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[H]C([H])=C([H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C1=C(N=C2N1C1=C(N=C([H])C([H])=C1[H])N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=C([H])C(Cl)=C([H])C2=C1N([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@](C#N)(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F
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[H]C([H])=C([H])C1=C2C3=C(S1)C([H])=C([H])C(Cl)=C3C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H]
[H]N([H])[C@]([H])(C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NN(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O\C(OC([H])([H])C([H])([H])[H])=C1\C(=NC(C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]1([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])S1
[H]N([H])C(=N/C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H])\N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C1=NC(=C(Cl)C([H])=N1)C1=C2N([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=NC([H])=C(F)S1
[H]N1C([H])([H])C([H])([H])O[C@]([H])(C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C(I)=C([H])C([H])=C1[H]
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[H]OC1=C([H])C([H])=C(N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])[N+](C1=C([H])C([H])=C([H])C(OC(=O)C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])=NC([H])=N1
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[H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(O[C@]2([H])C([H])([H])N(C3=NC([H])=C([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]\C(=C1/C2=C([H])C([H])=C(Br)C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
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[H]N(C1=NC([H])=C(SC2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])S1)C1=NC([H])=C(Br)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])\N=C(/[H])C1=C([H])OC2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]OC(=O)C([H])([H])C([H])([H])N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(O[H])(C(F)(F)F)C(F)(F)F
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[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC(OC([H])([H])C([H])([H])[H])=NC(OC([H])([H])C([H])([H])[H])=N2)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(\C([H])=N\N([H])C(\S[H])=N\C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C(=C1O[H])C1=C(O[H])C3=C(C(=O)C4=C(C([H])=C(O[H])C(=C4O[H])C([H])([H])[H])C3=O)C(OC([H])([H])[H])=C1C([H])([H])C2([H])[H]
[H]C1=C(C([H])=C(Br)C(=C1[H])N1C(=O)N(C2=C1N=C(N=C2N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(OC([H])([H])[H])=C2N(C(=NC2=C1Br)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
CC(C)C1=C(CC2=CC=C(CCCC(=O)NC(C)(C)C(=O)NCCO)C=C2)C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN1
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=NC2=C([H])C(=C(OC3=C([H])C(=C(O[H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C2C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])[C@@]1([H])N2C(=O)C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C21)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C4=C(C([H])=C3[H])N(N=C4[H])C([H])([H])C3=C([H])N=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])C1=C([H])SC(C(=O)N([H])C2=C(C([H])=C(Cl)C([H])=C2OC([H])([H])[H])C(=O)N([H])C2=NC([H])=C(Cl)C([H])=C2[H])=C1Cl)C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=C1[H])C1=NSC(=N1)C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]N([H])C(=O)C1=C([H])N(C2=C([H])C([H])=C3C(=C2[H])C([H])([H])C([H])([H])C3([H])[H])C2=C(C([H])=NC(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1=O
[H]OC(=O)C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C(Br)=C(OC2=C([H])C([H])=C(O[H])C(=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H]
[H]C1=C([H])N2C(=C1[H])C([H])=C(SC1=C2C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C([H])([H])N([H])C1=NC([H])=C(S1)C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
[H]OC1=C2N([H])C(=NC2=NC(=N1)N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C(Cl)=C([H])C([H])=C1N([H])C1=C(N([H])C2=C(Br)C([H])=C([H])C([H])=C2[H])C(=O)C1=O)S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=NC3=C([H])C([H])=C([H])C([H])=C3C(=O)N1C([H])([H])C2([H])[H]
[H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C([H])O1
[H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N([H])C(=O)C([H])([H])[C@@]([H])(C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H]
[H]N([H])C1=NC(=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C13)C([H])([H])OC2([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1(C(=O)N([H])C2=C([H])C(Cl)=C(Cl)C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C2=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C([H])=C([H])C(=C2N(C1=O)C([H])([H])C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN([H])N=N1
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C(=O)N([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C1([H])[H]
[H]N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C2C(=O)N(C(=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])[C@@]1([H])C(=O)N(C2=C1C([H])=C(Br)C([H])=C2[H])C([H])([H])[H]
[H]OC1=NN=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(C([H])=C4C(=O)OC([H])([H])C4=C3C3=C([H])C([H])=C([H])N=C3[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(NCCN(C)C)N=C3)C2=O)C=C1
[H]C1=C([H])C(=C([H])C(=C1[H])N1N=C(C#N)C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F
[H]N(C(=O)OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC3=C([H])C([H])=C([H])C([H])=C3OC2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C(S1)C1=NOC([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C1=C(Br)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]C([H])=C([H])C([H])([H])C1=C(OC([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C([H])C(=C2O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]C1=C2N(C(=C(C2=C([H])C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
[H]OC(=O)C1=C([H])N=C2C([H])=C([H])N(C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2S1
[H]C1=C([H])C(=C([H])S1)C1=C(C2=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Br)=C([H])C([H])=C12
[H]O[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])[C@]2([H])C(=O)OC([H])([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1O2)C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])OC1=C(F)C(=C([H])C([H])=C1[H])C1=C(N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1F)C(F)(F)F)C([H])([H])[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N(C(=O)N1C([H])([H])C(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])=C(C#N)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(Br)=C(C#N)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N@@+]1(C([H])([H])[H])C([H])([H])C([H])=C([H])[C@@]([H])(C([H])([H])C(=O)[C@]2([H])SC3=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C([H])C([H])=C1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H]
