[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C2=C(\[H])C([H])([H])N2C(O[H])=NC3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C#N)C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])N(C(=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])[H]
[H]N1C([H])=C(N=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]N1C2=C(N=C1[C@@]1([H])C([H])([H])C([H])([H])[C@]3(OC(=O)C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=N1)[C@@]([H])(O[H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N(C(=O)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C(=O)C2=C([H])C([H])=C(C#N)C([H])=C2[H])N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=NN([H])N=N1
[H]N([H])C1=C(C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])N([H])C(=S)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(O[C@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C(OC2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[C@]2([H])C([H])([H])[C@]3([H])N([H])[C@@]2([H])C([H])([H])C3([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C1(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N(C3=C(C([H])=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])C([H])([H])[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])SC(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]N(C(=O)C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=NC2=C(C(=NS2)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N1[H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(Br)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[S@@](=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])N([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])N([H])[C@]([H])(C(=O)OC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N=NN1C([H])([H])C(=O)N(C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])[C@@]([H])(C1=NC(=C([H])N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([C@]1([H])ON=C(C(=O)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])(C(F)(F)F)C(F)(F)F
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N\C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=S)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C([H])=C([H])C([H])=C2C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O)[C@@]1([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C([H])N2[H]
[H]N1C2=C(C([H])=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C([H])=N3)C2=NC([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N=C(SC([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(N3C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[C@@]3([H])C3=C([H])C([H])=C([H])C4=C3N2C([H])=C4[H])C1=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(Cl)C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(Cl)C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C(=O)[C@]2(C1=O)C([H])([H])C1=C(N=C3C([H])=C([H])C([H])=C([H])N3C1=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]21[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])=C1/C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]O[C@](C#C[C@]1(OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=N[H])N([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2(C#N)C3=C(SC([H])([H])C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)N(O[H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H]
[H]OC1=C([H])C([H])=C2OC(=O)\C(=C(/[H])C3=C([H])C([H])=C(O[H])C(O[H])=C3[H])C2=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C(=O)C1=NC([H])=C([H])S1
[H]C1=C([H])C2=C([H])C([H])=C(OC3=C([H])C(C#N)=C(C#N)C([H])=C3[H])C([H])=C2C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C(OC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)N(C(=O)C1=C([H])C([H])=C(SC2=C(SC3=C2C(=O)N([H])C(=N3)N([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[H]
[H]OC1=C([H])C([H])=C2C3=C([H])C(O[H])=C(O[H])C([H])=C3N(C2=C1O[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(O[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=NN(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])C(F)(F)C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C2C([H])=NC([H])=C([H])C2=NC(=C1C#N)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N([H])N=C1[H]
[H]OC(=O)C1=C(C(=C(N1C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C3[H])[N+]([O-])=O)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(N=C1C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])S[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])SC1=NC(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)OC1=C([H])C([H])=C(OC2=C(Cl)C([H])=C(C([H])=N2)C(F)(F)F)C([H])=C1[H])C([H])([H])[H]
[H]N=C(N([H])[H])N(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])N=C(SC2=C([H])N=C([H])C(Cl)=C2C([H])([H])OC2=C3N=C(C([H])=C(C4=C([H])C([H])=NN4C([H])([H])[H])C3=C([H])C([H])=C2[H])C([H])([H])[H])S1
[H]OC(=O)[C@@]1(F)[C@]2([H])C([H])([H])[C@@]([H])(O[C@@]([H])(C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])[H])[C@@](N([H])[H])(C(=O)O[H])[C@]12[H]
[H]N1C([H])=C(\C([H])=C2\N(\C(=N\C([H])([H])[H])N([H])C2=O)C([H])([H])[H])C2=C1C([H])=C(Br)C([H])=C2[H]
[H]N(C(=O)C1=C([H])N=C(N=C1C(F)(F)F)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1\C(=N\C(=O)C2=C([H])C([H])=C(S2)C2=C([H])N([H])N=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2N1C1=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C1=C(N([H])C2=NC(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(SC2=NC(=C(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N12)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]C([H])([H])OC1=NO[C@]([H])(C1([H])[H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=NN(C2=NC([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C(OC([H])([H])[H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)C2=C(N)C=CC=C2Cl)CCN(C)CC1
