CCOC(=O)C1=CC(NS(=O)(=O)C2=CC=C(Cl)C=C2)=CC=C1OC1=CC(Cl)=CN=C1
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(C([H])=C(Cl)N=C2C([H])=C1[H])C([H])([H])[H])C(=O)O[H]
[H]N1C([H])=C(C2=C1C([H])=C([H])C(C#N)=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])OC2=C([H])C([H])=C3C(C(=O)N([H])C3([H])[H])=C2C1([H])[H]
[H]N([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=C([H])N=C3C([H])=C([H])C(C#CC([H])([H])N([H])C(=O)C4=C([H])N=C([H])N(C4=O)C([H])([H])C4=C([H])C([H])=C(F)C(F)=C4[H])=C([H])C3=N2)C1([H])[H]
[H]OC1=C2C(=NC(=N1)N([H])[H])N([H])C(=C2SC1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])[H]
[H]N1C2=C(N=C1[C@@]1([H])N(C3=NC([H])=NC(=C3[H])N3C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N4C([H])([H])C5=C(C(=C([H])C([H])=C5[H])C5=C([H])N=C([H])C([H])=C5[H])C([H])([H])C4([H])[H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H]
[H]OC(=O)C([H])([H])OC1=C([H])C(OC2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C3([H])[H])=C([H])C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O
[H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C(N=C2N1C(=O)C(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])=C(N2C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(C(=O)OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)C2=C1C([H])=C([H])C(=C2[H])C([H])([H])OC1=C([H])C(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=NN([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N=C12
[H]OC1=C(C(=O)N(C2=C1C([H])=C(S2)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C1=C([H])C([H])=C([H])C([H])=C1[H]
OC[C@@H](NC(=O)c1cc(c[nH]1)-c1nc(Nc2ccccc2)ncc1C1CC1)c1ccccc1
[H]N([H])C1=C([H])C(=C([H])C(=N1)C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)N(C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(\C([H])=C2\N(\C(=N\C([H])([H])[H])N([H])C2=O)C([H])([H])[H])C2=C1C([H])=C([H])C(Br)=C2[H]
[H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
CC1=C(N(N=C1C(=O)NCCCCCNCCCCCNC(=O)C1=NN(C(=C1C)C1=CC=C(Cl)C=C1)C1=C(Cl)C=C(Cl)C=C1)C1=C(Cl)C=C(Cl)C=C1)C1=CC=C(Cl)C=C1
[H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H]
[H]N(N1C([H])([H])C([H])=C(C2=C([H])C([H])=C3N([H])C([H])=C(C3=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C(=S)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]N(C(=O)C1=C([H])N(C(=N1)C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])N=C2OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])=O)[C@@]3([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3(C2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=C(Br)C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(OC2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C2C(OC3(C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H]
[H]N(C1=NC(=C([H])C([H])=N1)C1=C2C([H])=C([H])C(=NN2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F
[H]OC([H])([H])C([H])([H])N(\N=C(/[H])C1=C2C([H])=C(C#N)C([H])=C([H])N2N=C1[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C1=NC(=O)C2=C(N1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H]
[H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[C@@]2([H])SC([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N([H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C3=C(N([H])C(=O)C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H]
[H]N([H])C1=NN=C(S1)C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=C([H])C(=C1Cl)C([H])([H])[H]
[H]ON(C([H])=O)[C@@]([H])(C([H])([H])N1C(=O)N(C([H])([H])[H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H]
[H]C1=C([H])C2=C(C([H])=C1[H])C(=NS2)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H]
[H]N1C2=NC(N([H])C3=C([H])C(=C([H])C([H])=C3N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C3=C(C([H])=C([H])C1=C3[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C(Cl)C([H])=N2
[H]N(C([H])([H])C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])N(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(C(=O)N2C([H])([H])C([H])([H])C([H])(N3C([H])([H])C([H])([H])C([H])(C([H])([H])C3([H])[H])C3(OC([H])([H])C([H])([H])O3)C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])C([H])([H])N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(N([H])C(=O)C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N1C(=S)N(C2=C1C([H])=C(F)C([H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H]
[H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=NN(C(=O)C([H])=C2[H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C([H])=C2Cl)C([H])([H])C1([H])[H]
[H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H]
[H]N=C1SC([H])([H])C([H])([H])N1C([H])([H])C1=C([H])SC(C(=O)N([H])C2=C(C([H])=C(Cl)C([H])=C2OC([H])([H])[H])C(=O)N([H])C2=NC([H])=C(Cl)C([H])=C2[H])=C1Cl
