[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C(=C([H])C([H])=C3F)C(F)(F)F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]OC(=O)C([H])([H])N([H])C(=O)C1=C2N=C([H])N([H])C2=C([H])C([H])=N1 [H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C(=O)N([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H] [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]O\N=C(/[H])C1=C(C(=C([H])N1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C(=N1)C1=C(N=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C([H])=N1 [H]OC(=O)C1=C(Cl)C([H])=C([H])C(N([H])\N=C2\C3=C([H])C([H])=C([H])C([H])=C3O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1\C([H])=C(/[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])O\N=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])N([H])C(=O)C([H])([H])[H])C([H])([H])SSSSC([H])([H])[C@]2([H])N([H])C(=O)[C@@]3([H])N([H])C(=O)[C@@]4([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])O[H])C([H])([H])SSSSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C2=O)C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])SSSSC3([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSSSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C1=NC2=C(S1)C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C(=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1C([H])=C([H])C([H])=C2C1=NC2=C(OC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C(=C(SC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])N2[H])C([H])([H])C([H])([H])[H])C(=N1)N([H])[H] [H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])[C@]([H])(C([H])([H])Cl)C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(F)C([H])=C2[H] [H]N(C(=O)[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])N=C2C(F)=C(F)C(F)=C(F)C2=N1 [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(C([H])=C(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])N(C1=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(\N=C(\[H])C1=C(C([H])=C([H])S1)C([H])([H])[H])C1=C(Cl)C(=O)N([H])N=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N1[C@@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(=C([H])C([H])=C3[H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]N([H])C1=NC2=C(C([H])=C(S2)C(=O)N([H])C([H])([H])C([H])([H])[H])C(=N1)C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(Cl)C([H])=C1Cl [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C2=C3N(C([H])=C2C([H])([H])C([H])([H])[H])C([H])([H])S(=O)(=O)N(C3=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(S1)C(=O)C(F)(F)F)[C@@]([H])(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(\C([H])=C1/[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H] [H]OC(=O)[C@@]([H])(O[H])C([H])([H])N(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C2=O O=C1CCCN1CCCNCC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1 [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C(C#N)C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]OC1=C2O[C@@]3([H])[C@]([H])(OC([H])([H])[C@]4([H])OC(=O)C(=C([H])[H])C4([H])[H])C([H])([H])C([H])([H])[C@@]4(OC(=O)C([H])([H])[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=NN([H])C2=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]N([H])N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])=NC2=C(C([H])=C([H])S2)C1=O [H]N=C(N([H])[H])C1=C([H])C([H])=C(\C([H])=C2\C(=O)\C(=C(/[H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N\C([H])([H])[H])\N([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])(C([H])([H])C2([H])[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1N=NN=C1[H] [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C([H])([H])C([H])=C([H])C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C([H])N=C12)N([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N([C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])[C@]([H])(S[H])C(\[H])=C(/[H])\C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(SC2=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C2C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Br)=C1[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[N+]([O-])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(OC([H])(F)F)C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(S1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12 [H]C1=C([H])C2=C(C(=NC2([H])[H])C2=C([H])C(=NC([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=N1 [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1[C@@]2([H])C(C(=O)N(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H] [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])\N=C(/N([H])[H])[N+]([O-])=O [H]C1=C(N=NN1C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1=NN([H])C(=O)C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1C(=NC2=C1C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(\C(=N/OC(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C2C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C2N1[C@]([H])(SC2([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C2N(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C(=C([H])N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(C([H])([H])C1=NC(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=N1)[C@@](OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=O)N(C(=O)C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] COC1=CC=C(C(=O)N[C@@H]2C[C@@H](N(C2)S(=O)(=O)C2=CC=C(Cl)C(Cl)=C2)C(=O)NO)C(OC)=C1 [H]N(C1=NN=C(O1)C1=C([H])C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] CN(C)CC(=O)NC(C1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 [H]N(C(=O)N1C2=C(OC([H])([H])C1([H])[H])C([H])=C(OC1=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C13)C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)C(=O)C1=NC(OC([H])([H])[H])=NC2=C1SC([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(SC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H] [H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C2([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(F)C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C#N)C(OC3=C([H])C([H])=C(C(=C3[H])C([H])([H])N3C(=O)C([H])([H])[N@@](C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(C2=C([H])C(OC([H])([H])[C@@]3([H])N(C(=O)C([H])([H])[H])C4=C(C([H])=C([H])C([H])=C4[H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C2=N1)C(C#N)(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(OC([H])([H])[H])=C([H])C([H])=C1Cl)C1=C2C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C([H])C2=NC([H])=N1 [H]N(C(=O)C1=C([H])N2C(=NC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C(F)(F)F [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OS(=O)(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])N(N=C2C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OP(=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]2([H])O[C@@]([H])(O[C@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C(F)=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1 [H]N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1(N([H])C(=O)C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=NC([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(Cl)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N=C(SC([H])([H])C([H])([H])[H])N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1N=C([H])C(Cl)=C(Cl)C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1 [H]C1=C([H])C([H])=C2C3=NN=C(C([H])=C3C(=O)C2=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=NC(C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])N=C2C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)N1[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1(OC(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C(OP([O-])(=O)OC([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])OC2=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]OC(=O)[C@@]1([H])OC2=C([H])C([H])=C(OC([H])([H])C3=NC(=C(S3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C2C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2=C(C3=C(O2)N=C(N=C3N([H])[H])N([H])[H])C([H])([H])C1([H])[H])C(=O)O[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=O)N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]C1=NN(C2=NC([H])=NC(OC3([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]O[C@]([H])(C(\[H])=C(/[H])C1=C(SC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C(\C([H])=C(/[H])C3=C([H])N=C([H])C(C#N)=C3N([H])C3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C1([H])[H] [H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C(=NS(=O)(=O)C1=C([H])C([H])=C(\N=N\C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])N([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=O)N1C([H])([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]C1=C([H])C(F)=C([H])C(=C1[H])[C@@]1([H])C2=C([H])C([H])=C(Cl)C([H])=C2[C@@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C1([H])[H] [H]N([H])C1=C2N([H])C(=O)N(C2=C([H])C(=N1)C1=NC([H])=C([H])O1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])=C([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C(C([H])=C3C(=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])N2C3=C(C([H])=C([H])C(F)=C3[H])C([H])([H])C2([H])[H])S1(=O)=O [H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=NN(N=C1C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@]2([H])N([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=N\C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])OC(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(OC([H])([H])[H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])[N+]([O-])=C4[H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(S1)C1(C([H])([H])C1([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C3=C(C(=NN3C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=NN([H])C([H])=C1Br [H]C1=NN(C(C(=O)N2C3=C([H])C([H])=C(N=C3[C@@]([H])(N(C3=NN(N=N3)C([H])([H])[H])C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[H])C(F)(F)F)=C1C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C([H])=NC([H])=C12)C1=C([H])C([H])=C([H])N=C1[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(F)C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C(F)=C2F)C1([H])[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(C2=NC(=C3N2C2=C([H])C(OC([H])([H])C4([H])C([H])([H])C4([H])[H])=C([H])C(F)=C2N=C3C([H])([H])[H])C([H])([H])[H])=C(C([H])=N1)C([H])([H])[H] [H]N(C(=O)C(F)(F)C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(OC1=C(C#N)C(N([H])[H])=C([H])C(=N1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(F)C(F)=C1C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C1=C([H])C(N([H])C(=O)C2=C(N=C(N2[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2C([H])([H])[C@@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C([H])([H])C1=O [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C([O-])=O)C([H])([H])C1=NC2=C([H])C(=C([H])C([H])=C2C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NN=C(S1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(I)=C([H])C(=C1[H])C(=O)OC1=C([H])C(C#CC2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])=NC3=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Br)OC(=C1[H])C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=O)O1 [H]O[C@@]1([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])=C(N([H])C(=O)\C(=C(/[H])\C(\[H])=C([H])/[C@]([H])(OC([H])([H])[H])[C@@]([H])(OC(=O)N([H])[H])\C(=C([H])\[C@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=O OC(=O)[C@H]1CC[C@@H](CC1)OC[C@@H]1C[C@H](F)CN1C(=O)CC1=CC=C(NC2=NC3=C(O2)C(F)=CC=C3)C(Cl)=C1 [H]N(C1=C([H])C(SC([H])([H])C([H])([H])[H])=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N1C([H])=C([H])C2=C3N(C([H])=NC3=C([H])N=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=NC(=NC([H])=C1Cl)S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=NN=C(S1)C([H])([H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])=NC3=C(C4=C(S3)C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C2=O)C([H])([H])C1([H])[H] [H]OC1=C2C([H])=C(C([H])=NC2=NC(=C1[H])C1=C([H])C([H])=C(S1)C([H])([H])[H])C([H])([H])[H] [H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C1(N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C1([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]N([H])C1=C(N=C(N=C1N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C#N)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=C(C#N)C3=NN=C(N3C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C(C2=C(C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])SC([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2([H])[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]2([H])C([H])([H])C(=O)O[C@]2([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C(C(=O)C([H])([H])[H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2C([H])=C([H])OC2=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2N([H])C(=O)C([H])([H])N(C2=NC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C(N=C2C([H])=C(C([H])=C([H])N12)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NN(C(=O)C2=C([H])SC([H])=N2)C2=C1C([H])=C(Cl)C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC([H])([H])C([H])([H])C([H])([H])N2[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC([H])([H])[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(SC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]2([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])N=C2[H])C2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(SC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=NN=C3N2C2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])OC3([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC1=C([H])C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C2=C1[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])O[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])SC([H])([H])C2([H])[H])C1([H])[H] [H]N(C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=N[C@]([H])(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])S2)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C(=O)N([H])C(=O)C2=C1C([H])([H])C([H])([H])SC2([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])C([H])([H])C1(C2=C([H])C3=C(C([H])=C2C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])/C([H])([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]2([H])OC(=O)[C@@]3([H])N(C(=O)C(=O)[C@]4(O[H])O[C@@]([H])(C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])[H])C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])[H])\C(=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C([H])\[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)[C@]([H])(OC([H])([H])[H])[C@]([H])(O[H])\C(=C([H])\[C@]([H])(C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])[H] [H]N([H])C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])C(=O)C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=C([H])C([H])=C(C1=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C(\[H])=C1\C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C(Cl)C([H])=C(C([H])=C2[H])N2N=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1(F)F [H]C1=NC([H])=C(S1)C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H] [H]C1=C([H])C2=NC([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(SC(=N3)C([H])([H])[H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C#N)C2=C(S1)C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C(=NO1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(OC([H])([H])[H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C(Br)=C(N([H])C(=O)C([H])([H])[N+]2=C(C([H])=C(C([H])=C2C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])N=C1C([H])([H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C(=O)N1N=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(N=N1)N([H])C1=C([H])C([H])=C(OC(F)(F)Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O [H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC1=C2N=C([H])C(C(=O)C([H])([H])C([H])([H])[H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C2=C([H])C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(\C([H])=C2\C(=O)\C(=C(/[H])C3=C([H])C(OC([H])([H])C([H])([H])[H])=C(O[H])C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1Cl [H]N([H])C1=NC([H])([H])C([H])([H])[C@]([H])(C1([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C(I)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N(C1=C([H])C(OC2=C([H])C(=C(F)C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)C([H])(F)F)=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])[C@@]2([H])[C@@]3([H])[C@@](OC(=O)C([H])([H])[H])([C@]([H])(OC(=O)[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])[C@]2([H])C([H])=C(C(=O)[C@]2(O[H])C1([H])[H])C([H])([H])[H])C3(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]N(C([H])([H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])N=C(C([H])=C1[H])C(F)(F)F)C1=C(Cl)C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N1C(=S)N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])[C@@](N([H])[H])(C(=O)O[H])C([H])([H])C1([H])C2=C(OC3=C1C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2[H] [H]OC1(C([H])([H])N2C(=O)N(C3=C(C([H])=C(S3)C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C2=NOC(=O)N2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=NC2=C(Br)C([H])=NN12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1N=C([H])C([H])=C1[H] [H]ON(C(=O)N([H])[H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]\C(=C1/C2=C([H])C([H])=C([H])C(=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C(OC([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(N(C3=NN(N=N3)C([H])([H])[H])C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C2=NC(=C1[H])C(F)(F)F [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=NC2=C1C([H])=NN2C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N=C(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(C2=NC(=C3N2C2=C([H])C(F)=C([H])C([H])=C2N=C3C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C2[H])C1=NC2=C(C#N)C([H])=NN2C(N([H])C2([H])C([H])([H])C2([H])[H])=C1[H] [H]N(C(=O)C([H])([H])SC1=NC(=O)C(=NN1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N1C(=C3C([H])=C4C5=[N+](C6=C(C([H])=C(C([H])=C6[H])S([O-])(=O)=O)C5(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4([H])O[C@@]3([H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)(C(F)(F)F)C(F)(F)F [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)N([H])C2=C(Cl)C([H])=C([H])C3=C2OC([H])([H])O3)=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\[C@]([H])(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C1=C([H])N=C2N=C(SC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN=NN1[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])S1)[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N=C(S1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N2C(=O)[C@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C3(C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(C([H])=C1Br)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H]OC1=C(O[H])N=C2C(=N1)C([H])=C(C#N)C([H])=C2[N+]([O-])=O [H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])O3)C([H])=C12 [H]C1=C([H])C(=C([H])C(OC(F)(F)F)=C1[H])S(=O)(=O)N(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C(F)=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] COC1=CC=C(C=C1)C(N1CCOCC1)C1=C(O)C2=NC=CC=C2C=C1 [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])C3=C2C(=O)C2=C(N([H])N=C32)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C([H])C(F)=C([H])C([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] Clc1cc(Cl)cc(c1)-c1cn[nH]c1-c1c[nH]c(c1)C(=O)N1CCOCC1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C(C#N)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C(=C([H])C3=C2C(=C1[H])C(=O)N(C3=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] CC1=CC(NC(=O)NCCCC[C@@H](NC2=CC(C)=C(F)C(C)=C2)C(=O)NO)=CC=C1F [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C(=O)[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])=C([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C(=O)N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]C1=C([H])N(C(=O)C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC[C@@H](NC(=O)C1=CC=NC2=CC=CC=C12)C(=O)N1CCC[C@H]1B(O)O [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C(C(=NC(=N1)C1([H])C([H])([H])C1([H])[H])N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]N1C(=O)C2=C([H])C([H])=C3C4=C2C2=C(C([H])=C([H])C([H])=C12)C([H])([H])[C@@]4([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3S2(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(O3)C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C2=C(N=N1)C([H])=C(Cl)C([H])=C2[H] [H]N(C(=O)C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] CC[C@H](CO)NC1=NC(SCC2=CC=CC=C2)=NC2=C1SC(=O)N2 [H]O[C@](C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2C(F)(F)F)(C([H])([H])C(C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N1C2=NC([H])=C(Cl)N(C2=O)C([H])([H])C(=O)N([H])C([H])([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C(Cl)=C2[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])=C([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(N1C([H])([H])[H])C(=N[H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] COC1=C(F)C2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC4=C(NC(=O)N(C)C4)C=C3)C2=O)C=C1 [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C(=N1)C1=C([H])C([H])=C([H])O1 [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C([H])C([H])=C12 [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N1C([H])=C(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N2C(=C([H])C([H])=C2C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C#CC([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=NC([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC1=C2O[C@@]3([H])C(=C([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)[C@]1([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])[C@@]1([H])OC(=O)C([H])([H])[H] [H]C1=C(C(=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(\C([H])=C(/[H])C2=C(C([H])=C([H])N=C2[H])C2(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C(F)N=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C(C([H])=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@]12C([H])([H])[H] [H]OC1=C([H])C(N([H])C2=C3C([H])=C([H])C(=C([H])C3=NC([H])=C2[H])C2=C([H])SC(=N2)C([H])=O)=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=O)N2C(=C1[H])[C@@]1([H])C([H])([H])N(Br)C([H])([H])[C@]([H])(C2([H])[H])C1([H])[H] COC1=CC2=C(C=NN2C2=NC3=C(NC=C3C(=O)NC(C)(C)C)N=C2)C=C1 [H]N1C([H])=C(C2=C([H])C(Br)=C([H])C([H])=C12)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N1C(=O)C(C2=C([H])OC3=C([H])C([H])=C([H])C([H])=C23)=C(C1=O)C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN([H])C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]C1=NC(=NC([H])=C1F)N1C([H])([H])C([H])([H])N2C([H])([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2C(=N1)N([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(I)N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(=O)[C@@]([H])(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])SC2=NC3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1N([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]2([H])C1=NN(N=N1)C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(N([H])C(=O)C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])=C2[H])C([H])=C1[H] [H]OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(Br)C([H])=C1\C([H])=C1/SC(=O)N([H])C1=O [H]C1=NC2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C4=C([H])C([H])=C(C#N)C([H])=C4C([H])([H])C([H])([H])[C@]23[H])C1([H])[H] [H]N1C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N(C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C12 [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=NSN=C12)C(\C([O-])=O)=C(\C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])N(C(=O)N([H])[C@]2([H])N=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C(C([H])=C([H])C([H])=C3[H])N(C2=O)C([H])([H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C2N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(N(C3=NN(N=N3)C([H])([H])[H])C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C2=N1 [H]C1=C(N=C2N=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C(=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(=O)N2C([H])([H])[C@]3(C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C(Cl)=C1[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C(F)=C1F [H]N([H])C1=C(C(=NC([H])=N1)C#CC1=C([H])N=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=C1C#N)C([H])([H])O[C@@]([H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=NN(C2=C1C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C2([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(Cl)=C3C(=O)N(C([H])=C([H])C3=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=N1)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=NN=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1[H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C(=O)C([H])=C([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]O[C@@]([H])(C1=C([H])C(=C([H])S1)C(=O)N([H])C1=C([H])C(C#CC2=C([H])C(C(=O)N([H])[H])=C(S2)N([H])C(=O)N([H])[H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NN3C3([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C3([H])[H])C(=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] COC1=CC=C(C(C)=C1)S(=O)(=O)N(C)CCOCC(=O)N(C)CC1=CC=C(C=C1)C1=NCCN1 [H]\C(C(=O)OC([H])([H])[H])=C1/C([H])([H])N(C([H])([H])[C@]2([H])N(C(=O)C([H])([H])C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([C@@]([H])(\N=N\C2=C(F)C([H])=C(F)C([H])=C2[H])C1=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])N=C3C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])N([H])C1=O [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC(=O)N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(O[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])C3=C(C(N([H])C(=O)C4([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C1=C([H])C(=NC2=C(C(=O)N([H])[H])C(=NN12)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N2C(=NC(=C(C(=O)OC([H])([H])[H])[C@]2([H])C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])SC1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C(=C1C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)[C@]([H])(OC([H])([H])C([H])([H])C1=C2S[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=NC(=C(N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C(=C2O[C@@]([H])(SC2=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)O[C@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C(S1)C([H])([H])N(C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=NC2(N([H])C3=C([H])C([H])=C([H])C(F)=C13)C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C2([H])[H] [H][C@]12CC3=C(C(OC)=CC=C3)[C@@]3(CCN1CC=C)CC(=O)CC[C@@]23[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]12[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(=O)N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2C(=C1[H])C(=NC2([H])[H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C1=C(Br)C([H])=NC(=N1)N([H])C1=C([H])C(=C(C([H])=C1[H])[S@](=O)(=NC(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C([H])=C([H])C(=NC2=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C(=N1)C1=NC([H])=C([H])S1 [H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(F)C(N([H])C([H])([H])C(F)(F)C2=C([H])C([H])=C(Cl)C([H])=N2)=C([H])C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)C(=O)N([H])C1=C(C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])(O[H])O[H] COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(CCC(=O)NS(C)(=O)=O)=C(C)C2=C1 [H]OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2(N([H])C(=O)C3=C([H])C4=C(S3)C([H])=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C(=N1)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C#CC2=C([H])C([H])=C3C(=C2[H])C(=C([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])S2)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C(=O)N([H])N([H])C(=O)C1=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2N=C([H])N=C3N([H])[H])C2=C(OC([H])([H])[H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1 [H]O[C@@]1([H])C([H])([H])N(C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1N=C([H])N=C1[H] CCCCCCCCS(=O)(=O)NC1=CC(SC2=NC=NN2)=C(O)C2=CC=CC=C12 [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(N3C([H])([H])C([H])([H])N(C(=O)C4=C([H])C(=C([H])C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])=C(C([H])=C2C(F)(F)F)[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])OC2=C3C(N([H])C(=O)C3([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C1=C([H])C2=C(OC1=O)C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] NC(=O)CN1C=CC(=O)C(=C1)S(N)(=O)=O [H]C1=C(I)C(=O)C([H])([H])[C@@]2([H])N1C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]OC([H])([H])C1=C([H])C(N(C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C(=C([H])C(=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(N=C([H])C([H])=C2N1[H])C1=C([H])C(Br)=C(Br)N1[H] [H]N([C@@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(S3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C(=C([H])C([H])=C1[H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(Cl)=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC3=C2C([H])=C([H])C(=C3[H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(S1)C(=N[H])N([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] OC(=O)C1=C2OC3=C(C=C(C=C3)C3=CSC(=N3)C3=CC=C(C=C3)[N+]([O-])=O)C2=CC=C1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2N(C(=C([H])C2=C1[H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])N(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])[C@]1([H])C2=NC([H])=C(Br)C([H])=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N(C(=C2[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]([H])(N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])\C(=C(/[H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])\C(=C(/[H])\C(\[H])=C3\C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])\C([H])([H])[H] COC1=CC=C(NC2=C(C(C)=NN2C2=C(C)C=CC=C2)C2=CC(F)=C(F)C=C2)C(=C1)C(O)=O [H]N(C1=NC([H])=C([H])C2=C1N=C(O2)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=C([H])N=C1[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C(=O)\C1=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C([H])C(F)=C(C(F)=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])[H] [H]C([H])=C([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])[C@@]([H])(O[C@@]2([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=NN1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=N1)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C(OC2=C([H])C([H])=C(Br)C([H])=C2Br)C(Br)=C(Br)C(Br)=C1[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N=C(C([H])=C2C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])N=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(N=C12)C#CC1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H] [H]OC([H])([H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])C([H])([H])N(C1=C([H])C2=C(C([H])=N1)C(=NC([H])=N2)N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])C([H])=C1[N+]([O-])=O [H]C1=C(N=C2C(=C1[H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C1=NN(N=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C2N1[C@]([H])(C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(O[H])=C1C1=C([H])C(OC2=C([H])C(N([H])C(=O)C([H])([H])Cl)=C([H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C2([H])[H] [H]N(C1=NC([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC2([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C2C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H] C(N1CCOCC1)C1=COC2=CC(OC3=NC4=CC=CC=C4S3)=CC=C12 [H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C2=C3C(=NC4=C([H])C([H])=C([H])C([H])=C24)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=O)C3=C(OC2=C1O[H])C([H])=C([H])C([H])=C3[H] [H]OC1=C(C([H])=C([H])C([H])=C1N([H])C1=C(N([H])[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=NN(\C(S1)=N\C(=O)C1=C(F)C(F)=C([H])C(F)=C1F)C([H])([H])[H] [H]OC(=O)C([H])([H])N(C(=O)C1=C([H])C([H])=C2N(C(=O)[C@@]([H])(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])OC2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NN2[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C(Cl)=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C2([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=NC3=C(N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C(=O)N(C2=C3C([H])=C([H])C([H])=C2C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])S[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])O3)C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N2C(OC([H])([H])[C@@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F CC1=C(Cl)C(=NN1CC(=O)N1CCN(CC1)C1=CC=CC(C)=C1)C(F)(F)F [H]C1=C(C([H])=C(Br)C(=C1[H])N(C1=NC(=C([H])C(=N1)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H] [H]N(C(=O)[C@]([H])(N1C(=NC2=C([H])C([H])=C(C([H])=C12)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C(N=C12)C1=NN=C2C([H])=C([H])C([H])=C([H])N12 [H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C([H])SC2=NC([H])=N1 [H]OC(=O)C1=C(C(=NC2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H] [H]N1C(=O)[C@]2(C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(Cl)C([H])=C(OC([H])([H])[H])C(=C1[H])C1=NC(=NN1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])N(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C([H])([H])[C@@]11C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])N=N1 [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]([H])(SC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C2=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C2=C3C([H])=C(N=C([H])C3=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N([H])C2=O)C1=C([H])N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NO[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(\[H])=C1\C(=O)N([H])C2=C([H])C([H])=C([H])C(Cl)=C12 [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2=C(N=C(N2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N(C1=NC(=C(S1)C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O)[C@@]1([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C([H])N2[H] [H]N1N(C(=O)\C(=C(\[H])C2=C([H])C([H])=C(I)C([H])=C2[H])C1=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@]([H])(N(C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N2C(=NC(=C2C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(F)(F)F COC(COC1=CC=C(CC[C@](C)(O)[C@H]2C[C@@]34C=C[C@]2(OC)[C@@H]2OC5=C(OC)C=CC6=C5C32CCN(C)C4C6)C=C1)C[Hg]Br [H]N(C(=O)C1=C(C2=C(S1)N=C([H])N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C(=C2[H])C([H])([H])OC([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C1=NC(=C([H])S1)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OP(=O)(O[H])OC([H])([H])C([H])(C([H])([H])OP(=O)(O[H])O[H])C([H])([H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C2=C(N([H])C(=O)N3C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[C@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N=C([H])N1[H])C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(N(C(=O)[C@@]([H])(N([H])C3=O)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C2N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=O)N(C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])ON2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(=O)N([H])C(C1=NN=NN1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C(\C([H])=C2/OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3C2=O)C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1N=C([H])C([H])=C2[H] [H]N(C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N1C(=O)C(=O)C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C2=NC(=C([H])C([H])=N2)C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])=C([H])C([H])([H])N2N1C(=O)N(C2=O)[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])SC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N1N=C(C([H])=C([H])C1=O)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2O[C@]3([H])[C@@]45C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C4([H])[H])[C@]51C([H])=C([H])[C@@]3(OC([H])([H])[H])[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])[H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(=C2C3=NC([H])=C(SC#N)C([H])=C3C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC([H])=C(S1)C#N)C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2(N(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=N1)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C1=C(N=C2[H])C([H])=C([H])C(C#CC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC([H])([H])[C@@]([H])(C#N)N([H])C(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]O[C@]1([H])[C@@]([H])(O[H])[C@@]([H])(O[C@]([H])(C([H])([H])N2N=NC([H])=N2)[C@@]1([H])O[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C([H])([H])C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])O1 [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N1C2=C(C([H])=C([H])C([H])=C2[H])[C@]2(C([H])([H])[C@]3([H])N(C(=O)[C@@]([H])(N([H])C3=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]12[H])[C@@]12C3=C(N([H])[C@]1([H])N1C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C([H])=C3[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C(=O)C2=C(C([H])=C(O[H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2SC([H])([H])C(=NN12)C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=NC(=N1)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])OC([H])=N1 [H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N2N=C(N=C2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2C3=C(C([H])=C([H])C([H])=C13)[C@@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H] [H]C1=NN(C2=C1[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(F)(F)F [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(F)C(=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N2N1N=C(C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C1([H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(N=C1[H])C([H])([H])C1=C(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@@]([H])(F)C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])=C([H])C([H])=C1[H] [H]C1=NN(C2=C1C1(OC([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1=C(C(=C([H])S1)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C2ON=C(C2=C1[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]O[C@]([H])(C([H])([H])F)C([H])([H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C2=C([H])C(SC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N=C1[H] [H]N(C1=C([H])C([H])=C([H])C(=N1)C1=NN([H])C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H] [H]C1=NN2C([H])=C([H])C([H])=C([H])C2=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])C(=C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]O[C@@]([H])(C1=C([H])N=C(N2C([H])([H])C([H])([H])N(C3=NC4=C(N3[H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])[H] [H]N1C(=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])=NN=C2N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(OC2([H])C([H])([H])N(C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(C(=O)N([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1Cl [H]ON([H])C(=O)[C@]([H])(N([H])[P@@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Br)C([H])([H])C1([H])[H] [H]N(C1=NC(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OP(=O)(O[H])C(F)(F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@](N1N=NC2=C1C([H])=C([H])C([H])=C2[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])[C@]([H])(O[C@@]2([H])C([H])([H])N([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC1(C2=C([H])C([H])=C3C([H])=C([H])N(C3=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])[C@@]1(OC([H])([H])C2=C(N=C(N=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(SC(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OP(=O)(O[H])C(F)(F)C1=C(Br)C([H])=C2C([H])=C([H])C(=NC2=C1[H])C(=O)N([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])N(C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(F)(F)C([H])(F)F)=C1[H])C(F)(F)F [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])N1\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Br)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N1C(=O)C(N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] COCCCC1=[N+]([O-])C=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CC=C(N=C2)N2CC[C@H](C2)OC2=C(Cl)C=C(C)C=C2Cl)=C1 [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2N(C(=O)C([H])([H])[H])C([H])([H])C2=C(OC([H])([H])F)C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=NN(C(=O)C2=C1[H])C([H])([H])[H])C1=C(C(=O)C2=C(O1)C([H])=C([H])C(F)=C2[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C1=NC([H])=C(F)C(=C1[H])C1=NN(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] COCCCNC(=O)CCN1C=CC2=C(NC3=CC=C(OC(F)(F)F)C=C3)N=CN=C12 [H]C1=C([H])C([H])=C2O[C@@]([H])(C(=O)N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])S(=O)(=O)C3([H])[H])C([H])([H])OC2=C1[H] COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC(=CN=C3)C3=CN=C(N)C=C3)C2=O)C=C1 [H]N(C1=NC(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(N=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C(=C2Cl)C([H])([H])OC2=C3N=C(C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C2C(=NC(=N1)N([H])[H])N([H])C(=C2SC1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C(Br)=C(S1)C1=C([H])C(N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2N([H])[H])=C([H])C([H])=C1[H] [H]OC1=C(Cl)C([H])=C2C(N([H])C(=NC([H])([H])C2([H])[H])C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H] [H]C1=C([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C(C(=O)N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])[C@]5(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C5([H])[H])C4([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]13C([H])([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@]21C([H])([H])C(=O)C([H])([H])C3([H])[H] [H]N1C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=NC2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])=C([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C(N=C(N2C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])C([H])([H])[H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=N1)N([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC(=C([H])N12)C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C(=C1[H])[N+]([O-])=O [H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC(=O)C1=NN([H])C2=C1C([H])([H])[C@]1([H])[C@@]2([H])[C@]1([H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(O1)C1=NN2C([H])=NC3=C(SC(=S)N3C3=C([H])C([H])=C(Cl)C([H])=C3[H])C2=N1 [H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(N=C2N1C(=O)C(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])=C(N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]\C(=C(\[H])[C@@]1([H])C2=C(C(F)=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])C(=O)OC([H])([H])[C@]12[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(N([H])C(=O)C1=C([H])C2=C(N(C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H] [H]N(C1=NC(=NC([H])=C1[H])N1C([H])=NC2=C1C([H])=NC([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=NN(C([H])=C1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C(\C([H])=C2/S\C(=N/C([H])(C([H])([H])[H])C([H])([H])[H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2S(=O)(=O)N1C([H])([H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C(SC2=C(C([H])=N1)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)OC2(C([H])([H])C2([H])[H])[C@]2([H])N([C@]([H])(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])OC2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C(C3=C([H])C4=C(OC([H])([H])C([H])([H])O4)C([H])=C3N=C12)C([H])([H])[N+]1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C(=O)N([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N([H])C(=N\[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])\N([H])C(=O)C1=C([H])C([H])=C([H])C(F)=C1C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NN(N=C1N([H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=NC([H])=C([H])N=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] COC1=C(OCCCCOC2=CC3=CC=CC=C3C=C2)C2=C[N]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3 [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N2C([H])=NN=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])N=C(S[C@]2([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C3([H])[H])C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=N1 [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=N[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=C1[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1C1=C([H])C(Cl)=C2C(=O)N(C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C#N)C(OC3=C([H])C([H])=C(Br)C(=C3[H])C([H])([H])N3C(=O)C([H])([H])[N@](C([H])([H])C3([H])[H])C2([H])[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)[C@]2([H])ON(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[N+]([O-])=O)[C@]2([H])C1=O [H]C1=C([H])C([H])=C(N2N=C3C(=C2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C3=O)C([H])([H])C([H])([H])[H])C(Cl)=C1[H] [H]N(C(=O)C([H])([H])C1=C(N(C2=C1C([H])=C(F)C([H])=C2[H])S(=O)(=O)C1=C(C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F [H]SC(=N[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]N(C1=NC([H])=C(C#N)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(N([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C2C([H])=C([H])SC2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])[C@@]2([H])C3=NC([H])=C(Br)C([H])=C3C([H])([H])C([H])([H])C3=C2C(Br)=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]OC1=C([H])\C(=N\C2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C3=NC([H])=N2)C(=O)C([H])=C1OC([H])([H])C1=C(F)C(F)=C(F)C(F)=C1F [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])O\N=C(\C([H])([H])N1C([H])=NC([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(\N=C2/SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C(F)(F)C(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C(C#N)(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C#CC([H])([H])C([H])([H])C([H])([H])N1C(=NC2=C(N=C(F)N=C12)N([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1Cl [H]N1C(=O)N([H])[C@]2(C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1SC([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])OC2=C([H])C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(N2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C(C([H])=C([H])C(C#N)=C1[H])C([H])([H])O[C@]([H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(N(C(=N2)C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])O[C@@]2(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])=C([H])C([H])=C2C1=O [H]OC1=C(C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H] [H]N(C(=O)[C@]1([H])C(=O)N2C3=C(C([H])=C([H])C([H])=C13)C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=N1 [H]C1=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])[N+](=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H][C@@]12C[C@]1([H])[C@H]([C@H](O)[C@@H]2O)N1C=NC2=C1N=C(N=C2NC)C#CC1=C(Cl)C=CC=C1 [H]ON(C([H])=O)[C@]([H])([C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C2=C(N=C([H])N=C2N2C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]SC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2N([H])C(=O)C([H])([H])C([H])([H])C2=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[P@@](=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(OC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=NC(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C1=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C1=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H] [H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C([H])=C(C(=NC2=NC([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])N([H])C(=O)C4=NC(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C([H])N4C([H])([H])OC([H])([H])[H])=C([H])C([H])=C3N=C12)C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(N([H])C(=O)[C@@]2([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C2=NC3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1C(=O)N([H])C(=O)C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=NC(=C([H])O3)C3=C([H])C([H])=C([H])C([H])=C3C#N)C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])N([H])C(=O)C1=C([H])C([H])=C([H])N1[H] [H]N1C(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])C2=C([H])C(C#N)=C([H])C([H])=C2OC([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2([H])C([H])([H])C2([H])[H])C([H])=C1OC1=NC([H])=C(C([H])=C1Cl)C(F)(F)F)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C#N)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=O [H]N([H])C1=NC(=C(S1)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C1(C2=C([H])N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C(OC([H])([H])C(=O)O[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] ClC1=CC=CC=C1C1=C(N=CO1)C1=CC2=C(S1)C1=NC=CC=C1OCC2 [H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]1([H])O[H] [H]OC(=O)C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC3=C(N(N=C3C(=O)N([H])[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=NN=C(S1)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(O1)C1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(N=C1C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C(OC([H])([H])[H])C(C(=O)N([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C(Cl)=C1[H]