[H]OC(=O)[C@]1([H])[C@@]([H])(SC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C(=O)N=C2C([H])=C([H])C([H])=C([H])N2C1=O
[H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=NN2N=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(C#N)=C2[H]
[H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C3C(=O)C4=C(N([H])N=C4C3=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=C(SC(=N1)N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
CC(C)CC1=CC=C(C=C1)C(C)C(=O)OCCNS(=O)(=O)C1=CC=CC2=C(C=CC=C12)N(C)C
[H]O[C@]1([H])[C@]([H])(O[H])[C@@]([H])(C([H])([H])[H])[C@@]23OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(C2([H])[H])C([H])([H])[C@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]3(C([H])([H])[H])[C@@]1([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(\C([H])=C(\[H])Br)C([H])=C1[H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN=C(O1)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC([H])=NC2=C1SC([H])=C2[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C([H])=N1)C1=NC(N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
CN(C)CC[C@H](CSC1=CC=CC=C1)NC1=C(C=C(C=C1)S(=O)(=O)NC1=C2CCN(CC2=NC(Cl)=N1)C1CCN(CC2=C(C=CC=C2)C2=CC=C(Cl)C=C2)CC1)S(=O)(=O)C(F)(F)F
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N1CCN(CC1)C1=NC=NC2=C1C=CN2
[H]N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C3([H])C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4F)C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]C([H])=C(C1=C2OC(=NC2=C([H])C(C#N)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N(C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(SC3=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C23)C(=O)N([H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N1N=C(OC1=S)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=N/OC([H])([H])C([H])([H])C([H])([H])[H])\C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C(F)=C([H])C([H])=C2C1=O
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H]
[H]N(C1=C([H])C2=C(N=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C2=C3N(C(=O)C4=C(OC(=O)C([H])=C4OC(=O)C4=C([H])C([H])=C(F)C([H])=C4[H])C3=C1[H])C([H])([H])C2([H])[H]
[H]N([C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])[C@]12C([H])([H])C([H])([H])[C@](C3=NC4=C(N3[H])N(C(=O)N(C4=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N([H])C1=NC([H])=NC2=C1C(=NN2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C2=C1C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(=C([H])C(=C2O1)C([H])([H])[H])C([H])([H])[H]
CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c1ccc(C)cc1
[H]OC(=O)C1=NN([H])C(=C1F)C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(Cl)S2)C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C2SC([H])=C(C2=C1[H])C1(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=NC(=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([O-])=O
[H]O[C@@](C([H])([H])N([H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])N=C1Cl)C([H])([H])C([H])([H])[H])C(F)(F)F
[H]O[C@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])OC(=N2)C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])=C1[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC(=O)C([H])([H])C1=C2N(C3=C([H])C(F)=C(F)C([H])=C13)C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H]
[H]O[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
C[N@@H+]1CCC[C@H]1CCNc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=N[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])O1
[H]N(C1=C([H])C(OC([H])([H])[H])=C(F)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C3C([H])=C12
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])=C(C4=C([H])N=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C([H])C(OC3=C([H])C([H])=NC(=C3[H])C(=O)N([H])C([H])([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
NC1(CCN(CC1)C1=NC=NC2=C1C=CN2)C(=O)NC(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
[H]OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C2=NN(C(=O)C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])C(O[H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(OC(F)(F)F)C2=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])C(=O)N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])[C@@]([H])(N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C3C([H])=C(OC4=C(C#N)C([H])=C([H])C(=C4[H])C([H])([H])N4C([H])=NC([H])=C4C([H])([H])N([H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])=C([H])C3=C([H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1=C(Cl)C([H])=C([H])C(=C1[H])C(F)(F)F)[N+]([O-])=O
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])S1)C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C(OC([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1(OC(=O)\C(=C(/[H])C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)C1([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C(Br)C([H])=C(Br)C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C2=C(C(=O)[C@]([H])(C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
NC(=O)C(CN1CCC2(CC1)OCCC1=C2SC(Cl)=C1)CC1=CC=CC=C1Cl
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C(=NC3=C([H])C(F)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C#CC([H])([H])N1C(=O)C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)S\C(=C(\[H])C2=C(OC([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C([H])C(Br)=C2[H])C1=O
CC(OC1=C(C=O)C=CC=C1)C1=NCCN1
[H]OC1=C([H])C(=C2OC([H])([H])C(=O)N([H])C2=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]3([H])C([H])([H])C([H])=C4C([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@]4(\C([H])=C(/[H])F)[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])C(OC2=C(F)C([H])=C(N([H])C3=C(C([H])=NC([H])=C3[H])C(=O)N([H])C3=C([H])C([H])=C(F)C([H])=C3F)C([H])=C2[H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(\C(=N/C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NOC(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1Cl
CC1=CN2C(NC3CCCCC3)=C(N=C2C=C1)C1=CC=C(OCCCNC(=O)NC2=CC=C(C=C2)C(F)(F)F)C(Cl)=C1
[H]C1=C([H])C([H])=C2N3C(SC2=C1[H])=NC(=C([H])C3=O)C([H])([H])OC(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N1C(=N2)C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[P@](=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(C(=NN2C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C2=C([H])N=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(Cl)C(=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Br)=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C(S1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C([H])=C(C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C(F)=C([H])C4=N3)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C(C#N)C([H])=C1[H]
[H]N1C(=O)\C(=C(\[H])C2=C([H])C([H])=C(I)O2)C(=O)N(C1=S)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])OC1=C(OC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C(=NC(=N1)C([H])([H])[H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(N=C(N=C3N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])N3C4=C(N=C3C3([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[H])N2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N1C(=O)N(C2=C(C(=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N=C(N([H])[H])N([H])\N=C(/C1=C([H])C([H])=C([H])C(OC([H])([H])C(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C(=N\N([H])C(=N[H])N([H])[H])\C([H])([H])[H])C(=N/N([H])C(=N[H])N([H])[H])\C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])SC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]C1=C(C#N)N(C(=C1[H])C1=C([H])C(F)=C2N(C(=O)C(C2=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[H])[C@]1([H])O[H]
[H]OC(=O)C1=C(OC2=C(C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])N([H])C2=C([H])C([H])=C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C(=C2[H])C(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=C2[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12
[H]N([H])C(=O)C([H])([H])C1=C(N(N=C1C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C#N)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OP(=O)(O[H])C1=C(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C(Br)C([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(F)C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C(N([H])[H])=C1[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])O[H])C([H])([H])C([H])([H])[C@@]1([H])[C@](O2)(C([H])([H])[H])C([H])([H])C([H])([H])I)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=O)N(C1=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C(=C2C(=O)O1)C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(N=C([H])N=C2O1)N1C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H]
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[H]\C(=N/N(C([H])([H])[H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C(OC([H])([H])C([H])=C([H])[H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N1C(=NC2=C1N([H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
CC(C)N1CCN(CC1)C(=O)C1=CC=C2C(CN3CCOCC3)=CN(C)C2=C1
[H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(SC(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C2([H])[H]
[H]OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C1=NC(=NC(=C1[H])C([H])([H])[H])C1=C([H])C(F)=C(Br)C([H])=C1[H]
[H]N(C(=O)C1=NC(=NC([H])=C1Cl)S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])SC([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C(OC([H])([H])[H])=C1O[H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C(O[H])=C(O[H])C(OC([H])([H])[H])=C1[H])[N+]([O-])=O
[H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]C([H])=C(C(=O)N([H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])N(C1=C([H])C([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])C([H])=N1)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)C(=O)O[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C(N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])=C2C([H])=NC3=C([H])C([H])=C([H])C([H])=C3N12
[H]O[C@]1(C(=O)OC([H])([H])[H])C([H])([H])[C@@]2([H])O[C@@]1(N1C3=C([H])C([H])=C(C([H])=C3C3=C1C1=C(C4=C(C([H])=C([H])C(=C4[H])C([H])([H])OC([H])([H])[H])N21)C1=C3C([H])([H])N([H])C1=O)C([H])([H])OC([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])O2)C(OC([H])([H])[H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C(=NC(=N2)N([H])[H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C(C#N)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]C1=[N+](C([H])=C(S1)C([H])([H])[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C(=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H]