[H]N([H])C1=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])[H])C1=NC(=C([H])C([H])=N1)C1=C([H])C2=C(N1[H])C([H])([H])C([H])([H])N([H])C2=O
[H]N(C(=O)C1=C([H])C([H])=C(F)C(F)=C1[H])[C@]([H])(C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])O[H]
[H]N1C([H])([H])[C@]2([H])N(C3=C(C([H])=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(=O)N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]1([H])C([H])([H])[H]
[H]N(C(=O)OC1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H]
[H]N1C([H])([H])C2=C(Cl)C(Cl)=C(Cl)C([H])=C2C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])N(C(=C([H])C1=O)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NN(C(OC([H])([H])C(=O)N2C([H])([H])C([H])(C(=O)N([H])C3([H])C([H])([H])C([H])([H])C3([H])[H])C2([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)O1)S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H]
[H]N([H])C1=N[C@@]([H])(C([H])([H])C([H])([H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C(N([H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]O[C@@]1([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2F)N2C([H])=C([H])C([H])=C([H])C2=O)C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(Cl)S1
[H]N(C(=O)C(\[H])=C(\[H])C1=C([H])N(N=C1C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2C1([H])[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N1C(=O)C2=C3C(N([H])C4=C3C([H])=C(C([H])=C4[H])C3=C([H])SC(=N3)C([H])([H])S(=O)(=O)C([H])([H])[H])=C3C(=C2C1=O)C([H])([H])C([H])([H])C3([H])[H]
[H]C1=NC([H])=C([H])C(=C1[H])C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C([H])=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=NN([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
CCCCN1C(=O)C(=O)C2=CC(=CC=C12)S(=O)(=O)N1CCC[C@H]1COCC
[H]OC(=O)[C@]([H])(C1=C([H])C([H])=C(C(F)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1(C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[P@@]1(=O)OC([H])([H])[C@]([H])(N([H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])O1)C([H])([H])C(F)(F)F
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H]
[H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C(N(C2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C12)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)[C@]12O[C@@](O[C@]([H])(C3=NN=NN3C([H])([H])[H])[C@@]1(O[H])C(=O)O[H])(C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(C(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])[C@@]2([H])O[H]
[H]N(\C(SC([H])([H])C1=C([H])S\C(=N\C([H])([H])[H])N1C([H])([H])[H])=N\C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])[C@@]([H])(O[H])C([H])=C([H])[C@@]4([H])[C@]([H])(N(C([H])=O)C([H])([H])C([H])([H])[C@]314)C2([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N1C([H])=C([H])N=C1C1(C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)C3=C(C(=NN3C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C2([H])[H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC([H])=C(C2=C1C(=C([H])S2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3[H])C3=NC(OC([H])([H])[H])=C([H])S3)C([H])=C2C([H])([H])C1([H])[H]
[H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H]
CCCCCN1C=C(C(=O)NC23CC4CC(CC(C4)C2)C3)C2=CC(=CC=C12)C1=CC=CC=C1
[H]C(=O)[C@]1([H])C([H])([H])[C@]([H])(OC(=O)C([H])([H])[H])C(=O)[C@@]2([H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[C@]([H])(C3=C([H])OC([H])=C3[H])C([H])([H])[C@]21C([H])([H])[H]
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C([H])([H])C1([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])N=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C(N(C(=C1C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])O[N+]([O-])=O)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H]
[H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(F)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)C1=NN(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(OC2=C([H])C(Cl)=C(C#N)C([H])=C2[H])C1(C([H])([H])[H])C([H])([H])[H]
[H]N([H])C1=NC(=NN1C(=O)C1=C(F)C([H])=C([H])C([H])=C1F)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1
[H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])N=C(Cl)C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C1[H]
[H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C3=C([H])C(=C([H])C(Br)=C3N2C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N1C2=C([H])C([H])=C(C([H])=C2N=C1C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]ON([H])C(=O)[C@]([H])(OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]C1=NN2C([H])=C(C([H])=NC2=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H]
[H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C1(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C(=O)N([H])[H]
