[H]N([H])C1=C(N([H])C2=C([H])C([H])=C(C(=O)C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C(Cl)=C2[H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C2=C1N([H])C(=O)C([H])=C2[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])N(C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])N([H])C(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(OC([H])([H])[C@](N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H])=C1[H] [H]OC1=C([H])C(OC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=C([H])C([H])=C1C(=O)C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C2C(=NC3=C([H])C(F)=C(F)C([H])=C13)C1=C([H])C3=C(C(=O)N1C2([H])[H])C([H])([H])OC(=O)[C@]3(O[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)C3=O)C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)O[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=NC2=C(N=C(N=C2N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(N([H])C(=O)C([H])([H])N2N=C(C3=C([H])C([H])=C([H])C([H])=C3N(C2=O)C([H])([H])C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])SC([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(C3=C(S2)C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C3([H])[H])C(=O)O1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C(N2C([H])=C([H])C3=C2C([H])=C([H])C([H])=N3)=C(C1=O)C1=C([H])N(C2=C([H])C(Br)=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[N+]([O-])=O)[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C(S2)C2=NC([H])=C(S2)C2=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C2[H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N=C(O1)N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1)C([H])([H])[H] [H]OC(=O)C(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2O[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]N([H])C1=C(N=C(O1)C12C([H])([H])C3([H])C([H])([H])C([H])(C1([H])[H])C([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C3([H])[H])C2([H])[H])C#N [H]N1C([H])([H])C2=C(C([H])=NC(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C(=O)[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=N1)N([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H] [H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(OC(=N2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=N1 [H]C1=C(C(N2C3=C(C(=C2C([H])([H])[H])C([H])([H])[H])C(=NC(=N3)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])F)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SN=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O [H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C([H])C(=C2[H])C(F)(F)F [H]OC(=O)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C([H])C([H])=C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C12)C([H])([H])[H] [H]C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=NC3=C2C([H])=C([H])N=C3[H])C([H])([H])[H])C2=C(C#N)C([H])=C([H])C([H])=C2N1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N=C1N([H])[C@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C21C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[C@@]1([H])OC1([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C(=NN1[H])C1=C([H])C(=C(O[H])C([H])=C1O[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=NC2=C(OC(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])C([H])([H])OC3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C2([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C(Cl)C([H])=C(Cl)C(=C1[H])C([O-])=O CN(C(=O)C1=CC2=C(S1)C1=CC=CC=C1OCC2)C1=CC=C(F)C=C1F [H]N([C@@]([H])(C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] CCB(CC)OC(=O)[C@@H](N)CCCCNC(=S)NCC1=CC=C(C=C1)S(N)(=O)=O [H]OC(=O)C1=C([H])C([H])=C(N([H])C2=NC(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(C([H])=N2)[C@]2([H])N=NN=C2[H])C([H])=C1[H] [H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N=C([H])C(=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]\C(=C1/C(=O)N2C(C([O-])=O)=C3[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[C@]3([H])OC([H])([H])[H])[C@]12[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] CC[C@H](C)NC(=O)C1=CN2N=CN=C(NC3=C(C)C=CC(=C3)C(=O)NC3CC3)C2=C1C [H]N([H])C(=[N+]([H])[H])C1=C([H])C2=C(N([H])C(=N2)C2=C([O-])C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C(\[H])=C(/[H])C([H])([H])C([H])([H])S[H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])S[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C2=NC([H])=NC([H])=C2C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=C(F)C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C([H])=C(C([H])=C(Br)C2=N1)C([H])([H])[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N(N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NC2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C1=O [H]C1=C([H])N(C(=C1[H])[C@]1([H])OC2=C(N=NC(SC([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]ON(C([H])=O)[C@]([H])(C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])S1)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1)S(=O)(=O)C1=C([H])C([H])=C(Br)C(Cl)=C1[H] [H]O[C@@]1([H])C([H])([H])[C@@]([H])(O[C@]1([H])C([H])([H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=C([H])C(=O)N([H])C2=O)[C@]([H])(O[H])[C@]1([H])O[H])N1C([H])=NC2=C1N([H])C(=NC2=O)N([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[P@](=O)(OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(C2=NC3=C(N([H])N=C3C([H])([H])[H])C([H])=C2[H])=C(N=C1[H])C1=C([H])OC([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C(OC(=O)C([H])([H])[H])=C2[H])N=C(SC([H])([H])C([H])([H])[H])N=N1 [H]N([H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C(=O)N(OC([H])([H])[H])C([H])([H])C1=C([H])C(C(=O)N([H])OC([H])([H])C([H])([H])O[H])=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C1F [H]OC1=NC2=C([H])C([H])=C(C([H])=C2N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)N1C([H])([H])[H] C1CCC(CC1)C1=CN=C2C=NC3=C(C=CN3)N12 [H]OC(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C3=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1S(=O)(=O)N([H])[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C(F)=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C3=O)=C1[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C3=C([H])C([H])=C([H])C(OC([H])(F)F)=C3[H])C2=N1)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])N=C(N=C1[H])N([H])C1=NN=C(S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])SC1=C(C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)C([H])=C2O1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C(C1=[N+](C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H])=C1C([H])=C(OC(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(O[C@]([H])(C([H])([H])[S@+]1[O-])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C12)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])[N+]([O-])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]N(C1=NN(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C12 [H]C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2N=C1N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]C1=NC(F)=C([H])C2=C1C1(OC2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(N=C2[H])C(=N/OC([H])([H])C([H])([H])[H])\C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])([H])C1([H])[H] [H]N(C1=[N+](C2=C([H])C([H])=C([H])C([H])=C2C(=N1)N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C5[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H] [H]N(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=S)N1N([H])C2=C(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]1([H])C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N2N=NC(=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N3N=NC(=C3[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]3(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H] [H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(OS(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F)C([H])=C2[H] [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C([H])([H])N([H])C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C([H])C(OC3=C([H])C([H])=NC4=C3C([H])([H])C([H])([H])C(=O)N4[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] CC1(C)OB(OC1(C)C)C1=CC=C(OS(N)(=O)=O)C=C1 [H]N([H])C(=O)N([H])C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])C([H])=C([H])[H] [H]N([H])C1=C(N=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C([H])C([H])=C2N=C(SC2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1OC([H])([H])[H])C(=O)N([C@]1([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3C([H])([H])[C@]21C(=O)OC([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])[C@@]1([H])SC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])[H] [H]OC(C1=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2S1)C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N1[C@@]2([H])C(=C([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N([H])C1=C(C([H])=C([H])C([H])=N1)C(=O)C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C1([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C([H])C([H])=NN3C(N([H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C1=C(C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2O1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] CC1=NC2=CC=CC(N3CCN(CCC4=C5OCC6=C(N=CN6C5=CC=C4)C(=O)NC4CC4)CC3)=C2C=C1 [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1Cl)C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]O\C(OC([H])([H])[H])=C1/C(=NC(=C(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H])N([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]O[C@@](C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H] [H]N(C(=O)C(=C(/[H])C([H])([H])[H])\C([H])([H])[H])[C@]1([H])C([H])=C2C([H])([H])C([H])([H])[C@@]3([H])C4=C([H])C([H])([H])[C@]([H])([C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C1[H] [H]OC1=C2N=C3C([H])=C([H])C(OC([H])([H])[H])=C([H])C3=C2C([H])=C([H])N1C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])N=C([H])C(=C1[H])C1=C([H])N=C2N([H])C([H])=C(C2=C1[H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2[H])C([H])=C1[H])C1=C(C#N)C([H])=NC([H])=C1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])C([H])=C(N=C12)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]SC([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(OC(=O)C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C(F)(F)F)[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1C([H])([H])[H])C([H])([H])C([H])([H])N([H])C2=O)C1=C([H])C(=C([H])C([H])=C1OC(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NC1=C(O2)C([H])=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C(=O)C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(O1)C([H])([H])[H])C1=NC([H])=C([H])S1 [H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(SC2=NC([H])=C([H])N2C([H])([H])[H])C(Cl)=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(\C([H])=C(/[H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12 [H]OC1=C([H])C(F)=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C([H])C(C([H])=C([H])[H])=C2O1 [H]N([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=NC(N([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C2C(SC3=C([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])N([H])C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(SC2=NN=C([H])N2C([H])([H])[H])=C([H])C([H])=C1SC1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C(OC3=C([H])C(=NC([H])=N3)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C([H])C([H])=C2S1 [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] COCCCC1=NC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CN=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)=C1 [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=S)C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])N1C(=O)N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])OC([H])([H])[H] [H]N([H])C1=NC2(N([H])C3=C([H])C([H])=C([H])C(F)=C13)C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC([H])([H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O[H] [H]N(\N=C1/C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C1=C(N=C([H])N1C([H])([H])C([H])([H])C([H])([H])OC1=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C(C([H])=NC2=C1[H])C1=C([H])C(=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(I)=C([H])C([H])=C1SC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] CN1CCN(CC2=C(C=C(NC(=O)C3=CC(C#CC4=CC5=C(NN=C5)C=C4)=C(C)C=C3)C=C2)C(F)(F)F)CC1 [H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] [H]N(C(=S)N([H])[C@]1([H])C2=C(C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CCNC1=NC(C(N)=O)=C2CN(CCC2=N1)C(=O)CCC1=CC=C(CC(F)(F)F)C=C1 [H]OC(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N(C1=C(Cl)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C(SC([H])=C1[H])C(=O)C([H])([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C#N)C([H])([H])C2=C([H])SC([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]