[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C1=C([H])C(=C([H])C(F)=C1[H])C(F)(F)F)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(\C(=N/C(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C([H])C(=C([H])N=C1N([H])C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)C(F)(F)F [H]C1=C([H])C(=C([H])C(=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N(\C([H])=C(/[H])C(=O)C1([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)N1C([H])([H])C([H])([H])C3(OC([H])([H])C([H])([H])O3)C([H])([H])C1([H])[H])C2=O)S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1C(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C2C([H])=C(C(OC([H])([H])[H])=C([H])C2=NC([H])=N1)[N+]([O-])=O)C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=NN=C(C3=C([H])C([H])=C([H])C([H])=C3Cl)C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])N1C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C1=C([H])C([H])=C(Cl)N=C1[H])C2([H])[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN(N=N1)C([H])([H])C([H])([H])C#N [H]C1=NC(=C(C([H])=C1[H])[C@@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(F)=C1[H])N1N(C(=C(C1=O)C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C(C([H])=C([H])[H])=C1[H])C1=C([H])C([H])=C(O[H])C(=C1C([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#CC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)N(C([H])([H])[H])[C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C1=C(C3=C2C([H])([H])N(C([H])=O)C3=O)C([H])([H])C([H])([H])C1([H])[H] CCNC(=O)CC#N [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NN=C(O1)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)[C@@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]O[C@]([H])(C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(N(C2=C1C([H])=NC(=N2)C#N)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C(N(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] CC(=O)N[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)NC(=O)OC(C)(C)C)C(C3)C2 [H]C#CC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C([H])([H])SC1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F [H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C(\[H])=C(/[H])C2=C(C3=C([H])C([H])=C(F)C([H])=C3[H])C3=C([H])C(Cl)=C([H])C([H])=C3N=C2C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N1C(=NC([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C(S2)C([H])=C([H])C([H])=C1[H] [H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])O1)C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C([H])C(Cl)=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=C([H])C(N([H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C2[H])=C1[H])C1=C([H])N=C(S1)C([H])([H])[H] [H]C#CC([H])([H])SC1=NC2=C(C3=C(S2)C([H])([H])C([H])([H])C3([H])[H])C(=O)N1C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C(F)=C([H])C([H])=C23)C([H])([H])C2=C([H])C([H])=C(Cl)S2)C([H])([H])C1([H])[H] CC(C)C1=C(CC2=CC=C(CCCC(=O)NCCCO)C=C2)C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=NN1 [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] COC1=CC(=CC=C1Cl)N1CCN(CC1)C(=O)CN1N=C(C(Br)=C1C)C(F)(F)F [H]C1=C2N(C(=O)C(=C(C#N)C#N)C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C([H])=C([H])C(=NC2=C1O[H])C(=O)N([H])C([H])([H])C1=C(O[H])C([H])=C(O[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])SC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C(=O)ON1C(=O)C([H])([H])C([H])([H])C1=O [H]O[C@@](C1=C([H])C([H])=C(OC2=C3C([H])=C(SC3=C([H])N=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])C(=O)C1=C([H])C([H])=C(OC2=C3C([H])=C(SC3=C([H])N=C2[H])C(=O)N([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3O2)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C([H])C2=C1N(C([H])([H])C1=C(N=C(C([H])=C1[H])C(F)(F)F)N2[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C4=C([H])C([H])=C(O[H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)O[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(Cl)N=C3[H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F)C1=NN(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]N(C1=NC([H])=NC2=C([H])N=C(OC([H])([H])C([H])([H])N3C(=O)C([H])([H])C([H])([H])C3([H])[H])C([H])=C12)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]1([H])O[C@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]([H])(O[H])[C@@]1([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])SC([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C(C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])=C12 [H]C1=C([H])C(F)=C([H])C(=C1[H])C([H])([H])OC1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OS([O-])(=O)=O)C([H])=C1[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C(=O)O[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H] [H]S\C(=N/N(N([H])[H])C1=C(F)C(F)=C(F)C(F)=C1F)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N(C1=C([H])C([H])=C(OC([H])([H])[H])N=N1)C1=C([H])C2=C(OC([H])([H])C([H])([H])N2C2=NC3=C(S2)C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(N([H])C(=O)C(F)(F)C(=O)[C@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1N=NC2=C([H])C([H])=C([H])C([H])=C12 [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H] [H]C1=NC([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])[C@]2(O[C@]1(C([H])([H])[H])[C@@]1([H])C(=O)N(C(=O)[C@@]21[H])C1=C([H])C(I)=C(C#N)C([H])=C1[H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] ClC1=CC=CC=C1C1=C(N=CO1)C1=CC2=C(S1)C1=NC=CC=C1OCC2 [H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C([H])C3=C(C([H])=C2[H])N(C([H])=C3[H])C([H])([H])C([H])([H])OC([H])([H])[H])C(Cl)=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])C1=C(N(C([H])=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(\N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])=C(\[H])[N+]([O-])=O)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3C([H])([H])C([H])=C([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(Cl)C(=C1[H])C1=NN(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])[C@]1([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C([H])C(OS(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C(F)(F)F)=C3[H])=C2C1([H])[H] [H]N=C(N([H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])N([H])C2=C1C([H])=C(Cl)C([H])=C2[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C(=O)C3=C([H])C([H])=C([H])C(=C23)C([H])([H])N2[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])N=C1[H])C1=C([H])C2=C(N=C1[H])N([H])N=C2C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=NOC4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C2([H])[H])=C1[H] [H]\C(=C(/[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])SC2=C([H])C(O[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1OC([H])([H])O2)S(=O)(=O)C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C(N([H])C2=NC(=C([H])S2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])=C1[H] [H]C1=C([H])[N+](=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[N+]1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=[N+]([O-])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=N[H])N([H])[H])C2([H])[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]O[C@@](C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C([H])S2(=O)=O)C([H])=C1[H] [H]N1N=NN=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(N(C(=O)C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C(=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C([H])C(N([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N[H])N([H])[H] [H]N([H])C(=O)C1=C([H])C(=NN=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1[C@]([H])(N1C(=O)N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N1C2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])C([H])=C([N+]#[C-])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C2([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N=C4C([H])=C([H])C([H])=NN34)C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[N+]([O-])=O [H]O[C@]([H])(C([H])([H])N=[N+]=[N-])[C@@]([H])(O[H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CN1C=CC2=C1C(OC1=CC=C(NC(=O)NC3=CC=CC=C3Cl)C=C1)=NC=N2 [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C2C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])N(N=N1)C([H])([H])C1=C([H])C(Br)=C(Br)C(Br)=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC(=NC(=N2)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC(=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)(C([H])([H])[H])C(F)(F)F [H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1(C2=C([H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C([H])=NN2N=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1([H])N(N=C(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C1([H])[H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])N=C([H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])[H])[C@@]([H])(N(C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(O[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1(OC([H])([H])C([H])([H])O1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=C([H])N2C([H])([H])[H])C1=S)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=NC([H])=C(F)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C(=NC([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)C4=C([H])C([H])=C([H])C([H])=C4[H])C(=O)[C@]3([H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=N1)C1=C([H])N=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])[N+]([O-])=O)S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C(=N1)C1=C([H])C([H])=C([H])O1 [H]OC1=C([H])C([H])=C(C([H])=C1F)C(=O)N([H])\N=C(/[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])O[H] [H]OC1=NC2=C(N=C1O[H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(OC(=O)C([H])([H])[C@@]2([H])SC(=O)N([H])C2=O)C([H])=C1[H] [H]N([H])C(=O)[C@]([H])(N([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C([H])C2=C(N([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C3=C(C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=S)N([H])\N=C1\C2=C(C([H])=C(F)C(F)=C2[H])S(=O)(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2C(=O)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1C1=C(C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(Cl)=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])C([H])([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)OC([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=NC(=C([H])C(=C1[H])C1=C([H])N=C2N=C(OC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(C([H])=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])=C1[H] COC1=CC=C(C=C1)C(CCC(N)C(O)=O)(C1=CC=CC=C1)C1=CC=CC=C1 [H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N([H])C2(C3=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N=C(N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C2=C(C([H])=C(Cl)C([H])=C2[H])C(=NC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)C1=C(C(=O)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2O1)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC2=C([H])C([H])=C(OC([H])([H])[H])C(=C2[H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(P([O-])([O-])=O)S([O-])(=O)=O)=C([H])C([H])=C1F [H]OC(=O)C([H])([H])C([H])([H])[C@@](N([H])C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C2=NC(=NC(N([H])[H])=C2C1([H])[H])N([H])[H])(C(=O)O[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C(N([H])C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]2([H])C([H])=C3C4=C([H])C([H])=C([H])C5=C4C(=C([H])N5[H])C([H])([H])[C@@]3([H])N(C([H])([H])[H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C2N(C(=O)C(=O)C2=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=NN(C(=O)C(C2=C([H])C([H])=C(F)C([H])=C2[H])=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C(Cl)C([H])=C1[H] [H]N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[H])C2([H])[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C#N [H]C1=C([H])C([H])=C2C(=N1)[C@@]([H])(O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])O[C@]([H])(C2=C([H])C(Cl)=C([H])C([H])=C2C2=C(ON=C12)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2N([H])C2=C(C([H])=NN2C([H])([H])[H])C1([H])[H] C[C@@H]1CN(CCN1S(=O)(=O)C1=CC=C(C=C1)[C@](O)(C(N)=O)C(F)(F)F)C1=C(C=C(F)C=C1)C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]OC(=O)C([H])([H])C1=C([H])C(C2=C([H])C3=NC(N([H])[H])=C([H])C([H])=C3N2[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[S@@](=O)C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2N1[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C1=NC(=C([H])C(=O)N21)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C(C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] CN1CC[C@@H]([C@H](CCC[N+]23CCS[Re]22(=O)SCCN2CC3)C1)C1=CC=C(Cl)C=C1 [H]N([H])[C@]([H])(C(F)=C1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=NC(=NO1)C1=C([H])C([H])=C(C([H])=C1Cl)S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]O\N=C(\C1=C(O[H])C(Cl)=C(C([H])=C1[H])C1=C([H])C(F)=C(O[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C4=C(C(OC([H])([H])[H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC(=O)[C@]1([H])[C@]2([H])[C@@]1([H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]1([H])C1=C([H])C(OC([H])([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])=C(F)C(F)=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1S(=O)(=O)N([H])C(=O)C([H])([H])[H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])(F)F [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C(=O)N([H])N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]\C(=C1\SC2=NC3=C([H])C([H])=C([H])C([H])=C3N2C1=O)C1=C(N(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H] [H]OC1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C2C(=O)C([H])([H])C([H])([H])C2=C1[H] [H]N([H])C1=NC(=C([H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C2=C(O\C(=C(\[H])C3=C([H])N(C4=NC([H])=C([H])C(N5C([H])([H])[C@@]6([H])O[C@]([H])(C([H])([H])C6([H])[H])C5([H])[H])=C34)C([H])([H])[H])C2=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C(=O)OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]N(C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N([H])C([H])([H])C1=C([H])C(=C([H])C(N([H])C(=O)[C@]2([H])C([H])([H])C3=C([H])C(OC4=C([H])C([H])=NC(N([H])C(=O)C5([H])C([H])([H])C5([H])[H])=C4[H])=C([H])C([H])=C3C([H])([H])C2([H])[H])=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1Br)C(=O)C([H])([H])Br [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C2S[C@@]([H])(C([H])([H])[H])C([H])([H])C3=C2C(=C([H])C([H])=C3OC([H])([H])C2=C([H])C([H])=C(C#N)C([H])=N2)N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C([H])C([H])=C1C(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]4([H])N(C(=O)C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]1([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]ON([H])C(=O)[C@@]([H])(SC([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)[C@]([H])(N2C(=S)S\C(=C(/[H])C3=C([H])C([H])=C([H])S3)C2=O)C([H])([H])[H])C([H])=C([H])C(O[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])[S@@](=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C(=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C(=C1[H])C([H])([H])[H])N([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H])C1=C([H])N=C(N=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