[H]N1[C@@]2([H])C(C(=O)N(C([H])([H])C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C3([H])C([H])([H])C3([H])[H])=C(C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])OC3=C(Cl)C([H])=C(C([H])=C3Cl)C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)C([H])([H])[H])C2([H])[H]
[H]O[C@@]([H])(C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H]
[H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])=C([H])C([H])=C1[H]
[H]N([H])C1=C(C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C(=O)N([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])[H]
[H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC(F)(F)F)C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1=C(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(\C(N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C(\C#N)C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1N([H])C([H])=C2Cl
[H]C1=C([H])C([H])=C(C(=C1[H])C1=NC(=C(O1)C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C([H])=C(OC([H])([H])[H])N=C2N2C(=NC(=C12)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
CNC1=NC(C)=C(S1)C1=C(O)C=NC(NC2=CC=CC(=C2)S(N)(=O)=O)=N1
[H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H]
[H]C1=C(C(=NN1C1=NC([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H]
[H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C1C([H])=C(C([H])=C2[H])C1=C2N(N=C1C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H]
[H]C1=C([H])C([H])=C2N=C(OC2=C1[H])SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C1=C(C(=O)C([H])([H])OC(=O)C2=C([H])C(=NC3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])O2)C(=O)N(C(=O)N1C([H])([H])[H])C([H])([H])[H]
[H]N(C([H])([H])C(=O)N1C([H])([H])[C@@]([H])(F)C([H])([H])[C@@]1([H])C#N)[C@@]1([H])[C@]2([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[C@]12[H]
[H]ON1C2=C(C(=NN2C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12
[H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H]
[H]N1C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H]
[H]N(N([H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(C(=O)O[H])C(=O)N([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O[H]
[H]OC1=C([H])C([H])=C(C([H])=C1[H])N1N=C2N(C1=O)C1=C(N=C2N([H])[H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C(C#N)=C(C([H])=C1N1C(=O)N(C([H])([H])C([H])([H])OC([H])([H])[H])C(C1=O)(C([H])([H])[H])C([H])([H])[H])C(F)(F)F
[H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N1C(=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C([H])S1
[H]N(C(=O)C1=C([H])C2=C(C([H])=C(N2[H])C2=NN([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])[H]
OC(=O)C[C@@H]1C[C@@H]([C@H](N(CC2CC2)C1=O)C1=CC=C(Cl)C=C1)C1=CC=CC(Cl)=C1
[H]OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=NN([H])C3=C2C(=NC([H])=N3)N([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C(Cl)=C2[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])[C@]([H])(C2=C(Cl)C([H])=C([H])C([H])=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H]
[H]C1=NC([H])=C(OC([H])([H])[H])C([H])=C1C1=C([H])C2=C(C([H])=C1[H])N(C(=O)C([H])([H])C2([H])[H])C([H])([H])[H]
[H]N(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C(=NC([H])=N1)N1C([H])([H])C([H])([H])C([H])(C2=NC(=NO2)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])[N+]([O-])=O
[H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C2N([H])S(=O)(=O)C2=C([H])C([H])=C(Cl)C(=C2[H])C(F)(F)F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C2C(=C1OC([H])([H])[H])[C@@]13C([H])([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]1(O[H])[C@]([H])(N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C3([H])[H])C2([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(Cl)C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NC(=C([H])O1)C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C(Cl)C(=C([H])S1)C([H])([H])N1N=NC([H])=C1[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C(=O)[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1=C([H])C(O[H])=C2C(OC(=O)C(N3C([H])([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])=C2C([H])([H])[H])=C1[H]
[H]C1=C(SC2=NC(=C(C(=O)OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N12)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl
[H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C([H])=C([H])C([H])([H])C1=C(N([H])C2=NC([H])=C([H])N=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=NC(=C(O1)C1=C([H])N2C(=NN=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C1=C(F)C([H])=C([H])C(F)=C1[H]
[H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C3=C(N=C(N3[H])C3=NN([H])C4=NC([H])=C(C([H])=C34)C3=C([H])N=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1(C2=C(F)C([H])=C([H])C([H])=N2)C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])N(N=N1)C([H])([H])[H]
[H]N=C(N([H])C([H])([H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1
