[H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(SC3=C([H])C(F)=C([H])C([H])=C23)C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])=C(C4=C([H])N=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]C1=C([H])C([H])=C(C(=O)N2C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H] [H]O[C@@](C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C(F)=C(C([H])=C1[H])C1=C2N(C([H])=C([H])N=C2N([H])[H])C(=N1)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NC2=C(C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=NN=C([H])N1C([H])([H])[H] [H]N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])[N+]2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C(OC(=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NC([H])=N1)C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]C1=C(N=C(S1)N1N=C(C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])O[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] NC(=O)[C@@H]1CCCN1C(=O)CCCNC(=O)C1=CC=CC=C1 [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C2C(=O)\C(OC2=C1[H])=C(/[H])C1=C([H])N([H])C2=C1C([H])=C(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H] OC1=CC2=C(NC3=C2CCN(C3)C(=O)OC2=CC=CC(=C2)C2=CC=CC=C2)C=C1 [H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1\C([H])=C(/[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=NN([H])C2=C1C([H])=C([H])C(F)=N2 [H]N(C(=O)C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(I)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N(C2=NC(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(Br)=C1[H] [H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=C(Cl)C(=NO2)C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] [H]N(C(=O)N([H])C([H])([H])[C@@](N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C(=C1[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C1=O [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC([H])=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(OC2=C(C(F)=C([H])C([H])=C2[H])C([H])([H])N([H])C2=C([H])C([H])=C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C(=C2[H])C(F)(F)F)C([H])=C([H])C(Br)=C1[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(=O)N(C2=C3C([H])=C([H])C(=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C2=NC3=NC([H])=NC(N([H])[H])=C3C(=C2[H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C2=C(C([H])=C(OC([H])([H])[H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC(=O)N1C2=C([H])C([H])=C(N=C2[C@@]([H])(N(C2=NN(N=N2)C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(S1)C([H])([H])N1C2=C(N=C1C(F)(F)F)C([H])=C([H])C([H])=C2[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C(=O)[C@](C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C12)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(SC2=C(Cl)C([H])=C([H])C([H])=C2[H])=NC2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C([H])N=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Br)=C1[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H] [H]N(\C([H])=C1\C2=C(OC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C(C1=O)[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])N=C([H])C([H])=C3[H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=NN([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N1C2=C(C3=C(C([H])=C2[H])C2=C([H])C(F)=C([H])C([H])=C2O\C3=C(\[H])C2=C(Br)C([H])=C([H])C([H])=C2[H])C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C(N=C(S2)C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])=O)C([H])([H])C1=NC2=C(N=C(N=C2N=C1[H])N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C(OC([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C(N=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N(N=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OP(=O)(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]2([H])N(C(=O)[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[N+]3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=NC([H])([H])C1([H])[H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])SC([H])=C1[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(S1)C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)N([H])C1=C([H])C(F)=C([H])C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2O[C@@]3([H])C([H])([H])N(C([H])([H])C4=C([H])OC([H])=C4[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C2C3=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C2=C([H])C1=O [H]OC(=O)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(O[H])C(Br)=C([H])C(Br)=C1[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])C(F)(F)F)C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1OC1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(SC([H])=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])Cl)C1=C([H])C([H])=C(SC2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])=C(C(=O)N=C1SC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])N(N=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C(OC(F)(F)F)C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C1=NN(C(=S)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])S2)C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=NN([H])C(=O)N1[H] [H]N(C(=O)O[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])[C@]1([H])OC2=C(N=NC(SC([H])([H])C([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])[H] [H]OC(=O)C1=C(C2=C(Cl)C([H])=C(Cl)C([H])=C2N1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C([H])=C1N([H])C1=C(N([H])[C@@]([H])(C2=C([H])C([H])=C(F)C(OC([H])([H])[H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(\C([H])=C(/[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C1C(=C([H])S2)C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C(\[H])=C(/[H])C([H])([H])C(F)(F)C(F)(F)C(F)(F)F)[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] COCCCC1=CC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CC=C(OCC3=CC(=NO3)C3=C(Cl)C(F)=CC=C3F)C=C2)=C1 [H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N(C3([H])C([H])([H])C3([H])[H])S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(N([H])C([H])([H])[H])=C2[H] [H]C1=C2N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C(=NC1=C2C(=NN(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])\C(=N/OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(ON=C2C2=C([H])C(F)=C(O[H])C([H])=C2[H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)N1C(=NC(C2=NN=C(O2)C2(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H][C@@]12C[C@H](OC(=O)C3=CC=CC=C3OC)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])=NC([H])=C2S1 [H]OC(=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=C(Cl)C([H])=C(OC([H])([H])C3=C(ON=C3C3=C(Cl)C([H])=C([H])C([H])=C3Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C(F)C(F)=C(F)C(F)=C2F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C([H])C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]O[C@]1([H])[C@]([H])(OC([H])([H])[H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC3=NC([H])=C([H])S3)C([H])=C2[H])[C@]([H])(O[H])[C@@]1([H])O[H] [H]ON(C([H])([H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=C([H])C([H])=C(S1)S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=N2)C([H])([H])C1([H])[H] [H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=N2)[C@@]2(C1=O)C([H])([H])C1=C([H])C3=C(C([H])=C1C2([H])[H])C([H])=C(C([H])=N3)C([H])([H])N1C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(N(C2=NC3=C(N12)C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])[C@@]1([H])O[C@@]2(O[C@]1([H])C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C3=C(C([H])=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@]21C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C(C#N)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C([H])([H])N1C2=NC3=C(N2C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H] [H]C1=C2N=C([H])C(=C(N2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]([H])(N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N([H])[C@@]1(C([H])([H])[H])C([H])([H])N(C2=C([H])C3=C(N2C([H])([H])C2=C(C([H])=C([H])C(F)=C2[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])[C@]2(C(=O)N([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(/C1=C([H])C2=C(C([H])=C1OC([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H] [H]N=C1N([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC2=C1SC([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