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[H]N([H])[C@]1([H])C(=O)N([H])C2=C(C([H])=C([H])C(N([H])C3=NC(N([H])C4=C(F)C([H])=C([H])C([H])=C4C(=O)N([H])C([H])([H])[H])=C(Cl)C([H])=N3)=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C([H])=C(O1)C1=NN(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=N1
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[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N(C1=NN=C(O1)C1=C([H])C([H])=NC([H])=C1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)Cl)C([H])=C1[H]
[H]C1=NC([H])=C(N1C([H])([H])[H])[C@](OC([H])([H])[H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C2=C1[H])C([H])([H])[H]
[H]N([H])C1=C2C(=NC3=C1C([H])=C([H])C(Cl)=C3[H])C([H])([H])[C@@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N([H])[H]
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[H]N(C(=O)C1=C([H])N([H])N=C1[H])C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C(N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2S1
[H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(\N=C1/C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])=NC(=C2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1N([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)N([H])N([H])C(=O)C1=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1N(C(=C(C1=O)C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])SC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(\C(=C1/C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CS(=O)(=O)C1=CC=C(C=C1)C1=CC2=NC=C(C#N)C(N3C=CN=C3)=C2C=C1
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[H]N(C1=NC([H])=C(C([H])=C1[H])C(F)(F)F)C1=C2N=C([H])C(=C([H])C2=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C(F)(F)F
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
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[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1F
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[H]N(C([H])([H])C1=C([H])N=C([H])C(Cl)=C1C([H])([H])OC1=C2N=C(C([H])=C(C3=C([H])C([H])=NN3C([H])([H])[H])C2=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
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[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])N([C@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])N(N=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H]
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[H][C@@]1(CCCCN1)[C@H](C(N)=O)C1=CC=CC=C1
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[H]N1C(=O)C2=C(N=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1O2)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC(=O)C1=C([H])C2=C(C([H])=C1[H])N1C(=C(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)OC([H])([H])[H]
[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N3C4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4C([H])([H])C([H])([H])[C@@]3([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)\N=C1\SC(=NN1C([H])([H])[H])S(=O)(=O)N([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])C([H])([H])[H])C2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])N=C(SC([H])([H])[H])N=N1
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@@]21C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC1=C(C([H])=C([H])C(C#N)=C1[H])C([H])([H])O[C@]([H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=NN=C(O1)C1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H]
CC(C)N1C=CN=C1C1=C(C)NC2=CC(=NN2[C@@H]1C1=CC=C(Cl)C(Cl)=C1)C(F)(F)F
COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(C(Cl)=C1C(C)C)C(F)(F)F
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC(N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C3=C([H])C([H])=C([H])S3)=C(I)C([H])=N2)=C1[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=NC(OC3([H])C([H])([H])N(C4=C([H])C([H])=C5C([H])=C([H])C([H])=C([H])C5=N4)C3([H])[H])=C(C([H])=N2)C2=C([H])C(=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC(OC([H])([H])[H])=C(C([H])=N1)C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC2=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C(=C([H])C3=C([H])C(O[H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]SC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=NN(C1=O)[C@@]([H])(C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1C(F)(F)F
[H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C2C3=NN=C(C([H])=C3C(=O)C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3[H])N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C1=C(C(=O)N([H])C1=O)C1=NC([H])=C(C([H])=C1Cl)C(F)(F)F
[H]C1=C([H])C(C2=NN(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC([H])=C(C#CC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]
[H]N1C2=C(C3=C1C([H])=C(C([H])=C3[H])C(F)(F)F)C1=C(N([H])C(=O)C([H])([H])C1([H])[H])C([H])=C2[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(N1[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NN(C2=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C1=C(OC2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC2=NC([H])=C(Br)C([H])=N2)=NC(=N1)C1=NC([H])=C([H])C([H])=N1)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C([O-])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])N=C3N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C(=C([H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C#N)C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])=C(C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(Cl)N(N=C2C(F)(F)F)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])[C@](C1=C([H])N=C([H])N1C([H])([H])[H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N3C([H])=C([H])N=C3C([H])=C(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C2=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C(=O)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])N([H])[H]
[H]OC1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=C(N([H])C2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C([H])C(=N1)C([H])([H])SC1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H])C1=C3C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)C([H])([H])C(=O)N1C([H])([H])C(=O)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(Br)C([H])=C(\C([H])=C2/C(=O)N([H])C3=C([H])C([H])=C4SC(=NC4=C23)N([H])[H])C([H])=C1Br
[H]C1=C([H])N(C(=C1[H])C(=O)OC([H])([H])C1=C([H])SC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(ON1[H])=C1C([H])=C([H])C(=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F