[H]N(C(=O)C1=C([H])C2=C(N=C(N2C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C2=NN=NN2[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]N(C(=O)C1=C([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C(=O)OC3=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]N(C1=NC2=C(N=C(S2)C2=C([H])C([H])=C([H])C(=C2[H])[C@@]([H])(N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=NC2=C(S1)C1=C(SC(=N1)C([H])([H])[H])C([H])=C2[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C(C(=O)C2=C([H])C([H])=C([H])C([H])=C2O1)C([H])([H])C1=C(O[H])OC2=C([H])C([H])=C([H])C([H])=C2C1=O
[H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C([H])([H])Cl)C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C(=N\OC([H])([H])[H])\C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H]
[H]ON([H])C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C#N)N1C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C([H])C(=C(C([H])=C2N=N1)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])N=C(Cl)C([H])=C1[H])C2([H])[H]
[H]N(N1C2=C([H])C([H])=C([H])C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C(Cl)=C2[H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
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[H]N1C([H])=C([H])C2=C1N=C([H])N=C2N1C2=C(C([H])=C([H])C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H]
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[H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])[C@]4([H])N([H])C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C1=C(C([H])=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F
[H]OC1=C(SC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H]
[H]N(C1=NC2=C(C([H])=N1)C([H])=C([H])C(OC([H])([H])[H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])C([H])([H])N2[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(N2C(=NC4=C2C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C3([H])[H])C([H])([H])C([H])([H])N(\C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=N/C#N)C([H])([H])C1([H])[H]
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[H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=NN1[H])C1=C([H])N=C2C(=N1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H]
[H]N([H])C(=O)N([H])C1=C(C([H])=C(S1)C#CC1=C([H])SC([H])=C1[H])C(=O)N([H])[H]
[H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=NC([H])=C([H])C([H])=C1[H]
[H]N([H])C1(C([H])([H])C2=C(Cl)C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H]
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[H]N=C(N([H])[H])C1=C([H])C([H])=C(\C([H])=C2/C(=O)/C(=C(\[H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C2([H])[H])C([H])=C1[H]
[H]N(N1C(SC([H])([H])SC2=NN=C(N2N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(SC3=C2C([H])([H])C([H])([H])C([H])([H])C3([H])[H])N([H])C(=O)C([H])([H])[H])=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H]
[O-]C(=O)C(F)(F)F.CC1=NC2=C(OCC3=C(Cl)C=CC(=C3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCC(CNCCCC[N+](C)(C)C)CC3)C=CC=C2C(C)=C1
[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H]
[H]N(C1=NN=C(O1)C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C2C(=NC(=N1)C([H])([H])[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H]
[H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C1=C(O[H])C(F)=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H]
[H]N(C1=C(N=C2C([H])=C([H])C(Cl)=C([H])N12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(SC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(\C(=N/C([H])([H])[H])N1N=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl
[H]C1=C([H])C([H])=C2C([H])=C(C([H])=C(C2=N1)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C#N
[H]OC(=O)C([H])([H])N([H])C(=O)[C@]1([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C(Cl)=C1Cl
[H]OC1=C(C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(O1)C(\[H])=C1\S\C(=N/C2=C([H])C([H])=C([H])C([H])=C2[H])N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([O-])=O
[H]N([H])S(=O)(=O)C1=C([H])C(F)=C(N([H])C(=S)N([H])C([H])([H])[C@]23OC(O[C@@]2([H])[C@]2([H])OC(O[C@]2([H])C([H])([H])O3)(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(C#N)C(=N\C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])\N1C([H])([H])C([H])([H])C(=C2C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H]
