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[H]OC1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=C(N=C([H])O1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]N([H])C(=O)N([H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@]4(N=C(N(C4=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])N(C2=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])C([H])([H])N(C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])/C([H])([H])[H]
[H]N(C(=O)O[C@]1([H])C([H])([H])[N@@]2C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C2N=C([H])C([H])=C([H])C2=C(Cl)C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N([H])C(=O)N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[C@]1([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3[C@@]1(C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C#N
[H]\C(=C(\N1N=C([H])N=C1[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(C#CC2=C([H])C([H])=C([H])C([H])=C2\C([H])=N\N2C(=O)OC([H])([H])C2([H])[H])=C([H])C(=N1)C([H])([H])[H]
CN(CC1=CC=C(C=C1)C1=NCCN1)C(=O)COCCN(C)S(=O)(=O)C1=CC=C(Cl)C(C)=C1Cl
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
C[Si](C)(C)C1=CC=C(C=C1)N1CCN(CC1)C1(C(=O)NC(=O)NC1=O)C1=CC=C(OC2=CC=C(Br)C=C2)C=C1
[H]N1C(=O)[C@](C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C12)(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@@](C1=C([H])N=C(Cl)C([H])=C1[H])(C1=C([H])C(=C([H])C(F)=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(OC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])[H]
[H]N1C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=[N+](C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=NC([H])=N4)C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]OC([H])([H])[C@]([H])(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])[C@]([H])(C([H])([H])O[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(OC([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C23)=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N1C([H])=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])N(N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])[C@@](N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)(C1=O)C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]O[C@]1([H])C2=NC(=C(C(=O)N2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NOC3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C2=C1C(=O)N([H])C([H])([H])C2([H])[H]
[H]N1C(=O)N([H])C(N2C([H])([H])C([H])([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])=C(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C(=O)[C@]([H])(C1=NN=C2N1C([H])=C(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(N([H])[H])=C2N=C(C(=NC2=C1[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC(=O)N1CC2CC1CN2CC1=CC2=CC=C(OC3=NC4=CC=CN=C4S3)C=C2O1
[H]C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O
[H]C1=C(C([H])=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])([H])C2=C1C(OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NC([H])=C2[H]
[H]N(C(=O)C([H])([H])N1C([H])=NC(=C1C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
OCC1=CC=CC(=N1)C#CC1=CC=CC(=C1)C#N
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)[C@]23C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@](C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])(C4([H])[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C2C([H])=C([H])C2=C3OC([H])([H])O2)C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C2=C(N(C([H])=C2C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC(=C1[H])N(C([H])([H])C1=C([H])C([H])=C(C#CC([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C#N
CCCC1=C(C2=NC(=NO2)N2CCCC2)C(C(=O)OCC)=C2N1N=C(C=C2C1=CC=CC=C1)N1CCOCC1
[H]C1=C([H])C(F)=C(C([H])=C1F)N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3C(=C([H])C([H])=C2[H])C(=O)N(C3([H])[H])[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H]
[H]O\N=C1/C2=C(C([H])=C(C([H])=C2[H])C2=C([H])N(N=C2C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C2N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]3([H])C([H])([H])C([H])=C([H])[C@@]3([H])C2=C(C([H])=C1[H])[N+]([O-])=O
[H]N([H])C1=NC(N([H])[H])=C2C([H])=C(C([H])=NC2=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C(\C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3N=C12)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C(=O)[C@@]12O[C@]([H])(O[C@]1([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3([H])[C@@]([H])(O[H])C([H])([H])[C@]21C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C(Br)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
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[H]C1=C([H])C([H])=C2N(N=NC2=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])C([H])([H])[H]
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[H]N(C(=O)C([H])([H])[C@]1([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
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[H]N=C(N([H])[H])C1=C([H])C2=C(N([H])C3=NC([H])=C([H])C([H])=N3)C([H])=C([H])C([H])=C2S1
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[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(N([H])[H])=C2[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]1([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=C([H])C(OC2=C([H])C([H])=C3N([H])C(=NC3=C2[H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@](C(=O)C2=C([H])C([H])=C(Cl)C(Cl)=N2)(C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C(=O)C1=C([H])C([H])=C([H])S1
[H]N(C(=O)OC([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C([H])N=C4N([H])C([H])=C([H])C4=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]\C(=C1/C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])N1C(=O)N(C2=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=NN([H])C([H])=N1
[H]N(\C(=N/S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])N1N=C([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)C(=N\OC([H])([H])C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(N=C(SC([H])([H])[H])N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=NC([H])=C2[H])=C1C([H])([H])[H]
[H]N([H])C([H])([H])C(\[H])=C(\F)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2S1)C([H])([H])N(N1C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C(O[H])C([H])=C(C([H])=C1O[H])C(=O)O[C@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N(\C(=N/C#N)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(C1=C([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C1C(=O)C2=C(C([H])=C([H])S2)[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]1([H])C([H])([H])OC(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])[H])C1=NC([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1
[H]OC1=C(Cl)C([H])=C2C(N([H])C(=NC([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C(O[C@]3([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(N=NC2=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C1=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])N21)C([H])([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C1=NC(O[H])=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
COC1=CC=C(\C=C\C2=C(/C=C/C(=O)N3CC(C)CC(C)C3)C(OC)=CC(OC)=C2)C=C1
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)C(F)(F)F)C1=C([H])N2C(=NC(=C2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1=C(N=C(C(=N1)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]21C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=NN=NN2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])[N+]([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]C1=C(N2N=NC3=C2N=C(N=C3N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)[C@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])C(=O)C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])OC([H])([H])[H])\C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])SC1=NC2=C(C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H]
