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[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)OC([H])([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)N([H])[C@]([H])(C(\[H])=C(/[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(F)(F)F
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[H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N([H])C1=C2N([H])C(=C([H])C2=NC(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])\N([H])[N+]([O-])=O
[H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)[C@]1(C([H])([H])[H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
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[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C(Cl)C([H])=C3[H])=NN=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
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[H]N([H])C1=C([H])C(=C(N([H])C(=O)N([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])C(F)(F)F)C([H])([H])C2([H])[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C(=N1)C(=O)N([H])C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C(C#N)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C2([H])[H]
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[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C(N=C2C([H])=C([H])C(=C([H])N12)C1=C([H])N=C([H])N1C([H])([H])[H])N([H])C1=NN([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=NC(N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])=C1C(=O)N([H])N([H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(\[H])C1=C([H])N(N=C1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(\N=C(\C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H]
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[H]OC([H])([H])C(N(C([H])([H])[H])C([H])([H])C1=NOC(=N1)C([H])([H])C1(C([H])([H])C1([H])[H])[C@]1([H])N([C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N1N=C2C(=O)N(C(=O)C2=C1C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
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[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=C(F)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=NC([H])=C([H])C([H])=C2C1=O
[H]OC([H])([H])C(=O)N1C([H])([H])C2=C(N(N=C2C2=C([H])C(SC([H])([H])C(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[C@]([H])(O[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O[H])C(O[H])=C(O[H])C(OC([H])([H])[H])=C2O1
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[H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)N1C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C(OC2=C([H])C(F)=C([H])C(F)=C2[H])C(=O)C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C(Cl)=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(C#CC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C12
[H]OC1=C([H])C(\N=C2/SC(=NN2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H]
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[H]N(C1=NC(=NC(=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Cl)=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
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[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])[H])C([H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=N1
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N2C(=O)S\C(=C(\[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C2=O)C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])OC3=C([H])C([H])=C(\C([H])=N\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C12)C([H])([H])[H]
[H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])=C([H])C([H])=C(C2=O)C2=C([H])C(N([H])[H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(OC3=C([H])C([H])=C(Cl)C(Cl)=C23)C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2/OC(=O)N(C2=O)C2=C([H])N=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1Br
[H]C1=C(C([H])=C([H])C(Cl)=N1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])S[C@](C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C2=C(N=N1)C1=C(C([H])=C([H])C([H])=C1[H])C2=O
[H]\C(=C1/C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C2C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C(OC(=N1)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])=C([H])C2=C1C([H])([H])[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@]22N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C1=C(C([H])=C([H])C(OC([H])([H])[H])=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C(F)(F)F
[H]N1N=NN=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C(F)=C3[H])N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)N(C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)O[C@]1([H])C([H])([H])C(OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N(C(=C(C(=O)C([H])([H])C([H])([H])C3=C([H])C(F)=C(F)C([H])=C3[H])C2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(N=C(N1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(N1C([H])([H])[H])C1=C(F)C([H])=C(O[H])C([H])=C1[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C(N([H])[C@]([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])N=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C(C#N)C2=C(S1)N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C2N=C(C(=C(N2N=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
CC1=CC(NC2=NC(NCC3=CC(=NO3)C(C)(C)C)=NC=C2Br)=NN1
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])O[C@]21[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@]1([H])O[C@@]([H])(N2C([H])=C(C(=S)N([H])[H])C3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]N1C2=C([H])C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=C2N=C(C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2N(N=NC2=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)O[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C1([H])[H])C([H])([H])[C@@](N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C3([H])[H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])=N2)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H]
FC(F)(F)C1=CC=CC(=C1)C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CCOCC4)N=C3C=C2)=C1
[H]OC(=O)[C@@]1([H])OC2=C(C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C(OC([H])([H])[H])=C(C([H])=C3[H])C3=C([H])SC([H])=N3)C([H])([H])C([H])=C([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C2=C(N([H])C(=C2[H])C2=C([H])C([H])=C([H])C3=C2C(=O)N([H])C3([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C(S1)N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2C#N)C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=NC([H])=NC(N3C([H])([H])C([H])([H])C([H])(C4=NC(=NO4)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N=N2)C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])S(=O)(=O)[C@]1([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@@]([H])(O[C@]2([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]2([H])OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]1([H])OC(=O)C([H])([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
COC1=CC(OC)=C(\C=C(/C#N)C(=O)NC2=CC=C(C=C2)S(N)(=O)=O)C(OC)=C1
[H]N([H])C1=NC2=C(C([H])=C([H])C(N([H])[H])=C2C([H])([H])[H])C2=C1C([H])=NC1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C21
[H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])[H]
[H]O[C@@]1([H])C2=C([H])C(F)=C(N([H])C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C(Cl)=C4[H])C([H])=C2C([H])([H])C([H])([H])C1(F)F
