[H]OC1=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NSC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C(Br)C([H])=C1[H] [H]N(C(=O)[C@]([H])(C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C([H])=C(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C([H])N=C2C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C1[H])C(C1=C([H])C([H])=C(F)C([H])=C1[H])=C(N(C2=O)C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])O[C@@](N3C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C3=C(C5=C(C([H])=C([H])C([H])=C5[H])N23)C2=C4C([H])([H])N([H])C2=O)(C([H])([H])[H])[C@]1([H])OC([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=NC2=C(O1)C([H])=C([H])C([H])=C2O[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)N([H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C3=C2C(O[H])=NC(=N3)C([H])([H])[H])C([H])=C1[H])C(=O)O[H] [H]N([H])C1=NC(=NN1C1=NC([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(Br)C([H])=C2O1 [H]C([H])=C([H])C([H])([H])N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])N1C(=O)C2=C([H])C(F)=C(F)C([H])=C2N=C1C([H])([H])[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C([H])([H])C(N2C([H])([H])C([H])([H])C([H])(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC(=C([H])N=C2N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]C1=C([H])C(=C([H])S1)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC1=O [H]N1C(=C([H])C2=C1C([H])([H])C([H])([H])N([H])C2=O)C1=C([H])C(=NC([H])=C1[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])([H])N1C([H])([H])C([H])([H])C2(N(C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])N(C2=O)C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] CC1=CC(=CC=C1)C(C1=CN=CC=C1)C1=CC2=C3N(CCC3=C1)C(=O)CC2 [H]N(C(=O)C1=NN(C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N([H])C1=NC2=C(OC3=C([H])C([H])=C([H])C(F)=C23)C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(C([H])=C23)C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H] FC1=CC(F)=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(=C2)C(=O)NCCCl)C=C1 FC1=CC=CC=C1C1=NC2=CNN=C2NC2=C1C=C(C=C2)C#N [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NC(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]([H])(O[C@@]([H])(O[C@]2([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])[C@@](OC([H])([H])[H])(C([H])([H])[H])C3([H])[H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2(OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]1([H])O[H])C([H])([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(SC([H])([H])C2=NOC(=C2[H])C([H])([H])[H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C2C3=C(SC(=N3)[N+]([H])([H])[H])C([H])([H])C2=C([H])C(=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])C3=NC(N([H])C4=C(C([H])=C([H])C([H])=C4[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(Cl)C([H])=N3)C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])C2([H])[H])C([H])([H])N([H])[C@]1([H])C(=O)N1C([H])([H])C([H])=C(C2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(Cl)=C(C([H])=C1[H])N1C(=O)C2=NC([H])=C([H])C([H])=C2C1=O [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])N2C(=S)N([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])([H])C1([H])[H] [H]C1=C(I)C([H])=C(Br)C(=C1[H])N(C1=NC(=C([H])C(=N1)C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C([H])N(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] COC1=C(OC)C=C(CC(OC(=O)\C=C\C2=CC=C(C=C2)C2=CC=CC=C2)C(=O)NO)C=C1 [H]O\C(OC([H])([H])[H])=C1\C(=NC(=C(C(=O)OC([H])([H])[H])[C@@]1([H])C1=C([H])C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]\C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1/C(=O)/C(=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H] [H]\C(=C1\OC([H])([H])OC1([H])[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C(C([H])=C1[H])C1=NC(=C2N=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]OP(=O)(O[H])OC([H])([H])[C@](N([H])[H])(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C2C([H])=C([H])C(=NN12)N([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C1=C([H])SC([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N CN([C@H]1CN(C[C@@H]1C1=CC=C(F)C=C1)C(=O)N1CCN(CC1)C(C)=O)C(=O)C(C)(C)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=NC([H])=C(O2)C2=C([H])C([H])=C([H])C([H])=N2)=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])OC(=O)N(C(=O)C([H])([H])[H])C([H])([H])C1=[N+](C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1Cl)[N+]([O-])=O)C(=O)C1=C([H])C([H])=C(Cl)C(=C1[H])[N+]([O-])=O [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC([H])=C(S1)N(C([H])([H])C1=C([H])C2=C(N=C(N([H])C2=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])O[H])C(=O)O[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C(=N\OC([H])([H])C([H])([H])[H])\C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C2=C(N=C(N=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=NC([H])=C([H])N2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C2O[C@]3(C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4(OC([H])([H])C([H])([H])[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=C([H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1OC1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=O [H]N(C1=C([H])C([H])=C2N=C([H])C(OC(F)(F)F)=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=NC(=NO1)C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C2ON=C(C2=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2N=C(N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(SC3=C2C2=C(N=C(Cl)C([H])=C2[H])C([H])=C3[H])C(=O)N([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1 [H]C1=C(OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=C(OC2=C(C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])N=C1C([H])([H])[H])C([H])([H])[H] COC1=C(OCCCC#N)C=CC(=C1)C1=NC2=CC=C3C=CC=CC3=C2C(=C1)C(O)=O [H]N([H])C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C1=C(N2[H])C2=C(C3=C4N2C([H])([H])C([H])([H])C([H])([H])C4=C([H])C([H])=C3[H])C2=C1C(=O)N([H])C2=O [H]N([H])C1=NC(=NN1C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])[H] [H]N1N=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C(=C([H])N=C12)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])N=C1[H] FC1=C2C(C=CC=C2N2CCN(CCCCOC3=CC=C4CNC(=O)C4=C3)CC2)=CC=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C#N)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])C1=NN=C(S1)C1=C(Cl)C([H])=C(OC([H])([H])[H])C([H])=C1Cl [H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C#CC1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C1=O)C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C3=C(O[H])N=C(N=C3N=C2[H])N([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]C1=C(C(=O)C([H])([H])[C@]2(O1)C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C(Br)=C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(F)C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]12[H] OC1=CC2=C(NC3=C2CCN(C3)C(=O)NC2=CC=CC(=C2)C2=CC=CC=C2)C=C1 [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC(C)(CC(O)(CC1=CC2=CC=NC=C2N1)C(F)(F)F)C1=CC(=CC=C1O)C1=CC=CN=C1 [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])N=C([H])C([H])=C2[H])=C1[H])C(=O)N([H])[H] CCC1=C(CCCC(O)=O)C=CC=C1C1=NSC(=N1)C1=CC=C(OC(C)C)C(=C1)C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C1=NN=C(O1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(Cl)C2=C(C(=C1O[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]C1=C(N=C2C(=C1[H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C1=NN(N=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])N=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H] Cc1cnc(NC[C@H]2CCCO2)nc1-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1 [H]N(C1=N\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C(=O)N1C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H][C@@]12C[C@]1([H])N([C@@H](C2)C#N)C(=O)[C@@H](N)C1CCN(CC1)C(=O)C1=CN=CC=N1 [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])[C@@]([H])(N2C3=C(C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] COC1=C(OC)C=C(C(Br)=C1)S(=O)(=O)NC1=CC(O[C@@H]2CCN(C)C2)=C(Cl)C=C1 CSCC[C@@H](CO)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1 [H]C([H])=C([H])C1=C(N=C(N1C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(\C([H])=C3/SC(=S)N(C3=O)C3=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(\[H])=C2/C(=O)N([H])C3=C([H])C([H])=C(C([H])=C23)S(=O)(=O)N([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(OC1=O)C([H])=C([H])C(=C2[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(N=C2N=C([H])C([H])=C([H])N12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C(C(=O)N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])C([H])([H])C2=C(Cl)C([H])=C([H])C(OC([H])([H])[H])=C2[H])N2N=NC(=C2[H])C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C1=C([H])N(N=C1[H])C1=C([H])C(C#N)=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)[C@]([H])(N(C(=O)[C@@]1([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(N=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(F)=C(C(=O)C2=C(N=C3C([H])=C([H])C(=C([H])N23)C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)N([H])[H])C(F)=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C3C(=NC([H])=C2[H])N([H])C([H])=C13)S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(C(=N/OC([H])([H])[H])\C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@](O[H])(C1([H])[H])[C@]([H])(O[H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])[C@@]4([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])[C@]21O[H] [H]C1=C([H])C2=C(C([H])=C([H])C(F)=C2[H])N1C1=C([H])[C@@]2([H])N(C([H])([H])[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4OC3([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])[C@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C1=NC(=NN1[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)[C@@]([H])(N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=NC([H])([H])C2([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(SC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(OC(=O)C2=C(C3=C([H])C([H])=C(Cl)C(Cl)=C3[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H] [H]N(C1=C2C([H])=C([H])C(=C([H])C2=NC(=N1)C([H])([H])OC([H])([H])[H])C1=C(C([H])=C([H])C([H])=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C(C([H])=C([H])C(Cl)=C2[H])C1=O)C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C1=C(OC([H])([H])[H])C(=O)C2=C(O[H])C(OC([H])([H])[H])=C(O[H])C([H])=C2O1 [H]N(C(=O)C1=C([H])C(=C(OC([H])([H])[H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)N([H])C2=C([H])[C@@]3([H])C(=NC4=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])N5C([H])([H])C([H])([H])C([H])(O[H])C([H])([H])C5([H])[H])C([H])=C4C3=O)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C([H])=C([H])C([H])=C1F)C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C2(OC([H])([H])C([H])([H])O2)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1(N2C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C3=C(F)C([H])=C([H])C([H])=C3[H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]N([H])C1=N[C@@](C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C(=O)C2=NC([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])N=C2[H])(C([H])([H])[H])C([H])([H])C([H])([H])S1 [H]OC1=C([H])C(N([H])C2=C([H])C([H])=NC3=C([H])C(Cl)=C([H])C([H])=C23)=C([H])C([H])=C1C([H])([H])N([H])C([H])([H])C([H])([H])[H] [H]C1=NC2=C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]C1=C2C(=C([H])C(I)=C1[H])N(C(=C2C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H]