[H]OC(=O)[C@]([H])(C1=C([H])C2=C(SC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(\C([H])=C(/[H])C3=C([H])C([H])=NC([H])=C3[H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C(=O)OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N(C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1([H])N(C(=O)C2([H])N(C(=O)C([H])([H])N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[C@]1(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
COCC1=C(O)C=CC(OCC(O)CNC2CCN(CC2)C2=NC=NC3=C2C(=CS3)C2=CC=CC=C2)=C1
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N[C@@H]1CC[Se]C1
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C(=C2[H])C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2OC([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C1=C([H])N([H])C2=C1N=C([H])N([H])C2=O
[H]OC(=O)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])ON=C(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])N(C(=C2C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(P(=O)(O[H])O[H])P(=O)(O[H])O[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])N([H])[H]
[H]OC(=O)C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
CC(C)C[C@H](CO)NC1=NC(SCCC2=CC=CC=C2)=NC2=C1SC(N)=N2
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC2=NN([H])C(=C2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N=C([H])S1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])N=C([H])C([H])=C1N([H])N([H])C1=NS(=O)(=O)C2=C(S1)C([H])=C([H])N=C2[H]
[H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C2C(SC3=C2C([H])=C([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C3=O)=N1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C2C3=C1C(=O)C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C2([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C(=O)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
[H]N(C(=O)C1=NC(=C(N1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C([H])([H])[H])=C2C(=N1)[C@@](OC2([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C#N
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@]2([H])C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC(=NC([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1[C@@]([H])(C2=C(C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])[C@]1([H])C1=C(O[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
COC1=CC(CN(CCCN2CCOCC2)C(=O)NC2=CC=C(C=C2)C2=CNN=C2)=CC=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])[C@]11O[C@]([H])(C([H])([H])[H])[C@]([H])(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])N([H])C1=O)C(=O)N(C([H])([H])[H])C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1N([H])[H])[N+]([O-])=O
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3C([H])([H])SC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(O2)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@]2([H])C1([H])[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C2=C([H])N(N=N2)C([H])([H])C(C([H])([H])O[H])(C([H])([H])N2N=NC(=C2[H])C([H])([H])OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])C([H])([H])N2N=NC(=C2[H])C([H])([H])OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])C([H])=C1O[H]
[H]N1C([H])=C([H])N=C1C1=NN(N=N1)C1=C([H])C(F)=C([H])C(C#N)=C1[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])N=C1[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C2\C(=O)N([H])C3=C2C([H])=C(I)C([H])=C3[H])C([H])=C1Br
[H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(O[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC#N
[H]N1C2=C(N=C3C([H])=C([H])C(=C([H])N23)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]N(C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])C(=NC([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C3C([H])=C(OC4=C(C#N)C([H])=C([H])C(=C4[H])C([H])([H])N4C([H])=NC([H])=C4C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C3=C([H])C([H])=C2[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)\C(=C(\[H])C2=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C2=C(C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C([H])C(=NC(=N1)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])N=C([H])C(=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])([H])C([H])([H])C2=C1SC([H])=C2[H]
[H]N(C1=NC(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C2N=C([H])N([H])C2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=N1
[H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1\C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C12
[H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C(F)(F)F
[H]N=C(OC([H])([H])[H])N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
[H]C1=C([H])C([H])=C(N2C(=C(C3=C2C([H])([H])C([H])([H])N(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C3=O)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(Cl)=C1[H]
[H]N(C(=O)C([H])([H])OC1=C2C(SC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])N([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])[C@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C([H])C(=C23)C1([H])[H]
[H]O[C@@]1(C2=C(C3=C(N2[H])C(Cl)=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(OC([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1Cl
[H]O[C@]1(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N2C(=NC(=C2C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C([H])=C([H])C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]N(C(=O)C(F)(F)C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)OC([H])([H])[H]
[H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2C([H])=C([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=C([H])C(Cl)=C(F)C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=C(Cl)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C(=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C2=C([H])C([H])=C(N=C2OC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=NN=C([H])S1
[H]N=C(N([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C3=C(C([H])=C(C([H])=C3C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(=N[H])N([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC2=C1N=C(N=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=NN([H])C2=C1C([H])([H])[C@]1([H])[C@@]2([H])[C@]1([H])C([H])([H])OC([H])([H])[H]
[H]OC1=C(O[H])C(Cl)=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])N=C1[H])C1=C([H])N=C(S1)N([H])C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C#CC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@](C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N([H])C([H])=NC([H])([H])[C@@]2([H])O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C(O[H])C([H])=C(O[H])C([H])=C1O[C@]1([H])O[C@@]([H])(C([H])([H])O[H])[C@]([H])(O[H])[C@@]([H])(O[H])C1([H])[H]
[H]N(C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
Cc1cnc(NCC(F)(F)F)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]C1=C([H])C(C2=C([H])C([H])=C(Br)C([H])=C2[H])=C(C([H])=N1)[C@]1([H])N(C(=O)C([H])([H])[S@]1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)C(C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)C1(C(=O)N2C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C([H])C(C#N)=C1[H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C2=C([H])C3=C(N2[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])OC2=C([H])C([H])=C(O[H])C([H])=C2[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]OC1=C2\C(=C(/[H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@]1([H])C([H])([H])C([H])([H])C(=O)[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(O2)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]2([H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=NC2=C1N=C(N1N=C(N=C21)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C(F)C([H])=C1C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H]
