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[H]O[C@@]12C([H])([H])C([H])([H])C(=O)C([H])([H])[C@]11C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3OC([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C([H])=C(OC2=C(I)C([H])=C(C([H])=C2I)C([H])([H])[C@]2([H])N([H])C(=O)N([H])C2=O)C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C2C([H])=C(N([H])C([H])([H])C3=C([H])N(N=N3)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C(Cl)C2=NC([H])=C1C#N
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])C1=NN([H])C(=S)S1
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(C(=O)N([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])=C1SC([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
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[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])=C(C(=O)O2)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NN(\C(S1)=N\C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C2=C1[H]
[H]N([H])C(=N\N=C(/[H])C([H])([H])C([H])([H])OC1=C([H])C(OS(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N(N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=S)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])C(Cl)(Cl)P(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C(=O)N([H])C1=O
[H]N(C(=O)N([H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])SC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C(I)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C(SC([H])([H])[H])S1)C1=C([H])SC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(N([H])C2=NSN=C2N([H])[C@@]([H])(C2=C([H])C([H])=C(O2)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H])C(F)(F)F
[H]OC1=C([H])C2=C(O[H])C(=C1[N+]([H])([H])C([H])([H])C([H])=C([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@]([H])(O[H])[C@]([H])(\C([H])=C(C([H])([H])[H])\[C@]([H])(OC(=O)N([H])[H])[C@@]([H])(OC([H])([H])[H])\C([H])=C(\[H])/C(/[H])=C(/C(=O)N2[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]\C(=C(\[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])[C@@]1([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])N([H])C1=NC([H])=NC2=C1C1=C(C([H])=C([H])C([H])=C1[H])N2C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C([H])=C(SC([H])([H])[H])C([H])=C2[H])C2=C1C1=C(N([H])C(=O)C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])N=C(C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C(\[H])=C(/[H])C1=C(N(C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])O\N=C1\C2=C([H])C([H])=C([H])C([H])=C2[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12OC([H])([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])SC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1
CN(C)C1=NC2=C(C=CC(Br)=C2)C2=C1N=C(N2)C1=CC=CC=C1Cl
[H]OC(=O)C1=C(SC2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]N([H])C([H])([H])[C@@]1([H])C2=C3C(OC([H])([H])[C@]3([H])C([H])([H])C1([H])[H])=C([H])C([H])=C2OC([H])([H])[H]
[H]N([H])C(=NOC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(OS(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=N\OC([H])([H])[H])\C2=C([H])C([H])=C(F)C(Cl)=C2[H])C([H])([H])C1([H])[H]
CC(C)C[C@H](CO)NC1=NC(=NC2=C1SC(=O)N2)[S+]([O-])CC1=CC=CC=C1
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[H]\C(=C(\[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C(Cl)C3=C([H])C([H])=C2C([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1(\C([H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]S\C(=N/C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])N2C([H])=NC4=C2C([H])=C([H])C([H])=C4[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H]
OCC1=CC=C(NC(=O)NC2=CC=C(C=C2)C2=NC(=NC(=N2)N2CCOCC2)N2C3CCC2COC3)C=C1
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C(=NN2C2=C([H])C([H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])([H])[C@]([H])(F)C([H])([H])N2[H])=C([H])C(O[H])=C1[H])C1=C([H])C(Br)=C([H])C(Cl)=C1O[H]
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[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(Br)C(Br)=C(Br)C(Br)=C12
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[H]OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])[C@@]([H])(O[H])C1=C(SC2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])F
[H]N(C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C2C([H])=NN(C2=N1)C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])O1
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[H]OC(=O)C([H])([H])C1=C([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C2N=C(SC2=C1[H])C([H])([H])[H]
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[H]OC([H])([H])C1=NC(=C([H])C([H])=C1[H])C1=NN2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
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[H]\C(=C(\[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=N1
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C2C(OC([H])([H])C2([H])[H])=C(C([H])=C1Cl)C(=O)N([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C(=C1C(=O)C([H])([H])[H])C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C12
[H]C1=NC(=C([H])C([H])=C1[H])C1=NC(=C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])N1C([H])([H])[H])C1=C([H])N=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)N1[H])C1=C([H])N=C([H])C([H])=C1[H]
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[H]N1C(=O)N([H])[C@@]2(C1=O)C1=C([H])C(SC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C2([H])[H]
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[H]N(C1=NC(=C([H])C(=N1)C1=C2C([H])=NN([H])C2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
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[H]OC1=C2C(N([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])[H])=C(Br)C([H])=C1[H]
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[H]C1=C([H])C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C1OC(=O)C([H])=C2N([H])C1=C(Cl)C([H])=NC([H])=C1Cl
[H]C1=C([H])C(Br)=C(\N=C2/SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C([H])=C(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C(=O)C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
CN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)C1=C(CC2=CC=CC=C2)C=CC=C1
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=NC([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C(F)(F)F
COC1=CC=C(\C=N\NC2=NC3=C(N=CN3[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)C=C1Cl