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[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(O[H])N=C(N=C2C([H])=C1[H])C([H])(F)F)C(=O)O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1\C([H])=C(/[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C(=N[H])N([H])[H]
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[H]N(C1=NN=C(O1)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H]
[H]N(\N=C1/C(=O)N([H])C2=C1C(Cl)=C([H])C([H])=C2Cl)C(=O)[C@@]([H])(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H]
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[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C#CC1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C(=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H]
[H]C1=C([H])C([H])=C(N2N=C(C(=O)N3C([H])([H])C4=C(C([H])=C(Br)C([H])=C4[H])C3([H])[H])C(=C2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C#N)C(Cl)=C1[H]
ON(=O)C1=CC=CC(=C1)C(=O)NC1=C2N=NN(CC3=CC=CC=C3)C2=NC(=N1)C1=CC=CC=C1
NS(=O)(=O)C1=CC(NC2=C3C=CC=CC3=C(N=N2)C2=CC=CC=C2)=CC=C1
[H]N(C(=O)C1=NN=C(O1)N([H])C1=C([H])C(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])[C@]([H])(C(=O)C1=C([H])C([H])=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=C([H])C(F)=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=C([H])S1
[H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])=N3)C([H])([H])C2=C([H])C([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(=O)C2=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N(C1=C([H])C(=NC(=O)N1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)\C(=C(/[H])C(=O)C2=C([H])N=C([H])C(Br)=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C12
[H]C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])=C(C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C2SC(C#C[C@@]3([H])N([H])C([H])([H])[C@]([H])(OC(=O)N([H])C([H])([H])[H])C3([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C1=C(C(=O)C([H])([H])OC(=O)C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(S2)C([H])([H])[H])C(=O)N(C(=O)N1C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(N=C([H])C([H])=C1[H])C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(N([H])[H])=[N+]([H])[H]
[H]N([H])C1=N[C@](C2=C([H])C(N([H])C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C(F)=C4[H])=C([H])C([H])=C2F)(C([H])([H])[H])C([H])([H])C([H])([H])S1
[H]N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C1=C(C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])SC([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]12C(=O)N(C(=O)[C@]1([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(C1=C([H])N(C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2OC1=O
[H]C1=NN(C(=C1C1=NN=C(SC([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])C([H])([H])N(C2=C(Cl)C(=O)N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N(C1=C(OC([H])([H])[H])C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])S1)C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(N([H])C3=NN4C(=C([H])C([H])=C4C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=N3)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2N2N=C(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C2C([H])([H])[H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
NS(=O)(=O)C1=C(F)C(F)=C(SC2=NC3=C(S2)C=CC=C3)C(F)=C1F
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@]([H])([C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
O=C(NC1=CN2N=C(OC3=CC(NC(=O)C4=CC=NO4)=CC=C3)C=CC2=N1)C1CC1
[H]OC1=C(\C([H])=C(/[H])C([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H]
[H]OC1=C(C(=O)N([H])C([H])([H])C([H])([H])[H])C(O[H])=C(C([H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]OC1=C([H])C([H])=C(\C([H])=N\OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])=NC2=C1N=C(N1N=C(N=C21)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC(=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C(Cl)=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(=O)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])=C([H])C([H])=C1Cl
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C(=O)C1=C([H])OC([H])=C1[H]
[H]O[C@]1(C2=NC([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C(C4=C(N3[H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C2=C1[H]
[H]C1=NC2=C(C([H])=C1[H])N1C(=NC(=C1C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N2C1=C(Cl)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N=C(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C#C[H]
[H]OC1=NC([H])=C([H])N1C([H])([H])[C@@]([H])(C1=C([H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H]
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[H]N=C1SC([H])=C(N1C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
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[H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])S1
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[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])\N=C2/C(=O)N([H])C3=C([H])C([H])=C(I)C([H])=C23)C([H])=C1[H]
[H]C1=C([H])C(Cl)=C2C([H])=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
[H]N(C(=O)C1(N([H])C(=O)C(F)(F)C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C(=O)OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N(C(=C1C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])N4C([H])([H])C([H])(O[H])C4([H])[H])C(=C3[H])S(=O)(=O)C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2O[C@@]3([H])[C@]([H])(OC(=O)N(C4=C([H])C([H])=C([H])C([H])=C4[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2N([H])C3=C([H])C([H])=C(Cl)C([H])=C3C2=NC([H])=N1)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])N(N=C1[H])C1=C([H])C(=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])N=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=NC(=O)N(C2=C([H])C([H])=C(C([H])=C12)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
OC(=O)CC1=CC(Br)=C(N(CC2=CC=C(OC3=CC=CC=C3Cl)C=C2)CC2=CC(F)=CC(F)=C2)C(Br)=C1
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])[C@@]1([H])O[H]
[H]OC(=O)C1=C(O[H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
CC(=O)N[C@@H](CC1=CC(F)=CC(F)=C1)[C@H](O)CNC1(CCCCC1)C1=CC(CC(C)(C)C)=NO1
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)N(C([H])([H])C1=C([H])C2=C(N=C(N([H])C2=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])O[H])C(=O)O[H]
[H]OC1=C(N([H])[H])C([H])=C2C([H])=C3C(=NC2=C1[H])C1=C([H])C2=C(C(=O)N1C3([H])[H])C([H])([H])OC(=O)[C@]2(O[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C12)C1=C(F)C([H])=C([H])C2=C1OC([H])([H])O2
[H]C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3Cl)=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=NC(=C(Cl)C([H])=N2)C2=C([H])C([H])=C(C([H])=C2[H])C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(Cl)C(Cl)=C(C([H])=C1S(=O)(=O)N([H])[H])S(=O)(=O)N([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(=C(N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)[C@]1([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(SC3=C([H])C([H])=C([H])C([H])=C3C([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C2Cl)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(\S[H])=N\C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)C(=O)N1C([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])C([H])([H])N([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]N1C(=O)C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C#N)C(=C([H])C(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C1=C(Cl)C(=C([H])C([H])=C1[H])C(F)(F)F)[C@@]([H])(C([H])=O)C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])F)=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H]
OB(O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)C1=CC=NC2=CC=CC=C12)C1=CC=CC=C1
[H]N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C(SC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=C(C(=NN1C1=NC([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(C#CC2=C([H])N=C3N2C([H])=C([H])C([H])=C3N([H])C(=O)C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])=NC([H])=C1[H])C(F)(F)F
[H]C1=C(C(=O)C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])[H]
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[H]ON([H])C(=O)C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=C3C([H])=C([H])C(Cl)=C([H])C3=NC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])[C@](C3=NN=C4N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]N(C(=O)C1=C([H])C2=C(N=C(N=C2N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N2C([H])=NC3=C2C([H])=NC([H])=C3[H])N1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H]
[H]C1=C(Cl)C([H])=C(Cl)C(=C1[H])C1=C2N=C(C([H])=C(N2N=C1C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])O[11C]([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(O[H])N=C(N=C2C([H])=C1[H])C(F)(F)F)C(=O)O[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=NC(=NC(=C1[H])C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C([H])S1
[H]OC1=C([H])C([H])=C(C([H])=C1[C@]([H])(C(=C([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C(\[H])=C(/[H])C1=C([H])C(Br)=C(O[H])C([H])=C1OC([H])([H])[H]
[H]N1C(=O)S[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=NC([H])=C([H])N2C1=NC(=C2C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C2=NN=C3SC([H])([H])C(=NN23)C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C(Cl)=C1[H]
[H]N1C(=O)N([H])C(C1=O)(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NN=C(S2)C2=C([H])OC([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=NN=C(S2)C2=C([H])C(C#N)=C(C([H])=C2[H])C2=C([H])C([H])=C([H])S2)C(=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@]([H])(OC2=C([H])C([H])=C(N([H])C3=NC([H])=C4C([H])=C(C(=O)N(C4=N3)C([H])([H])[H])C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])=C2[H])[C@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H]
[H]N1C([H])=C2C3=C1C([H])=C(C([H])=C3[C@@]1([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2S(=O)(=O)N1C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2=NC(C#N)=C3N=C([H])N(C3=C2[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
CC1=C(C)C(C)=C(C)C2=C1CC(C2)NC[C@H](O)C1=C2C=CC(=O)NC2=C(O)C=C1
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN2C([H])=NN=C2C([H])=C1[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C2OC([H])=C([H])C(=O)C2=C(C([H])=C1[H])[N+]([O-])=O
[H]OC1=C([H])C([H])=C2C(=N1)C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C#CC1=C([H])N(C(=O)C(=N1)N([H])C1=C(N=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(Cl)C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(C([H])([H])[H])[C@]([H])(SC(=O)C([H])([H])[H])C(=O)C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1O[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=O)N(C1=O)C([H])([H])C([H])([H])C(=O)O[H]
