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[H]C1=C(C([H])=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]OC1=C(Br)C([H])=C(C([H])=C2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])=C1Br
[H]N([H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])N2N=C(N=C12)C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H]
[H]OC(C1=NC([H])=C(C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)C4=C([H])C5=C(OC([H])([H])O5)C([H])=C4[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H]
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[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H]
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[H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NN(C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C([H])C2=C(N=C1[H])N([H])N=C2C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(\C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
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CC(C)C1=CC=C(\C=C2\C(C)=C(CCC(O)=O)C3=CC(F)=CC=C23)C=C1
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@]1([H])N(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])[C@]1([H])C2=NC([H])=C(Br)C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
COC1=CC=C2C(SC3=C2N=CN=C3NC2=CC=C(F)C=C2F)=C1
[H]N(C(=O)C(N([H])C(=O)C([H])([H])C(F)(F)F)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C(S1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C1N=C([H])C([H])=C2[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
[H]N(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C2=C([H])C([H])=C(Br)C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])\C(=N/C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])\N=C1/N3C(=NC4=C1C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N1C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C(=NC1([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1SSC1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=NC2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])OC2=C([H])C([H])=C(F)C(F)=C2[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H])C([H])([H])N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
COC1=C(F)C2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C4CCC5(NC(=O)NC5=O)C4=C3)C2=O)C=C1
[H]N(C(=O)C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C1(OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=C([H])C2=C1[C@]([H])(C([H])([H])N([H])C2=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)O[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=NC(=C([H])S2)C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@](O[H])(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)OC2([H])[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C3=[N+](C([H])=C([H])[C@]3([H])N=C2[H])S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])=C(S1)C([H])([H])[H]
[H]C1=C([H])C(SC([H])([H])[H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
CN(C1CCN(CCCN2C(=O)COC3=C2C=CC=C3)CC1)C(=O)CC1=CC=CC=C1
[H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)N(C(=C2C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C3C(ON=C3C([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C(=O)C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC(=NC2=C1C([H])([H])C([H])([H])N(C1=NC([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]ON([H])C(=O)C1=C(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N([H])C1=C([H])C2=C(N([H])C3=C([H])C([H])=C(F)C(Cl)=C3[H])C(C#N)=C([H])N=C2C(Cl)=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
NS(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F
[H]N(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C3N=C([H])SC3=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC(=C([H])O1)C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(N([H])C2=C1[H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(SC([H])([H])C(=O)OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C1=NC([H])=C(N1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C(SC2=C1C([H])=C([H])C(=N2)C1=C([H])C([H])=C([H])S1)C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C1=C(N2[H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]