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[H]N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=N3)C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@](OC([H])([H])[H])(OC1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(N([H])C2=C([H])C(=O)C(=O)C3=C2C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(O[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]OC1=C(F)C(=C([H])C([H])=C1[H])C1=C([H])N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1C(F)(F)F
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]OC(=O)C(OC([H])([H])C1=NN(N=N1)C([H])([H])C([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(Cl)=C([H])C([H])=C2N2C([H])=C([H])C([H])=C12)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
CCC1=NC2=C(N1[C@H]1CCC3=C1C=CC(=C3)C1=CC=CC=C1C1=NN=NN1)C(=O)N(CC1CCCCC1)C=C2
[H]N1C(=O)N([H])[C@@](C#CC2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])(C1=O)C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])\C(=N\OC(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C2=NC(=C([H])C([H])=C2C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C([H])([H])[C@]3(C3=C([H])C([H])=C(Br)C([H])=C3[H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])[H])=C1[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C(F)(F)F)C(F)(F)F
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])[N+]([O-])=O
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3(OC([H])([H])C([H])([H])O3)C([H])([H])C2([H])[H])C2=NN(C(=O)N12)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC1=C(C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=NC(N([H])[H])=C(C#N)C(=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C(C([H])=C3O[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(F)=C1[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])N([H])C(=O)C([H])([H])C2([H])[H])=C1C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NSN=C1[H]
[H]N([H])C(=N/OC(=O)N1C2=C([H])C([H])=C([H])C([H])=C2SC2=C([H])C([H])=C([H])C([H])=C12)\C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C([O-])=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])O[C@@]1([H])C([H])([H])N2C(=O)N(C(=O)[C@]2([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C2N([H])C([H])=NC2=C([H])C(Br)=C1[H])[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=C([H])C([H])=C([H])C(N([H])C3=NC([H])=C(S3)C3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])[H])C([H])([H])[H]
[H]C1([H])C(Br)=NO[C@]11C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C2C(=NC([H])=N1)N(N=C2C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])N=C(S2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NN=C(\C1=N/N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N(C(=C1C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])N([H])C([H])([H])[C@@](O[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
CCN(CC)C(=O)CC1=C2N=C(C)C(CC)=C(C)N2N=C1C1=CC=C(OCCF)C=C1
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H]
[H]N1C(=O)N([H])C2=C(C1=O)C(=C([H])C(=O)O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N1N=C(C([H])=C(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C(C([H])=C(C2=C1OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])=C(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])=C([C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])[C@@]1([H])OC(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=N1)N1C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C1C([H])=C(O[H])C([H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])\C(=N\C2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=NC([H])=N2)C(=O)C([H])=C1C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C2=C1N=C(O2)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=C([H])N=C1[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=N2)[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2F)C([H])([H])N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C2N=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2N=N1
[H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O\N=C1/C(=O)N(C2=C([H])C(=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C2OC([H])([H])OC([H])([H])C2=C([H])C(F)=C1[H]
[H]N(C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
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[H]C1=C([H])C(=C([H])C(=C1[H])C1=NN=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C2OC([H])([H])C([H])([H])N(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H]
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[H]ON(C([H])=O)[C@@]([H])(C([H])([H])N1C(=O)N([H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C(=O)N([H])N=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C(O[H])C([H])=C1Cl
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C(=C(C#N)C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C([H])SC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])F
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC1=C(C#N)C(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])([H])C([H])([H])C2=C1C([H])=C([H])S2
[H]N1C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H]
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[H]C1=C([H])C2=C([H])C([H])=C3C([H])=C(C#CC([H])([H])[H])C([H])=C([H])C3=C2C([H])=C1[H]
[H]OC(=O)C1=NN([H])C(=C1F)C1([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=NN1C1=C([H])C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=C1[H])C([H])([H])[H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
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[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
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[H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])=C([H])C1=NC2=C(C(=NN2C2=C(Cl)C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C([H])([H])[H])C(=O)N1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=NC([H])=C([H])S1