[H]N(C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=C1N=C([H])N2[C@]1([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]([H])(OC([H])([H])[H])[C@@]1([H])OC([H])([H])[H])C#CC1=C([H])C([H])=C(C([H])=O)C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NN(C([H])=C3C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2OC([H])([H])C([H])([H])[C@@]([H])(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1[C@@]([H])(SC([H])([H])[C@@]1([H])C(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=NC3=C(SC4=C([H])C([H])=C(C([H])=C34)C3=C([H])C([H])=C([H])C([H])=C3[H])C(=O)N2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NSC([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])[C@]2([H])C([H])=NN([H])[C@]2([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)C1=C([H])C([H])=C2C([H])=C(N([H])C2=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C2=NC3(N=C2C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C31)C([H])([H])[H]
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C(F)C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C(=C(C([H])=C1C1=NOC(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=O)OC3=C([H])C([H])=C([H])C([H])=C23)C([H])=C1[H]
[H]SC1=NC2=C([H])C([H])=C(C([H])=C2C11C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(C#N)=C([H])C(F)=C1[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC([H])=C([H])N1[H]
[H]N(C1=C(Cl)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(=O)C([H])([H])C1=C(C#N)C([H])=C2OC([H])([H])OC2=C1[H]
[H]C1=C(N(N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4N=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H]
CN(C)C(=O)OC1=CC=C(C=C1)C1=CN2C(C=CC=C2NC=O)=[N]1C
[H]N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=O
[H]OC(=O)C([H])([H])C([H])([H])[C@@](N([H])[H])(C(=O)O[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=NN([H])C2=NC(C3=C([H])C([H])=C([H])S3)=C(Br)C([H])=C12
[H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(F)C(F)=C([H])C([H])=C2F)C([H])([H])C1([H])[H]
[H]OC1=C2O[C@@]3([H])C(=O)C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H]
[H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)\C(O2)=C(/[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]N([H])C1=NC2=C([H])C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C(C([H])=C2C(=N1)N([H])[H])C([H])([H])[H]
[H]N(C1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]OC1=C2N([H])C(=O)C([H])=C([H])C2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C1([H])C([H])([H])C2=C(C([H])=C(C(=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)C1=C(F)C([H])=C([H])C([H])=C1F
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C3=C([H])C4=C(OC([H])([H])OC4([H])[H])C(=C3[H])C([H])([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C(=C4[H])C2([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC1=NC(OC2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])N([H])[H])=C(F)C([H])=C1F
[H]OC(=O)C([H])([H])OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(Br)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(O[H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C3=C([H])C([H])=NC(=N3)C([H])([H])[H])C3(C2=O)C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C3([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H]
[H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1[H])C([H])([H])C([H])([H])C([H])([H])[H])C(O[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=NN2C([H])=C(C3=NN=C(O3)SC([H])([H])[H])C(=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C1[H])N([H])C(=C2[H])C([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(C#CC3=C([H])C([H])=C([H])N=C3[H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=C([H])C(Br)=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H]
[H]N([H])[C@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C([H])C(=C23)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC4=C5C([H])=C([H])SC5=C([H])C([H])=C4[H])C(Cl)=C3[H])=C12
[H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C([H])([H])[H])[C@]([H])(N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])C2=NC([H])=NC(=C2[H])N(C2=C([H])C([H])=C(C([H])=C2Br)C([H])([H])[H])C([H])([H])C#N)C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(O[H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])[C@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]OC1=C([H])C(O[H])=C(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H]
[H]O[C@]1(N2C(=NC([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C2=C([H])C(F)=C([H])C([H])=C2C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C(F)C(=NC([H])=N1)C([H])([H])[H]
[H]N([C@]1([H])C(=O)N(C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1
[H]N([H])C1=NC(N([H])[H])=C2C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3OC([H])([H])[H])C([H])=NC2=N1
[H]N(C1=C([H])C(=NC2=C(C#N)C([H])=NN12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC(F)(F)C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H][C@@]12C[C@H](OC(=O)C3=CC=CC=C3I)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1
[H]OC1=C(Cl)C([H])=C2C(=C1Cl)[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1=NN=C(N1C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])N1C(=O)C([H])([H])OC2=C(C([H])=C(Cl)C([H])=C12)S(=O)(=O)C([H])([H])[H]
[H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C2=C([H])C([H])=C3C(=O)N([H])C([H])([H])C3=C2C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C#N)C#N)C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])=C([H])C2=C3N(C([H])=NC3=C([H])N=C12)C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(Cl)C(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C3=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])O3)S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])=C12
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])[C@@]2([H])C(=NC3=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3C2=O)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C(Cl)C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]1(C(=O)O[C@]([H])(C([H])=C(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(OC(=O)C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=NC([H])=C([H])C([H])=C1[H]
[H]C#CC([H])([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=NN=C1C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C(F)(F)F
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[H]N(C1=NC([H])=C([H])C(=C1[H])C1=NN([H])C(=O)N1C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]C1=NC(OC2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C(=C2C(=O)O1)C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N([H])C([H])=C(C2=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2O1
[H]N(C1=NC(=NC(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H]
[H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=C([H])C([H])=N2)C1=S)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@]1([H])C([H])([H])O[C@@]([H])(O[C@]1([H])C1=C([H])N=C([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])[N+]([O-])=O)(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2[N+](=C1C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])[C@@]12N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N(C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)N(C3([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=C([H])C(=C([H])C([H])=C1C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1OC(=C([H])C2=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])N(C(=C1[H])C(=O)C1=C([H])C2=C(OC([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(Cl)C([H])=C2N([H])C(=O)[C@]1([H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N([H])C1=C(C(=NC2=C([H])C([H])=C([H])C(Cl)=C12)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C(F)(F)F
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C([H])C(F)=C([H])C([H])=C2[H])N=C(SC([H])([H])[H])N=N1
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[C@@]3([H])OC([H])([H])C([H])([H])C3([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C(OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C#N)N1C([H])([H])[H]
[H]SC([H])([H])[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
OC1(CNS(=O)(=O)C(F)(F)F)CCN(CC1)S(=O)(=O)C1=CC2=CC=CC=C2N1S(=O)(=O)C1=C(F)C=CC=C1
[H]N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2S1(=O)=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)OC([H])([H])C1=[N+](C([H])=C([H])C([H])=C1OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])N=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C1=C(C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])N(C([H])([H])C1=C3C([H])=C([H])C([H])=C([H])C3=NC([H])=C1[H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC2=C(N1[H])C([H])=C1N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)N3C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2[H]
[H]N(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C2C(=O)C(C3=C([H])C4=C(OC([H])([H])C([H])([H])O4)C([H])=C3[H])=C(OC2=C1[H])C(F)(F)F
[H]N([H])C1=C(\C([H])=N\OC([H])([H])[H])C(=NC([H])=N1)N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N1N=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C2=NC3=C(N2[H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C(N([H])C2=C([H])C(Cl)=NC(=N2)N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=C(C#N)C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C1=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C([H])C([H])=C2C(C2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])[H])=C1C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)S(=O)(=O)C([H])([H])[H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC([H])=C(F)C(=O)N2C([H])([H])C2=C(C#N)C([H])=C([H])C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(C#N)C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C(N=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C(=NC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])Br
[H]OC1=C([H])C([H])=C(\C([H])=N\N([H])C(=O)N([H])\N=C(/[H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])[H]
[H]N(C1=C(C#CC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=NC([H])=N1)C([H])([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=C2N=C(N(C2=NC([H])=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])SC1=C2SC(=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC1=NC2=C(N=C1O[H])C([H])=C(OC([H])([H])[H])C(Br)=C2[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C(C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=S)N([H])C1=C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C([H])C([H])=C1[H])C(=O)C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N([H])C(=O)[C@@]1([H])[C@]([H])(S[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C1N(C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12
