[H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)C([H])([H])O[C@@]1([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] CC(C)[Si](OCC1=CC=C(C=C1)C1=NC2=C(C=CC=C2N1)C(N)=O)(C(C)C)C(C)C [H]N(C(=O)C(F)(F)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C(N([H])C(=O)N(C2=C([H])C(=NC([H])=N2)N([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC([H])([H])[C@@]1(OC(=O)\C(=C(\[H])C2=C([H])C(F)=C(Cl)C([H])=C2[H])C1([H])[H])C([H])([H])OC(=O)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2C1=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])N(C(=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C4=C(C([H])=C3[H])C([H])([H])C([H])=N4)[C@@]1([H])C2([H])[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]1(OC(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@]1(OC([H])([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] CC1=CC=C(C=C1)C(=O)NCCCC(=O)N1CCC[C@H]1C(N)=O [H]OC(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C1([H])[H] [H]N(C(=O)OC1=C([H])C([H])=C2N(C([H])([H])[H])[C@]3([H])N(C([H])([H])C2=C1[H])C([H])([H])C([H])([H])C1=C3C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(\N=C1/C(=O)N([H])[C@]2([H])C([H])=C([H])C([H])=C([H])[C@]12[H])C(=O)C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H] [H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C([H])=C3[H])C1=C2C2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]C1=C(C2=C([H])C([H])=C([H])C([H])=C2N1C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=NC(=NC2=C1C([H])=NN2C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1S(=O)(=O)C([H])([H])[H])C(=O)OC([H])([H])[H])S(=O)(=O)C1=C(C2=C(S1)C([H])=C([H])C(F)=C2[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@@]([H])(O[H])[C@]1([H])F [H]N(C1=NC(=C([H])C([H])=N1)C1=C([H])N=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])OC([H])([H])[H] [H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C2C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]22C([H])([H])C3=C(C4=C(N3[H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]12O[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])([S@](=O)C([H])([H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(SC2=C1C([H])=C([H])C(=N2)C1=C([H])C([H])=C([H])S1)C(=O)N([H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@]4([H])C([H])([H])C([H])([H])[C@@]5(O[H])[C@]6([H])N(C([H])([H])C7([H])C([H])([H])C7([H])[H])C([H])([H])C([H])([H])[C@@]55C7=C(C([H])=C([H])C(O[H])=C7O[C@@]45[H])C6([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N1C(=O)C([H])=C(N=C1C([H])([H])C1=NC2=C(Br)C([H])=C([H])C([H])=C2O1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N1C([H])([H])C([H])([H])N2C([H])([H])[C@@]([H])(C([H])([H])N([H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]N([H])C1=C(SC2=C1C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(N=C([H])N=C2S1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C1=C([H])N=C2N=C(OC2=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] NC1=NC(=CC=N1)N1C=C(C2=COC=C2)C2=C1C=CN=C2 [H]N([H])S(=O)(=O)C1=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])C2=C(N=C3N2C([H])=C([H])C([H])=C3Cl)C([H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])[C@@]2(C1([H])[H])C([H])([H])C([H])([H])N(C(=O)N([H])[C@@]1([H])[C@@]3([H])C([H])([H])[C@]4([H])C([H])([H])[C@]([H])(C3([H])[H])C([H])([H])[C@@]1([H])C4([H])[H])C([H])([H])C2([H])[H] [H]ON([H])C(=O)C1=C(N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])N1C(=O)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2OS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)C(C(=O)OC([H])([H])[H])=C1C([H])([H])[H] [H]C1=C(C(=NN1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N([H])C1=NC(N([H])[H])=C(C#C[C@@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C(=N1)C([H])([H])C([H])([H])[H] [H]N(C1=NN=C(C2=C1C([H])=C1C([H])=C([H])C([H])=C([H])N21)C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])N2C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C([H])=C([H])[H])[C@@]2([H])C([H])([H])C([H])=C([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])([H])C([H])([H])C4=C([H])C([H])=C(OC([H])([H])[H])C([H])=C34)C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(SC([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(Cl)N=C2N([H])C([H])([H])C1=C([H])C([H])=C([H])C(I)=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(C#CC2=C([H])N=C([H])N=C2N([H])C2=C([H])C(Cl)=C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])=C2[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)=C1[H] [H]N(C1=C(C(=O)N(C(=O)N1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])[S@@](=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C2C([H])([H])[C@@]3([H])C(=O)C([H])([H])[C@]4(C([H])([H])[H])[C@@]([H])([C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]4(C([H])([H])[H])[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2(C([H])([H])[H])C([H])([H])OC(=N[C@@]2([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C1=C(C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])C#CC1=C([H])C2=C(C([H])=C([H])N=C2C([H])=C1[H])C1=C([H])N([H])C([H])=C1[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=C(C2=C([H])C([H])=C(O[H])C([H])=C2C([H])([H])[H])[C@]2([H])[S@@](=O)[C@@]1([H])C([H])([H])[C@]2([H])S(=O)(=O)OC1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C([H])N2C1=NC(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C3=NC(C#N)=C([H])C(=C3C([H])=C2C([H])([H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C3=O)C1=C([H])N(N=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C(C#CC([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1C(=C([H])S2)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C(=O)N2[H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N2C(=C1[H])C(OC(=O)C([H])([H])[H])=C(SC1=C([H])C(Cl)=C([H])C([H])=C21)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])(C3=NC(=NN3C3=C(Cl)C([H])=C([H])C(Cl)=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])[C@]([H])(C2=C([H])C([H])=C(F)C([H])=C2F)C1([H])[H] FC1=CC=C(NC2=CC3=C(C=C2)C(=O)C2=C(CC3)C=CC(OCCN3CCOCC3)=C2)C=C1NC(=O)C1=COC=C1 [H]ON([H])C(=O)C([H])([H])N1C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2N([H])S1(=O)=O [H]O[C@]([H])([C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])OC(=O)N(C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])=C(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C([H])([H])[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2O1 [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] C[C@H]1COC2=C1C(=O)C(=O)C1=C3C=CC=C(C)C3=CC=C21 [H]C1=C(SC(=N1)C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C(F)(F)F [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C(=N1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC([H])=NC2=C([H])C3=C(C([H])=C12)N(C(=O)O3)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])N(C(=C2C(=O)N([H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=NOC(=C1[H])C([H])([H])[H] [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])N1C([H])=C([H])\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C1C([H])=C(Cl)C([H])=C2[H] [H]C1=C([H])C(=C([H])S1)C1=C2N=C([H])C(=C([H])N2N=C1[H])C1=C([H])C(=O)N(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])C1=NC(=C(S1)C(=O)C([H])([H])[H])C([H])([H])[H] O=C(N1CCC[C@@H](C1)C1=NC(=NO1)C1=CC=CC=C1)C1=CC=CO1 [H]C1=C([H])N(C(=N1)[S@](=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])N2C(Br)=C(N=C12)C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)OC1=C([H])C([H])=C2C(=C1[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1N=C(C([H])=C2[H])C([H])([H])[H] [H]N([H])C(=O)C1=C(SC([H])=C1[H])N([H])C(=O)C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2N=C(N([H])C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])C1=NC2=C(O1)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)[C@@]2([H])ON=C(\C([H])=C(/[H])C3=C([H])C([H])=C([H])O3)C2([H])[H])C([H])=C1[H] [H]N([H])C(=O)OC1=C([H])C(Cl)=C(N2C(=O)N([H])C([H])([H])C3=C2C([H])=C([H])C(SC2=C([H])C([H])=C(F)C([H])=C2[H])=N3)C(Cl)=C1[H] [H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([C@]1([H])C([H])([H])C([H])([H])[C@@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] O.O.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl.C(N1CCCNCCNCCCNCC1)C1=CC=C(CN2CCCNCCNCCCNCC2)C=C1 [H]N=C(N1C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N([C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CN1N=C(C)C=C1C(=O)NC1=CC=CC(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)=C1 [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C#N)C([H])([H])C([H])([H])N1C(=O)N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)N([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C(C([H])=NC2=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C2([H])[H] [H]N(C(=O)N([H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]N(N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N([H])C([H])=C2[H])C(\[H])=C1/C([H])=C(C([H])=C([H])C1=O)[N+]([O-])=O [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(S1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C([H])C(=C([H])C([H])=C2S1)C1=C([H])C([H])=C([H])C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])=C1[H] [H]N([H])C1=NC(=NC(=N1)C([H])([H])[H])C1=C(N=C2C([H])=C([H])C(=C([H])N12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])N([H])C1=NN([H])C([H])=C1[H] [H]N1C2=C([H])C3=C(C([H])=C2[C@@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[H])C(=C([H])C(=O)O3)C(F)(F)F [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N1C([H])=NC2=C1C([H])([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=NC3=C(N=C(N=C3N=C2[H])N([H])[H])N([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C(O[H])=C([H])C(C([H])=O)=C2O1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N([H])C(=O)C2=C1SC(=C2[H])C1=C([H])C([H])=NC([H])=C1[H] [H]C1=C([H])C2=C(C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C(=O)C([H])([H])C#N)C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])O2 [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C2=C(C3=C1C([H])=C([H])C(O[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])=C3[H])C([H])([H])C([H])([H])SC2([H])[H] [H]OC1=C(\C(=N\C(=O)C([H])(Cl)Cl)C2=C([H])C([H])=C([H])C(Cl)=C2[H])C(=NN1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=NN=C(O2)N([H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(C(=O)C([H])([H])[H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC1=C(C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2[H])C2=C(C([H])=C([H])C(Cl)=C2[H])S(=O)(=O)N1C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC([H])([H])[C@@]2([H])C(=O)C([H])([H])[C@]3(C([H])([H])[H])[C@]([H])(C(=O)[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])OC([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=NN(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C(OC([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)N3C(=C(C2=O)C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]([H])(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N([H])C1=C(OC([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)N=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C(=O)S\C(=C(\[H])/C(/[H])=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O [H]N1C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1C(=NC([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C(O2)[C@@]([H])(N2N=C([H])N=C2[H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])=C([H])C([H])=C2C1([H])[H] [H]N([H])C(=O)C1=C2N=C(N([H])C2=C([H])C([H])=C1[H])C(N(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(C(Cl)=C(OC([H])([H])[H])C(Cl)=C1[H])C2([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(C([H])=C2C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])[C@]1([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C2N=C(C([H])=C([H])C2=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H]