[H]OC1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C([H])C(=C2[H])N2N=C(C(=O)N([H])C3=NN=C(S3)S(=O)(=O)N([H])[H])C(C(=O)OC([H])([H])C([H])([H])[H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C([H])=C([H])S(=O)(=O)C1=C(C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(Cl)S1)[N+]([O-])=O
[H]\C(C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=NN(C(=C1C(=O)N1C2=C(C([H])=C3C([H])=C([H])N=C(N4C([H])([H])C([H])([H])N5C([H])([H])C([H])([H])C([H])([H])[C@]5([H])C4([H])[H])C3=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H]
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[H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)N(C(=N2)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])OC2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
CC(C)OC(=O)N1C2CC3CC1CC(C2)N3C1=NC=NC(OC2=CC=C(C=C2F)C#N)=C1C
[H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=NN=C([H])N2[H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C(F)=C([H])C([H])=C1C([H])([H])[H]
[H]N([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C(C([H])=C([H])C(F)=C1[H])C(=O)N([H])C([H])([H])C1=NC2=C(S1)C(F)=C([H])C(F)=C2F
[H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C([H])([H])[C@](C2=O)(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N([H])C(=O)N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])N([H])C2=C(C([H])=C([H])C(OC([H])([H])C3=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C3[H])=C2[H])S1(=O)=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]12C([H])([H])C([H])([H])[N@@](C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])[C@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(C2=NN=C(N2C([H])([H])[H])[C@@]23C([H])([H])C([H])([H])[C@@](C([H])([H])C([H])([H])[S@](=O)C([H])([H])C([H])([H])[H])(C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C1=C([H])C([H])=C(SC2=NC([H])=C([H])C([H])=C2[H])C(Cl)=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C1[H])C1=NC([H])=C([H])S1
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=NC3=C(C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C3[H])C(N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2C([H])=C1[H]
[H]O[C@@]1(C#CC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])OC([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])C4=C3[C@@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]12C([H])([H])[H]
[H]N(C1=NC2=C(C([H])=N1)N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC(=C1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C1[H])C([H])([H])C2([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C#C[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=N1)C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(SC(Cl)=C4Cl)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C2(O[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C2=C1OC([H])([H])C21C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C3=C(OC4=C(C([H])=C([H])C([H])=C4[H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C1([H])[H]
[H]N([H])C1=NC(C(=O)N1C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)N(C1=NC2=C([H])C(=C([H])C(=C2S1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(C2=C([H])C([H])=C([H])C(=N2)C([O-])=O)=C(C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C(F)C([H])=C(F)C([H])=C1F
[H]N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])N2C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])S1)C([H])([H])N([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N(C(=O)C([H])([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
NC(CCC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=C(O)C=C1)C(O)=O
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C3N=C2C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C([H])C(=C(N([H])[H])C([H])=C2N2N=C(N=C12)C(=O)OC([H])([H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(S1)C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(OC(=O)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])=C1[H]
[H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=C1[H]
[H]OC([H])([H])C1=C2SC3=C([H])C([H])=C([H])C([H])=C3C(=O)C2=C(N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C(C(=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C(C1=O)=C23
[H]N(C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(SC3=C([H])C([H])=C(F)C([H])=C3Cl)C3=C(C([H])=C([H])N=C3N2C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H]
[H]C([H])=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]4([H])C3=O)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])[C@]1(C2=C([H])C(=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(N=C(N=C2[H])N([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]SC1=NN=C(S1)N([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]SC1=NC(=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(Cl)C([H])=C(C(=O)N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC(=O)C([H])([H])[H])=C1Cl
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H]
[H]C1=NN(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=NC2=C(Br)C([H])=NN12)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])P(=O)(OC([H])([H])[H])OC([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C(=O)O[H]
[H]C1=NN(C2=C1[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C([H])N=C1C([H])([H])[H]
CC(C)C[C@H](CO)NC1=NC(S[C@@H](C)C2=C(F)C=CC=C2)=NC2=C1SC(N)=N2
[H]N(C(=O)C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C3=NC4=C(S3)C([H])=C(OC([H])([H])[H])C([H])=C4[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C([H])C(=C([H])C(OC4=C([H])C([H])=C(Cl)C([H])=C4[H])=C23)C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])[C@]([H])(F)C1([H])[H]
[H]N1C2=C(N=C(N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N(C2=C([H])C([H])=C(C#N)C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(C#N)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC([H])([H])C2([H])[H])=N1
[H]\C(C1=C([H])C([H])=C([H])S1)=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@@]1([H])C3([H])[H]
CC(C)CNc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)S2)[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)\C(=C(\[H])C(=O)C2=C([H])C([H])=C(Br)S2)C2=C([H])C(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[H]
[H]C([H])([H])C1=C(C(=O)ON1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
CN(C)CC[C@H](CSC1=CC=CC=C1)NC1=CC=C(C=C1[N+]([O-])=O)S(=O)(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=CC(=CC=C1)C1=C(N(C)C(C)=C1C(N)=O)C1=CC=C(Cl)C=C1
CCCCCCCCN1C=C(CN(CC)CC)C2=CC(=CC=C12)C1=C(C)C=CC=C1
[H]C1=C(N=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C#N)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1SC(=C2[H])C1=C([H])OC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1N=C(C([H])=C([H])C1=O)S(=O)(=O)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1N=C(N(\N=C(/[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[N+]([O-])=O)C1=S)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#N
[H]C1=NC([H])=C(N=C1[H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C2C3=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N=C3C3=C2C1=C([H])C([H])=C3[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=NC2=C1N=C([H])C([H])=C2[H])C(F)(F)F
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C(N=C1[H])C1=C([H])OC([H])=C1[H])C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2F
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N2C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=O)C1([H])[H]
CC1=CNC2=C1C(=NC=N2)N1CCN(CC1)C(=O)[C@H](N)CC1=CC=C(F)C=C1
