[H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C(=O)N([H])[H])C([H])([H])[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC2=C1C(=O)N(C(=O)N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C(C(=O)C2=C(O[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]([H])(C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])[C@]1([H])O[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])SC1=C([H])C([H])=C([H])S1 [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N([H])N=C1C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1[C@@]1([H])N(C(=O)C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])[C@@]1(C(=O)OC([H])([H])C([H])([H])[H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=NC(=C([H])N=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C([H])([H])C1=C([H])SC(=N1)C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N2C(=O)N(N=C12)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C12 [H]N(C([H])([H])C([H])([H])OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C(N(N=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] COC1=C(C=CC(NC(=O)C=C)=C1)S(=O)(=O)N1CCN(CC1)C(=O)OC(C)(C)C [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([3H])([3H])[3H])C([H])([H])C([H])([H])C1=C(OC([3H])([3H])[3H])C([H])=C(I)C(OC([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=C(N([H])[C@]2([H])C3=C(OC([H])=C3C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C(=C([H])C([H])=C2N=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C(Cl)C([H])=C1N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C(=O)N([H])C([H])([H])C2=C(C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])=C2[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] NS(=O)(=O)C1=CC(=CC=C1)S(N)(=O)=O [H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C2C([H])=C([H])C([H])=C3F)C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(F)=C(N([H])C([H])([H])[H])C([H])=C2N2C([H])=NC([H])=C12)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C3=C([H])C([H])=C([H])N3[H])C2=C1[H] [H]N([H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC1=C([H])C([H])=C2C(=O)N(C(=O)C2=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(C2=C(N(C1=O)C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C(O2)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N([H])C1=NC(=C([H])N1[H])[C@@]1([H])C2=C(N([H])C(Br)=C2Br)C(=O)N([H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2SC2=C([H])C([H])=C(C([H])=C2C(F)(F)F)[C@@]2([H])C([H])([H])[C@]2([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C([H])C(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])[C@@]1([H])SC([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(Br)=C(OC([H])([H])C2=C(F)C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N1C2=C(N=C1C([H])([H])C([H])([H])N1N=C(Cl)C([H])([H])C([H])([H])C1=O)C(=O)[C@@]([H])(C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]\C(=C(\C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])ON=C3C4=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C4OC([H])([H])[C@@]23[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(OC([H])([H])[C@]4([H])OC(=O)C(=C([H])[H])C4([H])[H])C([H])([H])C([H])([H])[C@@]4(OC(=O)C([H])([H])[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]O\C(=N/C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C1=C([H])C2=C(SC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C1=O [H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C(=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]C1=C([H])C(Cl)=C([H])N2C1=NC(=C2C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(\N=C(/[H])C1=C([H])C(Br)=C(Br)O1)C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1 [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])N2N=C([H])C(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=NC([H])=C2S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C(SC([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N([H])C1=NC([H])=NC2=C1C(=NN2C([H])(C([H])([H])[H])C([H])([H])[H])C#CC1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=C2C(=NC3=C1C([H])=C([H])C([H])=N3)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C([H])=N3)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C3C(=O)N(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C(=O)C3=C3C4=C(C([H])=C(O[H])C([H])=C4[H])N(C3=C1N2[H])[C@@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O CC1=CC=C(OCCSC2=NC3=CC=CC=C3N2)C=C1 [H]OC1=NC(=NC2=C1N=C(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H])N([H])[H] [H]N(C1=NC2=C(N=NN2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=NN1C([H])([H])[H])C1=NN([H])C(=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])=NC3=C2[H])C([H])([H])C1([H])[H] [H]O[C@](C#CC1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])[C@]3([H])C([H])([H])OC([H])([H])C3([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C([H])C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C(=N\[C@@]2([H])C(=O)N(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])\N([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[S@](=O)C([H])([H])C([H])([H])OC(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(Cl)C([H])=C(C(=C1[H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C#CC([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C2=C(N=C(N([H])C2=O)C([H])([H])[H])C([H])=C1Br [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=NN([H])C([H])=C2C2=NC(=NC([H])=C2[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N2N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C4[C@]5([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]5(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(SC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)=NC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[N+]([O-])=O)C(=O)C([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[C@]([H])(O[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C2=NN(C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])([H])C([H])([H])N1[H] [H]OC(=O)[C@]([H])(N([H])C1=C([H])C(SC([H])([H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H] [H]N1N(C(=O)\C(=C(\[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C1=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C(=O)C(OC([H])([H])[H])=C([H])C([H])=C1[H] CCNc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(C)c1 [H]N([H])C(=O)C1=C(N=C(N([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])[H])N2C([H])=NN=C12)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])[C@]1(N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])OC1=C([H])C(=O)N(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2N=C1Cl [H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])C#N)C(=C1[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NN=NN1[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]1([H])OC2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]