[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]1(O[H])C([H])([H])[H])C([H])([H])OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C2=C(O[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2S1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N1C(=O)[C@]([H])(N([H])C(=O)N2C([H])([H])C([H])([H])C3(C4=C(C([H])=C([H])C([H])=C4[H])N(C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C(=C([H])C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C(Br)=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(OC([H])([H])C(=O)N([H])[H])=C3[H])C([H])([H])C([H])([H])N2N=C1C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C1=C([H])C(=O)C(O[H])=C([H])O1 [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]N([H])S(=O)(=O)C1=NN(\C(S1)=N/C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=S)C(C#N)=C(C2=C([H])C([H])=NC([H])=C2[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C1=NC(=NC2=C([H])C([H])=C(Cl)C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])OC([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C3[H])C([H])([H])C([H])([H])N2N=C1C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=NN2S(=O)(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(OC(F)(F)C([H])(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C(OC2=NC([H])=C([H])C([H])=C2C2=NC([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])OC1=C(OC([H])([H])C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])\C([H])=C([H])\C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=NC(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=[N+]([H])[H])C1=C(F)C([H])=C2N([H])C(=NC2=C1[H])C1=C([O-])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])\C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C2OC([H])=C3[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1OC1=C(C2=O)C(O[H])=C(OC([H])([H])[H])C(O[H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(=C(N1[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(C#N)C([H])=C([H])C([H])=C1[H] [H]O[C@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(OC([H])([H])[H])=C(C(=O)N([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C(F)C([H])=C2C([H])([H])[H])C2=C1[C@]1(C(O2)=C([H])C(O[H])=C(C(=O)C([H])([H])[H])C1=O)C([H])([H])[H] [H]OC1=NC2=C(N=C([H])N=C2N([H])[H])N1[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[H] [H]OC1=NC2=C(C([H])=C(Cl)C(Cl)=C2[H])N2C([H])=C([H])N=C12 [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(O[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C(=S)N(C(=S)C([H])([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C(S1)N1C(=NC([H])=C1C([H])([H])[H])C(=N2)N([H])C([H])([H])[H] COC1=CC(=CC(OC)=C1OC)C(CC(=O)C1=CC=CC(C)=C1)NC1=CC=C(C=C1)N(O)=O [H]ON([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]N(C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1=O [H]OC1=C(C(=O)O[C@@](C([H])([H])C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])C(C#N)(C([H])([H])[H])C([H])([H])[H])(C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=NN2C(=N1)N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(C([H])=C([H])N2C2=NC3=C(C#N)C([H])=NN3C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] CC1=CC(NC2=NC(NCCC3=CN=CC=C3)=NC=C2Br)=NN1 [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC2([H])C([H])([H])C([H])([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])=C2C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C2C(=O)C([H])=C(SC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] CC(C)C[C@H](NC(=O)NC1=C(Cl)C=CC=C1)C(=O)NO [H]C#C[C@@]1([H])N=C(N([H])[H])C2=C(SC([H])=C2[H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C(C([H])=C([H])C([H])=C3N=C12)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1Br)C([H])([H])[H])C([H])([H])C2([H])[H] [H]N1N=C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C1C(=O)N(C2=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(I)C([H])=C([H])C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C(=NC2=C([H])C([H])=C(Br)C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])[H])N1N=NC(=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)C([H])([H])C1=C([H])C(F)=C([H])C2=C1OC([H])([H])OC2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(C([O-])=O)=C1C([H])([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3=NC4=C([H])C([H])=C([H])C([H])=C4S3)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O\N=C(\C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])=C1[H])C([H])([H])[H] [H]OC1=C(C(=C([H])C([H])=C1N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]N(C1=NC2=C(C([H])=N1)N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)O[C@]2([H])C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@@]2([H])N([H])C(=O)C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])[P@@](=O)(O[C@@]([H])(OC(=O)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C2=NN(C(=O)C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C(S1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(=C([H])S1)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1 [H]N(C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2O[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C3=C(N=C(N=C3N=C2C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])[H])N([H])[H])C([H])=C1[H])C(=O)O[H] [H]N(C1=C2N([H])N=C(C2=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SC([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC(=O)C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NC([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C2=C(C([H])=C([H])C(\C([H])=C(/[H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)=C2[H])N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] CC(C)(C)C1=CC=C(CC(=O)N2CCC3(CC2)CCN(CNC(=O)C2=CC=CO2)C2=C(O3)C=CC=C2)C=C1 [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]O[C@@]([H])(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C(C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C3=C(N=C([H])N3C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C12 [H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C1([H])[H])C([H])([H])OC(=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C(OC([H])([H])C([H])([H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])SC(=N1)C([H])([H])[S@](=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]SC([H])([H])[C@]([H])(N([H])[H])C([H])([H])N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2SC2=C1C([H])=C([H])C([H])=C2[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(N2C([H])=NC([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1([H])[C@@]([H])(SC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1N=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C2=C(N=C([H])N=C12)N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C#C\C([H])=C(/[H])C2=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3S2)C([H])([H])C1([H])[H] [H]N1C(=O)C(=O)C2=C1C(=C([H])C([H])=C2Cl)C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=C(C(=C1C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] [H]C1=NC2=C(N=C(C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F)C#N [H]C1=NC(O[C@]2([H])C([H])([H])[C@]3([H])N([C@@]([H])(C([H])([H])C3=O)C2([H])[H])S(=O)(=O)C2([H])C([H])([H])C2([H])[H])=C(C(OC2=C([H])C([H])=C([H])N=C2C([H])([H])[H])=N1)C([H])([H])[H] [H]OC(=O)[C@]1([H])[C@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=C2[H])N2C([H])([H])C([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H][C@@]12C[C@]1([H])[C@H]([C@H](O)[C@@H]2O)N1C=NC2=C1N=C(N=C2NCC1=CC=CC(Cl)=C1)C#CC1=CC=C(F)C(F)=C1 [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C([H])([H])\C(=N/OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=C(C2=NC([H])=C([H])S2)\C(=C(/[H])C2=C([H])N(C3=C2C(OC([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2F)=C([H])C([H])=C3[H])C([H])([H])[H])C1=O [H]OC1=C([H])C(=NC2=C1C([H])=C([H])C(OC([H])([H])[H])=N2)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C2=C([H])C([H])=C(C([H])=C2N(C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C1=NN(N=N1)C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C(F)(F)F [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@@]2([H])C(=O)C3=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C(N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C(=O)C1=O)C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]O\N=C1/C2=C([H])C([H])=C(C([H])=C2C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C#N)N1C([H])([H])[H] [H]N([H])C1=NC([H])=C(S1)C#CC1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@]([H])(S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)[C@@]1([H])[C@]2([H])C([H])=C([H])[C@@]([H])(C2([H])[H])[C@@]1([H])N([H])C1=NC(=NC([H])=C1Cl)N([H])C1=C(OC([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C([H])([H])N1C([H])=C(C(=O)[C@@]2([H])N([H])[C@]([H])(SC2([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] CCCN(CCN1CCN(CC1)C1=CC=C(C=C1)C1=CC=CC=C1)C1CCC2=C(O)C=CC=C2C1 [H]O[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C1([H])[H])C([H])([H])[C@@](C3([H])[H])(C2([H])[H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])C#N)C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2S[C@@]([H])(C([H])([H])C([H])([H])[H])[C@]([H])(OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])(C1=C2C([H])=C([H])C([H])=C1[H])C1=C([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)[C@](OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)C(=O)N2C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C2N=C(C([H])=NC2=C1[H])N1C([H])([H])C([H])([H])C2(C(=O)N(C([H])([H])C3=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1N=C([H])C([H])=C1C1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@]2([H])C1=NC([H])=C([H])N1[H] [H]N(C(=S)N([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(Cl)(Cl)Cl)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C(OC(=O)N2C([H])([H])[C@]([H])(SC(=O)C([H])([H])[H])C([H])([H])[C@@]2([H])C([H])([H])OC([H])([H])C2=C(F)C([H])=C(F)C(F)=C2[H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])C([H])=C1[H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N1C(=O)[C@](N([H])[H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]1([H])C2=C([H])C(=O)C(SC([H])([H])[H])=C([H])C([H])=C2C2=C(C([H])=C(OC(=O)OC([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C(=N1)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N([H])[H])C([H])=C(C([H])=C1[H])[C@]([H])(C([H])([H])C(=O)N1C(=O)[C@@]([H])(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C(=O)C1=NN=C(O1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C1=NC2=C([H])C([H])=C([H])N=C2N1C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=N\N=C(/[H])C([H])([H])C([H])([H])OC1=C([H])C(OS(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H] [H]N(C(N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C(C#N)C#N)C1=C([H])C([H])=C([H])C2=C1N([H])C([H])=C2Cl [H]OC1=C([H])C2=C(OC(=O)C3=C2C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2N3[H])C([H])=C1[H] [H]N(\N=C(/[H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])S1 [H]C1=NN(C([H])=C1N1C([H])=C([H])C2=C(N(N=N2)[C@]([H])(C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])[H])C1=O)C([H])([H])[H] [H]N(C1=NC2=C(SC([H])=C2[H])C(=N1)C(=O)C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC(=NC(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@]([H])(C(=O)N([H])[C@@]1([H])[C@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]12[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(N2C(=O)C(=C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C2([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C(OC([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=NC([H])=C([H])C2=C1N([H])C1=C2C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]([H])(N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3SC3=C2C([H])=C(Cl)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])N(C3=NC([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] CON(C)C(=O)C1C2CCC(CC1C1=CC=C(F)C=C1)N2CCC[N+]12CCS[Re]11(=O)SCCN1C(=O)C2 [H]N(C(=O)C1=NN(C(=C1C([H])([H])C#N)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])N=C1Cl [H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(N([H])[H])=[N+]([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])C2([H])[H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C(=O)N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(N2C(=N1)N(C(=O)[C@@]2(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C(F)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N2N=C(N=C12)C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C2C(=O)C(=C([H])OC2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1N([H])C([H])=C2[H])C1=C([H])C(Cl)=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H] [H]N(C(=O)C1=NC(=C([H])C([H])=C1N([H])C1=C([H])N=C([H])N=C1[H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] CCOC(=O)C1=C(COC)N2N=C(C=C(C2=C1C(=O)OCC)C1=CC=CC=C1)N1CCOCC1 [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C([H])=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(F)C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN([H])C2=C1C([H])([H])N(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=NC2=C1OC([H])=C2[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])[C@@]([H])(N(C1=C2[H])C([H])([H])C(F)(F)F)C([H])(F)F)C(F)(F)F [H]N(N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(C(=O)C([H])([H])C([H])([H])[H])=C2OC1=O O=C(CCN1CCC2=C3C1CNC(=O)C3=CC=C2)NCC(=O)N1CCN(CC1)C1=NC=CC=C1 [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])(C([H])([H])C(=O)OC([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2(O[H])[C@]3([H])N(C([H])([H])C4([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(C([H])=C([H])C(O[H])=C4O[C@@]12[H])C3([H])[H] [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([C@]1([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C(C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C1[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)S1 [H]C#CC([H])([H])N([H])C1=NC(=NC(=N1)C([H])([H])[H])N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=NN([H])C([H])=C1[H] [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2N(C)C(=O)CC[C@]12C [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C(=O)C2=C3N(C([H])=C2[H])[C@@]([H])(SC3([H])[H])C2=C([H])C([H])=C([H])N=C2[H])C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])N=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC(=O)C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [C-]#[O+].[C-]#[O+].[C-]#[O+].NOOSC1=CC=C(NC(=S)NCCCCCCCC[N]23CC4=CC=CC=[N]4[Re+]2[N]2=C(C3)C=CC=C2)C=C1 [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C([H])=N1 [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C2=C(C([H])=C1[H])C1=NC3=C([H])C([H])=C(F)C([H])=C3C(C([O-])=O)=C1C([H])([H])C2([H])[H])C(F)(F)F [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C(OC([H])([H])[H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C(Cl)C([H])=C([H])C(Cl)=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])OC2=C(C(Cl)=C([H])C([H])=C2[H])C1=O)[C@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C([H])C3=C([H])C([H])=C(N=C23)C2=NN=C3C([H])=C(Cl)C([H])=C([H])N23)[C@]([H])(F)C1([H])[H] [H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C(C(Cl)=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[N+]([O-])=O O[C@H](COC1=CC=C(Cl)C=C1)CN1CCN(CC2=CC=C(Cl)C=C2)CC1 [H]O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C2=C([H])C(=O)C([H])([H])C([H])([H])[C@@]2(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NN2C([H])=NC3=C(SC(=S)N3C3=C([H])C([H])=C([H])C([H])=C3[H])C2=N1 [H]N(\N=C(/[H])C1=C([H])C(Br)=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=S)N([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC(=O)C1=C([H])C([H])=C(S1)[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C([H])C(C#C[C@@]3([H])N(C(=O)[C@@]([H])(C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C3([H])[H])C([H])([H])[H])=C2[H])N1C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)N(C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])S1)C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H] [H]\C(=C1\C(=O)ON=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H] [H]OP(=O)(O[H])OC([H])([H])[C@@]1([H])O[C@]([H])(N2C([H])=NC3=C(N=C(SC([H])([H])C([H])=C([H])[H])N=C23)N([H])C([H])([H])[H])C([H])([H])[C@]1([H])OP(=O)(O[H])O[H] [H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])N(C2=C1C([H])=C(Br)C([H])=C2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N(\N=C1/C(=O)N([H])C2=C1C(Br)=C([H])C(=C2[H])C(=O)N([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C([H])([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(N(C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])N=C3C(=N2)C2=C([H])C([H])=C([H])C(OC(F)(F)F)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]4([H])N(C(=O)[C@@]5([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])SSC3([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])O[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])C4([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=O)[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]C1=NN(C2=C1C(=NC([H])=N2)N1C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C4=C(C([H])=C([H])N4[H])C([H])=C3[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])N1N=C(C(=O)N([H])C1=O)C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C(=O)N([H])C1=NC([H])=C(S1)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C(S1)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])S1 [H]N(C1=NN2C(=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])=N1)C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]ON([H])C(=O)C1(C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C(=NC4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(C([H])=C1C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C(=NC3=C([H])C([H])=C(Cl)C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])C#N)(C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C2=C(C3=C([H])C([H])=C(F)C([H])=C3C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C1([H])[H] [H]C1=NN(C2=C([H])C([H])=C([H])C(=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])N=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(C([H])=C2[H])C(=O)N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C(SC([H])([H])[H])=C1C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])C(=S)N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(C2=C(C([H])=C([H])C(=N2)C([H])([H])C([H])([H])C([H])=C([H])[H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])[C@]1([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])([H])N(C2=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N2C(=O)S\C(=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2=S)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@]1([H])C(=O)C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C(C#N)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(C#N)=C([H])C([H])=C1C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])SC2=C([H])C(O[H])=C([H])C(=C2O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NN(C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC3=C([H])C([H])=C([H])C(Cl)=C3[H])=C([H])C([H])=C12 [H]C1=NC(=NC(=C1[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C2N=C([H])C([H])=C([H])C2=C(C(=C1[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H])[N+]([O-])=O [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])O[H])C([H])([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=C(C(=C1C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]\C(=N/N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(Br)=C1[H])C([H])([H])[H])C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H] [H]N([H])C1=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C([H])C([H])=C3[N+]([O-])=O)=C2C([H])=N1 [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(\C([H])=C2/N([H])C(=O)\C(N([H])C2=O)=C(/[H])C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])S3)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N=C([H])N=C2O1)N1C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=C([H])S2)C1=S)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(O1)C(\[H])=C(/[H])C(=O)C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C2=C(N([H])[H])C([H])=C([H])C(=C2[H])C(F)(F)F)C1([H])[H] [H]OC(=O)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])=C(C2=C([H])C([H])=C([H])C([H])=C2Cl)C2=C([H])C([H])=C([H])C([H])=C2Cl)C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])N1C(=C(C(=C1C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C(=C([H])C(O[H])=C1OC([H])([H])[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C2N([H])C([H])([H])[C@]3([H])N(C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C(F)C([H])=C(F)C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])O1)C(=O)N(C1=C([H])N=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C(=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C(\[H])=C(/[H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]N([H])C(=O)C1=C([H])N=C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]OC([H])([H])[C@@]1([H])OC(=O)\C(=C(/N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=O [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=NC(O[H])=C(N=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C(O[H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]S\C(=N/C([H])([H])C1=C([H])C([H])=C(N([H])C([H])([H])C(=O)OC([H])([H])[H])C(F)=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC1=NC([H])=C(C([H])=N1)C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=NC(OC3=C(C4=C([H])C([H])=C(C([H])=C4[H])S(=O)(=O)C([H])([H])[H])C(OC3=O)(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=C(F)C([H])=C(F)C([H])=C1C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]O[C@@]12C([H])([H])[C@]3(C(=O)[C@]4([H])OC5=C(OC([H])([H])[H])C([H])=C([H])C6=C5[C@@]14C([H])([H])C([H])([H])N(C([H])([H])C(=C([H])[H])C([H])([H])[H])[C@@]2([H])C6([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C3([H])[H] [H]C1=C(C(=O)O[C@@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C2N1C([H])([H])C([H])([H])N(C2=O)C([H])([H])C([H])(F)F)C([H])([H])[H] [H]OC(=O)[C@@](OC1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(C2=C([H])N([H])C3=C(N([H])[H])C([H])=C([H])C([H])=C23)=C(I)C([H])=N1 [H]C1=C(OC(=O)C([H])([H])[H])C(OC(=O)C([H])([H])[H])=C([H])C(=C1[H])C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2OC([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC(=O)C1=C(N([H])C2=C([H])C([H])=NC(=N2)N([H])C2=C([H])C([H])=C([H])C([H])=C2ON([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(C2=NN(C3=C2N=C(C([H])=C3N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F [H]C1=C([H])C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C1=C(C([H])=C(OC([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])[C@]([H])(O[H])[C@]2(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])C([H])([H])[C@]2([H])[C@]1([H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C([H])([H])[H] [H]N1C(=NC2=C3C([H])=C([H])C(Br)=C([H])C3=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=C12)C1=C(F)C([H])=C([H])C([H])=C1Cl [H]O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)O[H] [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(F)C(F)=C(F)C(F)=C1F)C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])[C@@]1([H])N(C2=NC3=C(N([H])C([H])([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@](O[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=NC2=C1N=C(SC1=C([H])C3=C(OC([H])([H])O3)C([H])=C1Br)N2C([H])([H])C([H])([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N1N=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C(SC2=C([H])C3=C(OC([H])([H])O3)C([H])=C2Br)=NC2=C1N=C([H])N=C2N([H])[H] [H]N([H])C1=NC([H])=C([H])C2=C1C(=C([H])S2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C2N([H])N=C(C2=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] CCOC(=O)C1=C(CC=C)N2N=C(C=C(C2=C1C(=O)OCC)C1=CC=CC=C1)N1CCOCC1 [H]OC1=C(O[H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C1C2=C([H])C(=C3[H])C([H])([H])[H] [H]N(C1=NC(=NC2=C1N=NN2C1=C([H])C([H])=C(C([H])=C1Br)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=N[C@]2([H])[C@]([H])(Cl)[C@]2([H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C1=C(C(=C([H])C([H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C([H])=C3[H])C(=O)N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=S)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C2=C(N3[H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=NC([H])=C([H])C([H])=N1 [H]N([H])C1=NC(=O)\C(N1[H])=C1\C2=C(N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C1([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=NSC(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)C([H])([H])[C@]1([H])N(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]23[H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)N([H])[C@]2(N(C(=O)N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])[H])C1=O [H]O[C@]1([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[C@@]1([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1/C(=C([H])\C1=C(N([H])C3=C([H])C([H])=C([H])C([H])=C13)/C(=C\2/[H])/C(=O)OC([H])([H])[H])/C(=O)OC([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])C1=C([H])C(C([H])=C(C#N)C#N)=C([H])C(OC([H])([H])[H])=C1O[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N1C([H])([H])[C@]([H])(F)C([H])([H])[C@@]1([H])C1=NC2=C(OC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(=O)N1[H] C[C@@]1(O)C[C@@H](C1)C1=NC(=C2N1C=CN=C2N)C1=CC(=C(C=C1)C(=O)C1=CC=CC=C1)N(O)=O [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C(C(=O)C1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])SC(C#N)=C1[H] [H]OC1=C([H])C(Cl)=C(C([H])=C1[H])[C@]1([H])OC([H])([H])[C@]2(C([H])([H])O[H])C([H])([H])C([H])=C(C([H])([H])[H])[C@@]1([H])C2([H])[H] [H]N(C(=O)N([H])C(C1=C([H])C(=C([H])C([H])=C1[H])C(N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=O)OC(=NC2=C1[H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1[C@]2([H])C([H])=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(F)=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(C(=O)N4C([H])([H])C([H])([H])SC([H])([H])C4([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]2([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NN(\C(S1)=N\C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=NC([H])=N1 Cl.COC1=C(OC)C=C2C(=O)[C@@H](CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1 [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C#CC([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(=O)C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C11C2=C([H])C([H])=C(C([H])=C2OC2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C(Br)C([H])=C2C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[C@@]2([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C2=C(ON=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C(Cl)C([H])=C([H])S3)C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@@]1([H])N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(Br)C([H])=C2C(=N[C@]([H])(OC([H])([H])C([H])([H])[H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(N=C(N2C([H])([H])C([H])([H])C([H])([H])O[C@@]2([H])O[C@]([H])(C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=N1 [H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C([H])([H])[C@]([H])(N3C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C3([H])[H])[C@@]([H])(C([H])([H])[H])C2([H])[H])C(Cl)=C1[H])C([H])([H])[H] [H]OC1=NC(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(N([H])C3=NN4C([H])=C([H])C([H])=C(C4=N3)C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C([H])C([H])=C(Cl)C([H])=C12)C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O C[C@@H](NC(=O)NCCC(C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NO1)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(C(=O)N1C([H])([H])[H])C1=C([H])C(F)=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C11C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2F)C([H])([H])C2=C([H])N([H])C(=O)C3=C([H])C(Cl)=C(Cl)N23)C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C(S1)C1=C([H])N=C([H])N=C1[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C2C(=C([H])S1)C(=NN(C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C(C2=C([H])C(F)=C([H])C([H])=C2N1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1([H])C([H])([H])N(C([H])([H])C2=C([H])C(F)=C(C([H])=C2[H])C2=NC3=C([H])C([H])=C(N=C3S2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] COC1=C(F)C(=NC(=N1)N1C[C@H]2C(=O)N(C)C(=N)N[C@]2(C1)C1=CC=C(F)C=C1F)C1CC1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2OC1=O [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])O[H])C(=O)O[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] NS(=O)(=O)C1=C(F)C(F)=C(NC23CC4CC(CC(C4)C2)C3)C(F)=C1F [H]C1=NC([H])=C([H])C(=C1[H])[C@]1([H])OC2=C(N=NC(SC([H])([H])C([H])([H])C([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C(C2=C(N1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])N(C2=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1O[C@]1([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=NC2=C(C([H])=C([H])C([H])=C2Br)C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C([H])C(=C1[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]N([H])C(=O)C1=NC(=NO1)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]2([H])N(C([H])([H])C3=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])OC([H])([H])[H] [H]C1=NN(C(=C1[H])C1=C([H])C2=C(N=C([H])N(C2=O)C([H])([H])[H])C([H])=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])N=C(O1)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)C(N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C2=C(OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C#CC2=C(C([H])=C([H])S2)C([H])([H])[H])C([H])=C1[H] ClC1=CC=C(C=C1)C1=CSC(NC(=O)CCCCN2CCCCC2)=N1 [H]OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C(I)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] COC1=CC(=CC=C1OCCN1CCCC1)N1CC2=CC=C(CC3=CC(F)=CC=C3)N=C2C1=O [H]N(C(=O)[C@]([H])(C([H])([H])[H])[C@@]1([H])C([H])([H])C2=C(C(OC([H])([H])[H])=C([H])C(=C2C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 COC1=CC=C(C=C1)C1=NN(C(C1)C1=CC2=CC=CC=C2C=C1)C1=CC=CC=C1 [H]O[C@]1([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C(=O)N(C(=N2)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C2N=C([H])N3[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C1=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C2=C(C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])C2(C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N([H])C(=NC(=O)C1=C(N([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])N([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C(Cl)C([H])=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]OC(=O)[C@]1([H])N([H])C2=C([H])C(Br)=C(OC3=C([H])C(=C(O[H])C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(Br)=C2C1([H])[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]2([H])N1C2=C(N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C(F)(F)F)C(F)(F)F [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]1([H])C(=O)C(=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=CN=CC=C1[C@@H]1CC[C@@H](CC1)N1CC(C1)NC(=O)CNC1=NC=NC2=CC=C(C=C12)C(F)(F)F [H]C1=C([H])C([H])=C(O1)C([H])([H])N(C1=NC([H])=NC2=C([H])C([H])=C(C([H])=C12)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(SC(=C2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])OC2=C(I)C([H])=C([H])C([H])=C2[H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C(Br)C([H])=C2[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1N(C(=O)C2=C(N(C(=O)C([H])=C12)C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C(=O)C1=C(N([H])C(=O)C2=NC3=C(S2)C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)S1 [H]N(C(=O)C([H])([H])OC1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C([H])C([H])=N1)C1=NC([H])=C([H])S1 [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])N1C(=O)S\C(=C(/[H])C2=C([H])OC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])([H])[H])C1=O [H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]C1=NN(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3N([H])C(=O)C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H] [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=NC(=O)C([H])([H])S2)[C@]([H])(C2=C([H])C([H])=C(Br)C([H])=C2[H])C1([H])[H] [H]C1=C([H])C2=C(N=C(N2C([H])([H])C([H])([H])C([H])([H])O[C@@]2([H])O[C@]([H])(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])=N1 [H]C1=C(C2=C([H])C([H])=C([H])N=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C(=C([H])C1=O)S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC1=C([H])C([H])=C(Cl)C(=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N1N=C(N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]O[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]4([H])C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C(=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C(=NC([H])=N1)N(C(=O)C21C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C([H])([H])C#CC1=C([H])C2=C(C([H])=C1[H])N1C(=NN=C1[C@@]([H])(N=C2C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]1(C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]3([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]1([H])[C@@]([H])(C([H])([H])C([H])([H])OC([H])([H])[H])C3([H])[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)[C@]1(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])N(C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC(=NN2C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] CCN1CCC(CC1)NC1=CC2=C(NC(=O)C2=C(C2=NC3=CC=CC=C3N2)C2=CC=C(OC)C=C2)C=C1 [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C1C([H])([H])N([H])C2=O [H]N(C(=O)C([H])([H])C([H])([H])[H])[C@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(N([H])C2=NC(=NC([H])=N2)N2C([H])([H])C([H])([H])C([H])(OC3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H] COC(C)(C)C1=CC(=CN=C1)C1=CC2=C(C=C1)N1C(C)=NN=C1CC2 [H]C1=C(N=C(SC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N1C(=O)S\C(=C(\[H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C(F)(F)F)C([H])=C([H])C(Br)=C2[H])C1=O [H]O[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(OC([H])([H])[C@]4([H])OC4([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C1=NC(=NO1)C1=NN([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=C(C2=C(C3=C([H])C(OC([H])([H])[H])=C([H])C(=C3N=C12)C([H])([H])[H])C([H])([H])N1C([H])([H])[C@@]([H])(O[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=NO2)C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])N1N=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(SC1=C(Cl)C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N(C1=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C(Br)O1)C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]OC1=C2N=C([H])N(C2=NC(=N1)N([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1([H])C(F)(F)P(=O)(O[H])O[H] [H]N(C(=O)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\C([H])=C1\S\C(N(C1=O)C([H])([H])C([H])([H])[H])=C(\C#N)C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])[H] [H]O[C@@]12C([H])([H])C(=C([H])[H])[C@@]3([H])O[C@@]3(C(=O)OC([H])([H])[H])[C@]1(C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]1(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]3([H])C([H])=C([H])C(=O)OC([H])([H])[C@]3([C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]12[H] [H]OC1=C([H])C([H])=C2O[C@@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])O4)C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2C(=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(\N=C(/[H])C2=C([H])OC3=C([H])C([H])=C(C([H])=C3C2=O)C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(SC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C(F)=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NC(C2=C([H])C([H])=C([H])C(=C2[H])[N+]([O-])=O)=C2N=C([H])C([H])=C([H])C2=C1[H] [H]OC([H])([H])C#CC([H])([H])OC1=NC(=NC(N([H])S(=O)(=O)C2=NC([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1OC1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C1C(=O)N(C([H])=C2[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C([H])N1C([H])=C(C(=O)N([H])[C@@]2([H])[C@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(C3([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C(=O)C2=C([H])C([H])=C(F)C([H])=C12 [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C2N([H])C(=O)C(C3=NC([H])=C([H])S3)=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=S)N1N=C(C(=C1[H])C1=C([H])N2N=C([H])N=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C3=C([H])C([H])=C([H])C([H])=C3[S@@](=O)C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@](C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=C(N2C([H])=C(Cl)C([H])=C(Cl)C2=N1)C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])[C@]1([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=NC([H])=C2C([H])([H])C(=O)C2=C([H])C([H])=C(F)C(=N2)C2=C(F)C(F)=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C(=O)S\C(=C(\[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])C1=C(OC([H])([H])C(=O)N2C([H])([H])[C@@]([H])(N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Cl)=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])ON=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C2([H])[H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(C(=O)N(C2=C([H])C(OC([H])([H])[H])=C(C([H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(SC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=NC2=C1[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C(C1=C([H])N2C(=N1)N(C(=C(C2=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C2C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C3[H])C([H])([H])[H])C1=O [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C(=O)OC([H])([H])C([H])([H])[H] CN1N=C(CC(=O)NC2=CC=C(OC(F)(F)F)C=C2)C2=CC=CC=C2C1=O [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])C(=N1)C([H])([H])SC1=NC(=C(O1)C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([H])([H])OC([H])([H])C([H])([H])F [H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=C([H])C(C#N)=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]O[P@](=O)(C([H])([H])[C@@]([H])(C(=O)N(N([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])N2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])SC1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC#C[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=[N+]([O-])C(C2=C([H])C([H])=C(F)C([H])=C2[H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=N[H])N([H])[H])C([H])([H])C1([H])[H] [H]O\C(OC([H])([H])C([H])([H])[H])=C(\SC1=C([H])C([H])=C([H])C([H])=C1[H])/C(/[H])=C(/[H])C(=O)C(=O)OC([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=NC(=C([H])C([H])=C3C2=O)C([H])([H])[H])C(=O)OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N=C([H])C([H])=C1[H])[S@](=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])C([H])([H])O2)C1=NN=C(O1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])OC1=C(C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N([H])C1=NC2=C(N=NN2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2F)C(=N1)C1=NC([H])=C([H])S1 [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=O)N2C([H])([H])C#N)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SN=N1)C([H])([H])C1=C([H])C(F)=C(C([H])=C1[H])C(F)(F)S(=O)(=O)N([H])[H] [H]ON(C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=C([H])C(=C1[H])C(=O)OC([H])([H])[H])C1=C([H])C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])=C(OC([H])(F)F)C([H])=C1[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C(=O)[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)\N=C(/N([H])C([H])([H])[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H] [H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(C1=NN([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C(F)C([H])=NC(=N1)N([H])[C@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C1=NC([H])=C(F)C([H])=N1)C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]C1=C([H])C([H])=C(S1)C1=NC(=NO1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N(N(C#N)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H] [H]N([H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1Cl)C(=O)N([H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC1=NC(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C2=C([H])C(F)=C([H])C([H])=C2[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]N([H])C1=C(C([H])=NC2=C([H])C([H])=NN12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=C([H])C(=O)C2=C(O[H])C(O[H])=C(O[H])C(OC([H])([H])[H])=C2O1 [H]N(C(=O)C1=NC([H])=C([H])N=C1[H])C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(S3)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C4=C(C([H])=C([H])C([H])=C4O[C@@]12[H])C3([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C([H])C(=NN12)C1=C([H])N=C([H])N1[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@]2([H])OC(=O)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/OC([H])([H])[H])C(=O)O[C@@]2([H])[C@@]([H])(O[C@]([H])(C([H])([H])SC([H])([H])[H])[C@@]2([H])OC(=O)C(\[H])=C(/[H])C2=C([H])N([H])C([H])=N2)N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C3=NOC(=N3)C3=C([H])C([H])=C([H])O3)C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])N=C([H])C(=C1[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]OC1=C([H])C(O[H])=C2C([H])=C(SC2=C1[H])C1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C(=C([H])C([H])=C1[H])C1=NN([H])N=N1)=C1/C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])SC([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C2C(=O)C(=O)C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C#CC([H])([H])N([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]O[C@@]1(C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])[C@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C(Br)C([H])=C2[H] [H]N(C(=O)C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])S(=O)(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H] [H]N([H])C1=C(C(=NC(=N1)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C(Cl)C(Cl)=C2C1=O [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C1=NN=NN1C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=NN=C(S2)C2=C([H])N=C(S2)C2=C([H])C([H])=NC([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)[S@](=O)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C(=O)N(C([H])([H])C(F)(F)F)C([H])([H])[C@]([H])(C2=C(F)C(F)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] COC1=CC([C@@H]2C[C@H]2NC(C)=O)=C(OC)C=C1 [H]N(C(=O)OC1=C([H])C(N([H])C(=O)OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C([H])N=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])S[S@](=O)C([H])([H])C([H])=C([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1 [H]N(C(=O)C1=C([H])C(\C([H])=C(/[H])N2C([H])=NC3=C([H])N=C([H])N=C23)=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3OC(=O)N(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(O2)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H] CC(=O)N[C@@H](CC1=CC(F)=CC(F)=C1)[C@H](O)CNC1(CCCCC1)C1=CN(N=N1)C12CC3CC(CC(C3)C1)C2 [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(O[C@]([H])(N2C(=O)C([H])([H])[H])C2=C(Cl)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])N=C(SC([H])([H])C([H])([H])C([H])([H])[H])N=N1 [H]N1C(=O)S[C@]([H])(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(C([H])=C(C([H])=C2[H])C2=NOC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])[H])=C1[H] [H]C1=C([H])C(F)=C(C(Cl)=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(C(=O)C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]OC1=C2N=NN(C2=NC(=N1)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])P(=O)(O[H])O[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(I)N(C2=C1C([H])=C(OC([H])([H])[H])C(=C2[H])[N+]([O-])=O)C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(C([H])=C([H])C(C3=C([H])C(C#N)=C([H])C([H])=C3[H])=C2OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=C1[H] [H]N([H])C1=NC([H])=C([H])N2C([H])=NC(=C12)C1=C(C2=NC(=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])[C@]([H])(N2C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N=C1[H])C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])OC5=C([H])C([H])=C6N=C(SC6=C5[H])S(=O)(=O)N([H])[H])[C@@]4(C([H])([H])[H])[C@@]([H])(O[H])C([H])([H])[C@]23[H])C1([H])[H] O=C1C2CCN(CC2)\C1=C/C1=CN(CC2=CC=C(C=C2)C#N)C2=CC=CC=C12 [H]N1C([H])=NC2=C1C(=O)N(C(=O)N2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])[C@]([H])(O[H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2OC1=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] COCCC1=CC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CN=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)=C1 [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(OC2=C([H])C([H])=C([H])C(Cl)=C2C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=NN2C2=C([H])C([H])=C([H])C([H])=C2[H])C(=N1)C1=C([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C1=C(N([H])[C@]2([H])C3=C(OC([H])=C3C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C(=C([H])C([H])=C2N=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(OC([H])([H])[C@@]([H])(N3C([H])([H])C([H])([H])C(O[H])(C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])([H])C3([H])[H])C2([H])[H])=C1[H] CN1C(=O)C(NC2=NC=C(F)C=C2)=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12 [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])N=C3N2C([H])=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C2N([H])C(=O)C([H])([H])OC2=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])=C1[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C(C(=NN1C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CCCC1=C(C2=NC(C)=NO2)C(C(=O)OCC)=C2N1N=C(C=C2C1=CC=CC=C1)N1CCOCC1 [H]O\C(OC([H])([H])C([H])([H])O[H])=C1\C(=NC(=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C(C(=O)OC([H])([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C#CC([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=N2 [H]N(C(=O)C1=C(C([H])=C(S1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=NC([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(C#CC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C(=O)C1=C3C([H])=C([H])C([H])=C([H])C3=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(C([H])=C([H])C(Cl)=N1)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C2([H])[H])C1([H])[H] [H]N(\N=C(/[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] NC1=NC2=C(C=NN2CC(O)=O)C2=NC(=NN12)C1=CC=CO1 [H]\C(=C(\[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC(=NC2=C(C#N)C([H])=NN12)N1C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C(=NC([H])=N1)N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=NN2C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]ON([H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])N1C(=NC(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])[C@]1([H])C(=O)N(C(=O)C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C2([H])[H] NC(N)=NCCC[C@@H](NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(=O)NCC1=CC=C(O)C=C1 [H]N(C1=NOC2=C(C3=C([H])C4=C(C([H])=C3[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=NN=C4[H])C(=C([H])C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C([H])([H])C(OC(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C1[H])C([H])([H])C2([H])[H] NS(=O)(=O)C1=CC=C(C[N+]2=CC3=COC4=CC=CC=C4C3O[Zn]22(Cl)(Cl)OC3C(=COC4=C3C=CC=C4)C=[N+]2CC2=CC=C(C=C2)S(N)(=O)=O)C=C1 [H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])=C(O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])N(C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N(C([H])=N1)C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C2N(N=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])=C([H])C([H])=C2F CC1=CC(=CC(=O)N1[C@@H](CC1CCCCO1)C(=O)NC1=NC=C(Cl)S1)S(=O)(=O)C1CCCC1 [H]C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(F)C([H])=C([H])C([H])=C2[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12F [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N1C([H])([H])C2=C(N(C3=C([H])C([H])=C(F)C([H])=C23)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C(C#N)=C(C2=C([H])C([H])=C([H])C([H])=C2Cl)C2=C1C1=C(OC2([H])[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C(=O)[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]O[C@@](C1=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])[C@@]1([H])C([H])([H])N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)[C@@]([H])(N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)C1=NC([H])=C([H])S1)N([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])[H] [H]OC1=C(C(=O)N([H])C2=C([H])N=C([H])C([H])=C2[H])C(=O)C2=C([H])C([H])=C([H])C3=C2N1C([H])([H])C3([H])[H] [H]N([C@@]([H])(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N(N1C([H])=NN=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[C@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C2=C(C(=NN2C([H])([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N(C(=O)C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@@]([H])(C1=NC2=C(N1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1N=C(C([H])=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)C1=NN=C(O1)S[C@]1([H])C(=O)N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(N=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NOC(=N1)C([H])([H])OC1=C(Br)C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N(C(=O)C(=O)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(ON=C1C([H])([H])[H])[C@]1([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C3C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4O[C@@]([H])(C4=C([H])C(OC([H])([H])OC([H])([H])[H])=C([H])C([H])=C4[H])C3=C2C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C1=C([H])C([H])=C2C(OC([H])=C(C3=C([H])N=C(C([H])=C3[H])N3C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C3([H])[H])C2=O)=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C(Cl)C([H])=C(\C([H])=C2/S\C(=N/C([H])([H])C([H])([H])C([H])([H])[H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C(N([H])C2=NC(=NC(=N2)N([H])[C@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(Cl)C([H])=C1N1C(=O)N([H])C2=C([H])C(=C([H])C([H])=C12)C([H])([H])N([H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C1[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])SC([H])=C1[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C(F)C([H])=C(C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C(N(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N1C2=C([H])C(=C([H])C([H])=C2C(SC2=C([H])C([H])=C(F)C([H])=C2F)=C1C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]O[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] COC1=C(NC2=NC=NC3=C2N=CN3C2O[C@H](CO)[C@@H](O)[C@H]2O)C=CC=C1 [H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(C2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@]([H])(C1=C(C([H])=C([H])C(=C1[H])C(F)(F)F)N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)[C@@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])O[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C2([H])C([H])([H])C2([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C1=C(Br)C(=O)C([H])([H])C([H])([H])[C@]1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C(O1)C(\[H])=C1/SC(=O)N([H])C1=O)C([H])([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(=O)N([H])C2=C([H])C([H])=C([H])C(N([H])C3=C([H])C4=C(C([H])=C3[H])\C(=C(/[H])C3=C([H])C([H])=C([H])N3[H])C(=O)N4[H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(SC(F)(F)F)C([H])=C3Cl)C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]\C(=C1/C2=C([H])C([H])=C([H])C([H])=C2C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] O=C(NC1=CC=CC(=C1)C1=CC=CN=C1)N(CCC(C1=CC=CC=C1)C1=CC=CC=C1)CCN1CCOCC1 [H]OC(=O)C([H])([H])C1=C(OC(=N1)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N(C2=O)C1=C(F)C(F)=NC(F)=C1F [H]N1C([H])=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])=NN=C1[H])C([H])([H])C(F)(F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C3C(C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)=C2[H])[C@@]1([H])C(=O)O[H] [H]OC(=O)C([H])([H])N([H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C([H])=C([H])C(Br)=C2[H])C([H])=N1 [H]N([H])C1=C([H])C2=NC([H])=NC([H])=C2C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(Cl)=C1C(=N2)C([H])([H])C([H])([H])C1([H])[H])C1=C(Cl)N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC2=C(N=C([H])N2[H])C(=N1)C1=C([H])C([H])=C([H])O1 [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1[H])[C@]1([H])N(C([H])([H])[H])[C@@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])[C@@]2(C(=O)OC([H])([H])[H])C(=O)[C@]1(C(=O)OC([H])([H])[H])C([H])([H])N(C([H])([H])[H])C2([H])[H]