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[H]C([H])=C([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NC(=N1)[C@@]([H])(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]OC1=C([H])C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C3=C(OC([H])=C3[H])C(OC([H])([H])[H])=C2O[H])=C([H])C([H])=C1[H]
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[H]N([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(Cl)C([H])=C(C([H])=C1Cl)C([H])([H])[H]
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[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H]
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[H]N(C1=NN2C([H])=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C(Cl)=C3[H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)C([H])([H])F)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)S1
[H]N(C(=O)N([H])C([H])([H])C1(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C(=N1)C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C(C([H])=C1C1=C([H])C(=NC(=N1)C#N)C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])([H])[H]
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[H]C1=NC([H])=C2N1C([H])([H])C1=C([H])C(OC3=C([H])C4=C(C([H])=C3[H])C([H])([H])C([H])([H])[C@@]4([H])N3C(=O)[C@]([H])(N(C([H])([H])[H])C2([H])[H])C([H])([H])C3([H])[H])=C(C#N)C([H])=C1[H]
[H]N(C1=C([H])C2=C(N([H])C(=O)C([H])=C2C(F)(F)F)C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C(I)C([H])=C(C([H])=C1I)C([H])([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
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[H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
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[H]C1=C([H])C(C#N)=C(C([H])=C1N1C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])F)C(C1=O)(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
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[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]\C(C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(Cl)S1)=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
[H]N1C(=NC2=C1N(C(=O)[C@]([H])(C2=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=O
[H]N(C1=C([H])C(=NC([H])=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H]
[H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1OC([H])([H])[H])[N+]([O-])=O
[H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N1C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=NN(\C(S1)=N\C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC(=NN1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
NS(=O)(=O)C1=CC=C(NC(=O)C(=N\NC2=CC=CC=C2)\C#N)C=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N([C@]([H])(C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C3=NN=C(C([H])=C3C(=O)C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]C([H])=C([H])C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H][C@@]12CC(=O)CC[C@@]1([H])C(C)(C)OC1=C2C(O)=CC(CCCCC)=C1
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[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C(N([H])C5=C4C([H])=C([H])C([H])=C5[H])[C@]3([H])C([H])([H])[C@]2([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C(N([H])C5=C4C([H])=C([H])C([H])=C5[H])[C@]3([H])C([H])([H])[C@]12[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
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[H]N(C1=NC(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C2N=C([H])N([H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC(OC([H])([H])[H])=C3C(=N2)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NN2C([H])=C([H])C([H])=NC2=C1C1=NC([H])=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N([C@@]([H])(C1=NN(C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2C([H])([H])C([H])([H])S(=O)(=O)[C@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=NC4=C([H])C([H])=C([H])C([H])=C4S3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])[C@@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C(N([H])C([H])([H])C2=NC(=C(N2[H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C3N=C([H])C([H])=NC3=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])N1N=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])N1C(=O)N2C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])C1=O
[H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])S1)C([H])([H])N(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(C1=C([H])C([H])=C([H])N1C([H])([H])[H])=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)C(OC1=C([H])C(Cl)=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
CC1=CN=C(CNCC2(O)CC3CCC(C2)N3C(=O)C2=CSC=C2)C=C1
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(=NC2=C(C([H])=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C([H])C(Br)=C4[H])C([H])([H])C(=O)N([H])C2=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C1=NN([H])C(=O)N1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H]
[H]N([H])C1=NN([H])C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2F)C(F)(F)F)C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])[H]
NC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(S1)C(O)(C(F)(F)F)C(F)(F)F
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(O2)C(=O)C2=C(O1)C([H])=C(O[H])C([H])=C2[H]
[H]C1=C(OC([H])([H])[H])N=C2N3C(=NC(=C3C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
OC1=CC=C(C=C1)[B]1234[B]567[B]89%10[B]%11%12%13[B]585[B]%118%11[B]%12%12%14[B]9%139[B]16%10[C]2%129[B]38%14[C]475%11