[H]OC([H])([H])[C@@]1([H])S[C@@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C(C#N)=C1[H])C(=O)N([H])[C@]([H])(C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(F)=C1N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C2C(C(=O)N(C([H])([H])OC3=C([H])C(=O)OC(=C3[H])C([H])([H])[H])S2(=O)=O)=C(C([H])=C1OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])[C@]4(OC(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])[C@@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(N=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(F)=C([H])C([H])=C3F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC(C2=C([H])C([H])=C(Br)C([H])=C2[H])=C1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(N=C([H])C([H])=C2N1[H])C1=C([H])C(Br)=C(Br)N1[H]
[H]OC1=C([H])C([H])=C2C(OC(=O)C([H])=C2C([H])([H])SC2=NN=C([H])S2)=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C(SC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])N=C23)N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])OC(=O)C(=C21)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])[H])C([H])([H])O[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]C1=C([H])C(=C([H])C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@@](C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C([H])S2)C2=C([H])C([H])=C(F)C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Cl)=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@]2([H])SC([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)O[C@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C(OC(=N2)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C4=C3OC(F)(F)O4)C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C(F)C(F)=C12)C([H])([H])N1C2=NC([H])=C([H])C([H])=C2N=C1C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C3=C([H])C(F)=C([H])N=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C2N=NN(C2=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C([H])C2=C1N=C([H])N=C2N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
COC1=CC=C(C=C1)N1CCN(CC1)C(=O)CNC(=O)CN1CCC2=C3C1CNC(=O)C3=CC=C2
[H]OC1=C2N=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]SC1=NN=C(N1N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl
[H]N1C([H])=C(C([H])=O)C2=C1C([H])=C([H])C1=C2C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])([H])C([H])([H])C([H])([H])N2[H])C1([H])[H]
[H]N1C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C1C(=NC([H])=N2)N1C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(SC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=O)C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C#N)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C(N([H])C(=O)C([H])([H])[N+]2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C(F)(F)F)S(=O)(=O)N([H])[H]
[H]N(C1=C(SC2=NC(SC([H])([H])[H])=C([H])S2)C([H])=C2C(=O)OC([H])([H])C2=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC([H])([H])[C@]12O[C@@]1([H])[C@@]1([H])[C@@]3([H])O[C@@]4(O[C@@]5([H])[C@@]([H])(C([H])([H])[H])[C@]1(O4)[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@]([H])(OC(=O)\C([H])=C(/[H])\C(\[H])=C([H])\[C@]([H])(OC(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@](O[H])(C([H])([H])[H])[C@@]35O[H])[C@]4([H])C([H])([H])[H])[C@@]1(O[H])[C@]2([H])O[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2C(=NC3=C(C(=NN13)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC1=C(O[H])N=C2C(=N1)C([H])=C(Br)C1=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N=C([H])N=C1OC([H])([H])C([H])([H])OC1=NC([H])=C(SC([H])([H])[H])C([H])=N1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC(=N1)C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])N=C(S1)[C@@]1(OC([H])([H])[H])C2=C(C([H])=C([H])C(OC([H])([H])C3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H]
CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NN(CCCS(C)(=O)=O)C2=C1C=C(OC(F)F)C=C2
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]C1=C([H])C(O[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C2=C1C1=C([H])C([H])=C(O[C@@]3([H])C([H])([H])[C@@]4([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C4([H])[H])C3([H])[H])C([H])=C1C2=O
[H][N+]([H])([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C2OC([H])([H])C(=O)N([H])C2=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(\N1N=C([H])C([H])=C1[H])=C(\F)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H]
[H]SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NC(=C(C(=O)N1C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C(N=C(N1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4[H])C([H])=C([H])C(=C5[H])C([H])([H])N([H])C(=N[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
CN1C=C(C=N1)C1=CC(F)=C(CN2C(=O)CC3=CC=CC=C23)C=C1
[H]OC(=O)C([H])([H])N(C(=O)C1=C([H])C(N([H])C(=O)N([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H]
[H]C1=C([H])C(C#N)=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(N([H])S(=O)(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NOC([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(SC2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(F)(F)F
[H]N(C1=C2N=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=NON=C12
[H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C#N)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N=NC(=N1)C([H])([H])N1C(=O)N(C(=O)C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C(N1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])([H])[H])C([H])([H])N(O1)C1([H])C([H])([H])C([H])([H])N(C(=O)N2OC(=O)C(=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
NCC1=CN(N=N1)C1=CC=CC=C1
[H]N1C(=O)\C(=C(\[H])C2=C(C([H])=C(N2[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12
[H]C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C2C([H])=C([H])N(C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1N=C(N=C1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])OC([H])([H])C([H])([H])F)C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]OC1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1N=C(\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C([H])C(Br)=C23)C([H])([H])[H])C1=O)C1=NC([H])=C([H])N=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])S1
[H]N1C(=O)C2=C(SN=C2C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N=C1C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N([H])C2=O
