[H]C1=C(C2=NOC(=N2)[C@@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(F)C2([H])[H])[N+]([H])([H])[H])C(F)=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C([H])=C(N([H])C2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N1C([H])=C([H])C([H])=C(C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C([H])=C(OC([H])([H])C3=C(ON=C3C3=C(Cl)C([H])=C([H])C([H])=C3Cl)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C2=C1[H] [H]O[C@@]([H])(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])N1N=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]([H])(O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])SC(=N1)N([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C(N([H])C2=NC([H])=C1Br)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C(C(=O)OC([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H] [H]C1=NC2=C(O[C@]([H])(C([H])([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])ON=C3C4=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C4OC([H])([H])[C@]23[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C(=C1C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 CC[C@@H](NC(=O)C1=CC=NC2=CC=CC=C12)C(=O)N1CCC[C@H]1B(O)O [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C3(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C2C(OC(=O)[C@]([H])(C(=O)OC([H])([H])[H])C2([H])[H])=C1[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2(C#N)C3=C(OC([H])([H])C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N([H])[C@](C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C#CC([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=N2 [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@@]1([H])N(N=C(C2=C([H])C(F)=C([H])C([H])=C2F)C1([H])[H])C(=O)C([H])([H])[H] [H]OC1=C(C([H])=C(Br)C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1[H])C(=N[H])N([H])[H] [H]OC(=O)[C@@]1(OC2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]12C([H])([H])C(=O)\C(=C(/[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])N(N=N1)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(OC2=C([H])C([H])=C([H])C(=C2[H])C2=C3C([H])=C([H])C([H])=C(C3=NC([H])=C2C([H])([H])[H])C(F)(F)F)=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])SC1=NN=C(S1)N([H])C1=C([H])C([H])=C([H])C([H])=C1F)C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C2([H])[H])C1=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\[C@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])C1=NC([H])=C([H])N=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C2=C(C([H])=C1[H])C(=C(C(=O)O2)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C2(C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=NC([H])=N1)N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] ON(=O)C1=CC=C(NC2=C3N=CNC3=NC(=N2)N2CCOCC2)C=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1([H])C3([H])C([H])([H])C([H])([H])C(O[H])(C#CC4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])N([H])C([H])([H])C4([H])OC5([H])OC6([H])C([H])(OC([H])(OC7([H])C([H])(OC([H])(OC8([H])C([H])(OC([H])(OC9([H])C([H])(OC([H])(OC%10([H])C([H])(OC([H])(OC%11([H])C([H])(OC([H])(OC4([H])C([H])(O[H])C5([H])O[H])C([H])(O[H])C%11([H])O[H])C([H])([H])O[H])C([H])(O[H])C%10([H])O[H])C([H])([H])O[H])C([H])(O[H])C9([H])O[H])C([H])([H])O[H])C([H])(O[H])C8([H])O[H])C([H])([H])O[H])C([H])(O[H])C7([H])O[H])C([H])([H])O[H])C([H])(O[H])C6([H])O[H])C([H])([H])O[H])C3(C([H])([H])[H])C([H])([H])C([H])([H])C21[H] [H]C1=NC([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C2=C(C3=C(S2)N2C(=NN=C2[C@]([H])(N=C3C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])C([H])([H])C2=C1C([H])=C([H])N2C([H])([H])[H])C([H])([H])[H] [H]C1=NC(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C2N=C(N(C2=N1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C(=C([H])C([H])=C1SC(F)(F)F)[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N(C1=NC(=O)\C(N1[H])=C1\C2=C(N([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@](C(=O)N([H])C1=C([H])C([H])=C(N([H])[H])C(=C1[H])C(F)(F)F)(C([H])([H])[H])C([H])([H])Br [H]C1=C2C(=NC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(O1)C1=NC(=C(O1)SC([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C2C([H])=NC(SC([H])([H])[H])=NC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C([H])=C([H])C([H])([H])C1=C(N([H])C2=C(C([H])=C([H])C([H])=C2OC([H])([H])[H])C1=S)C([H])([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([H])N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=NC([H])=C1[H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC([H])(F)F)C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1(SC([H])([H])C(=O)[C@]2([H])C([H])([H])N(C(=O)[C@@]([H])(SC([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])[C@@]12[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=[N+]([O-])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(ON=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])[C@@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@@]2([H])S[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(N2C([H])=C([H])SC2=N1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(F)(F)F [H]C1=C([H])C(I)=C(C([H])=C1[H])N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)O1)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C(F)=C2[H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])C1=C([H])C(F)=C(C([H])=C1[H])C1=NC2=C(S1)N=C(C([H])=C2[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=NC3=C([H])N=C(N=C23)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])C2=C(F)C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] ON(=O)C1=CC=C(COC(=O)N(CC=C)C2CCN(C[C@H]3CN(C[C@]3(O)C3=CC(F)=CC=C3)C(=O)C3CCCC3)CC2)C=C1 [H]OC1=C(Cl)C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=O)OC([H])([H])[C@@]2([H])N(\[N+]([O-])=N\OC([H])([H])OC(=O)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C(OC(=O)C([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C1=NC([H])([H])C2=NN=C(N2C2=C1C([H])=C(C#CC([H])([H])N1C(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C(C1=O)=C34)C([H])=C2[H])C([H])([H])[H] [H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[N+]([O-])=O)C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])[C@@]1([H])ON=C(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C(=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])\C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C1([H])[H] [H]C1=C([H])C(=C([H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]OC(C1=NC([H])=C(C([H])=C1[H])N(C(=S)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[C@]1([H])C([H])([H])OC([H])([H])C1([H])[H])(C(F)(F)F)C(F)(F)F [H]OC1=C(C#N)C([H])=C([H])C([H])=C1N([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)C1=O [H]N([H])C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C1=C([H])C(=C([H])C([H])=C1C2([H])[H])C([H])([H])[H] COC1=CC2=C(CN(C[C@]3(NC(=O)NC3=O)C#CC3=CC=C(C=C3)C(C)(C)C(N)=O)C2=O)C=C1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(SC(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])N=C([H])N=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])N(C(=C1[H])C1=N[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])O1)C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]1(C([H])([H])[H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3F)C([H])=C2[H])C1([H])[H] [H]OC(=O)C(=C(/[H])C1=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1OC([H])([H])O2 [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C#N [H][C@@]12C[C@@H]3C[C@@H](C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)CN1N=C(CCC(=O)OC(C)(C)C)N=C1CC1=CC=CC=C1 [H]N1C(=O)N(C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N(C([H])([H])C(=O)N1N=C([H])C([H])([H])[C@]1([H])C#N)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C(=N1)N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(N=C(S1)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C(Br)C([H])=C2OC([H])([H])[H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C(=O)N([H])C1=C(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C2N([H])C(=O)C([H])=C([H])C2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]N([C@]1([H])C([H])([H])N2C(=O)N(C3=C([H])C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C([H])([H])[C@@]2([H])C1([H])[H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=NC(=NC([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] CS(=O)(=O)C1=CC(NC2=NC(NC3=C4N=COC4=CC=C3)=CC=N2)=CC=C1 [H]OC([H])([H])C#CC([H])([H])O[C@]1(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C2SC(=NC2=C([H])C(Cl)=C1[H])N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]2([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)OC([H])([H])[C@]12OC(O[C@@]1([H])[C@]1([H])OC(O[C@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])C([H])([H])[H])N1C([H])([H])[C@@]([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C(=O)N(C2=C(N=C(SC3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C1([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C(C#CC2=C([H])N=C([H])N=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(S[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C(=O)C2=C(O[H])C3=C([H])C(F)=C(F)C([H])=C3N=C2O[H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(=C2C3=NC([H])=C(I)C([H])=C3C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@]([H])(O[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=NC(=C([H])N2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] COCCC1=CC=C(Cl)C(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2C2=CC=C(OCC3=CC(=NO3)C3=C(Cl)C(F)=CC=C3F)N=C2)=C1 [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1F)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C(\[H])=C(/[H])[C@]([H])(N(C(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])[C@@]1([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=NC([H])=C(N=C1[H])C1=NN=NN1C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N3C(=O)[C@@]4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]4([H])C3=O)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])[C@@]1([H])N=C(C2=C([H])C3=C(N([H])C(=O)C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H] [H]N([H])C([H])([H])C1=C(C([H])=C([H])C(OC([H])([H])[H])=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C3N(N=C([H])N=C3N([H])C3=C([H])C(Cl)=C(OC([H])([H])C4=C([H])N=C([H])C(=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N([H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C(=O)OC([H])([H])[H] [H]OC(=O)C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])S[H] [H]O[C@@]12C([H])([H])C([H])([H])C(=O)[C@]3([H])OC4=C(N([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]1([H])C(\[H])=C(/[H])[C@]([H])(O[H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] O=C(NCCCN1CCCC1=O)C1=CN=C(NCCC2=CC=NC=C2)N=C1NC1=CC=CC=C1 [H]N1[C@@]([H])(C([H])([H])[H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])C([H])([H])C2=NOC3=C2C([H])([H])C([H])([H])C2=C([H])C(O[H])=C([H])C([H])=C32)C([H])=C([H])C([H])=C1[H] [H]OC1=C2C([H])=C([H])C(=NC2=NC([H])=C1C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C(=O)[C@@]([H])(N([H])C2=C([H])C([H])=C(C([H])=C2C1([H])[H])C(=O)N([H])C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)O[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1([H])C2=C(O[C@]3(C([H])([H])C([H])([H])C3([H])[H])C1([H])[H])N=C([H])C(=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC([H])=C([H])O1 [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])[C@@]1([H])ON=C(C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])C1=C(N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])[C@]1(C([H])([H])N([H])C2=O)C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C(=C1[H])C([H])([H])N([H])OC([H])([H])C(O[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1SC([H])=C([H])C1=O)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])[C@]1([H])C([H])([H])OC2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1([H])[H] [H]N(C1=N[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(C(=O)OC([H])([H])[H])[C@]([H])(N1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NSC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(F)C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])[C@]1(OC(=O)\C(O1)=C(\[H])C([H])([H])C([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F CC(C)C[C@H](CO)NC1=NC(SCC2=CC(Br)=CC=C2)=NC2=C1SC(N)=N2 [H]C1=C(N(C(=C1C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)[C@]1([H])N(C2=C([H])C([H])=C(C(=O)N([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C(SC([H])([H])C([H])([H])C([H])([H])[H])=N2)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2C3=C(C4=C(N3[H])C([H])=C(C([H])=C4[H])C3=C([H])C(=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1[H] [H]OC1=C(F)C([H])=C2C(=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H][C@@]12CCN(CCCCCCNC(=O)CCCCCCC(=O)NCCCCCCN3CC[C@@]4([H])COC5=C(C=CC=C5)[C@@]34[H])[C@]1([H])C1=C(OC2)C=CC=C1 [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C(C(F)=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C(N(N=C2C#N)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1=O [H]N([H])C1=C([H])C(F)=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@@]2([H])N3C4=C(OC([H])([H])C3([H])[H])C([H])=C([H])C([H])=C4[C@@]2([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])[C@]2([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C([H])C2=C1[H] [H]N([C@]([H])(C1=NC([H])([H])[C@@]([H])(N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C(=O)N([H])S1(=O)=O)S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F [H]N(C1=NC(=NS1)C1=C([H])N(N=C1C([H])([H])[H])S(=O)(=O)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N(N=N1)C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)[C@]1([H])C([H])([H])[C@@]1([H])C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N(C(=O)C1=C(N(C2=C([H])C(=C([H])C([H])=C12)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C(N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])N=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(N([H])C3=NC([H])=C([H])C([H])=N3)C([H])=C(C([H])=C2C([H])=C1[H])[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(C#N)=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C(=O)[C@@]([H])(N(C([H])([H])C2=NN([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C(OC([H])([H])[H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC(=CN=C3)C3=CN=C(N)C=C3)C2=O)C=C1 [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C([H])=C1C1=C2C([H])=C(N([H])C2=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=C([H])C2=C1[C@@]1(C([H])([H])N([H])C2=O)C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC(=N1)C1=C([H])C2=C(O1)C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C2N=C3OC([H])([H])C([H])([H])C([H])([H])C3=C([H])C2=C1[H] [H]N([H])C(=O)C1=C([H])C(O[C@]2([H])C([H])([H])[C@@]3([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])=C([H])N=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C2=C([H])C(C#N)=C(C#N)C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C([H])=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C2N=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C2=NC([H])=N1 [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(Br)C([H])=C3[H])=C([H])C([H])=C2O1 [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1(C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C2([H])N(C([H])(C3=C(Cl)C([H])=C([H])C([H])=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]ON(C([H])=O)[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(C([H])=C(C([H])([H])[H])C([H])([H])[H])=C([H])C(=C1[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C(C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C(ON=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N1C(=C([H])C2=C1C([H])([H])C([H])([H])N([H])C2=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1OC([H])([H])O2 [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N1N=C(SC1=S)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])OC(=O)[C@@]([H])(N([H])[H])C1=C(N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=N[C@]2([H])N(C(=O)N(C(=O)[C@]2([H])N1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H]