[H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C4(SC3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])[H])N(N=C2SC([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)N1C([H])([H])C([H])(N2C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=NC([H])=NC([H])=N2)=C1[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N(C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NN2C([H])=C([H])C([H])=C(C#CC3=C([H])C([H])=C([H])C([H])=C3N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(OC2([H])C([H])([H])C([H])([H])N(C3=NN=C(C([H])=C3[H])C3=NN=C(O3)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C(F)(F)F
[H]N([H])N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C2([H])[H])=NC2=C(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1N=C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C1C(=O)N(C2=O)C1=C([H])C([H])=C([H])C([H])=C1F
[H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C(=C([H])C([H])=C3[H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@]12[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C(=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H]
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[H]N(C(=O)N([H])C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C(=O)C1=C(F)C([H])=C([H])C([H])=C1F
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C1C2=C([H])C([H])=C3[H]
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[H]C1=C([H])C(=C(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(N4C([H])([H])C([H])([H])N([C@@]5([H])C6=C(C([H])=C(C([H])=C6[H])C(F)(F)F)C([H])([H])[C@]5([H])OC([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C4([H])[H])C([H])([H])[C@@]3([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=NC(=C(C(=O)OC([H])([H])[H])[C@]2([H])C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1OP(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])[N+]([O-])=O
[H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C(F)(F)F
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])(N(C(=O)C3=C([H])N(C([H])=N3)C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C(OC(F)(F)F)=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(N1C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1C(SC([H])([H])C(=O)C2=C(C(C(=O)OC([H])([H])[H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])=NC2=C(C(=C([H])S2)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C1=O
[H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C(Cl)=C([H])C(=C2[H])C(F)(F)F
[H]ON([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)OC([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])([H])N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)N1\C(SC([H])([H])C1([H])[H])=N\C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NN(C2=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(N2C([H])=NC3=C(C4=NC5=C([H])C([H])=C([H])C([H])=C5N=C4N3C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C2=O)C(OC([H])([H])[H])=C1[H]
[H]N(C1=C([H])N=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])N([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1Cl)S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/N([H])C(=O)C(=C1C1=C([H])C([H])=C([H])O1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(S[C@@]([H])(C(=O)O[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C3=C2C2=C(C4=C(C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])N5C([H])=NC([H])=C5[H])=C4[H])N2C1([H])[H])C1=C3C([H])([H])N([H])C1=O
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[H]C1=C([H])C2=C(O1)C(Br)=C1C([H])=C([H])OC1=C2C([H])([H])[C@]([H])(C([H])([H])[H])[N+]([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]C1=C([H])C2=C(C([H])=C1[H])N(N=N2)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
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[H]N1C([H])=C(N=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])C([H])=N1)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C3=NC([H])([H])C([H])([H])C([H])([H])N3[H])=C([H])C([H])=C2[H])C([H])=C1OC([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N1C([H])=C([H])C2=C(N=C([H])N=C12)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C2=C([H])SC([H])=C2[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2(C([H])([H])C2([H])[H])C1([H])[H]
CN1CCCN(CC1)C1=C2C=C(NC2=NC(N)=N1)C1=CC=C(F)C=C1
[H]N([H])C(=O)C1=C(C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N1[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])[H]
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(OC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])=N1
[H]C1=C([H])C(=C2N=C(N(C2=C1[H])C1=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C(F)C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N([H])S(=O)(=O)C1=C([H])C2=C(S1)S(=O)(=O)C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)C1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])N(N=C(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C1([H])[H])C1=NC(=O)C([H])([H])S1
CCCC(CCC)COS(N)(=O)=O
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C1=NC([H])=NC2=C([H])C(Cl)=C([H])C([H])=C12
[H]N(\N=C(/[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=NC([H])=C1Cl
[H]N(C1=C(N=C(OC2=C([H])C(=C([H])C([H])=N2)C([H])([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1O[H])[C@]1([H])C3=C(C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])N([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]C1=C(C([H])=C2SC(=NC2=N1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(C#N)=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C(F)C(F)=C([H])C([H])=C2[H])=NC2=C1C([H])=C([H])C(=O)N2[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])N(N=C1[H])C([H])([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C2=C([H])C(=NC2=C(N=C1C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C([H])([H])C([H])([H])N(C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC([H])([H])[H])N=C2N3C(=NC(=C3C(=NC2=C1[H])[S@](=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=C(O)C=CC(CCNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NC3CCCC3)=N2)=C1
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C3([H])[H])=C([H])C(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]C1=NC(=C(N1C([H])([H])[H])S(=O)(=O)OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[N+]([O-])=O
[H]C1=C(C([H])=C(C(=C1[H])S(=O)(=O)C([H])([H])[H])[N+]([O-])=O)C1=NC(=C(S1)C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C1=NC2=C([H])C(OC3=C([H])C(=NC([H])=C3[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N([H])C1=C(N(C(=O)C([H])([H])N2N=C([H])C(Cl)=C(Cl)C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C(=O)N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=NC2=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC([H])([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])O1
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=S)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])C(O[H])=C([H])C([H])=C1[H]
[H]N([C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C(\[H])=C(\C1=C([H])C([H])=C(Cl)S1)C([H])([H])[H]
[H]OC(=O)C1=C(O[H])C([H])=C(N([H])C(=O)N([H])C(=O)C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(Cl)=C1[H]
[H]N(C(=O)C([H])([H])N1N=C([H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1OC2=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])C2=C([H])C(Cl)=C([H])C([H])=C2N=C1C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H]