[H]N(C(=O)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1N=C([H])C([H])=C1[H])N1N=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C(F)C([H])=C2[H])C(Cl)=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=NN=C(N2C([H])([H])C1([H])[H])C([H])([H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])[C@@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])[C@]([H])(C2=C(F)C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])C3=NC4=C(C([H])=N3)C([H])=C([H])C(=O)N4C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([C@]([H])(C1=NC([H])([H])[C@]([H])(N1[H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H]
[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[NH3+][Ru]([NH3+])([NH3+])([NH3+])([NH3+])O[Ru]([NH3+])([NH3+])([NH3+])([NH3+])O[Ru]([NH3+])([NH3+])([NH3+])([NH3+])[NH3+]
[H]O[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C(=C2[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C1=NN([H])N=N1)C(=O)N([H])[H]
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(I)C([H])=C4[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])N2C(=O)N(C(=O)[C@]12[H])C1=C(F)C(F)=C(C#N)C([H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])=C2C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
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[H][C@@]1(CCCCN1C)[C@H](C(=O)OC)C1=CC(CO)=C(OCO)C=C1
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[H]OC1=C(N=C(C(=N1)C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])[H])=N1
[H]N1C(=O)ON(C1=O)C([H])([H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C(=N[H])N([H])[H]
[H]\C(=N/OC([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])C([H])=C([H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])C([H])=C(S2)C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@@]([H])(OC([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2C(=O)C3=C(C([H])=C(C([H])=C3[H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])S(=O)(=O)C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(N([H])C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C2[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C12)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])O1
[H]C1=C([H])C(=C2C(=O)N(C3=C([H])C([H])=C(OC4([H])C([H])([H])C([H])([H])N(C([H])([H])C4([H])[H])C4([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2\C([H])=C(/[H])C(=O)N1N=C(C2=C1C([H])([H])[C@]1([H])[C@@]2([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC(OC([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C3N=C([H])N([H])C3=N2)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=NC([H])=C2Cl)C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])ON=C1C([H])([H])[H]
COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(N=C3)C3=CCN=C3)C2=O)C=C1
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])SC([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])N([H])[C@@]([H])(C(=O)O[H])C([H])([H])O[H])C([H])([H])O[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1N2C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N=C=S)[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H]
OCC1=CC=CC(=N1)C#CC1=CC(F)=CC(=C1)C#N
[H]OC1(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])([S@@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])N=C(SC([H])([H])[H])N=N1
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C(F)C(F)=C12)C([H])([H])N(C1=C([H])C([H])=NC([H])=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)N(C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])C#N)(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(CO)C(Cl)=C1C
[H]N1C([H])=C(N=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]ON([H])C(=O)C1=C([H])C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2S1
[H]OC(=O)C1=C([H])C(C2=C3C([H])=C([H])C(=NC3=NN2[H])N([H])C2=C(F)C([H])=C(F)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C([H])=C(C([H])([H])N(C([H])=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])[C@@]2([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(OC(=O)C([H])=C2C([H])([H])C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])N=C1C([H])(F)F
[H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(O1)C(=O)OC1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)O2)C([H])([H])[H]
[H]N1C(=O)N([H])C2(C3=C([H])C(Cl)=C(Cl)C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1C(=NC2=C(SC(=C12)C([H])([H])[H])C([H])([H])[H])[S@](=O)C([H])([H])C1=NC([H])=C([H])C(OC([H])([H])C(F)(F)F)=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C(N=C(N([H])C([H])([H])C2=NON=C2C([H])([H])[H])C1=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1OC(C1=C([H])C([H])=C([H])C([H])=C1[H])=C(C2=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C2O[C@@]3([H])C4=C(C5=C([H])C(N([H])C(=N/C([H])([H])C6=C([H])C([H])=C(N([H])[H])C([H])=C6[H])\N([H])[H])=C([H])C([H])=C5N4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N([H])C1=C2C(=NC3=NC(OC([H])([H])[H])=C(C#N)C(C4=C([H])C([H])=C([H])C([H])=C4[H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C(OC2=NC(OC3=C([H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C(F)C(N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2F)C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
OB1OCC2=CC(OC3=CC=C(C=C3)C#N)=CC=C12
[H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C(C(F)=C([H])C([H])=C2O1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@]1([H])[C@]([H])(O[C@@]([H])(C([H])([H])O[P@@](=O)(O[H])C(F)(F)[P@](=O)(O[H])OC([H])([H])[C@@]2([H])O[C@@]([H])(C3=NC(=C([H])S3)C(=O)N([H])[H])[C@]([H])(O[H])[C@]2([H])O[H])[C@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])C([H])([H])[C@@](C1=O)(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=O)C(=O)C3=C([H])C(OC(F)(F)F)=C([H])C([H])=C23)C([H])=C1[H]
[H]N(C1=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NC(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C(C(=N1)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(SC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C2=C(C3=C(S2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(=O)N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C(Cl)=C(N([H])C([H])([H])C([H])([H])C([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C([H])C2=N1
[H]N(\N=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]OC1=C(OC([H])=C([H])C1=S)C(=S)N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C2([H])[H])=NC(N([H])[H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C2C(=C1[H])N(C([H])=C2C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
