[H]C1=C([H])C(=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N(C(=S)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]C1=NN2C([H])=C([H])C(C#N)=C([H])C2=C1\C(=N\N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C2N([H])C(=O)N([H])C2=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C#CC2=C([H])N(C(=O)C([H])=C2[H])C([H])(F)F)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1C(=C([H])C(\C([H])=C2\C(=O)N([H])N(C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])[H]
[H]N1C(=O)C2=C(C3=C1C([H])=C([H])C(O[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])=C3[H])C([H])([H])C([H])([H])SC2([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]([H])(N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])[P@](=O)(OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(N([H])C(=O)[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])O[H])C2([H])[H])C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])Br
[H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C(OC([H])([H])[H])=C([H])C([H])=C1[H])C2([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C1=C(OC2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])OC([H])(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H]
[H]N1C2=C([H])C([H])=NN2[C@]([H])(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1[C@@]1([H])N(C2=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=N1)C([H])=C([H])C([H])=C2[H]
[H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=NN(N=C1[H])C1=C([H])C([H])=C(C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C(=O)N(C(=O)C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=NC2=C(S1)C([H])([H])C1=C(C(=C([H])C(OC([H])([H])[P@@]3(=O)OC([H])([H])C([H])([H])[C@]([H])(O3)C3=C([H])C([H])=C(N=C3[H])C([H])([H])[H])=C21)C([H])([H])[H])C([H])([H])[H]
[H]O[C@@]1([H])C([H])=C([H])[C@@]23C4=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C4O[C@@]2([H])C1([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(S2)[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=NOC(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C(SC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C(F)(F)F
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=N/OC([H])([H])C([H])([H])[H])\C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C1=NN=NN1C1=C(Cl)C(=C(F)C([H])=C1[H])C(F)(F)F
[H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C2([H])[H]
[H]OC([H])([H])C([H])([H])N([H])C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H]
[H]OC1=C(N([H])C(=O)[C@@]2([H])C([H])([H])C2(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O
[H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])N(C(=O)[C@@]1([H])C([H])([H])[H])C([H])([H])[H])=C(C#N)C([H])=C2[H]
[H]C([H])=C([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2C(N=C([H])N=C2N2C([H])([H])C([H])([H])N(C(=O)N([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H]
[H]C1=NC(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C(=O)N([H])C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C1[H]
[H]C1=C(N=C2C([H])=C([H])C([H])=C([H])N12)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2C2=NC(=NN12)C([H])([H])[H]
[H]OC([H])([H])C(N([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C(F)C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H]
[H]C1=C([H])N=C(C([H])=N1)C1=NN=C(SC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])N1C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])SC([H])=N1
[H]OC([H])([H])C1=C2N=C([H])C(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(N([H])C3=C([H])C([H])=C(F)C([H])=C3C([H])([H])[H])C2=C([H])C([H])=C1[H]
[H]N1C(=O)N(C(=O)\C(=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2[N+]([O-])=O)C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])N2C(=C1[H])C(=NC1=C2N=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C(Br)SC(=C1[H])S(=O)(=O)N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(C([H])=C2N1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]N(C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])[H]
[H]N(C(=O)N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])P(=O)(OC([H])([H])C([H])([H])[H])OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC([H])([H])C(N([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])(C([H])([H])O[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])[C@]1([H])OC([H])([H])[C@]([H])(C([H])([H])OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])C([H])([H])[H]
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[H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C(=C([H])C([H])=C12)[N+]([O-])=O)C([H])([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H]
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[H]N([H])C(=N/N=C(/[H])C1=C([H])C([H])=C(F)C([H])=C1[H])\N([H])\N=C(\[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]O[C@]([H])(C(=O)N([H])C1=C(C([H])=C(N([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C([H])([H])[H])[C@]([H])(N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C(N([H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1OC([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C(Cl)=C1[H])(C([H])([H])[H])C([H])([H])[H]
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[H]OC([H])([H])[C@]1(OC(=O)C(=C(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C#CC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H]
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[H]N([H])C(=O)C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])O1
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[H]N(C(=O)C1=C([H])SC(=N1)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F
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[H]OC1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])C([H])([H])C([H])([H])S1(=O)=O)C2=O
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[H]SC1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H]
[H]C1=C2C(=NN1C([H])([H])[H])C1=C(SC(=C1C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NS2)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]C1=C([H])N(C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12
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[H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=N/S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])\N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H]
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[H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
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[H]O[C@]1([H])N(C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])N=C1[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=NN2C(N=C([H])C([H])=C2[C@@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C1C1=C([H])C([H])=C(Cl)C(OC([H])([H])[H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=C(Cl)C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
