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[H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])C(=O)N3C([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C1=O
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])[C@]1([H])ON=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])N=C2N([H])C2=C1C([H])=C(Cl)C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]([H])(O[C@@]([H])(O[C@]2([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@@](OC([H])([H])[H])(C([H])([H])[H])C3([H])[H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2(O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])O[H])C([H])([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])SC([H])([H])C1([H])[H]
[H]N(C1=NC(=NN1C(=O)C([H])([H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C([H])C(F)=C(F)C([H])=C2N2C([H])=NN=C12)C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(O[C@]2([H])C3=C([H])C([H])=C([H])C([H])=C3[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])=C1[H]
[H]O[C@@]1(C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C([H])N([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2C(N([H])C(=O)\C2=C(\[H])C2=C(OC([H])([H])[H])C([H])=C([H])N2[H])=C([H])C([H])=C1[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C2C3=C(N1[H])C([H])=C([H])C([H])=C3C(=O)N([H])C([H])([H])C2([H])[H]
[H]N([H])[C@]([H])(C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=NN(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN(C(=C1[H])C1=C2N(C([H])=C(C2=C([H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H]N1N=NC(=N1)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H]
[H]OC([H])([H])C(=O)[C@@]1(OC(=O)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3(F)[C@@]([H])(O[H])C([H])([H])[C@]12C([H])([H])[H]
[H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(OC([H])([H])C([H])([H])OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C2[H]
CCCCN(C(=O)C1=CC=C(C=C1)C(F)(F)F)C1=NN=C(S1)C1=CC=C(CN2CCNCC2)C=C1
[H]C#C[C@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C#N)C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC1=C(C(=NN1C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]\C(C#CC([H])([H])C([H])([H])C([H])([H])[H])=C1\SC2=NC3=C([H])C([H])=C([H])C([H])=C3N2C1([H])[H]
[H]N(C1=NC(N([H])C([H])([H])[H])=C(C([H])=N1)C(F)(F)F)C1=C([H])C(Cl)=C(C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C(OC2=C([H])N=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C([H])C(O[C@]([H])(C(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[H])=C12
[H]OC([H])([H])C(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])N([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CNC(=O)N\C=C\C1=C(OC)C=CC=C1
[H]N([H])C(=O)C1=C(N([H])[H])C2=C(S1)N=C(C([H])=C2C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=N\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C(=O)N1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(C1=C([H])C([H])=C([H])N=C1[H])(C1=C([H])C([H])=C([H])N=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C(=O)N([H])C(=O)[C@@]2(N(C(=O)C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O
[H]N(C(=O)C1=C(C([H])=C([H])S1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3F)C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C1=C([H])C([H])=C([H])C(OC([H])([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])O1)C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C#CC([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])SC(=O)[C@@]1([H])N(C(=O)C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C([H])C2=C1N1C(=N2)C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H]
[H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(C(=C([H])N=C1C([H])([H])[H])C([H])([H])O[H])C([H])([H])N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C1=C(O[H])C(=NC([H])=C1C([H])([H])O[H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])C([H])([H])C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N([H])C1=NC(=C2C([H])=C(C3=C([H])N([H])N=C3[H])C(=O)N(C2=N1)C1([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])[H])C([H])([H])[H]
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[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])P([O-])([O-])=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
CSCC[C@@H](CO)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
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[H]OC(=O)C([H])([H])C1=NN(C(=O)C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C(F)(F)F
[H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(F)C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F
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ClC1=C(Cl)C=C(C=C1)C1CCCCNC1
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[H]N([H])C(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]OC1=C(C(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C1=NC(N([H])[H])=C(C#N)C(=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(\C([H])=C2/N([H])\C(=N\C([H])([H])[H])N([H])C2=O)C2=C1C([H])=C(Br)C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N([H])C1=C(OC([H])([H])[H])C([H])=C(Cl)C(=C1C([H])([H])[S@@](=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C2C(=C1[H])[C@]1([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C2C(C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]OC([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C3=C2N(C2=C3C3=C(C(=O)N([H])C3=O)C3=C2N([H])C2=C3C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=C([H])C(=NN4C([H])([H])C([H])([H])[H])C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])[H])C1=C([H])SC([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C2=C1OC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C3C1=C([H])C([H])=C(N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C3=C([H])C([H])=C2[H]
[H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C#N)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(/C([H])([H])[H])[C@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]C1=C([H])C([H])=C2C(\N=C3/OC([H])([H])C4(C([H])([H])N3C(=S)SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C(F)C2=C1[H]
[H]N([H])C(=O)[C@@]([H])(N1C(=O)[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C(O3)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N([H])C2=C1C(F)=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN=NN1[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H]
[H]O\C(\C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])F)C(OC([H])([H])[H])=C1[H])=C(\[H])C(=O)C([H])([H])[H]
[H]N([H])C(=O)C1=C(O[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C(S1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2C(Br)=C(O[H])C([H])=C([H])C2=C1[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N(C1=C(Br)C(=O)N(N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C4([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3N([H])C2=N1
[H]N([H])C1=NC([H])=NC(OC2=C([H])C(Cl)=C(N([H])C(=O)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C1\C([H])=N\OC([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC1=C([H])C([H])=C2C(=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H]
[H]ON(\C([H])=C(\[H])C(=O)C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(C1=C([H])C(=C([H])C2=NC([H])=C(N=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C([H])=C([H])C(F)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N[H])N([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2I)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C2=NC([H])=C([H])C([H])=C12)C1=C(C2=NC([H])=C([H])O2)C(Br)=C([H])S1