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C(=O)C1=C([H])SC(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(SC([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])C(=O)N2C([H])([H])C([H])([H])C3=C(N([H])C4=C3C([H])=C(OC([H])([H])[H])C([H])=C4[H])[C@]2(C([H])([H])C([H])([H])[H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])O3)C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[N+]([O-])=O)C([H])([H])[H]
[H]N1C2=C(N=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H]
CC1=CC=C(\C=C\C(\O)=C\C(=O)C2=CC=CC=C2O)C=C1
COC[C@H]1OC(OCC2=CC=C3C=CC=CC3=C2)[C@H](NCCN)C(OCC2=C3C=CC=CC3=CC=C2)[C@@H]1O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]N(C(=O)OC([H])([H])[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC1=C2N([H])C(=NS(=O)(=O)C2=C([H])C(Cl)=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@](C(=O)N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C2([H])[H]
[H]C1=C([76Br])C([H])=C(Cl)C(=C1[H])C1=C2N=C(N=C(N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(\C(S1)=N\C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(Cl)=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=N1)C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=NN=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]O\N=C1\C2=C(O[C@@]3(C(=O)N([H])C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])[C@@]13[H])C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])[H])C([H])=C(C([H])=C2OC1=O)C([H])([H])[H]
[H]N(N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1F)C(=C1/C([H])=C([H])C([H])=C([H])C1=O)\C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(OC3=C(C([H])=C([H])C([H])=C3[H])[C@]2([H])C(C(=O)N([H])C2=NN=C([H])S2)(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]C1=C([H])C(\N=C2/SC([H])([H])C3(C([H])([H])C3([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(N2C1=NC(=C([H])C2=O)C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]N1C2=C(C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N(C4=C([H])C([H])=C(Cl)C([H])=C4[H])C4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N2C(=S)N([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(S1)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C(C([H])=C2[H])[N+]([O-])=O)[C@@]2(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]22C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C1=O
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H][C@@]1(CCN(C1)C(=O)[C@@H](N)CC1=CC=C(O)C=C1)S(=O)(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
[H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C(=O)C3([H])C([H])([H])C3([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C(=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C#CC([H])([H])N1C(=O)N(C2=C(N(C(=N2)C(\[H])=C(/[H])C2=C([H])SC([H])=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]21[H]
[H]N([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])([H])N1C(=O)C2=C([H])C(I)=C([H])C([H])=C2N(C(=O)[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(F)(F)F
[H]C1=C([H])C2=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=NN(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C2=O
[H]ON(C(=O)N([H])C([H])([H])C1=NC([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C2=C(C([H])=C1Cl)C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])C1=NC([H])=C(S1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])N(C2=NC(=C([H])C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]O[C@@]([H])(C([H])([H])SC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])N([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C(S1)N(C(=O)N(C2=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@@]13O[C@]4(O[C@@]([H])([C@]1([H])C([H])=C(C([H])([H])OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C2([H])[H])[C@@](O4)(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C2=C([H])C3=C(C([H])=C2C([H])=C1[H])C(=O)N(C([H])([H])[H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C2=C([H])C3=C(O2)C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C(N=C(C(=O)N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])[C@]([H])(F)C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]ON1C2=C(C(=NN2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C3([H])[H])C3(OC([H])([H])C([H])([H])O3)C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C(F)C([H])=C(F)C2=C1[H]
[H]OC([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C#CC(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=N/OC([H])([H])C([H])([H])C([H])([H])[H])\C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C2=C([H])N=C(C([H])=C2[H])N2C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(=O)C2=C([H])C([H])=C(C([H])=C2O1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
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[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C2=C([H])SC(=N2)C([H])([H])[H])=C(N1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
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[H]N([H])C1=C([H])N=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
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[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)C1=C([H])[C@@]3([H])C(=O)[C@@]4(OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(C3([H])[H])[C@]14O2)C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])[C@@]2([H])N(C3=C(C(=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(O[C@@]([H])(OC([H])([H])[H])[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=N1
[H]N(C(=O)C1=C(N([H])C(=O)C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C#N)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(C(=O)OC([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])=C(C2=C1C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])O1)C([H])([H])C2=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F
[H]ON1C(=O)[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=NC([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])=C([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@@]12[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C(N([H])C(=O)C2([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1N=NC([H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C(C2=C(N(C1=O)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C(=O)C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C([H])C(=C1C1=C2N=C(C(Br)=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=N1)C(=O)N1C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
O=C1C2=CC=CC=C2OC2=C1C(CN1C=CN=C1)=CC=C2OC1CCCC1
[H]C1=NC2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2N1C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C1=NC(=NC2=C1N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[C@]([H])(C([H])([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])[C@]([H])(N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(N4C(=O)C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])SC2=C1[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
COC1=C(C\C=C(/C)CCC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1
[H]C1=C(N=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])SC1=NC2=C(N=N1)C1=C(C([H])=C([H])C([H])=C1[H])N(C(=O)C([H])([H])[H])[C@@]([H])(O2)C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(N([H])[H])C2=C([H])C([H])=C(O[H])C([H])=C2C1=O
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(C2=C([H])C([H])=C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])C(Cl)=C2[H])=C(C#N)C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C1[H]