[H]OC1=C2\C(=C(\[H])N3C([H])([H])C([H])([H])C(=O)C([H])([H])C3([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]O[P@@](=O)(C([H])([H])[H])[C@]([H])(C(=O)N([H])C(\[H])=C(/[H])C1=C([H])C([H])=C(F)C(F)=C1[H])C1=C([H])N(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C2=O)C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=NN(C(=C1[H])C(=O)N1C2=C(C([H])=C([H])C(=C2[H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2ON=C(N([H])[H])C2=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])=C([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]O[C@@]1(N(\C(SC1([H])[H])=N\C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@](C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])(C1=C([H])C([H])=C2N(N=C([H])C2=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(F)(F)F
[H]N(\C(=N/C#N)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F
[H]N(C(=O)[C@@]1([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]N(C(=O)N([H])C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)N2C([H])([H])C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(\[H])[C@@]([H])(C#CC2=C([H])C([H])=C([H])C([H])=N2)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]N(C1=C(C(=O)N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])OC([H])([H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C(N1[H])C([H])([H])[H]
[H]N(C1=NC2=C(S1)C(=NC([H])=N2)N([H])C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N=C([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(F)C(OC([H])([H])[H])=C1[H]
[H]C1=C(Cl)C(C(=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C(Cl)C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C2=C1[C@]([H])(N([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C3C([H])=C([H])N([H])C3=NC(=N2)N([H])C2=C(OC([H])([H])[H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])S1
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])N(C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCCC1
[H]N1C2=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C(=NC([H])=C2[H])C([H])([H])[H])C([H])([H])C1=O)C(F)(F)F
[H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])[C@]2(C3=C(F)C([H])=C([H])C(F)=C3OC([H])([H])[C@@]12[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C1=NC([H])=C([H])S1
[H]N(C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1)[C@@]([H])(C(=O)N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N(\N=C(/C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=NC(=C([H])S1)C1=C(F)C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])N=C(OC([H])([H])C([H])([H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])N=C(OC([H])([H])[H])N=C1[H]
[H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C2=C(N(N=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C(N=C2N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C#CC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])N(C(I)=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=C(C2=C(O1)C([H])=C([H])C(=C2[H])S(=O)(=O)N1C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(OC2=NC([H])=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1N=C([H])C2=C1C([H])([H])C([H])([H])C1=C2N(N=C1C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1=C(N([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(\[H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C12
[H]C1=C(SN=C1C([H])([H])[H])N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C3=C2[H])C([H])([H])[H])C1=O
[H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(O[H])C(Br)=C([H])C([H])=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])C2=NN([H])N=N2)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])(P([O-])([O-])=O)P([O-])([O-])=O
[H]C1=C([H])C2=C(S1)C([H])([H])[C@]([H])(O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C#N
Fc1ccc(cc1)-c1n[nH]cc1-c1ccnc(NC2CCCCC2)c1
[H]C1=NC(=C([H])N1C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])C1=C([H])N(N=N1)C([H])([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])C([H])([H])[H]
[H]N([H])N([H])[C@@]([H])(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([O-])=O)[N+]([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]O[C@]1(C2=C([H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H]
[H]C1=NN(C2=C1C(=NC(SC([H])([H])C([H])([H])[H])=N2)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(F)(F)F
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])N=C([H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C2([H])[H])[C@]1([H])C(=O)OC([H])([H])[H]
[H]OC1=C(F)C([H])=C(C([H])=C1F)N(C([H])([H])C1=C(F)C([H])=C(Br)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])N=C(C([H])=N1)N1C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@]2(N(C(=O)N(C2=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C1([H])[H]
[H]C1=C(Cl)N(C2=NC(=C(N12)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H]
CC(=O)NCC1=C(C=CC=C1)C1=CC(C)=C(C=C1)C(CN)CC1=CC=C(OCCOC2=C(Cl)C=C(C)C=C2Cl)C=C1
[H]C#CC([H])([H])N([H])[C@]1([H])C2=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=NN=C(N2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]([H])(N1C([H])=C([H])C([H])=C(C(=O)N([H])C([H])([H])C#CC2=C([H])C([H])=C3N=C([H])C([H])=C(OC([H])([H])[C@]4([H])C([H])([H])OC([H])([H])C4([H])[H])C3=C2[H])C1=O)C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]O[C@@](C([H])([H])N1C([H])=C([H])C(=O)C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])C(C1=C(C([H])=C([H])C(F)=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]N(C1=NC(=NC2=C([H])C(Cl)=C(Br)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1N=NN=C1C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H]
[H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2N(C(=N3)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)=C([H])C([H])=C1[H]
COC1=NC(=NC(=C1F)C(C)(F)F)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=CC=C(F)C=C1F
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N(C([H])([H])C2=C([H])C3=C(N=C(N=C3O[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C(F)=C1[H])C(=O)O[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1=C(C([H])=NC2=C([H])C(Cl)=C(C([H])=C12)C1=C([H])N(N=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]\C(C1=C([H])C([H])=C(OC([H])(F)F)C([H])=C1[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C#N
[H]C1=C(C([H])=C2C([H])=C(C(=NC2=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(N([H])C(=O)C2=C([H])N=C(S2)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=NN1C([H])([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(O[H])C(C3=C([H])OC([H])=C3[H])=C2C([H])=C1[H]
