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[H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]C([H])=C([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C2([H])[H]
[H]OC(=O)C([H])([H])N1C(=O)S\C(=C(/[H])C2=C([H])OC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=O
[H]C([H])=C([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)[C@@]1([H])N([H])[C@]([H])(SC1([H])[H])C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])\C1=C([H])N=C([H])C([H])=C1[H]
[H]N([H])C1=C([H])C(=NC([H])=N1)N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C(=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(F)(F)F)=C([H])C([H])=C1C([H])([H])[H]
[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(N(C3=C([H])N=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(OC([H])([H])C([H])([H])O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C(Cl)N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=NN([H])N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1N=C(C2=NC3=C(N2[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(Br)=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=S)N(C1=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F
[H]N(C(=O)[C@]12C([H])([H])C([H])([H])[C@@](C(=O)[C@@]1([H])Br)(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C1=O
[H]N(C(=S)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C2=O
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=NN1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[C@]1([H])N1C(=O)C([H])([H])[C@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H]
[H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N1N=C([H])C(=C1[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])N2C2=NC3=C(S2)C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=NN([H])C([H])=C21)C1=NN([H])C(=C1[H])C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])N(C#N)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C(N=C1[H])N([H])[H]
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[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)[C@@]1(F)[C@]2([H])C([H])([H])[C@@]([H])(OC([H])([H])C([H])=C([H])[H])[C@@](N([H])[H])(C(=O)O[H])[C@]12[H]
[H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2S1)C1=C([H])C([H])=C(C(=O)N2C([H])([H])[C@]3(C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C(Cl)=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4Cl)C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=S)C1=C(ON=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C(F)(F)F
[H]N(C(=O)N(C1=C(F)C([H])=C(F)C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N3C4=NC5=C(N4C([H])([H])C([H])([H])C3([H])[H])C(=O)N(C(=O)N5C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2N1[H])C(=O)N([H])[H]
[H]OC1(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])OC2=C([H])C([H])=C3C(=C2[H])C([H])=C(C([H])=C3C2=C([H])OC([H])=C2[H])C2=NC([H])([H])C([H])([H])O2)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
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[H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(N=C2N1[H])C1=C([H])N([H])N=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H]
[H]OC1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C(N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H]
O=C(CSC1=NC(C2=CC=CC=C2)=C(N=N1)C1=CC=CC=C1)C1=CNC2=C1C=CC=C2
[H]N(C1=NC(OC([H])([H])C([H])([H])[H])=NC(=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(Br)C([H])=NN2C(N([H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C([H])C(C(=O)C2=C([H])C(C([H])=O)=C([H])C(O[H])=C2C([H])=O)=C1O[H]
[H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=NC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C(Br)=C([H])C([H])=C1[H])C(\[H])=C1/C([H])=C(C([H])=C([H])C1=O)[N+]([O-])=O
[H]C1=NC(=C([H])C([H])=C1[H])C1=NN=C(N1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C(=O)C([H])([H])OC2=C(C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1N([H])C(N([H])C1=S)=C1C([H])=C([H])C(=O)C([H])=C1[H]
[H]OC(C(=O)N([H])C([H])([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(C([H])=C3[H])C([H])([H])SC4([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])S(=O)(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=NOC(=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C2C(=N1)C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C1=NC([H])([H])N(C(=N1)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(S1)C(O)(C(F)(F)F)C(F)(F)F
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[H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC(=O)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H]
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[H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(OC([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1O[H])C(\[H])=C(/[H])C1=C([H])C([H])=C(F)C(F)=C1[H]
[H]N1C([H])=C(N=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=NC([H])=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C(=O)C1=C(N([H])C2=C([H])C(Cl)=C(OC([H])([H])[H])C([H])=C2[H])C2=C(N=C1[H])C([H])=C(C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)S(=O)(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]N([H])C(=NS(=O)(=O)C1=C([H])C([H])=C(\N=C(/[H])C2=C([H])OC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])([H])[H])C([H])=C1[H])N([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(OC2=C([H])C3=C(OC(=N3)N([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])=C([H])C([H])=N1)C([H])([H])[H]
[H]C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C2C([H])=C(C([H])=NC2=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O