COC1=CC2=C(C=C1)N(C(=N2)C1=CC2=CC=CC=C2C=C1)C1=CC=NC(NC2CCCCC2)=N1
[H]OC(=O)C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(O[H])=C2O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]S\C(=N\C1=C([H])C([H])=C(C#N)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C2(OC3=C(N([H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C(Cl)C([H])=C1[H]
[H]C1=NC([H])=C(C2=NC(=C3N2C2=C([H])C(Cl)=C([H])C([H])=C2N=C3C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
CC1=CC=CC(NC(=O)\C=C\C2=CC=C(O)C=C2)=C1
[H]N(C(=O)C([H])([H])OC1=C(F)C(F)=C(F)C(F)=C1F)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])N([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C(F)(F)F
[H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N=C(N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(F)=C(N([H])C(=O)C2=C([H])C(=NN2C2=C(F)C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C4([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])=C([H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H]
[H]N([H])C([H])(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C#N)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(O[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C(I)=C([H])C([H])=C12)C1=C(C(=O)N([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=NC1=NC(=C([H])S1)C1=C(N([H])C([H])=C1[H])C([H])([H])[H])N([H])[H]
[H]N(C(=O)C([H])([H])OC1=C(Cl)C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])N=C([H])C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(O[H])=C1C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
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[H]N(C(=O)N1C([H])([H])C([H])([H])C2(C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])[C@@]1([H])C2=NN=C(N2C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H])C([H])([H])C(F)(F)F
[H]N(C(=O)C(\[H])=C(/[H])C(=O)C([H])([H])[H])[C@]([H])(C1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)O1)C([H])([H])[H]
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[H]O[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N1[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C([H])([H])[C@]12[H])[C@@]([H])(Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C1=C([H])N2N=C([H])N=C(N([H])C3=C([H])C([H])=C4N(N=C([H])C4=C3[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C1C([H])([H])C([H])([H])[H])C([H])([H])[H]
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[H]N(C1=NC2=C(C([H])=N1)C([H])=C(N1N2C([H])([H])C([H])([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1[H]
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[H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl
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[H]N(C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C(S1)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12
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[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
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[H]N=C1OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])=C1C(=O)N([H])C1=C(N=C([H])N1C1=C([H])C([H])=C([H])C([H])=C1[H])C#N
[H]N(C([H])([H])C([H])([H])[H])[C@]12C([H])([H])C3=C(N([H])C4=C3C([H])=C([H])C([H])=C4[H])[C@]3([H])OC4=C5C(=C([H])C([H])=C4OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@@]235
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[H]N([H])C1=NC([H])=NC(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])=C1\C([H])=N\OC([H])([H])[H]
[H]C1=NC(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C2=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(N=C2SC3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@]([H])(O[H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)N([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]N([C@]1([H])C(=O)N(C2=C(F)C3=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1
CC1=C(OC2=CC=C(C=C2)N2C=NN=N2)N=CN=C1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1[C@@]1([H])N(N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])C1=NC(=NC(Cl)=N1)N([H])C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(Cl)=NC2=C1N=C([H])N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O
[H]N(C1=NC(=C([H])C2=C1C(=O)N([H])C([H])=C2[H])C1=C([H])N=C([H])N=C1[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(Cl)C([H])=C([H])C(=C3[H])C(F)(F)F)C2=C1[H]
[H]N1C(=O)C2=NN(C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]OC(C([H])([H])C1=NC([H])=C([H])N1C([H])([H])[H])(P(=O)(O[H])O[H])P(=O)(O[H])O[H]
[H]N(C(=O)C1=C([H])C(=NN1C1=C(C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)[C@@]([H])(N2C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C3=C([H])C([H])=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1N([H])[H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C1=NC([H])=C([H])C([H])=C1[N+]([O-])=O)C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=C2C(=NC3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C(F)C([H])=C2[H]
[H]N1C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N(C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]N(C(=O)C1=C([H])C([H])=NN1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F
[H]C1=C2N(C3=C(C2=C([H])C(Br)=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1C(=O)N([H])[H])C1=NN(\C(S1)=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C(SC(=C1[H])C1=NC(=NO1)C([H])([H])S(=O)(=O)C([H])([H])[H])C(=O)C(F)(F)F
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)N([H])C1=C(Cl)C(Cl)=C(C([H])=C1S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C(Cl)C(Cl)=C(C([H])=C1S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H]
[H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])=NC([H])=N1
[H]N(C(=O)C1=C(OC2=C([H])C([H])=C(C([H])=C2Cl)C(F)(F)F)N=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(ON=C2C2=C([H])C3=C([H])C([H])=C([H])C(O[H])=C3C([H])=C2[H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(C4=C(N3[H])C([H])=C([H])C([H])=C4[H])[C@@]2([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[S@](=O)C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=NC(=N1)C#N)N([H])C([H])([H])C([H])(F)F)C1=C([H])C(F)=C([H])C(F)=C1[H]
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[H]N(C1=NC(=C(S1)C([H])([H])N1C([H])=C([H])N=C1C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)C1=C(N(C(=C1C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])N(C(=O)C2=NC([H])=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])C2=C([H])C(=O)C(SC([H])([H])[H])=C([H])C([H])=C2C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[H])[C@]([H])(N2C([H])=NC3=C(N=C(N=C23)N([H])C([H])([H])C([H])([H])C2=C([H])N(C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N1N=NN=C1C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C(=O)[C@@]([H])(N2C(=O)[C@@]([H])(N([H])C(=O)\C(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])[C@]([H])(OC(=O)[C@@]([H])(N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(/[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]N1C([H])=C([H])C2=C3N(C([H])=NC3=C([H])N=C12)C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NN=C(S1)C(F)(F)F
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])[H])[C@]1([H])N([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(C2=C([H])C([H])=C(S2)C#CC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(=NC(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H]
COC1=NC(=NC(C)=C1F)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=C(F)C=CC=C1F
