[H]N(C1=NC(=C([H])S1)C([H])([H])[H])C1=NC([H])=NC2=C([H])C([H])=C(OC3=C(F)C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])[C@](C3=NN=C4N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])Cl)C1=C([H])C(=C(S1)C1=NN=C2S\C(=C(\[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=NN12)C1=C([H])C(F)=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N2C([H])=NC(=C2C([H])([H])N2C(=O)C(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]ON(C(=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C#CC1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C([H])C(=N1)C([H])([H])SC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)O[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1N=C(C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C12 [H]N(C(=O)C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C(=N1)N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(C1=C([H])C(F)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C(N=C(C([H])=C1[H])C(F)(F)F)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C([H])N(N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C1=C(F)C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]OC(=O)C1=NN2C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[C@@]2([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N([H])C1=C([H])C(=NN1C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NC(=NC([H])=C1[H])N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Br)C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(C(=O)N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@]1([H])O[C@@]([H])(N2N=C(C3=C2N=C([H])N=C3N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C(N([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])C(=C(N3C([H])([H])[H])C2=C([H])C([H])=C(Cl)C([H])=N2)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C(Cl)N(C2=NC(=C(N12)C([H])([H])N(C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(O2)C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(Cl)=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1\N=C1/SC(=NN1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(I)=C(OC2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]([H])(C([H])([H])OP(=O)(OC([H])([H])[H])OC([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=N1)C(=O)N([H])C1=C(Cl)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C1=NC(=NO1)C1=C(Cl)C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]O[C@]1([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2[H])C2=NC3=NC([H])=NC(N([H])[H])=C3C(=C2[H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C#N [H]OC(=O)C1=C([H])C([H])=C([H])N1[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC(Cl)=C1C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C(=O)C2=NC([H])=C([H])N2[H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C(Cl)=C(F)C([H])=C2[H])[C@]2([H])C([H])([H])C([H])([H])[C@]3(C4=C([H])C([H])=C([H])C(C#N)=C4[H])C([H])([H])[C@]23[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C#C[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])C(C(=O)N([H])C([H])([H])C([H])([H])C(=O)N([H])[H])(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])N1N=NC(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C#C[H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])N1N=NC(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C#C[H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]O[C@]1([H])[C@]2([H])C([H])([H])[C@]2([H])[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])[C@@]([H])(C([H])([H])C2([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])[C@]1([H])O[H] [H]N(\C([H])=C1/C(=O)N([H])C2=C([H])C([H])=C3N=C([H])SC3=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])[H] [H]N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C3C4=C(C#N)C(=O)N=C4C4=C3C2=C([H])C([H])=C4[H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(C#N)C(=C2[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])C([H])=C([H])O2)[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)[C@@]([H])(OC1=C(C#N)C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C2N(C3=NC([H])=C([H])C([H])=C13)C([H])([H])[C@]([H])(N(C(=O)[C@]1(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@]1([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]C1=C(C2=NSC(=N2)C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C2N1C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]1(N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])N([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])C(=O)C1=C(N(C(=N1)C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=N1)N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C([H])([H])C2=C(OC(F)(F)F)C([H])=C(Br)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)[C@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)C(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SSC1=NC([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]O\C(=C(\C#N)C(=O)N([H])C1=C([H])C([H])=C(OS(=O)(=O)C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N([C@]1([H])C(=O)N(C2=C(F)C([H])=C(C([H])=C2[H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)S1 [H]C1=C([H])N(C([H])=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2O[C@@]3([H])C([H])=C(N([H])[H])C(C#N)=C(N([H])[H])[C@@]3([H])[C@@]([H])(C2=C1[H])C([H])(C#N)C#N [H]N([H])C(=O)C1=C(SC2=C(C(C#N)=C(N=C12)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=NC([H])=NC(=C1[H])N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C([H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NOC(=N1)[C@@]12C([H])([H])C([H])([H])[C@@](C3=NN=C4N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C2=CC3=C(S2)C=CS3)C=C1 [H]OC(=O)[C@]1([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)N(C2=C(OC([H])([H])C([H])([H])C([H])([H])O[H])C([H])=C(Cl)C([H])=C2[C@]([H])(O[H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)C1=C([H])C2=C([H])C(=C([H])C([H])=C2N1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(\C([H])=N\OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC2=C(OC3=NC([H])=C(Cl)C([H])=C23)C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C1([H])[H] [H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])N(N=C1[H])C1=C([H])N=C(C([H])=C1[H])C(F)(F)F [H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] FC(F)(F)CCS(=O)(=O)OC1=CC=C(NC(=O)C2=C3C=CC=CC3=C(CN3C=CN=N3)C=C2)C(=N1)C(=O)NCC1CCOCC1 [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C(N([H])S(=O)(=O)C2=C(Cl)C(=C(Cl)C([H])=C2[H])C([H])([H])OC2=C3N=C(C([H])=C(C3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N=C1C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C(\[H])=N/OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(O[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C([H])=C2S1 [H]N([H])S(=O)(=O)C1=C([H])C(N([H])C2=NC3=C(C([H])=C(C([H])=C3N=N2)C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1N=C(C(=C1[H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])C([H])=C([H])C2=C1[H] [H]N(C(=O)C([H])([H])C#N)C1=C(Cl)C([H])=C([H])N=C1N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C1=NN=NN1C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])N2C([H])=C([H])N=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C3=NC([H])=NC(N([H])C4=NN([H])C(=C4[H])C([H])([H])C(=O)N([H])C4=C([H])C(OC([H])([H])[H])=C([H])C([H])=C4[H])=C3C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N=C(OC2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]1([H])O[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]O[C@@]12C([H])([H])C([H])([H])C([H])([H])[C@]3([H])OC4=C(C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H])C(=O)N([H])[H] [H]N(C1=NN=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C1[H])=C(S2)C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(OC([H])(F)F)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2(OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C(O[H])C(=C1[H])C([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C([H])=N1 [H]O[C@@]([H])(C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NN(C3=C([H])C([H])=C([H])C([H])=C13)C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(N([H])C(=N2)C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2F)=NC2=C1SC(=N2)N([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)N1[C@]([H])(C2=C([H])C(SC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N1C(=O)C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C(\C([H])=C(/[H])C(=O)C([H])([H])C(=O)C(\[H])=C(/[H])C2=C([H])C(OC([H])([H])[H])=C(O[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(F)C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])[C@]([H])(C(=O)O[H])[C@@]1([H])[C@]([H])(N([H])[H])C(=O)O[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=N/OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])\C([H])([H])[H])C1([H])[H] [H]ON(C(=O)N([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2O[C@]1([H])C([H])([H])[H]