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(O[C@]2(C1=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(Br)=C1/OC(=O)[C@@]([H])(C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1(O[H])C2=C(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])=C(F)C([H])=C2[H]
[H]OC([H])([H])C1=C([H])C(=NC2=C(C(=NN12)N([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C(SC([H])([H])[H])C([H])=C3[H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])[H]
FC(F)(F)OC1=CC=C(NC(=O)NC2CCN(CC2)C(=O)C2CC2)C=C1
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N=C([H])C([H])=N1)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C(Br)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]SC([H])([H])[C@]([H])(N([H])[H])C([H])([H])N([H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C3OC([H])([H])C([H])([H])C([H])([H])C3=C12)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NN=NN1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N1C2=C(C3=C1C([H])([H])C([H])([H])N([H])C3=O)C([H])([H])C([H])([H])C1=C2C([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C(C([H])=C(F)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@](O[H])(C([H])([H])N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(F)(F)F
[H]N([H])N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C([H])=C(Br)C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1O[H])C1=C([H])C([H])=C(S1)C(\[H])=C1/SC(=S)N(C1=O)C([H])([H])C(=O)O[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1N=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@@]([H])(C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C2N(C(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C1=NN=NN1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3N=NC4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C([H])=C4C(=N3)C([H])=C([H])C([H])=C4[N+]([O-])=O)C([H])([H])[C@@]12O[H]
[H]N(C(=O)[C@@]1([H])N(C([H])([H])C(=O)C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
FC(F)(F)C(=O)C1=CC=C(C=C1)C(=O)N1CCOC2=CC=C(C=C2C1)C1=CN=C2C=CC=CC2=C1
[H]N(C(=O)C1=C(N(N=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@]([H])(N(C1=C(F)C([H])=C([H])C(F)=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=NN(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C2=NC3=NC([H])=NC(N([H])[H])=C3C(=C2[H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]O[C@@](C(=O)N([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])[C@]12[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])OC1=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C(=NC(=N1)C([H])([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
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[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])/C([H])([H])[H]
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[H]N(C(=O)N1C([H])([H])[C@@]2([H])C(=O)N(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(N([H])N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C(=C(/[H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C([H])([H])C1=C([H])C([H])=C([H])S1
[H]C1=C([H])C2=C(OC([H])([H])O2)C(=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1Cl
[H]N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])N=C(C([H])=C12)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C(=O)N(C2=NOC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2=C([H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C(=N1)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(F)C(=C1F)C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])[C@]1([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
[H]OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])OC2=C(SC3=C([H])C([H])=C([H])C(F)=C3[H])C([H])=C(C([H])=C2[H])C2=C([H])SC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1F
[H]C1=NC(=C(C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC(=NC4=C3C([H])([H])C2([H])[H])C(F)(F)F)N1C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C(=O)C1=C(N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(N2C([H])=C(C([H])=C([H])C2=N1)C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C(=O)C1=C(F)C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1F
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)N([H])C2=NC([H])=C([H])C([H])=C2[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])N1C(=NC2=C1N=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(N([H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C1[H])C([H])([H])[H]
[H]N1C(=O)N(C2=NC(=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2OC1=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=NC([H])=C1C1=C([H])C([H])=C([H])O1
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C(=O)N(C([H])=C2[H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C(=O)N([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)OC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
CCC1=C(F)C(OC)=NC(=N1)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=CC(F)=CC=C1F
[H]OC1=C(C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]OC1=C2C(OC(=C2C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C(Cl)C([H])=C1Cl
[H]OC1=C(C([H])=NC2=NC(Br)=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]4([H])[C@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]4(C(=O)OC([H])([H])N4C(=O)C5=C(C([H])=C([H])C([H])=C5[H])C4=O)C([H])([H])C([H])([H])[C@@]32C([H])([H])[H])C1(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])O\N=C(\C2=C(C([H])=C([H])S2)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C1=O
[H]C1=C(I)OC(=N1)C(=O)[C@@]1([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C(F)(C2=NC(=NO2)C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1Cl
[H]C1=C([H])C(=C([H])C([H])=C1F)N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(SC#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C1([H])C([H])([H])C1([H])[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(N=C(C(=N1)C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C3=NC(=C([H])S3)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=N1)C(F)(F)F)C1=C([H])C2=C(N([H])C(=O)C2([H])[H])C([H])=C1[H]
N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N1CCN(CC1)C1=C2C=C(C=CC2=NC=N1)C1=CC=CC=C1
[H]OC1=NC([H])=C([H])C2=C(OC(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C12
[H]OC([H])([H])C1=C([H])C([H])=C2C(=C1[H])N(C([H])=C2[C@@]([H])(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C1=O