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(Br)C([H])=C(C([H])=C1[H])[C@]1([H])OC([H])([H])[C@]2(C([H])([H])O[H])C([H])([H])C([H])=C(C([H])([H])[H])[C@@]1([H])C2([H])[H]
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C2=C(C3=C(N2C2=C([H])C(N([H])[C@@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])[H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N=C(SC2=C1[H])S(=O)(=O)N([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]3([H])OC4=C([H])C([H])=C([H])C([H])=C4OC3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C(=O)N(C1=C(C([H])([H])[H])C([H])([H])[C@]([H])(N(C1=O)[C@]([H])(C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C2=C1N=C(O2)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=[N+]1[O-]
[H]N(C(=O)N([H])[C@](C1=C([H])C([H])=C(Cl)C([H])=N1)(C1=C([H])C(F)=C([H])C(OC(F)(F)C([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(F)(F)F
[H]C1=C(C([H])=C2C([H])=C([H])C([H])=C([H])N12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H]
[H]C1=C2C([H])([H])[C@@]([H])(N(C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]34C([H])([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]4([H])[C@]2([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]N1C(=O)C2=C3C4=C(C([H])=C([H])C([H])=C4[H])N4C3=C3N(C5=C(C([H])=C([H])C([H])=C5[H])C3=C2C1([H])[H])[C@@]1(O[C@@]4([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])[C@]1([H])OC([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]23C4=C(C([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])([H])[C@]1([H])[C@]2(OC([H])([H])[H])C([H])([H])C([H])([H])C(=O)C3([H])[H]
[H]OC(=O)C(=C(/[H])C1=C(OC2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2S1)\C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C(=O)C(C2=C([H])OC3=C([H])C([H])=C(F)C([H])=C23)=C(C1=O)C1=C([H])N(C2=C([H])C([H])=C(I)C([H])=C12)C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])[C@@]([H])(O[C@@]2([H])C([H])([H])N([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC3=C([H])C(=C([H])C([H])=C3N2C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C(=O)N([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=NC(=C1C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C(N(N=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OP([O-])(=O)[C@]([H])(C([H])([H])[S@@+](C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])P(=O)(O[H])O[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NC(C2=C([H])N=C([H])S2)=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C1=NN(C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(C#N)C([H])([H])C1([H])[H]
[H]C1=C2OC([H])([H])C([H])([H])C2=C([H])C(=C1[H])C1=NN=C(O1)SC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C([H])S3)C(=O)N([H])C2=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C(OC(F)(F)F)C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C(=NN=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C([H])=C(Cl)C(Cl)=C2N2N=C(N=C12)C(=O)OC([H])([H])C([H])([H])[H]
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[H]N=C1N([H])\C(=C(\[H])C2=C([H])N([H])C3=C2C([H])=C(Br)C([H])=C3[H])C(=O)N1C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(N([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C2[H]
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[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(\N=C(\C1=C([H])C2=C(OC1=O)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
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[H]C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(Cl)(Cl)C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1Cl
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(C(=NN2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C([H])=C([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)[C@]1([H])C(=O)N2C3=C(C([H])=C([H])C([H])=C13)C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H])C1=NN=C(S1)C(F)(F)F
[H]OC1(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])=C([H])S1
[H]OC(=O)[C@@]([H])(N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[C@]1([H])C([H])([H])[H])C1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C3C4=C(C#N)C(=O)N=C4C4=C3C2=C([H])C([H])=C4[H])C([H])=C1[H]
[H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C3C(=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)\C([H])=C([H])/C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=NOC(=N2)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(=C2[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C(C#N)C([H])=C3[H])C([H])=NC([H])=C2S1)C([H])([H])[H]
CC(=O)N[C@@H]1C[C@@H]2CC[C@H](C1)N2CC1=COC2=CC(OC3=NC4=NC=CC=C4S3)=CC=C12
[H]C1=C([H])C(=C2C(=C1[H])[C@](OC2([H])[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H]
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NC[C@@H](C(=O)N1CCN(CC1)C1=NC=NC2=C1C(Cl)=CN2)C1=CC=C(Cl)C(Cl)=C1
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[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
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[H]N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(Cl)=C([H])N(C1=O)[C@@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(OC([H])(F)F)C([H])=C1Cl
[H]N([H])C(=O)C(=O)C1=C(N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]C1=C(N(N=C1C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
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[H]OC1=C(C([H])=C(\C([H])=C(/C#N)C(=O)N([H])[H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]C1=C2C(=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(O[H])O[H])C([H])=C1[H])C1=NC(=NO1)C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
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[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])([H])C(=O)N1[H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=N1)C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@@]4(OC(=O)C([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]O[C@]1(C([H])([H])C([H])([H])[H])C([H])([H])N2C([H])([H])[C@@]([H])(C1([H])[H])C([H])([H])[C@@](C(=O)OC([H])([H])[H])(C1=C(C3=C([H])C([H])=C([H])C([H])=C3N1[H])C([H])([H])C2([H])[H])C1=C(OC([H])([H])[H])C([H])=C2N(C([H])([H])[H])[C@]3([H])[C@@]4(C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C([H])[C@](C([H])([H])C([H])([H])[H])([C@@]41[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]3(O[H])C(=O)OC([H])([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1)C(=O)C([H])([H])C#N
[H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C4=NC5=C(N4C([H])([H])C([H])([H])C3([H])[H])C(=O)N(C(=O)N5C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C(O[H])=C(Cl)C([H])=C1C1=NN([H])C(C(=O)N([H])C([H])([H])C([H])([H])[H])=C1N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C2/SC(=S)N(C2=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[N+]([O-])=O
[H]OC1=C([H])C([H])=C2O[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])[C@]([H])(SC2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])N(C1=NC(=C(N21)C([H])([H])N(C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C(F)(F)F)C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C(Cl)=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C5=C(Br)C([H])=C(C([H])=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(O[H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C(=O)N2C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])[H]
[H]\C(C1=C([H])C([H])=C(Br)S1)=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=NC3=C(OC4=C3C([H])=C(Cl)C([H])=C4[H])C(=O)N2[H])C([H])([H])C1([H])[H]