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[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN(C2=C1N=C(C1=C([H])C([H])=C(C([H])=C1[H])N1C(=NC3=C1C([H])=C([H])N=C3[H])C([H])([H])[H])C([H])([H])C(=O)N2C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C3=C([H])C([H])=C([H])C(=C3[H])[C@@]([H])(N(C(=O)C([H])([H])[H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C2=N1)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])[C@]2(C1=O)C(=O)N(C(=O)C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1Cl)C1=C([H])C(C#N)=C([H])C(=C1[H])C([H])([H])N1N=C([H])N=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2C#N)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C3=NSN=C3C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N([H])C1=C([H])C(Cl)=C(F)C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])SC(=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])OC(=O)C1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=C(C#N)C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N1C(=O)O[C@@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C2=NOC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2=C([H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H]
[H]N=C1N(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
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[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
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[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=C([H])C2=C(C([H])=NN2[H])C([H])=C1[H]
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[H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(C([H])=NN1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C2=NC(=C([H])N2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N(N=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=O)C([H])([H])S1
[H]C1=NC(=C(O1)C1=C([H])N2C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN=C2C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
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[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])C3=C(C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
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[H]N(C(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C(=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N=C(O1)C([H])([H])N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C4=C(N=C2C([H])([H])[H])C([H])=C([H])C([H])=C4[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C([H])([H])[H])N2N=NN=C2C(F)(F)F)[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=N\N=C(/[H])C([H])([H])C([H])([H])OC1=C([H])C(OC([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)=C([H])C(=C1[H])C([H])([H])[H])N([H])[H]
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[H]O[C@@]1([H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])[C@]2(N3C([H])([H])C([H])([H])[C@@]([H])(C3([H])[H])C2([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C(=O)N(OC([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/C([H])([H])[H])[C@@]2([H])OC(=O)[C@@]3([H])N(C(=O)C(=O)[C@]4(O[H])O[C@@]([H])([C@@]([H])(OC([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])[H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])\C(=C([H])\[C@]([H])(C(=O)C([H])([H])[C@]([H])(O[H])[C@@]2([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])[H]
[H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C(C([H])=C(F)C([H])=C3[H])S(=O)(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H]
[H]N(C(=O)[C@]([H])(N(C(=O)C([H])([H])Cl)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(Br)C(Br)=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H]
[H]N(C1=C(C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC([H])=N1)C1=C([H])C([H])=C(Br)C([H])=C1[H])S(=O)(=O)N([H])C1([H])C([H])([H])C1([H])[H]
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2SC3=C(C([H])=C([H])C([H])=C3[H])C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
CC1=CC(=CC=C1F)C(=O)NCCCC[C@@H](NC1=CC(C)=C(F)C(C)=C1)C(=O)NO
[H]C1=C([H])C([H])=C2C([H])=NC(=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=NN=NN1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C4C(=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])S2(=O)=O)C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3C(F)(F)F)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]\C(=C(\[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])[C@]12C([H])([H])[C@@]1([H])[C@@]([H])(N1C([H])=NC3=C1N=C(Cl)N=C3N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H])[C@]1([H])O[C@]21[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1O[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C(=C([H])C(OS(=O)(=O)C3=C([H])C([H])=C([H])C([H])=C3Cl)=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)\C2=C(\[H])C2=C([H])C([H])=C([H])N2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])N(C#N)C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC1(C(=O)O[C@@]2([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
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[H]N([H])S(=O)(=O)C1=C([H])C2=C(N([H])C(=O)\C2=C(\[H])C2=C([H])N(C3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C(=NC2=C1C([H])=C(C([H])=C2[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(Br)O1
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(C([H])=C2Cl)C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(Br)C([H])=C12)C1=C([H])C([H])=C([H])C(Br)=C1[H]
COC(=O)C1=CC=C2N\C(\C(=N\O)\C2=C1)=C1/C(=O)NC2=C1C=CC=C2
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1(OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C([H])C2=C1N=C([H])N([H])C2=O
[H]N(C1=NC(=NC(Cl)=C1SC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)=NC2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C([H])=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])S2(=O)=O
[H]OC1=C2O[C@@]3([H])C4=C(C([H])=C(C([H])=N4)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
O=C(NC1=C(N=CC=C1)C(=O)NCC1CCC1)C1=C2N=CC=CC2=CC=C1
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])N=C(N(C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1I)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC2=C(O[C@]([H])(C([H])([H])[H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C([H])C(O[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1Cl