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2=N1
[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]C1=C(N=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H]
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[H]OC(=O)C1=NN([H])C(=C1Cl)C([H])([H])[H]
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[H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
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[H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C(N([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])=C([H])C([H])=C1[H]
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[H]OC1=C([H])C([H])=C2C(OC(=O)C([H])=C2C([H])([H])SC2=NC([H])=C([H])C([H])=N2)=C1[H]
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[H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
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[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
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[H]O[C@]1([H])C2=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C(=C(N=C2C([H])([H])[C@]2(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(F)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=NN=C([H])N2[H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2N([H])C(=O)C2=NC(Br)=C([H])S2)C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])SC1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N1C(=O)C([H])=C([H])N=C1N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C3N=C([H])SC3=C12)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])S(=O)(=O)C2([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=NC([H])=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
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[H]OC1=C([H])C([H])=C2SC(=O)OC2=C1[H]
[H]OC([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C4N=C([H])SC4=C23)C([H])=C1[H]
[H]OC1=NN2C(=N1)C(=C(N=C2C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1
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[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C(N([H])[C@@]([H])(C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])[N+]([O-])=O
[H]O[C@]([H])(C([H])([H])OC1=C2C(N([H])C(=O)C2(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2([H])ON=C(C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])[C@]1(C2=C([H])C([H])=C(F)C([H])=N2)C([H])([H])C2([H])N(C([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C(Cl)C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])C(=O)C(=O)OC([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C(=O)C2=C(C([H])=C(N([H])C(=O)C3=C(F)C([H])=C(C([H])=C3F)C(=N[H])N([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(I)C([H])=C(C([H])=C1I)C(=O)C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F)C1=C2C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=NO[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])N=C([H])N=C2[H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(C#C[H])=C([H])C([H])=C3[H])C2=C1[H]
[H]N([H])C(=O)C([H])([H])N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N1\C(=N/OC([H])([H])C([H])([H])[H])C([H])=N[C@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]\C(C1=NC(OC([H])([H])[H])=C([H])C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
[H]N(C1=NC(=C([H])C2=C1N([H])C(=C2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C(F)C(=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(SC([H])=C2C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
CN1C=C(C=N1)C1=CC(F)=C(CN2C(=O)C(O)(C3=CC=CC=C23)C(F)(F)F)C=C1
[H]O[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C(S1)C1=NC(=NO1)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]C1=C(Cl)C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C([H])C(=C([H])C([H])=C2[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12F)C([H])([H])N([H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])S1
[H]N(C1=NC2=C(S1)N=C(N=C2N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]C(C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])([H])C([H])([H])O4)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])=C(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=N1)C(=O)O[H]
[H]O[C@@](C([H])([H])N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN2C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(Cl)=C2C(=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])(N1C2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[C@@](C1=C([H])C([H])=C([H])C(F)=N1)(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]\C(C1=C([H])C([H])=C([H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)C1=C([H])N(C2=NC(Cl)=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(=C2[H])S(=O)(=O)N([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(=C([H])C(Cl)=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])C([H])=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NOC2=C([H])C([H])=NC([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(SC(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C(C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C2OC(=O)C([H])=C([H])C2=C1[H]
[H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C([H])=C(Br)C([H])=C2C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C(=O)OC([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1=O)C1=C([H])C([H])=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])([H])C#CC([H])([H])C#CC([H])([H])O\N=C1/C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C2N=NN(C2=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(OC(=O)C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H]
COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C3=C(CC(CC3)C(=O)NS(C)(=O)=O)C2=C1
[H]N([H])C([H])([H])[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])F
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]N1[C@]([H])(SC([H])([H])[C@@]1([H])C(=O)C1=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(Br)=C2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=NC(=NC2=C([H])C([H])=C(C([H])=C12)C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(F)(F)F)C([H])([H])C#C[H])N([H])[H]
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[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])S[C@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
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[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=N2)C([H])([H])[H])=C1[H]