[H]N(C(=O)C([H])([H])C([H])([H])[H])C1=NC(=C([H])C(=N1)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]C1=NC([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C#N)C(OC3=C([H])C([H])=C(C#CC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C3[H])C([H])([H])N3C(=O)C([H])([H])[N@@](C([H])([H])C3([H])[H])C2([H])[H])=C1[H]
[H]OC(=O)C1=C(OC([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(C(=NN2[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C1=C(F)C(=C(F)C(=N1)N(C1=C([H])C(=C([H])C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[C@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])S1
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])[H]
[H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])N(C([H])([H])[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]2(C(=O)OC([H])([H])C([H])([H])[H])C(=O)[C@]1(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C2([H])[H]
[H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)[S@@](=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(OC([H])([H])C([H])([H])O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1C2=O
[H]N([H])C1=NC(N([H])[H])=C(C2=C([H])C(\N=N\N(C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)C([H])([H])C([H])([H])OC(=O)C([H])([H])[H])=C(Cl)C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H]
[H]N1C(=O)S[C@@]([H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N([H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])([H])C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2N=NC(=N2)C2=C([H])C(=NC(=C2[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])[C@]2(C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OP(=O)(OC2=C([H])C([H])=C(N([H])C(=O)C([H])([H])N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@]2([H])N(C(=O)[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[N+]3([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C(C(=C2N=C1C([H])([H])[H])C1=C(C([H])=C(N=C1C([H])([H])[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NSN=C23)C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C(Br)=C1[H]
[H]C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2C([H])([H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C3=C2C([H])=C([H])O3)C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])C([H])([H])OC1=C(C#CC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C2N([H])C(=O)C([H])([H])C(=NC2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=NC([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]1([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2C(O[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]N(C(=O)N(C1=NN(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@@](O[H])(C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]1(C2=NC([H])=C([H])S2)C([H])([H])C([H])([H])[C@]([H])(N([H])[C@]2([H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
CC[C@H]1N=C(N)[Se][C@H]1C
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1N=C(C(=C1N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C1=C(C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]OC1(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C(=O)N([H])[C@@]2([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]2([H])C4([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[C@]1([H])OC1([H])[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(\N=C1/C(=O)N([H])N=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C3[H])=N1)C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C(C([H])=C(S2)C2=C([H])C([H])=NC([H])=C2[H])C1=O)C1=C([H])C([H])=C([H])C(Cl)=N1
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])C1(F)F)C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=N2)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C1=C(N=C(S1)C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C(OC([H])([H])C([H])([H])[H])=NC(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(N=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
Cl.COC1=C(OC)C=C2C(=O)[C@@H](CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1
[H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(I)S1)C([H])([H])[H]
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[H]N([H])C1=N[C@@]([H])(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(C(=O)OC([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H]
[H]N(C(=O)C1=C(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C(N1[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C(=NN1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])N(C(=O)C([H])([H])[H])C2([H])[H])S(=O)(=O)C([H])([H])[H]
[H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2N=C([H])C(=N2)C2=C([H])C(F)=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C(=S)N(C(=O)C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F)C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]N1C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C(=NO1)C([H])([H])[H]
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[H]N([H])C(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC([H])=C1C#N)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
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[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[C@]([H])(C([H])([H])[H])C(F)(F)F)[C@@]23[H])C([H])([H])[H])C1([H])[H]
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[H]N(C(=O)OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2N1C(=O)[C@]2([H])[C@]([H])(C1=O)[C@]1([H])C([H])=C([H])[C@@]2([H])N(C1=O)C([H])([H])[H])[N+]([O-])=O
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[H]N(C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)O[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN([H])C([H])=C1[H]