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ClC1=CC=C2OC(=NC2=C1)N1CCC(CC1)C(=O)N[C@@H]1CCC[C@H]1OCC1CCCC1
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[H]N(C(=O)C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C3=C(OC4=C(C([H])=C([H])C([H])=C4[H])[C@]12[H])C([H])=C([H])C(F)=C3[H]
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CCC1=C(OC2=CC=CN=C2C)N=CN=C1N1C2CC3CC1CC(C2)N3C(=O)OC(C)C
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=NC(=O)C([H])([H])S2)[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
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[H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=NC([H])=C([H])C(Cl)=C1[H]
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[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]1([H])C(=O)C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])N(C3=C2C(F)=C([H])C([H])=C3[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])SC2=C([H])C(O[H])=C([H])C([H])=C2S[C@@]1([H])C1=C([H])C(Br)=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])N=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]C1=NC(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(Cl)C([H])=C(C([H])=N4)C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C(Cl)C([H])=C1C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(N=C3N2C([H])([H])C([H])([H])C(=O)N3C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]N([H])[C@]([H])(C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N1C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(F)=C([H])C([H])=C2[H])=NC2=NC([H])=C([H])C([H])=C2C1=O
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C(F)=C([H])C([H])=C2O\C1=C(\[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(O[H])=C1[H]
COC1=C(C=CC=C1)C1=CC=C(CO\N=C(/C)C2=CC=C(CNCCC(O)=O)C=C2)C=C1
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C([H])([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])[C@@]([H])(N1C([H])([H])[C@]([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]N1C(=O)\C(N([H])C(=O)\C1=C(/[H])C1=C([H])C([H])=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S1)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C2C(=NC([H])=N1)N=C(C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])=C2C1=C([H])C(Br)=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@@]12C([H])([H])C([H])([H])C(=O)[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H]
[H]N1N=C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(\[H])=C2/C(=O)N([H])C3=C(C([H])=C(C([H])=C23)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C([H])([H])OP(=O)(O[H])O[H])N1C([H])=C(C(=O)N([H])C1=O)C1=C(C(OC([H])([H])[H])=C(C(=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(N=C3N(N(C(=O)C3=C2C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])[C@](N([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1Br)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C([H])=C(C4=C([H])C(F)=C([H])C([H])=C34)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(=C(Cl)C(Cl)=C1N1C(=O)C2=NC([H])=C([H])C([H])=C2C1=O)S(=O)(=O)N([H])[H]
CC1=CC=CC(NC2=C3N=CN(C4O[C@H](CO)[C@@H](O)[C@H]4O)C3=NC=N2)=C1
[H]OC(=O)C([H])([H])N1C(=S)S\C(C1=O)=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C(=O)O[H]
[H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C(=C2C(=O)O1)C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])N(N=C2C1=C([H])C([H])=C(O[H])C([H])=C1O[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O
[H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NC([H])=C(S2)C2=NC([H])=C(O[H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])[C@]([H])(N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)[C@@]1([H])OC2=C(C([H])=C(F)C([H])=C2[H])[C@@]2(N([H])C(=O)N([H])C2=O)C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=O)C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C2=C(Cl)C([H])=C([H])C([H])=C2C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H]
[H]N(C1=C([H])C2=C(N([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C1C([H])=C(S2)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)C2=C(SN=C2C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N=C1C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN=C(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C1=NC(=NC(=N1)N([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])N=C([H])O2)C(OC([H])([H])[H])=C1[H]
[H]N([H])[C@]([H])(C([H])([H])OC1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C(N([H])C(=O)C2=O)C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)C([H])([H])N([H])C(=O)[C@]1([H])N(C(=O)[C@]2([H])N(C(=O)[C@]3([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C4C3([H])[H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]ON([H])C(=O)[C@]([H])(N1C(=O)[C@@](C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
Cc1cnc(NCC2CCOCC2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N(C([H])=C([H])N=C2N([H])[H])C(=N1)[C@@]1([H])C([H])([H])[C@@](O[H])(C([H])([H])[H])C1([H])[H]
[H]ON([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1O2
CCC1=C(C=CC=C1CN1CC(C1)C(O)=O)C1=NSC(=N1)C1=CC=C(OC(C)C)C(=C1)C(F)(F)F
[H]N(C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(N=NN1C([H])([H])[C@]1([H])OC(=O)N(C2=C([H])C([H])=C(C(F)=C2[H])C2=C([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])C1([H])[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(OC([H])([H])[C@@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C(=O)C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])S[C@@]([H])(N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1Cl
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C(C([H])=C(C([H])=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C([H])([H])OC1=C([H])C2=C(OC([H])([H])O2)C([H])=C1Cl
[H]N(C1=C2C([H])=C(SC2=NC([H])=N1)C1=C([H])C([H])=C(N1[H])C([H])([H])N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H]
[H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]O\N=C1\C(\N([H])C2=C([H])C([H])=C(Br)C([H])=C\12)=C1\C(=O)N([H])C2=C1C([H])=C(N([H])[H])C([H])=C2[H]
[H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C(F)C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C(=O)O[C@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]1([H])[C@]([H])(N(C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2(C1=O)C([H])([H])C([H])([H])N(C(=O)C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H]
[H]N1C2=C([H])C(=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[N@]2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C([H])=C([H])C([H])([H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])([H])C1([H])[H])C(OC1=C2C(O[H])=C([H])C(=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C#N)C(=C(N1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Br)=C([H])N=C1[H]
[H]N(C(=O)C1=C([H])N=C(S1)N([H])C1=NN=C([H])C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C3=C4C(=C([H])C([H])=C3[H])C(=O)N([H])C([H])([H])[C@@]24[H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C1=C(N(N=C1[H])C1=NC([H])=C(O[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=C1[H])N(C([H])=C(C(=O)OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C2C(=C1[H])N(C(=O)C21C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C2N(C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])\N=C(/N([H])[H])[N+]([H])([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])Cl)C1=C([H])C([H])=C2C(=O)N([H])C(=O)C(=O)C2=C1[H]
[H]N(C1=C2N=C([H])N(C2=NC(=N1)C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]O[C@]1([H])C([H])([H])S[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]1([H])O[H]
[H]O[C@@]1([H])C([H])=C([H])[C@@]2([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(C([H])=C([H])C(C5=C([H])C([H])=C([H])O5)=C4O[C@@]12[H])C3([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(Br)C([H])=C(F)C([H])=C3N2C([H])([H])C1([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C#N)C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N1C2=C(C([H])=C(Br)C([H])=C2[H])C2=C1C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C2([H])[H]
[H]N1C(=O)\C(=C(\[H])C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C2=NC([H])=C([H])C([H])=C12
[H]N1C2=C(C([H])=C([H])S2)C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C(N([H])C(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(=O)C([H])=C(N([H])C(=O)\C(=C(/[H])\C(\[H])=C([H])/[C@]([H])(OC([H])([H])[H])[C@@]([H])(OC(=O)N([H])[H])\C(=C([H])\[C@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=O
[H]OC1=C([H])\C(C([H])=C([H])C1=O)=C1\N([H])N2C(SC1([H])[H])=NN=C2C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=NC([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C(F)=N1)[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]C1=C2N(C(=O)[C@@](N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])(C2=C([H])C(Cl)=C1[H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1N=NC(=N1)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OP(=O)(O[H])OC([H])([H])[C@@]([H])(N([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])[H])C2=C(N=C(N=C2S1)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C1=NN=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H]
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CCc1cnc(N)nc1-c1c[nH]c(c1)C(=O)NCc1cccc2ccccc12
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[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)N(C([H])([H])[H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(O1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C(C#N)=C(N1C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)S2)[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])=C(C([H])([H])[H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C2=C(C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(N([H])C([H])([H])N([H])S2(=O)=O)C([H])=C1SSC1=C([H])C2=C(C([H])=C1S(=O)(=O)N([H])[H])S(=O)(=O)N([H])C([H])([H])N2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
C\C=C/C(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C(=O)OC(C)(C)C
[H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N2[H])C([H])([H])C(=O)C([H])([H])[H]
[H]C1=NC2=C(C(=NN2C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N2C(=O)C(=O)N([H])C3=C([H])C(Cl)=C([H])C(=C23)C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N([H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=C([H])C(=C2C([H])=C([H])C(=O)C([H])=C12)C([H])([H])[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])SC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])C([H])=C([H])O1
