([H])=C(N(C(=O)C3=C([H])C([H])=C(OC([H])([H])[C@]4([H])OC5=C(C([H])=C([H])C([H])=C5[H])C([H])([H])C4([H])[H])C([H])=C3[H])C2=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=NC([H])=C(F)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C2=C1C(=O)N([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=S)N([H])\C(=C(\[H])C2=C([H])C([H])=C(O2)C2=C([H])C(=C(C([H])=C2Br)C([H])([H])[H])C([H])([H])[H])C1=O [H]N(C1=C([H])N=C([H])N=C1[H])C1=C([H])C2=C(OC(=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@@]([H])(OC([H])([H])C2=C([H])C(OC([H])([H])[H])=C3C([H])=C([H])C([H])=C([H])C3=C2OC([H])([H])[H])C1([H])[H] [H]OC1=C2O[C@@]3([H])C(=O)C([H])([H])C([H])([H])[C@@]4(OC(=O)C5=C([H])C([H])=C([H])C([H])=C5[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C3=C([H])C([H])=C(N=N3)N3[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[H])C2=N1 [H]OC1=C(C([H])=C([H])C2=C1N=C([H])C([H])=C2[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C1=C2C([H])=C([H])C([H])=NC2=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C([H])([H])[C@@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C(=O)N1C2=C(C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C([H])[C@]2([H])C(=NC3=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]4([H])C([H])([H])[H])C([H])=C3C2=O)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C([H])C([H])=[N+]([O-])C([H])=C3N=C12)C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C2C(=NN1C([H])([H])[H])C1=C(SC(=C1C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]\C(=N/C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=C(C(=C1C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2N(C(Cl)=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2C(OC([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(F)C([H])=C2N3C(=NC(=C3N=NC2=C1OC([H])([H])[H])C([H])([H])[H])C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=NN1[H])C1=NC(=NC(=C1[H])N1C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H])N([H])[H] [H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C([H])N([H])N=C2[H])C(F)=C1[H] [H]C([H])=C([H])C([H])([H])SC1=NC2=C(N=N1)C1=C(C([H])=C([H])C([H])=C1[H])N(C(=O)C([H])([H])C([H])([H])[H])[C@@]([H])(O2)C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C1=NC([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C([H])C(OC([H])([H])[H])=C([H])C(Cl)=C2O[C@@]1([H])C(F)(F)F [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C1C(N([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N1C2=C(N=C1C1([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C(=O)C1=NOC2=C1C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])SN=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H] [H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(=C3[H])C3=C([H])C([H])=NN3[H])C2=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C1=C(C#N)C(=C([H])C(=N1)N([H])C1=NN([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])[H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C3=C(C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])[H] [H]OC1=C(C([H])=C(C([H])=C1Br)C([H])([H])[H])C1=C(C2=C([H])C(=C([H])C([H])=C2N1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NN(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])S1)C([H])([H])N(C(=O)C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])C1=NC([H])=C(C(=N1)C1=C(N=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C1C1=C(SC3=C1N=C([H])N(C3=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])N=C2[H] [H]OC(=O)C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])=NC3=C2N([H])C([H])=NC([H])([H])[C@@]3([H])O[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N\C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=NC(OC2=C([H])C(Br)=C([H])C([H])=C2[H])=C2N(C([H])([H])[H])C([H])([H])C3=C(OC2=N1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NSN=C23)C([H])=C(I)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C(Br)=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])[C@]1([H])O[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(=N\C([H])([H])C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C([H])=C3[H])[N+]([O-])=O)C([H])([H])C2([H])[H])\N([H])C#N)=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C(C(=O)N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C1=C([H])C(O[C@]2([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])C1=NC([H])=C([H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C(F)=C(C([H])=C2[H])C([H])([H])[H] [H]N1C(=NC2=C1C(=C([H])C([H])=C2[H])C(F)(F)F)[C@@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])OC3=C([H])C4=C(N([H])C([H])=C4C([H])([H])C([H])([H])N([H])[H])C([H])=C3[H])C([H])=C12 [H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N=C(N3[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]N(C(=O)N1C(=O)C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])[C@]1([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=NOC(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=N[C@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C(=O)N([H])C4=C([H])C([H])=C([H])C(F)=C4[H])[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])[H] COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(C=C1C)C(F)(F)F [H]C1=C(C(=O)[C@]23C([H])([H])[C@]4([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(C3([H])[H])C4([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=S)N([H])N([H])C(=O)C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NC(OC2([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NN(C2=NC(=O)N(C(=O)C2=N1)C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])N=C([H])S2)C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1N([C@]([H])(C([H])([H])[H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]OC([H])([H])C(\[H])=C(/[H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F [H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N([H])C(=N1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N2C(=N1)N=C(C([H])=C2N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H] [H]C1=C([H])C(=C2N=C(C(=NC2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=S)N(C(=O)C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2[H])C([H])=C1[H])C([H])=O [H]OC1=C2N([H])C(=O)C([H])=C([H])C2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C#N)[C@@]([H])(C2=C([H])SC([H])=C2[H])C2=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2=O [H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])C#N [H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=NN1[H])C([H])([H])[H])C1=NN(C(=O)C2=C1C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C#N [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C2([H])[H] [H]N(C(=O)[C@]([H])(SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C(=C1[H])C1=C([H])SC([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C(S3)C(=O)N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])([H])C([H])([H])OC2=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])N2C(Br)=C(N=C2C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(C2=C1C(=C([H])S2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H])C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(C#CC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=N1 [H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])C(F)(F)F [H]N1C([H])=C(C([H])=O)C2=C1C([H])=C([H])C1=C2C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]OC1=C(OC(=C([H])C1=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C([H])=C(O[C@]3([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]3([H])O[C@]3([H])OC([H])([H])[C@](O[H])(C([H])([H])O[H])[C@@]3([H])O[H])C([H])=C2O[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(OC1=O)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=C(C2=NC3=C(N2[H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(\C([H])=C(/[H])C2=C([H])N=C([H])C(C#N)=C2[H])=C1[H] [H]C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]N1C2=C(C([H])=C([H])C(C#N)=C2[H])C2=C1C(C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C2=O)(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]OC1=C(C([H])=C([H])C([H])=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])SC([H])=C1[H])C1=C([H])C2=C([H])N=C([H])C([H])=C2N1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C1=C([H])N(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C2([H])[H] CN1C(N)=N[C@](C1=O)(C1=CC=C(OC(F)F)C=C1)C1=CC(C#CCCCF)=C(F)C=C1 [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)OC([H])([H])C([H])([H])[H])=C1[H] [H]C1=NC(Cl)=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N=C(O1)C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])C(\[H])=C(/[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(SC([H])([H])C(=O)N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])=C1C([H])([H])[H] CN(C(=O)C1=CC=C(S1)C1=CC(O)=CC=C1)C1=CC=CC(C)=C1 [H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(C2=C3N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C4([H])C([H])([H])C4([H])[H])C3=NN2C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC(C)(C)OC(=O)CCCC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1 [H]N(\N=C(/[H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])S2)C([H])=C1[H])C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(N2C([H])([H])C(=O)N([H])S2(=O)=O)C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C2=NOC(=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(O[H])=C1[H] [H]N([H])N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]OC1=C(SC(=N1)C1=C([H])C([H])=C(SC(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H])C(=O)N([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(C3=C([H])C([H])=C(O[H])C([H])=C3O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O2 [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C(=C(N([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C1Cl)S(=O)(=O)N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])OC1=C([H])C([H])=C(Br)C([H])=C1C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N(C1=C([H])C(OC([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=NC([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C#CC([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C12)N1N=C([H])C([H])=N1 [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(SC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H] [H]N1C(C#N)=C([H])C2=C1C(=C([H])N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]OC1=NSC(N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C#N [H]C([H])=C([H])C([H])([H])[C@@]1([H])\C([H])=C(C([H])([H])[H])\C([H])([H])C([H])([H])OC(=O)OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C(=O)OC(=O)C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C(=O)N([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC2([H])[H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC2([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C(N([H])C2=NC([H])=C1Br)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1N=NC(=C1[H])C1=C([H])C([H])=C([H])C(O[H])=C1[H] [H]N([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@@]1([H])N(N=C(C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] CCOCCN1C(NC(=O)C2=CC=CC(=C2)C#N)=NC2=CC(=CN=C12)C(=O)N1CCOCC1 [H]O[C@]1([H])[C@]([H])(OC([H])([H])[H])O[C@@]([H])(C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]1([H])O[H] [H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=C([H])N=C([H])C([H])=N4)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(O[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C(=O)O[H] [H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])N(C3=C([H])C([H])=C([H])N=C23)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])[H] [H]N1C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])\C(=N\OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@@]3([H])C([H])([H])N(C([H])([H])[C@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C(Cl)=C1[H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)\C2=C(\[H])C2=C([H])C([H])=C([H])N2[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C([H])N=C4N([H])C([H])=C([H])C4=C23)C([H])([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])N1C(=O)C2=C(C1=O)C1=C(N(C3=C1C([H])=C([H])C([H])=C3O[H])[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H])C1=C2C2=C(N1[H])C(O[H])=C([H])C([H])=C2[H] F[P-](F)(F)(F)(F)F.CN(C)C1=CC=C2C([Te]C3=CC(C=CC3=C2C2=CC=C(S2)C(=S)N2CCCCC2)=[N+](C)C)=C1 [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]12[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C(=O)N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])[C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])S(=O)(=O)C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C2=C([H])C([H])=NC([H])=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])N(C(=O)C4=C(N=C(N=C4C([H])([H])[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[C@]3([H])C2([H])[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)S1 [H]C1=NOC(=N1)[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])\C(=N/OC([H])([H])[H])C1([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(S1)C1=NN(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])N=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C#CC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=C([H])[H])C(=O)N([H])[H])C1=C([H])OC([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])N([H])C1=C([H])C([H])=C(C([H])=C1Cl)S(=O)(=O)N([H])[H] [H]N([C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] NC1=CC(=CC=C1)C1=CC=C(CCC(=O)N2CCC[C@H]2C2=NC=C(N2)C2=CC=CC=C2)C=C1 [H]N(C1=NC([H])=C([H])C(=N1)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C(S1)C(=O)OC([H])([H])C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F [H]OC(=O)[C@]([H])(OC1=C(C2=C(C([H])=C1Cl)C(=NO2)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])S(=O)(=O)N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(SC2=NN3C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(Br)C([H])=C2Cl)=C2C([H])=C(N([H])C2=N1)C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]C1=NN=NN1C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C(=NC(SC([H])([H])C([H])([H])C(=O)N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])=N1)C(F)(F)F [H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C(C([H])=C([H])C([H])=C3[H])C(=O)O[H])=C(N([H])[H])C([H])=N2)C([H])=C1[H] [H]N(C(=O)C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C2[H])=C1\C(=N\[C@]([H])(C([H])([H])[H])C([H])([H])O[H])N([H])[H] [H]N([H])C1(C(=O)N([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[C@@]([H])(N([H])[C@]3([H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1=O)[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])SC([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N [H]N([H])C(=O)C1=C2C(=O)N(C([H])([H])C2=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]ON(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])OC([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(O[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=O)O[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N1C([H])=NC2=C([H])C(=C([H])C([H])=C2C1=O)C(F)(F)F [H]N(C1=NC([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC(=O)[C@]1([H])N2C(=O)[C@]([H])(N([H])C(=O)C([H])([H])S[H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@@]2([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C1C1=C([H])C([H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N([H])C([H])=N2 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H] [H]OC(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])N1N=C(C([H])([H])[H])C([H])([H])C1=O CNC1=NC(C)=C(S1)C1=NC(NC2=CC(=CC=C2)N2CCCNCC2)=NC=C1C#N [H]C1=C(N(N=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C2N=C(C([H])=C(N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(=NN=C2C2=C([H])C([H])=C3C([H])=C([H])C([H])=C(OC([H])([H])C4(F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C3=N2)C([H])=C1[H] [H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C#C[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C1=NC([H])=C2N=C(SC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] COC1=CC2=C(C=CN=C2C=C1)C1CN(C2CCN(CC3=NC4=CC=CC=C4C=C3)CC2)C(=O)O1 [H]C1=C(C(=O)C2=C3C([H])=C([H])C(OC([H])([H])[H])=C([H])C3=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]OC1=C([H])C(=NC2=NC(SC([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])=NN12)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])[N+]([O-])=O)C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(O[H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1([H])C2=C(O[C@@]3(C([H])([H])[C@]([H])(F)C3([H])[H])C1([H])[H])N=C([H])C(=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C4C(=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C4([H])[H])=C([H])C([H])=C1C2([H])[H] [H]N1N=NC2=C3C(=C([H])C([H])=C12)C1=C(Br)C(=O)C([H])([H])C([H])([H])[C@@]1(C([H])([H])C([H])([H])[H])C3([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]\C(=C(\[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=N1 [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C#N)C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(C(=S)N([H])[C@@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C1=C(Cl)C([H])=C([H])C2=NC(=C(C([H])=C12)C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])\C(=C(/C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(=C1C#N)C1=C([H])C([H])=NC([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=NN1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])SC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NN([H])C2=C1C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N1N=NN=C1C(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)=C2C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)OC([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])C(=O)C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@]([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N2OC(=O)C(=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C(Cl)C(F)=C([H])C([H])=C2F)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C1N([H])C([H])=NC1=C2[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])SC1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=O)N([H])[H