[H][C@@]12C[C@@H]3C[C@@H](C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)CN1N=CN=C1CCCC1=CC=CC=C1
[H]OC1=C(N([H])[H])C([H])=C2C([H])=C3C(=NC2=C1[H])C1=C([H])C2=C(C(=O)N1C3([H])[H])C([H])([H])OC(=O)[C@]2(O[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]N1C([H])=NC2=C(SC3=C(Cl)C([H])=C([H])C(Cl)=C23)C1=O
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])S1)C(=O)N([H])C([H])([H])[H]
[H]N([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(=C(/[H])C1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])SC([H])=C2[H])=C1[H])[N+]([O-])=O)\C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H]
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[H]N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C(SC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C(=NO1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(C#N)C(=NC(=C1[H])C1=C(O[H])C([H])=C([H])C([H])=C1[H])N([H])[H]
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[H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=S)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C(N([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N1C(=O)[C@@](C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=NC4=C3C([H])=C([H])C([H])=C4[H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(OC([H])([H])[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])SC1=C([H])N=C(S1)N([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C2N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[C@@]1([H])N(N=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H])C(=O)C([H])([H])[H]
[H]ON1C([H])=C([H])C([H])=C(C1=O)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])S1)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NN(C([H])=C1Br)C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C2=C([H])C3=C(C([H])=C(Cl)C([H])=C3[H])N2C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3OC([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
C(CC1=CC=CC=C1)SC1=NC2=CC=CC=C2N1
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[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])N1[H])C1=NN([H])C([H])=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(S1)C1=NC(Cl)=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C3OC([H])=C([H])C3=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N(C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=NC([H])=C([H])N=C2C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=C(C3=C([H])N=C(N=C23)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C4(C(=O)N5N(C4=O)C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]C1=NC2=C(C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])[C@@]2([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])O[C@@]([H])(O[C@]1([H])C1=C(O[H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C2=C(N([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C4=C(OC([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC1=C(O)C=CC2=C1CN1CCC3=C(C=C4OCOC4=C3)[C@@H]1C2
[H]N=C(N([H])[H])C1=C([H])C(=C(SC([H])([H])[H])S1)C1=C([H])SC(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
FC1=CC=C(C=C1)[C@@H]1CNC[C@H]1C1=NC2=CC=C(C=C2C(=N1)N1CCC1)C1=CNN=C1
[H]N1C(=O)N(C(=O)\C1=C(\[H])C1=C([H])C([H])=C(O1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)O[H])C1=C([H])C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])P(=O)(O[H])O[H]
[H]N(C1=NN=C([H])N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(N=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(O[H])=C(C([H])=C2C([H])([H])C([H])([H])[H])C2=NN([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C3=C(C([H])=C(S3)C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]21[H]
[H]N([H])C(=O)C(=N/OC(=O)C1=C([H])C([H])=C([H])O1)\C1=NC(=C([H])S1)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C1=NC(=NN1C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(SC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])[H]
[H]O[C@@]([H])(C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([O-])=O)C([H])([H])C([H])([H])SC([H])([H])[H]
[H]C1=C([H])C([H])=C(C(=C1[H])C1=NN=C2SC([H])([H])C(=NN12)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C(=NN2N=C1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]\C(=N/OC([H])([H])[H])[C@@]1([H])C([H])([H])[N@@]2C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
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[H]N([H])N([H])C(=O)C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C12)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H]
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COC1=CC(=CC=C1)N(C)C(=O)C1=CC=C(S1)C1=CC=CC(OC)=C1F
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[H]N([H])S(=O)(=O)C1=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])[H])=C(SC2=C([H])C(F)=C([H])C([H])=C2[H])N=C1[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@]3([H])N(C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C3C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]N(C(=O)C1=C2C([H])=C([H])C([H])=C3C4=C([H])C([H])=C([H])C([H])=C4C(=O)C(N=C1[H])=C23)C([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)OC1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])=C1[H]
COC1=CC(COC2=CC=C3N(CC=C)C=C(CC(=O)NC4CCCCC4)C3=C2)=CC=C1
[H]C1=NC2=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C(=N2)[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3N(C([H])=C([H])C3=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)OC1=C([H])C([H])=C2C(OC(=O)C(=C2C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C2N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C(N2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C(=C([H])C([H])=C1C([H])([H])C(=O)N(C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])[H])C([H])([H])N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)SN(C1=O)C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]5([H])OC5(C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(N([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C(N([H])[H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]OC1=C([H])C2=C(OC(=N2)C2=C(N=C([H])C(=C2[H])C2=C([H])N(N=C2[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N([H])[H])C([H])=C1[H]
[H]N1C([H])=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC([H])=C(C(=C1[H])N(C(=O)C(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])=C([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])=C(C([H])=C1C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])[H]
NS(=O)(=O)NC1=CC=C(NC(=O)NC2CCCCC2)C=C1
[H]C([H])=C1C([H])([H])C([H])([H])O[C@]11C([H])([H])C([H])([H])[C@@]2([H])[C@@]3([H])C(=C4C(=C([H])C(=O)C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])C([H])([H])[C@]12C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)OC([H])([H])[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@]([H])(OC([H])([H])C1=O)C([H])([H])[H])C1=C([H])C([H])=C(C#N)N1C([H])([H])[H]
CC1=CC=CC(F)=C1NC(=O)C1=NC2=C(NS(C)(=O)=O)C=CC=C2C(O)=C1
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]S\C(=N/C([H])([H])C1=C(Br)C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C(Br)C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]\C(=N/S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C(\C([H])=N/N=C2\SC([H])=C(N2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])O[C@]([H])(C([H])([H])[H])[C@]2([H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]2([H])C(\[H])=C(/[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]ON([H])C(=O)[C@@](C([H])([H])[H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C1=NC(=NO1)C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C(Cl)C(Cl)=C1[H])C([H])([H])N1C2=NC(=C([H])C(=O)N2N=C1C1([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(N=C1C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=NC(SC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=NN1[H]