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[H]N(C1=NC2=C3C(=O)N([H])C(=O)[C@@](C3=C([H])C([H])=C2N1[H])(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N1C(=O)N([H])\C(C1=O)=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
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[H]N([H])C1=C(SC2=NC(=C([H])C(=C12)C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1F
[H]N([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C([H])([H])N([H])[C@]([H])(C(=O)N2C([H])([H])SC([H])([H])C2([H])[H])C1([H])[H]
[H]N1C([H])=C([H])C2=C3C(=O)N([H])C(=O)C3=C([H])C([H])=C12
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1C([H])([H])[H]
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[H]N=C(OC([H])([H])[H])N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(N([H])C2=C([H])C([H])=C3C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C3=O)=C2[H])=C1[H])C([H])([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=NC2=C(S1)C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H]
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[H]OC1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C(=C(O[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])C(F)(F)C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
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[H]N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H]
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[H]N(C1=NC(=O)[C@]([H])(S1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C2C([H])=C([H])N([H])C2=C([H])C([H])=C1[H]
[H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(SC4=NC([H])=C([H])S4)C([H])=C3[H])C2=C1[H]
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[H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]OC(=O)C1=C([H])N(C2=C1C([H])=C(C([H])=C2[H])C1=C(C([H])=C(OC([H])([H])C2=C(ON=C2C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])([H])C2=C([H])C([H])=C([H])C3=C2[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2C3([H])[H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])N([H])C1=O)C(=O)N(C([H])([H])[H])C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])S(=O)(=O)C1=NC([H])=C(C([H])=C1[H])C(F)(F)F
[H]N(\N=C(/C1=C([H])C([H])=C([H])O1)C([H])([H])[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]\C(C#CC1=C([H])C([H])=C([H])C(F)=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H]
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[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=NN(N=N1)C(=O)N(C([H])([H])[H])C([H])([H])[H]
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CC1(C)CC(=O)NC1(C)C#N
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C(=O)C2=C(O[H])C3=C([H])C([H])=C(C([H])=C3N=C2O[H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H]
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[H]N1N=C(N=C2N([H])C([H])([H])C([H])([H])N2[H])C2=C1C([H])=C([H])C([H])=C2Cl
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C([H])N=C1[H]
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[H]N(C([H])([H])C([H])([H])OC1=C2OC([H])([H])C([H])([H])OC2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(F)C([H])=C2[H]
[H]N(C1=NC(Cl)=C([H])N(C1=O)C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C1=C(Cl)C([H])=C(OC([H])([H])C([H])([H])F)C([H])=C1Cl
[H]N([H])C1=NC2=C([H])C3=C(C([H])=C2S1)C([H])([H])[C@@]1([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]32C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
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CCCCNC(=O)C1=CC=C2N(CCCOC)C(NC(=O)C3=CC=CC(=C3)C#N)=NC2=C1
[H]OC1=C(C([H])=C(Cl)C([H])=C1Cl)C(=O)N([H])C1=C([H])C([H])=C(SC2=NC3=C(S2)C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C1[H]
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[H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C([H])N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H]
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[H]OC(=O)C([H])([H])[C@@]([H])(SC1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C([H])=NC([H])=C1C#N)C1=C([H])C2=C([H])C(=C([H])C([H])=C2O1)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])N([H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=N1)N1N(C(=C(C1=O)C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C#CC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C(F)C(F)=C([H])C([H])=C4[H])=C3C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
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[H]C1=C([H])C([H])=C2C(=C1[H])C([H])=C(C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H]
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[H]OC1=C(N([H])C2=NSN=C2N([H])[C@@]([H])(C2=C([H])C([H])=C(O2)C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
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[H]N(C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(Cl)C([H])=C(F)C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C1=NN=C(O1)C1=C([H])N2N=C([H])N=C(N([H])C3=C(F)C([H])=C(F)C(=C3[H])C(=O)N([H])C3([H])C([H])([H])C3([H])[H])C2=C1C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=NC(=NC([H])=C2C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])C#CC2(O[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)C1=C(C([H])([H])SC2=NN=NN2C([H])([H])[H])C([H])([H])O[C@@]2([H])N1C(=O)[C@@]2(OC([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C([H])([H])C1=C([H])C([H])=NC(N([H])C([H])([H])[H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H]
[H]N(C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)[C@]1([H])N2C(=O)[C@]([H])(N(C(=O)C(F)(F)F)C([H])([H])[H])[C@@]2([H])S(=O)(=O)C1(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1OC1=NC(OC2=C([H])C(=C([H])C(=C2[H])C([H])([H])N([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])N([H])[H])=C(F)C([H])=C1F)C([H])([H])[H]