COC1=C(F)C2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CN=CC(NC(=O)C4CCN(C)CC4)=C3)C2=O)C=C1
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(S[C@]([H])(C2=C(N=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)=C1[H])C(=O)OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=NN2C(=N1)N(C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(=C(C(=O)OC([H])([H])C([H])([H])[H])[C@]2([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=NN1C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]3([H])N([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CN1CCN(CC2=C(C=C(NC(=O)C3=CC(C#CC4=CC5=C(NN=C5C5=CC=CC=C5)N=C4)=C(C)C=C3)C=C2)C(F)(F)F)CC1
[H]N1C(=O)C([H])=C(C2=C([H])C([H])=C(C([H])=C12)N1C(=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@]([H])(O[C@@]2([H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@@]([H])(O[C@]2([H])C([H])([H])O[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC1=C([H])C(=C([H])C(OC([H])([H])[H])=C1O[H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])[N+]([O-])=O
[H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])=C1[H]
[H]N([C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=NC2=C([H])C(=C([H])C([H])=C12)C1=NC(=C([H])C(=N1)C([H])([H])S(=O)(=O)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(OC([H])(F)F)C(OC([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=[N+]([O-])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(CCCl)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CC=CC=C1
COC1=CC=C(\C=C\C2=C(/C=C/C(=O)NCCCN3CCOCC3)C(OC)=CC(OC)=C2)C=C1
[H]C1=C([H])C([H])=C2C(=C1[H])C(=C(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1=C([H])N=C([H])C(=N1)C([H])([H])[H]
[H]N([H])C1=NC([H])=C([H])N=C1C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F
CN(C(=O)CN1C(=O)OC2=CC=C(C=C12)C1=CC=CC(=C1)C(F)(F)F)C1=CC=CC=C1
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2Cl
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])[C@]([H])(C([H])([H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C1C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])[H]
[H]C1=C([H])C(=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@@]2(OC([H])([H])[H])C([H])=C([H])[C@]11[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]11C4=C(C([H])=C([H])C(OC([H])([H])[H])=C4O[C@@]21[H])C3([H])[H])[N+]([O-])=O
[H]N([H])C([H])([H])C1=C([H])C(=C([H])C(N([H])C(=O)[C@@]2([H])C([H])([H])C3=C([H])C(OC4=C([H])C([H])=NC(=C4[H])C(=O)N([H])C([H])([H])[H])=C([H])C([H])=C3C([H])([H])C2([H])[H])=C1[H])C(F)(F)F
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C(C([H])=C2C([H])([H])[H])C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1C([H])([H])[H])C(F)(F)F
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NOC(=N1)C1(C([H])([H])[H])C([H])([H])OC1([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C1=C([H])N=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=NN=C1[H]
[H]N(C(=O)C([H])([H])SC([H])([H])C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H]
COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CN=C(N)N=C3N)C2=O)C=C1
[H]C1=C(N=NC(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2C(=O)C([H])=C(OC2=C([H])C(OC([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=N[C@@]([H])(C2=C([H])C([H])=C([H])S2)C(C(=O)OC([H])([H])[H])=C(N1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H]
[H]C1=NC([H])=C2N1C1=C([H])C([H])=C([H])C([H])=C1C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C2C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
COC1=C(C=CC=C1)C1=CN2C(=N1)N=C(C)C(CN)=C2C1=CC=C(Cl)C(F)=C1
[H]OC([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C1=C(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=NO1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]OC(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(N=C([H])N=C3OC2(C([H])([H])[H])C([H])([H])[H])N([H])[H])C([H])([H])C1([H])[H]
[H]SC1=NN=C(S1)N([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C(=O)C([H])([H])[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=NN=C1[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(F)F)C([H])=C1[H]
[H]N1N(C2=NC(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(N([H])C1=O)C([H])([H])[H]
[H]N(C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(=NO2)C([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]1(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=NC(N([H])C([H])([H])[H])=C2[H])C(F)=C1[H]
[H]N(C(=O)C1=NC(=NC(=C1[H])C1=C([H])C([H])=C(O1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]O[C@]1(C2=C(C3=C(N2[H])C([H])=C([H])C(Cl)=C3Cl)C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(Cl)C(=C([H])S1)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
OC(C1=CC=NC=C1)C1=CC2=C3N(CCC3=C1)C(=O)CC2
[H]C1=NC(Cl)=C([H])C([H])=C1C([H])([H])N1C(=C(C#N)C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C(=C([H])N3[H])C([H])([H])[H])C2=C1[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([O-])=O
[H]N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]OC1=C([H])C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C(C(=O)N([H])[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C#N)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(\C([H])=C(/C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C2=C([H])C([H])=C([H])C([H])=N2)=C([H])C([H])=C1[H]
[H]N(C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C(N2[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1N=C2N(C1=S)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=[N+](C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)OC([H])([H])[C@@]1([H])O[C@@]([H])(C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C(=O)C([H])([H])[H]
[H]C1=NN(C2=NC([H])=NC(OC3([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C(C([H])=C1F)S(=O)(=O)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1([H])[H]
[H]N(C1=C([H])C(=NC(OC2=C(C([H])=C(Cl)C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C([H])C(=C1C1=C2N=C(C(F)=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1C([H])([H])[H]
[H]C1=NC2=C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H]
[H]O[C@](C1=C([H])C2=C([H])C(Cl)=C(C([H])=C2N1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])SC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1N=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])N=C12)C(=O)C1=C([H])C([H])=C([H])O1
[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)C1=C([H])[C@@]3([H])C(=O)[C@@]4(OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(C3([H])[H])[C@]14O2)C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(OC(=O)C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=C2C([H])=C(OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C([H])C2=NC([H])=N1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C(F)=C2C(=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C2C([H])=C(N([H])C2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[C@]([H])(C1=C([H])C(\C([H])=C(/[H])C2=NC3=C([H])C(Cl)=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C(O[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(C([H])=C(N([H])C2=C([H])C([H])=C(N([H])C3=NC(Cl)=NC(Cl)=N3)C([H])=C2[H])C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1C2=O)S([O-])(=O)=O
[H]N([H])C(N([H])C([H])([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N([H])C(N([H])[H])=[N+]([H])[H])=[N+]([H])[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]C1=C(SC2=C1C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])=C([H])N=C2[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C([H])=C(C([H])=C2[H])[C@]([H])(C2=C([H])C(OC([H])(F)F)=C(OC([H])(F)F)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=[N+]([O-])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]13C([H])([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@]21C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C3([H])[H]
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[H][C@@]12CCC3C4CCC(C(C)CCC(O)=O)[C@@]4(C)C(O)CC3[C@]1(C)CCC(O)C2
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[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])C(=O)N([H])[H])C([H])([H])C1([H])[H])C2=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C([H])C([H])=C1F
[H]C1=C([H])C(=C([H])C([H])=C1SC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]C1=NN=C2N1C1=C([H])C(=C(C([H])=C1N=C(C1=C([H])C([H])=C(C([H])=C1[H])N1C(=NC3=C1C([H])=C([H])N=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C2\C(=O)C3=C(O[H])C([H])=C(O[H])C([H])=C3OC2([H])[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])\C(=N\C1=C([H])C([H])=C([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N2C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(N=C(C([H])=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])[C@]1([H])O[C@@]2(C3=C(C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C([H])C(C#N)=C([H])C([H])=C12)C([H])([H])C([H])([H])[C@]1(N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(=O)N2C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])C1=O
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=N[C@@]([H])(C2=NN=C(N2C2=C1[C@]1([H])C([H])([H])C([H])([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])S2)C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])[H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=NC(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2N=NN(C2=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC2=C(C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]3([H])C4=C(C([H])=C([H])C(C#CC5=C([H])C([H])=C([H])C([H])=C5[H])=C4[H])C([H])([H])[C@]23[H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])=NC2=C1N=C(N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C(=O)N([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])SC([H])([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(OC([H])=C2C([H])([H])N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=N1
[H]C1=C2N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C2=C1N(C(=O)C([H])=C2C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C(C1=NC(=C([H])S1)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C(C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N1C(=O)C([H])([H])OC2=C1C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C(N=C([H])O2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
NC(=O)C(=O)N1CCC2=C(C1)C(=NN2CCCN1CCSCC1)C1=CC(C#CC2=CC=C(CNCC3=CC=C(Cl)C=C3)C=C2)=C(Cl)C=C1
[H]N(C(=O)C1=C([H])C([H])=C(C(OC2=NC([H])=C([H])C([H])=C2C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=C(\C([H])=C(/[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C(=C([H])S2)C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2O[C@@]3(C([H])([H])N(C([H])([H])[C@]([H])(O[H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])S(=O)(=O)C4=C(C([H])=C([H])C([H])=C4C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2=C1[H]