[H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])SC([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C([H])([H])[H])C([H])([H])C2=O)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]O[C@@]1([H])N([H])C(=O)N(C(=O)[C@]1(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2OC([H])([H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])[C@@](C1=O)(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C(Cl)C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=N1)C([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
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[H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C(N2C([H])([H])C([H])([H])N(C(=O)[C@]3([H])C([H])([H])N(C([H])([H])[C@@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=NN=C1[H]
[H]OC(=O)C1=C([H])N(C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N1C(SC([H])([H])C(=O)N([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])O2)=NC2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C1=O
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[H]O[C@@]1(OC([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C(O[H])=C2C(=O)[C@@]([H])(O[H])[C@]([H])(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C(O[H])=C1[H]
CC1(C)CC2=C3C(SC4=C(NCC5=CC=NC=C5)N=CN=C34)=NC(N3CCOCC3)=C2CO1
[H]OC1=NC2=C(C([H])=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C(N([H])C(=O)C([H])([H])[H])=C1C(=O)C([H])([H])[H]
[H]ON(C([H])=O)[C@]([H])(C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
O=C(NC1=CC=CC=C1)OC1C2CCN(CC2)C1CC1=CN=CC=C1
[H]N(C(=O)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C(=C(OC2=C([H])C3=C(N([H])N=C3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CC([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])N=C1C([H])([H])[H])C(=O)N1C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C(C([H])=C([H])C(Cl)=C2[H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C(=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])N(C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C3([H])[H])C2=NC(=NC([H])=C2C1=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(SC1=S)C1=C([H])C([H])=NC([H])=C1[H]
[H]SC1=NN=C(S1)N([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])O2)C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])(F)F
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C1\C([H])([H])[C@]2([H])[C@]([H])(O[H])C([H])([H])[C@@]([H])(C(\[H])=C(/[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(OC([H])([H])[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC2=C3N=C(N(C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C2N=C3OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C2=C1[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
CC(C)(C)NC(=O)NCCN1CCCC(C1)NC(=O)C1=CC(Cl)=CC(Cl)=C1
[H]N(C1=NC([H])=NC(=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C1(O[H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(F)C(F)=C2N([H])C2=C(F)C([H])=C(I)C([H])=C2[H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C(N=[N+]=[N-])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(C(=O)C2=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C(SC4=C([H])C([H])=C(F)C([H])=C4[H])=C([H])C([H])=C23)=C2N1[C@]([H])(SC2([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=NC(=C(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NC([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])N([H])C1=C([H])C(=C([H])N2C1=NC(=C2C([H])([H])[H])C([H])([H])[H])N1N=C([H])N=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC1=C([H])C(=NC2=C(C(=NN12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C(Cl)C(=C([H])C([H])=C3[H])C(F)(F)F)C(F)=C2[H])=C1\C(=N\[C@]([H])(C([H])([H])[H])C([H])([H])O[H])N([H])[H]
[H]N(C1=NC(=C([H])C(=N1)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=C([H])C([H])=C(C1=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]([H])(N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NOC(=N1)C1(C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]C([H])=C([H])C([H])([H])N1C(=O)OC2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(O[H])=C([H])C(=C2[H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])N([H])C1=O)C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)N(C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(C(=O)N([H])[N+]3=C(C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(C2=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C(Br)=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=NS(=O)(=O)C1=C([H])C([H])=C(N([H])C(=S)N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H])N([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])OC1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)N([H])[C@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C1([H])[H]
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[H]N([H])C1=C([H])C([H])=C(C(=N1)C([H])([H])[H])C([H])([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)O[C@@]([H])(C([H])([H])[H])C1([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C(F)C([H])=C1F)[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C#CC([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@]([H])(C([H])([H])N([H])C1=NC([H])=C(S1)C1=C([H])C([H])=C2N([H])C(=O)N(C2=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=NN2C2([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)[C@@]([H])(N1C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C(\C([H])=C(/[H])C2=C([H])N=C([H])C(=C2[H])C(=O)N([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2N([H])C(=O)C([H])([H])OC2=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]N([H])C1=NC([H])=NN2C([H])=C([H])C(C(=O)N([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])N([H])C(=O)N([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C12
[H]N(C1=C(C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(OC([H])([H])[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O)[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@](C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]C1=C([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2(C2=C([H])C(OC([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=S)N([H])\N=C(\C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])/C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
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[H]C1=C2N=C(C3=C(C(=O)N(C3=O)C([H])([H])[H])C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(C([H])([H])S[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1([H])[H]
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[H]O[C@@]1(C([H])([H])[H])C([H])([H])C2=C(N([H])C3=NC([H])=C(O3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
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[H]OC(C([O-])=O)(C([H])([H])C([O-])=O)C([H])([H])C([O-])=O
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[H]N(C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])C2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1O2)C([H])([H])[N+]([O-])=O
[H]N(C1=N\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C(=O)N1C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(C3=C([H])C(F)=C([H])C(=C3N2[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
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[H]OC1=C([H])C(=C([H])C([H])=C1N([H])[H])C([H])([H])N1N=NC2=C1N=C(N=C2C1=C([H])C([H])=C([H])O1)N([H])[H]