[H]N1C([H])([H])[C@]2([H])N(C3=NC(=C([H])C([H])=C3C2([H])[H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C3([H])[H])C3(OC([H])([H])C([H])([H])O3)C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]\C(SC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])=C(\[H])/C(/[H])=C(/[H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NC(=NO1)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H]
[H]C#CC([H])([H])OC([H])([H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NC(=C(S1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C(=O)C2=C(N=C(S2)N2C3=C(OC([H])([H])C2([H])[H])C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(OC([H])([H])[H])N=N2)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
[H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C(Cl)=C([H])N=C3[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]N1N=C(N=C1C1=C([H])C([H])=NC(=C1[H])C([H])([H])[H])C1=C([H])N=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H]
[H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C(=O)C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C(OC([H])([H])[H])C([H])=C(C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC2=C(O1)C([H])=C([H])C(Cl)=C2[H]
[H]OC1=NC2=C([H])C(C#CC([H])([H])N3C([H])([H])C([H])([H])C([H])(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1[H]
[H]N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C1=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])N21)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(OC([H])([H])[H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]C1([H])N(C([S-])=S)[C@]([H])(C([O-])=O)C([H])([H])C1([H])[H]
[H]N1C2=C(C([H])=C([H])C3=C([H])N=C(C([H])=C23)C2=C([H])N=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C2[H])C2=C1C([H])([H])N([H])C2=O
[H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC1=C([H])C2=C([H])C([H])=C(C([H])=C2C(C#CC([H])([H])[H])=C1[H])C1=C([H])C(F)=C(O[H])C([H])=C1[H]
OC[C@@H](NC(=O)c1cc(c[nH]1)-c1ncnc(Nc2ccccc2)n1)c1cccc(Cl)c1
[H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=NC3=C(C([H])=C([H])C([H])=C3[H])C([H])=C1[H])=C2[H]
[H]ON([H])C(=O)C1=C([H])N=C2N(N=C(C2=C1N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3OC(=C([H])C(=O)C3=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N=C(C#N)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=NC(C#N)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C(C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(F)C([H])([H])C2([H])[H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
C[C@H]1CCC[C@H](C)N1S(=O)(=O)C1=CC=C(C=C1)N1CCCC1=O
[H]C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C(SC2([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O\N=C(\C(=O)N([H])C([H])([H])C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(Br)=C1[H]
[H]N1C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O1)SC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])([C@@]([H])(OC([H])([H])C([H])=C([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C([H])=C([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C2N([H])C(=NC2=NC(=N1)N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])O1
[H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])C([H])([H])C3=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=NC(OC([H])([H])[H])=N1)N([H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(Cl)=C1Cl)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H]
COC1=C(OCCC(=O)NC2=CC=CC=C2)C2=C[N]3=C(C=C2C=C1)C1=CC2=C(OCO2)C=C1CC3
[H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C2N=C(C([H])=C([H])C2=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C([H])C(SC([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(S1)[N+]([O-])=O
[H]N(C1=C([H])C([H])=C(C([H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])[N+]([O-])=O)S(=O)(=O)C([H])([H])[H]
C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C(=O)OC1CCCC1
[H]C1=C(F)C(F)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N2N=C(N=C12)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])S1)C1=C(N(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\[C@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C1=NC([H])=C([H])N=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])[C@]1([H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C3C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C2[H])[C@@]1([H])C(=O)O[H]
[H]O[C@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]N1C(=O)C2=NN(C([H])=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2SC(=C([H])C2=N1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])[C@@]1([H])C2=NC([H])=C(N2C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(F)=C2F)C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN([C@@]([H])(C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H])S(=O)(=O)C([H])([H])[H]
Cc1cnc(NCC(F)(F)F)nc1-c1cc(C(=O)N[C@H](CO)c2cccc(Cl)c2)n(C)c1
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C2C([H])=C([H])C([H])=C([H])C2=N1
[H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C(=O)N1C([H])([H])[C@]([H])(O[H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])(C(=O)O[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C(=O)O[H])C(=O)O[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C(=O)O[H])C(=O)O[H]
[H]N(C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C([H])=N2)C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C([H])C(Br)=C(OC2=C([H])C([H])=C(O[H])C(=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(Br)=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])N1C(=C2C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C12)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1F)C1(C2=NN=C3N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=C([H])N=C([H])C(=N1)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@@H]1CS(=O)(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
[H]O\C(=C(/[H])C1=C([H])C2=C(S1)C(=NC([H])=N2)N([H])C1=C([H])C2=C(N([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])=C(C2=C([H])C(Cl)=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C2C([H])=C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C(=O)C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@@]3([H])C([H])([H])N(C([H])([H])[C@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C(Cl)=C([H])N12)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N([H])C(=O)C2=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1N2C([H])([H])[H]
[H]N(C1=C(C(=O)C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C(=C2N1[H])[N+]([O-])=O)C1=C([H])C([H])=C(C([H])=C1Cl)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C(C2=O)=C34)C([H])([H])C1([H])[H]
[H]N1C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2C2=C1C(=O)N([H])C([H])([H])C2([H])[H]