[H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(Cl)C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N3C(=O)C4=C(C([H])=C([H])C(OC([H])([H])[H])=C4OC([H])([H])[H])[C@]3([H])SC2=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])N([H])C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C(=O)N(C1=O)C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H]
COC1=C(OC2=CC(O)=CC(O)=C2C1=O)C1=CC=CC=C1
[H]C1=NC(=C([H])N1C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C([H])C(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C(C([H])=C12)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]S\C(=N\C([H])([H])C1=C([H])N=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])O[P@](=O)(O[H])OC([H])([H])[C@@]2([H])O[C@@]([H])(N3C([H])=C([H])\C(=N\OC([H])([H])[H])N([H])C3=O)[C@]([H])(O[H])[C@]2([H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C(=O)N([H])C1=O
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N2C3=C1C([H])=C(F)C([H])=C3C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])C2([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C(=[N+]([O-])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=NN=C(S1)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])(P([O-])([O-])=O)P([O-])([O-])=O
[H]N([H])C([H])([H])C1=C([H])C([H])=C(C#CC([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C(=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(Cl)C2=C(S1)C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N=C(S1)C1=C([H])C2=C(C([H])=C1[H])C(=C([H])N2C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C2N(C([H])=C1[H])[C@]([H])(SC2([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
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[H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(Br)C(Br)=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C([H])C([H])=C(C([H])=C2O1)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=NC5=C(S4)C([H])=C([H])C([H])=C5[H])C([H])=C3[H])C2=C1[H]
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[H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C([H])=O)C2=C([H])C([H])=C([H])C([H])=C12
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[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])N=C(N=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
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[H]N1C([H])([H])C([H])([H])N(C2=C3OC([H])=C([H])OC3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C(N2N=C(N(C(=O)C2=C1C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
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[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])\N=C2/C(=O)N([H])C3=C([H])C([H])=C([H])C(OC4=C([H])C([H])=C([H])C([H])=C4[H])=C23)C([H])=C1[H]
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[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
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[H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(\C([H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(C([H])=C12)C1=C([H])OC([H])=C1[H])C1=C([H])N=C(C([H])=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C2=C([H])C(C#N)=C(SC([H])([H])[H])C([H])=C2[H])[C@](C1=O)(C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(\C([H])=C(\[H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
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[H]N1C(=NC2=C([H])C(Cl)=C([H])C([H])=C12)C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N([H])C(=O)C1=C2C(=O)N(C([H])([H])C2=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2OC([H])([H])C([H])([H])O3)C([H])([H])C1([H])[H]
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[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C#N)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])=C1[H]
[H]O[C@]1(\C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])=C1\C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC(=O)C1=C([H])C([H])=C(O1)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])N([H])[H]
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OC(=O)C1=CC2=C(OC(=C2\C=C/C2=CC=C(OC(F)(F)F)C=C2)C2=CC=CC=C2)C=C1O
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[H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
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[H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
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[H]N1C([H])=C([H])C2=C1N=C([H])N=C2N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C(=O)O[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])[C@]2([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N1C(=NC([H])([H])C1([H])[H])C([H])([H])N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O
[H]C1=C([H])C(OC(=O)C([H])([H])[H])=C(SC([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N1C2=C(C([H])=C(Cl)C([H])=C2[H])[C@@]2(N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2N([H])C2=C([H])C([H])=C([H])C([H])=C32)C1=O
[H]OC(=O)C1=C([H])OC(=N1)N1C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@]2(N(C(=O)N(C2=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C1([H])[H]
FC(F)(F)C1=CC=C(SCC(C2=CNC=N2)C2=CC=NC=C2)C=C1
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C([H])([H])C1=C(N2N=C(N=C2N=C1C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(N=C(N=C3N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])N3C(=NC4=C3C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C([H])([H])[H])N2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C([H])=NN(C2=NC([H])=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C(C([H])=N2)C2=NC([H])=C([H])S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C(C(=O)C2=C([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])S([O-])(=O)=O)C3=C2C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C2N1[C@]([H])(SC2([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C(Cl)=C([H])C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])S1