[H]OC1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)OC([H])([H])C1=C([H])C(=O)C(O[H])=C([H])O1
[H]N(C1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])(F)F
[H]OC([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=O)C([H])=C2C2=C1C1=C(C3=C(C([H])=C([H])C([H])=C3[H])C1([H])[H])C1=C2C([H])([H])N([H])C1=O
[H]N(C1=C2N=C3C([H])=C([H])C([H])=C([H])C3=C2N=C([H])N1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C(N(C2=NC(=NC(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
CC1(C)CC2(N=C(N)N(CC(F)(F)F)C2=O)C2=C(O1)C=CC(=C2)C1=CC(Cl)=CC=C1
[H]C([H])=C([H])S(=O)(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN([H])C(OC([H])([H])[H])=C1[H])C1=C(Br)C([H])=NC(=N1)N([H])[C@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2C(=C1[H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C3=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C2([H])[H]
CC(=O)NCCC1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C(O[H])=C3[H])N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C2=NC(=NN2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(N([H])C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(N(C(=O)N(C2=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C(\C([H])=C(/[H])C2=C([H])SC([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H]
[H]O[C@]([H])(C([H])([H])N(C(=O)C1=C([H])C2=C(N=C(O2)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=NC([H])=C2C([H])=C1[H])[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)[C@@]3([H])OC([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3=C2C2=C([H])N(N=C2C([H])([H])C3([H])[H])C([H])([H])[H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C(=N2)N([H])C2=C([H])C(=C([H])C([H])=C2F)C([H])([H])[H])C([H])=C1[H]
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])C(=C([H])[C@@]23[H])C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
CC(C)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(F)c1
[H]N=C(N(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N(C1=C(Br)C([H])=C([H])C(Br)=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]O[C@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])SC([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])N=C(N=C12)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C2=C(C3=C(C([H])=C2[H])C2=C([H])C(F)=C([H])C(=C2OC3([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
FC1=CC=C(OC2=NN3C=CC(=O)C(=C3C=C2)C2=C(F)C=CC=C2F)C(F)=C1
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])N=C([H])C(Br)=C1[H])C([H])=O
[H]OC1(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])S[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]ON([H])C(=O)C1=C([H])N=C(N=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C(N(C1=S)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=C(C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C(O[H])C2=C(C([H])=C1[H])C([H])=C(N=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C(=O)C2([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C3=C(C([H])=C([H])C2=N1)N(C([H])=C3[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(N([H])C(=O)C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N1N=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(C3=C([H])C([H])=NC([H])=C3[H])=C(C([H])=C12)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C3([H])[H])C([H])([H])[H]
C[N+]1=C(CCC(=O)NCCOCCOCCOCCOCCOCCOCCN2CCN(CC(=O)N3C4=C(C=CC=C4)C(=O)NC4=C3N=CC=C4)CC2)C=C\C1=C\C1=CC=C(N1[BH-](F)F)C1=CC=CS1
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(C#CC3=NC([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[C@]2([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C3([H])[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C([H])([H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C1=NC(N([H])C2=C(F)C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])[H])C(=O)N2[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])N(C1=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C1=NC([H])=C([H])N1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N(C1=C([H])C([H])=C2N(C(=O)N=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(SC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NOC([O-])=N1)C([H])([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
COC1=CC=C(CN2CCC(CC2)N2CC(OC2=O)C2=C3C=C(OC)C=CC3=NC=C2)C=C1
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(N=C(N(C2=O)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(\C([H])=N\N=C(/S[H])N([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C2C(=C1O[H])C1=C(O[H])C3=C(C(=O)C4=C(C([H])=C(O[H])C(=C4O[H])C([H])([H])[H])C3=O)C(OC([H])([H])[H])=C1C([H])([H])C2([H])[H]
[H]N1C([H])([H])C2=C(N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]OC([H])([H])C1=C([H])N=C(S1)C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Br)S1
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Br)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H]
[H]N1N=C(C2=C1C1=C([H])C(=C([H])C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C(=C1[H])C1=C([H])C2(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]1(C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=N1
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C(=O)C([H])([H])SC1=NN=C(N1C([H])=C([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NC([H])([H])C([H])([H])N12
[H]C1=C([H])C([H])=C(C(=C1[H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N([H])C(=O)[C@@]4([H])N(C(=O)[C@@]5([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])SSC3([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C2([H])[H]