N2C(=O)N([H])C3=C2C([H])=C([H])C(Br)=C3[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C(=O)N1C([H])([H])C([H])([H])C(C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(Cl)C(F)=C([H])C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=NN1C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H] [H]\C(=C(\[H])C([H])([H])[H])C(=O)OC([H])([H])[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@]2([H])[C@@]3(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@]3([H])C([H])([H])C([H])([H])[C@@]12C([H])([H])[H])C1=C([H])OC([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN=C(O1)C([H])([H])SC([H])([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=NOC(=N1)C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])=C([H])C(=C2[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])=C2C(=N1)N(C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)OC([H])([H])C1=C([H])C(=C([H])C2=C1OC([H])([H])OC2([H])[H])[N+]([O-])=O)C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])C(F)(F)F [H]N(C(=O)OC([H])([H])[H])C([H])([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C(=O)C1=NC([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(F)=C2[H])N1C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C2OC([H])([H])C([H])([H])N(C2=C([H])C(SC([H])([H])[H])=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C2C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C(C2=O)=C34)C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(\C([H])=C(/[H])C([H])([H])N([H])C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C(=N[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(=C2[H])[N+]([O-])=O)=C([H])C([H])=C1[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C(C([H])=C([H])S1)C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C1=NC(=C(N21)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)F)C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C2N=C(C([H])=C(N([H])[H])N2N=C1[H])[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C(N3C([H])([H])C([H])([H])N(C([H])([H])C4=NOC(=C4[H])C([H])([H])[H])C([H])([H])C3([H])[H])C(Br)=C([H])N=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H] [H]N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])N3N=C(C([H])=C23)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H]ON=C1C2=C(C([H])=C([H])C(=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C1C([H])=C(C([H])=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2O\C(=C(\[H])C3=C([H])C(=C([H])C([H])=C3[H])C([H])([H])[H])C3=C(C([H])=C([H])[C@]4([H])N([H])C(C([H])=C(C([H])([H])[H])[C@]34[H])(C([H])([H])[H])C([H])([H])[H])C2=C1OC([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)N1C([H])([H])SC([H])([H])[C@@]1([H])C(=O)N1C([H])([H])SC([H])([H])C1([H])[H])C2([H])[H] [H]N(C1=NC(OC([H])([H])[H])=NC(=C1[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H] [H]N(C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C(F)=C2[H])C([H])([H])C1([H])[H] [H][C@@]12CC3CC(C3(C)C)[C@]1(C)OB(O2)[C@H](CCCN1N=CN=C1[N+]([O-])=O)NC(=O)C1CCCN1C(=O)[C@@H](CC1=CC=CC=C1)NC(C)=O [H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C([H])C([H])=C3[H])[S@+]([O-])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] CC1=CC=C(F)C=C1NC1=NC2=C(O1)C(F)=C(CC(=O)N1[C@H](CO)CC[C@H]1CO[C@H]1CC[C@@H](CC1)C(O)=O)C=C2 [H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C([H])C(=C([H])C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=NC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C3C([H])=C(OC4=C(C#N)C([H])=C([H])C(=C4[H])C([H])([H])N4C([H])=NC([H])=C4C([H])([H])C(=O)N([H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C([H])C3=C([H])C([H])=C2[H] [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C(=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[N+]([H])([H])[H] [H]C(C1=C(N(C(=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])=C1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]N(C1=N[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C(C(=O)OC([H])([H])[H])=C(N1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C(OC([H])([H])[H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)OC([H])([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]1([H])[C@@]([H])(C(=O)O[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] Cc1ccc(cc1)C1CN(CC=C)CCc2c(Br)c(O)c(O)cc12 [H]SC1=NN2C(S1)=NN=C2C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2C(N([H])N=C2S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N1N=C([H])C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C(=C([H])C([H])=C12)C(F)(F)F)C([H])([H])C1=NC2=C(S1)C([H])=C([H])C([H])=C2[H] CC1=CC=CC=C1C1=CC=C(O[C@@H](CC2=CC=CC=C2)C(O)=O)C=C1 [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=O)C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=C(\OC(=O)C([H])([H])[H])C(F)(F)F)\C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@](C([H])([H])C#C[H])(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(Cl)C([H])=C(F)C([H])=C1[H])C1=C([H])C2=C(N([H])C([H])([H])N2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=O)N([H])C(=O)C(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Br)=C([H])S1)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(Br)=C1[H] [H]N([H])C1=NC([H])=C(C(=N1)N([H])[H])C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=O)N(SC2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(F)=C([H])C(OC2=C([H])N=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=NC2=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(Br)=C(O1)C1=NC(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OP(=O)(O[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C#CC([H])([H])OC1=C([H])C([H])=C2N(C(=O)N=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C2=C([H])C([H])=C(C([H])=C2N=C1Cl)C([H])([H])[H])C(=O)C1=C(Cl)SC(Cl)=C1[H] [H]N(C1=C2C(SC3=C2C([H])=C([H])N(C3=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2F)=NC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])SC([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N=[N+]=[N-])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C(C2=C([H])C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]N([H])C(=O)C([H])([H])S(=O)(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C(F)C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]\C(C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(Cl)=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=[N+]2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])O[H])C([H])([H])C([H])([H])[C@@]1([H])[C@](O2)(C([H])([H])[H])C([H])([H])O[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] CCCCC1=CC=C(C=C1)C1=CC=C2CN(C(=O)C2=N1)C1=CC=C(OCCN2CCCC2)C(OC)=C1 [H]OC([H])([H])[C@@]1([H])N(C2=NC(=NC(N([H])C(=O)C([H])([H])[H])=C2[H])N2N=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1(N([H])C(=O)C2=C([H])C3=C(N(C2=O)C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]2(O[C@]([H])(OC([H])([H])[H])C([H])([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C([H])C(=C([H])C2=C1[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(O2)(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C(Cl)C2=C(C([H])=NC([H])=C2[H])C([H])=C1[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])[C@]1(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N=C2C(=C1[H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C1=NN(N=N1)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C(F)(F)F [H]N([H])C(C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C2(C3=C(C([H])=C([H])C([H])=C3[H])N(C2([H])[H])S(=O)(=O)C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])SC([H])([H])[C@]3([H])N([H])C(=O)N([H])[C@]23[H])C([H])([H])C1([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H] COC1=CC2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CN=CC(CC(C)=O)=C3)C2=O)C=C1 [H]N1C2=C([H])C3=NC(=C([H])C(=C3C([H])=C2C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C(F)(F)F)N(S(=O)(=O)C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]N(C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]O[P@@](=O)(C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([O-])=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[N+]([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C(N([H])C2=NC([H])([H])[C@@]([H])(O[H])C([H])([H])N2[H])=C([H])C(N([H])[H])=C1[H])C1=C([H])C(Cl)=C([H])C(I)=C1O[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] CC(=O)N1N=C(CC1C1=CC=CC=C1)C1=CC2=C(Br)C=CC=C2OC1=O [H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=NC(C#N)=C4[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])N=C2N([H])C(=O)N(C2=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])OC(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C(C#N)C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OP(=O)(O[H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Br)=C1[H] [H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C(N([H])C1=O)(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=NC2=C1C([H])=C1C(=C2[H])C([H])([H])[C@]2([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])[C@@]2([H])C([H])([H])[H] [H]\C(SC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])=C(\[H])/C(/[H])=C(/[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C1=NC(=C([H])N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC(N([H])[H])=C2C(Cl)=C(N([H])C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])C([H])=C([H])C2=N1 [H]OC1=C(F)C([H])=C(C([H])=C1[H])C1=NN(C2=C1C(=NC([H])=N2)N([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C(=C2C(=O)N1C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NSN=C23)C([H])=C(Cl)C([H])=C1[H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])C#CC1=C([H])C2=C(C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])N([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])N=C2[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])=C(C2=C([H])C([H])=C(OC([H])([H])[H])N=C12)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]S\C(=N\C1=C([H])C([H])=C(C([H])=C1[H])C1=[N+]([O-])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(C2=C([H])C(OC3=C([H])C([H])=C([H])C(=C3[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H])=C2C([H])=C([H])C([H])=C(C2=N1)C(F)(F)F