[H]N1C(SC2=C([H])C([H])=C(O2)C(\[H])=C2\C(=O)N([H])C(=O)N(C2=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])=NC2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C(\SC1=C(N([H])[H])C([H])=C([H])C([H])=C1[H])=C(/C#N)\C(\C#N)=C(/SC1=C(N([H])[H])C([H])=C([H])C([H])=C1[H])N([H])[H]
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[H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC2=NC([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
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[H]N(\N=C(\C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C(=O)N([H])C1=NN([H])C(=S)S1
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[H]N(C(=O)C1=C([H])OC([H])([H])C([H])([H])O1)C1=C([H])C(=O)\C(C([H])=C1[H])=C1/SC2=C([H])C([H])=C([H])C([H])=C2N1[H]
[H]O[C@@](C([H])([H])C1=C([H])C([H])=C(C([H])=O)C([H])=C1Cl)(C([H])([H])C(C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]C1=NC2=C([H])C([H])=C(C([H])=C2N=C1[H])C1=C(C(=O)N(N1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H]
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[H]N([H])[C@]([H])(C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]OC(=O)[C@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])N([H])C(=O)[C@]2([H])N(C(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]3([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C4=C([H])C([H])=C(O[H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C(=C([H])C2=C([H])C([H])=C([H])C(OC3=NC([H])=C(C([H])=C3[H])C(F)(F)F)=C2[H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C1SC(C#C[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N=C2[H]
[H]N(C(=O)N1C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
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[H]N1C2=C([H])C([H])=C(C([H])=C2C(O[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(C#N)=C1[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)N1C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
CC(C)NC1=C(N=C2C=CC(C)=CN12)C1=CC=C(OCC2CCN(CC2)C(=O)NC2=CC=C(Cl)C=C2)C=C1
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)O1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C2=C([H])C(Br)=C([H])C([H])=C2N=C1C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
COC1=CC=C(Cl)C=C1NC(=O)NC1=C2C=CC=CC2=NC(=C1)C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C1=C([H])C(O[H])=C(C(=O)C2=C(N([H])C(=O)C([H])([H])[H])C([H])=C([H])C([H])=C2O[H])C(O[H])=C1[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=NC(=N2)C2=C([H])C(=NC(=C2[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]OC(=O)[C@]12O[C@@](O[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1(O[H])C(=O)O[H])(C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])[C@@]2([H])OC(=O)C(\[H])=C(/[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(OC(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]2([H])O[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=C(COC2=CN=C(N=C2)N2CCN(CC2)C(=O)OC(C)(C)C)C=CN=C1
CC(C)COC1=C(C=C(C=C1)C1=NC=NC(O)=C1)C#N
[H]OC1=C(C([H])=NC(=C1[H])C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)F)C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C(\[H])=C(/[H])C1=C(N=C(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])N(C1=C([H])C([H])=NN1C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C(O[H])=C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C2C3=NN(C4=C([H])C([H])=C(C#N)C(=C4[H])C([H])([H])[H])[C@]([H])([C@@]3([H])C([H])([H])C([H])([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C2=NC3=C(C(F)=C([H])C([H])=C3N2[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])[C@@]([H])(C(=O)N([H])OC([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])[C@]([H])(O[H])[C@]1([H])C([H])([H])N([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C2=C1N([H])C1=C([H])C([H])=C(C([H])=C21)C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)N([H])[H])N1N=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]SC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C(N([H])C2=C1[H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C(=O)N2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C(C3=C1C([H])=C([H])C(OC1([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])=C3[H])C([H])([H])C([H])([H])SC2([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C3[H])=N1)C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C(N(N=C2C(=O)OC([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(O[H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C([H])([H])[H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])F)C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2N([H])C(=O)C(=C([H])C2=C([H])C(=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])SC2=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(C#CC2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=N1
[H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(N4C(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C5([H])[H])C([H])([H])[C@@]4([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C(C([H])=C1C1=C([H])C(=NC(=N1)C#N)C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C2C([H])=NC([H])=C([H])C2=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[C@@]3([H])OC([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(OC([H])([H])C([H])([H])O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])[C@@]3([H])N(C(=O)C([H])([H])[H])C4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(OC([H])([H])[H])C([H])=N1
[H]N([H])C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C([H])=C([H])N3[H])C2=C1[H]
[H]N(C(=O)[C@@]([H])(C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]OC(=O)[C@]12O[C@@](O[C@]([H])(C3=NC(=NO3)C([H])([H])[H])[C@@]1(O[H])C(=O)O[H])(C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])[C@@]2([H])OC(=O)C(\[H])=C(/[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]O[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])[C@@]1([H])F)C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C(=O)N1C([H])([H])C2=C(C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C([H])=C([H])[C@]1([H])N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NN=C(S2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N(C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C3=C1OC([H])([H])C3([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[N+]([O-])=O
