[H]OC(=O)C([H])([H])C([H])([H])C(=N\OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O\N=C(\C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N=C(SC([H])([H])[H])N=C1N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=NC(=N1)N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C1=C2C(OC3([H])C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C2=NC([H])=N1)C1=C([H])C(OC([H])([H])[H])=NC([H])=C1Cl [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(C#N)=C([H])C(=C2O1)C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])[C@@]([H])(S[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)N([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])N2C3=C([H])C([H])=C([H])C([H])=C3N=C2C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)N(C2=NN(C([H])=C2[H])C2=C3C(=NC(=C2[H])C([H])([H])[H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]OC1=NSC(N([H])C2=C([H])C(Cl)=C([H])C([H])=C2Cl)=C1C#N COC(=O)N1CCN(CCCN(CCC(C2=CC=CC=C2)C2=CC=CC=C2)C(=O)NC2=CC=CC(=C2)C(=O)OC)CC1 [H]N(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C(C2=NC([H])=NN2[H])C(C#N)=C([H])S1 [H]C1=C([H])C([H])=C2N=C(OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(N4C(=O)OC([H])([H])C4([H])[H])C([H])([H])C3([H])[H])SC2=C1[H] [H]OC(=O)C1=C([H])C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C3([H])[H])=C([H])C([H])=C1Cl [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[H] [H]OC1(C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(C#N)(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])SC2=NC3=C(C4=C(S3)C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C(=O)N2C([H])([H])C([H])=C([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C2=C([H])OC([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C#N)C([H])([H])C1([H])[H])C1=C([H])C(=C(Br)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1([H])C2=C(OC([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C1=C2OC2(OC([H])([H])[H])C([H])(OC([H])([H])[H])C(=O)C3=C(OC([H])(C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])OC([H])([H])[H])C12OC([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])[C@]1([H])C(=O)C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N([H])[H])[C@@]([H])(N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C1=NC(=NC(N2C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]O[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])[H])[C@@]1([H])N(C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N(C(=O)[C@@]([H])(N(C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=N\C(=C(\[H])C2=C([H])N([H])C3=NC([H])=C([H])C([H])=C23)C(=O)N1[H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1O[H])S(=O)(=O)N([H])C([H])([H])C1=NC([H])=C(C([H])=N1)C(=O)N([H])[C@]([H])(C([H])=O)C(=O)O[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([N+]2=C(C(\C([H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C3=NC(=C(S3)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H] [H]N(C(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N=C1OC(=NC2=C1C1=NC3=C([H])C([H])=C([H])C([H])=C3N=C1N2C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]\C(=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C(OC2=NC([H])=C([H])C([H])=C2C2=NC([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H] [H]N1C([H])=C2C(=C1\C([H])=C1/C(=O)N([H])C3=C([H])C(=C([H])C([H])=C13)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C2=O [H]N1N=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C([H])N=C12)C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]\C(C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])=C1/C(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C(S1)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1C([H])([H])[H])C1=C(C#N)C([H])=NC(=C1\C([H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C2=C(S1)N(C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(N=C1[H])C1=C(F)C([H])=C(O[H])C([H])=C1F [H]O[C@@]([H])(C(=O)OC([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])N1C2=C(C([H])=C(C#N)C([H])=C2[H])C([H])([H])N([C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])[H] [H]OC1=C2C(OC(C3=C2C([H])=C(C([H])=C3[H])C([H])([H])O[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C1(C#N)C([H])([H])C1([H])[H] OC(C1=CN=C(S1)N1CCC(CC1)(C(=O)NCC(F)(F)F)C1=CC=CC=C1)(C(F)(F)F)C(F)(F)F [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(Cl)=C([H])C2=C1N(C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1(N([H])C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])=O)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl CC(=O)NCC1CCN(CC1)C1=C2SC(=CC2=NC=N1)C(N)=O [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]([H])(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])SC(=N1)C([H])([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]N(C1=NN=C([H])N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C(N=C([H])C([H])=C1[H])C1=C([H])SC([H])=C1[H] [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NN([H])C2=C1C(=NC([H])=C2[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=C([H])C([H])=C2F)C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C(C([H])([H])C(=O)N([H])C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)=C([H])C([H])=C1[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])SC([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(OC1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@@]([H])(OC([H])([H])C1=C(N=C(C#N)C([H])=C1[H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(C1=NN=C(O1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=NC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2S1 [H]N([C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(F)C(F)=C(F)C(F)=C2F)C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C1=C([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N(N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@]([H])(C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C1([H])[H] OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)C1=CC(CC2=NN=C(S2)C2=CC=CC=C2)=CC=C1 [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])OC1=C([H])C([H])=C(Br)C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(N=C1OC1=C([H])C2=C(C([H])=C([H])N2[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])N=C([H])N1C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])C2=C3C(OC([H])([H])C3([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)[C@@]1([H])C2=C(N(C(=O)C([H])=C2[H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(S[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]C1=C([H])C(=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])N([C@]([H])(C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])C4=C([H])C5=C(OC([H])([H])O5)C([H])=C4[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C1=C([H])C([H])=C([H])C(C(=O)OC([H])([H])[H])=C1N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC(=NC2=C1C([H])([H])C([H])([H])N(C1=NC([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C2([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2C([H])=C([H])C(=C([H])C2=C1[H])C([H])([H])N(C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C(SC2=C([H])C(F)=C([H])C([H])=C2[H])N=C1[H] [H]N(C1=NC([H])=C2N(C(=O)N(C2=N1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C(=O)C2=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])N(C([H])(C3=C(Cl)C([H])=C([H])C([H])=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] CN1N=C(CC(=O)NC2=CC=C(Br)C(Cl)=C2)C2=CC=CC=C2C1=O [H]C(=O)C1=C2N(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H]