[H]O[C@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)[C@]2([H])OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])OC1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@@]([H])(N1C([H])=NC([H])=C1[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C(C(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]C1=NN=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1C1=C([H])N=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])(F)F)C(=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C(=O)[C@@]2([H])[C@@](C([H])([H])[H])(C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])(C4=C([H])OC([H])=C4[H])C([H])([H])[C@]23C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])N2C3=C(OC([H])([H])[C@]2([H])C([H])([H])[H])C([H])=C([H])C([H])=C3C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]2([H])N(C1=O)C([H])([H])C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C(=O)C1=C(N=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])OC(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2[C@@]([H])(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(SC1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C2=C(OC(=N2)C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]OC(=O)[C@@]([H])(C#N)[C@@]1([H])C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C([H])([H])C([H])([H])Cl [H]N(\C(=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])N2C([H])([H])C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@]2([H])N(C([H])([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C2(OC([H])([H])[H])OC([H])([H])[H] [H]N(C(=O)C([H])([H])[C@]1([H])N(C2=C([H])C([H])=NC(=N2)N2C([H])=NC([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C(\C#N)=C(/[H])C1=C([H])C(=C(Cl)C([H])=C1[H])[N+]([O-])=O)[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(\N=N\C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C(F)C(=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=NN(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2N([H])C(=O)\C(=C(\[H])C3=C4C(=C([H])N3[H])C(=O)N([H])C([H])([H])C4([H])[H])C2=C1[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(OC3=C2C([H])=C(C([H])=C3[H])C2=NOC(=N2)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C(F)(F)F)C(F)(F)F COC1=C(OC)C=C(CNC2=CC(O[C@H]3CCN(C)C3)=C(Cl)C=C2)C(Br)=C1 [H]N(C(=O)C1=C(N=C(C#N)C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C2=NC(C#N)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(\N=N\N(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(F)(F)F)C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(Br)N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])C#C[H])C([H])([H])C1=NC2=C(N([H])[H])C([H])=C(N([H])[H])C([H])=C2N=C1[H])C(=O)O[H] [H]N([H])C(C(=O)N([H])C1=C([H])C(=C([H])N=C1N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=NC2=C(N1[H])C([H])=C(Cl)C(Cl)=C2[H])C1=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1(F)[C@]2([H])C([H])([H])[C@@]([H])(OC([H])([H])C3=C([H])C(Cl)=C([H])C([H])=C3[H])[C@@](N([H])[H])(C(=O)O[H])[C@]12[H] [H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=NC2=C1C(=C([H])N2C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])N(C(=O)N([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])N([C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])C3=C(N(C(=O)C([H])=C3[H])C3=C([H])C(=C(F)C([H])=C3[H])C([H])([H])[H])C2=C1[H] [H]N1C2=C(C([H])=C(S2)C(C(=O)N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])C([H])([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@@]2([H])N([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N(C([H])([H])[H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C(S1)C(=O)OC([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])C1=NN=C(O1)C1=NC(=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C(=S)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])C1=C(N(C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]C1=C([H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]3([H])C([H])([H])C1=C2C(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] O=S(=O)(CCCC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1)C1=CC=CC=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C1=NN2C([H])=C([H])C([H])=C(C2=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C(F)(F)F)C([H])([H])[H] [H][C@](N)(CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1B(O)O [H]N([H])S(=O)(=O)C1=NN(\C(S1)=N/C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])([H])[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(=NN=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])[C@@]2([H])N([C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C2C([H])=C([H])C([H])=C3[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]OS(=O)(=C([H])[H])C1=C([H])C2=C(C([H])=C1[H])[N+]1=C(C3=C([H])C4=C5N(C6=C([H])C([H])=C(C([H])=C6C5(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C5=C([H])C([H])=C([H])C6=C([H])N=C([H])C([H])=C56)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)N([H])[H])C([H])([H])C([H])([H])[C@]4([H])O[C@@]3([H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C2([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])Br)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(C#CC([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]SC([H])([H])[C@@]1(C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])F)C([H])([H])C2([H])[H])=C([H])C([H])=C1Br CC1=CC(O)=CC(C)=C1C[C@H](N)C(=O)N1CC[C@@H](C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](C(=C)C(N)=O)C1=CC=CO1 COC1=CC=C(OC2=C(Cl)C=NN(CC3=C4C=CC=CC4=CC4=CC=CC=C34)C2=O)C=C1 [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C(F)(F)C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1F