CN1CCN(CC2=CC=C3N=C(C)C4=NN=C(N4C3=C2)C2=CC=CC=C2Cl)CC1
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(C2=C([H])N=NS2)\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C(F)C([H])=C23)C([H])([H])[H])C1=O
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]N(C(=O)C1=C(C([H])=C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=C(C#N)C3=NN=C(N3C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C([H])C2=C1C(=O)N(S2)C1=C(Cl)C([H])=C([H])C(Cl)=C1[H]
[H]N([H])C1=C([H])C2=NSN=C2C([H])=C1Br
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]1([H])OC2=C([H])C(=C([H])C([H])=C2C(=O)C1([H])[H])C([H])([H])[H]
[H]OC(=O)C1=NC(C2=C([H])SC(=N2)C([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NN([H])C(=C3[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]SC1=NN=C(N1N([H])[H])C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C2=C([H])C(Cl)=C([H])C([H])=C2C(=O)C(=C1C(=O)OC([H])([H])[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2OC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(N=C1Cl)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
NS(=O)(=O)C1=C(F)C(F)=C(C(F)=C1F)S(=O)(=O)CCO
[H]N([H])N1C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]11N([H])C(=O)N([H])C1=O
[H]O[C@]([H])(C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC2=C(N=C(C(=O)N2[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=N1)C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1Cl
[H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C2=NC([H])=C(C([H])=C12)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])N1C(=O)N(C(=O)N(C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OS(=O)(=O)C1=C(N([H])[H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H]
[H]N1C([H])=C([H])C2=C(N=C([H])N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(C(Cl)=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])[C@]2(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=NC([H])=C([H])C([H])=C12)[C@]1([H])C2=C([H])C([H])=C([H])C(C3=NC4=C([H])C([H])=C([H])C([H])=C4N3[H])=C2C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C([H])([H])S[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@]1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC4=C([H])C([H])=C(F)C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])([H])[C@]2([H])C3=C([H])C(=C(Br)C([H])=C3[C@@]([H])(C([H])([H])[H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C(F)=C(F)C(F)=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])=C([H])[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C(SC([H])([H])[H])S1)C1=C([H])SC(=N1)N([H])[H]
[H]N(C(=O)C1=C([H])N=C(N=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC(=O)CC1=C(C=CC=C1)C1=CC(C)=C(C=C1)C(CN)CC1=CC=C(OCCOC2=C(Cl)C=C(C)C=C2Cl)C=C1
[H]N([C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C([H])C3=C(C([H])=C2[H])N(C([H])=C3[H])C([H])([H])[H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=NC(=N2)C2=C([H])C(=NC(=C2[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C2C(=O)N(C([H])([H])OC3=C([H])C([H])=C(Cl)C(C(=O)N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C3Cl)S(=O)(=O)C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2O1
[H]N(C(=O)C([H])([H])N1C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])OC(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@]3([H])C4=C([H])C([H])=C([H])[N+]([O-])=C4C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C#CC2=NC([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1)N([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H]
[H]N1N=C(Br)C2=C([H])C([H])=C([H])C(C#N)=C12
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2C(=S)S\C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C2=O)C([H])=C1[H]
[H]OC(=O)C1(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CCC1=C(C=CC=C1CCCC(O)=O)C1=CN(N=C1)C1=CC=C(OC(C)C)C(=C1)C#N
[H]OC1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])SC2=C([H])C([H])=NC([H])=C2[H])=C1C([H])([H])[H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(OC(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C(C(=C1[H])C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=C(N2C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C([H])N=C2N([H])N=C(C3=NC4=C(N3[H])C([H])=C([H])C([H])=C4C([H])([H])OC([H])([H])[H])C2=C1[H]
[H]N([H])C(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]SC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=NO1)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(\[H])=C(/[H])[C@@]12C([H])([H])C([H])([H])[C@@](C3=NC4=C(N3[H])N(C(=O)N(C4=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])S1(=O)=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H]
[H]C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1OC([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N2C3=C1C([H])=C([H])C([H])=C3N([H])C(=O)C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=C(C3=C([H])N=C(N=C23)N([H])C([H])([H])[H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC(C)N1CCC(CC1)OC1=CC2=C(NC3=C2CCNC3=O)C=C1
[H]OC1=C([H])C([H])=C2OC([H])([H])[C@]([H])(N(C([H])([H])C(\[H])=C(/[H])I)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H]
[H]OC(=O)C([H])([H])C1=NN(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])S(=O)(=O)C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C(=C([H])C(F)=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C1=NC([H])([H])C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[P@@](=O)(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])=O