[H]N(C(=O)C1=C([H])N(C([H])=N1)C([H])([H])C1(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NN(C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(OC2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@]1(O[C@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C(F)(F)F
[H]OC(=O)C(OC1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C(N(N(C1=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=NC2=C1[H]
[H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H]
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[H]N(C1=NC(=O)\C(S1)=C(/[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
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[H]N1N([H])C(=NC1=S)N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C1=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23
[H]C1=C([H])C(Cl)=C2N(C(=O)C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C([H])([H])OC([H])([H])[H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=NC2=C(N1[H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C(F)(F)F
OC1=CC(=CC2=CC=C(NC3=CC=CC=C3)C=C12)S(O)(=O)=O
[H]C1=C([H])C2=C(S1)C(=NN(C2=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])[H]
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[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N(N=C1[H])C1=NC(=C([H])S1)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C(F)(F)F
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[H]N1C(=C([H])C(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
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[H]OC1=C(C#N)C2=C(C(SC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])=N1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
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[H]N(C(=O)C1=C(N(N=C1C1=NN=C(O1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C(=O)[C@@]([H])(C1([H])[H])[C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)C4=C([H])C(F)=C([H])C([H])=C4[H])C(=C23)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C(OC([H])([H])[H])=C(C2=C1C(=O)OC2([H])[H])C([H])([H])[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])P(=O)(OC([H])([H])[H])OC([H])([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])N4C([H])=C([H])C([H])=C([H])C4=N3)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H]
[H]N([H])C1=NC2=C(C([H])=C(C([H])=N2)C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[H])C(=N1)N([H])[H]
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[H]SC([H])([H])[C@@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S([O-])(=O)=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(N=C(N1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])[C@@]([H])(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])[H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=S)N([H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C2SC([H])=C3[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1Cl)C(=O)N([H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C1=NC2=C3C(=O)N([H])C(=O)C(C3=C([H])C([H])=C2N1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
O=C(NC1=NOC2=C1C=CC=C2)C1CCN(CC1)C1=NC(=NS1)C1=CC=CC=C1
[H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C(\[H])=C(/[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=C(C(=O)OC([H])([H])[H])C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C2=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)=C2[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H]
[H]OC1=C([H])C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)=C([H])C([H])=C1[H]
[H]N([H])C(=[N+]([H])[H])C1=C(Cl)C([H])=C2N([H])C(=C([H])C2=C1[H])C1=C([O-])C(=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])O[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
C[C@@]1(N=C(N)OCC1(F)F)C1=CC(NC(=O)C2=NC=C(OCC#C)N=C2)=CC=C1F
[H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C3=C(OC(=O)C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])N1C2=C(SC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]3([H])N(C(=O)[C@@]4([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])[C@@]([H])(O[H])C3([H])[H])C([H])([H])C3=C([H])C([H])=C([H])S3)C([H])([H])O[H])C1=O)C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N(C(=S)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C(OC([H])([H])[H])=NC([H])=N1)C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])O1
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H]
C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C(=O)C1CC1
[H]OC([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])O[C@]1(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C2=C(C([H])=C(Cl)C([H])=C2[H])C2=C1C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])[C@](C(=O)OC([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]O[C@@]1([H])[C@]([H])(N([H])[H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2C([H])([H])C(=O)C2=C([H])C([H])=C([H])C(=N2)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC1=NC2=C([H])C(C#CC([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C(F)=C4[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1[H]
[H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(C2=C([H])N=C([H])C([H])=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H][C@]12C[C@](O)(CCN1CCC1=CC(OC)=C(O)C=C21)C1=CC=C(OC(F)(F)F)C=C1
[H]OC(=O)C1=C([H])C(Cl)=C(N2C(=O)N([H])C([H])([H])C3=C2C([H])=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=N3)C(Cl)=C1[H]
[H]N(C(=O)OC([H])([H])[C@]([H])(OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
CC1=C(C=C(C=C1)C(=O)N[C](=O)(NCC1=CC=C(C=C1)N1N=C(C=C1NC(=O)NC1=CC=CC2=CC=CC=C12)C(C)(C)C)C1CCCC1)C(O)=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])S1(=O)=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=NN2N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)NC1=CC=CC=C1
[H]N1C(=NN(C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C3=NC(=C([H])C(=C3N=C2C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[S@]1=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=C([H])C(N=[N+]=[N-])=C2[H])C([H])([H])N=[N+]=[N-])C([H])=C1[H]
[H]N=C(SC([H])([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]\C(=N/N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C(=C3N=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])N1C(=O)N(C2=C(N(C(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H]
CCCCN1C(C)=C(C)C=C(OC2=NC3=CC=CC=C3O2)C1=O
[H]SC1=NN=C(N1N([H])[H])C([H])([H])SC1=NN=C(N1N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)OC([H])([H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C1=C(Cl)C([H])=C([H])C2=C1OC([H])([H])O2
[H]N(C(=O)N([H])[C@@]1([H])[C@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(O[H])(C(F)(F)F)C(F)(F)F
[H]N(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON(C([H])=O)C1(C([H])([H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]ON([H])C(=O)[C@@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2N(C1([H])[H])S(=O)(=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N([H])C(=O)C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C(Cl)N=C([H])C(=C1[H])C([H])([H])N1C([H])=C(C(C#N)=C1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])C1=C2N=C(N(C2=NC(F)=N1)C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(I)C([H])=C2OC([H])([H])OC2=C1[H]
CC1=CC(N)=NC(CCC2=CC=C(CCCN)C(CCC3=CC(C)=CC(N)=N3)=C2)=C1
[H]N1N=NC(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C(=O)[C@@](C([H])([H])[H])(C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C1Cl