[H]ON1\C(SC([H])=C1C([H])([H])C(=O)O[H])=N/C(=O)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(C2=NC(=NO2)C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N1C(=O)N([H])C(=O)C(OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N(C(=O)C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]N([H])C1=NC([H])=NC2=NN(C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C(N([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C2C(OC3=C(C([H])=C([H])C(=C3[H])C([H])([H])[H])S2(=O)=O)=C1[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N1C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])[C@@]([H])(C(=O)OC([H])([H])[H])C1([H])[H]
[H]C1=C(C(=NN1C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)O[C@@]1([H])C([H])([H])C2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C(=NN=C1Cl)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])SC1=NN=C(O1)C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])N(C([H])=C2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(Cl)C1=O)C([H])([H])[H]
[H]OC([H])([H])[C@]1([H])C([H])([H])N2C3=C(C4=C2C(=C([H])C([H])=C4[H])C1([H])[H])C1=C(C(=O)N([H])C1=O)C1=C3C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])C1=C(Cl)C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)=C([H])C([H])=C2C([H])([H])[H])C([H])=N1
[H]N(C1=C([H])C([H])=C(N=N1)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])N2C2=NC3=C(S2)C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C1=NC([H])=C(Br)N=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C1=NN=C(O1)C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C1=NN=C(O1)C([H])([H])[H]
[H]OC1=C(OC([H])=C([H])C1=S)C(=S)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C1=NC2=C(N1[H])C([H])=C([H])C(F)=C2[H]
[H]OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=N[H])C([H])([H])F)=C1[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC([H])=C2C([H])=C([H])N(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])SC2=C([H])C(O[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=C1[H]
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C([H])C([H])=C([H])C([H])=C3Cl)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C(F)C(F)=C([H])C([H])=C2[H])=NC2=NC([H])=C(N=C12)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C(=C([H])C([H])=C1C1=C(C([H])=C(C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C(O1)C1=C([H])C2=C(N=C([H])S2)C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C(C(=O)N([H])C3=NC([H])=C([H])C([H])=C3[H])\C(OC2=C1[H])=N\C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])I
[H]O[C@]([H])(C(\[H])=C(/[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C([H])C(=C1[H])C([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])[C@@]1([H])C([H])([H])OC(O[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N1C(SC([H])([H])C([H])([H])C([H])([H])[H])=C2C3=C(C([H])=C([H])C([H])=C13)[C@@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C2([H])[H]
[H]C([H])=C([H])C([H])([H])OC(=O)C1=C(C2=C(N1[H])C([H])([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C2=O)C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C(F)=C3[H])C([H])([H])[H])N(C3=C(N=C([H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])=C(C([H])=C([H])C1=O)C(F)(F)F)C([H])([H])C1=C([H])C2=C(O1)N=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=C([H])C2=C(OC3=C([H])C(Cl)=C(C([H])=C3[H])C([H])([H])[H])C([H])=NC([H])=C2S1
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])[C@@]2(OC([H])([H])C3=C2C([H])=C(F)C(F)=C3[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C([H])=NC3=C([H])C([H])=C([H])C([H])=C23)C2([H])C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])S(=O)(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C(N(C3=C([H])C([H])=C(C([H])=C23)C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2C(SC(C(=O)N([H])[H])=C2N([H])[H])=NC(=N1)N([H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(C([H])=C(F)C([H])=C2[H])C(=O)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C([H])N([H])N=C2[H])C(F)=C1[H]
[H]N([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C1C(=N2)C2=C([H])C3=C(C(=O)N2C1([H])[H])C([H])([H])OC(=O)[C@@]3(OC(=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])[H]
Cc1ccc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)N[C@H](CO)c2ccccc2)cc1Br
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C2=C1C1=C(C3=C([H])N(N=C3C([H])([H])C1([H])[H])C([H])([H])[H])C1=C2C([H])([H])N([H])C1=O)C(=N\OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])=C(C2=C([H])C([H])=C(Br)C([H])=C2[H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C(Cl)=C1[H]
[H]N(C(=O)C1=C2N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C(N2N=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1
[H]N(C1=NC([H])=C([H])C(=N1)N(C(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])[C@]([H])(OC3=NC([H])=C([H])C(C#N)=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])=C(S1)N1N=C([H])C([H])=N1
[H]C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]2([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]2([H])C1([H])[H]
[H]N([H])N([H])C(=O)C([H])([H])SC1=NC2=C(C(=C(S2)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C(=O)C(OC2=C([H])C(N([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2[H])=C([H])C1=O
[H]OC1=C(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])[C@@]1([H])C2=C(OC3=C1C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C(Cl)C([H])=C(Cl)C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])=C([H])C([H])([H])C2([H])[H])=C1[H]
[H]C([H])([H])N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC([H])([H])C1=C([H])N(N=N1)[C@]1([H])O[C@]([H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])[C@]([H])(C1=NC([H])=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=O)C([H])([H])C2(O1)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])=C([H])C(=O)N3C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])S1
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1
[H]N1C([H])([H])C2=C(N(C([H])=C2C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(N1C([H])([H])[C@@]([H])(N(C([H])([H])C([H])=C([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C(=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC(=NC(=N2)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C(=O)C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]N(C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H]
[H]N(C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2C(N([H])C([H])=C2C2=C([H])N=C([H])O2)=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)O[H]
[H]N(C1([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1C([H])=C(N2[H])C([H])([H])N1N=NC([H])=C1[H]
[H]N(C1=C2C(=NN1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1C2([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]OC1=C([H])C(=C([H])C(OC([H])([H])[H])=C1C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])Cl)C1=C([H])C([H])=C(SC2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H]