[H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=NC([H])=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C1(C2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2Cl)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)O\N=C(/[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C(Cl)C([H])=C(OC([H])([H])[H])C(=C1[H])C1=NC(=NN1C([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C([H])([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=NC(=O)N([H])C(=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])[C@]1([H])O[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(F)=C([H])C(=C1[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C#N)C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]12[H]
CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C2=COC=C2)C=C1
[H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=C(C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C1C([H])=C([H])N2C([H])([H])[H]
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[H][C@@]1(CCCCN1)[C@H](C(=O)OC)C1=CC(Cl)=CC(Cl)=C1
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[H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H]
[H]N(C1=C2C([H])=NN(C2=NC(Cl)=N1)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=NC([H])=NC2=C1C([H])=C(C([H])=C2[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])C#C[H]
[H]N1N=C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C1C(=O)N(C2=O)C1=C([H])C([H])=C([H])C([H])=C1F
[H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C(=C([H])C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C(=O)[C@@]21[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C1=O
[H]N1N=NC(=N1)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3SC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)OC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC(=NC(=C2C([H])([H])N([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=NC(=C1[H])C1=C([H])C(Cl)=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(SC3=NN4C([H])=C([H])C([H])=C4C(=N3)N([H])C3=NN([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])[C@@]1([H])C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])N=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C(F)(F)F)C([H])=C([H])C([H])=C2[H]
[H]N([H])C1=C([H])C(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C([H])([H])C1([H])[H]
CC(C)C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NC(CC1=CC=CC=C1)C(=O)C(=O)NCCCN1C=NC2=C(N)N=CN=C12
[H]N([H])C(=O)C1=C(N([H])C(=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(C(=O)OC3=C([H])C([H])=C([H])C([H])=C3[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])[H]
[H]\C(=C(\[H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=O)N=C(SC([H])([H])C(=O)N2C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(OC(=O)OC([H])([H])C3=C(Br)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N([H])C1=C([H])C(=NN1C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC1=C(I)C([H])=C(\C([H])=C2\SC(=O)N([H])C2=O)C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C1=C(N=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]\C(C1=C([H])C(Cl)=C(I)C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C3([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C2=C3C([H])=C(N(C(O[H])=C3N=C12)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])N1C(=O)C([H])([H])C(=O)[C@]1([H])C1=C([H])C([H])=C([H])C(F)=C1F
CC1=CC=CC(C(=O)N2CCC[C@@H](C2)C2=NC(=NO2)C2=CC=CC=C2)=C1Cl
[H]N([H])C([H])([H])C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N(C(=O)C([H])([H])[H])C([H])([H])C(\[H])=C(/C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H]
[H]N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C([H])C(=C([H])N3[H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C2=C1[H]
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C(OC([H])([H])C(=O)OC([H])([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN=NN1[H])C(F)(F)N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(N1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N([H])\C(=N/C(=O)C4=C([H])C(C#N)=C([H])C(F)=C4[H])N(C3=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C(=O)N(C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[C@@]1(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N=N1)C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N2C(=O)N(C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])N=C1Cl
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=N2)C(=O)N([H])C2=C([H])C([H])=C(C(N([H])C3=NC([H])=C(S3)C3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(C2=C([H])C(N([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N(C(=O)[C@@]([H])(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC1=C([H])C(O[H])=C(C2=C1C(=O)C([H])=C(O2)SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H]
[H]ON([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC#CC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C(OC([H])([H])[H])=NN2N=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC([H])([H])C1=C(N(N=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C(F)(F)F
[H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C22C([H])([H])C3(OC12C([H])([H])C3([H])[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])O1)C([H])([H])C([H])([H])C#N
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F
[H]N(C(=O)C1=C([H])C([H])=C2C(=O)N(C(=O)N([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H]
[H]OC(=O)C1=C(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2F)C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(C#N)=C([H])C([H])=C1C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H]
[H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=NN=NN3C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N(C(=O)C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(OC(=C([H])C1=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=O)N(C2=C1N=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=NN=C(O2)C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(N([H])C(=O)[C@@]1([H])N3C(=O)C([H])([H])N(C([H])([H])[C@]3([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O
[H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C2=NC([H])=C([H])N=C2[H])C([H])([H])C3([H])[H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(\C([H])=C(/[H])C3=C([H])N=C([H])C(C#N)=C3N([H])C3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])=C([H])N([H])C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@](C2=C(F)C([H])=C([H])C(F)=C2[H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[C@@]2([H])N(C(=O)C([H])([H])C3=C([H])C4=C(N=C(O4)N([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])[C@@]([H])(F)C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F)[C@@]([H])(C1=NC2=C([H])C([H])=C([H])N=C2C(=O)N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C1=NC([H])=C([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@]1(C(=O)OC([H])([H])[H])C([H])([H])[C@@]2([H])O[C@@]1(N1C3=C([H])C([H])=C(C([H])=C3C3=C1C1=C(C4=C(C([H])=C([H])C(=C4[H])C([H])([H])SC([H])([H])C([H])([H])C([H])([H])[H])N21)C1=C3C([H])([H])N([H])C1=O)C([H])([H])SC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]1(OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])O1)C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1N([H])S(=O)(=O)C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C(O[H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=C(S2)C([H])([H])[H])C1=S)C1=NN([H])C(=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=NOC2=C1C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])N=C1[H])C2([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C#N)[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H]
[H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[C@@]1([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N([H])C1=NC(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])N([H])C([H])([H])C(F)(F)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=NC2=C([H])C(N([H])C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1[H]