[H]N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C#N)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
Cc1csc(Nc2ncc(C)c(n2)-c2c[nH]c(c2)C(=O)N[C@H](CO)c2cccc(Cl)c2)n1
[H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)O[C@]2([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])[C@@]2([H])N([H])C(=O)C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H]
C\C(=N/OCC1=CC(=C(C=C1)C1=CC(F)=C(F)C=C1)C(F)(F)F)C1=CC=C(CNCCC(O)=O)C=C1
[H]N(C1=NC(=C([H])C([H])=N1)N1C([H])=C([H])N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NC([H])=C([H])N=C1[H]
[H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(S[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC(=O)[C@]2(C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@]4([H])C(=C([H])C([H])([H])[C@@]23[H])[C@@]2(C([H])([H])O[H])C([H])([H])[C@]3([H])OC(=O)[C@]([H])(C([H])([H])C(=O)C([H])=C(C([H])([H])[H])C([H])([H])[H])[C@@]3([H])[C@]2(C([H])([H])[H])[C@@]([H])(O[H])C4([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C([H])C(OC(F)(F)F)=C([H])C([H])=C3[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C2C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])C1=C2S[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C1=C([H])N(C2=C(F)C(N([H])C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(F)C(N([H])[H])=C2C1=O)C1([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NN=C(S2)C2=C([H])N=C(C([H])=C2[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H]
[H]OC1=C2\C(=C(\[H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(=O)O[C@]([H])(C([H])([H])OC([H])([H])[H])[C@@]2(C2=C(C1=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]1(C([H])([H])[H])C([H])([H])[C@@]2([H])OC(=O)C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N=NN1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=O)N(C1=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1C#N)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1N=C([H])C([H])([H])[C@@]1([H])C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H]
[H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C(=O)O[H])C(=O)O[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C2=C(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3OC2=O)C([H])([H])C1([H])[H]
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[H]OC1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C(=O)N([H])C2=NN=C(S2)S(=O)(=O)N([H])[H])C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl
[H]N(C1=NC(OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C([H])C([H])=N1)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(OC([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C(Cl)C([H])=C2Cl)C1([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C(F)C([H])=C([H])C([H])=C4[H])=C3C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C(Cl)C(OC([H])([H])C(=O)N(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C(Cl)=C1Cl
[H]N1C([H])=NC([H])=C1C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2N([H])C1=O
[H]N(C(=O)C([H])([H])[C@@]1([H])S[C@@]([H])(N(C1=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])O1
[H]N(C1=C2C([H])=NN(C2=NC(=N1)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC1=C(CCOCCO)C=C(N1C1=CC=C(F)C=C1)C1=CC=C(C=C1)S(C)(=O)=O
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(C(=O)C2([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C(OC([H])([H])C3=NC([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])S1
CC(C)Nc1cc(ncn1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1cccc(Cl)c1
[H]C1=C(SC(=N1)C1=C(Cl)C([H])=C([H])C([H])=C1[H])[C@@]1([H])N(C(=O)[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C(I)=C1[H])C1=NC(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])F
[H]C1=C([H])C2=C(S1)[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC([H])=NC2=C1C(=NN2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2F)C(F)(F)F)C([H])=C1[H]
[H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])SC4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C(=O)C([H])([H])Br)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])=C([H])C2=C1N=C(N=C2[H])N([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(N([H])S(=O)(=O)C4=C([H])C([H])=C([H])C(=C4[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C([H])([H])C2([H])[H]
Cc1ccccc1C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12
[H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=NN=C(O2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC4=C(N=C3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C([H])([H])C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C#N
[H]N(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1(N([H])C([H])([H])C(=O)N2[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]2([H])C#N)C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(ON=C1[H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C(Cl)=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])=C(O1)C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(OC([H])([H])C([H])([H])OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])=C2[H]
[H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=C(N=C(S2)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1F
[H]N(C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)O2)C([H])([H])[H]
[H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C(F)C(F)=C([H])C([H])=C4[H])=C3C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=NC2=C(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(O[H])=C([H])C(O[H])=C12