[H]OC(=O)C([H])([H])N1C(SC([H])([H])C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=NC2=C([H])C(F)=C([H])C([H])=C12
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])[C@@]2([H])C3=C(SC([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=NC2=C([H])C([H])=C(C([H])=C2N=C1[H])C1=C(C(=O)N(N1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C(=O)C2=C(C([H])=C(N2N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON(C(=O)N([H])[H])[C@]([H])(C1=C([H])C([H])=C(O1)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N2N=C(C([H])=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=C([H])C(=C1C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])N=C2C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(F)C([H])=C([H])C(F)=C3[H])N(C3=C([H])C([H])=C([H])N=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N([H])C2(C3=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1=C(C([H])=C([H])C(OC([H])([H])[H])=N1)[N+]([O-])=O
O\N=C1/C2CCN(CC2)/C/1=C\C1=CN(CC2=CC=C(Cl)C=C2)C2=CC=CC=C12
[H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C(C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C([H])C(C(=O)N3C([H])([H])[C@]([H])(N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@]3([H])C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
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[H]OC(=O)C1=C([H])N(C2=C(F)C(N([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])=C(F)C(N([H])[H])=C2C1=O)C1([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])=C([H])C2=C1N=C(N=C2[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C([H])N=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N1C([H])=C([H])C2=C1C1=C(C([H])=C2[H])C2=C(C3=C(N2[H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C3[H])C2=C1C(=O)N([H])C2=O
[H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(OC(=O)N(C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C2N(C3=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]OC1=C(SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C(Cl)C([H])=C(OC(=O)C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(C([H])=C1C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C#N)C2=C(C(SC([H])([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=N1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])P(=O)(O[H])O[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C1=NC([H])=C([H])C([H])=N1)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=C2N=C(C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1=O)N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H]
C(N1CCN(CC1)C1=CC2=CC=C1CCC1=CC=C(CC2)C=C1)C1=CN(N=C1)C1=CC=CC=C1
[H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C3=C2C2=C([H])N(N=C2C([H])([H])C3([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(C2=C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C3(C([H])([H])C3([H])[H])C2([H])[H])=C(F)C([H])=C1F
[H]N(C1=NC([H])=NN2C([H])=C(OC([H])([H])[H])C(=C12)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=NC(O[H])=C(N=C1C([H])([H])[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(S2)N([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(C1=NN=C(O1)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C(Br)=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C(=C(C([H])=N1)C1=NC(=C2N=NC3=C(OC([H])([H])[H])C([H])=C(F)C([H])=C3N12)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@]2([H])C1=NC([H])=C([H])N1[H])S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=NC([H])=C(S1)C([H])([H])C1=C([H])C(=C([H])C([H])=C1Cl)C(F)(F)F
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NC(=O)ON1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
O=C(NCC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1)C1CCC1
[H]N1[C@]2(C([H])([H])N(C([H])([H])C(F)(F)F)S1(=O)=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C2=C(C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C3([H])[H])C(F)(F)F)=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N(C(=C(Br)C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C#N)C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C#CC1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=NN=C(N2C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C(SSC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC(=O)C([H])([H])OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C(N([H])C2=NC([H])=C1Br)C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H]
[H]N(C1=C([H])C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(N([H])C([H])([H])C([H])([H])[H])=C2C(=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])O[H])C2([H])[H])C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])[C@@]([H])(C([H])=C2C3=C([H])C([H])=C([H])C4=C3C(=C([H])N4[H])C([H])([H])[C@@]12[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])C1=C([H])C(I)=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=NC(=C(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N(C1=C(C#N)C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
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[H]ON([H])C(=O)C([H])([H])N(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
ClC1=CC2=C(C=C1)N=C(CCNCC1=CC=C(C=C1)C1=NN=C3N1C1=CC=CN=C1NC1=C3C=CC=C1)N2
[H]OC1=C(N([H])C2=N[S@@](=O)N=C2N([H])[C@@]([H])(C2=C([H])C(=C([H])O2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])OP([O-])([O-])=O)[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
