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[H]C1=C([H])C(=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)C(=O)N([H])C1=C(C(=O)O[H])C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
C[C@@H]1CN(CCN1C1=NC=C(OCC2=C(C=NC=C2)C#N)C=N1)C(=O)OC(C)(C)C#N
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[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])N([H])C(=O)[C@]([H])(O[H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)OC21C2=C([H])C([H])=C(O[H])C([H])=C2OC2=C1C([H])=C([H])C(O[H])=C2[H]
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[H]O[C@]([H])(C([H])([H])N(C(=O)C1=C([H])C2=C(N=C(O2)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
CC[C@@H](CO)Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](COP([O-])([O-])=O)c1cccc(Cl)c1
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[H]\C(=C(/[N+]([O-])=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
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[H]OC([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C2=C(C3=C(N2C2=C([H])C(N([H])[C@@]([H])(C([H])([H])[H])[C@]1([H])C([H])([H])[H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3=O)C([H])([H])[H]
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[H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C([H])=C([H])O1)C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])SC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(Br)=C([H])N1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H]
[H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C1N=C1C([H])=C([H])C([H])=C(OC([H])([H])[H])C1=C2[H])C([H])([H])C([H])([H])[H]
[H]C1=C(SC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C(O[H])=C2C(O\C(=C(\[H])C3=C([H])N(C4=C3C([H])=C(OC([H])([H])[H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=O)=C1[H]
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=NN(C(O[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H]
[H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(C2=C([H])C3=C(N2[H])C([H])=C([H])C(=C3[H])C(=N[H])N([H])[H])=C1O[H]
[H]\C(=C1\S\C(=N\C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])N(C1=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])[N+]([O-])=O
[H]\C(=C(\[H])C1=[N+](C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C2N1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])\C(\[H])=C1\N(C2=C3C(=C([H])C([H])=C2[H])C([H])([H])C([H])=C([H])[C@@]13[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])N([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N=C(N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C(O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C3=C([H])C([H])=C(OC4([H])C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2C(=O)N(C(=S)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C1=C([H])N=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=NN=C1[H]
[H]C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C2([H])[H])=C1[H])C(=O)C([H])([H])[H]
CC1=C2C(=O)NCC2=CC=C1OCCCN1CCN(CC1)C1=CC=CC2=CC=CC(F)=C12
[H]C1=C2C3=C(N=C(C([H])=C3N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]
[H]N1C2=C([H])C3=C(C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@@]1([H])C([H])([H])[H]
C(C1=CC=CC=C1)C1=NC2=CC=CC=C2N2C=NN=C12
[H]N(C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])[H])C([H])=C23)C([H])=C1[H])C1=C([H])C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(F)C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C([H])=C1N1C([H])=NC2=C(SC3=NC([H])=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C23)C1=O
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])F
[H]C1=C([H])[N+](=C([H])C([H])=C1C([H])([H])C([H])([H])C(=O)[C@]1([H])SC2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C(OC([H])([H])[H])=C([H])C2=C1C(=O)C(=C([H])N2C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])C([H])([H])N(C2=NC([H])=C(N3C([H])=C([H])N=C23)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])SC(=S)SC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]O[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])S1)C([H])([H])[C@]1([H])C([H])=C([H])C([H])=C([H])[C@]1([H])Cl)[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N=C1[H])N([H])[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])([C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]2([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=NC(\C([H])=C(/[H])C(=O)OC([H])([H])[H])=C(C2=C([H])C([H])=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(\O[H])=C1\C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@](N(C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C2([H])[H])(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C#N
[H]C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@@]([H])(C#N)C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]21[H]
[H]C1=C([H])N2C(=NC(=C2C2=C([H])C([H])=C(C#N)C([H])=C2[H])[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C(Cl)=N1
[H]N1C(=O)ON=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])[C@]2([H])C(=C([H])[H])C(=O)O[C@]2([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]2([H])C([H])=C([H])C(=O)[C@@]12C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C(N([H])C2=N[S@](=O)N=C2N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H]
[H]N1C([H])=NC(=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(C1=NC([H])=C([H])C(=N1)N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C#N)C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N(C1=C([H])C([H])=C(OS(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H]
[H]C1=C(N(N=C1C([H])([H])[H])C1=NC(=C([H])C(OC2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])=N1)C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C2C([H])=C([H])C([H])=C(F)C2=NC(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]O[C@@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C(Cl)=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N(C(=O)C([H])([H])[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]