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[H]OC([H])([H])[C@@]([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1Cl)C1=C([H])C([H])=C(C(=O)N2C([H])([H])[C@]3(C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C(Cl)=C1[H]
CN(C)C1CCC(CC1)NC1=C(C=NC(NC2=CC(Cl)=CC(Cl)=C2)=N1)C(=O)NC1CCN(C)CC1
[H]C1=C(Cl)C(N(C2=NC(=C(S2)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C1C1=C([H])C(F)=C([H])C([H])=C1C([H])([H])S2)C(F)(F)F
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC(=O)C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C(=C([H])C([H])=C2C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1Cl
[H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])N1C(=O)N(C(=O)C1([H])[H])C([H])([H])C1=C([H])C(=C(Cl)C([H])=C1[H])[N+]([O-])=O
[H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C(SC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C(=O)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2[C@@]([H])(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])C(=O)C([H])([H])SC2=NC3=C(O2)C([H])=C([H])C([H])=N3)[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12[H]
[H]N([H])C(=O)C1=C(SC2=C1C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])N1C(=O)N([H])[C@@]2(C1=O)C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC([C@]1([H])ON=C(C(=O)N([H])C([H])([H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H])(C(F)(F)F)C(F)(F)F
[H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])N=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C1OC(=O)C(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])[C@]5(C([H])([H])[C@@]35C(=O)C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N=C(SC([H])([H])[C@@]41C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C(C#N)C(=N2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])C([H])=C1[H]
[H]C1=C(SC(=N1)[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=N1)N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C(C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3N=C12)C([H])([H])[N+]1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])N1[H])C1=C(C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]ON([H])C(=O)C1=C([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2C([H])=C1[H]
[H]N1N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=O
[H]N=C(N([H])C1=NC(C2=C([H])N([H])C(=C2[H])C([H])([H])[H])=C(S1)C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=C([H])C([H])=N1
[H]N=C(N([H])[H])N([H])\N=C(/C1=C([H])C([H])=C([H])C(OC([H])([H])C(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C(=N\N([H])C(=N[H])N([H])[H])\C([H])([H])[H])C(=N/N([H])C(=N[H])N([H])[H])\C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]OC1(C([H])([H])N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(OC2=C([H])OC3=C(C([H])=C([H])C(OC(=O)C4=C([H])C(Br)=C([H])N=C4[H])=C3[H])C2=O)=C1[H])C([H])([H])[H]
[H]O[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])[N+]([H])([H])[H])C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H]
[H]O[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]11C(=O)N(C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C2C(=C1[H])C1=C(SC(=N1)[N+]([H])([H])[H])C2([H])[H]
[H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C(=C2N=C(SC2=C1C([H])([H])[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N1C([H])=C([H])C([H])=C1C1=C2C(=O)N([H])C3=C([H])C([H])=C(F)C(=C23)C(S[C@@]2([H])N([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=NC(C2=NN=C(S2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C([H])=C([H])C([H])([H])N1C(=C([H])C(C(=O)C([H])([H])SC2=NC(=O)C3=C([H])C([H])=C([H])C([H])=C3N2[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]\C(=C1\C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C(=O)[C@]2(C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])N=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=NC([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C1=NN=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])C(=C([H])C([H])=N2)C2=C(N=C(SC([H])([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])N=C(N=C12)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])OC(=O)C(\C#N)=C1/S[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[H])C([H])([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2(C(=O)N(C3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC([H])=NC([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C(=O)N(C([H])=C1[H])C([H])(F)F)C(F)(F)F
[H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C(=O)C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(N([H])[H])=[N+]([H])[H]
[H]C1=C(C(=O)C2=C(OC([H])([H])[H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1N=NC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(F)C(=C2N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C2([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]SC([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N(C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C1=C(C(=O)C(=C(C1=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N([H])[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(F)C([H])=C1OC(=O)N1C([H])([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=S)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C1=C([H])[C@]2([H])N(C([H])([H])[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4OC3([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])O[C@@]([H])(OC([H])([H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC(=C([H])O1)C1=NC([H])=C([H])C([H])=N1
[H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(SC([H])([H])[H])C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C3=C(N=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N([H])C([H])([H])C1=C2N(C([H])=NC2=C([H])C([H])=C1C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])N1C([H])([H])[C@@]2([H])OC([H])([H])[C@]1([H])C2([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H]
[H]C1=C(N=C2C([H])=C(C([H])=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N1C(=O)C([H])([H])N(C([H])([H])C([H])([H])C(=O)C2=C(Cl)C([H])=C(C([H])=C2Cl)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2OC1=O)C([H])([H])C([H])([H])[H]
CC1=CC(Cl)=C(OCCOC2=CC=C(CC(CN)C3=C(C)C=C(C=C3)C3=C(CCOC(N)=O)C=CC=C3)C=C2)C(Cl)=C1
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=N[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])O1
[H]N(C1=NC(=NC2=C1N=NN2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C2=C(OC3=C(C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C([H])=NC([H])=C2S1
[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C(O3)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@](C([H])([H])[H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C(N=C([H])N3C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N(C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C3=NC4=C(S3)C(=C([H])C([H])=C4OC([H])([H])[H])C([H])([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
CNC1=NC(CC(F)(F)F)=C(S1)C1=CC=NC(NC2=CC=CC(=C2)S(N)(=O)=O)=N1
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N([H])C(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])N=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])[C@@]2([H])C3=NC([H])=C(Br)C([H])=C3C([H])([H])C([H])([H])C3=C2C(Br)=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C3=C(C([H])=C([H])C2=N1)N(C(=C3[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])(C#N)C([H])([H])C2([H])[H])C(OC2([H])C([H])([H])N(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C2([H])[H])=N1