NC1=NC=CC(=N1)C1=CC(C#N)=C(OCC2CCCCC2)C=C1
[H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C([H])=[N+]1C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N(\C(SC([H])([H])C1=C([H])SC2=NC3=C(C([H])=C([H])C([H])=C3[H])N12)=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN=C(O1)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4([H])[C@]([H])(N(C([H])([H])C(\[H])=C(/[H])C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]C1=C([H])C([H])=C(C(=O)C([H])([H])[H])C(OC([H])([H])C([H])([H])N2N=NC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])=C([H])C([H])=C2C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C(Cl)(Cl)Cl
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[P@@](=O)(C([H])([H])[C@]([H])(C(=O)N(N([H])[H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C2C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2N=C(OC([H])([H])[H])N3C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
NS(=O)(=O)C1=C(F)C(F)=C(SCC(O)=O)C(F)=C1F
[H]N1C(=C([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
CS(=O)(=O)C1=CC(NC2=NC(=CC=N2)N(CCO)C2=C3OCOC3=CC=C2Cl)=CC=C1
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])SC([H])([H])C1([H])[H]
Cc1cnc(N)nc1-c1c[nH]c(c1)C(=O)N[C@H](CCO)c1ccccc1
[H]N(C1=C(Cl)C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C1=C2C([H])=C(OC([H])([H])[H])C(C#CC3=C([H])N=C([H])C(=C3[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C2=NC([H])=C1C#N
[H]C1=C(C([H])=C2C([H])=C([H])C(=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=O)C([H])([H])Cl)N([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(S1)SC(=C2[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C1=C2C3=C(C#N)C([H])([H])C([H])([H])C(=O)N3C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C(N([H])[C@@]([H])(C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])[N+]([O-])=O
[H]N([H])C1=NC(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C#N)C(=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])C(=O)OC([H])([H])C(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
[H]N=C(SC([H])([H])C([H])([H])[H])N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]\C(OC([H])([H])C([H])([H])[H])=C1/C(=O)N(C(=O)C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C(O[H])=C1[H])C(=O)C1=C(O2)C2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]N(\N=C(/[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C1[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(C([H])=C(N4N=C([H])C([H])=C4[H])C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(SC2=NC(=C([H])C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C(F)=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1N([C@]([H])(C([H])([H])[H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C(=O)C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C3=C(N=C2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C2C([H])=NN(C2=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=NC(N([H])C3=NN([H])C(=C3[H])C([H])([H])[H])=C([H])C(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
CN1CCC(CC1)C1=CN(C2=CC=C(C=C12)C1=CN=CN=C1)C1=CC=C(F)C=C1
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)S1)[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC#CCN1C(=O)C2=C(N=C1N1CCC[C@@H](N)C1)C(Br)=CN2
[H]C1=C([H])C(C(=O)C2=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C23)=C2N1[C@@]([H])(SC2([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N1C(=NC2=C3N([H])C(=NC3=C3N([H])C(=NC3=C12)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C([H])C(=N1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H]
CC1=CC(C[C@@H]2CNC[C@@H]2OCCNC2CC2C2=CC=CC(Cl)=C2)=NC(N)=C1
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C2N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])N([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])C2([H])[H])=C2C(SC3=C2N=C([H])N(C3=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])=N1
[H]\C(=C(\[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2N=C1Cl)C([H])([H])[H])C(=O)C1=C(Cl)C([H])=C([H])S1
[H]N([H])[C@]([H])(C1=NN=C(O1)SC([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1N=C2C3=C(OC4=C2C(=C([H])C([H])=C4[H])C1=O)C([H])=C([H])C(=C3[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/C([H])([H])[H])[C@@]2([H])OC(=O)[C@@]3([H])N(C(=O)C(=O)[C@]4(O[H])O[C@@]([H])([C@@]([H])(OC([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])[H])[C@@]([H])(OC([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])\C(=C([H])\[C@]([H])(C(=O)C([H])([H])[C@]([H])(O[H])[C@@]2([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]C1=C(SC2=NC(=C(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N12)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])[H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C(=O)C1=C([H])C(Cl)=C([H])N1[H]
[H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])OC(O[C@]1([H])C1=C([H])N=C([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])N1C(=O)S\C(=C(\[H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O
[H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
COC1=CC(=CC=C1OCCCNC(=O)NC1=CC=C(C=C1)C(F)(F)F)C1=C(NC2CCCCC2)N2C=C(Cl)C=CC2=N1
[H]N(C(=O)C([H])([H])N1C(=O)[C@]([H])(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1F)C([H])([H])[H])C1=C(F)C(F)=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C2([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C(F)C([H])=C(F)C([H])=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])[C@@]1([H])N([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C(Cl)C([H])=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(Cl)=C2[H])[C@@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(OC([H])([H])[H])C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C([H])=C23)C(=O)OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C(C([H])=C(N(C2=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(O[H])=N1