[H]C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])[C@]2([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])N=C3[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2N=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]N1C([H])=C(N=C1C1=NN(N=N1)C1=C([H])C(F)=C([H])C(C#N)=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N1N(C(=C(C1=O)C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])N=C1[H]
[H]N([H])C1=NC([H])=C(N=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]C1=C([H])N=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C(N(C2=NC(=C([H])C(=N2)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C([H])=C1C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(I)C([H])=C1[H])C3([H])[H]
[H]N1C([H])([H])C2=C(N3N=C(C(=C3N=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=NOC([H])=N2)C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C([H])N=C1N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NC2=C(N1[H])C([H])=C(Cl)C(Cl)=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=O)C([H])=C1[H]
[H]N([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])C([H])([H])OC([H])([H])[H])[C@@]2([H])C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]N([H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])N2[H])C1=C([H])SC([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C1=NC(=NO1)C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C([H])C(OC([H])([H])[H])=NC(=N1)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1N=C(C(=C1[H])C1=C([H])C([H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C2=C([H])C(=C([H])C([H])=C2OC([H])([H])C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@]2([H])N(C3=C4C([H])=C([H])C(=NC4=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C(C([H])=C([H])C([H])=C3F)C([H])([H])[H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C([H])=C(C([H])=C2[H])C2=C(N=C(N2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(F)C([H])=C(F)C([H])=C2[H])N1S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(OC1([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C1=NC([H])=C(C2=C1C(=C([H])S2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H])C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
NC(=O)C1=C(NC(=C1)C1=C(F)C=NC(N)=N1)C1=CC=CC=C1
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(C([H])=C23)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N([H])C2=C1C(Br)=C([H])C([H])=C2[H])C1([H])C([H])([H])C1([H])[H]
[H]N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C(Cl)=C([H])C([H])=C2[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])([S@+]([O-])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(SC2=NN3C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2(C3=C([H])C(OC(=O)[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]5(C6=C(C([H])=C([H])C(O[H])=C6[H])C([H])([H])C([H])([H])[C@@]45[H])C([H])([H])[H])=C([H])C([H])=C3C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H]
[H]OC(=O)C(=C(/C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])\C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C#N)C([H])([H])C([H])([H])N1C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(\[H])=C(/[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H]
[H]C1=C([H])C(OC2=C([H])N=C(C([H])=N2)C2=NN=C(N2C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(/C1=C([H])C(=C([H])C(=C1OC([H])([H])C([H])([H])F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])/C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NC(=NS1)C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NO2)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(I)=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C1=NC([H])=NC(=C1[H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])OC([H])([H])[H]
[H]C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C(O1)C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=N1)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C([H])([H])C2=C(OC(F)(F)F)C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SS[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=NN(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(SC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C([H])([H])[C@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H]
[H]N(C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C1([H])[H])C([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(=C(O[H])C([H])=C2[H])[C@]23C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C4([H])[H])C2([H])[H])C3([H])[H])C([H])=C1[H]
[H]N(\N=C(/[H])C1=C(C([H])=C([H])S1)C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC1=O
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(F)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C#CC3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=S)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=NC([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])=C2[H])C(=C([H])C1=O)C1=NC([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(C#CC3=C([H])C([H])=C([H])C(=N3)C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
CC1CCN(CC1)c1nc(Nc2cc(n[nH]2)C2CC2)c2ccccc2n1
[H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC1=O
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[H]N(C(=O)N([H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
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[H]N(C(=O)C([H])([H])C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1Cl)C(F)(F)F
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[H]N([H])S(=O)(=O)C1=C([H])C(Br)=C(N([H])C([H])([H])C2=C([H])C(=O)OC3=C2C([H])=C([H])C(Cl)=C3[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C3=O)C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
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[H]N(\N=C(/[H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])=C([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])=C2[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C2=C(OC3([H])C([H])([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C([H])([H])C3([H])[H])N=C([H])C([H])=N2)C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)C([H])([H])[H]
[H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C1=C(C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])C(=O)C(=O)N1[C@@]2([H])C(=O)N3C([H])([H])C([H])([H])C4=C(C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C4[H])[C@]3([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C1=C([H])C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(O[C@]([H])(C2=C(Cl)C([H])=C([H])C(F)=C2Cl)C([H])([H])[H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(O[C@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C(C2=NC([H])=C([H])C([H])=C2N1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]2([H])O[C@@]([H])(O[C@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H]
[H]N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N([H])C1=C(SC(=S)N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])=C(OC([H])(F)F)C(OC([H])(F)F)=C1[H])C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N([H])C(C2=C([H])C([H])=C(C([H])=C2[H])N2C3=NC([H])=C([H])C([H])=C3N=C2C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1\C(=N\C(=O)C2=C([H])C([H])=C(S2)C2=C([H])N([H])N=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N([H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C2=C([H])N=C(C([H])=C2C([H])=C1[H])C(=O)N([H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(Cl)C(=C1[H])C(F)(F)F
[H]C1=C([H])C2(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC(=O)C1=C([H])\C(=N\C(\S[H])=N\C([H])([H])C([H])([H])[C@@]([H])(OC(=O)[C@@]2([H])N(C(=O)C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C1=C1C2=C(OC3=C1C([H])=C([H])C(O[H])=C3[H])C([H])=C(O[H])C([H])=C2[H]
[H]N(C1=C(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])C2=C(F)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]C1=C([H])C(=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@]11O[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C3=C(C(=NN3C3=C([H])C4=C(ON=C4N([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OP(=O)(O[H])C([H])(C([H])([H])SC1=NC([H])=C([H])N1[H])P(=O)(O[H])O[H]
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[H]OC1=C([H])\C(=N\C2=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=NC([H])=N2)C(=O)C(Cl)=C1Cl
[H]OC([H])([H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C2=C1C1=C(N([H])C(C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C(C(=O)C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H])S(=O)(=O)C([H])([H])[H]
OC1(CC2=CC=CC=C2)CCN(C1)C1=CC(Cl)=C(C=C1)C#N
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(SC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H]
[H]C1=NC(=C(C([H])=C1[H])C1=NC(=C2N1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1N=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]\C(C1=C([H])C([H])=C(Cl)S1)=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
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[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C([H])C(F)=C([H])C(F)=C1[H]
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[H]C1=C([H])C([H])=C([H])C(=N1)C1=NC(=C(S1)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
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[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]N(\N=C(\C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C(=O)N([H])C1=NN([H])C(=S)S1
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2=O
[H]C1=C([H])C(=C2C(=O)N(C([H])([H])OC3=C([H])C(Cl)=C(C(=O)OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C(Cl)=C3[H])S(=O)(=O)C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C(N=C1[C@@]1([H])C([H])([H])[C@]3([H])C([H])=C([H])[C@@]1([H])C3([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
COC1=CC=C(C=C1)C1=C(C2=C(NC[C@@H]3CCCO3)N=CN=C2N1)C1=CC=CC=C1
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[H]N(C1=C([H])C([H])=C(N=N1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@](C([H])([H])[H])(C1([H])[H])C([H])([H])[C@@](C([H])([H])[H])(C3([H])[H])C2([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])OC3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])C1([H])[H]
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[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
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COC1=CC=C(NC2=C(C(C)=NN2C2=C(C)C=CC=C2)C2=CC3=C(OCO3)C=C2)C(=C1)C(O)=O