[H]C1=NC2=C(C([H])=C1Br)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])[C@]2([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=[N+]([O-])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(\C(=N\C#N)N([H])C2=C3N=C([H])N(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)N([H])[C@]2(N(C(=O)N([H])C3=C([H])C([H])=C(OC(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C23)C([H])([H])[H])C1=O
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[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(SC([H])([H])C(C(=O)C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=NN=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1Cl)C([H])([H])[H])[C@@]([H])(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]OP(=O)(O[H])C([H])([H])[P@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])([H])C1([H])[H])N1N=C(C2=C(N=C([H])N=C12)N([H])[H])C1=C([H])C([H])([H])[C@]([H])(C([H])=C1[H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])SC2=NC(=C(S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NN1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(F)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)N(C2=C(C1=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C2([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N(C([H])([H])[H])C([H])([H])C(=O)C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2F)S1(=O)=O
[H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])S2)C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C#N)C(Cl)=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C(F)=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(\C(=N/C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])N=C(N([H])C3([H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C2=C1[H]
[H]N([H])C1=N[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C2=CC3=C(SC=C3)S2)C=C1
[H]OC1(C([H])([H])OC2=NC([H])=C(C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C2=NC3=C(O2)C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC(=C1C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C(C([H])=C34)C3=NN(C([H])=C3[H])C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])C1=C([H])[C@]2(OC([H])([H])C([H])([H])[H])C(O[C@]([H])(C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])[C@@]2([H])C([H])([H])[H])=C([H])C1=O
[H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]N([H])C(=O)C1=NC(=C(C(=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])[H]
[H]N1C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=NC2=C1C([H])=C([H])C(=C2[H])[N+]([O-])=O
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[H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C1=C2OC([H])([H])[C@]([H])(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
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[H]N(C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])OC1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C([H])([H])[H])=C2C(=N1)C(OC2([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])N=C(Cl)C(=C1[H])C1=C([H])C([H])=C2C([H])=NC([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=NC([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])[C@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)N2N=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C(SC([H])([H])C([H])([H])[H])=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC(=NC(=N1)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(SC(=C1C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C(S1)C1=C([H])C([H])=C([H])C([H])=C1N(C2=O)C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=C2C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N1C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=C(O1)C(=O)N([H])C1=C([H])C2=C(OC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]\C(=N/N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H]
[H]C1=NC([H])=C2N1C([H])([H])C1=C([H])C(OC3=C([H])C4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])N3C(=O)C([H])([H])[N@](C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(F)(F)F
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C(\[H])=C(/[H])C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(C(=O)N1C([H])([H])SC([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]OC([H])([H])[C@@]1([H])S[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
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[H]OC(=O)[C@@]([H])(N([H])C1=C([H])C(=O)C(OC([H])([H])[H])=C([H])C1=O)C([H])([H])O[H]
[H]C1=C([H])C([H])=C(O1)C1=NN=C2N(C3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]OC1=C(Cl)C([H])=C(Cl)C([H])=C1S(=O)(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1Cl)C(=O)N([H])C1=C([H])C([H])=C(SC2=NC3=C(S2)C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C1[H]
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[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
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[H]N1C2=NN(C([H])=C2C(=NC2=C1C([H])=C([H])C(F)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=N1)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
CS(=O)(=O)C1=CC(NC2=NC(NC3=C4OCCC4=CC=C3)=CC=N2)=CC=C1
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[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(N([H])C(=O)[C@]2([H])N(C(=O)N([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])[C@]([H])(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(Cl)C([H])=C(C([H])=C1Cl)C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N1SC2=C([H])C(N([H])C([H])([H])C3=C([H])C4=C5C(O[H])=NC(=NC5=C([H])C([H])=C4C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C2C1=O)C(=O)O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC(C#CC2=C([H])C([H])=C([H])C([H])=C2\C([H])=N\N2C(=O)OC([H])([H])C2([H])[H])=C([H])C(=N1)C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])N(C1=NC(=NC2=C1C1=C(C([H])=C([H])C([H])=C1[H])N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C([H])([H])C([H])([H])[H])=NN=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])=C([H])C([H])=N2)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])SC([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])SC([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@]1(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=S)N([H])C([H])([H])[C@]23OC(O[C@@]2([H])[C@]2([H])OC(O[C@]2([H])C([H])([H])O3)(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]OC([C@@]1([H])ON=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H])(C(F)(F)F)C(F)(F)F
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@]([H])(O[H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC4=C([H])C([H])=C5N=C(SC5=C4[H])S(=O)(=O)N([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C([H])([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]C1=C(C([H])=C(F)C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[C@]1([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])C2=C(C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=NO2)C(OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N(C([H])=O)C2=C([H])C(Cl)=C(Cl)C(Cl)=C2[H])=N1
[H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2(N(C3=C([H])C([H])=C(N=[N+]=[N-])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C(=O)N([H])N([H])C(=O)C1=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]N(C(=S)N1N([H])C(=O)[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F
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[H]N(C(=O)C1=NC([H])=C(C#N)N1[H])C1=C(C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H]