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C1([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC1=C2C([H])=C([H])C([H])=C([H])C2=C(N([H])S(=O)(=O)C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1Cl
[H]O[C@]([H])(C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=C1N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
Cc1ccc(cc1)C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12
[H]N1C([H])=C(C(=O)C(F)(F)F)C2=C1C1=C(C([H])=C2[H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]N([H])C(=O)C1=C2N([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]12[H])C1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])([H])[H])C2([H])[H]
[H]N1C(=NC2=C1C([H])=C(C(=O)OC([H])([H])[H])C(Cl)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2F
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(=O)N(C2=C3C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@@]2([H])SC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C(C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)\C=C\S(C)(=O)=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(=C([H])C3=C([H])C([H])=C([H])N=C23)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=NC([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Br)C([H])=C(\C([H])=C(\C#N)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(C2=C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C3(C([H])([H])C3([H])[H])C2([H])[H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=C(Br)C([H])=C(Cl)C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C3=C(N=C([H])N3[H])C([H])=C12
[H]C1=NC(=NC([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C(F)(F)F
[H]N(C(=O)N([H])[C@](C1=C([H])C([H])=C(Cl)C([H])=N1)(C1=C([H])C(F)=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C1([H])[H])[N+]([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C([H])([H])C4=C5C([H])=C([H])C([H])=C([H])C5=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]N([H])C1=C([H])C(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]OC1=C([H])C(=O)N(C2=NC(=NC(=C12)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1
CC1=C([C@H](N2N=CC=C2N1)C1=CC=C(Cl)C(Cl)=C1)C1=NC=NN1CCC(F)(F)F
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2OC([H])([H])[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(N=C3C(F)=C(N(C([H])([H])[H])C([H])([H])[H])C(F)=C(F)C3=C2C([H])([H])[H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(N2C(=O)C3=C([H])C(OC4=C([H])C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3N([H])C(=O)C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C2=C(C(=NC([H])=N2)N2C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(C3=C([H])C(F)=C(Cl)C([H])=C3[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N([H])C(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])N([C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])N=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(SC([H])=C2[H])C(=N1)C1=C([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(N([H])C2=C([H])C([H])=C([H])N=C2[H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C(C2=NOC(=N2)[C@@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])[N+]([H])([H])[H])C(F)=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C1=C2N=C([H])C([H])=C(C2=C([H])C([H])=[N+]1[O-])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C([H])([H])[C@]2([H])N([H])C1=NC(=O)[C@](S1)(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C2=C([H])C([H])=C([H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
COC1=CC=C(F)C=C1C(C)(C)CC(O)(CC1=CC2=CN=CC=C2N1)C(F)(F)F
[H]OC1=C(\C([H])=C(/[H])C([H])([H])N([H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(=C2[H])C(F)(F)F)C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C(=C1[H])C1=NN([H])C2=C1C([H])=C([H])C(N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])=C2[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2SC3=C(N=C(N([H])C3=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NN(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1
[H]C1=C(F)C(F)=C(F)C2=C1N1C(=N2)C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H]
[H]N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(Br)=C(S1)C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]OC(=O)C1=C([H])C(=C([H])C(N([H])[H])=C1C([H])([H])[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]\C(=C(/C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(C([H])=C34)C3=NN=C([H])N3C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(Cl)C([H])=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C(Cl)S2)C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=C(F)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC([H])([H])[C@@]12O[C@@]([H])(C([H])=C1[H])[C@]1([H])C(=O)N(C(=O)[C@]21[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C(=O)C2=C(I)C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C([H])=C3[H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N(C(=O)C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])[C@@]([H])(N([H])C(=O)C1=C(Cl)C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])\N=C(\C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N([H])\C(=C(\[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O
[H]OC(=O)[C@@]([H])(N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C(SC(=S)N1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])N=C(Cl)C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C([H])=C(C([H])=N4)C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])[C@@]4(OC(=O)C([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(=C(/[H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C([H])([H])C1=C(C([H])=C([H])S1)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(F)C([H])=C3Cl)C3=C(C([H])=C([H])N=C3N2C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
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[H]OC([H])([H])C1=C([H])N(N=C1C(F)(F)F)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C2([H])[H]
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[H]N([H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C#N)C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C(O1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]OC(=O)C([H])([H])SC1=NN=C(SC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])S1
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[H]C1=C([H])C([H])=C(Br)C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1(C([H])([H])N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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