[H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(C(=O)C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C(C3=C([H])C4=C([H])N=C([H])C([H])=C4N3[H])=C2O[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C3=C(C([H])=C2C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])=C3C1=C([H])C([H])=C(S1)C([H])([H])[H]
[H]N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])S1(=O)=O
[H]N(C(=O)C([H])([H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])[C@]2([H])C3=C(C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N1C(=O)C2=C(C3=C(N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C2C2=C([H])C([H])=C([H])C([H])=C2N3C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1F)[C@]1(C([H])([H])C([H])([H])[C@]([H])(C([H])([H])S(=O)(=O)C(F)(F)F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]([H])(C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])C([H])([H])C(=O)C1=NC(=NO1)C([H])([H])[H]
[H]N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C2=C(S1)S(=O)(=O)N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C(=C2[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])O\C([H])=C(\C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(Cl)SC(=C1[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C3([H])[H])C3(OC([H])([H])C([H])([H])O3)C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(F)=C([H])C2=C1[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N(C(=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1
[H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C2C([H])=NC([H])=C([H])C2=C1[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@]1(OC(=O)\C(=C(\[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C([H])([H])OC(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])N([H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C2N(C(=O)C(=O)C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C1[H]
[H]N(C1=NC2=C([H])C(=C(C([H])=C2N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N([H])C2([H])[H]
[H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C1=NN(C(OC([H])([H])C([H])([H])C2=NC3=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N3[H])=C1[H])C([H])([H])C(F)(F)F
Cc1cnc(NCC2CCOCC2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1
[H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C3=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])C1=C2N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]ON([H])C(=O)C([H])([H])[C@]1(N([H])[H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C3=C4C([H])=C([H])C([H])=C([H])C4=NC(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])S1
[H]OC(=O)C1=NN([H])C2=C1C([H])([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C2([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(F)C([H])=C2N2C1=NN=C2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])O[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=NN=C1C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])C([H])([H])OC([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C2=NC3=C(C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])([H])[H])N2C([H])([H])[H])=C1C([H])([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C(OC3=C([H])C(Cl)=C(F)C([H])=C3[H])=C12)C([H])([H])[H])S(=O)(=O)C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Br)=C(OC2=C([H])C(=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H]
[H]N(C(=O)C([H])(OC(=O)C1=C([H])C(=C(C([H])=C1[H])[S+]([O-])(=O)C([H])([H])[H])[N+]([O-])=O)C([H])([H])[H])C1([H])C2([H])C([H])([H])C3([H])C([H])([H])C([H])(C2([H])[H])C([H])([H])C1([H])C3([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1C1=NC(N([H])C(=O)C2=C([H])C([H])=C([H])S2)=C(C#N)C(=C1[H])C1=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C2N([H])C(=O)SC2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2N=C(OC2=NC([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=NC(N([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C3([H])[H])=C([H])N=C2C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC(C)(C)OC(=O)N1[C@H]2CC[C@H]1CC(C2)OC1=NC=NC(NC2=CC=C(C=C2)S(C)(=O)=O)=C1[N+]([O-])=O
[H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C#CC1=C([H])C([H])=C(C#CC([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N(C([H])([H])C2=C(N=C3N2C(=O)C(=C([H])N3C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C(=O)OC([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]1(SC(=NC1=O)N([H])[C@]([H])(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])[C@@]1(N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@@]2([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@@]12[H]
[H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(F)=C([H])C([H])=C3OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])OC2=C(OC1([H])[H])C([H])=C(C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=C([H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(O[H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C(N([H])C([H])=N1)C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(F)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=NC(Cl)=C(C(OC([H])([H])[H])=C2C([H])([H])[H])C([H])([H])[H])C(Cl)=N1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC3=C(C#N)C([H])=NN3C(=N2)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H]