[H]N=C(N([H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC4=C([H])C([H])=C([H])C(=C4[H])C([O-])=O)[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])SC1=NN=C(N1C([H])([H])C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C(F)(F)F
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])S(=O)(=O)C1=NC(=C([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NOC(=C1[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=C2[H])C1=C([H])N2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])[H]
[H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)C1=NC([H])=C(O1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C(=O)O[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
OC1=CC=C2C[C@H]3N(CCC4=CC=CC=C4)CC[C@@]4(CC5=C(C[C@@]34O)C=C3C=CC=CC3=N5)C2=C1
[H]N(C(=O)N([H])S(=O)(=O)OC1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(N=C(S1)C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C(OC2=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])N=C(N2[H])[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C(=C(C([H])=C2[H])[C@@]2([H])C([H])([H])C(=O)N([H])S2(=O)=O)C([H])([H])[H])C([H])=C([H])C([H])=C1O[H]
[H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C2C(=C(SC([H])([H])C3=C([H])C([H])=C(OC([H])([H])C4=C(C([H])=C(F)C([H])=C4[H])C(F)(F)F)C([H])=C3[H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N(C1=N[C@]([H])(C([H])([H])[H])C([H])([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
[H]ON([H])C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H]
[H]N(C1=NC([H])=C2C([H])=C(C(=NC2=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C([H])(N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1=NC([H])=C(SC([H])([H])C2=NC([H])=C(O2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])S1)C([H])([H])O[H]
[H]N(C1=NC([H])=NC2=C([H])C([H])=C(C#CC([H])([H])N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H]
[H]OC(=O)[C@]([H])(\N=C(/S[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(O[H])=C1[H]
[H]C1=C([H])C(C(=O)C2=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C2C([H])=C([H])C(=C3[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C2N1[C@]([H])(SC2([H])[H])C1=C([H])\[N+](=N\C(=O)C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C2=C1C([H])([H])C([H])([H])N2C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C3=C(C(=NC4=C(C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
CN1C=CC(=N1)C(=O)NC1=CC=C(F)C(=C1)[C@@]1(C)N=C(N)OCC1(F)F
[H]N(C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@@]([H])(C(=O)N1N(C#N)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2=C([H])C([H])=NN2C([H])([H])C1([H])[H]
[H]N1N=NN=C1C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NC(=O)C(N1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
FC1=CC=C(C=C1)C(=O)NCCN1CCN(CC1)C1=NOC2=C1C=CC=C2
[H]ON(C(=O)N([H])[C@@]([H])(C1=NC([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C(F)=C1C1=NOC(=N1)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(SC([H])([H])[H])C(=C2[H])C([H])([H])[H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)O[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C2N(C(=NC2=C([H])C(=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N1N=NC(=N1)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C(=O)[C@@](C([H])([H])[H])(C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C1Cl
[H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C2N(C(=NC2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])(F)F)C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C(\[H])=C1\C([H])([H])N2C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C([H])([H])[C@]1([H])C1=C([H])/N2C4=C([H])C([H])=C([H])C([H])=C4[C@@]45C([H])([H])C([H])([H])N6C([H])([H])C7=C([H])C([H])([H])O[C@@]([H])(N(C8=C([H])C([H])=C([H])C([H])=C8[H])[C@]3\1[H])[C@@]([H])([C@]24[H])[C@@]7([H])C([H])([H])[C@@]56[H]
[H]C1=C2N(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C(=O)C(=C([H])N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1
[H]OC1=C([H])C(N([H])[H])=C(Cl)C([H])=C1C(=O)OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC(=O)C3=C([H])C(Cl)=C(N([H])[H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]ON(C(=O)N([H])[H])[C@]([H])(C1=C([H])C2=C(S1)C([H])=C([H])C([H])=N2)C([H])([H])[H]
[H]OC(=O)C([H])(C(=O)O[H])C([H])([H])C1([H])N([H])C(=O)C([H])([H])SC([H])([H])C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C(=O)C2(N([H])C(=O)C([H])(N([H])C(=O)C([H])(N([H])C1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[H]
[H]C1=C([H])C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=NC2=C1N=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=NN=C2C([H])=C([H])C(=NN12)C1=C([H])C(F)=C(F)C(F)=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H]
[H]N(C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C(F)=C(F)C([H])=C1[H]
[H]OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(OC([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C(C3=C([H])N(N=C3[H])C([H])([H])[H])=C(Cl)C([H])=C2N=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N(C3=C([H])C(F)=C([H])C([H])=C3[H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=NN=C(O1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=C(OC2=C([H])C([H])=C(C#N)C([H])=C12)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(S1)C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=C(C2=NC3=C(N2[H])C([H])=C([H])C([H])=C3[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])N(N=C4[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=NC([H])=C2[H])N1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/OC([H])([H])[H])C(=O)N([H])C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C(Br)=C2[H])C([H])=C1[H]
[H]N(C1=C([H])C(=NS1)C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])N2C1=NC([H])=C2C1=C([H])N(N=C1[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C(=O)N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1Cl)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC(=O)[C@]1(N([H])S(=O)(=O)N2C([H])([H])C3=C(N4C([H])=C([H])C(F)=C([H])C4=N3)C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])[C@@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=O)C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=C(C(=O)O3)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H]
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[H]N(C(=O)C1=C(C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[S@](=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
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[H]N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C1=NC2=C(N1[H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(O[C@@]([H])(OC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H]
