[H]C1=C([H])C(Cl)=C2N=C(N(C(=O)C2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(Br)=C2C([H])=C([H])C([H])=C([H])C2=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(N=C12)C#CC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H])N([H])OC([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)OC([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])C(F)=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
CN1C=CC(=N1)C(=O)NC1=CC=C(F)C(=C1)[C@@]1(C)N=C(N)OCC1(F)F
[H]O[C@@](C(=O)N([H])[C@@]([H])(C1=C(Cl)C([H])=C(C([H])=N1)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C(F)(F)F
[H]N(C1=C([H])C([H])=C2N=NN(C2=N1)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H])[C@@]1([H])C([H])([H])[C@@]2(C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NC([H])=C([H])S1
[H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])N([H])[H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]N1C(=O)N(C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2N([H])C([H])=NC2=C1[H]
[H]N1C(=O)[C@]([H])(N(C(=O)[C@@]1([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])OC(=N1)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(C#N)=C(SC2=C([H])C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C2N(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=C(C2=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(N(C(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=NN([H])N=N1
[H]C1=C([H])C(=C([H])C([H])=C1SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O\C(\C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])=C1\C(=O)[C@@]2(C(=O)[C@@](O[H])(C([H])([H])[H])[C@@]1([H])[C@@]([H])([C@@]2([H])C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])[C@@]1(OC(=O)C(=C1O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C(N4C([H])=C([H])C(=C([H])C4=N3)C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(C#N)(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]OC1=C(Cl)C([H])=C(C([H])=C1[H])C1=C(N=C(N=N1)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=O)N([H])C1=O)[N+]([O-])=O
[H]C1=C2C(=O)OC([H])([H])C([H])([H])C2=C([H])C2=C1[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]([H])(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C(OC2=NC([H])=C(S2)C#C[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C(=NC([H])=N1)C#CC1=C([H])N=C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]C([H])=C(C([H])([H])N([H])C(=O)C1=C([H])C([H])=C2N(C([H])=C(C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(F)(F)F
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1([H])[H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(F)(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=NN(C([H])=C1[H])C1=NC2=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]ON(C([H])([H])C([H])([H])N([H])[H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[N+]([O-])=O
[H]ON([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H]
[H]\C(=C1\SC(=S)N(C1=O)C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(N([H])C([H])([H])C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2/N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C2=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(\N=C(\N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C(C#CC([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])=N1
[H]N1C2=C(C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C2=C1C1=C(C3=C2C([H])([H])N([H])C3=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)N(C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=NC([H])=C([H])S1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N([H])[C@]([H])(SC1([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N/OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])\C1=C([H])N=C([H])C([H])=C1[H]
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[H]C1=NC([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C(F)C(F)=C12)C([H])([H])N1C2=NC([H])=C([H])C(=C2N=C1C1([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
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[H]N1C(SC([H])([H])C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C([H])=C([H])C([H])=C2[H]
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[H]N(C1=C(N=C2N=C([H])C([H])=C([H])N12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(C#N)=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CN1CCN(CC1)C1CC2=C(SC3=C1C=C(C=C3)C#N)C=CC=C2
[H]OC1=C([H])C(=C([H])C2=C1[C@@]1([H])C([H])([H])N(C([H])([H])C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(C(=O)N(C([H])([H])[H])C([H])([H])[H])=C(SSC1=C(C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3N1C([H])([H])[H])N2C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1(C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]O[P@@](=O)(C([H])([H])[C@]([H])(C(=O)N(N([H])[H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=NC(C2=NN=C(O2)C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O\N=C1/C(=O)N(C2=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H]
[H]C([H])=C([H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C(SC([H])([H])[H])=C2C2=C1C1=C(N([H])C(C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H]
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[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]C1=C(N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(OC3=NC([H])=NC(=C3[H])C3=C(N([H])[H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2N([H])C1=O
[H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=[N+]2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H]
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[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])(OS(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
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[H]\C(=C(\[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])C1=O
[H]N([C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
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[H]C1=C([H])C(=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])SC1=C(C#N)C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
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[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C2=C(N=C(N([H])C([H])([H])[H])C3=C2N(C([H])=N3)C([H])([H])[H])N1[H]
[H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N(N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])C1=NC(=O)C([H])([H])S1
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[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])[H])C2([H])[H])=C2C([H])=NN(C2=N1)C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])S1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])N2N=C([H])C(C#N)=C(N([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1C([H])([H])[H]
[H]N(\C(=N/S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])N1N=C([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=NC(=C(C2=C([H])C(=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C1=C([H])C([H])=C(F)N=C1F)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C(OC(=O)C([H])([H])[H])C(OC(=O)C([H])([H])[H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])OC([H])([H])C1=C2N(N=C([H])N=C2N([H])C2=C([H])C3=C(C([H])=C2[H])N(N=C3[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]ON(C(=O)N([H])[H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C([H])C([H])=C(C#CC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C1=O
[H]C1=C2C(=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C1=NN(C(=C1C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(N([H])\N=C(\C(=O)OC([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S1
[H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])C([H])=C(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])N(C([H])=N2)C([H])([H])C(\[H])=C1/C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C1C([H])=C(C([H])=C2[H])C(=O)O[H]
[H]C1=C([H])C(=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])O[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=NC2=C(SC([H])=C2[H])C(=N1)C(=O)C1=C([H])C([H])=C(S1)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C(O[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(C#N)=C1[H]
CC1=C(SC(=C1)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
[H]C1=C([H])C([H])=C2C(SN=C2C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(C([H])([H])C([H])([H])C([H])([H])N([H])[H])(C([H])([H])C([H])([H])C([H])([H])N([H])[H])C2([H])[H]
CO[C@H](C[C@H](CCN(C)CC1=CC=C(C=C1)C1=CC=C(F)C(C)=C1)C(=O)NO)C1=CC=C(F)C=C1
[H]C1=C([H])C([H])=C2C(=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C1=NC2=C([H])C([H])=C(Br)C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)[C@@]([H])(C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]ON(C([H])=O)[C@]([H])(C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])O[H])C([H])([H])O[H]
[H]N(C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F
CN1C(=O)C(CC2=CC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12
[H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N(C(=C1[H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=S)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]1([H])ON=C(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
CCCC1=NN=C(O1)C1=CC=C(C=C1)C#C[C@]1(CN2CC3=C(C=C(OC)C=C3)C2=O)CC(=O)NC1=O
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(C2=NC([H])=NC(N([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])O[H]
[H]N(C(=O)C1=NN(C(=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C2=C(N=C(N2[H])C2=C(F)C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=NC([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]O\C(=N\C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C(=O)O\C(=C(\[H])I)C([H])([H])C1([H])[H]
ClC1=CC=C(C(Cl)=C1)S(=O)(=O)NC1=CC=C(OC2=CC3=CC=CC=C3C=C2)C(Cl)=C1
[H]OC(=O)[C@]12C([H])([H])C([H])([H])C(=C([H])[H])[C@]([H])(C([H])([H])[H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@](C([H])([H])[H])(C([H])([H])O[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])[H])C([H])([H])C1=C2SC([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C2=NN=C(O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H]
CCCCOC1=C(CNC(=O)C2=C(F)C=C(C=C2)C(F)(F)F)C=C(C=C1)C1=C(C)C(=CN=C1C)C(O)=O