[H]OC(=O)C(=C(/[H])C1=C(C#N)C([H])=C([H])C(OC([H])([H])C2=C([H])SC([H])=C2[H])=C1[H])\C1=C(Cl)C([H])=C([H])C([H])=C1[H]
[H]OC1=C(Cl)C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])=C1Cl
[H]N([C@@]([H])(C1=NN(C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C([H])([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])I
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(N(C3=C([H])N=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(C(F)=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NN=C(C2=C1C([H])=C1C([H])=C([H])C([H])=C([H])N21)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C(C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1OC([H])([H])[H]
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H]
[H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])N([H])C2=C(F)C([H])=C([H])C(=C2[H])C(F)(F)F)=N1
[H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C1=O)[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]O[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=O
[H]C1=C(N=NN1C([H])([H])[H])[C@@]([H])(N(C1=C([H])C(Cl)=C(C#N)C([H])=C1[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C2C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C4OC([H])([H])C(=O)N(C4=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])N(C2=C([H])C(=NC(=N2)N2C([H])=NC([H])=C2[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H]
[H]N(C(=O)C1=C(SSC2=C(C(=O)N([H])C([H])([H])[H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C(C([H])=C([H])C(SC2=C([H])N=C(S2)N([H])C2=NC([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2(C3=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])[C@]12[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@@]1([H])C([H])([H])N(C(=S)C([H])([H])C1([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C(S1)C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C(=O)O[H]
[H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C(F)=C(F)C(F)=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C2([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])N=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C([H])N2[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])N([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C2=C([H])C([H])=C([H])N=C2N(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C1=O
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[H]OC(=O)C(=N\O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1SC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])\C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=C(C2=C1C([H])=C(F)C(Cl)=C2[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12
[H]OC1=C([H])C([H])=C(N([H])C2=C3N=C([H])N([H])C3=NC([H])=N2)C([H])=C1C([H])([H])N(C([H])([H])C([H])([H])Cl)C([H])([H])C([H])([H])Cl
[H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=C([H])C2=C(C([H])=NN2[H])C([H])=C1[H]
[H]OC(=O)C(=O)[C@@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])=NC2=C([H])C([H])=C([H])C([H])=C12
[H]OC([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C(Cl)=C([H])C([H])=C3N2[H])C([H])=N1
[H]N(C(=O)OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C([H])([H])C([H])([H])\C3=N\C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C3=C([H])N=C4N=C(OC4=C3[H])N3C([H])([H])C([H])([H])C([H])(N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C2=N1
[H]N1C2=C([H])C([H])=C(C([H])=C2C(O[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])SC(C#N)=C1[H]
[H]N(C(=O)C1=NN(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1N(C([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])C1=O
[H]O[C@]([H])(C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3=C([H])C4=C(N=C(O4)C4=C([H])C(=NN4C([H])([H])[H])C([H])([H])[H])C([H])=C3C([H])([H])C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[C@]([H])(N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])O1
[H]OC(=O)[C@@]([H])(\N=C1/C(O[H])=C(O[H])\C/1=N/C([H])([H])C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=NC([H])=C2Cl)C([H])=C1[H]
CN1CCN(CC1)C1=CC(=CC(COCC2(CCNCC2)C2=CC=CC=C2)=N1)C(F)(F)F
[H]C1=C([H])N2C(=C1[H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C(SC1=C(Cl)C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=NC(=C([H])C2=C1C(=O)OC1=C([H])C([H])=C([H])C([H])=C21)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C1=C(C([H])=NC([H])=N1)C1=C([H])C([H])=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(N1C3=C(N=C1C([H])([H])[H])C([H])=C([H])C([H])=N3)C2([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]N1C2=C([H])C(=NN2C2=C([H])C([H])=C([H])C([H])=C2C1=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])N(C3=C([H])N=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(OC([H])(F)F)=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C1=C([H])C(=O)N2C([H])=C(Br)C([H])=C([H])C2=N1
[H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N(C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(Cl)C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1
[H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C([H])([H])C(=NC([H])([H])[C@]11C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])[N+](=C(N1C([H])([H])[H])P(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N([H])[C@]([H])(C1=C(C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])OC([H])([H])[C@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1N=C(OC([H])([H])[H])C2=C([H])C([H])=C3OC([H])=C([H])C3=C12
[H]N1C(=O)\C(=C(\[H])C2=C(C3=C(N2[H])C([H])([H])C([H])([H])N(C3=O)C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])[H])C2=C([H])C(F)=C([H])C([H])=C12