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[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C(\[H])=C(/[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1N1N=C(C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(C2=NN=C3SC(=NN23)C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
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[H]N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(N([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])[H]
[H]C1=C(SC2=C1C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C21)C(=O)N(C1=C([H])C([H])=NC([H])=C1Cl)C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C21C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(F)C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])[N+](=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])[H])C([H])([H])C(F)(F)F)C(F)(F)F
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C[C@H](OC1=C(Cl)C(Cl)=CC=C1)C(=O)NC1=CC=CC(NC(=O)C2=CC=NC=C2)=C1
[H]C1=C([H])C(=C2N=C(C([H])=NC2=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
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[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=[N+]1C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
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[H]\C(=C(/C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]N(C1=NC(=C([H])C(=O)N1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)C(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
OC(=O)CCCCCC1=CC2=C(NC(=C2)C2=CC=C(C3=CC=CC=C3)C(=C2)C(F)(F)F)C=C1
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[H]ON([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)OC([H])([H])C1(C([H])([H])OP([O-])(=O)OC([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C(C2=C(N=C([H])N=C12)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([C@@]1([H])C([H])([H])N(C#N)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C(F)C(=C2[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
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O=C(CCNC(=O)C1=CC=C(C=C1)C#N)N1CCC[C@H]1C#N
CCCCCN1C=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C(=O)C2=C1N(C)N=C2
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C[C@@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(=O)N1CC(C1)C#N
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ClC1=C(CCNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NC3CCCC3)=N2)C=CC=C1
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[H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C(F)(F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H][C@]12CCNC[C@@]1([H])C1=CC(=CC3=C1N2CCC3)C1=C(C=C(OC)C=C1)C(F)(F)F
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[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
COC1=CC=C2C(=C1)N(C(OC1=CC(F)=CC=C1C)=C2C(=O)N1CCNCC1)C1=CC=CC=C1
[H]N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]O[C@@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@](O[H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
CC1(C)CCC2=C(N=C3SC4=C(N=CN=C4NCCN4CCOCC4)C3=C2C1)N1CCCC1
[H]OC([H])([H])[C@]1(OC(=O)\C(=C(\[H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C#C[H]
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[H]N([H])C(=O)C1=C([H])C([H])=C([H])N=C1OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=NC([H])=NC(=C1[H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C2N([H])N=C([H])C2=C1[H])C([H])([H])[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
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FC1=CC=C(C=C1)[Si]1(CCC(C1)N1CCN(CC1)C1=CC=CC=C1)C1=CC=CC=C1
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[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1=NOC([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@]3([H])N(C(=O)C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N(C1=C(SC([H])([H])C([H])([H])[H])C(=O)N(N=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])=C([H])N([H])C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
CC1=C(C=CC=C1Cl)C(=O)N1CCC[C@@H](C1)C1=NC(=NO1)C1=CC=CC=C1
[H]N1N=C(OC1=S)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])SC1=NN=C3N1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C31)C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C(N([H])C2=C([H])C(F)=C(OC3=C4C([H])=C([H])N([H])C4=NC([H])=C3[H])C([H])=C2[H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F
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CC1=C(OC2=CC=C(C=C2)N2C=NN=N2)N=CN=C1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
[H]N([H])C1=NC(N([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])=C2C([H])=C(N([H])C2=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C2=C([H])C([H])=C1\C(=C1/N=C(C([H])=C1[H])/C(=C1\N([H])\C(\C([H])=C1[H])=C(/C1=N/C(/C([H])=C1[H])=C2/C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H])/C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C2=C(Cl)C([H])=C(N=C2C([H])=C1[H])C([H])([H])O[H])C([H])([H])C([H])([H])[H])C(=O)O[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Br)C([H])=C([H])C([H])=C1[H]
COC(=O)NCCC1=CC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)=C1