[H]N([H])C1=NC(N([H])[H])=C(C([H])=N1)C([H])([H])N1C([H])([H])C2=C(C3=C(N2[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])([H])O[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)O[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])=C([H])C2=C1C([H])([H])[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]2(\N=C(/[H])\C(\[H])=C(/[H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])\C1=C(/[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H]
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]N=C(N([H])[H])N([H])C1=NC([H])=C(Cl)C([H])=C1C#CC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1O[H])C([H])([H])C([H])([H])C2=C(C#N)C#N
[H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2=C3C(=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])[C@]13[H]
[H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=NN=C1C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=O)O[C@@](C1=O)(C1=C([H])C([H])=C(N([H])C1=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])C([H])([H])F)C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(=NS1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)S(=O)(=O)N([H])[H]
[H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C([H])=C(C([H])=C3[H])C(=O)N(C(=O)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=NC([H])=C2S1
[H]N(C1=NC(C2=C([H])N=C3N2C([H])=C(F)C([H])=C3F)=C(Cl)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@@]1([H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C([H])N([H])C2=NC([H])=C1[H]
[H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2F)N2C([H])=C([H])C([H])=C([H])C2=O)C1([H])[H]
[H]OC1=C(O[H])[C@@]2([H])C3=C([H])C([H])=C([H])C4=C3[C@]([H])(N(C([H])([H])[H])C([H])([H])C4([H])[H])C([H])([H])[C@@]2([H])C([H])=C1[H]
[H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NC(=NC(=C1[H])C1=C([H])N=C(N=C1[H])N([H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H]
[H]ON([H])C(=O)C1=C([H])N=C2N(N=C(C2=C1N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N1C(=O)C2=C(C1=O)C1=C(C([H])=C([H])C3=C1N(C([H])=C3[H])C([H])([H])[H])C1=C2C2=C(N1[H])C([H])=C(C#N)C([H])=C2[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=NC(=C(Cl)S2)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C#N)C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H]
[H]C1=C(Br)C([H])=C(Br)C(=C1[H])N1N=NC2=C1N=C(N=C2N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C(=C1[H])C(=O)N(C([H])([H])OC(=O)C1=C(Br)C([H])=C([H])C([H])=C1Br)S2(=O)=O
[H]OC(=O)C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H]
[H]OC1(C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])C2=C(C([H])=C(Br)C([H])=C2[H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C2SC(=C3[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)=C1[H]
[H]N1C([H])([H])C2=C(N=C(N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(N([H])C3=C(C([H])=C(C4=C([H])N=C([H])O4)C(OC([H])([H])[H])=C3[H])C(=O)N2C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N=[N+]=[N-])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC1=C([H])C([H])=C(C(O[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C3=NC4=C(N3[H])C(=O)N(N=C4C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
CN(C)CCOC1=CC=C(C=C1)C1=C(C2=C(NC[C@@H]3CC[C@H]3O)N=CN=C2N1)C1=CC=CC=C1
[H]N(N1N([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H]
[H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C(Br)C([H])=C2[H])C([H])([H])N([C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H])S(=O)(=O)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2F)C([H])=C1[H]
[H]N=C(N([H])C1=C([H])C([H])=C2N=C(SC2=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1
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[H]C([H])=C([H])C([H])([H])N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H]
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2O[H]
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[H]N1C2=C(SC3=C2C(OC([H])([H])[H])=C([H])C([H])=C3[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C([H])C(=NN1C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2N(C2=C(C([H])=C([H])C([H])=N2)C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C(SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C(=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=C(C([H])([H])[H])C2([H])[H])C([H])([H])[H]
[H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N1C(=O)C(C2=C([H])C(=NO2)C([H])([H])[H])=C(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C2=C([H])C(Cl)=C([H])C([H])=C12
[H]C1=NC(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C2=NN=C3N2C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C3([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]C([H])([H])N1C2=C(N3C(=N2)N(C([H])([H])C3([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])[H]
[H]N([H])C1=NC(SC([H])([H])C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=NN1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])[C@](OC([H])(C([H])([H])[H])C([H])([H])[H])(OC1=O)C([H])([H])[H]
[H]C([H])([H])N1C2=C(N3C(=N2)N(C([H])([H])C([H])([H])C3([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H]
[H]N1C(=O)N(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(C#N)N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])[C@]2([H])C3=C4C(=C([H])C(=O)C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]3(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12