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[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=NC([H])=C2[H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2C([H])=C(N=C([H])C2=NC([H])=N1)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
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[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(\C([H])=C2/C(=O)/C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2N=C(N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC([H])([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
COC[C@H]1OC(OCC2=CC=C3C=CC=CC3=C2)[C@H](NCCCN)C(OCC2=CC=C(Cl)C=C2)[C@@H]1O
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1SC([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2S1(=O)=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N1C2=C(SC3=C2C([H])=C(C([H])=C3[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C([H])=C([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C(=O)[C@@]([H])(C1([H])[H])[C@]([H])(OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C4=C(OC([H])([H])O4)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C2N([H])N=C(C3=C([H])C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C2=C1[H]
[H]C1=NC(=NC2=NC(=C([H])C([H])=C12)C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(C#N)=C1[H]
[H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C(=O)N([H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C1=NC2=C(N=C(C([H])=C2[H])N(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C(=N1)N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
O=C(NC1=CC=C(C=C1)C1=CNN=C1)OCC1=CC=CC=C1
[H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]2([H])C1=O)C([H])([H])C([H])([H])[C@@]([H])(OC1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C(F)C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C2N([H])C(=O)N(C2=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])N=C1[H]
[H]ON([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C([H])([H])C([H])([H])[H]
[H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C(=NC([H])([H])C1([H])[H])[C@@]([H])(OC1=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=NC([H])=C(C([H])=N1)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C(F)=C1[H])[C@]([H])(C([O-])=O)C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N1C2=C(C3=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@]3([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(C(=O)C1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(N=C1[C@@]1([H])N(C(=O)[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]C1=C(C2=C(S1)N=C(OC2=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C([H])(C(=O)O[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])=C([H])C3=C2C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C1=C(N([H])C([H])=N1)C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=C([H])C2=C([H])C(F)=C([H])C([H])=C12)C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N(C1=C2N=C(C([H])=C([H])C2=NC([H])=N1)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C(OC([H])([H])[H])C([H])=C([H])C(Br)=C2[H])N=C(SC([H])([H])C([H])([H])[H])N=N1
[H]O[C@@]1([H])C2=C(O[C@]3(C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[C@@]4([H])[C@]5(C([H])([H])[H])C([H])([H])OC(O[C@@]5([H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@]13[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(OC2=O)C1=C([H])N=C([H])C([H])=C1[H]
[H]OC(=O)C1=C(O[H])C([H])=C2OC(=C(C3=C([H])N(N=N3)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C(Cl)C([H])=C3[H])C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C(=C([H])N3C2=NC(=C3C([H])([H])[H])C([H])([H])[H])N2N=C([H])N=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])S[C@@]([H])(SC([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2C([H])=C1[H]
[H]OC1=C([H])C(=NC2=C(O[H])C([H])=C([H])C([H])=C12)C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC1=C([H])C(=NC2=C(O[H])C([H])=C([H])C([H])=C12)C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H]
[H]C1=NN(C(=O)C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1Br)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2C2(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]C1=NC([H])=C(C(OC2=C([H])C([H])=C(Cl)C([H])=C2OC([H])([H])[H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1C(=O)C2=C(ON=C2C2=C1C([H])=C([H])C([H])=C2Cl)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C(C(=O)OC([H])([H])C([H])([H])[H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=NC2=C(N=C(C(=O)N2[C@@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C(Cl)=NC([H])=C2[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1(O[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C(N([H])S(=O)(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H]
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[H]OC1=C([H])C([H])=C([H])C([H])=C1C1=NC(=NC(=N1)C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H]
[H]N([H])C1=C2C(=NC3=NN(C([H])=C13)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
CC1=C(N(N=C1C(=O)NCCCCCNCCCCCN)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(Cl)C=C1
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[H]N(C(=O)OC([H])([H])C1=NC([H])=C([H])N1[H])[C@]([H])(C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C(=C([H])C([H])=C2C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=C1C(=O)OC([H])([H])[H])S(=O)(=O)C([H])([H])[H]
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[H]N(C1=C(Cl)C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H]
[H]N(C(=O)N([H])[C@](C1=C([H])C([H])=C(Cl)C([H])=N1)(C1=C([H])C(F)=C([H])C(OC(F)(F)C([H])(F)F)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H]
[H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(C1=NC2=C(N=C([H])N(C2=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])N([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C1C([H])=C([H])C1=C([H])C(=C([H])C([H])=C21)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C2=C([H])C([H])=C(N=C12)C1=C([H])C([H])=C2OC([H])([H])OC([H])([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
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[H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])[C@@]([H])([N+]([H])([H])[H])C([H])([H])C2=C(F)C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(C([H])([H])OC(=O)C([H])([H])[H])(C([H])([H])OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]\C(=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N([H])[H])N([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C(N([H])C1=NN([H])C(=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(C#N)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)OC([H])([H])C#CC([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=NC([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])OC1=C2N(C([H])=NC2=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1