[H]N1C(=NC2=C1C([H])=C(F)C(=C2[H])C(F)(F)F)C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])N=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN(C([H])=N1)C1=C([H])C(=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]ON([H])C(=O)C1=C([H])C([H])=C([H])C(=C1N(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N(C2=O)C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C1=C2C(=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(\N=C(\C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])S[C@]1([H])O[C@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]1([H])OC(=O)C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N([H])[C@@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C(Cl)C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C(OC2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N=C1C([H])([H])[H])[N+]([O-])=O
[H]OC([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2C(N=C(N=C2C2=C([H])C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])O[H])=C1[H]
[H]O[C@@]1([H])[C@]([H])(OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])O[C@]([H])(C([H])([H])OC(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N1C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
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[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])N(C3=C2C(Br)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(OS(=O)(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2OC([H])([H])[H])=C1[H]
[H]OC1(C([H])([H])N([H])C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(S2)C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1Cl
[H]C1=C([H])C(C2=C3N=C(C([H])=C(N3N=C2C([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])S1
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C#N)C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])N(C1=C([H])C([H])=C(C#N)C(Cl)=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N([H])C1=C([H])C([H])=C(Br)C([H])=C1C(=O)N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N([H])C(=O)C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C(C([H])=C([H])C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C(=C1[H])[N+]([O-])=O)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
CC1=CC(CC2=CC(C(=O)N3CCC4=C5C3CNC(=O)C5=CC=C4)=C(F)C=C2)=NNC1=O
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C(F)C([H])=N1)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N([H])C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])N(C3=C([H])N=C(Cl)C(=C3[H])C([H])([H])[H])C([H])([H])[C@]12[H]
[H]N(C1=C(C(=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C(=NN3[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C2=C1N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C3=C(N=C([H])C([H])=C3N2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C2OC([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(SC(=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=NN1C1=C2C(=NC(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
[H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C(=O)N(C2=C(C1=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N1N=C(C([H])=C1[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C4=C([H])C([H])=C(Br)C([H])=C4[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C(C#N)C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NNC2=C1C=CC=C2C(C)(C)O
[H]C([H])=C([H])C([H])([H])N([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C#CC([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=C([H])C2=C([H])C([H])=NC([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C(N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2S1
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]N(C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])=C(C2=C([H])C([H])=C(S2)C#N)C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2N=C1[H])S(=O)(=O)C([H])([H])[H]
C(COC1=NC2=C(CCN(CC3=CC=CC=C3)C2)S1)CN1CCCCC1
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])N(N=C2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl
[H]C1=C([H])C(=C([H])C([H])=C1Br)C1=NN(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])C1=C(C(Cl)=C([H])S1)C1=NC([H])=NN1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=NOC(=N1)[C@@]12C([H])([H])C([H])([H])[C@@](C3=NN=C(N3C([H])([H])[H])C3=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C3[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])N1C(=N[H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(O[H])C2=C1OC1=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C(=O)[C@@]21C([H])([H])[H]
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C(C#N)C([H])=C([H])C(=C1[H])[C@@]([H])(OC([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])N=C([H])N1C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[C@]1([H])C([H])([H])[H])C(=O)OC([H])([H])[H]
[H]N(C(=O)C1(C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[P@@]1(=O)OC([H])([H])[C@]([H])(N([H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])O1)C([H])([H])C(F)(F)F
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C([H])([H])OC([H])([H])C([H])([H])[H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C12C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3C([H])=C([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)C1=C(Cl)C([H])=C(F)C(F)=C1[H]
CS(=O)(=O)C1=CC(NC2=NC(NC3=C4OCCC4=CC=C3)=CC=N2)=CC=C1
[H]OC(=O)C([H])([H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1(O[H])C2=C(O[C@@]([H])(C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(F)=C2[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H]
[H]C1=C2C(=C([H])C(F)=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C(C([H])=C(Cl)C(N([H])[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]