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
COC1=CC=CC(=C1)C1=C(C=C(N1)C1=CC=NC=C1)C(N)=O
CN1N=C(CC(=O)NC2=CC=CC(Cl)=C2)C2=CC=CC=C2C1=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C(C([H])([H])[H])(C(F)(F)F)C(F)(F)F)C1=NN=C(S1)C(F)(F)F
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C(=C([H])C([H])=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=NC([H])=C([H])C(=N2)C2=C([H])C(=C([H])N=C2[H])C([H])([H])OC([H])([H])\C([H])=C([H])\C([H])([H])OC([H])([H])C2=C([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C2N=C(C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C2=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C(N=C(S2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C#N
[H]N(C(=O)C1=C([H])C(C#CC2=C([H])C3=C(N=C2[H])N([H])C(=O)N3[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N1[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(N4C(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])OC([H])([H])C5([H])[H])C([H])([H])[C@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(SC2=C1[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])S[C@@]([H])(C1=C([H])C(\C([H])=C(/[H])C2=NC3=C([H])C(Cl)=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([O-])=O)(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]ON(\C([H])=C(\[H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])N([H])C(=O)N([H])C(=O)C2([H])[H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C([H])=C(C([H])=NC2=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
C[C@@H](OC[C@]1(CC[C@@H](CN1)NC(C)=O)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
[H]OC([H])([H])[C@@]([H])(N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])=NC([H])=C2[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])[H])C1=C(Br)C([H])=C([H])C([H])=C1Br
[H]C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1N=C(C([H])=C1C([H])([H])[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]1(O[H])C([H])([H])[H])C([H])([H])OC(=S)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=NN1[H])C1=C([H])C(F)=C(Cl)C([H])=C1Cl
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C(=O)N1C(=O)[C@]([H])(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C([H])([H])C(=O)C1([H])[H])C([H])([H])C(=O)C([H])([H])[H]
[H]N1N=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])N=C12)C(=O)C1=C(F)C([H])=C(Br)C([H])=C1F
[H]N([H])C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C21
[H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)N2N=NC3=C2N=C(C([H])=C3[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C(Cl)=C(Cl)C(Cl)=C2[H])C(=N1)N([H])[H]
[H]C1=C(Cl)C([H])=C(OC([H])([H])[H])C(=C1[H])C1=NC(=NN1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@@]2([H])O[C@@]([H])(C([H])([H])N3N=C([H])N=C3[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N([H])C(=O)C1=C(N([H])[H])C(=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]OC([H])([H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])[C@@]1([H])C([H])([H])SC([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=C([H])N=C(C(OC([H])([H])[H])=C2C([H])([H])[H])C([H])([H])[H])C(Cl)=N1
ClC1=C(Cl)C(=CC=C1)N1CCN(CCCCNS(=O)(=O)C2=CN=CC3=CC=CC=C23)CC1
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])[H])C2=C([H])N=C([H])C([H])=C12
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C(Cl)C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N1C(=O)[C@]2(N(C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C2([H])[H]
[H]C#CC([H])([H])N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1[N+]([O-])=O)[N+]([O-])=O)C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)[C@]1([H])N2C(=O)[C@]([H])(N3C(=O)[C@@]4([H])N(C(=O)C3([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[C@@]2([H])SC1([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N1CCN(CC1)C1=CN=C2C=CC=CN12
[H]N([H])S(=O)(=O)C1=NN2C(=N1)C(=C(N=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1
[H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C4=C(C([H])=C([H])C([H])=C4[H])C3=O)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=NC([H])=C2C(=O)N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])N3C2=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C(=O)N(C1=C([H])C(O[H])=C([H])C([H])=C1C(=O)O[H])C1=C2C([H])=C(O[H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])N(C2=C(C(=C(S2)C2=C([H])C([H])=C(N([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C(Cl)=C(Cl)N=C(Cl)C1=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C(=O)N([H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1(C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C(C#N)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=O
[H]N(C1=C([H])C(Cl)=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C([H])=C([H])C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12
[H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C([H])([H])Cl
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])=C(S2)C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]\C(=C1\C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])C2=C([H])N(N=C2[H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]O[C@@]1([H])C(=O)N(C(=O)C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)[C@]2(C3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])N(C(=O)C2([H])[H])C([H])([H])C1=C(ON=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N1C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2C(C#N)=C1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
NC(=O)C1=CC(OC2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=CC=C1
C[Si](C)(C)C#CCCCCC(=O)C1=NC=C(O1)C1=CC=CC=N1