[H]C([H])([H])C1=C(C(=O)ON1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])[C@]([H])(N1C([H])=NC([H])=C1[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C(F)C(F)=C(F)C([H])=C1[H]
NC1(CCN(CC1)C1=NC=NC2=C1C=CN2)C(=O)N[C@@H](CCN1CCCC1)C1=CC=C(Cl)C=C1
[H]C1=C([H])C(=C([H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])N([H])C([H])([H])C([H])([H])C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N1N([H])\C(C(=C1[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])=C1/C([H])=C([H])C(OC([H])([H])[H])=C([H])C1=O
[H]OC([H])([H])C([H])([H])OC1=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C(=NC(=N1)C([H])([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1(N([H])C(=O)C2=C([H])C(=C(N(C2=O)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2=C(C3=C(C([H])=C([H])C([H])=C3[H])[C@@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C2=C(N(C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(SC([H])([H])[C@]([H])(N([H])C1=O)C(=O)O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C([H])=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C(C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C([H])C([H])=C([H])O2)=NC2=C1SC(=O)N2[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(\C([H])=C3/SC(=S)N(C3=O)C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2O1
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F
[H]OC1=NC(=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C#C[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C([H])N=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])F)=C1[H]
[H]N1C([H])([H])C([H])(C1([H])[H])[C@]([H])(OC([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C(N([H])C3=C4C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C4=NC([H])=C3[H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
CCCCCCCCN1C=C(CNS(C)(=O)=O)C2=CC(=CC=C12)C1=CC(C)=CC=C1
C[C@@H]1CCN(C[C@@H]1N(C)c1nc(Nc2ccc(cc2)N2CCOCC2)nc2[nH]cnc12)C(=O)CC#N
[H]N(C(=O)N1C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C(=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C3N=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C2=C(OC(=C([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1
CCC1=NC2=C(N1[C@H]1CCC3=C1C=CC(=C3)C1=CC=CC=C1C1=NN=NN1)C(=O)N(CC1=C(C=CC=C1)C#N)C=C2
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
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O=C(CC1=CC=CC=C1)NC1=NC(=NC2=CN(N=C12)C1=CC=CC=C1)C1=CC=CC=C1
[H]N([H])C1=C(N([H])C(=O)N([H])C1=O)C(=O)OC([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(S1)C1=NN=C(O1)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N([H])C1(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])N=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=N2)C1=C([H])C([H])=C([H])C([H])=C1F
[H]O[C@@]1(C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[C@]11C(=O)N(C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]\C(=C1/C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]ON([H])C(=O)[C@](C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N([H])C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
COC1=CC(OC)=C2C(=O)C=C(OC2=C1)C1=CC(OC)=C(OC)C(OC)=C1
[H]N(C(=O)C1=C([H])C([H])=C2N(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C(=O)N(C2=C1[H])C([H])([H])[H])C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C(F)C(F)=C([H])C([H])=C2F)C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2SC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N([H])C1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]ON1C2=C(C(=NN2C([H])([H])C(=O)O[H])C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C(N([H])C([H])([H])[H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(O[C@]([H])(C2=NN=C3C([H])=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H]
[H]C1=C(N2C([H])=C(N=C2S1)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C(=C(F)C([H])=C1F)C([H])([H])OC1=C(Br)C(=O)N(C(=C1[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
Cc1cnc(Nc2cccc(F)c2C)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]OC(=O)C1=C([H])N2C3=C(OC([H])([H])[C@]2([H])C([H])([H])[H])C(N([H])C([H])([H])C([H])([H])C([H])([H])N2N=C([H])C([H])=C2[H])=C(F)C(N([H])[H])=C3C1=O
[H]OC1=C([H])C(OC([H])([H])[H])=C(C([H])=C1C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C(OC2=C([H])C([H])=C([H])C(=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(SC([H])([H])C2=NN=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)N(C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(OC([H])([H])C2=NC([H])([H])C([H])([H])N2[H])=C(C([H])=C1Cl)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C2=C([H])C(Cl)=C(N([H])[H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC(=O)C1=C([H])N([H])C(=O)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1SC([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[C@]23C(=O)C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])C3(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(=N1)N([H])[H]
[H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])C1=NN2C3=C(C([H])=C(N=C13)C([H])([H])[H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[H])C2([H])[H]
[H]OC(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@](O[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=NC4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C(F)C(F)=C(F)C(F)=C2F)C([H])([H])C1([H])[H]
[H]OC1=C2O[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C([H])([H])[C@]3(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]2([H])C([H])=C([H])C([H])([H])[C@@]12[H]
[H]N([H])C(=O)[C@@]1([H])N(C2=NC(=NC(=N2)N(C([H])([H])[H])C([H])([H])[H])N([H])C2=NC([H])([H])C3=C2C([H])([H])N(C(=O)N([H])[C@@]2([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])O1
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
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[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1
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[H]C1=C([H])C(=C([H])C([H])=C1O[C@@]1([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(OC([H])([H])[H])O[C@@]21C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]OC(=O)C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N([H])C3=C([H])C([H])=C([H])C([H])=N3)=C([H])C([H])=C2C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1F)C(=O)C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2S1
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[H]OC(=O)C([H])([H])C([H])([H])N1C(=O)C([H])([H])N([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])=C2[H])C1([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C([H])=O)C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2F)=CC(=C1)C(=O)NC1=NC=C(C=C1)C(O)=O
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[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(N=C23)N([H])\N=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C(N([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N1C(=NC2=C1C(=O)N(C1=NC3(C([H])([H])N21)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C([H])=C([H])C2=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]12[H])C([H])([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H]
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CS(=O)(=O)C1(CCNCC1)C1=CC(=NC(=N1)C1=CC=CC2=C1C=CN2)N1CCOCC1
[H]OC(=O)C([H])([H])[C@]([H])(C(=O)O[H])C1=C([H])C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(F)=C1[H]
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[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C1=NC(=NC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H]
[H]\C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1\C(=O)\C(=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