[H]OP(=O)(O[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2N(C(=O)C([H])([H])F)C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[H])C([H])=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C([H])C([H])=C([H])C([H])=C2F)S1(=O)=O
[H]N(C1=NN2C([H])=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])N(C2=C1C(=C([H])C(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H]
[H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(Br)=C([H])N2C1=NC(=C2C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])=N1
[H]N(C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C2C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C1=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=NN([H])N=N2)C([H])=C(N=C1C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N(C(=O)C1=C([H])C2=C(N([H])C(=C2C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=O)N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])N3C([H])=C([H])C([H])=C3C2([H])[H])C(Cl)=C1[H]
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[H]N([H])C1=C2C(=NC3=C1[C@@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C(C(=O)OC([H])([H])C([H])([H])[H])=C(N3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]C([H])=C([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]OC(=O)C1=C([H])C([H])=C2C3=NN(C4=C([H])C([H])=C(C#N)C(=C4[H])C([H])([H])[H])[C@]([H])([C@@]3([H])C([H])([H])C([H])([H])C2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(N([H])C([H])([H])C([H])([H])[H])=C(C([H])=C23)[N+]([O-])=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@](C#N)(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F
[H]ON([H])C(=O)[C@@](O[H])(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(N=C(S2)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=NO1)C1=NSN=C1N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NOC(=N1)C([H])([H])[H]
[H]OC(=O)C(OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=NS2)C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O
CC(OC1=C(Cl)C=C(Cl)C=C1)C(=O)NC1=CC=C2OC(=NC2=C1)C1=CN=CC=C1
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[H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H]
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[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])[C@@]2([H])SC([H])([H])C([H])([H])\N=C(/S[H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C(=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C2=O
[H]N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=O)=C1[H]
[H]C1=C(C(=O)C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])N2C(=C1[H])C(=NC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C(F)C(F)=C([H])C(F)=C1F)C2([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=C(OC([H])([H])[H])N=C(N=C1C([H])([H])[H])C1=C(C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C2=C([H])C(Cl)=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=N3)C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(S1)C1=NN=C(SC([H])([H])C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])N1C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])O[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C(OC(F)(F)F)C([H])=C([H])C(=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=NC(=NC([H])=C3C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(N(C(=N1)N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C(=O)N2C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C(C(=O)N([H])C1=NN=C([H])S1)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[P@](=O)(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NC(=C([H])O1)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])N2C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C(F)(F)C2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])N1C([H])=C(C(=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=NC(=C1[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=C2[H])[N+]([O-])=O)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C2=C1OC(=N2)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)O1)C([H])([H])[H]
OC1=C(SC2=CC=CC=N2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])[N+]([O-])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C(OC([H])([H])[H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])ON1C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1=O)C([H])([H])O2
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1[H])C(=N[H])N([H])[H]
[H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])C1=C2N=C(N=C(N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2=NN1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])SC(SC([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])[C@]2([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=NC3=C(S2)C([H])=C([H])C(Cl)=C3[H])=N1
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])N(C2=C1C([H])=C1C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=N\OC([H])([H])[H])\C1=NC2=C(O1)C([H])=C([H])C([H])=N2
[H]N1C2=NC(N([H])C3=C([H])C(=C([H])C([H])=C3N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])\C([H])=C([H])/C3=C(C([H])=C(OC([H])([H])[H])C1=C3[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C(Cl)C([H])=N2
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
COC(=O)C(N1C(C2=CC=C(Cl)C=C2)C(=S)NC2=CC(Cl)=CC=C2C1=O)C1=CC=C(Cl)C=C1
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[H]OC1(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]O[C@@]1([H])C2=C(N([H])C([H])=NC1([H])[H])N(C([H])=N2)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(N([H])C(=N3)C3=C([H])C(=C([H])S3)C3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C1=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1N=NN=C1C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])C1=NOC(=N1)[C@]1([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=NC([H])=C([H])C([H])=C12
[H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=C([H])C(=NC2=C(C(=O)N([H])[H])C(=NN12)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N([H])C1=NC([H])=NC([H])=C1[H]
[H]N(C(=O)C1=NSN=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=C(C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(Br)=C1[H])C1=NC([H])=NC2=C1C([H])=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]