[H]OC([H])([H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])C([H])([H])N([H])C1=C([H])C2=C(C([H])=N1)C(=NC([H])=N2)N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C(=C(/C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])\C([H])([H])[H]
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C(SC([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2F)=NC2=C([H])C([H])=C([H])C([H])=C12
[H]N(C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(O[C@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C1=C2N=C([H])C([H])=C(C2=C(OC2=C(Cl)C([H])=C(Cl)C(Cl)=C2[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(SC(F)=C4F)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=NC2=C(S1)C([H])([H])C1=C2C([H])=C([H])C(OC([H])([H])[H])=C1[H]
COC(=O)C(N1C(C2=CC=C(Cl)C=C2)C(=S)NC2=CC(F)=CC=C2C1=O)C1=CC=C(Cl)C=C1
[H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C(N([H])C([H])([H])[H])N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=NOC([H])=C1[H]
COC1=CC=C(OC2=C(Cl)C=NN(CC3=CC=CC4=NC=CC=C34)C2=O)C=C1
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C2C([H])=C(N=C=S)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]([H])(N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C3=C(N=C(O3)N3C([H])([H])C([H])([H])[N@]4C([H])([H])C([H])([H])[C@]3([H])C([H])([H])C4([H])[H])N=C2[H])C([H])=C1[H]
[H]C1=C(N2N=NC3=C2N=C(C([H])=C3N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(C(=O)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C2N(N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2C1=NN=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])N(N=C(C2=C(N=C(S2)C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]O[C@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])C3=NN4C(=C([H])C([H])=C4C4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])=N3)C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])[H])=N1)C([H])([H])[C@]([H])(Br)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C1=C([H])C2=C([H])C([H])=C(C([H])=C2S1)C(=O)OC([H])([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C2N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])N([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]11C(=O)N(C2=C([H])C([H])=C(O[C@]([H])(C([H])([H])[H])C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)C2=C(C3=C(N(C4=C([H])C([H])=C(C([H])=C34)C(=O)C3=C([H])C([H])=C([H])S3)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C3=C2C2=C([H])N(N=C2C([H])([H])C3([H])[H])C([H])([H])[H])C1([H])[H]
[H]N([H])C1=C(N(C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])O2)C([H])([H])C([H])([H])OC([H])([H])[H])C(=O)N([H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C(C([H])=C(C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])C([H])([H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])S(=O)(=O)C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC([H])([H])[H])=C([H])C([H])=C1[C@]1([H])C([H])([H])[C@@]1([H])C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C#N)=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC(Br)=C([H])C([H])=C1[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C1=C([H])SC([H])=C1Br
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=C([H])C(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/C#N)C(=O)N([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])C(=O)C(\C#N)=C(/[H])C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])C([H])=C1O[H]
[H]N(C(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N1C(=O)C([H])=C([H])C2=C1C([H])([H])[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]2(\N=C(/[H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])\C1=C(/[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C(O[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]OC1=NSC(N([H])C2=C(C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)=C1C#N
[H]C([H])(C#CC([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(SC3=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C23)C(=O)N([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=NN3C(N(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=NC(N2C([H])([H])[C@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@]3([H])C2([H])[H])=C2N=C(OC2=N1)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N([H])C1=NC(=C([H])C([H])=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1(N([H])C(=O)C2=C(OC([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C([H])C([H])=C(C([H])=C([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C(=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(\C([H])=C2/SC3=NC(=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(N3C2=O)C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=NC3=C([H])C(=C([H])C([H])=C3N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]C1=NN(C2=C1C1(OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)\N=C1\SC(C(=O)OC([H])([H])C([H])([H])[H])=C(N1C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C3OC(=C([H])C3=C12)C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=NC(=C([H])C(=C2N=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=C([H])N(C2=O)C([H])([H])C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])\C(=N\C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])\N=C1/N3C(=NC4=C1C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])N1C(=N2)C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C1=C(N=C2[H])C([H])=C([H])C(C#CC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C([H])C([H])=C(Br)C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H]
[H]OC(=O)C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])N=C([H])N12)\C([H])([H])[H]