])N1N=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Br)C1=O)C([H])([H])[H])C([H])([H])[H] [H]O\N=C1\C(\N([H])C2=C\1C([H])=C([H])C(Br)=C2[H])=C1\C(=O)N([H])C2=C([H])C(Br)=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H] [H]N([H])S(=O)(=O)OC1=C([H])C(OS(=O)(=O)N([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC4=C([H])C([H])=C([H])C(=C4[H])C([O-])=O)[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]N(C([H])([H])C1=C([H])C([H])=C2OC(F)(F)OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NC(=NS1)N1C([H])=NC([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(=C1[H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C3SC([H])([H])C([H])([H])C3=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(C#N)=C([H])C(=C1[H])C1=NC2=NC(=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C(=NC(OC([H])([H])[H])=N2)N([H])C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])S2)S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C(=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=[N+](C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)OC([H])([H])[C@@]1([H])C([H])([H])O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C(=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])O[C@@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])C2=C(C#N)C([H])=C([H])C([H])=C2N1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])C1([H])[H] [H]OC(=O)C1=C(C(=O)N([H])C2=C([H])C([H])=C(C(Cl)=C2[H])C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])N2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]ON([H])C(=O)C([H])([H])S(=O)(=O)N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C(C3=C([H])C(=NC([H])=C3N=C12)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=NC([H])=C(C(SC([H])([H])[H])=C2C([H])([H])[H])C([H])([H])[H])C(Cl)=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N2C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C(C#N)C2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])=C([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C2=C([H])C(OC3([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])[H] [H]O[C@](C#CC1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C(=C(N([H])C(=O)C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H])C([H])([H])[H] [H]N1N=C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NN(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]4([H])C([H])([H])C([H])([H])[C@@]5(O[H])[C@]6([H])N(C([H])([H])C7([H])C([H])([H])C7([H])[H])C([H])([H])C([H])([H])[C@@]55C7=C(C([H])=C([H])C(O[H])=C7O[C@@]45[H])C6([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)O[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C(ON=C1C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F [H]OC([H])([H])C1=NC2=C(S1)C([H])=C([H])C(N([H])C(=O)C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C#N)(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H] [H]OC1=C(I)C([H])=C2C(=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] O=C1N(CC2CCCNC2)C2=CC=CC=C2C(C2=CC=CC=C2)=C1C#N CN(C(=O)C1=CC2=C(S1)C1=NC=CC=C1OCC2)C1=CC=CC=C1Cl [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC2=NC([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2N=C(C([H])=C(Cl)C2=C1[H])C1=C([H])C(F)=C(O[H])C([H])=C1[H] [H]N1C([H])=C(N=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1F CN(C)CCCOC1=NC2=C(CCN(C)C2)S1 [H]C1=C(C(Cl)=C(C([H])=C1OC([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C(Br)=C([H])C(=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])SC([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N1N=NN=C1[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(OC([H])([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C4=NC(=NO4)C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])OC1=O [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3[H])[N+](=C3C([H])=C(N([H])[H])C([H])=C([H])C3=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1=NN([H])C([H])=C1[H])C([H])([H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C3=C([H])C([H])=C(O[H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(N=C(N=C2N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])OC1=C2C(=NC([H])=NC2=C([H])C([H])=C1[H])N([H])C1=C([H])C(Cl)=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C(Br)=C(OC2=C([H])C([H])=C(O[H])C(=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1 [H]OC(=O)C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1O[H])C(\[H])=C(/[H])C1=C([H])C(O[H])=C([H])C(O[H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]12[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C(C([H])=NC2=C1C([H])=NN2C([H])([H])[C@]([H])(Cl)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])[C@@](C#CC2=C([H])N=C([H])C([H])=C2[H])(C1=O)C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]C1=NC(SC([H])([H])[H])=NC2=C1C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C3=NOC4=C3C([H])=C([H])C(F)=C4[H])C([H])([H])C1([H])[H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C([H])=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])S(=O)(=O)C2=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(\C([H])=C(/[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(SC2=NC3=C([H])C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])N=NS1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(=C(/[H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])S1 [H]N([H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])O[C@]2([H])C3=C([H])C(=C([H])C([H])=C3N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C([H])C(N(C(=O)N(C([H])([H])[H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])C([H])([H])[H])=C(F)C(F)=C1F [H]O[C@@]1([H])C([H])([H])[N+]2=C3N(C([H])=NC3=C(N=C2[H])N([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C2=C(OC([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]ON([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])OC([H])([H])[H])[C@]1([H])O[H])C([H])=C([H])[H] [H]N1C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C1=C2C(=NN1[H])C([H])([H])C([H])([H])C([H])([H])C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C(=O)C([H])=C2C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C1[C@@]13C([H])([H])C(=O)C([H])([H])C([H])([H])[C@@]1(O[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H] [H]C1=C([H])C(OC2=C([H])C(Cl)=C([H])C([H])=C2Cl)=C(C([H])=N1)C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=NC(=C([H])N=C2C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(N([H])[H])=C2N=C(N=C2N1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NN=C(SC2=C3C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C([H])C3=NC([H])=N2)S1 [H]C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=[N+]([O-])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])OC([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC1=O [H]N([H])C(=O)C1=C([H])C(=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)[N+]([O-])=O [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C2=C(C(=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N(C2=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)C([H])([H])[H])C1=C(N=C2C([H])=C([H])C(=C([H])N12)C1=C([H])N(N=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H] [H]O[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])OC(=O)N(C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])O[H])C([H])=C2[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])N=N1 [H]ON(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]ON(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C2=NN=C(N2C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(=O)NCC4=NC=CC=C4)C=C3)C2=O)N=C1 [H]N(C(=O)C1=C(N2N=C([H])C(=C2N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C([H])C2=C(S1)C1=NC([H])([H])C([H])([H])N1C(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])=C(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1F [H]N(\N=C(/C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=NON=C12)C(=O)C1=NC([H])=C([H])S1 [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])[N+]([O-])=O)C([H])([H])N(C1=O)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=NC2=C1C([H])=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C(=N2)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NC3=C(N2[H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])S1 [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C([H])C(Cl)=C(C([H])=C1O[H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(O[H])C(O[H])=C1[H] [H]N1N=C(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C(C([H])=C([H])C([H])=C1[H])N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1N([H])C(=N\C#N)\N([H])C1=C(Br)C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])C(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C([H])C2=C1C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3(SC2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(C2=C([H])C3=NC(N([H])[H])=C([H])C([H])=C3N2[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(O[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=NN=C(S1)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C21C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C(F)(F)F [H]N([H])C1=NC([H])([H])[C@]([H])(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C(C(N2C3=C(C(=C2C([H])([H])[H])C([H])([H])[H])C(=NC(=N3)C([H])([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])F)C([H])([H])C2([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])[P@@](=O)(O[H])C([H])([H])[H] [H]N(C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=NN2C(=C1[H])C(=C([H])C([H])=C2C#N)N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@]1(O[C@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=NC(=C(S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=NC([H])=C([H])S1)[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])[H] [H]N(C1=NC([H])=NC(=C1C#CC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(\N=C(\S[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C(N([H])C(=O)C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1Cl)S(=O)(=O)N([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C(C([H])=C2OC(=NC2=N1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])O2)C([H])([H])C1([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(OC2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(N(C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C([H])C(F)=C23)C([H])([H])[H])C1=O [H]C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C2=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1S2 [H]OC1=C([H])C([H])=C([H])C([H])=C1C1=NC(=NC(=N1)N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=NC([H])=NC(=N2)N([H])[H])=C1[H] [H]C1=C([H])C2=C3C(=C([H])C([H])=C2O1)C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C3([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C(=NN2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C(OC([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] CCCCCOC(=O)NC1=NN=C(S1)C1=CC=C(C=C1)C(O)=O [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C2N=C([H])N([H])C(=O)C2=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(C(=O)O[H])C1=C([H])C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]OC1=C([H])C2=C(C(O[H])=C1[H])C(O[H])=C(C([H])=N2)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=NC2=C(C(=NN2C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N1[H] [H]N([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C5=C4N([H])C(=O)C5([H])[H])C(Cl)=C3[H])=C12 [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC1=CC=C(C=C1C(=O)NCCC1=CCCCC1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C(Cl)C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N2OC(=O)C(=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C(OP([O-])(=O)OC([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC2=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(OC(=O)C3=C2C(C([H])=C([H])[H])=C([H])C(OC([H])([H])[H])=C3[H])=C1C([H])([H])[H] [H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C(=O)N([H])C([H])([H])C([H])([H])[H])C2=C([H])N=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]O[C@@]1([H])OC([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N([H])[C@@]1([H])C([H])=C([H])C([H])=C([H])[C@]1([H])S2)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]S\C(=N/C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(C([H])=C(N=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]N1C(=O)N(C([H])=C(F)C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(F)C(=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])C(=O)C2(N(C(=O)C([H])([H])C([H])([H])C2([H])[H])C2=C([H])N=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)[N+]([O-])=O)C(=O)C1=C(N=C2C([H])=C([H])C([H])=C([H])N12)C([H])([H])[H] [H]N(C(=S)N([H])[C@@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(N([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C2[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1\C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])C([H])([H])C1=NC(=C(S1)C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C3=C([H])C([H])=C([H])N=C3C(=N2)C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C1([H])[H] [H]N([C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])N(C(=O)[C@@]1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(Br)=C(OC([H])([H])[H])C(Br)=C1[H])C(F)(F)F [H]C#CC([H])([H])N(C1=C([H])C([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]1([H])C([H])([H])[C@](O[H])(C3([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]N1N(C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(I)C([H])=C12)C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])F [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C(C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C(Cl)C(N(C2=NC(=NC(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])C([H])([H])C3([H])[H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])N1C(=O)N([H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C1=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=NN=C(O2)C2=C([H])C(Cl)=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] COC1=CC=C(C=N1)[C@H](C)NC(=O)[C@H]1C[C@@H]1C1=CC=CC=C1 [H]OC1=C([H])C(O[H])=C2C3=C(O[H])C([H])=C(O[H])C4=C3C3=C5C2=C1C(=O)C1=C5C(=C(C([H])=C1O[H])C([H])([H])[H])C1=C(C([H])=C(O[H])C(C4=O)=C31)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1I)[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])SC(SC([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])[C@]2([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])=N1 [H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2Cl)C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)[C@]12[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2N([H])C(=O)C([H])=C([H])C2=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N2C(=O)C(=NC(Cl)=C2C([H])([H])[H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O CC(C)C[C@H](CO)NC1=NC(SCC2=C(F)C(F)=CC=C2)=NC2=C1SC(=O)N2 [H]N([H])C(=S)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] COC1=CC=C2C=C(CN3C=CN=C3)N(C2=C1)C1=CC=C(C=C1)C(F)(F)F [H]N([H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] FC1=CC=CC(=C1)C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CCCCC4)N=C3C=C2)=C1 [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1 [H]OP(=O)(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)N([H])C(=O)[C@@]([H])(OC(=O)C1=C([H])C(=C(N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])[N+]([O-])=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(N([H])C(=O)N([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C1[H] [H]O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C([H])C(=O)N([H])C2=O)[C@]([H])(O[H])[C@]1([H])O[H])N1C([H])=NC2=C1N([H])C(=NC2=O)N([H])[H] [H]N([H])C1=C(C#N)C(=C([H])C(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])[C@]1([H])S[C@@]([H])(C([H])([H])OC(=O)N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=[N+](C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N(C(=O)C(\[H])=C(/[H])C([H])([H])C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])[C@]2(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1N=C(C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CCN(CC)C1=CC=C(CN(C2=CC=C(Cl)C=C2)S(=O)(=O)C2=CC=C(C)C=C2)C=C1 [H]N(C1=C([H])C(=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F)S(=O)(=O)C1=C([H])SC([H])=C1[H] [H]O[C@@]1(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(F)=C1C([H])([H])[H] [H]N([H])C1=NC(=NC(SC([H])([H])[H])=N1)C1=C([H])C([H])=C2C3=C(C([H])=C(Cl)C([H])=C13)C([H])([H])OC2([H])[H] [H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C(=O)C1=C(OC(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=NC2=C([H])C(Cl)=C(Cl)C([H])=C2N2C([H])=NN=C12 [H]N(C(=O)C([H])([H])[H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C(N1C([H])([H])[H])C([H])([H])C([H])([H])C1=NN2C(=N1)C(=C([H])N=C2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=C(C3=NN=C(N3C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@@]1([H])C2=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C(Cl)=C4[H])C([H])=C2C([H])([H])C([H])([H])C1(F)F [H]N1C2=C(C([H])=C([H])C([H])=C2[H])[C@@]2(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)[C@@]22C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C1=O [H]N(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(S1)C1=C2C(=NN1[H])C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C#N)C([H])=C(C([H])=N1)C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])[C@]1([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C2N=C(OC2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(N=C(N=C2O[C@@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(N=C(N1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]C1=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C2OC(=C([H])C(=O)C2=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@](C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(N([H])C(=O)C2=C([H])C(=NN2C2=C(F)C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C2=C(\[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] Cc1cnc(N)nc1-c1c[nH]c(c1)C(=O)NCc1cccc(F)c1 [H]OC([H])([H])C([H])([H])N1C([H])=NC2=C(C1=O)C(N([H])C1=C([H])C([H])=C(I)C([H])=C1F)=C([H])C(=O)N2C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=N1)C([H])([H])C([H])([H])[C@@]2([H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C(OC([H])([H])[H])=C(C([H])=C2F)C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)OC([H])([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1([H])C2=C(O[C@]3(C([H])([H])C([H])([H])C3([H])[H])C1([H])[H])N=C([H])C(=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])SC([H])=N1 COC1=C(Cl)C(=NC(=N1)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=CC=C(F)C=C1F)C1CC1 [H]N(C(=O)C1=C(N(C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]OC(=O)C(SC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]([H])(N(C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1(OC(C2=C([H])C([H])=C([H])C([H])=C12)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1(C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C(N=C12)C1=NN=C2C([H])=C([H])C(Br)=C([H])N12 [H]ON(C(=O)N([H])[H])[C@@]1([H])C2=C(C(OC([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C2=NC(=C([H])C([H])=C12)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2OC([H])([H])[H] [H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C([H])C([H])=C2C(OC([H])=C(C3=C([H])N=C(C([H])=C3[H])N3C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C2=O)=C1[H] [H]C1=C([H])N2C(=NN=C2C2=C([H])C([H])=C3C([H])=C([H])C([H])=C(OC([H])([H])C4(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C3=N2)C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(C#CC2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C(=O)OC([H])([H])[H] [H]N1N=C(N(C1=S)C([H])([H])[H])C([H])([H])N1N=C(C2=C(C(=NO2)C([H])([H])[H])C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]\C(=C(/[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NN(C2=C1C([H])=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C(=N2)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2C([H])=C([H])C3=[N+]([O-])ON=C3C2=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C2C([H])=C1[H] [H]C1=C(N(N=C1C([H])([H])OC1=C([H])C(=C([H])C(F)=C1[H])C1(OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N2C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@@](N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(OC([H])([H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]ON(C(=O)N([H])[H])[C@]([H])(C#CC1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]C1=C(C2=NSC(=N2)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(SC2=C1C([H])=C([H])C([H])=N2)C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])N1C(=O)N2C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1=O [H]N(C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=C1C([H])=C([H])S2)C1=NN=C([H])N1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C(N3C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C2=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(OC2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C([H])N=C1OC([H])([H])C([H])([H])OC1=NC([H])=C(SC([H])([H])[H])C([H])=N1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@@]1([H])O[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] O[C@@H]1COC[C@H]1NC1=C(C=NC(NC2=CC(Cl)=CC(Cl)=C2)=N1)C1=CC=C(F)C=C1 [H]N([H])C1=NC2=C(O[C@@]3([H])C([H])([H])N(C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])[H] [H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C3=C(C([H])=C([H])N=C3[H])[C@]21[H] [H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@@]1([H])[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])[C@]12[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1N([H])[H])C(=O)N([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])=C(OC([H])(F)F)C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(=C(F)C([H])=C3Cl)S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#CC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1OC1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC(=O)C1=C(N(C(=C1C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C3[H])S(=O)(=O)C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H][C@@]12C[C@@H](CCCCC3=CC=CC=C3)O[C@@]3(C1)O[C@]([H])(CCC3(C)C)CC(=O)O[C@@H](CO)CC(=O)O2 COC(=O)C1=CC=C(C=C1NC(=O)C1=CC=C2N=CC=CC2=C1)C1=CC=C(CN2CCC3=C(C2)C=C(OC)C(OC)=C3)C=C1 [H]N(C1=NC([H])=NC2=C([H])C([H])=C(C#CC([H])([H])N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=NC([H])=C([H])S1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N=C(N([H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 COC1=C(OCCON2N=NC3=C2C=CC=C3)C2=C[N]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3 [H]N(C1=C([H])N=C([H])C(=N1)C1=C([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])N=C2[H])=C([H])N=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=N1)N1C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C(=O)[C@@]([H])(N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]\C(=C(\[H])C1=C(C(=O)C(=C(C1=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C(I)=C3[H])C([H])([H])C1([H])[H] [H]O[C@@]12N([H])C(=O)N([H])[C@]1([H])C([H])([H])S[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C1=NC([H])=C([H])O1 [H]N(N([H])C1=C(C([H])=C(C([H])=C1[H])[N+]([O-])=O)[N+]([O-])=O)C(\[H])=C1\C(=O)N(N=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(F)=C(F)C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])C([H])([H])N(C(=O)[C@@]2([H])N(C(=O)C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C1=NN(C([H])=C1Cl)C([H])([H])[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])[N+]([O-])=O [H]C#C[C@]1([H])N=C(N([H])[H])C2=C(C([H])=C([H])S2)C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NOC(=N1)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N([C@]([H])(C4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)C4=C([H])C5=C(OC([H])([H])O5)C([H])=C4[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N(C([H])=C(C(=O)C3([H])C(C([H])([H])[H])(C([H])([H])[H])C3(C([H])([H])[H])C([H])([H])[H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C2C(=C1[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C2=NN(C(=C2C([H])([H])C#N)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] CC1=NN2C(C1)C1=C(OCC2=O)C=CC(=C1)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] COC[C@H](C)OC1=CC(CCC2=CC=C(F)C=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 [H]N(C(=O)C1=C([H])N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=NN=C(SC([H])([H])C(=O)OC2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N1C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(C([H])=C([H])N(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2=NC3=C(OC4=C3C([H])=C(Br)C([H])=C4[H])C(=O)N2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(ON=C1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])[C@@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=N1 [H]N1C([H])([H])[C@]2([H])N(C3=C([H])C(=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C3=C([H])C([H])=C([H])C(=O)N3C([H])([H])[C@]([H])(C1([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(=C([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[P@@](=O)(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C(F)(F)F [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1S2)C1=C2OC(=C([H])C(=O)C2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C(=O)N([H])[C@@]1([H])OC(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])[H])S(=O)(=O)OC1=C([H])C([H])=C(\C([H])=C(/[H])[N+]([O-])=O)C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C(OC1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C(F)=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]N1C2=C([H])C([H])=C1\C(=C1/N([H])\C(\C([H])=C1[H])=C(/C1=N/C(/C([H])=C1[H])=C(\C1=N\C(\C([H])=C1[H])=C2\C1=C(F)C(F)=NC(F)=C1F)C1=C(F)C(F)=NC(F)=C1F)C1=C(F)C(F)=NC(F)=C1F)C1=C(F)C(F)=NC(F)=C1F [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(Cl)=C([H])C([H])=C([H])C2=C1[H])C(=O)C1=NC([H])=C([H])S1 [H]C1=C([H])N=C(S1)C1=NN(C([H])=C1[H])C1=C2C(=NC([H])=C1[H])N(C1=C([H])C([H])=C(C#N)C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(C#N)=C([H])N1[H])C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3S2(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC1=O)C([H])([H])[H] [H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=NC(=C([H])S1)C([H])([H])[H])C([H])([H])C#C[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C(C(=O)C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N2C(=O)N(C([H])([H])[C@]2([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C2N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C(N2N=C1[H])(C([H])([H])[H])C([H])([H])[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] CC1=CC(NC2=NC(NCC3=CC(C)=NO3)=NC=C2Cl)=NN1 [H]\C(=C1\C2=C(SC3=C1C([H])=C(Cl)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C([H])C(F)=C([H])C([H])=C2N(C1=O)C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])N=C([H])C(C#N)=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])N(N=C1C(F)(F)F)C([H])([H])[H] [H]N1C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)[C@]1([H])O[C@@]([H])(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])OC1=C([H])C([H])=C2N=C(SC2=C1[H])S(=O)(=O)N([H])[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NC([H])=C(S2)C2=NC([H])=C(O[H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])=C([H])N=C2[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C2=C(C([H])=C1[H])C([H])=C(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C3(C(=O)N4[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C3([H])[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C1=NC2=C(C([H])=C([H])C([H])=C2S1)C([H])([H])[H] [H]OC1=C2C(N([H])C([H])=C2C(=O)C2=C3N(C([H])=C2[H])[C@@]([H])(SC3([H])[H])C2=C([H])C([H])=C([H])N=C2[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] CCCCCCCN(CC1=CC=C(C=C1)N(CC)CC)S(=O)(=O)C1=CC=C(Cl)C=C1 [H]N([H])C1=C2C(OC([H])([H])C([H])([H])C2([H])[H])=NC2=NC([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])N1N=NN=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=NC(OC3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])C(=O)C([H])([H])[H])=C(F)C(=C2F)C([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1C([H])=C(C2=NC([H])=C([H])C([H])=C12)S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H] CN1CCC(C2=CC=CC=C2)=C(C1)C(=O)OCCC1=CC(C)=CC=C1 [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C2=C(C3=C(S2)N2C(=NN=C2[C@]([H])(N=C3C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C(=C1[H])C([H])([H])N([H])OC([H])([H])C([H])([H])[S@](=O)C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] CC1=NOC(=N1)C1CCCN(CC2=CC=C(C=C2)C2=NN=C3N2C2=CC=CN=C2NC2=C3C=CC=C2)C1 [H]O[C@@]([H])(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[P@@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]2([H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])O2)C1=NN=C(S1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H] [H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)[C@@]1([H])N(C(=O)C(\[H])=C(/[H])\C(\[H])=C(\[H])C([H])([H])[H])C([H])([H])[C@@]2(ON=C(C3=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])[H])=C([H])C([H])=C3[H])C2([H])[H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C([H])=NC([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]21[H] CC(C)CCC1=C(N(N=N1)C1=NC(C)=CC=C1)C1=CC=C2N=CC=NC2=C1 [H]OC([H])([H])C([H])([H])C([H])([H])O\N=C(/C([H])([H])N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=N2)=C(Br)C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC([H])=C(N(C(=O)C([H])([H])[H])C([H])([H])C2=C(O[11C]([H])([H])[H])C([H])=C([H])C([H])=C2[H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])[H])[C@]2([H])[S@@](=O)[C@@]1([H])C([H])([H])[C@]2([H])S(=O)(=O)OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C(Cl)C([H])=C2O1 [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(OC([H])([H])C([H])([H])[H])=NC(OC([H])([H])C([H])([H])[H])=N1 [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=C([H])C(Cl)=C(O1)C1=NC(=NO1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]([H])(N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)C([H])([H])C#N)C1=C(C([H])=C([H])N=C1N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NOC(=N1)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C2C(=O)C(=C([H])OC2=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(C([H])=C(F)C([H])=C3N2C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C([H])C(=C([H])N=C1N([H])C1=C([H])C(F)=C(OC([H])([H])[H])N=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@]([H])(C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] NC1=NC(=CC=N1)N1C=C(C2=C1C=CN=C2)C1=CCOCC1 [H]N(C(=O)C1=C([H])[N+](=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] BrC1=CC(\C=N\NC2=NC3=CC=CC=C3N=C2CC2=CC=CC=C2)=CC=C1 [H]C1=C([H])C(=C(Cl)C(Cl)=C1[H])C([H])([H])N1C2=NC(=C([H])C(=O)N2C(=C1C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=NC([H])=C2C([H])=C1[H])[C@]([H])(C1=C([H])C(F)=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(C2=C([H])C3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]OC([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C2=C([H])C3=C(O2)C([H])=C([H])C(=C3[H])C2=NC([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=NC1=NC(=C([H])S1)C1=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C(N1[H])C([H])([H])[H])N([H])[H] [H]N(C(=O)C1=C([H])N=C(N=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C([H])([H])S[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H] CC(C)(N)C(=O)N1CCC[C@H]1B(O)O [H]OC1=C(C([H])=C(N=C1[H])[C@@]1(O[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N1N=C(C2=C3C1=C([H])C([H])=C([H])C3=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1N=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C(Cl)C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])=C2[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(C(=O)ON1C(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(SC(Cl)=C4Cl)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=NC(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C3C(O[C@]4([H])[C@]33C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C2([H])[H])[C@]32C([H])([H])C([H])([H])[C@@]4(OC([H])([H])[H])[C@@]([H])(C([H])([H])OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C2([H])[H])=C1OC([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NN=C(O1)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])N1C(=O)C([H])([H])OC2=C1C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])SC([H])([H])C([H])([H])C([H])([H])S[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N(C1=N[C@]([H])(C([H])([H])[H])C([H])([H])O1)C([H])(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]O[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC1=NC([H])=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F [H]N(C1=NC(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])=C(C#N)C([H])=N1)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])C1=NC(=C2N1C1=NC(OC([H])([H])[H])=C([H])C([H])=C1N=C2C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]1([H])N(C(=O)[C@]([H])(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C1=O)[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])N([H])[H] [H]OC(=O)C1=C2OC3=C(C([H])=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C3[H])C([H])([H])C([H])([H])C(=O)O[H])C(=O)C2=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3OC([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(Cl)=C1[H] CN(CC1=CC=C(C=C1)C1=NCCN1)C(=O)COCCN(C)S(=O)(=O)C1=C(F)C=CC=C1F [H]OC(=O)C([H])([H])N(C(=O)OC1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(OC(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]2([H])O[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NN1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C(N2C([H])([H])C([H])([H])C([H])(C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C(C2=NN=C(N12)C([H])([H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] OC1=CC=C(C=C1)N1CCN(CC2=CN(N=C2)C2=CC=C(Cl)C=C2)CC1 [H]C1=C(C([H])=C([H])C(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C([H])([H])N(C3=C4C(=NC([H])=N3)N([H])N=C4C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H] CN1CCN(CC1)C1CC2=C(SC3=C1C=C(C=C3)C1=CC=CN=C1)C=CC=C2 [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C3=NC([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C4=C([H])C([H])=C([H])C(C(=O)C2=C1[H])=C34 [H]OC1=C2C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]12O[H] [H]N([H])C1=C(Cl)C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC2=NC3=C([H])C([H])=C([H])C([H])=C3N2C1=O [H]N(C(=O)C1=NC([H])=NC(=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@]([H])(N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N(C([H])([H])C1=C(N=C(S1)N([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P(=O)(OC1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])OC1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C#CC([H])([H])N1N=C([H])C(=N1)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])C(=C2C(=C1[H])[C@](OC2([H])[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])C(=O)C([H])([H])SC([H])([H])C([H])([H])C(=O)N([H])[H])[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12F [H]N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3Cl)C(F)(F)F)C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C12 [H]N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N1C([H])=NC2=C1N=C([H])N=C2SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])C1=C(OC([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(OC([H])([H])[H])=C([H])C(C([H])=O)=C1[H] [H]OC([H])([H])C1=NN=C(S1)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C(=C3[H])C([H])([H])[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])[H])=C([H])C(Cl)=C1[H] [H]N(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN(C([H])=N1)C1=C([H])C(=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=C2/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C23)C(=O)OC([H])([H])[H])\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[H])N=C1[H] [H]OC1=C2C(=NC([H])=C1[H])N(C([H])=C2C1=NC(=NC([H])=C1[H])N([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])N2C1=NC(=C2C([H])([H])[H])C([H])([H])[H])N1N=C([H])N=C1[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NN2C(N([H])C(=C([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1\N=N\C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])C3=C(C([H])=C([H])C(=C3[H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C(C([H])=C(OC3([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1F [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2C(=O)OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(=NC(=C1C#N)C1=C([H])C([H])=NC([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(Br)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C([H])([H])C2=NC([H])=C([H])S2)C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC([H])([H])[H])N=C2N3C(=NC(=C3C(SC([H])([H])[H])=NC2=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C2N=C(N(C2=C1[H])C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(F)F [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C#N)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] CSC1=CC(NC(=O)N(CCC(C2=CC=CC=C2)C2=CC=CC=C2)CCN2CCOCC2)=CC=C1 [H]N1C2=C([H])C(=NN2C(=O)C2=C1C(=O)N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C2([H])[H])C1=C([H])C([H])=C([H])O1 [H]N(\C([H])=C1/C([H])=C([H])C([H])=C(OC([H])([H])[H])C1=O)C1=C([H])\C(=C2/OC3=C(N2[H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C(=O)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=O)C(=O)N([H])[H])C(=C2C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])=C1[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]ON([H])C(=O)C1=C([H])C(=C([H])C(=C1N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(F)=C1OC([H])([H])[H])C1=C(F)C(F)=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] CCN1CCC(C2=CC=CC=C2)=C(C1)C(=O)OCCC1=CC=C(C=C1)[N+]([O-])=O [H]N(C(=O)[C@@](N([H])C(=O)OC([H])([H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(\C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2C1=C([H])C(=C([H])C(=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C(Cl)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C([H])=NN=C2C([H])=C1[H] Cc1cnc(N)nc1-c1c[nH]c(c1)C(=O)NCc1ccc(F)c(Cl)c1 [H]C1=NC([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C2=C(N=C(N=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)N=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=N1 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C(=O)N([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=C(Cl)C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C(F)(F)F [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C(=N/OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])\C([H])([H])[H])C1([H])[H] [H]C([H])([H])N1C2=C(N3C(=N2)N(C([H])([H])C([H])([H])C3([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(F)[C@@]([H])(OC2=C([H])C([H])=C([H])C3=C2N=C(C([H])=C3[H])C2=NN=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C(=O)N(C2=C(OC1([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC([H])([H])[H])N=C2C(=C1[H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C1=NN(N=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1 CC1=CC=C(NC(=O)\C=C\C2=CC=CC=C2)C=C1 [H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2N=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(C([H])=C23)C([H])([H])C([H])([H])[H])C(F)=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[P@](=O)(O[H])[C@]([H])(C([H])([H])[H])[N+]([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C(=O)OC([H])([H])[H] [H]OC1(C#CC2=C(C([H])=C([H])C(C#N)=C2[H])C([H])([H])O[C@]([H])(C2=C([H])N=C([H])N2C([H])([H])[H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N(C(=C1[H])C1=NC(=C2N1C1=NC(OC([H])([H])[H])=C([H])C([H])=C1N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NOC(=C1[H])C([H])([H])OC1=C([H])C2=C(N=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=NN(C2=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]SC1=NN=C(S1)N([H])C(=O)N([H])S(=O)(=O)N([H])C1=NN=C(S[H])S1 COC1=CC(=CC(OC)=C1OC)C(CC(=O)C1=CC=CC(C)=C1)NC1=CC=C(C=C1)N(O)=O [H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])O1)[N+]([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(N3N=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2N([H])C(=C(C2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C(O[H])C([H])=C1[H])C1=C2/N=C(C([H])=C2[H])/C(=C2\N([H])\C(\C([H])=C2[H])=C(/C2=C([H])C([H])=C(N2[H])/C(=C2\N=C\1C([H])=C2[H])C1=C(O[H])C([H])=C([H])C(O[H])=C1[H])C1=C(O[H])C([H])=C([H])C(O[H])=C1[H])/C1=C(O[H])C([H])=C([H])C(O[H])=C1[H] [H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C(F)=C2[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C#CC([H])([H])N(C(=O)[C@@]1(C2=C([H])C([H])=C([H])S2)C([H])([H])[C@@]1([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])[H] [H]O\C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(C([H])=C([H])C([H])=C12)[C@]1([H])OC1([H])[H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N(C1=C([H])C(=NC([H])=N1)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]ON([H])C(=O)[C@@]([H])(O[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C(Br)=C([H])C(=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C1=NC(=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C2=NC([H])=C(C([H])=C12)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=NC(=C([H])C(C#N)=C1[H])C1=C(C#N)C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])OC2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C(C3=C([H])C(OC([H])([H])[H])=C([H])C(=C3N=C12