[H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)C(=O)N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])[C@]4(OC(=O)N(C([H])([H])C5([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])[C@@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=NN2C([H])=C1C1=C([H])C([H])=C([H])C(Cl)=C1F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2([H])[H]
[H]C1=C(N=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C(C#N)C([H])=NN2C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C12)C([H])([H])OC([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C2=NC3=C(N=C(N=C3N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])[H])N2[C@@]2([H])C([H])([H])OC([H])([H])C2([H])[H])C(Cl)=C1[H]
[H]O[C@@]1([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H]
[H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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[H]OC1=NC2=C([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])C4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C([H])C([H])=C3N([H])C2=N1
[H]\C(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C1/C(=O)C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])N(C(=O)C2([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])C([H])([H])[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C([H])([H])C2=C([H])C([H])=C([H])C(I)=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
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[H]N(C([H])([H])C1=NN=NN1C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(C(=O)OC1=C([H])C([H])=C2C(=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H]
COC1=CC=C(C=N1)C1=CC=C2N=CC3=C(N(C4CCN(CC4)C(C)=O)C(=O)N3C)C2=N1
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])SC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([O-])=O)C3=C([H])C(F)=C([H])C([H])=C3N=C21
[H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC([H])=C([H])C([H])=N2)C1([H])[H]
[H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C(Cl)=C([H])C(Cl)=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C(=C(N([H])C(=O)C2=NC([H])=NC(=C2[H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H]
[H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C1=C2OC([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C(F)(F)F
[H]OC(=O)C1=C(C(=NC2=C1C([H])=NC([H])=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC2=C(N=C([H])N=C12)N([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=CC=C1C)C(N)=O
COC1=CC2=C(CN(CC3(NC(=O)NC3=O)C#CC3=C4CCC5(NC(=O)NC5=O)C4=CC=C3)C2=O)C=C1
[H]N([H])C1=NC2=C(SC(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])N2C1=NC([H])=C2C([H])([H])[H]
[H]OC1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])O[H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1[H]
[H]N(C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=NC(=NN12)C([H])([H])C([H])([H])C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C([H])C([H])=C([H])C2=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1=C(Cl)C([H])=NC([H])=C1Cl
[H]N([H])C(=O)C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H]
[H]N([H])C1=NN([H])C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])=C1[H]
[H]C1=C([H])C(Cl)=C(C([H])=C1[H])C1=NC(=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(N(C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C(C([H])=NN3C([H])([H])C([H])([H])[H])C(=N2)N2C([H])([H])[C@@]3([H])O[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=NC([H])=C1[H]
[H]OC(=O)C1=C([H])N(N=C1C([H])([H])C1=C([H])C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NS2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C(C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@]([H])(O[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2C([H])([H])[H])C([H])=C1[H]
[H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C3N=C([H])SC3=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1(C(=O)N(C2=C([H])C(=C([H])C(=C12)C(F)(F)F)C(=O)N([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H]
[H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C2OC(=NC2=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N1N=NN=C1C1=C([H])C([H])=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(SC([H])([H])[H])=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1
[H]OC1=C([H])C2=C(C([H])=C1OC([H])([H])[H])C(=C([H])N2[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@@]([H])(OC1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=NC([H])=N1
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C(=N[H])N([H])[H]
[H]N([H])[C@@]1([H])C([H])([H])N(C2=NC([H])=NC(=C2[H])C2=C([H])SC([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F
[H]N(C(=O)C([H])([H])[C@@]1([H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C(C([H])=C(C2=C1C(=O)C([H])([H])[C@]([H])(O2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=NN1C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])N=C(S1)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(O[H])C([H])=C2C(=C1[H])[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N=C(N([H])[H])N1N=C([H])C([H])=C1[H]
[H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])N(C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(N([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]SC1=NN=C(S1)N([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(OC([H])([H])[H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC2=NC([H])=C(N=C12)C1=C([H])C([H])=C(F)C([H])=C1[H]
OC1=CC2=C(NC3=C2CCN(C3)C(=O)OC2=CC=C(C=C2)C2=CC=CC=C2)C=C1
[H]N(C(=O)[C@]([H])(N1C(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(O1)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C([H])N2C3=C(OC([H])([H])C([H])([H])C22C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(N([H])C([H])([H])C([H])([H])N([H])C2=NC([H])=C([H])C([H])=C2[H])=C(F)C(N([H])[H])=C3C1=O