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[H]C1=C(C(=O)N(C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)[C@@]4([H])N(C(=O)C3([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[C@]([H])(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C([H])=C([H])C(=O)N([H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C(Br)=C(F)C([H])=C2[H])C([H])=N1
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[H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])[C@@]3([H])N(C(=O)O[C@]([H])(C([H])([H])[H])C(F)(F)F)C([H])([H])[C@]2([H])C3([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])F
[H]N(C(=O)[C@@]1([H])OC(=O)N([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]OC([H])([H])[C@]([H])(O[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C2SN=C(\N=C(/[H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(OC2=C(F)C(=C(F)C(OC3=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C3[H])=N2)C([H])([H])[H])=C1[H]
ClC1=CC(CNC2=NC=C(C(=O)NCCCN3CCCC3=O)C(NC3CCCC3)=N2)=C(Cl)C=C1
[H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H]
[H]N1C(=O)[C@]2(N(C(=O)[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C1=C(SC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]OC([H])([H])[C@@](N([H])[H])(C([H])([H])OP(=O)(O[H])O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1Cl)C1=C([H])C([H])=C(SC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1F
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])[C@]([H])(O[H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])[C@]([H])(O[H])[C@]12C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@@](O[H])(C#C[H])[C@@]2(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=C([H])C([H])=NC(OC3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])=N2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N=C([H])C(=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)=C(SC2=C(F)C(F)=C([H])C(F)=C2F)C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2N=C1[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]C1=C([H])C(=C([H])C2=NC(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C(C#N)=C([H])C(C#N)=C1[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C2=C1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])=C2C([H])=C([H])C([H])=C(N12)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C(N(C2=NC(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(\SC1=C([H])C([H])=C(Cl)C([H])=C1[H])=C(\C#N)/C(/C#N)=C(/SC1=C([H])C([H])=C(Cl)C([H])=C1[H])N([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[C@]1([H])C([H])([H])O[C@@]([H])(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N=C(N2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C([H])=C(S1)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C(F)(F)F
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[H]OC([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C2=C1C1=C(C3=C(C([H])=C([H])N3C([H])([H])[H])C([H])=C1[H])C1=C2C(=O)N([H])C1=O
[H]N(C1=C(OC([H])([H])[H])N=C(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])OC2=C(C([H])=C(Cl)C([H])=C2Br)C(=O)C1([H])[H]
[H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N1C([H])=C([H])C2=C3N(C(=NC3=C([H])N=C12)C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1(F)F
[H]N(C(=O)C1=C([H])C([H])=C([H])N1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C(C(=O)C([H])=C(O1)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])N=C12)C1=C([H])N=C(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=NOC(=N3)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1(C2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)[C@]2([H])OC3=C(C([H])=C([H])C([H])=C3N([H])S(=O)(=O)C([H])([H])[H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C(C2=NC([H])=C([H])N2C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])=C(O2)C1=C([H])C([H])=C([H])C([H])=C1O[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C#N)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(\C([H])=C(/[H])C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C(=O)C(=O)C2=C3C(=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]2([H])OC(=O)[C@@]3([H])N(C(=O)C(=O)[C@]4(O[H])O[C@@]([H])(C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])[H])C([H])([H])[C@]([H])(C4=C5N([H])C([H])=C(C5=C([H])C([H])=C4[H])C([H])([H])[H])\C(=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C([H])\[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)[C@]([H])(OC([H])([H])[H])[C@]([H])(O[H])\C(=C([H])\[C@]([H])(C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]C1=NC(=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=O)N(C1=O)C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])=C([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1[C@@]([H])(N1C(=O)N(C(=O)[C@@]1([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C([H])C(N([H])C(=N/C([H])([H])C6=C([H])C([H])=C(Cl)C([H])=C6[H])\N([H])[H])=C([H])C([H])=C5N4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(N([H])C(=O)C3=NC(C#N)=C([H])N3[H])C(=C2[H])C2=C([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]1([H])OC([H])([H])C(=O)N([H])C2=C(SC([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H]
[H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])N=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O\N=C(/N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=C2C(=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C(S1)C1=NN=C2S\C(=C(\[H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C(=NN12)C1=C([H])C(F)=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]N(C1=NC(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
OC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)C1=NC2=CC(Cl)=C(C=C2O1)C1=CC=C(Cl)C=C1
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(SC([H])([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])N(N=N1)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C2N=C([H])C([H])=C([H])N2N=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C2=NC(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(C#N)=C1[H]
[H]\C(=C1/C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(C(C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H])=C(C([H])=C1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=NN=C1Cl)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(OC([H])([H])C([H])([H])C2=C3S[C@]([H])(C([H])([H])[H])C([H])([H])C4=C3C(=C([H])C([H])=C4OC([H])([H])C3=NC([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C([H])C(Cl)=C1[H]
[H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])N=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C(OC(=C1[H])C([H])([H])SC(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C(C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H]
[H]N(C(=S)N([H])C1=NC(C(=O)OC([H])([H])[H])=C(S1)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])S1
[H]N1C(=O)OC(C2=C([H])C(=C([H])C(F)=C12)C1=C([H])C(C#N)=C([H])C(F)=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])O\N=C(/C([H])([H])N(C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])=C([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])N1N=C([H])C(=C([H])C1=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=C1N=C(C([H])=N2)C1=C([H])C([H])=C([H])S1
[H]C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C([H])([H])C([H])([H])N2C3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@@]([H])(N2C(=NC4=C2C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C3([H])[H])C([H])([H])C1([H])[H]
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[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])S1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[N@@]2C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])C([H])([H])OC([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])OC(=O)C(\[H])=C(/[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])=C1[H]