)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])OC2=C(N([H])C1=O)C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C(=C2C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(F)C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N1N=NC(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(C#CC([H])([H])[H])C1=C([H])C([H])=C(OC2=NC([H])=C(Br)C([H])=N2)C([H])=C1[H] [H]C1=C([H])C([H])=C(C(OC2=C(OC(=C([H])C2=O)C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]O\C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C1\C(=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@]1([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H] [H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=NC(=NC([H])=C3C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])N2C([H])([H])[C@@]([H])(N([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C(=C2N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C2=C1Cl)C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N([C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H])S(=O)(=O)C1=C(ON=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])N1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=C2OC([H])([H])C([H])([H])O3)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])=C([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])=C([H])[H] [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])[C@]3([H])C([H])([H])[C@@]3([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C1[H] [H]N1C([H])=C([H])C([H])=C1\C([H])=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])[H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N([H])C1=C(N=C(C(F)=C1[H])C1=C(F)C([H])=C([H])C([H])=C1F)C(=O)C([H])([H])C1=C(C([H])=C([H])N=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C1([H])[H])C(F)(F)F [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=N1 [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C(=C23)C1([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C(C(=O)N([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1N1N=NN=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(OC([H])([H])[H])C([H])=C([H])C2=C(C([H])=C(N=C12)C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C1=C([H])N=C([H])O1 [H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)NC1CCC1 [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C(F)=C([H])C([H])=C3Cl)N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=C([H])C([H])=C2[N+]([O-])=O)N2C(=O)N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])N1C2=NC(OC([H])([H])[H])=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])C([H])([H])[H] [H]N1C2=C(SC3=C2N=C([H])C(=N3)C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N1C2=C(N=C(C3=C([H])C([H])=C(C([H])=C3[H])N3C(=NC4=C3C([H])=C([H])N=C4[H])C([H])([H])[H])C([H])([H])C1=O)N(N=C2C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C(Br)C([H])=C2OC([H])([H])[H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2Cl)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])N(C(=O)C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N1C(=O)C(N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]ON([H])C(=O)C1(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C(=NC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C([H])([H])[H])C1(C2=C([H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C2=C1N=C(O2)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1N=NN=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] C1CN(CCO1)C1=CC(=CC(NC2=NC(NC3=C4C=CNC4=CC=C3)=CC=N2)=C1)N1CCOCC1 [H]OC([H])([H])C(\[H])=C(/[H])[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3=C(C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])=C2OC1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C(SSC2=C(C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H] [H]N([H])C1=C(N=C(N=C1C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])[H])N([H])C1=C(Br)C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C(N2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1(O[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=NN1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C(C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])N3N=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N1C(=O)C([H])([H])OC2=C1C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C([H])O2)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(SC3=C2C([H])=C([H])C(N([H])C(=O)OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C3[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]C1=C([H])N2C(=N1)C([H])([H])C(=NC1=C([H])C(=C(C([H])=C21)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=NC2=C1C([H])=C([H])N=C2[H])C([H])([H])[H] [H]OC(C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)(P(=O)(O[H])O[H])P(=O)(O[H])O[H] [H]ON([H])C(=O)C1=C(Br)C([H])=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(C([H])=C(S1)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(SC2=C(SC3=C2C(=O)N([H])C(=N3)N([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H] [H]OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])SC#N)C1([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl)C([H])([H])N([H])C(=O)C1=C([H])SC([H])=C1[H] [H]N1C([H])([H])C([H])(OC2=C(Cl)C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=N1)C(OC([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC1=C(C([H])=C2N([H])C(=O)C([H])([H])C(=NC2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]2([H])O[H])C2=C(C3=C(N2[H])C(O[H])=C([H])C(O[H])=C3[H])C2=C1C(=O)N(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C2=O [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N2C([H])=C([H])C([H])=C2C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C2=C1N=C([H])N2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(N=NC2=C(C([H])=C1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C2=C([H])C([H])=C([H])C(=C2N=C1Cl)C([H])([H])[H])C(=O)C1=C(Cl)C([H])=C([H])S1 [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3S(=O)(=O)N([H])[H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]O[C@]1(C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1Br)C([H])(N1N=C([H])N=C1[H])C1=C([H])C(Br)=C(O[H])C([H])=C1[H] [H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C(Cl)=C(C([H])=C1[H])[S@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#C[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C2=C1C([H])=C1C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C(=O)C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C12 [H]N([H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C1C(=C2[H])C([H])([H])[C@]2([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])[C@@]2([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H] [H]N(C(=O)C1=C(C2=C(S1)N=C([H])N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C(F)C([H])=C(F)C(=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C(C(Cl)=C3[H])C([H])([H])[H])[C@]([H])(C2([H])[H])C(C(=O)N2C([H])([H])[C@@]3([H])OC([H])([H])[C@]2([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NN(C2=C1[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)C2=C([H])C([H])=C3N=C([H])OC3=C2[H])C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C2N=C(C3=C(C(=O)N(C3=O)C([H])([H])C([H])([H])OC(=O)C([H])([H])[H])C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])N(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)C(C1=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(OC(=O)C(\[H])=C(/[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]2([H])OC(=O)C([H])([H])[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N1C(=O)C2=C(C([H])=C(OC3=C4N=C5N([H])C([H])([H])C([H])([H])C([H])([H])N5C4=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O\N=C1/C(=O)N(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)C2=C(C3=C(O2)C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])[H])C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=NC(C#N)=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])N(C(=O)C4=C(C([H])=C(N=C4C([H])([H])[H])C#N)C([H])([H])[H])C([H])([H])[C@]3([H])C2([H])[H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C2[H])C([H])=C1C(F)(F)F [H]OC1=NC(=NN1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(O[C@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C([H])=C(OC([H])([H])[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N([H])C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C(=NC([H])=C3[H])C2=C1SC([H])=N2 [H]OC([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[C@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])C2=NN([H])N=N2)C([H])([H])[H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[C@@]1(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N([H])N=N1 [H]N(C1=NN(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]C1=C([H])C(=C([H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=NC(=O)C1=C([H])C([H])=C(C(=C1[H])S(=O)(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H] [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@]([H])(C(=O)C1=NN=C(O1)C(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@](N([H])C(=O)[C@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4N=NC([H])=C4[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC1=C2C([H])=C(C(=O)OC2=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C([H])=C1[N+]([O-])=O)C1=C(C([H])=C(C(N([H])C([H])([H])C([H])([H])SC([H])([H])C2=C([H])C([H])=C(O2)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H])[N+]([O-])=O)[N+]([O-])=O [H]N(C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=C(O[C@@]([H])(C([H])([H])[H])C(F)(F)F)C(=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2Cl)C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C(C([H])=C([H])C(C#CC([H])([H])N3C(=O)C([H])([H])C([H])([H])C4=C3C([H])=C([H])C([H])=C4[H])=C2[H])N2C(=NN=C12)C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C(N=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)[C@@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])=C(S2)C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(N=C(N=C12)C#N)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(C([H])=C([H])[H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] CCOC1=CC=C(C=C1)C1=NC(=NC(NC(C)=O)=C1)C1=CC=C(OCC)C=C1 [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=C(N([H])C(=C3[H])C3=C([H])C([H])=C([H])C4=C3C(=O)N([H])C4([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] FC(F)(F)C(=O)C1=CC=C(C=C1)C(=O)N1CCOC2=CC=C(C=C2C1)C1=CC=C2C=NNC2=C1 [H]N([H])C(=NOC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C(=O)N(C([H])([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])[H])N([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=NC(OC([H])([H])[H])=C(N=C1[H])[C@@]([H])(C1=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3OC([H])([H])C(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]12C([H])([H])C([H])([H])[C@@](C3=NC4=C(N3[H])N(C(=O)N(C4=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N2C(=S)S\C(=C(/[H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[H])C2=O)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=C2C(=O)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] COC1=C(CO)C=C(C=C1)C1=CC=C2C(=N1)N=C(N=C2N1CCOC[C@@H]1C)N1CC[C@@H](O)C1 CN1N=C(C=C1C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)=C1)C(F)(F)F [H]N(C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])\C(=C(\C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])(N1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(F)=C(Br)C([H])=C1F [H]N(C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(\[H])=C(/[H])C2=C(N=C([H])C(C#N)=C2N([H])C2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(N=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] CC(C)(C)C1=NN(C(NC(=O)NC2=C3C=CC=CC3=CC=C2)=C1)C1=CC=CC(CN2NC(=O)C(C)(C)C2=O)=C1 [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3N(C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(=N2)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]S\C(=N\C1=C([H])C([H])=C(Br)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)N1[C@]([H])(C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1(OC(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(N([H])C3=C([H])C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C3=C(N=C2C([H])=C1[H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C3[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2([H])C1([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] CC(F)CNS(=O)(=O)C1=CC=C(NC(C)=O)C=C1 [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]N(C(=O)C1=C([H])C(N2C(=O)C3=C(N=C(S3)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O)S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(=NO2)C([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])C([H])([H])[H])C(=O)C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=C(N=N1)C1=C([H])C([H])=C([H])C2=C([H])N=C([H])C([H])=C12)C1=C(F)C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1 [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])=C(C([H])=C(Br)C1=O)C(=O)OC([H])([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H] [H]N(C1=NC([H])=C([H])C2=C1N=C(O2)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=C([H])N=C1[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NC(=N1)C1=C([H])C(=NC(=C1[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(C([H])=C(S2)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])C([H])([H])C(F)(F)F)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])[N+]([O-])=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C(C([H])=C(C#N)C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C(F)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C2OC([H])([H])C(=O)OC([H])([H])[H])C1=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C(N=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]N(C1=C([H])C([H])=NC2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=NC2=C([H])C(Cl)=C([H])C([H])=C12 [H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])S2(=O)=O)C([H])([H])C1([H])[H] [H]OC(=O)C1=C(Cl)C(=C2C(=C1Cl)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H] [H]N(C(=O)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H] [H]OC1=C([H])C2=C(N([H])C(=C2[H])C2=C([H])N=C([H])C(=N2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]2([H])C1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C([H])=C1C([H])=C(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C1=C([H])C2=NON=C2C([H])=C1[H] [H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2=NC([H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]S\C(=N/N=C(\[H])C1=C([H])C([H])=C(O1)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])N([H])[H] [H]SC1=NC(=NO1)C1=C([H])C(=C([H])C([H])=N1)C1=NC(OC([H])([H])C#C[H])=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(=N1)N([H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(C1=C([H])C(Cl)=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]O[C@@]([H])(C1=C([H])C([H])=C([H])O1)[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])=C2C([H])([H])C([H])([H])N3C([H])([H])C4=C([H])C5=C(OC([H])([H])O5)C([H])=C4[C@@]([H])([C@@]23[H])[C@]1([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(S1)C([H])=C(S2)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C1=NC([H])=C([H])N1C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C2=C(C([H])=C([H])C([H])=C2[H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C1([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])(C([H])([H])O[H])C([H])([H])N1C([H])=C(C2=C(N=C([H])N=C12)N([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C(Br)C([H])=C2[H])C([H])([H])N([C@]([H])(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)[C@@]1([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[C@@]1([H])C([H])([H])[C@]([H])(O[C@]2([H])C3=C(O[H])C4=C(C(=O)C5=C([H])C([H])=C([H])C(OC([H])([H])[H])=C5C4=O)C(O[H])=C3C([H])([H])[C@@](O[H])(C(=O)C([H])([H])[H])C2([H])[H])O[C@@]([H])(C([H])([H])[H])[C@@]1([H])O[H] [H]C1=C([H])N(C(=N1)C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C([H])([H])N(C2=O)[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N([H])[C@]([H])(C([H])([H])N([H])C1=NC([H])=C(S1)C1=C([H])C2=C(C([H])=C1[H])C(=O)N([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(N1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C(=NN1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=NC(Cl)=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC([H])([H])C([H])([H])[S@@](=O)C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])S(=O)(=O)C(F)(F)F [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=NN(C1=O)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])N=C(N([H])C([H])([H])[H])C2=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])[H]