[H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC1=NC(=C(C2=C([H])C([H])=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=NC([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C(=C(C([H])=C2N([H])C(=O)C1([H])[H])C(F)(F)F)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(I)=C([H])C([H])=C1[H])C1=C2N=C([H])N(C2=NC(Cl)=N1)[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1)C1=C([H])N([H])C([H])=N1
[H]N1C([H])=NC2=C1N=C(N=C2C#N)C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N(N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)C(=O)N([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)[C@]1(O[C@]2([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]C1=C([H])C2=C(C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])N1C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O2
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C1=C([H])C([H])=C([H])C3=C1[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C(=O)[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C2C([H])=NC([H])=C([H])C2=NC(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1C#N
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C(Br)=C([H])C([H])=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]C1=C(N(C2=C1C([H])=NC(=N2)C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=NOC(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C(Cl)N=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]N([H])C(=O)C1=C2C(OC([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C(F)C([H])=C4[H])C2([H])[H])=C(F)C([H])=C1[H]
[H]N(C1=NC(=NN1C(=O)C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC(=O)N(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C(F)(F)C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=NC(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C(Cl)N(C2=NC(=C(N12)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@]4(C([H])=C([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1O[H])[C@]([H])(N([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C2=C(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C13)C([H])([H])C([H])([H])N=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC([H])([H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N=C(N2C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C2=NN=NN2[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])=C(C2=C([H])C(F)=C([H])C([H])=C2[H])C2=C([H])C(F)=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=C([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]O[C@@]1([H])C([H])([H])N([C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C(OC([H])([H])[H])N=C([H])C([H])=N1
[H]N([H])C1=C2N=C(N=C2N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C(OC([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC([H])=C1[H])N([H])[H]
[H]OC12C(=O)C(=C([H])C1([H])C13OC4(OC([H])(C1([H])C([H])=C(C([H])([H])OC(=O)C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C2([H])[H])C(O4)(C(=C([H])[H])C([H])([H])[H])C([H])([H])C3([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1=C(C(=O)N([H])C2=C([H])N=C([H])C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C3=C2N1C([H])([H])C3([H])[H]
[H]OC1=C([H])C2=C(N([H])C3=C2C2=C(C(=O)N([H])C2=O)C2=C3C(O[H])=C([H])C([H])=C2O[H])C([H])=C1[H]
[H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C1([H])[H]
[H]OC(=O)[C@](N([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@]1([H])O[C@@]2(C3=C([H])C([H])=C([H])C([H])=C3C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CCCCN1CCN(CC1)C(=NO)C1=CC=C(C=C1)C#C[C@]1(CN2CC3=C(C=C(OC)C=C3)C2=O)NC(=O)NC1=O
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#C[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])[C@]1([H])C2=C(C(Br)=C([H])C([H])=C2[H])[C@@]2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)N([H])[C@@]1([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]1([H])C4([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C([H])=C([H])C(=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])[S@](=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(C([H])([H])SSC([H])([H])[C@@]([H])([N+]([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])SC(OC([H])([H])[H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)C(OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(C(F)=C3[H])C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]\C(=C1\C2=C([H])C([H])=C(Br)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N([H])N=C([H])C2=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=N2)C([H])([H])[H])=C1[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=C2C(OC(=O)C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C3=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])O1)C1=C(OC([H])([H])[H])N=C(N=C1OC([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=NC2=C([H])C([H])=C(Cl)C([H])=C2C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4C([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]4([H])C5([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C(SC3=C2N=C(OC([H])([H])[H])C([H])=N3)C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3C(Cl)=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C(F)=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(C1=C([H])C2=C(SC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C2([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]12C([H])([H])C3=C(N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[C@]11C3=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3C([H])([H])[C@@]2([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])C([H])([H])N([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=NC([H])=C([H])C(=C1[H])C1=NC([H])([H])C2=C1C(OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NC([H])=C2[H]