[H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=NC([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C(=O)[C@@]21[H]
[H]N([H])C1=C(C([H])=C(C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C(\[H])=C(/[H])\C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C2=C(C#N)C3=NN=C(N3C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(OC(=O)C([H])([H])[H])=C(SC([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C3=C(C([H])=C([H])C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@@]1([H])[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@]12[H]
[H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=C([H])S2)C1=S)C1=C([H])C([H])=C([H])O1
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1F)N(C([H])([H])[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H]
[H]N1C2=C(C3=NC(Cl)=C([H])C(=C3C([H])=C2[C@@]([H])(C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)C([H])([H])[H]
[H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=C([H])C(C#N)=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(N([H])C(=O)C([H])([H])C2([H])[H])C([H])=C1[H]
[H]N(C(=O)[C@@]1([H])N(C2=NN3C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl
[H]C([H])=C([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1O[C@]([H])(C1=NC([H])([H])C([H])([H])N1[H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(O[H])C([H])=C2[H]
[H]C1=C([H])C(C2=NN=C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C4=C([H])C5=C(N=C(O5)C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])=C4C([H])([H])C3([H])[H])N2C([H])([H])[H])=C2C([H])=C([H])C(=NC2=C1[H])C([H])([H])[H]
[H]OC1=C(C#N)C([H])=C([H])C([H])=C1N([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)C1=O
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])SC1=C(Cl)C([H])=C([H])C(=C1[H])C1=NN(C2=C1C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C([H])=C([H])C([H])([H])N2N1C(=O)N(C2=O)[C@@]([H])(C(=O)OC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])SC1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H]
[H]N(C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C2=N[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3Cl)C([H])([H])C([H])([H])S2)C([H])=C1[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C(=O)C3=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])=C([H])N3C([H])([H])[H])=C([H])N1C([H])([H])[H])C2([H])[H]
[H]ON([H])C(=O)C([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2[C@]([H])(C(=O)N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])O[H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])O[H]
[H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N1C(=O)[C@@]2([H])N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])([H])[H]
[H]N([H])C1=NON=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])[H])C([H])([H])[C@@]1([H])OC([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]1([H])OC1=C([H])C([H])=C([H])C([H])=C1Cl
[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])\N=C(/S[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C#CC1=C([H])C(=C([H])S1)C1=NN([H])C2=C1C([H])([H])C1=C2C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C(C([H])=C(C(=C1[H])S(=O)(=O)C([H])([H])[H])[N+]([O-])=O)C1=NC(=C(S1)C(=O)N1C([H])([H])[C@@]2(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C2N=C([H])C([H])=C([H])N2N=C1[H])C1=C([H])N(N=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/[H])\C(\[H])=C(/[H])C2=NC3=C(O2)C([H])=C([H])C(=C3[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C([H])C([H])=C([H])C(Cl)=C1N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
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[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C4N=C([H])C([H])=C([H])C4=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H]
[H]N1C(=O)N(C2=C(C(=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C(=C([H])N2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(O[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(C(=C1[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]C([H])([H])N1C2=C(N3C(=N2)N(C([H])([H])C([H])([H])C3([H])[H])C2([H])C([H])([H])C2([H])[H])C(=O)N(C1=O)C([H])([H])[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])N=C(SC([H])([H])C([H])([H])[H])N=N1
[H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C2N([H])C(=NC2=C1[H])C1=C([H])C(=C([H])C(=C1[O-])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])[C@]([H])(C([O-])=O)C([H])([H])C([O-])=O
[H]OC1=C2O[C@]3(C(=O)C([H])([H])C([H])([H])[C@@]4(OC([H])([H])C([H])([H])C([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])[C@]5([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H]
[H]OC1=C2C(=NC3=NC(SC([H])([H])[H])=NN13)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]O[C@@]1(C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])[C@]2([H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@](O[H])(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])=NC2=C(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])N=C(N=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2(C([H])([H])C2([H])[H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OP(=O)(O[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1P(=O)(O[H])O[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)C(S[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(N=C(N=C2[H])N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])(O[C@@]1([H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])[C@]1([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C21