[H]C1=C([H])N2N=C(N=C2C(=C1[H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2OC3=C(C2=C1[H])C(=C(OC([H])([H])C([H])([H])[H])C([H])=N3)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1Cl)C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C2N([H])[C@]([H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N2N=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F [H]\C(=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[N+]([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]2([H])C1=O)C(=O)OC([H])([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C([H])=C(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])[C@@]1([H])[C@@]([H])(O[H])C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N=[N+]=[N-])C([H])=C1O[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C(=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])O1)[N+]([O-])=O)C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(Br)=C([H])C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)O2)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C([H])=C1C([H])([H])[H])C([H])([H])C1=NC2=C(S1)C([H])=C([H])C(=C2[H])C(F)(F)F [H]N(C1=NC2=C(C([H])=N1)C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H])C([H])([H])[H] [H]N1C(=S)S\C(=C(\[H])C2=C([H])C3=C(OC([H])([H])C(=O)N3C([H])([H])C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3Cl)C([H])=C2[H])C1=O [H]O[C@]([H])(C(=O)N1C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]1([H])O[H])[C@@]([H])(N([H])C(=O)C([H])([H])OC1=C(C([H])=C(N([H])C([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C([H])N(C3=NN([H])C(=C3[H])C([H])([H])[H])C2=N1)[C@]([H])(C1=C([H])C([H])=C(F)C([H])=N1)C([H])([H])[H] [H]\C(=C(\[H])C1=[N+](C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2N1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])\C(\[H])=C1/N(C2=C([H])C([H])=C([H])C3=C2C1=C([H])C([H])=C3[H])C([H])([H])[H] [H]N(C(=O)O[C@]1([H])C(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1(C([H])([H])[H])C2([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)N(C2=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C5=C(C([H])=C([H])C([H])=C5[H])N4C([H])([H])C4=C([H])C(N=C=S)=C([H])C([H])=C4[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C2([H])C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])N=C([H])N2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=N3)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])[C@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=NN([H])C([H])=C2N([H])C(=O)C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[N+]1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C([H])C(F)=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C(OC(=N1)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[H] [H]OC1=C([H])C2=C(OC(=C2[H])C(=O)N([H])[C@@]2([H])[C@@]([H])([N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])([H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(OC([H])([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] OC1(CCN(C1)C1=CC(Cl)=C(C=C1)C#N)C1=CC=C(F)C=C1 [H]OC1=C([H])C([H])=C(N([H])C(=O)N([H])[C@@]2([H])C(=O)N(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(OC([H])([H])C2=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(C1=C2C([H])=C([H])C([H])=C1[H])=C1C(=O)N(C(=O)C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C2=C(N(C([H])=C2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C2=C1C(=NC([H])=N2)N([H])[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C3C(ON=C3C3=C([H])C([H])=C([H])C([H])=C3[H])=C2C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=O)C([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H] CN(C)C1=C2C=CC(=CC2=NC=C1C#N)C1=CC=C(C=C1)S(C)(=O)=O [H]N([H])C(=O)C1=C([H])N=C(N=C1N([H])C1([H])C([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1N=C([H])C2=C(C([H])=C([H])C(=C12)C([H])([H])[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])C2=NC(C#N)=C(O2)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1Cl [H]N1C([H])=C(C2=C1N=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NO2)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N1N=C(C2=C1C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(F)(F)F [H]N(C1=C([H])C(=NC(=N1)C([H])([H])[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])SC1=NN=C(N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])N1C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NN=C(O1)C1=C(C([H])=C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])=C1[H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])C([H])=C([H])N=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])OC1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(C(=O)N(C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C(N([H])C(=S)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])S[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C(=O)[C@@]([H])(N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]1([H])C2=C(C([H])=C(Br)C([H])=N2)C([H])([H])C([H])([H])C2=C1C([H])=C([H])C(Cl)=C2[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=NC([H])=NC(=N2)N([H])C([H])([H])C(F)(F)F)=C1[H] [H]N1C2=C(N=C([H])C([H])=C2[H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C3N([H])N=C(C3=C2[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C(Cl)C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1C([H])=NC2=C1N=C(N=C2[H])N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)C([H])([H])C1([H])[H] CCC(=O)NC1CCN(CCCN2C(=O)CCC3=C2C=CC=C3F)CC1 [H]OC1=C([H])C2=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])[C@]([H])(O2)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C1=NC([H])=C(Cl)C([H])=C1C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC([H])=C([H])N1[H] [H]N1C(=S)C(C#N)=C(C2=C([H])C([H])=C(O2)C([H])([H])[H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2O1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] COC1=CSC=C1C(=O)N1CCC(F)(CNCC2=NC=C(C)C=C2)CC1 [H]N(C(=O)N([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N([H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(=O)[C@@]([H])(O[H])C([H])([H])N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C(N1C(=O)N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])[H])\C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(C#N)=C2[H])N(C2=C1C([H])=C1C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] C\C(=N/OCC1=CC(=C(C=C1)C1=CC=CS1)C(F)(F)F)C1=CC=C(CNCCC(O)=O)C=C1 [H]OC(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C(OC(=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])=C2C3=C1C([H])=C([H])C([H])=C3N([H])C(=O)C2([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@@]1(C(=O)N([H])C3=C1C([H])=C([H])C([H])=N3)C2([H])[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(=O)C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O [H]OC([H])([H])C([H])([H])N([H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N([H])C1=C(C(Cl)=C([H])C([H])=C1[H])C([H])([H])[H] CN1N=C(NC(=O)NC2=CC(=C(CN3CCN(C)CC3)C=C2)C(F)(F)F)C=C1C#CC1=CN=C2C=NC=CN12 [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)C1=C(C(=C([H])C(=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(=NO1)C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])C([H])([H])C(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] COC1=CC(NC(=O)CSC2=NN=C(CNC3=C(C)C=CC=C3C)N2C)=C(OC)C=C1 [H]N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])N([H])C3=C2C([H])=C(C#N)C([H])=C3[H])C1([H])[H] [H]O[C@]1([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C4[C@]5([H])[C@@](O[H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]5(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C(C([H])([H])[H])(C([H])([H])[H])[C@@]1([H])O[H] [H]C([H])([H])C([H])([H])N(C([S-])=S)C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NC(Cl)=C2[H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(C#CC3=C([H])C([H])=C([H])C([H])=C3[H])=C(OC([H])([H])C#N)C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1=O [H]N(C(=O)[C@]1([H])S[C@@]([H])(N(C1=O)C([H])([H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C(Br)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N2C(=O)C([H])([H])N(C([H])([H])[C@]2([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NC(=C2N=NC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3N12)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC4=C([H])C([H])=C([H])C5=C4OC(=C([H])C5=O)C4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C(F)=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@]1([H])F [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])N(C(=C2C(=O)C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N1C2=C([H])C([H])=C([H])N=C2N(C(=O)C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C2=C(C([H])=C([H])C([H])=C2[H])C1=O [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C(Cl)C([H])=NC(=C3[H])N3C([H])([H])[C@]([H])(N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C3([H])[H])C([H])([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]\C(=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[S@@](=O)C1=NC([H])=C(O1)C1=C([H])OC([H])=N1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C([H])([H])C(=O)N([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C(=NC2=C1N(C(=O)[C@]([H])(C2=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1=O [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1Br)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]O[C@](C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(=C([H])N=C1Cl)C1=C([H])C([H])=C2N=C([H])C(=NC2=C1[H])N1C([H])([H])C([H])([H])C(F)(F)C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1=C(C([H])=O)C([H])([H])[C@]2([H])[C@@]3([H])C([H])([H])C([H])([H])C4=C([H])C(O[H])=C([H])C([H])=C4[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]N=C(SC([H])([H])C([H])([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])[C@](C3=C([H])C(O[H])=C([H])C([H])=C3[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[S@@](=O)C2([H])[H] ClC1=CC=C(C(Cl)=C1)S(=O)(=O)NC1=CC=C(OC2=CC(Cl)=CN=C2)C(=C1)C#N [H]N(C(=O)C([H])([H])OC1=C2C(N([H])C([H])=C2S(=O)(=O)C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]C1=C([H])C([H])=C2C([H])=C(C3=NN=C(N3C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3C(F)(F)F)C(Cl)=C([H])C2=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(C#N)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])(C2=NC3=C(OC4=C3C([H])=C(Br)C([H])=C4[H])C(=O)N2[H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2O1 [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=C([H])C(N([H])[H])=C1[H])C(=O)N([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C(=O)C([H])=C(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N1C(SC([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC(Cl)=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N(C(=O)C3([H])C4=C(C([H])=C([H])C([H])=C4[H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(C2=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])[H] OC(=O)C(F)(F)F.NC(=N)C1=CC=C(CNC(=O)[C@@H]2CC3=CC=C(NC(=O)CN4CCN(CC4)CC(=O)NC4=CC(C[C@@H](NS(=O)(=O)CC5=CC=CC=C5)C(=O)N2)=CC=C4)C=C3)C=C1 [H]OC(=O)C1=C([H])N(C2=C(C([H])=C(F)C(=N2)N2C([H])([H])[C@]([H])(N([H])[H])[C@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1=O)C1([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C(=C(N=C1[H])N1C([H])([H])C([H])([H])N(C2=NC3=C(C([H])=C(C([H])=C3N2[H])C(F)(F)F)C2=C([H])C(F)=C(F)C(F)=C2[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C(F)(F)F)C([H])([H])[H] [H]N1[C@]2([H])C3=C(N(C4=C([H])C([H])=C(C([H])=C34)S(=O)(=O)C3=C([H])N(C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H] [H]N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C#N)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[N+]([O-])=O)S(=O)(=O)N([H])C1=NC([H])=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1(N([H])C(=O)C([H])(F)F)C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C(=O)OC([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(N([H])P([O-])(=O)C([H])([H])N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])C([H])([H])C(=O)N1C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])=C([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])[C@](C2=C([H])C(O[H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C1=C([H])C([H])=C(F)N=C1[H])C1=C(OC([H])([H])[H])C(C#N)=C([H])C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(F)C(F)=C(F)C(F)=C2F)C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)C([H])([H])S(=O)(=O)C1=C([H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NOC(=C1[H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=C([H])C(C2=C([H])C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]C1=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])=C2C(=N1)C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])N=C2C([H])=C([H])C(=NN12)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])N(C(=O)C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(C2=C([H])C([H])=C(Br)C([H])=C2[H])=C(C([H])=N1)[C@]1([H])N(C(=O)C([H])([H])[S@]1=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])C1=C([H])C2=C(C([H])=C1[H])N(C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])S1 [H]OC1=C(C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C1=NN=C(O1)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C1C1=C([H])C(Cl)=C(N([H])C([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]OC(=O)[C@@]1([H])N([H])C2=C(C([H])=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])[C@@]2([H])C([H])=C([H])C([H])([H])[C@@]12[H] [H]N([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C(N=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] CS(=O)(=O)NC1=C2N=C(C=C(O)C2=CC=C1)C(=O)NC1=CC=C(F)C=C1O [H]N(C(=O)C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])=C(F)C([H])=C2F)S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1[H] [H]N(C(=O)C(\C#N)=C(/[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]OC1=C2N(C3=C(C2=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N(C1=NC(=C(S1)C([H])([H])N(C([H])([H])C([H])([H])C(F)(F)F)C([H])([H])C1([H])C([H])([H])C1([H])[H])C(F)(F)F)C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]N(C([H])([H])[H])[C@]1([H])C2=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O\C(=C(\C#N)C(=O)N([H])C1=C(Cl)C([H])=C(C([H])=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC1=C([H])C([H])=C2C(=O)N(C(=O)C2=C1[H])C([H])([H])[H] [H]C#CC([H])([H])N1C(=O)N(C2=C(N3C([H])=C([H])C([H])=C([H])C3=N2)C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C(O[H])=C([H])C([H])=C2C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])S2)C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C2=C1N([H])C1=C([H])C([H])=C([H])C([H])=C1O2 [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C(F)(F)F)N=C1[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1Cl [H]OC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C(O[H])(C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(N=N1)N1C([H])([H])C([H])([H])C([H])(OC2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N(C(=O)C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O [H]N(C(=O)C1=C([H])C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])C(\[H])=C(/[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NN(N=N1)C1=C([H])C(F)=C([H])C(=C1[H])C1=C(OC(F)(F)F)C([H])=C([H])C([H])=C1[H] [H]OC1=C(O[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])[C@]2([H])C([H])([H])OC1=C([H])C([H])=C2C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C([H])C2=C1[H] [H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])N=C1[H] [H]C1=C(OC(=N1)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=NC(=NC2=C1C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])N(C1=C([H])C(F)=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C#C[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])O[C@@]([H])(C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C(Cl)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1C2([H])[H] [H]N([H])C1=N[C@]([H])(C2=NC([H])=C([H])S2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C(C(=O)N([H])C2=NC([H])=C([H])S2)C(=NC2=C(C([H])=C([H])C([H])=C12)C(F)(F)F)C([H])(Cl)Cl [H]N1C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2C2=C(C([H])=NC3=C([H])C(=NN23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1=O [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=NN3C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=C23)C([H])([H])[H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C([H])C(=C([H])C([H])=C1C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(SC2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=O)C(C#N)=C(C([H])=C1C1=C([H])C(Br)=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F [H]N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H]