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Cl.CCCCN1CCC2=C(CC3=CC=CC=C23)C1
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[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC(=C(S1)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NN([H])C2=NC(=C(Br)C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]C1=C([H])C(C#N)=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CC1=CC(C[C@@H]2CNC[C@@H]2OCCNC2CC2C2=CC=CC(Cl)=C2)=NC(N)=C1
[H]N([H])C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C(N([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])N1C(SC([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2F)=NC2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C2N(C3=C(C2=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C([H])([H])C3([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H]
[H]N(C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])=C([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C2=C([H])C([H])=C([H])C(\C([H])=C(/[H])C3=NC4=C([H])C(Cl)=C([H])C([H])=C4C([H])=C3[H])=C2C([H])=C1[H])S(=O)(=O)C(F)(F)F
[H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])[H]
[H]N([H])C1=NC(=NC2=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(\[H])=C(/[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])[C@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]N1C(=NC(=C1C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])C(F)(F)F)C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)O[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])N(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(Br)C(=NC2=C(C([H])=NN12)C1=C([H])N(N=C1[H])C([H])([H])[H])[C@]1([H])SC([H])([H])C([H])([H])N([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(N=C(N=C12)C#N)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(F)C(F)=C(F)C(F)=C1F
[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])P(=O)(O[H])O[H]
[H]N1C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])N=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C(S1)C1=NN=C2S\C(=C(\[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(=NN12)C1=C([H])C(F)=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])[H]
[H]C1=C(OC2=C1C([H])=C([H])C(=C2[H])C(F)(F)F)C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=NC2=NC(=NC(N([H])[H])=C2N=C1[H])N([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(N=[N+]=[N-])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C(=S)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])ON=C(C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3[H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C(=NC([H])=N2)N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(=C1F)C(F)(F)F
CS(=O)(=O)CCNC(=O)C1=CC2=C(CCC3=C(C=CC(NC4=C(F)C=C(F)C=C4)=C3)C2=O)C=C1
[H]N(\C(=N/S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#CC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C(=C1[H])[N+]([O-])=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@@]2([H])C(=O)C3=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(F)C([H])=C(F)C(=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[N@+]([H])(C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C#N)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
CCCCCN1C=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C(=O)C2=C1SC(C)=C2C
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C2C(=C1[H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1Br)C([H])(N1N=C([H])N=C1[H])C1=C([H])C(Br)=C(OS(=O)(=O)N([H])[H])C([H])=C1[H]
[H]\C(=N/C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C(C2=C([H])C([H])=C([H])C([H])=C2F)=C1C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=NN=C(O2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
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[H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=NN(\C(S1)=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C1([H])C([H])([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])SC([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
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[H]N1C(=O)N(C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])N([H])C(=O)C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])[C@@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(SC([H])([H])[H])=NC(N([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1N(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=NC([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C(=O)N([H])N([H])C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)[C@]([H])(N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])\C(=C(/[H])C([H])([H])[H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H]
COC1=CC=CC(OC)=C1CNC(=O)NC1=CC=C(C=C1)C1=CNN=C1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(F)=C(OC2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(P([O-])([O-])=O)S([O-])(=O)=O)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N[H])N([H])[H]
[H]N(\N=N\C1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(F)=C3[H])C([H])([H])C1([H])[H]
[H]N1C(=NC2=C1C([H])([H])N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N([H])C1=O
[H]N(C(=O)C([H])([H])N1N=C(C2=NC3=C(N2[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(I)=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C2C([H])=C1[H]
[H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])C([H])=C([H])[H])\C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OP([O-])(=O)OC([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C1[H])[C@@]1([H])O[C@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C(=O)C([H])([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N(C1=NC(=NC(=N1)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H]
[H]N1C(=NC2=C([H])C(F)=C([H])C([H])=C12)C([H])([H])C1=NC(=C([H])C(=O)N1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])C(=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@](OC(=O)C([H])([H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=NC(=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C([H])([H])[H]
[H]OC(=O)C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2N1[H])C([H])([H])C(=O)OC([H])([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(SS[C@@]([H])(C([H])([H])C(=O)OC([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C1C([H])([H])C([H])([H])N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])=C(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]OC(=O)C1=C([H])C(OC([H])([H])[H])=C(O[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])C([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])C2([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H]
[H]OC(C1=NC([H])=C(C([H])=C1[H])N(C(=S)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])(C(F)(F)F)C(F)(F)F
[H]N([H])C(=O)C([H])([H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H]
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[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1F
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[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(OC2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N([H])C1=NOC2=C1C([H])=C(C([H])=C2[H])N1N=C(C2=C1C(=O)N(C([H])=N2)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]OC1=C([H])C(F)=C(C([H])=C1[H])[C@]1([H])OC(C([H])([H])[H])(C([H])([H])[H])[C@]2(O[H])C([H])([H])C([H])=C(C([H])([H])[H])[C@@]1([H])C2([H])[H]
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[H]O[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC2=NC(OC3=C([H])C(=C([H])C([H])=C3[H])C(=N[H])N([H])[H])=C(F)C(=C2F)C([H])([H])[H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N(C(=O)C1=C([H])C(=NN1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N(C1=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C2=C(C([H])=NN2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC(Cl)=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]N1C2=C(N=C(N=C2C([H])=C1[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Br)O1)C1=C([H])C2=C(N([H])C(=O)N2[H])C([H])=C1[H]
[H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C2=C([H])C(N([H])C3=NC(=C([H])C([H])=N3)C3=C([H])C(OC([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])N(C([H])([H])[H])C2([H])[H])=C([H])C([H])=C3[H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]OC1=C([H])C([H])=C(C(N([H])C2=NC(=NC([H])=C2[H])N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N([H])[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])C(=O)N(C2=C([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]2(C(=O)OC([H])([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]ON([H])C(=O)[C@@](O[H])(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(N=C1[C@]1([H])N([H])[C@]([H])(C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[Na+].CO[C@H](COS([O-])(=O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H]1[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)N(C)C(=O)[C@H](CC2=CC=CC=C2)N2[C@H](O)CC[C@H](NC(=O)\C(NC1=O)=C\C)C2=O)C(C)C
COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC=CN=C3C3=C(C)N(C)N=C3C)C2=O)C=C1
[H]\C(=C1\SC(=NC1=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C2C(=NC(=N1)N([H])[H])N([H])C(=C2SC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])[H]
[H]C1=NC([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C(C#N)C(=O)N(C([H])=C2[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(ON=C2C2=C([H])C(F)=C(O[H])C([H])=C2[H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(C([H])=C3N2C([H])([H])C([H])([H])[C@]([H])(N([H])C3=O)C([H])([H])[H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(=C([H])N1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])SSC1([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C3=C(C([H])=C2[H])N2C(=C(C(=O)C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C(C([H])=C2N([H])C(=O)C([H])([H])C(=NC2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F
COCC1=C(O)C=CC(OCC(O)CNC2CCN(CC2)C2=NC=NC3=C2C(=CS3)C2=CC=CC=C2)=C1
[H]N1C(=S)N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])(OC([H])([H])[H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=N1)C(=O)N1C(=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@]2([H])OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
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[H]N(C(=O)N([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2N1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S([O-])(=O)=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C(=O)C3=NC4=C([H])C([H])=C([H])C([H])=C4N3C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])N(C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F)[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(C3=C([H])N=C(OC([H])([H])[H])C([H])=N3)=C2C1([H])[H]