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[H]N([H])C(\SC([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])N1[H])=N/C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]N(C1=NC([H])=C2C([H])=C(C(=O)N(C2=N1)C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C(=O)N(C([H])([H])C1=NC(=NO1)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C1(C#N)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC([H])([H])[C@@]([H])(OC([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N1[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C2=C([H])C([H])([H])[N+](=C(N([H])[H])N([H])[H])C2([H])[H])C([H])([H])[C@]2([H])C([H])([H])[C@]([H])(O[H])[C@@]([H])(O[H])C([H])([H])[C@]12[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=N1)C1=NC([H])=C([H])N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]OC(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])[C@@]1([H])ON=C(C2=C([H])C([H])=C(C([H])=C2[H])C(=N[H])N([H])[H])C1([H])[H]
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[H]ON([H])C(=O)C1=C(N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C(\[H])=C(/[H])C1=C2C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C([H])([H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O
[H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]C([H])([H])C1=C(C(=O)ON1C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C([H])C([H])=NN2C(N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])=C1C([H])([H])[H]
[H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1OC1=NC([H])=C(C([H])=C1Cl)C(F)(F)F)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]N(C(=O)C1=C([H])C(=C([H])N=C1[H])C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
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[H]C1=C([H])N(C(=N1)C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C(Cl)C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C(=O)ON=C1C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C(S2)C([H])([H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])C(=N\OC([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H]
[H]C1=C(N2N=NC3=C2N=C(N=C3N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(Br)=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
CC1=CC(Cl)=C(OCCOC2=CC=C(CC(CN)C3=CC=C(C=C3)C3=C(Cl)C=CC=C3)C=C2)C(Cl)=C1
[H]OC1=C(F)C(=C([H])C([H])=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(Cl)=C([H])N=C(N([H])C([H])([H])C(F)(F)C2=NC([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C(OC2=C(C([H])=C([H])C([H])=N2)C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
[H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C(=C(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C4(C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])N(C(=O)C5([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C5([H])[H])C4([H])[H])C([H])([H])[C@@]3([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
OC1=C2C(=O)C=C(OC2=CC(OCOC(=O)CCON(O)=O)=C1)C1=CC=CC=C1
[H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(OC([H])([H])[H])C(=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])N([H])N=C1[H]
[H]OC([H])([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])[H])C([H])=C([H])C(I)=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NN=C(O1)C([H])([H])[H]
[H]N(C1=NC2=C(N1[H])C([H])=C([H])C(=C2[H])N1C([H])=NC2=C(SC(=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H]
[H]OS(=O)(=O)C([H])([H])C([H])([H])[C@](N([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H]
[H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NC(=O)C(N1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H]
[H]N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C(C(=NC([H])=N2)N2C([H])([H])C([H])([H])C([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])[N+]([O-])=O)C([H])=C1[H]
[H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)[C@]([H])(C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]OC(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C([H])(OC2=C(Br)C([H])=C([H])C(F)=C2[H])C([H])([H])C1([H])[H]
[H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C([H])=C(C1=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1F)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1SC([H])([H])[H]
[H]N(C1=C([H])C(OC([H])([H])[H])=C2N=NN(C2=N1)C1=C([H])C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12
[H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=NC([H])=C(S2)C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C1=C(C2=C([H])C(=C([H])C([H])=C2N1C1=C([H])C([H])=C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H]
[H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H]
[H]C1=C([H])C(\N=C2/SC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N2C(=S)SC([H])([H])[H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]N(\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H])C(=O)C([H])([H])C1=C([H])SC(=N1)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F
[H]C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C(N=N1)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C2=O
[H]N1C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC(=C1C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H]