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[H]N(C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C2N=C(N=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
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[H]OC1=C2C(=O)C([H])=C(OC2=C([H])C(OC([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(C(=O)C([H])([H])[H])=C2OC1=O
[H]SC([H])([H])[C@@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S([O-])(=O)=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H])C([H])([H])C#CC([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C3=C([H])N=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H]
[H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H]
[H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(O[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
CC(C)N1CCN(CC1)C(=O)C1=CC=C2SC=C(CN3CCCCC3)C2=C1
[H]OC(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])N(C3=C2C(=NC([H])=N3)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])SC(=S)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C2[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])N([H])C([H])([H])[H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)N3C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[C@@]3([H])C2=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])N1C2=NC3=C(N2C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
C[B]1234[B]567[B]89%10[B]55%11[B]88%12[B]%13%14%15[B]11([B]2%132[B]365[C]%118%142C2=CC=C(O)C=C2)[B]9%12%15=[C]47%101
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(SC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C([H])N(C2=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C([H])N=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])N1N=C([H])C(N([H])C2=NC([H])=C(Cl)C(=N2)N([H])[C@]2([H])[C@@]3([H])C([H])=C([H])[C@]([H])(C3([H])[H])[C@]2([H])C(=O)N([H])[H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C(=O)N(C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=C([H])N2N=C(N=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(C#N)C([H])=C1[H]
[H]OC1=C([H])C(Cl)=C(C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C(=S)N([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]N([C@]1([H])C([H])([H])C([H])([H])[C@](C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C2=C([H])N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])N=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C2N=C(N([H])C2=C1[H])N(C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=NC([H])=C1[N+]([O-])=O)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C(=N1)N([H])[H])C([H])([H])OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C(C([H])=C23)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C([H])=C([H])C(Cl)=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H]
[H]O[C@@]12N3C([H])([H])[C@]4(C(=O)\C(=C(/[H])C5=C6C([H])=C([H])C([H])=C([H])C6=C([H])C([H])=C5[H])C3([H])[H])[C@@]([H])(C3=C5C([H])=C([H])C([H])=C([H])C5=C([H])C([H])=C3[H])[C@@]3([H])N(C([H])([H])C([H])([H])C3([H])[H])[C@@]14C(=O)C1=C([H])C([H])=C([H])C([H])=C21
[H]OC1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[C@@]1([H])C(=C([H])C([H])([H])[C@@]2([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H]
[H]OP(=O)(O[H])C([H])(N([H])C1=NC(=C([H])S1)C([H])([H])[H])P(=O)(O[H])O[H]
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[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C(=O)[C@]3([H])C([H])([H])N(C([H])([H])[C@@]3([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]C1=C([H])C([H])=C(O1)C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=NN=C1C1=C([H])C([H])=C([H])C([H])=N1
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C(I)C([H])=C2C(=O)N([C@]([H])(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1=O
[H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=C(O1)C(=O)N([H])C1=NN([H])C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1=O)C(=O)OC([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3C([H])([H])SC2=C([H])C([H])=C(Cl)C(Cl)=C2[H])[C@]([H])(O[H])[C@]1([H])O[H]
[H]OC(C1=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C3(O[H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C2C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])[C@]2(C3=C(F)C([H])=C([H])C(F)=C3OC([H])([H])[C@@]12[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[H]
[H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C2([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])O[H]
[H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=C([H])C2=C(N([H])C(=O)N2[H])C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1OC([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H]
[H]N1C([H])=C([H])C([H])=C1C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H]
[H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C(F)C(F)=C(F)C(F)=C1F
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]OC1=C(C([H])=C2C(N([H])N=C2C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H]
[H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N3C(=O)C4=C(C3=O)C(F)=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C(\[H])=C(/[H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C(N([H])S(=O)(=O)C(F)(F)F)C([H])=C([H])N=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H]
[H]N([H])C1=C2C(=NC([H])=N1)N(C([H])=C2C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H]
COC(=O)C1=CC(NC(=O)N(CCC(C2=CC=CC=C2)C2=CC=CC=C2)CC(C)C)=CC=C1
[H]OC1=C(C(O[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])C2=NN([H])N=N2)C([H])([H])[H])=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N([H])C(=S)N([H])\N=C(/C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C([H])C(Br)=C1[H]
[H]C1=NC([H])=C2C(=NN=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C2=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1([H])[H])C1=C3C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C1=NC([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H]
[H]OC(=O)C(C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C(O[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])N(C([H])=N1)C([H])([H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(OC(F)(F)F)C([H])=C3[H])=C([H])C([H])=C12
[H]C1=C([H])C2=C([H])C(=C([H])C([H])=C2C([H])=C1O[C@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=NC(=C([H])C([H])=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(Br)C([H])=C2C(=NN([H])C2=N1)N([H])C(=O)C1([H])C([H])([H])C1([H])[H]
[H]N([H])C(=[N+]([H])[H])C1=C(Cl)C([H])=C2N([H])C(=C([H])C2=C1[H])C1=C([O-])C(=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=N1)C#N
[H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C([H])([H])C([H])(N1C([H])([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H]