[H]N([H])C1=C([H])C([H])=C2C(=C1[H])N(C(=C2C(=O)N([H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(C2=NN(C(=C2C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2Cl)=C1C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2O[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])SC(=N1)N([H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1(N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C3C(=NC([H])=N2)N([H])C([H])=C13)C(=O)OC([H])([H])C([H])([H])[H] [H]N1C([H])=NC(=C1C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=NC([H])=C2C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NC(=C([H])C([H])=C1[H])C1=C([H])N([H])N=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C(\C([H])=C(/[H])C3=NC4=C(C([H])=C3[H])C([H])=C(Cl)C([H])=C4[H])=C2C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C2=C(N=C1[H])C1(C(=O)N2[H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C(=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])OC3=C([H])C([H])=C(C([H])=C3OC2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])C1=C([H])C([H])=C2OC3=C([H])C(=C([H])C([H])=C3C#N)C([H])([H])N3C([H])=NC([H])=C3C([H])([H])[N@]3C([H])([H])C(=O)N(C([H])([H])C3([H])[H])C([H])([H])C1=C2[H] [H]N([H])C1=NC(Cl)=C([H])C(=N1)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=NC([H])=C2C([H])=C(C(=NC2=N1)N([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C(Cl)=C([H])C(F)=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)OC2([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(F)=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C([H])=C1OC2=C([H])C([H])=C(F)C([H])=C2C2=C1C1=C(N([H])C(C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H] [H]OC1=C([H])C(O[H])=C2C(=O)\C(OC2=C1[H])=C(/[H])C1=C([H])N(C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C(C([H])=C2[C@@](OC([H])([H])C1=O)(C1=C([H])C([H])=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(C#N)=C1[H] [H]N(C(=O)C([H])([H])C1=NC2=C(N1[H])C(=C([H])C([H])=C2[H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(OC2=NC(OC3=C([H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C(F)C(N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2F)C([H])=C([H])C(N([H])[H])=C1[H] [H]OC(=O)[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@@]2([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C(=O)O[C@]([H])(C3=C([H])OC([H])=C3[H])C([H])([H])[C@]21C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N([H])[C@]([H])(C#CC1=C([H])N=C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])S1)C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]N(C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C(=O)N(C(=O)N(C1=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N(C(=C(C1=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(SC(=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C(F)(F)F [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C#CC([H])([H])N1C(=O)N(C2=C(N(C(=N2)C(\[H])=C(/[H])C2=C([H])C(N([H])[H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C(C3=C([H])C(=NC([H])=C3N=C12)C(=N[H])N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C(=O)OC1=C([H])C([H])=C2C(OC(=O)C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C3=NC([H])([H])C([H])([H])C([H])([H])N3[H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N1C2=C(C3=C(C([H])=C([H])C([H])=C3[H])C1=O)C([H])([H])C1=C2C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC(=O)[C@@]1([H])N2C3=C(C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])SC([H])=C1[H] [H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1N=NN=C1C([H])([H])[H] [H]N(C1=C(F)N=C(C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])SC([H])([H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=NC(=C1[H])C([H])([H])OC(=O)C([H])([H])[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C([H])C([H])=C(C([H])=C12)C(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NN(C2=C1C(=NC(=N2)C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C(S1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C(C(=O)OC([H])([H])[H])=C(C2=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(C#N)=C2[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 CN(C)CCOC1=CC=C(C=C1)C1=C(C2=C(NC[C@@H]3CCCO3)N=CN=C2N1)C1=CCCCC1 [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(ON=C(OC([H])([H])C([H])([H])[H])C1([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=NN2C(S1)=NC(=C([H])C2=O)C([H])([H])[H])[N+]([O-])=O [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])[C@]1([H])C([H])([H])[C@@]2(OC([H])([H])[H])C([H])=C([H])[C@]11[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]11C4=C(C([H])=C([H])C(OC([H])([H])[H])=C4O[C@@]21[H])C3([H])[H])[N+]([O-])=O [H]N(C1=C2C([H])=C([H])N=C([H])C2=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(\N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])SC1([H])[H])=C(\[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2C([H])=C([H])C(=C([H])N2N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C([H])C2=NC([H])=NC2=C1[H])C1=C([H])C([H])=C(OC(F)(F)Cl)C([H])=C1[H] [H]N=C(N([H])[H])N([H])\N=C1\C2=C([H])C(N([H])S(=O)(=O)C3=C(Cl)N=C4SC([H])=C([H])N34)=C([H])C([H])=C2C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])=C([H])C2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])N([H])C(=O)C1=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C(SC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=C([H])C2=C1C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=NC(N2C([H])([H])[C@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])[C@]3([H])C2([H])[H])=C2N=C(OC2=N1)C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(F)=C(N([H])C(=O)C([H])([H])[H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N(C1=C([H])N(C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C2C([H])=NN(C2=N1)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(F)(F)F [H]C([H])([H])C(=O)O[C@@]([H])(C([H])([H])[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC3=C(N=C([H])N3[H])C(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C(N([H])C(=O)C([H])([H])[N+]2=C(C([H])=C(C([H])=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1Cl)S(=O)(=O)N([H])[H] [H]C1=C([H])N(C([H])=N1)C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N([H])[C@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C(C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C(F)(F)F [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C2=C(C#N)C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(\C([H])=C2/SC(=S)N([H])C2=O)C([H])=C1OC([H])([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])=C2C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=NC([H])=C([H])N1[H] [H]O[C@]([H])(C([H])([H])N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2C([H])=C3OC([H])([H])OC3=C([H])C2=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(OC2=C(F)C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NC(=NC(=N1)N(C1=C(Br)C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)C([H])([H])C1=NN(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C(Br)=C2[H] [H]N(C(=O)C([H])([H])OC1=C([H])C(F)=C(F)C(F)=C1[H])C1=C([H])C(OC2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C(F)=C([H])C([H])=C4[H])C(Cl)=C3[H])=C2[H])=C([H])C([H])=C1[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])[C@@]([H])(OC1=NC([H])=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N1C([H])=C([H])C2=C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C(C(F)=C3[H])C(F)(F)F)C(Cl)=C([H])C([H])=C2C1=O [H]N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=NC(=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=NC([H])=C([H])C(OC2=C([H])C([H])=C3N([H])C(=NC3=C2[H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC(=O)C1=C([H])C2=C(C([H])=C1[H])N1C(=C(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=NC2=C(C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C3=C(C([H])=C(N=C23)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]\C(=C1\OC([H])([H])OC1([H])[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N1C(=O)[C@@](C2=C([H])C([H])=C(OC([H])([H])C([H])=C([H])[H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C(Cl)=C([H])C([H])=C3C([H])([H])[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@]1([H])N=C([H])N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C(OC([H])([H])[H])C2=C(C(OC([H])([H])[H])=C1C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])O2 [H]C([H])=C([H])C([H])([H])N1N=NC(=N1)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@@](N([H])C(=O)[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C2N(C(=O)C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])=NC([H])=N1 [H]C1=NC([H])=C(C2=NC([H])=C(Cl)C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C1\S\C(=N/C([H])([H])C([H])([H])[H])N(C1=O)C([H])([H])C([H])([H])[H])C1=C(N(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC1=NC(=O)N(C([H])=C1[H])[C@]1([H])O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H] [H]N([H])C1=C(\C([H])=N\OC([H])([H])[H])C(=NC([H])=N1)N([H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(=O)N(C1=C([H])C([H])=C2N(C(=O)[C@@]([H])(OC2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(N=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(I)C([H])=C(C([H])=C1I)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(Br)C2=C1OC1=C([H])C([H])=C([H])C([H])=C1C2=O [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(O[H])C([H])([H])[H])C([H])([H])SSC1([H])[H])[C@@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N([C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2SC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])[C@@]1([H])OC(OC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3OC([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C2=C1[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C2([H])[H])[C@]1(O[H])C([H])([H])C([H])([H])[C@@]([H])(O[H])C3([H])[H])C(=O)N([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C3=C(N=C(C(=N3)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] FC1=CC(=CC=C1)C(C1=NC2=CC=CC=C2N1)=C1C(=O)NC2=C1C=CC=C2 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C([H])=C(C([H])([H])[H])C([H])([H])N([H])C1=NC([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(C#N)=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H] [H]N([H])S(=O)(=O)OC([H])([H])C1([H])OC2=C([H])C([H])=C([H])C([H])=C2O1 [H]O[C@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])N(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H] [H]\C(=C(\[H])[C@@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(N=C(N=C3N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])N3C4=C(N=C3[C@]([H])(OC([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C4[H])N2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(=NC(=N1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(=C([H])C(=C2O1)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])\C([H])([H])C([H])([H])[H])C1=C2C([H])=C([H])C(=O)C([H])=C2OC2=C([H])C(O[H])=C([H])C([H])=C12 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C(C3=C(O2)C([H])=C(C(Cl)=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O\N=C(\C(=O)N([H])C([H])([H])C([H])([H])S[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(I)=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C(=O)N([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C(OC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1C2=C(C([H])=C1C1=C([H])C3=C(N([H])C1=O)C([H])=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(C2=C([H])C([H])=C([H])O2)=C(N([H])[H])C(F)=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C(N=C(N=C1[H])C([H])([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[S@](=O)C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C(=N\O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C1=C([H])N=C(N=C1SC([H])([H])C([H])([H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]N([H])C(=O)C1=C([H])C(N([H])C(=O)N([H])C(C2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C12)C1=C([H])C(Cl)=C([H])C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])SC1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]1([H])C2=C(OC([H])([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])=C(Br)C([H])=C2[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1N([H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(=C1[H])C(C(=O)N([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])S1)[S@](=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@](SC2=NC3=C([H])C(Cl)=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Br)S1)[C@@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=NC(=C([H])C(=C1[H])C([H])([H])[H])C(F)(F)C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C(=O)N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C2=NC(N([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C1=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])[H])C(=O)C(=O)N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])SC1=C(C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C1S\C(=C(\[H])C2=C([H])C([H])=C(O2)C2=C([H])C(Cl)=C(C([H])=C2[H])S(=O)(=O)N([H])[H])C(=O)N1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C(=O)OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC(=O)C(\F)=C(\C1=C([H])C2=C(O1)C(=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] CC1=C(CCOCCCO[N+]([O-])=O)C=C(N1C1=CC(F)=CC=C1)C1=CC=C(C=C1)S(C)(=O)=O [H]N(C(=O)N1C([H])([H])C([H])([H])C(F)(C2=NC(=NO2)C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C2=C(C([H])=C(Br)C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NN([H])C(=C3[H])C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(N(C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=C2C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C2=NC(=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]O\N=C(/N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NOC(=C1[H])C1=C2N(C([H])=C(C2=C([H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]C1=C([H])C(=NN1C1=C2C(=NC(=C1[H])C([H])([H])[H])N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])C([H])([H])S1(=O)=O [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])N1C([H])=C(C([H])=C(Br)C1=O)C(=O)OC([H])([H])[H] COC(COC1=CC=CC=C1)CN(C)C1CCN(CC1)C1=NC=NC2=C1C(=CS2)C1=CC=CC=C1 [H]\C(=N\OC([H])([H])[H])C1=C(N=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)SC3(C2=O)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C1=C2N=C([H])C([H])=C(C2=C(OC2=C(Br)C([H])=C([H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=NC2=C(S1)C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C(OC([H])([H])[H])C(=C([H])C(OC([H])([H])[H])=C1Br)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C(Cl)=C2C(=O)N(C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C(Br)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]N([H])C1=C([H])C(=C(N([H])C(=O)N([H])C2=C(C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3[H])C3=C(N=C([H])C([H])=C3[H])N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C([H])C2=C1C([H])=C([H])C1=C2C([H])([H])[C@]2(C1=C(C(=O)C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NN(C(=O)C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C1Cl)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]S\C(=N\C([H])([H])C1=C([H])N=C(C([H])=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(SC(F)(F)F)=C1[