[H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C(=S)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23 [H]C1=C(C2=C(S1)N=C(OC2=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])N(OC(=O)C([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@](N([H])C(=O)C([H])([H])[H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C([H])=C(N1C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])N(C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] ClC1=CC=CC(NCN2N=C(OC2=S)C2=NC3=CC=CC=C3C=C2)=C1 [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C(F)(F)F [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]ON(C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C1(F)C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)S(=O)(=O)C(F)(F)F [H]OC1=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])S2)=C([H])C([H])=C1[H] [H]N(C1=C([H])C(=NN1[H])C([H])([H])[H])C1=NN(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NC([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])OC1([H])[H] CCCCN(C(=O)C1=CC=CC(Cl)=C1)C1=NN=C(S1)C1=CC=CN=C1 [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] CN1N=CC2=C1N=CC(=C2)C#CC1=C(C)C=CC(=C1)C(=O)NC1=CC(=C(CN2CCN(C)CC2)C=C1)C(F)(F)F [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])N=C(SC([H])([H])[H])N=N1 [H]N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N1C2=C(C([H])=C1C1=C([H])C(=C3N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C3=C1Cl)C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(=C([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NN(N=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC([H])=C([H])N12)C1=C(Cl)C([H])=C(Cl)C(=C1[H])[N+]([O-])=O [H]OC1=C([H])C(=C2C(=O)N(C([H])([H])OP(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])S(=O)(=O)C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C(N([H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(N([H])C(=O)C1=NN([H])C(=C1[H])C([H])([H])[H])C(\[H])=C1/C(=O)N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])SC1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])[C@]4(OC(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C5([H])[H])C([H])([H])[C@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C4C(C([H])=C(C#N)C([H])=C4C4=C([H])OC([H])=C4[H])=C3[H])=N2)C([H])([H])[C@]2([H])OC([H])([H])[C@@]([H])(O2)C1([H])[H] [H]N(C(=S)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1OC([H])([H])[H] [H]N([H])C1=NC(=C([H])C(=N1)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]1([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C1N=C([H])N=C2N([H])[H] [H]N(C1=N\C(=C(\[H])C2=C([H])N([H])C3=NC([H])=C([H])C([H])=C23)C(=O)N1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C1=NC([H])=NC2=C1C([H])=C([H])N2[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]S\C(=N/C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H] [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C(=O)C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C2=C(C([H])=NC3=C([H])C([H])=NN23)C([H])([H])C1=O [H]OC(=O)C1=C(SC([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1F CC1=CC=C(C=C1)S(=O)(=O)N(CC1=CC=CC=C1)CC1=CC=C(C=C1)N(CCCl)CCCl [H]O[C@@]1(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=NN=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=NOC(=C1[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NN=C(N1C([H])([H])[H])C1=C(OC([H])([H])[H])C2=C([H])C(Cl)=C([H])C([H])=C2C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N1C([H])=C(N=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N(C1=NC([H])=C([H])C2=C(N([H])C3=C(C([H])=C([H])C([H])=N3)C3=NC([H])=NC([H])=C3[H])C(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=C(C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] F[P-](F)(F)(F)(F)F.CN(C)C1=CC=C2C([Se]C3=CC(C=CC3=C2C2=CC=C(S2)C(=S)N2CCCCC2)=[N+](C)C)=C1 [H]N1C([H])([H])C([H])(OC2=C(Cl)C([H])=C([H])C(=C2[H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])=C2C3=C([H])C([H])=C([H])C([H])=C3C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]\C(=C(\[H])C1=C2C(=C([H])C([H])=C1[H])[C@@](OC2([H])[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])C([H])([H])OC([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SC([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C(F)C([H])=C23)C([H])([H])[H])C1=O [H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C2N(C1=O)C1=C(N([H])C2=O)C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC(=NC3=C2N=NN3C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C(=O)N([H])C(=C([H])C1=O)C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C4C([H])=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2(C#N)C3=C(SC([H])([H])C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)O[H] [H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H] CN1C(=O)N(C2CCN(CC2)C(C)=O)C2=C1C=NC1=CC=C(N=C21)C1=CC=C(C)N=C1 [H]OC(=O)C1=C([H])C2=C(C([H])([H])[C@@]3([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])N1C(=S)S\C(=C(\[H])C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1=O [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C12)C([H])([H])C([H])([H])Br [H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)N1OC(=O)C(=C1C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@@]([H])(O[C@]2([H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@](OC([H])([H])[H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@]4([H])N(\C(O[C@@]34[H])=N\C([H])([H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])[H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1(OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C(C(=C1[H])C1=NC([H])=C(N=C1[H])C(=O)N(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H])C(=O)O[H] [H]O[C@]1([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])[C@]5(C([H])([H])[C@@]35C(=O)C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N=C(SC([H])([H])[C@@]41C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1N([H])C([H])=O)[C@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C([H])N(C2=NC([H])=N1)[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H] [H]N(C(=O)[C@]([H])(N1C(=O)C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)C([H])([H])SC2=C1C([H])=NC([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@](C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(C#C[C@@]1(OC([H])([H])[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H] [H]N1N=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])N=C12)C(=O)C1=C(F)C([H])=C(OC([H])([H])[H])C([H])=C1F [H]C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1(C2=C([H])C([H])=C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])=C2[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]ON([H])C(=O)[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C3C4=C([H])C([H])=C5C(=O)N(C(=O)C6=C5C4=C(C([H])=C6[H])C4=C3C2=C(C([H])=C4[H])C1=O)C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])O[H] [H]C(=O)C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C(F)=C1F [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)S\C(=C(\[H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O [H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=NOC(=N3)C3([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N([H])C1=NC2=C(C([H])=C(Cl)C([H])=C2O1)C(=O)N([H])[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]C1=NN2C([H])=C(C([H])=NC2=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C3N=C([H])SC3=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C1=C(C([H])([H])[H])C([H])([H])C([H])([H])N(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C1=O [H]N([H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N1C(=O)N(C(=O)C1(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(SC(F)(F)F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C#CC2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N([H])[C@@]1([H])C(=O)[C@@]2([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C4=C([H])OC([H])=C4[H])C([H])([H])[C@]23C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])=N3)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1[C@]1([H])N(C2=O)C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C#N [H]C1=C([H])C(SC2=C(C(=O)C(=O)C3=C4C(=C([H])C([H])=C23)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1F [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN([H])N=N1 [H]N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=NN=C2C([H])=C([H])C(SC3=C([H])C([H])=C(F)C([H])=C3F)=C([H])N12 [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=NC([H])=C2C([H])=C1[H] [H]N(C(=O)C1=NC([H])=NC(=C1[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C2N([H])N=C([H])C2=C1[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=N2)C(=O)N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C([H])C(=C2F)C(F)(F)F)C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])C1(C(=O)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])=C([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=NC(=C([H])N=C2N([H])[H])C2=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]\C(C1=C([H])C(Cl)=C([H])C([H])=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C3([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])N=[N+]=[N-])[C@@]1([H])O[H])N1N=C(I)C2=C(N=C([H])N=C12)N([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])[C@]12[H] [H]OC1=C(N=C(C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])S[H])C(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2SC3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C(=O)O[H] [H]C1=C([H])C(\N=C2/SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C1=C(N([H])C(\C([H])=C2/C(=O)N([H])C3=C2C([H])=C(F)C([H])=C3[H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C(=O)C2=C(Cl)C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[C@]2([H])N([H])C(=O)N([H])[C@]12[H] [H]N1C2=C(C([H])=C([H])C([H])=N2)C(=C1C([H])([H])[H])[C@]1([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])(C([H])([H])N([H])C([H])=O)C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)[S@](=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N([H])C1=NC2=C(S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C21)C([H])([H])[H] OC(=O)C1=CC2=C(OC(=C2\C=C/C2=CC(F)=CC(F)=C2)C2=CC=CC=C2)C=C1O [H]N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=NC(=C([H])S1)C1=C([H])C2=C(N([H])C3=C4C(=C5C(=O)N([H])C(=O)C5=C23)C([H])([H])C([H])([H])C4([H])[H])C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O\N=C(/[H])C1=C(N([H])C([H])([H])C([H])([H])[H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1N=C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)N2C([H])([H])[C@]([H])(O[C@@]([H])(C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]2([H])C1([H])[H] [H]C1=C(Cl)C(=C([H])C(Cl)=C1SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C2N=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C(SC([H])=C3[H])C2=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H] [H][C@@]12C[C@H](OC(=O)C3=CC=CC=C3C#N)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C2C3=C(C([H])=C(S3)C(=O)N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])[H])C([H])([H])C([H])([H])OC2=C1[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C2[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C(N=C2OC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=NN=C([H])S1 [H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C([H])C(OC(F)(F)F)=C([H])C([H])=C3[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C(N=C(Cl)N=C23)N([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C3([H])[H])[C@@]1(O[H])C([H])([H])[H])C([H])([H])Cl [H]N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1F)C1=C(C3=C(C([H])=C([H])C([H])=C3[H])C(=O)N1[H])C2([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(Br)S1)C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C([H])([H])N(C([H])([H])[H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC1=C([H])C([H])=C([H])C2=C1[C@@]13C([H])([H])C(=O)C([H])([H])C([H])([H])[C@@]1(OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C3([H])[H])C2([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])[H])=C3[H])C([H])([H])[C@]12[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]N(C1=C([H])C(=O)OC2=C([H])C([H])=C(Cl)C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] FC1=CC(NC(=O)NC2=CC=CN=C2OC2=CC=CC(=C2)C(F)(F)F)=CC=C1 [H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C([H])C(I)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(C(=O)O[H])[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(N2[H])C2=C(C3=C(C([H])=C(O[H])C([H])=C3[H])N2O[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]2([H])O[H])C2=C1C(=O)N(N([H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C2=O [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C([H])=C([H])C(O[H])=C2[H] [H]N1C(=NC2=C([H])C([H])=C(C([H])=C12)S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C2=NC([H])=C(N2C([H])=C1[H])C1=C([H])C(O[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C(S1)C(=O)N([H])[H] COC[C@H](C)OC1=CC(\C=C\C2=CC=CC=C2OC)=CC(=C1)C(=O)NC1=NN(C)C=C1 [H]O[C@](C#CC1=C([H])N2N=C(N=C2C(=N1)N([H])[H])C1=C([H])C([H])=C([H])O1)(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C([H])=C(O1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)C(C2=C1C(F)=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(F)=C1[H] [H]N([H])[C@@]1(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])N(C2=C3C(Cl)=C([H])N([H])C3=NC([H])=N2)C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C([H])C([H])=C(N=C2C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=C(C([H])=N2)C2=C([H])C([H])=C3OC([H])([H])C([H])([H])OC3=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C(OC1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=C2[H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])C([H])=C2C(=N1)N=C(N(C2=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C(C([H])=NC2=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])=C(C2=C(N=C([H])N=C12)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])\N([H])[N+]([O-])=O [H]N(C(=O)[C@]([H])(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2N(C(=O)C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N1C2=C3C([H])=C(OC4=C(C#N)C([H])=C([H])C(=C4[H])C([H])([H])N4C([H])=NC([H])=C4C([H])([H])C(=O)N([H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C3=C([H])C([H])=C2[H] [H]O[C@@]([H])(C([H])([H])C([H])([H])SC1=NC([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(OC(=O)N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])C2([H])[H])C([H])([H])N([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] CC(C)(C)C(=O)NCCC1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C(Br)=C(Br)C([H])=C1Br [H]OC(=O)C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C3(C([H])([H])N(C4=C([H])C([H])=NC([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2N([H])C(=O)SC2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CC1=CC(CNC(=O)C2=C(N)C3=C(C)C(Cl)=C(C)N=C3S2)=CC=N1 [H]N(C(=O)[C@@]([H])(N1C(=O)[C@@]([H])(N2C(=O)OC([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])S(=O)(=O)N([H])[C@@]1([H])O[C@]([H])(C([H])([H])OC(=O)C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N([H])[H])C2=C(S1)C1=C([H])N(N=C1C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] CN1C=C(C=N1)C1=CC2=C(C=CC3=C(C=C(CC(N)=O)C=C3)C2=O)N=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C(=[N+]([O-])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1N=C(C([H])=C1C([H])([H])[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])[C@]1([H])O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C1=C(N([H])C2=C([H])N=C([H])N=C2[H])C([H])=C([H])C(=N1)C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])N=C1[H])C(=O)N([H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C(=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])=C1[H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C#N)C2=C(S1)C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=C2C(=NC(=N1)C([H])([H])[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=NC([H])=C([H])C([H])=N1 [H]OC(=O)C1=C([H])C([H])=C(C#CC2=C([H])C3=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])=C3C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])[H])[N+]([O-])=O [H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C#N)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C(C(=C(C([H])=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H] [H]OC1=C(O[H])C(=O)[C@]([H])(O1)C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C(S1)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C([H])N2C1=C(C(=O)C(=O)N([H])[H])C(=C2C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C1(C2=NN=C3N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C(F)=C([H])C(F)=C3[H])C([H])([H])[H])N(C3=C([H])C([H])=C([H])N=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C(=O)C2=C1C([H])=C([H])C(OC(F)(F)F)=C2[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([C@@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])N2C([H])=C([H])N=C2C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1 [H]O[C@@]([H])(C1=C(C2=C([H])C([H])=C([H])C([H])=C2O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N([H])C1=C(C2=NC3=C(C([H])=C(C([H])=C3N2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C#N)C([H])([H])C2([H])[H])C([H])([H])[H])C(=O)N([H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C2C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(C(=O)[C@@](N([H])C(=O)OC([H])([H])C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])[H])[C@@]1([H])C(=O)N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NN(\C(S1)=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=NOC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=N1)[C@@]([H])(N1C([H])([H])C([H])([H])N3C(=O)C([H])([H])C([H])([H])[C@@]3([H])C1([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C2C(=O)C(=C(OC2=C1[H])SC([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]([H])([C@@]1([H])C([H])([H])[C@]1([H])C(=O)[C@@]([H])(OC(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])[C@]1([H])OC(=O)C([H])=C([H])C1([H])[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C(=NN([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])=C1[H])N([H])[H] [H]C1=C([H])C(C2=C([H])C([H])=C(Br)C([H])=C2[H])=C(C([H])=N1)[C@]1([H])OC([H])([H])C(=O)N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])[C@@]4(C(=O)N([H])C([H])([H])C4([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]\C(C1=C([H])C([H])=C([H])O1)=C1\C(=O)\C(=C(/[H])C2=C([H])C([H])=C([H])O2)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC(SC2=NN=C([H])N2[H])=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])S1 [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=NC(=NO1)C1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1N([H])[C@]([H])(C(=O)N(C2([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]OC([H])([H])C([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=NC([H])=C(C([H])=C2[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=NC(=C1[H])C1=NN([H])N=N1 [H]N(C(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC1=C([H])C(C2=C([H])C(Cl)=C([H])C([H])=C2[H])=C2C([H])=C(C([H])=C([H])C2=N1)[C@](N([H])[H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]N1C(=O)S\C(=C(/[H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C1=O [H]OC([H])([H])[C@@]1([H])C([H])([H])[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(I)=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C1=C2C([H])=C([H])C(=C1[H])C([H])([H])[C@@](O[H])(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])\C(=C([H])/C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(N=C(N2C([H])([H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]N([H])C1=NC(=C(N=N1)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])\C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])[H])=C1C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[N+]([O-])=O [H]O[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C(C([H])=C(OC([H])([H])[H])C(OS(=O)(=O)N([H])[H])=C4[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=NC(=C(C2=NC(=NN12)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=NC3([N+]([O-])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]C(=O)OC1=C([H])C([H])=C([H])C2=C1C1=C3C(=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C2([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NN(N=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(=C([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(\C([H])=C2\C(=O)C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])SC([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(\N=C(/[H])C2=C([H])OC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N([H])C([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C(Cl)C([H])=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1([H])[H])C1=C3C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N1[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C1=NC(=C(N1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC([H])([H])C2=C([H])N(N=N2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC1=C(\N=N\C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C(=C(\N=N\C3=C(O[H])C4=C(N([H])[H])C(=C([H])C(=C4C([H])=C3[H])S([O-])(=O)=O)S([O-])(=O)=O)C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C2=C(C([H])=C(C(N([H])[H])=C12)S([O-])(=O)=O)S([O-])(=O)=O [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])C2=C(N=C3N2C([H])=C([H])C([H])=C3Cl)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N1C2=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C1([H])[H])C([H])=C([H])C(C#N)=C2[H] [H]ON([H])C(=O)[C@@]1([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(OC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(Br)=C(OC2=C([H])C([H])=C(O[H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(Br)=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])SC([H])([H])[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]1([H])OC1([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=NC(C2=C([H])N=C(N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C(F)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=C(I)C2=C1N=C([H])N=C2N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C1\C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C(Cl)C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])=NC([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=NC([H])=C2C2([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]OC1=C(C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@]3([H])[C@@]4([H])C([H])([H])C([H])=C(N5N=C([H])C([H])=N5)[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H] CCSC(=N)NC1=CC=C(C=C1)N(O)=O [H]C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])=N1 [H]C1=NC([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(SC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])=NN=C1C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[C@@]2([H])N(C(=O)C([H])([H])C3=C([H])C4=C(N=C(O4)N([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])[C@@]([H])(F)C2([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])F)C([H])([H])C([H])([H])C([H])([H])[C@]1(C([H])=C(C2=C([H])C(F)=C([H])C([H])=C2F)C([H])([H])N1C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(N([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C2=NC([H])=NC(Cl)=C2[H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])OC(=N2)C([H])([H])OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(Cl)SC(Cl)=C1[H])C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H] CC1=C(N(N=C1C(=O)NCCNCCN)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(Cl)C=C1 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=NN([H])N=N1 [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])C([H])([H])O2)C1=C([H])C(F)=C(F)C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([O-])=O [H]C#CC1=C2C(N([H])C([H])=C2C(=O)C2=C([H])C([H])=C(C(F)=C2[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C2C(=NC3=NC(SC([H])([H])[H])=NN13)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(F)=C(Cl)C([H])=C2[C@](C1=O)(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C(=O)O2)C([H])=C1[H] [H]O[C@](C1=C([H])N(N=N1)C([H])([H])C1=C([H])C([H])=C2C(SC([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])(C([H])([H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN([H])C(=S)S1 CN1C(\C=C\C2=CC=C(C=C2)C(C)=O)=CC2=C1C(=O)N(C)C(=O)N2C [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(N=C(S3)C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] NC(=O)C1=C[Se]C(=N1)C1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C(=O)C2=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C([H])C(=C([H])N=C1N([H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C(N=C2C([H])=C([H])C(Cl)=C([H])N12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NN(C2=C1C([H])=C(C([H])=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N(C(=C1C#N)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C(=O)N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H] [H]N1N(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(C1=O)C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C1(C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=NC(=NN12)C([H])([H])[H] [H]C1=C(N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C([H])C(=C1[H])[N+]([O-])=O [H]N1C([H])=C([H])C2=C1C(Br)=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(N=N2)C1=NC(C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(C([H])=C1C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)SC3=C([H])C([H])=C(Cl)C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C(S1)[C@](N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H] CC(C)=CC1=C(O)C(C=C(C)C)=C2OC(=CC(=O)C2=C1O)C1=CC=CC=C1 [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=N\C#N)\N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C2C([H])=C(N([H])C([H])([H])C3=C([H])N(N=N3)C3=C([H])C([H])=NC([H])=C3[H])C([H])=C(Cl)C2=NC([H])=C1C#N [H]N([H])C1=N[C@](C(=O)N1C([H])([H])[H])(C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H]