C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C1=CC=CC=C1 [H]N([H])C1=NC2=NN(C(SC([H])([H])[H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1([H])C2=C([H])C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])[C@]1([H])C([H])([H])N(C(=O)C(OC2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N([H])[C@@]1([H])C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])C(F)(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1N2C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C([H])C([H])=N1)C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C3OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3=C1[H])C([H])([H])C2([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=NC([H])=C2C([H])=C1C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(Br)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2N(C([H])([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])OP([O-])(=O)C([H])([H])P([O-])(=O)OP([O-])(=O)C([H])([H])P([O-])(=O)OC([H])([H])[C@@]2([H])O[C@@]([H])(N3C([H])=NC4=C3N=C([H])N=C4N([H])[H])[C@]([H])(O[H])[C@]2([H])O[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])[H] [H]C1=C(N(C(=C1[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])N=C(C#N)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN(N=N1)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(N=C(O1)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])S1)C(=O)C1=C([H])SC2=C1C([H])([H])C([H])([H])[C@]([H])(C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=NC([H])([H])C2=C1C(OC1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])=NC([H])=C2[H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])N1N=NN=C1C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N(C3([H])C([H])([H])C3([H])[H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])ON1C(=O)C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(S1)C1=C(N([H])C(=N[H])N([H])[H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])([H])[C@@]1([H])C1=C(N([H])C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])[H])C(F)(F)F [H]N(C(=O)OC([H])([H])C1(C([H])([H])OC2=C(C([H])=C(N=N2)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] CC(C)C[C@H](NC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O [H]N1C(=O)C2=C([H])C([H])=C([H])C3=C2[C@@]([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C3([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])N(C1=C([H])C([H])=C(C#N)C(Cl)=C1[H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1([H])OC([H])([H])[C@]([H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C(OC([H])([H])C([H])([H])[H])=C2[H])[C@@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=C([H])C([H])=NC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(N1[H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C2=C(C([H])=C(SC([H])([H])[H])C([H])=C2[H])C1=O [H]N(C1=NC2=C(C([H])=N1)C([H])=C(SC1=C([H])C([H])=C([H])C([H])=C1F)C(=O)N2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] CCCC1=C(C(=O)OCC)C(C(=O)OCC)=C2N1N=C(C=C2C(C)(C)C)N1CCOCC1 [H]N(C(=O)[C@]1([H])C(=O)N2C3=C(SC4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C13)C1=C([H])C(F)=C([H])C([H])=C1F [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])C2=NN(N=N2)C([H])([H])[H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]SC([H])([H])[C@]1(C(=O)N([H])[C@]([H])(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(I)C([H])=C1[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=N1 [H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]N1C(=O)C(C2=C([H])N(C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[H])=C(C1=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(C3=C1C([H])([H])C1(N([H])C3=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C2C([H])=C(N=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C1=C(N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)C1=O)C1=C([H])C([H])=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H] [H]N=C1OC2=C(C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3OC2=N[H])C([H])([H])C1([H])[H] [H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C2(C3=C([H])C([H])=C(C([H])=C3[H])N3C(=O)C4=C(C(=NN4C4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])[C@]2([H])C([H])([H])C([H])([H])N(C3=C([H])N=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[C@]12[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=S)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2N(C([H])=NC2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NC([H])=C([H])N=C23)C([H])=C(Cl)C(Cl)=C1[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(Br)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H] [H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C12 [H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=NC2=C(N=C(C(=O)N2C([H])(C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])C(=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(O[H])C([H])=C2C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])Br [H]O\C(OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C(\C#N)/C(=N\[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])/N([H])C1=C([H])C2=C(OC(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(I)C([H])=C1[H] [H]OC(=O)C1=C(N([H])C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C2=NN(C([H])=C2[H])C2=C([H])C([H])=C(O[H])C([H])=N2)C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])OC2=C([H])C([H])=C(C([H])=C2O1)C([H])([H])N([H])C(=O)[C@]1([H])SC([H])([H])C([H])([H])N1C(=O)C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F [H]C1=C([H])C(=C2C3=NC(=NN3C(SC([H])([H])C#N)=NC2=C1[H])C([H])([H])[H])C(F)(F)F [H]N([H])C1=NC([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=N4)C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C11C2=C([H])C([H])=C(C([H])=C2OC2=C1C([H])=C([H])C(=C2[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] CCOCCNC(=O)C1=NN=C(C=C1)N1CCN(CC1)C(=O)C1=CC=CC=C1C(F)(F)F [H]N(C(=O)C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C(C(=NN1C([H])([H])C([H])([H])F)C1=C([H])C([H])=C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=N2)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=NN2N=C(C(=C2C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=N1)C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(C([H])=C([H])C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]S[C@@]1([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C2=C(F)C([H])=C([H])C(F)=C2[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N1C([H])=NC([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C(=NN1C1=C(Br)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C#N)C(OC([H])([H])C([H])([H])[H])=NC(=C1[H])C(=O)N([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]C1=C(C(=C2C([H])=C([H])C([H])=C([H])N12)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])N1C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=N3)C([H])([H])C2([H])[H])=N[C@]2([H])SC(=C([H])[C@]2([H])C1=O)C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(O[H])O[H])C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N([H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)O2)C([H])([H])[H] [H]N([H])C1=C(Br)C([H])=C(C([H])=C1Cl)S(=O)(=O)N([H])C1=NN=C(S1)S(=O)(=O)N([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OS(=O)(=O)C1=C(N([H])[H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C([H])C(OC([H])([H])[H])=C1N(C(=O)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C1(F)F)C1=C([H])C([H])=C2C(=C1[H])C(=NC2([H])[H])C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C(Cl)C([H])=C([H])C2=C1OC([H])([H])O2 [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C#CC([H])([H])N1C(=O)N(C2=C(N([H])C(=N2)C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C1=O)C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C1=NC(Cl)=NC2=C1N=C([H])N2C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])OC([H])([H])C(F)(F)C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]1(N([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C2=C(C([H])=C(S2)C(C(=O)N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C2[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2O[C@]1([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [3H]C(O)[C@H]1CN(CC2=CNC3=C2N=CNC3=O)C[C@@H]1O [H]OC1=C([H])C([H])=C2OC3=C(N=C(N([H])C3=O)C3=C(Cl)C([H])=C([H])C([H])=C3[H])C2=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N1C2=C([H])C(Br)=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1=O [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(N([H])C([H])([H])C([H])([H])N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C(C2=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C(=C(SC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])N2[H])C([H])([H])[H])C(=N1)N([H])[H] [H]N1C([H])=C([H])N([C@@]([H])(C1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(Cl)C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(N=C(C([H])=C1[H])C(F)(F)F)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(C(=O)OC([H])([H])N2C(=O)C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3OC([H])([H])[H])S2(=O)=O)C(Cl)=C1[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=S)N([H])N([H])C(=C1/C(=O)N(C2=C([H])C([H])=C(F)C([H])=C12)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])\C([H])([H])[H] [H]N([C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])Cl)C([H])=C1[H] [H]N([H])C1=NC(N([H])[H])=C2N=C(C([H])=NC2=N1)C([H])([H])N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])[N@+](C([H])=N1)(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[C@]1([H])OC([H])([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(OC([H])([H])C1([H])C([H])([H])C1([H])[H])C(=O)C1=C(F)C([H])=C(F)C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C1=C([H])C(=C([H])S1)N1C(=O)O[C@@]2(C1([H])[H])C([H])([H])[N@]1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C1([H])[H] [H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(Br)C(Br)=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N1N=C(N=C1C1=C([H])C([H])=NC(SC([H])([H])[H])=C1[H])C1=C([H])C([H])=NC(=C1[H])C([H])([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1([H])[H])C([H])([H])OC(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=C([H])C2=C1C(=C([H])S2)C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] CC[Si](CC)(C1=CC(C)=C(OCC(=O)C(C)(C)C)C=C1)C1=CC=C(OCC(=O)C(C)(C)C)C(C)=C1 [H]N1N=C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C(N2[H])C2=NN([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])C([H])=N1 [H]N(C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(N([H])C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C(F)C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]12C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]11C3=C(C([H])=C([H])C(OC([H])([H])C(=O)N([H])[H])=C3[H])C([H])([H])[C@@]2([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1I)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])F [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC2=C3C(=C([H])C(Cl)=C12)C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]31[H] [H]N(C1=NC([H])=C2C(=C1[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]1([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=NC(C#N)=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=C(N=C(S1)C([H])([H])[H])C#CC1=C([H])C(F)=C([H])C(=C1[H])[N+]([O-])=O [H]OC1=C2N([H])C(=NS(=O)(=O)C2=C([H])C(Cl)=C1[H])N([H])C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]