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C([H])=C(C(=NC2=NC([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]1([H])[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C(F)=C(N([H])[H])C(Br)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C(SC3=C([H])C([H])=C4OC(=C([H])C4=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C2C([H])=NN(C2=N1)C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C(F)=C1[H])C1=C([H])C([H])=C(C([H])=C1F)[C@@]1([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C2OC(=NC2=C([H])C(O[H])=C1[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]\C(=C1/C(=O)N2C(=C([H])C([H])([H])S(=O)(=O)[C@]12[H])C([O-])=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N(C1=NC(N([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[H])=C(C([H])=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N(C(=O)C1=C(Cl)C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC2=C(N=C(N2[C@@]2([H])C([H])([H])C3([H])N(C([H])([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Br)C(=NO1)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(C(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])N=C12)C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(Br)=C(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=NN=C(S1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C2=C1C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=NN=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])OC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@]1([H])N(C([H])([H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)[C@]2([H])N(N=C([H])C2([H])[H])C(=O)C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C2=C(F)C([H])=C(F)C(F)=C2[H])C([H])=C1[H] [H]O[C@@](C([H])([H])N([H])C(=O)C1=C(N([H])[H])N(N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H])C(F)(F)F [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] CC1=CC(OCCCN2C(=CC3=CC=CC=C23)C(O)=O)=CC(C)=C1Cl [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C(Br)=C([H])C([H])=C2O1 [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])[C@@](O[H])(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(N([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[C@@]2([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1F [H]N(C(=O)OC([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C(=O)N1C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]1([H])O[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C2N=NN(C2=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(=NO1)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=NC([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H] [H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C2N([H])C(=C([H])C2=C1[H])C1=C([H])C(=C([H])C(Br)=C1[O-])[C@]([H])(C([O-])=O)C([H])([H])C([O-])=O [H]C1=C2N(C3=C(C2=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N(C([H])([H])C3([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C(=O)S[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=NN=C2SC([H])([H])C(=NN12)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=N1)C(C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C(=O)N1C([H])([H])SC([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(OC(=O)N([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=O)N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)[C@@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)S1)C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]N(C(=O)C([H])([H])C1=C(N=C(N1C([H])([H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1F [H]C([H])=C([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C(=C(Cl)C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])([H])[H] [H]N=C(N([H])[H])N([H])C(=O)[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])S2(=O)=O)=C1[H] [H]N(C1(C(=O)N2C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C2N=C(C([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N([H])S(=O)(=O)C1=C([H])C(=C([H])S1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(O2)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C([H])C4=C([H])C5=[N+](C([H])=C34)C([H])([H])C([H])([H])C3=C([H])C4=C(OC([H])([H])O4)C([H])=C53)C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C(C([H])=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]1(C(=C([H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]2(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])[C@@]3([H])C([H])=C([H])C([H])([H])OC([H])([H])[C@]3([C@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]21[H])C([H])([H])[H])C([H])([H])C(=C([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])[S@@](=O)OC([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1(C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[C@@]([H])(N([H])OC([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C([H])OC(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C#CC2=NC(Cl)=NC([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2C(N=C(OC([H])([H])C([H])([H])[H])N=C2C2=C([H])C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])=C([H])C(OC([H])([H])C3([H])C([H])([H])C3([H])[H])=C2[H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC1=C([H])C(=O)C2=C(N1[H])C(C#N)=C(SC([H])([H])C(=O)N([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C([H])([H])[H])S2 [H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H] [H]O[C@@]1([H])C(=O)O[C@]([H])(C([H])([H])N([H])C(=O)OC([H])([H])C(Cl)(Cl)Cl)C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CCCOC(=O)C1=C2C3=CC=C(N4CCSCC4)C4=CC=CC(C2=NC1=O)=C34 [H]N1C(=O)C2=C(C1=O)C1=C(N3C4=C1C([H])=C([H])C([H])=C4C([H])([H])C([H])([H])C3([H])[H])C1=C2C2=C(N1[H])C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2C([H])=NN(C2=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=C([H])C(Cl)=C(C#N)C([H])=C2[H])[C@]([H])(C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=N1)(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C2=C(N=C(S2)C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] CC(C)N1C=NC2=C(NC3=CC=NC=C3)N=C(Cl)N=C12 [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])[H])C(=N/C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H])\N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N([H])C(=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(=O)N(C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1C(=O)O[H] [H]OC(=O)C1=C([H])N(N=C1[H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]SC(=N[H])C1=C([H])C2=C(S1)C([H])=NC([H])=C2SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=NC(=NO2)C2=C([H])C([H])=C(O[H])C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C(Br)C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])[H])[C@]1([H])N=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C#N)[C@@]([H])(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[N+]([O-])=O)C(C(=O)OC([H])([H])C([H])([H])[H])=C(O1)C([H])([H])[H] [H]N1C(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])C2=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])[C@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C(N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3F)C([H])([H])C1([H])[H])C1(C#N)C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C([H])N(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=NC(N([H])[H])=C2N=C([H])N(C2=N1)[C@]1([H])C([H])([H])[C@]([H])(N2N=C([H])C(=C2[H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]1([H])O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@@]([H])(C1=NC([H])=C([H])S1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N([H])C1=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C2C([H])=N1 [H]N1[C@]([H])(C(=O)N(C([H])([H])C#N)C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C(=O)N([H])C1=NN([H])C(=S)S1 [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C1=C(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NOC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[C@@]3([H])OC4=C(C([H])=C([H])C([H])=C4[H])N(C([H])([H])[H])C3([H])[H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]C1=C(ON=C1C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(N=C1N([H])[H])C([H])([H])N1C(=C([H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=N\N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])\C#N CC1=CC=C(C=C1)C(=O)CC(NC1=CC=C(C=C1)N(O)=O)C1=CC(F)=CC=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C(=N1)N([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C([H])C([H])=C1\C([H])=C1/SC(=O)N(C1=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC2=C(C(Cl)=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])[H])=N1 [H]OC([H])([H])[C@]([H])(N([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])=C([H])C([H])=C12)C(=O)N([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C([H])C(=N1)C([H])([H])SC1=C([H])C([H])=C([H])C(=C1[H])C(=O)O[H] [H]N1C2=NC(=C([H])C([H])=C2OC([H])([H])C1=O)N1C([H])([H])[C@]([H])(OC([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C(C(=O)C([H])([H])[C@]1([H])C(=O)O[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])=C(C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C([H])C([H])=C(C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C([H])C(=N1)C1=C(C(N2C3=C(C([H])=C([H])C(=C3[H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])=C2C(F)=C([H])C([H])=C([H])C2=N1)C([H])([H])[H] [H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])C([H])=NC(SC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=N1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H])[C@]1([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N2C(=N1)C(=NC([H])=C2C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])O[C@@]([H])(OC1([H])[H])C([H])([H])N([H])C(=O)[C@]([H])(N1C(=O)N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H] NS(=O)(=O)C1=CC(=CC=C1)N1N=C(CO)C=C1C1=CC2=CC=CC=C2C=C1 [H]N(C1=C([H])C2=C(N([H])C([H])=C2C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C(Cl)N=C2SC([H])=C([H])N12 [H]OC1=C([H])C([H])=C2C(OC(=O)C([H])=C2C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]ON([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N(C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])O[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])OC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=NC(=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])N([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=N2)C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(ON=C1C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1C(=O)N([H])N=C2C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])[C@@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])[C@]([H])(C2=C(F)C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(O[C@]2([H])C([H])([H])C3([H])N([C@@]([H])(C([H])([H])C3([H])[H])C2([H])[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C(C(OC2=C([H])C([H])=C([H])N=C2C(F)(F)F)=N1)C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C([H])N(N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)[C@@](N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]OC1=C([H])C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])N(C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] COC1=NC(=NC(OC)=C1F)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=C(F)C=C(F)C=C1 [H]N(C(=O)[C@]1(N([H])N=C(C1([H])[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C(F)(F)F [H]N(C(=O)C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[C@]1([H])N([H])C(=O)N([H])C1=O [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] CN(C)CC(=O)NC(C1=CC=C(Cl)C=C1)C1=NC2=CC=C(C=C2C(=O)N1)C1=CNN=C1 [H]N(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C(SC([H])([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=N\OC(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]4([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])OC1=C([H])C([H])=C2N=C(SC2=C1[H])S(=O)(=O)N([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N([H])C(=O)OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(N3C(=O)N([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C(=NC2=C1C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C(=O)\C(=C(/[H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H] CC1=C(Cl)C=CC=C1C(=O)N1CCC[C@@H](C1)C1=NC(=NO1)C1=C(Cl)C=CC=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)[C@]1([H])N(C(=O)C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1(C2=NC(=C(N2[H])C2=C([H])C([H])=NC(N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1Cl)N1C([H])([H])C([H])([H])N2C([H])([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C(\C#N)=C1\SC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2N=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(N4C(=O)C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])SC2=C1[H] [H]N(C(=O)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C([H])[N+](=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])O[C@@]([H])(OC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C(=NN1C1=C([H])C(F)=C([H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1(C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] COC1=C(C=CC(NC(=O)C=C)=C1)S(=O)(=O)N1CCN(CC1)C(=O)OC(C)(C)C [H]N1C2=C([H])C([H])=NN2[C@]([H])(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C([H])([H])[H] [H]N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C2C(=C1[H])N(C([H])=C2[C@@]([H])(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=NN=C([H])N2C([H])([H])[H])C([H])=C1C(=O)N([H])C1=NC([H])=NS1 [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C1=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C2N=C([H])N(C2=N1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N(C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=NC([H])=C(O2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S1 FC1=CC=CC=C1C(=O)N1CCN(CC1)C1=NN=C(C=C1)C(=O)NCCC1CC1 [H]C1=C([H])C(Br)=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C(Cl)=C2C(=O)O1 [H]ON(C([H])=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] COC1=CC2=C(CCC(=O)N2CCCN2CCC(CC2)NC(=O)CC2=CC=CC=C2)C=C1 [H]N1C(=O)C2=C([H])C([H])=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C2C1=O [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(SC([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=C2C(=NC1=O)C([H])=C([H])C(=C2Br)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C(Br)=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H] COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)C(=NO)N3CCCC3)C2=O)C=C1 [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C([H])=C3[H])C(=O)N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C1C2=C([H])C(=O)C([H])=C([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]3(C(=O)C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(F)=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] FC1=CC=C(C=C1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC(Cl)=C1 [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(N([H])C([H])([H])C([H])([H])[H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C#N)C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=C1[H])C(F)(F)F [H]OC(=O)[C@]([H])(N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])S[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OP(=O)(O[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]N1C(=NC2=C1C([H])=C(Cl)C(Cl)=C2[H])N(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(C#N)=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C(Br)=C(S1)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C(=O)O[H])C([H])=C1[H] [H]C1=NN2N=C(C(=C2C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C(F)=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(N1[H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=C([H])C(=C(C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H])S1 [H]N1C(=O)C2=C3C4=C(C([H])=C([H])C([H])=C4[H])N4C3=C3N(C5=C(C([H])=C([H])C([H])=C5[H])C3=C2C1([H])[H])[C@@]1(O[C@@]4([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])([H])[H])[C@]1([H])OC([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(OC1=C([H])C([H])=C(C([H])=O)C([H])=C1[H])=C2[H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] CC1=CC=CC=C1N\C(=N/N=C\C1=CC=C2C=CC3=CC=C(\C=N/N=C(\NC4=CC=CC=C4C)C4=NC=CC=C4)N=C3C2=N1)C1=CC=CC=N1 [H]N([H])C1=NC(C2=C([H])N([H])C3=C(Br)C([H])=C([H])C([H])=C23)=C(C([H])=N1)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N1C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])C([H])([H])OC1=NOC(=C1[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] CC#CCN1C(=O)C2=C(N=C1N1CCC[C@@H](N)C1)C(Br)=CN2 [H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=NC3=C(C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C3[H])C(N([H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] COC1=CC(=CC=C1OCCN1CCCC1)N1CC2=CC=C(SC3=CC(Cl)=C(F)C=C3)N=C2C1=O [H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(Br)C(Br)=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=C(C(=O)C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C(=C2N1[H])[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C2C1=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N1C(=NN=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C(=O)N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=NC(=NO1)C1=NC([H])=C([H])C([H])=C1[H] [H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H] NC(=O)C1=C(NC(=C1)C1=CC=NC(N)=N1)C1=CC=CS1 [H]OC1=C(C#N)C2=C(C(SC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)=N1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] CCCN1N=CN=C1C1=C(C)NC2=CC=NN2[C@@H]1C1=CC=C(Cl)C(Cl)=C1 [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])[H])N1C([H])=C(C2=C1N=C([H])N=C2N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])N2C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C(=O)O[C@@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C2=NOC3=C2C([H])=C([H])C(OC([H])([H])[H])=C3[H])C2=C([H])C([H])=C(C([H])=C12)C(F)(F)F)C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]OC([H])([H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(=N1)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1OC(=C2[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])N(C2=C(C([H])=C3N=C(N=NC3=C2[H])N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=N[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(N=C(C(=O)N2[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1Cl [H]OC(=O)C([H])([H])N([H])C(=O)C(=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C([H])([H])S[H] [H]N(C(=O)C1=C(N=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C(C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC([H])([H])C1(C2=C([H])C(OC([H])([H])C3=C([H])C4=C(C([H])=C3[H])N(C(=O)C([H])=C4[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])SSC([H])([H])[C@@]([H])(N(C1=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]O[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N(C1=NC(=NC(=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])N1C([H])=NC2=C1C([H])=NC([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=NC3=C(O[H])C([H])=C([H])C([H])=C3N=C12 [H]N([H])C(=O)C1(N([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C2=C([H])N=C(C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C(=N2)C2=C([H])C([H])=NC(Cl)=C2[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C1=NN=C(O1)C([H])([H])[H])C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C(C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N([H])S(=O)(=O)N1C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]OC(=O)[C@@]([H])(N([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)SC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2N=C([H])C(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3C([H])([H])[H])C2=C([H])C([H])=C1[H] [H]C1=NC([H])=C(C(=C1[H])C1=NC(=C2N=NC3=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C3N12)C([H])([H])[H])C([H])([H])[H] [H]O[P@@](=O)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(N([H])[H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])S1 [H]N(C1=NC(=C(S1)C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C([H])=C([H])C([H])([H])OC(=O)N1C([H])([H])SC([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])SC([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N([C@]1([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3C([H])([H])[C@]21C(=O)OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)[C@]1([H])[C@@]([H])([N@@]2C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]