[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(\C#N)C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=NC(\C([H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C2=C([H])C([H])=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])[C@@]1(C(=O)N([H])C(=O)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C(Br)=C([H])C(Br)=C1[H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(/C2=C([H])/C3=C([H])/C(=C([H])\C4=C(C([H])=C([H])[H])C(=C(N4[H])/C([H])=C4\N=C(\C(\[H])=C\1/N\2[H])C(=C4C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)[C@@]1([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C(=C3C([H])=C([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C(=C([H])C2=C1[H])C([H])([H])N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=C1O[H])C1=C([H])C(O[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N(N=C2[H])C2=C(F)C([H])=C([H])C([H])=C2F)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1=NOC([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N=C([H])C([H])=C1[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]C([H])([H])C1=NN=C2SC(SSC3=NN4C(S3)=NN=C4C([H])([H])[H])=NN12 [H]N(C1=NC([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])N=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C([H])=N2)C([H])([H])[H] [H]N(C(=O)C1=NON=C1[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(OC([H])([H])C([H])([H])N3[C@@]4([H])C([H])=C(C5=C([H])C([H])=C6C([H])=C([H])C([H])=C([H])C6=C5[H])C([H])([H])[C@]3([H])C([H])([H])C4([H])[H])C2=N1 [H]N(C1=C([H])C(=NS1)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N(N=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] OC(C1=CC=CC=C1)(C1=CC=NC=C1)C1=CC2=C3N(CCC3=C1)C(=O)CC2 [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C12)C1=C(Cl)C([H])=C([H])C2=C1OC([H])([H])O2 [H]OC1=C([H])C([H])=C2N3C([H])=NC([H])=C3C(=NC2=C1O[H])N([H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C(C#N)C2=C(C([H])=C(C(=C2OC(=O)C(\[H])=C(/[H])C([H])([H])[H])C2=C(OC(=O)C(\[H])=C(/[H])C([H])([H])[H])C3=C(C([H])=C2C([H])([H])[H])C(=C(O[H])C(O[H])=C3C#N)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=C1O[H])C([H])(C([H])([H])[H])C([H])([H])[H] OCCC(NC(=O)NC1=CC=C(C=C1)C1=CNN=C1)C1=CC=CC(F)=C1 [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1C(F)(F)F)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1Cl [H]ON1C2=C(C(=NN2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12 [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1(N3C(=O)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])O1)C([H])([H])C([H])([H])C#N [H]O[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N=C(C1=C([H])N=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C2C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(N1C([H])([H])C([H])([H])N(C(=O)N2N=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C3=C(N=C(N=C3[H])C#N)N2C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C(Br)C([H])=C(\C([H])=C(\C#N)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])=C([H])C([H])=C1\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[N@@]2C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NN(C(=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H] [H]OC1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])[C@@]2([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C1C(=O)N(C(=O)C1([H])[H])C([H])([H])C#CC([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])N(C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]SC([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N1C(=O)C(=C([H])C2=C1C([H])=C([H])C(=C2[H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C(C2=C([H])C([H])=C([H])S2)C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C1=C([H])C(=C([H])N=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(\[H])=C(/[H])C3=C([H])C([H])=C(C([H])=N3)C3=C([H])C([H])=C([H])C(Cl)=C3[H])[C@]3([H])[C@]([H])(OC(=O)[C@]3([H])C([H])([H])[C@]2([H])C1([H])[H])C([H])([H])[H] [H]OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(Br)C([H])=C1\C([H])=C1/SC(=O)N([H])C1=O [H]OC(=O)C1=C([H])C([H])=C(C(N([H])C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]12C3=NON=C3C([H])([H])C([H])([H])C1=[N+]([O-])[C@@](N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])[H])C2([H])[H] [H]OC(=O)[C@]([H])(N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C(Br)=C([H])C([H])=C3[H])C([H])=NC([H])=C2S1 [H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1(C2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C(C([H])=C1[H])C1=C([H])OC([H])=C1[H] [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C2=C3N=C([H])N([H])C3=NC([H])=N2)C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1[H])[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C#N)C([H])([H])[C@@]2([H])N(C([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C([H])C([H])=C([H])C([H])=C3Cl)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])N2C(=C1[H])[C@@]([H])(N(C(=O)C([H])([H])N(C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] CCN(CC)C(=O)CC1=C2N=C(C)C(Cl)=C(C)N2N=C1C1=CC=C(OCCF)C=C1 [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H] [H]N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])O1)C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])O1 [H]O[C@](C([H])([H])[H])(C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]23C([H])([H])C([H])([H])[C@@]1(OC([H])([H])[H])[C@]1([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]21C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C5([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H])C(=O)N([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])[C@]([H])(C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=NC3=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3C(=O)N1C([H])([H])C2([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC([H])=C([H])N12)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC([H])=C1C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C(=S)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])N(C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(N([H])C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])=C2[H] CC(C)C[C@H](CO)NC1=NC(=NC2=C1SC(=O)N2)[S+]([O-])CC1=CC=CC=C1 [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NS2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=NC([H])=C1S(=O)(=O)N([H])[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)O[C@]([H])(C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(N([H])[H])C(Cl)=C1[H] [H]OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N=C([H])C2=C1N=C(N([H])[H])N1N=C(N=C21)C1=C([H])C([H])=C([H])O1 [H]O[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2(O[H])C(=O)C([H])([H])SC([H])([H])C([H])([H])N([H])C(=S)N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])C3=C([H])C(=O)C([H])=C([H])[C@]3(C([H])([H])[H])[C@@]12F [H]N([H])C(=O)C1=C(N([H])C2=C([H])C(F)=C(F)C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H] [H]C1=C([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])=C2N=C(C([H])=NC2=C1[H])C1=C([H])C(=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])[C@]2([H])C([H])([H])[H])=C2C(=N1)C([H])([H])C([H])([H])S(=O)(=O)C2([H])[H] [H]N(C1=C([H])C(=O)N(C(=O)N1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(=C(C#N)C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])[H])C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C([H])([H])OC([H])([H])[H])C1=C2C(=C([H])C([H])=C1[H])C1=NN([H])C(C3=C([H])SC([H])=C3[H])=C1C2([H])[H] [H]N(C(=O)C([H])([H])SC1=NN=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N1C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C2=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C(=C(N=C2C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C(N([H])C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(N([H])C(=O)C2=C([H])C3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C1=C2C(=NN1[H])C([H])=C([H])C([H])=C2OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]\C(=C1\S\C(=N\C([H])([H])C([H])([H])[H])N(C1=O)C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NN=C2N1C(=NC1=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C21)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C#N)C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C2=NC(=NO2)C([H])([H])[H])C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(N=N1)N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N1C([H])([H])[C@]2(OC([H])([H])C([H])([H])O2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C(Cl)=C1C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C2=C(C([H])=C([H])C(=C2[H])C(=N[H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C2=C(C([H])=C(Cl)C([H])=C2[H])C(=O)N([H])C2=NC([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(C([H])=C2C([H])=C3C(OC([H])([H])C([H])([H])C3([H])[H])=NC2=C1[H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])[C@@]1([H])\C([H])=C(C([H])([H])[H])\C([H])([H])C([H])([H])OC(=O)OC(=O)[C@@]2([H])O[C@](C(=O)C(=O)C(=O)OC(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])N=C3[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=O)(C([H])([H])[H])C([H])([H])C2([H])[H] [H]O[C@@]([H])(C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C(=S)N(C(=O)C2=C([H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C2N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=NC1=C2C(=NN(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]C(=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[C@]1([H])OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=O)C1([H])[H] [H]O[C@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C(F)(F)F)C1=NN([H])C2=C1C([H])([H])N(C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(/C1=C([H])C(=C([H])C(=C1OC([H])([H])C([H])([H])C([H])([H])F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H] COC1=CC(=CC(OC)=C1OC)C1=NN=C(O1)SCCN1C(C)=NC=C1[N+]([O-])=O [H]N1N=C([H])C2=C([H])C(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[C@@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C3=C(N([H])C2=O)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C3=C(C([H])=C([H])S3)[C@@]21[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CCN1CCN(CC1)C(=O)C1CCC(=O)N1C1=NC(C#C[C@]2(CN3CC4=C(C=C(OC)C=C4)C3=O)NC(=O)NC2=O)=C(OC)C=C1 [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C2OC(=C([H])C2=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])SC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C2=C(O[C@]3(C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[C@]4([H])[C@](C([H])([H])[H])(C([H])([H])OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]13[H])C([H])=C(OC2=O)C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)N(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(N([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NC(=C([H])N=C2[H])C(=O)N([H])[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])[H])[C@@]1(O[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C2C(O[H])=NC(=N1)N([H])[H])C(=O)O[H] [H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C5=C(C([H])=C([H])C([H])=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]ON(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=NC(=C(O2)C([H])([H])[H])C([H])([H])[H])S1 [H]N(C([H])([H])[C@]1([H])O[C@]2([H])C3=C([H])C(=C([H])C([H])=C3N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=NC(=C1[H])C([H])([H])[H])C#CC1=C([H])\C(=N\OC([H])([H])C([H])([H])[H])[C@]([H])(F)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON(C(=O)[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C(=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(=C2[H])C(F)(F)F)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=NC2=C([H])C(Cl)=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)C([H])([H])SC1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C([H])C([H])=C4Cl)C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N([H])C1=NC([H])=NC2=C1N=C(Br)N2C([H])([H])C([H])([H])C([H])=C([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C([H])([H])O[C@@]1([H])C(=O)N2[C@]1([H])S(=O)(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C(=O)OC([H])([H])C(F)(F)F [H]N(C(=O)C([H])([H])SC1=NC(=C2C(=C1C#N)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C1=NN=C(S1)C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])C(=O)C1=C(OC(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)[C@]([H])(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C3=C(OC4=C(C([H])=C([H])C([H])=C4[H])[C@]12[H])C([H])=C([H])C([H])=C3C(=O)C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C1(N([H])C(=O)C2=C(F)C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]2(O[H])C([H])([H])C([H])([H])C3=C([H])C4=C(C([H])=NN4C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])[C@]23C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C3=C(C([H])=C2[C@]([H])(C([H])([H])C1([H])[H])C(F)(F)F)C(=C([H])C(=O)O3)C(F)(F)F [H]\C(C1=C([H])C([H])=NC([H])=C1[H])=C1/C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C1([H])[H] COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)C3(NC(=O)NC3=O)C3CCC3)C2=O)C=C1 [H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OP(=O)(O[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])[P@@](=O)(O[H])C([H])([H])[H] [H]N1C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)[C@]23C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@](C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])(C4([H])[H])C3([H])[H])C([H])([H])C1([H])[H] CCC1(CC(O)(CNC(=O)C2=C(N)N(N=C2)C2=CC=C(F)C=C2F)C(F)(F)F)CCCC2=CC=CC=C12 [H]C([H])=C([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@](C2=C([H])C(F)=C([H])C([H])=C2F)(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C([H])([H])N1C([H])([H])C([H])([H])C2(N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])N(C2=O)C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C2=C([H])C(=C([H])C(=C12)C([H])([H])[H])C([H])([H])[C@@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3F)C2([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N=C(S1)C1=NN(C([H])=C1[H])C1=C2C(=NC([H])=C1[H])N(C1=C([H])C([H])=C(N=C1C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])N(C([H])=N1)C(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C([H])C([H])=C12 [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(O[H])C([H])=C(O[H])C3=C1[C@@]1([H])[C@@]2([H])OC2=C([H])C([H])=C([H])C([H])=C2[C@@]1(O[H])C([H])([H])C3=O [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(OC3=C(C([H])=C([H])C([H])=C3[H])C(=N[H])N([H])[H])=N2)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C([H])=NC(=N1)C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(SC(=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=NC([H])([H])C([H])([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(S1)C([H])=C(Cl)C([H])=C2[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]\C(C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H] [H]O\N=C(\C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C3=C(OC2=O)C(=C(O[H])C([H])=C3[H])C([H])([H])[H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C1=NN=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C2C(=NC(=N1)C([H])([H])[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C(OC(=O)C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H] COC(=O)[C@@H]([C@@H]1CCCCN1)c1ccc(F)cc1 [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C#N)(C1([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C([H])([H])[N@+]2(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])[N+](=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])(OC2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])C([H])=C([H])C([H])=C2F)C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Br)C(=NO1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])[C@]([H])(N(C1=C2[H])C([H])([H])C(F)(F)F)C([H])([H])C(F)(F)F)C(F)(F)F [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=O)\C(N1[H])=C1\C2=C(N([H])C(=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=O)N([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1OC([H])([H])[H] [H]ON(C(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N([H])C(=O)[C@]([H])(O[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)OC21C2=C([H])C([H])=C(O[H])C([H])=C2OC2=C1C([H])=C([H])C(O[H])=C2[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])=C2[H])C2=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C2=O [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(S1)C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]OC1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C2=NC([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])N2C([H])=C([H])C3=C(C([H])=C([H])O3)C2=O)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(C([H])=C2O[C@]([H])(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])SC1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]OC(=O)C1=NN(N=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1F [H]N(C(=O)[C@@]1([H])ON=C(C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@@]1([H])C([H])([H])[C@]2([H])N([C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]C1=C(SC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NOC([O-])=N1)C([H])([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C(=NC([H])=C2[H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])OC3([H])[H])=C([H])C([H])=C1[H] [H]N=C1SC([H])=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C(=N2)C2=C([H])C([H])=C(F)C([H])=C2F)C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] COC1=C(C=CC=N1)C1=NC2=C(C)N=C(N)N=C2N(C(C)C)C1=O [H]N(C(=O)C1=NC(=NC([H])=C1Cl)S(=O)(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NN=C(SC([H])([H])C([H])([H])[H])S1 [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C(=NC([H])=C2[H])C2=NC([H])=C(N2[H])C(F)(F)F)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]12C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=NC(N([H])C3=C([H])C(=C([H])C([H])=C3S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C(C([H])=C(OC([H])([H])[H])C1=C3[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C(Cl)C([H])=N2 [H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])C([H])([H])C([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C12)C(=O)C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C3=C2C(=C([H])C(=C3[H])C(=O)C([H])([H])Br)C1=O [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=NC([H])=NC(N([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])=N1 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1OC(=C([H])C2=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC1=C(Br)C([H])=C(C([H])=C1Br)C1(OC(=O)C2=C([H])C([H])=C([H])C3=C2C1=C([H])C([H])=C3[H])C1=C([H])C(Br)=C(O[H])C(Br)=C1[H] [H]N(C(=O)C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])[C@]([H])(C1=NC([H])=C(N1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])S(=O)(=O)C(F)(F)F [H]N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C#N [H]N([H])O[S@@](=O)C1=NN=C(S1)N([H])C(=O)C([H])([H])[N+](C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])N2C([H])=C1C1=C([H])C([H])=C(F)C(Cl)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])=NC2=C1C([H])([H])[H])[C@@]([H])(N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C(=O)OC([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] OC1=CC2=C(C=C1)N(C(=N2)C1=CC2=CC=CC=C2C=C1)C1=CC=NC(N[C@@H]2CCCNC2)=C1 O=C(N1CCN(CC2=CC=C(C=C2)C2=NN=C3N2C2=CC=CN=C2NC2=C3C=CC=C2)CC1)C1=CC=CC=N1 [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C(=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])OC(=N2)C([H])([H])[H])C([H])([H])C1=O)C(F)(F)F [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=NN([H])C2=C1C([H])=C(C([H])=C2C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NC(=NO1)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])(C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(C#CC3=C([H])C([H])=C([H])N=C3[H])=C(OC([H])([H])[H])C([H])=C12 [H]C1=NC2=C(C(=NO2)C([H])([H])[H])C(SC2=C([H])C([H])=C([H])C([H])=C2Cl)=N1 [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=NC4=C(S3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] N[C@H](CC1=C(Cl)C=CC=C1)C(=O)N1CCN(CC1)C1=C2C=CC=CC2=NC=N1 [H]C1=C(SC2=C1C([H])=C([H])C(Cl)=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(N=NN2C([H])([H])C2=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C2[H])C(=N1)C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C([H])=C(S1)C1=C([H])C2=C(N=N1)C1=C(C([H])=C([H])C([H])=C1[H])C2=O [H]N(C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2[C@@]([H])(SC3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])S[C@]1([H])C(=O)N(C(=O)C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C(=O)C([H])([H])C1([H])[H] OC(CNCCNC(=O)CCCCCNC(=O)COC1=CC=C(\C=C\C2=CC=C3C=C4C=CC(C5=CC=CS5)=[N+]4[B-](F)(F)N23)C=C1)COC1=CC=CC2=C1C=CC=C2 [H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])OC3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@]1([H])C(=O)N([H])C(=O)[C@](OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] Cc1cnc(NCCN2CCOCC2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1 [H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)N2C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] CC1=CC=CC(F)=C1NC(=O)C1=NC2=C(NS(C)(=O)=O)C=CC=C2C(O)=C1 [H]N([H])C1=NN=C(SC2=NC([H])=C(S2)[N+]([O-])=O)S1 [H]C1=C([H])C(=C([H])O1)C([H])([H])N(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2C2=C(Cl)C([H])=NC(=N2)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C(Cl)C3=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C3=NN(N=N3)C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H])C([H])([H])O[H] [H]N([H])[C@]([H])(C(=O)C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1O[H])C([H])([H])C([H])([H])N(C1=C(O[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C(=O)C1=C([H])C(Br)=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Br)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2([H])N3C4=C(SC([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@]2([H])C1([H])[H] [H]N1C2=C(C3=C1C(=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C21 [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=NN(C(=O)C2=C(F)C([H])=C(F)C([H])=C2F)[C@]([H])(S1)C1=C([H])C([H])=C(F)C([H])=C1OC([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=NN([H])C(=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)SC3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1\C([H])=N\N([H])C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1 [H]N1C(=O)C(=O)C2=C1C([H])=C([H])C(\C([H])=C(/[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])=C2[H] [H]C1=NC2=C(C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)O[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[N+]2(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C2OC(F)(F)OC2=C1[H])C1=NN=C(O1)C1=C2N(C([H])=C(C2=C([H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[C@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] CCC1=C(C=CC=C1CN1CC(C1)C(O)=O)C1=NSC(=N1)C1=CC=C(CC(C)C)C(=C1)C#N [H]C1=NC(=C([H])C([H])=C1C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NSN=C23)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@](C#CC1=NC(N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C4=C(C(=NN4[H])C4=C([H])SC(C#CC([H])([H])OC5=C([H])C([H])=C([H])C([H])=C5[H])=C4[H])C([H])([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C(C([H])=C(C#N)C(OC2=C([H])C([H])=C(F)C(F)=C2[H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]ON([H])C(=O)C1=C([H])N=C2C([H])=C(C([H])=C([H])C2=C1N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]N1C(=O)N([H])[C@@]2(N(C(=O)N([H])C3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])[H])C1=O [H]C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C2([H])[H])C(OC2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N1C([H])=NC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(Cl)=C2[H] [H]N(C(=O)OC1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]21C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N1C2=C([H])C(=C([H])C([H])=C2C(=C1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]O[C@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl [H]OC1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])C([H])([H])[C@@]1([H])OC([H])([H])[C@]([H])(N([H])[H])C([H])([H])O1)[C@]([H])(C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H] [H]OC(=O)C1=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N=C(N=C1N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=C3C(=NN2C([H])([H])[H])C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]N(\N=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C#N)C(SC([H])([H])[H])=NS1 [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C(N([H])C(=O)S2)C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C23)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[C@]3([H])C([H])([H])[C@]3(C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1N=NN=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])OC([H])([H])C(=O)[C@@]12[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C(N=C(C([H])=C2C(F)(F)F)C(F)(F)F)=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC(=NN1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C(C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1F [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])OC(=O)O[C@@]1([H])C([H])([H])C([H])([H])[C@@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C(Br)=C1C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=C(C3=C([H])N=C(N=C23)N([H])C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C(N([H])C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C3=C(N=C([H])N3[H])C([H])=C2C(=O)N([H])C([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C(=O)O[H] [H]N([C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C#CC([H])([H])OC1=C([H])C([H])=C2N(C(=O)N=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N(C(=S)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N(C2=NC([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(SC3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C(Br)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=N1)C1=C([H])C(=O)N(C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C2=C([H])C([H])=C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])=C2[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]N1N=C(C([H])=C1C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN=NN1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=C([H])C2=C(N([H])C([H])([H])N2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C(F)=C([H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(Br)=C(N=C1OC([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=C([H])C([H])=C([H])C([H])=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC1=C([H])C([H])=C2C(=N1)C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C2C(=N1)C([H])([H])S(=O)(=O)C2([H])[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])[C@]3([H])N(C(=O)OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]2([H])C3([H])[H])C([H])=C([H])C([H])=C1[H] CN(C)C(=O)C1=CC(CN2CCC3=CC4=C(C=C3CC2)N=C(N)S4)=CC=C1 [H]N1N=C2N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N2C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(SC([H])=C2[H])C2=NN(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(F)(F)F [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C(=O)N2N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C(=O)O[H] [H]OC1(C([H])([H])C([H])([H])N(C2=NC(=C3C([H])=C(N([H])C(=O)C(\[H])=C(\C4=C([H])C([H])=C(OC(F)(F)F)C([H])=C4[H])C([H])([H])[H])C([H])=C([H])C3=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NC(=N1)C1=C([H])C(=NC([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1O2 [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[P@](=O)(O[H])C([H])([H])N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C1=C([H])C2=C(N([H])C(=O)\C2=N/N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])C1(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=NC(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]\C(C1=C([H])C([H])=C([H])N1C([H])([H])[H])=C1/C(=O)/C(=C(\[H])C2=C([H])C([H])=C([H])N2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1([H])[C@]2([H])[C@@]1([H])S(=O)(=O)C([H])([H])[C@@]2(N([H])[H])C(=O)O[H] [H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=O)C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(O[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1N(C2=NC(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C1=O [H]OC(=O)C(=O)N(C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C(=O)OC([H])([H])[H])C(O[H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])[H] [H]\C(=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(=C1C#N)C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])N(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1=O COC[C@H](C)OC1=CC(CCC2=CC=CC=C2F)=CC(=C1)C(=O)NC1=NN(C)C=C1 [H]N(C(=O)C1(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C(Br)=C(S1)C1=C([H])C(N([H])[H])=C([H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])OC3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])=C([H])C2=NC(=C1[H])C([H])([H])[H] [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H] [H]C1=C([H])C(N2C3=C(C(=NC4=C(F)C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C([H])=C1C1=NC2=C([H])C([H])=C([H])N=C2N1C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C(F)=C1[H])[C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] COC1=C(O)C=CC(\C=C\C=C\C(=O)C2=CC=CC=C2O)=C1 [H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=NC(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N1N=C(C2=C(C3=C([H])C(OC([H])([H])[H])=C([H])C(=C3N=C12)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])SC1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])[H])C1=NC([H])=C(S1)C([H])([H])C1=C(Cl)C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(C([H])=C2C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N=C([H])C([H])([H])[C@@]1([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C(=N1)N([H])[H] [H]ON(C(=O)N([H])[H])[C@]1([H])C2=C([H])C3=C([H])C(Cl)=C([H])C([H])=C3N2C([H])([H])C1([H])[H] FC(F)(F)C1=CC(OC2=NC=CC=C2NC(=O)NCC2=CC=CC=C2)=CC=C1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[C@@]([H])(C#N)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C2C(=C1[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(Cl)=C(N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C1=C([H])C([H])=C([H])C(N([H])[H])=C1[H] [H]C1=C(N2C([H])=C([H])C(=C(Cl)C2=N1)C1=C([H])C2=C(N(C([H])=C2[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])C(F)(F)F [H]N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2[C@]([H])(C(=O)N([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C(=S)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]C1=C2N(C#N)C([H])([H])[C@]3([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N1C2=NC([H])=C(Cl)N(C2=O)C([H])([H])C(=O)N([H])C([H])([H])C2=C(C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C2=C(C#N)C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C(Br)=C([H])C(=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(O[C@@]([H])(C#C[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])=C(C1=C([H])C([H])=C([H])C(=C1[H])C(N([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=S)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])SC(=S)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2[H])C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] CCC(=O)N1CCN(CC1)C1=CC=C(C=C1C(F)(F)F)N1C(=O)C(C)=CC2=CN=C3C=CC(=CC3=C12)C1=CN=C2C=CC=CC2=C1 [H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C([H])O1)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C(=O)N2C([H])([H])[C@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]2([H])C1([H])[H] CC1(C)OC[C@H](COC2=CC3=C(CCC4=C(C=CC(NC5=CC=C(F)C(NC(=O)C6=CC=CS6)=C5)=C4)C3=O)C=C2)O1 [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])SC([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CCC1=C(NC(=O)C2=CC(C)=NN2C)C=C(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)C=C1 [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])N=C1[C@]1([H])C2=C(C(=C([H])C([H])=C2[H])C2=C([H])N(N=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C(F)C(F)=C1[H] [H]C1=C([H])C2=C(C([H])=N1)C([H])=C([H])C(OC([H])([H])[H])=C2Br [H]C1=C(C2=NSN=C2OC([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])[N@+]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])[C@@]1([H])S[C@@]([H])(C2=C(OC([H])([H])[H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]N(C(=O)C1=C([H])C(=C([H])S1)S(=O)(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C(C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])[N+]([O-])=O [H]OC1=C2C([H])=C(C(=O)C(=C([H])C2=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=N[H])C([H])([H])C1=C(N(N=C1C(=O)N([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC1=C([H])C(F)=C([H])C2=C1OC([H])([H])C([H])([H])C2=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(/[H])S(=O)(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C(F)=C2[H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]C1=NN(C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)OC21C2=C([H])C([H])=C(O[H])C([H])=C2OC2=C1C([H])=C([H])C(O[H])=C2[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1C(F)(F)F)C(F)(F)F)[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(F)(F)F [H]N(C(=O)[C@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]1(C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=NOC(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N1C(=O)N(C(=O)N(C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2C([H])([H])N([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C1=NC([H])=C([H])S1)C2([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N(OC([H])([H])[H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C([H])([H])C1=C([H])C(I)=C([H])C([H])=C1[H] COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC=C(C=C3)C3=C(O)C=CC=C3)C2=O)C=C1 [H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] CN(C)CC1=CC=CC=C1SC1=C(N)C=C([123I])C=C1 [H]N1N=C(N([H])C1=O)C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)(F)F [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(OC(=S)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=C([H])C(C(=O)N([H])C3=C([H])C([H])=C4C(=C3[H])C3=C(C(=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C4([H])[H])=C(Cl)C([H])=N2)C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C(OC2=C(Br)C([H])=C(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])=C2Br)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C2([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])N=C2C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C(F)(F)F)C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=C(C(=O)O[C@@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C2N1C([H])([H])C([H])([H])N(C2=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(O[C@]([H])(C([H])([H])[H])C([H])([H])N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C5(C6=C([H])C([H])=C(Cl)C([H])=C6[H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])N=C([H])N12)\C([H])([H])[H] [H]OC1=C([H])\C(=N\C2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=NC([H])=N2)C(=O)C(Br)=C1[H] [H]N(C(=O)[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])C2(OC(=O)N(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=NN2C([H])=C([H])C([H])=C([H])C2=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]