CN(CC(=O)N[C@@H](CCCCN)B(O)O)C(=O)C1=C(SC2=CC=CC=C2)C=CC=C1
[H]SC([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C(=C2[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3S2)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=NC([H])=C([H])S1
[H]O[C@@]([H])(N([H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])N=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3SC([H])([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C(Br)C([H])=C(C([H])=C1Br)C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
ON(=O)C1=CC=C(COC(=O)N(CC=C)C2CCN(C[C@H]3CN(C[C@]3(O)C3=CC=CC=C3)C(=O)C3CCCC3)CC2)C=C1
[H]C1=C([H])C([H])=C2C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C(SC2=C1[H])C([H])=C([H])C(Cl)=C3[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])N(C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C#CC([H])([H])N(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])C2=C(N=C(N=C2C([H])([H])C1([H])[H])N([H])[H])N([H])[H]
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[H]C1=C([H])C([H])=C2C(=C1[H])N(C(=C2C(=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(OC(=O)C([H])([H])C([H])([H])C([O-])=O)C1=C([H])C([H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C(=O)C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])[C@]1([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=C([H])N1C([H])([H])[H])[C@]1(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])O1)C(=O)C1=C([H])C([H])=C(O1)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C([H])O1
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])C2=NN=NN2C([H])([H])[H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C2C(=C1[H])C(=O)[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C21
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
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[H]OS(=O)(=O)C([H])([H])C([H])([H])C([H])([H])N1\C(SC2=C([H])C([H])=C([H])C([H])=C12)=C1\SC(=S)N(N([H])[H])C1=O
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])[H]
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[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
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[H]C([H])=C([H])C(=O)N([H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=N1
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[H]N(\N=C1\C2=C(N([H])C3=C2C([H])=C(F)C([H])=C3[H])C(=O)N([H])C([H])([H])C1([H])[H])C1=C(Cl)N=C([H])C([H])=C1[H]
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[H]N(C1=NC([H])=C2N(C(=O)N(C2=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C(C#N)C([H])=C([H])C([H])=C1[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C(C(=O)SC([H])([H])C([H])([H])C([H])([H])F)C(=C1C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N(C1=NC2=C(S1)C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C(C([H])=C1[H])C1=C([H])OC([H])=C1[H]
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[H]N(C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC([H])([H])C1=C([H])N=C(N1C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2C1=C([H])C([H])=C([H])C([H])=C1C([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]N(C(=O)C1=NOC(=C1[H])C([H])([H])[H])C1=C2C(=C([H])C([H])=C1[H])C1=NN([H])C(C3=C([H])SC([H])=C3[H])=C1C2([H])[H]
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[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=C(\F)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])\C([H])([H])SC([H])([H])C([H])([H])[H]
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[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C(I)=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2F)C1=O)[C@]1([H])C([H])=C([H])S(=O)(=O)C1([H])[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(C1=C([H])C([H])=C(O[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C2=C1N=C(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN(C(=O)N21)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)\C(=C2/N([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C2=C1C([H])=C([H])C(=C2[H])C([H])([H])[H]
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[H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(=C1[H])[C@@]1([H])SC(=NN1C(=O)C1=C(F)C([H])=C(OC([H])([H])[H])C([H])=C1F)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N=C(N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2C#N)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N=[N+]=[N-])C([H])=C1[H]
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[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C(OC2=C(F)C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1([H])N(C([S-])=S)C([H])([H])C([H])([H])N(C([S-])=S)C1([H])[H]
[H]C1([H])N(C2=NN=C(S2)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(=O)C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[S+]([O-])(=NC(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N([H])[C@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NC2=C(S1)N=C([H])N=C2OC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N=C(N([H])[H])N([H])C(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC(=O)C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC(=C1[H])C1=C([H])C([H])([H])C([H])([H])C2=C1SC([H])=C2[H]
[H]S[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]OC1=C([H])C([H])=C([H])C(O[H])=C1C1=NC(N([H])[H])=C(C#N)C(=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)C(=O)N([H])C([H])([H])[C@]([H])(SC([H])([H])C([H])([H])[H])C([H])([H])[H]
CC(C)(C)C1=CC=C(OC(=O)N2CCC3=C(C2)NC2=C3C=C(O)C=C2)C=C1
[H]OC([H])([H])C1=NN(C(=C1C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C([H])N=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N([H])C(=O)C1=C(N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])[H])C1([H])[H])N([H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3OC4=C(C([H])=C(O[H])C([H])=C4[H])C3=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H])C1=C([H])N=C(S1)C([H])([H])[H]
[H]OC1=C(C([H])=C(OC([H])([H])[H])C([H])=C1OC1=C(F)C(=C(F)C(OC2=C([H])C(=C([H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])=N1)C([H])([H])[H])C(=N[H])N([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[N@@+]23C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]([H])(OC(=O)[C@](N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C3([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1([H])C([H])([H])N(C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(C(=O)N([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(SC2=C3C([H])([H])C([H])([H])[C@@]4([H])[C@]5([H])C([H])([H])C([H])([H])C(=O)[C@]5(C([H])([H])[H])C([H])([H])C([H])([H])[C@]4([H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])C2=O)C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])N(C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
CN1C=C(C2=NC3=C(O2)C=C(CC(=O)N2C[C@@H](F)C[C@H]2CO[C@H]2CC[C@@H](CC2)C(O)=O)C=C3)C2=C1C=C(F)C=C2
[H]N([H])[C@]1([H])C([H])([H])N(C2=NC(C(=O)N([H])C([H])([H])[H])=C(N2C([H])([H])C2=C(C#N)C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1N=C(C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)S(=O)(=O)N1[C@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])OC([H])([H])[C@]1([H])C1(OC(=O)N2C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H][C@]12CNCc3cccc(C(CC)c4c(O)c(O)ccc14)c23
[H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN([H])C(OC([H])([H])[H])=C1[H])C1=C([H])N=C([H])C(=N1)N([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H]
[H]OC1([H])C([H])([H])N(C2=NC(N3C([H])([H])C([H])([H])N(C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C3C([H])=C(SC3=N2)C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]