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])[C@]12[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C3=C(N=C2C([H])=C1N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C3[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C2SC(=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] CN1C(=N)N[C@]2(CN(C[C@H]2C1=O)C1=NC(C)=C(F)C(C)=N1)C1=CC=CC=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H] [H]N([H])C(=O)C1=C([H])N(C2=C(C([H])=NC(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C1C([H])([H])[C@@]([H])(N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NC(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=NC2=C(O1)C([H])=C([H])C(Br)=C2[H] [H]N(C(=O)C1=C(N=C([H])S1)C([H])([H])C([H])([H])C1=C([H])ON=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C(C3=C([H])OC([H])=C3[H])C3=C(N=C([H])N=C23)N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C#CC([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]ON1C([H])=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]2([H])O[H])[C@]1([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=NC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C1=NN=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]2(ON=C(C3=C([H])C(N([H])C(=O)C(=C([H])[H])C([H])([H])[H])=C([H])C([H])=C3[H])C2([H])[H])C1([H])[H] [H]N(C(=O)OC([H])([H])[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])N=C1[H] [H]ON([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])S(=O)(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C(F)C([H])=N2)C([H])([H])C1([H])[H] [H]OC1=C(C(=C(C2=C1C(=O)OC2([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])P(=O)(O[H])O[H] [H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C([H])C([H])=C(F)C(C#N)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=C(C([H])=NC(=N1)N([H])[C@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(OC(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]2([H])O[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C1(C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C([H])C([H])=C1F [H]OC1=NC(=NC2=C1N([H])C([H])=C2C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])N([H])[H] [H]N([C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C2=NN([H])C([H])=C2C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C(=NC(Cl)=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=NN2C([H])=C(C([H])=NC2=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(SC([H])([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])N(N=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])[H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] CC(C)[C@@H](CO)NC1=NC(NC2=CN=CN=C2)=C2N=CN(C(C)C)C2=N1 [H]N(\C(=N/C#N)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC1=CC=C(OC2=CC=CC=C2)C=C1)B1O[C@@H]2C[C@@H]3C[C@@H](C3(C)C)[C@]2(C)O1 [H]ON([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2[C@](C1=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=NN(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C(=O)C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N1C(=O)C2=C([H])C(OC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N([H])C(=O)C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C2N([H])C(=O)SC2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)C(=C(/[H])C1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])[N+]([O-])=O)\C1=C(F)C([H])=C([H])C([H])=C1[H] [H]OC1=C(Br)C([H])=C([H])C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])N([H])C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])S1(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC2=C1N=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[C@@]2([H])N([H])C(=O)C(N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])C3=C(N(N(C3=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(F)=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])=C1C(=O)N([H])[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] C1CC(CCO1)NC1=CC(=CC=N1)N1C2=C(C=CC=C2)N=C1C1=CC2=CC=CC=C2C=C1 [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])[C@@]2([H])C(=O)N(C([H])([H])C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])[C@@]([H])([C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@](N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C2([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]ON(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C#CC1=NN(C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] COC1=CC(=CC=C1OCCN1CCCC1)N1CC2=CC=C(N=C2C1=O)C1=CC=C(C=C)C=C1 [H]OP(=O)(O[H])C(F)(F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C1=NC(SC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(N1C([H])([H])[H])C(=O)N([H])[H])C([H])([H])[H] [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@@]([H])(C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(=C(OC([H])([H])F)C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=NC2=C1C([H])=C([H])C(=C2[H])N1C(=C([H])C2=C1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(S1)[N+]([O-])=O)C([H])([H])C1=C([H])C2=C(OC(=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C(O[H])C(=C([H])C(Br)=C1[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1([H])C([H])([H])C1([H])[H] COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)N3C(=O)NN=C3C)C2=O)C=C1 [H]N1N=C(N=C1C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])N1C(=O)[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]2([H])C1=O [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])[C@@]2([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(Br)SC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N([H])[C@@]1(C([H])([H])[H])C([H])([H])N(C2=C([H])C3=C(N2C([H])([H])C2=C(C#N)C([H])=C([H])C([H])=C2[H])C(=O)N(C([H])=N3)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C(OC([H])([H])[H])=C([H])C2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O\N=C(\C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)[C@@](C(=O)C2=C(Br)C([H])=C(Br)C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])C2=C(C(=NC([H])=N2)N2C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]