[H]O[C@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C(=C3N=C2[H])C([H])([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C2=C(C([H])=C1Cl)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]2([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H]
[H]N1C([H])([H])[C@@]2([H])N(C3=C(C(Cl)=C([H])C([H])=C3C2([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H]
[H]N([H])C(=O)[C@]([H])(SC1=NC2=C(C([H])=NN2C2=C([H])C([H])=C([H])C([H])=C2[H])C(SC([H])([H])[H])=N1)C([H])([H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C(N([H])C([H])=C2[H])C([H])=N1
[H]C1=NC(=C(O1)C1=NN=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3(C3=C([H])C([H])=C(Cl)C([H])=C3F)C2([H])[H])N1C([H])([H])[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N2C(=NC(Cl)=C2[C@@]([H])(N2C(=O)C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]OC(=O)[C@](OC([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])OC1=C([H])C(=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])N(C(=O)[C@@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC2=C(Cl)C([H])=C(C([H])=C2Cl)C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C1([H])[H]
[H]O[C@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@](OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C2=C([H])[C@@]3([H])[C@@]4([H])OC([H])([H])O[C@@]4(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@]3(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]3([H])C([H])=C(C(=O)[C@@]3(O[H])C2([H])[H])C([H])([H])[H])C([H])=C1OC([H])([H])[H]
[H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C#N)C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H]
[H]N([H])S(=O)(=O)[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@]([H])(N([H])C(=O)C(OC1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F)(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C3([H])[H])C2([H])[H]
[H]N([H])S(=O)(=O)N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C(C#N)C([H])=C12)C1=C([H])C([H])=C(F)C([H])=C1[H]
[H]OC([H])([H])C([H])([H])[C@@]([H])(N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H]
[H]N(C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])C([H])([H])[H]
[H]N([H])C1=C(OC2=NC(C3=C([H])C([H])=C(Cl)C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)N1C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]
[H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N(C([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N1[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(N([H])C([H])([H])C1([H])[H])=C(C#N)C#N
[H]OC1=NC2=C([H])C([H])=C(C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H]
[H]OC1=NC(=C(C2=C([H])C(=C3N=C(N([H])C4=C(Cl)C([H])=C([H])C([H])=C4Cl)N(C3=C12)C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H]
[H]OC([H])([H])C1=C([H])C([H])=C(C([H])=N1)C1=C2C(OC([H])([H])[C@@]([H])(N([H])C(=O)C3=C([H])N=C(OC([H])([H])C(F)(F)F)C([H])=C3[H])C2([H])[H])=C([H])C([H])=C1[H]
[H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])[H]
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[H]OC(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3(C(=C([H])C(=O)[C@]4([H])[C@@]5(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]5([H])C([H])([H])C([H])([H])[C@@]34C([H])([H])[H])[C@]2([H])C1([H])[H])C([H])([H])[H]
[H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C(=O)C2=C(O1)C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
[H]\C(=C1\[C@@]2([H])[C@@]([H])(OC(=O)[C@@]2([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H])C([H])([H])[H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1([H])[H]
[H]OC(=O)C([H])([H])[C@]([H])(O[H])C([H])([H])[C@]([H])(O[H])C([H])([H])OC1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H]
[H]N1N=NC(=N1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C(=O)C2=C1C([H])=C([H])C(=C2[H])C([H])([H])OC1=C([H])C(=NC(=C1C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H]
[H]N(C(=O)C([H])([H])[C@]1([H])N(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C([H])=C([H])C3=C([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC(=O)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]23[H])C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H]
[H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H]
[H]N(C1=NC2=C(N=C([H])N2C2=NN([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1Cl)[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H]
[H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H]
[H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
[H]C1=C([H])C2=C(S1)C([H])([H])[C@]([H])(OC([H])([H])[H])O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]
[H]N1C([H])=C(C2=C(C(=O)N([H])C2=O)C2=C3C([H])=C([H])C([H])=C([H])C3=NC(=N2)N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2Cl