[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C(C3=C2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C3([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C([H])C(=C([H])C2=NC(=N1)C([H])([H])OC([H])([H])[H])C1=C(C([H])=C([H])C([H])=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)N=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C1(O2)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])C([H])([H])C([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@](C#N)(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])F)[C@]([H])(C1=C([H])C(\C([H])=C(\[H])I)=C([H])C([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])N1C(=O)N(C(=O)C(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2F)=C1C([H])([H])[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C(F)(F)C(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N(C1=NN=C(O1)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C(S1)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C(Cl)C([H])=C(C([H])=C1Cl)C(F)(F)F [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N([H])C(=O)\C(=C(/C3=C([H])C([H])=C([H])N3[H])C([H])([H])[H])C2=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(C(=NN2C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@@]1(C2=C(C3=C(N2[H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C1(F)F)C(F)(F)F [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)N(C1=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])SC(C1=C([H])C([H])=NC([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON1C2=C3C4=C1C(=O)OC([H])([H])[C@]1([H])N([H])C(=O)C5=C([H])SC(=N5)[C@@]([H])(N([H])C(=O)C5=C([H])SC(=N5)\C(N([H])C(=O)[C@@]([H])(N([H])C(=O)C5=C([H])SC(=N5)C5=C([H])C(O[H])=C(N=C5C5=C([H])SC1=N5)C1=NC(=C([H])S1)C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])=C(/OC([H])([H])[H])C([H])([H])[H])[C@]([H])(OC4([H])[H])[C@]([H])(O[C@]1([H])O[C@@]([H])(C([H])([H])[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])C1([H])[H])C(=O)OC([H])([H])C3=C([H])C([H])=C2[H] [H]N(C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])SC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N1C([H])=NN=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C(F)=C3[H])N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])N(N=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])C1=NC(=O)C([H])([H])S1 [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H])C(=O)C1=NC([H])=C([H])S1 [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C2=C(N(C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[C@]([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C2=N1)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(Br)=C([H])C(Br)=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])N([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(SC([H])=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(OC(F)(F)C(F)(F)O2)C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)[C@]([H])(N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C2=C(C#N)C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=NC2=C(C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C2=C(C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C2=C([H])N=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(Cl)C(=C1[H])C([H])([H])[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=NC([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2C([H])=C([H])C(Cl)=C([H])C2=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[C@]2([H])C1([H])[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(C2=NN([H])C([H])=C2[H])=C(N([H])[H])C(F)=C1[H] [H]N(C(=O)C(\C#N)=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(N([H])C(=O)N2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C2OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3N(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=NC(=NN12)C([H])([H])C([H])([H])C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C(=O)C([H])([H])N1C(=O)SC2=C1C([H])=C([H])C(Cl)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=NC(=NC2=C1C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]([H])(C1=NN=NN1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])[C@]([H])(OC(=O)[C@]1([H])N(C(=O)C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C([H])([H])[H])C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(OC3=C2C([H])=C(C([H])=C3[H])C2=C([H])C([H])=C([H])S2)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(P(=O)(O[H])O[H])P(=O)(O[H])O[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])[C@@]([H])(OC(=S)N(C([H])([H])[H])C([H])([H])[H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@@]2([H])[C@@]2([H])S[C@@]32[H])[C@]1([H])O[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=O)C([H])=C([H])\C1=C(\[H])N([H])N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C2C3=C(N1C1=C([H])C([H])=C(F)C([H])=C1[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(N([H])C(=O)\C2=C2/N([H])C3=C([H])C([H])=C(Br)C([H])=C3C2=O)C([H])=C1[H] [H]N1N=C(N(C1=S)C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])C([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C2=NN=C(O2)C([H])([H])[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C1(C([H])([H])C1([H])[H])C(F)(F)F [H]N(C1([H])C([H])([H])C([H])([H])N(C2=C3N=C(N(C3=NC([H])=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])[H])[C@]([H])(O2)C([H])([H])[H] [H]OC1=C([H])C([H])=C(Cl)C(=C1[H])C1=C(C([H])=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C1=C(O[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)OC([H])([H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] O=C1N(CC2CCCNC2)C2=CC=CC=C2C(C2=CC=CC=C2)=C1C#N [H]N1C(=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(S[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC([H])([H])[C@@]1(ON=C2N1C([H])([H])C([H])([H])C([H])([H])\C2=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1F)C1=NC(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(S1)C([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N(C([H])=N3)C([H])([H])C2=C([H])C([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C(N([H])C2=C([H])C3=C(C(=O)N([H])C([H])=C3[H])C(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2OC([H])=C(C2=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(Cl)=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(\C([H])=C(/[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12 [H]C1=C([H])C(=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1OC([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N([H])C1=NC2=C(C(=C([H])O2)C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(F)=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F [H]N(C(=O)C1=C([H])C([H])=C(\N=C(/N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)N2C([H])([H])C([H])([H])[C@@]([H])(C3=C([H])N([H])N=C3[H])C2([H])[H])C([H])([H])C1([H])[H] OC1=CC=C(C=C1)C1=NC2=CC=CC=C2N1CC1=CC=C(OCCN2CCCCC2)C=C1 [H]C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C(=O)C1=C2N([H])C(=O)N(C2=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]\C(=C(/C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)OC1=C([H])C([H])=C(OC2=NC([H])=C(Cl)C([H])=C2Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(=C3N=C(N([H])C3=C2[H])C2=C(N([H])C([H])([H])[C@@]([H])(O[H])C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])=C([H])N([H])C2=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])OC2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N1N=C(C([H])=C1C1=C([H])N([H])C(=O)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=NC([H])=C([H])C([H])=C3C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C(SC3=C([H])C(Cl)=C([H])C([H])=C3[H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N1[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=C([H])N(C([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]1(O[H])C([H])([H])[C@@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])[C@]([H])(O[H])[C@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])C1([H])[H] [H]C1=C(F)C(C#N)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=NC2=C1C([H])=C(C([H])=C2Br)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C3=NC(=C([H])C(=N3)C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C#N)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1(C2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CCN(CC)C1=CC=C(CN(C2=CC=C(Cl)C=C2)S(=O)(=O)C2=CC=C(C)C=C2)C=C1 [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1)C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]C1=C(C(C(=O)C2=NC(=NC(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])C([H])([H])C3([H])[H])=C2C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C(O[H])C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C(O[H])C(=C1[H])C(=O)N([H])C([H])([H])[H] C[C@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(C)(C)O [H]N(C(=O)OC([H])([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C(\[H])=C(/[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(F)(F)F [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]1([H])N(C3=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C3C([H])([H])N1C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]ON([H])C(=O)[C@@](O[H])(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])[C@@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]O[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C1([H])[H])C([H])([H])[C@@](C3([H])[H])(C2([H])[H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] ClC1=CC(=CC=C1)C1=CNC(=N1)[C@@H]1CC2=CC=CC=[C]2=CN1 [H]N(C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2C([H])=C([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C(N=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])N=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] CC1=CC=C(C=C1C(=O)NCCNC1=CC=CC=C1)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C [H]N(C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=C(N([H])C([H])=N3)C([H])([H])[H])C([H])=C12 [H]OC([H])([H])C([H])([H])N([H])C([H])([H])[C@]1(O[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3OC([H])([H])[H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(SC2=NC([H])=NC(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C12)C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NN2C([H])=C([H])C(Cl)=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C(=NC2=C([H])C([H])=NN12)C([H])([H])[H] [H]C(=O)C1=C(C2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[N+]([O-])=O)C([H])([H])N1C([H])=NC([H])=C1[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C2=C(O1)C([H])=C([H])C(=C2[H])S(=O)(=O)N1C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])N2C(=NC(=C2C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C([H])([H])C(=O)OC([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]C1=C([H])N2C(=C1[H])[C@]([H])(N(C(=O)C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C(N([H])C([H])=O)C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC(=O)C([H])([H])[H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=NC2=C(Br)C([H])=NN12)C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])N([H])C(=O)C1=NO[C@]2(C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C1=NC([H])([H])C([H])([H])C([H])([H])N1[H])C([H])([H])C2([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]SC1=C(C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC(=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C(=O)N(C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(ON=C2C2=C(O[H])C([H])=C(O[H])C(=C2[H])C([H])([H])[H])=C1[H] CN1CCN(CC1)C(=O)C1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=CC=C2)C=C1 [H]C1=C([H])C([H])=C(S1)C([H])([H])OC(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C([H])C2=C([H])C([H])=C(F)C([H])=C12 [H]N(C(=NC1([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]