[H]OC(=O)[C@@]([H])(OC1=NC(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=N1)C(OC([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1F)C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C(O[H])C([H])=C([H])C3=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=C([H])N(N=C1[H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=NC2=C(C([H])=C1[H])C([H])=C(C([H])=C2[H])C1=NN=C(O1)SC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C(F)(F)F
[H]N([H])C1=NC2=NC([H])=C(N=C2C(=N1)N([H])[H])C([H])([H])SC1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC1=C(OC([H])([H])[H])C(C(=O)N([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C(Cl)C(Br)=C1[H]
[H]OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])(OC2=C(N=C([H])C([H])=N2)C2=C([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])SSC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=O)C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N([H])C([H])=N1
[H]OC(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C4=C([H])N=C(C([H])=C4[H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C(C(=O)OC([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3S2(=O)=O)C(Cl)=C([H])C([H])=C1[H]
[H]OC1([H])C2=C(OC([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C1=C2OC2(OC([H])([H])[H])C([H])(OC([H])([H])[H])C(=O)C3=C(OC([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])OC([H])([H])[H])C12OC([H])([H])[H]
[H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(Cl)C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(O[C@]4([H])C5=C(C([H])=C([H])C([H])=C5[H])C([H])([H])C4([H])[H])C([H])=C3[H])C2=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])OC3=C([H])C([H])=C4N=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]OC1=C(N(N=C1C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]N([H])C1=NC2=C(N([H])S(=O)(=O)C3=C([H])C(Br)=C(Br)S3)C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C1=NC([H])=NC2=C1C([H])=C(N=C2[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C([H])=C(S1)C1=C([H])C(N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3N=C2O1
[H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])N([H])C([H])([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C(C(=N1)C([H])([H])[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=N1)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=NN2C(N=C([H])C([H])=C2C2=C([H])C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])=C(OC([H])(F)F)C([H])=C2[H])=C1[H])C([H])([H])C([H])([H])C#N
[H]OC(=O)C(\[H])=C(/[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C(\[H])=C(/[H])C1=C(O[H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C3C(=NC([H])=C2[H])N([H])C([H])=C13
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])C([H])([H])C([H])([H])[C@@]21C([H])([H])C([H])=C([H])[H]
[H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C(F)C([H])=C3[H])C2=C(N=C1[H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(N(C(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])O2)C([H])([H])C([H])([H])OC([H])([H])[H])C(=O)N([H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C3=C(SC2=C1[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C([H])([H])C([H])([H])[N+]([O-])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C5=C(C([H])=C([H])C([H])=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]23[H])C1([H])[H]
[H]O[C@@]1([H])OC(=O)C(Br)=C1C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(F)C([H])=N2)C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C(F)=C2F)C1([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C(ON=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])N2C([H])=C1C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(C(=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=C1C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C2([H])C([H])([H])C([H])([H])N(C3=C(OC(F)(F)F)C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C(=NN12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(C([H])=C23)C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(Cl)C([H])=C([H])C(=C1[H])C1=C2N=C([H])C3=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C3([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2F)C([H])([H])C2=NN([H])C(=O)C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=NC(I)=C(OC([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])S[C@]1([H])C2=C(OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(Cl)=C2Cl)C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]N=C(N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C(=O)N(SC2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C2=C3C(=O)N(C(=O)C3=C([H])C([H])=C2[H])[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C(=C(\[H])C1=C([H])C([H])=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])\C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=C3N=C([H])N([H])C3=NC(=N2)N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1O[H])C([H])([H])[C@@]([H])(O[C@@]2([H])C([H])([H])N([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(SC(=C2OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H]
[H]C1=C([H])N2C([H])=C(C([H])=C([H])C2=N1)C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])[C@]12[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[N@]2C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])OC([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]O[C@]1([H])C2=C([H])C([H])=C(O[C@@]([H])(C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])[H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OP(=O)(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])S(=O)(=O)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1(C([H])([H])C2=C([H])C(=C(C([H])=C2[H])N2C(=O)C3=C(OC([H])([H])C([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C4C(OC([H])([H])C([H])([H])[H])=C3C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]1([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C2=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3OC2=O)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])SC(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2N=C1Cl
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N([H])[C@@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(Cl)S2)[C@@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=C([H])C([H])=C([H])C1=O
[H]OC1=NC(=NC2=C1C([H])=C([H])C([H])=C2[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C3C([H])=C(SC3=C([H])N=C2[H])C2=NN([H])N=N2)C([H])=C1[H]
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C(=O)[C@@]1([H])C2([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=NC([H])=C([H])N2C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])N(N=C4[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C21)C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C2OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C(=O)C2=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]OC([H])([H])C1=C([H])N=C([H])C(=C1[H])C([H])([H])N1C(=C(C#N)C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]N1[C@]2([H])C3=C(N(C4=C3C([H])=C(C([H])=C4C([H])([H])[H])S(=O)(=O)C3=C([H])C(Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]N1N=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=NC(=NO1)C1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O\N=C(\C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C(Br)=C([H])C2=C1OC(=C([H])C2=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
FC1=CC=C2NC=C(CCCSC#N)C2=C1
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C(N=C(N=C1[H])C([H])([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C3=C(C([H])=C2S1)C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C([H])([H])[C@@]32C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=N1
[H]N1C([H])=NC2=C([H])C([H])=C([H])C(Cl)=C2C1=O
[H]N1C2=C([H])C([H])=C(C([H])=C2C(OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])O1)C1=C([H])C(F)=C([H])C(C#N)=C1[H]
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[H]N(C(=O)C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@]1([H])C2=C(SC(=C2[H])S(=O)(=O)N([H])[H])S(=O)(=O)N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H]
[H]N(C1=NC(=NC(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1F)C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(Cl)=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]2([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]1(C(=O)OC([H])([H])[H])C([H])([H])C3([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]1([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C3([H])[H]
[H]N1C(=O)N(N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C([H])([H])C1=O
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N(C(=O)C1=C([H])C2=C(N=C(S2)N([H])C2=NC([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])SC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
OC1=CC=C2OS(=O)(=O)C=CC2=C1
[H]OC(=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])C2=C([H])C3=C(O2)C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])O[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C(=C(/[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])C4=C([H])C(=C([H])C([H])=C4[H])[N+]([O-])=O)[C@]([H])(OC([H])([H])[H])C3([H])[H])\C([H])([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H]
[H]OC1=C([H])C([H])=C(N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2O[H])P(=O)(O[H])O[H])C([H])=C1[H]
[H]N(N1N=C([H])C(=C1[H])[N+]([O-])=O)C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1(N([H])S(=O)(=O)N2C([H])([H])C3=C(N4C([H])=C([H])C(Cl)=C([H])C4=N3)C2([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[H]
[H]C1=C(ON=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C(N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])=C(C#N)C#N
[H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C([H])=C(F)C(Cl)=C3[H])C2=C1[H]
[H]OC1=C(OC([H])([H])[H])C(C(=O)N([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=NC3=C(N=C(N=C3N=C2[H])N([H])[H])N([H])[H])C([H])=C1[H])C([H])([H])P(=O)(O[H])O[H]
[H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(SC(F)=C4F)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=N\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C(=O)N1C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])N(C2=C(C([H])=C3N=C(N=NC3=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=C([H])C([H])=C([H])C([H])=N1
[H]N1N=NC(=N1)C([H])([H])OC1=C([H])C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@](C(=O)N([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C(C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]12[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]