[H]OC1=NC2=NC3=C(C([H])=C2N1C([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C([H])=C3[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])N=C(C2=C(SC(C#CC([H])([H])N3C(=O)C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C([H])=C([H])C([H])=C4[H])=C2[H])N2C(=NN=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])=C([H])S1
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1I)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])C([H])([H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]OC(=O)[C@]([H])(SC1=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(Cl)=N1)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C(SC(=N2)C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C(S1)N([H])N=C2C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])P(=O)(OC([H])([H])[H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]C1=NC([H])=C(N=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])N=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C#CC([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1=NC2=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(\C([H])=C5/SC(=NC5=O)N5C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2N1[H]
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])F)C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]OC(C(=O)O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C([H])S1
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S(F)(=O)=O
[H]OC(=O)C([H])([H])C1=C([H])\C(=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C12
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C(Cl)=C3[H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C1=NC([H])=NC2=C1C1=C(S2)C([H])([H])N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])\C([H])=C([H])/C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C2=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C2=C(N=C(C([H])=C2C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
NS(=O)(=O)C1=C(F)C(F)=C(SCCO)C(F)=C1F
[H]N1C([H])=C(C2=C([H])C(Cl)=C([H])N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(F)C([H])=C1Cl
[H]O[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C2=C([H])N=C([H])N=C2[H])C([H])=C([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=NN=C(S1)C1=NC([H])=C([H])N=C1[H]
COC1=CC2=C(N(CC2)C2=NC(Cl)=CN([C@@H](COCCF)C3CC3)C2=O)C(Cl)=C1
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(S2)C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C(=NC3=C1C([H])=C(N3C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@]1([H])[C@]([H])(O[H])[C@]([H])(O[C@@]1([H])N1C([H])=C([H])\C(=N\OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])C1=O)C([H])([H])O[P@@](=O)(O[H])OP(=O)(O[H])O[H]
[H]OC1=C2C([H])=NC([H])=C([H])C2=NC(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C#N)=C1C#N
[H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2[C@]([H])(SC3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])N1C(=O)C2=C(N=C1C([H])([H])N1C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=NN2C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])N1[H]
O=C1C=C(OC2=C1SC=C2C1=CC=NC=C1)N1CCOCC1
CC1=C(CCN)[Se]C(N)=N1
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=O)[C@]([H])(N(C(=O)[C@@]1([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
NS(=O)(=O)C1=CN(C=CC1=O)C1=CC=C(C2=NON=C12)[N+]([O-])=O
[H]OC(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(\S[H])=N\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])[C@]1([H])C([H])([H])[C@@]1(C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])S1
[H]OC(=O)C1=C(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C(N([H])S(=O)(=O)C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(C([H])=C(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1=C([H])C([H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])N([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=N[C@]([H])(N(C(=N1)N([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])[C@]2(C(=C([H])C1=O)[C@]([H])(OC([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])C(=O)[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H])C([H])([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C12
[H]N([H])C1=C([H])C(=C(C(=N1)C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C(=O)C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C([H])=C([H])C([H])([H])N(C([H])([H])C1=C(N=C(S1)N([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C(C([H])=C1[H])C1=NN=C(O1)C1=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2\C(=O)C3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])=C1[H]
[H]N1C(=O)\C(=C(\[H])C2=C(C(C(=O)OC([H])([H])C([H])([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])N2C3=C(OC([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C3C1=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C(Cl)C([H])=C2[H])C2=C1C([H])([H])[C@@]([H])(C2([H])[H])[C@@](F)(C(=O)OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N(C(=S)N(C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(F)=C1[H])C1(C2=NN=C3N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N([H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@](N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=N1
[H]SC([H])([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H]
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]1(C([H])([H])C([H])([H])N2C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2([H])[H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]