[H][C@@]12C[C@]1([H])N([C@@H](C2)C#N)C(=O)[C@@H](N)C1CCN(CC1)S(=O)(=O)CC1=CC=CC=C1
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[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C([H])=C([H])S1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=NN(C1=O)C([H])([H])[H]
[H]N([H])C(=O)C1=C(OC([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C(S1)C1=C2C([H])=C([H])C([H])=C([H])N2N=C1[H]
C\C(NNC(=O)N1CCC2=C1C=CC(=C2)C(O)=O)=C1/C(C)=NN(C1=O)C1=CC=C(C)C(C)=C1
[H]OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C(=C([H])N2C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])N2N=C(N=C2C(=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC1=C2N=NN=C2N=C2SC([H])([H])C([H])([H])N12
[H]N(C(=O)C1=C([H])N=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])C2=C(SC3=C([H])C([H])=C(Cl)C([H])=C3[H])C3=C(C([H])=C(F)C([H])=C3N2C([H])([H])C1([H])[H])[C@]([H])(O[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(N([H])C(=O)C2=C([H])C([H])=C(O2)C#N)=C1[H]
[H]N(C1=C2N=C([H])N(C2=NC(=N1)C#N)C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])C([H])(F)F
[H]N(C(=O)C1=NC([H])=C2N1C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1N=C2N([H])C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])C1=C([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])[H])C([H])=C([H])C([H])=C2S1
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[H]N([H])C1=C(SC(=N1)C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC(=C([H])N2C([H])=C([H])N=C12)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C#N
[H]N1C(=O)C(=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])SC(=N1)C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(C1=C2C([H])=C([H])C([H])=C1[H])=C1C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C(Br)=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(OC2=NC(OC3=C([H])C([H])=C4OC([H])([H])OC4=C3[H])=C(C([H])=N2)C([H])([H])[H])C([H])=C1[H]
[H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(\S[H])=N\C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
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[H]OC1=NC(=NN1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@]([H])(O[C@@]([H])(C2=C([H])C(F)=C([H])C(=C2[H])C(F)(F)F)C([H])([H])[H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C(F)(F)F)C(F)(F)F
[H]C1=C([H])C([H])=C2C(=O)OC(=NC2=C1[H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(N([H])[H])=C1[H]
[H]N([H])C(=O)C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C2=C(N([H])C(=O)\C2=C(\[H])C2=C([H])N(C3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])=C1[H]
[H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C(N=C2SC(=C([H])N12)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(=C1[H])[N+]([O-])=O
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C2N(C3=C([H])C([H])=C([H])C([H])=C3N2C1=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(\[H])=C(/[H])C2=C([H])N=C([H])C(C#N)=C2N([H])C2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2O[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)[C@@]4([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2
[H]N(C1=C2SC(C#C[C@@]3([H])N([H])C([H])([H])[C@]([H])(OC(=O)N([H])C([H])([H])C([H])([H])[H])C3([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C1=C2C([H])=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3=C4C([H])=C([H])C([H])=C(C4=NC([H])=C3[H])C(F)(F)F)C2=C([H])C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H]
[H]C1=NC2=C(C([H])=C1[H])N1C(=NC(=C1C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H])N2C1=C(Cl)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[C@@]2([H])SC2([H])[H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(\N=C1/C(O[H])=C(O[H])\C/1=N/C([H])([H])C([H])=C([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H]
[H]N1C(=O)C([H])([H])[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(S1)C1=C2C(=NN1[H])C1=C([H])C(=C([H])C([H])=C1C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]C1=NN(C2=C1C(=NC([H])=N2)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H]
[H]C1=C([H])C2=C(C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21SC([H])([H])C(=O)N1C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC(=C([H])C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(F)(F)F
[H]C1=NC2=C([H])C(=C([H])C([H])=C2N1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])Br
[H]N(C(=O)[C@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2O[C@]1([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C2N=C3C(C([H])=C([H])C([H])=C3C#N)=C2C([H])=C(N1C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H]
[H]C1=C(C2=NC(=C(N2N=C1C([H])([H])[H])C1=C(Cl)N=C(S1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C(/[H])S(=O)(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]OC1=C(C#N)C2=C(F)C([H])=C([H])C([H])=C2C(SC([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])=N1
[H]N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C1[H]
[H]C1=C([H])C([H])=C2C(=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H]
[H]C1=C([H])C(Br)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C(C([H])=C(C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C(\[H])=C(/[H])C#N)C1=C(C([H])=C(Cl)C([H])=C1[H])C(F)(F)F
[H]N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C2C(=C1[H])[C@@]([H])(C([H])([H])C([H])([H])C2([H])[H])C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C([H])([H])N([H])C1=NC([H])([H])C([H])([H])N1[H]
[H]N1C(=O)S[C@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C([H])([H])C([H])([H])SC(=O)C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(Cl)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H]
CC(C)(C)C[C@@H]1N[C@H]([C@H](C2=C(F)C(Cl)=CC=C2)[C@]11C(=O)NC2=C1C=CC(Cl)=C2)C(=O)NCCN1CCOCC1
[H]C1([H])N(C1([H])[H])P(=O)(N1C([H])([H])C1([H])[H])N1C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=S)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C(OC(=O)C([H])([H])[H])C([H])=C([H])C(Cl)=C2[H])N=C(SC([H])([H])C([H])([H])[H])N=N1
[H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O
[H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])C([H])([H])C3=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C2=C([H])C(F)=C([H])C([H])=C12
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C2N(C(=O)C(=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=NC(=NC2=C(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=NN1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]