[H]N(C1=NC([H])=NC2=C1SC([H])=C2[H])C1=C([H])C2=C(N([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C3=C([H])C(C#N)=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=NN1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N(N=C1[H])C([H])([H])[H])C([H])([H])C#N [H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@]1(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])=C(C([H])([H])OC(=O)C(\[H])=C(/[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])[C@@]2([H])OC([H])([H])O[C@@]2(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C(=C(Cl)C(Cl)=C1N([H])C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)S(=O)(=O)N([H])[H] [H]N([H])C1=NC2=C(N=C(N([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C(=N1)N([H])[H] [H]C1=NC(OC2([H])C([H])([H])C([H])([H])N(C3=NC4=C(C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C1=NN(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=N1 [H]N(C1=C(Cl)C(=O)C2=C([H])C([H])=C([H])N=C2C1=O)C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(OC(=O)C3=C2C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C3([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(=C(Br)C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])N([H])C1=NC(=C([H])C(=N1)C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(C([H])=C3[H])N(C([H])([H])[H])C([H])([H])[H])C2=O)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC1=O)C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NOC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(N([H])C(=O)C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])Cl)C([S-])=S [H]N1[C@]([H])(SC([H])([H])[C@@]1([H])C(=O)C1=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1(C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[C@]([H])(C([H])([H])C1([H])[H])C(F)(F)F)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C(=C(O[H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C([H])C(C([H])=C([H])[H])=C2O1)C([H])([H])[H] [H]N([H])[C@]1([H])C2=C([H])C(OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] CC(C)(O)C1=NC=C(C=C1)C1=CN=C2NC(=O)N(CC3CCOCC3)C2=N1 [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N1C(=NC2=C1C(=O)N(C1=N[C@]3([H])C([H])([H])C([H])([H])C([H])([H])[C@]3([H])N21)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Br)=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(N([H])C2=NC([H])=NC3=C2C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C3[H])C([H])=N1 [H]N([H])C(=O)C1(N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(=C(Cl)C([H])=C1[H])C(F)(F)F [H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C2=C(Cl)C([H])=C([H])C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])C1=C(N([H])C(=O)N([H])C2=C(C([H])=C(N([H])[H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C2=C1C([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1N=C([H])N([H])C2=O)C([H])([H])O[H] [H]N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N2C3=C(N([H])C(=O)C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N3O[C@@]4(C([H])([H])[C@@]3([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=NC([H])=NC2=C([H])C([H])=C(\N=N\N(C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])[H])C([H])=C12 [H]N(C(=O)C1=C([H])N2C(=NC3=C([H])C(Cl)=C([H])C([H])=C3C2=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])N1[H])C1=NN([H])C([H])=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1F [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N1C([H])=NC(=C1[H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C2=C(C1=O)C1=C(N([H])C3=C1C([H])=C([H])C(OC([H])([H])[H])=C3[H])C1=C2C2=C(N1[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N(C1=NN(C(=N1)N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])SC(=C1[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C#CC([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]C1=C([H])C(=O)N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C([H])=C([H])C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C#N)=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C(=N[H])C([H])([H])[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[H])[C@]2([H])C([H])([H])C3=C([H])N([H])C4=C3C(=C([H])C([H])=C4[H])[C@@]2([H])C1([H])[H])C1=NC([H])=C([H])S1 [H]OC1=C2N([H])C(=NC2=C(C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C2C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C([H])C2=NC(=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(N(C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C1=NC([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] CN1N=C(C)C(C(=O)N(CC2=CN=CC=C2)C2CC2)=C1OC1=CC=CC(Cl)=C1Cl [H]C1=C([H])C2=C([H])C([H])=C([H])[N+](=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N=C1[H] [H]C([H])=C([H])C([H])([H])[C@]1([H])O[C@@]2(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]C#CC1=C2C(=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])N1C(=NC2=C1C([H])=C([H])N=C2[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C2C(N([H])C(=O)\C2=C(\[H])C2=C([H])C([H])=C([H])N2[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)=C([H])C(=C1[H])C([H])([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C4=C3OC([H])([H])O4)C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)C2=CC(Cl)=C(Cl)C=C2)CCCCC1 [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C1=NC2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(S1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C(N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2C1=O)C(=O)OC([H])([H])[H] [H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])N=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(=N\OC([H])([H])C1=C(N=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H])\C([H])([H])C([H])([H])[H] [H]OC1=NSC(N([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)=C1C#N [H]O[C@@]1([H])C2=C([H])C3=C(C([H])=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@]2(C([H])([H])[H])[C@](O[H])(C([H])([H])C([H])([H])C2=C(C([H])=C(F)C([H])=C2[H])C(=O)N([H])[H])C1([H])[H] [H]N(C1=C(Cl)C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C1=C2C([H])=C(OC([H])([H])[H])C(C#CC3=C([H])C([H])=C([H])C(=N3)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C2=NC([H])=C1C#N COC1=C(F)C2=C(CN(C[C@]3(CC(=O)NC3=O)C#CC3=CC=CN=C3C)C2=O)C=C1 [H]C1=C([H])C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(C([H])=N1)[C@@]1([H])SC([H])([H])C(=O)N1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(F)C(Cl)=C1[H])C1=C2C([H])=C(N([H])C([H])([H])C3=C([H])N(N=N3)C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C(Br)C2=NC([H])=C1C#N [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=C(C=CC=C1)N1C2=NC3=C(N2C=C1C1=CC=CC=C1Cl)C(=O)NC(=O)N3C [H]N([H])C1=NC2=C(C(=N1)C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])N([H])C(=O)N2C1=C(Cl)C([H])=C([H])C([H])=C1Cl [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C2=C(C([H])=C1[H])C(=NO2)C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C(=NN1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C(SC2=C([H])C([H])=C(Cl)C([H])=C2[H])=NN(C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N2[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N2C3=C(C(OC([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])N([H])C(=O)C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C([H])=NC3=C(C4=C(S3)C([H])([H])N(C([H])([H])[H])C([H])([H])C4([H])[H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])S[C@](C1=C([H])C([H])=C(Cl)C([H])=C1[H])(C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O\N=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N1C(Cl)=NC2=NC([H])=NC2=C1N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([O-])=O [H]C1=NC(=C([H])C([H])=C1C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N([H])C1=NC(=C([H])C([H])=C1[H])C([H])([H])N1C(=C([H])C([H])=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])S1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])[C@]2(C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H] [H]N([H])C(=O)C(=O)[C@]([H])(N([H])C(=O)[C@]1([H])C([H])=C([H])[C@@]([H])(N2N1C(=O)[C@@](N([H])[H])(C2=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=NC([H])=NC2=C1N=C([H])N2C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C(F)=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])[H])C([H])([H])C(F)=C([H])[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H] CC(NC(=O)C1=C(N)C2=C(C)C(Cl)=C(C)N=C2S1)C1=CC=CN=C1 [H]N(C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=NC(=NC2=C1C1=C(S2)C([H])([H])C([H])([H])C1([H])[H])C(\[H])=C(/[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])=NC(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C(=O)OC([H])([H])[H])C(O[H])=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])=C([H])C3=C2C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(C#N)=C([H])C([H])=C1C1=C([H])C([H])=C2N([H])C(=O)C([H])([H])OC(C2=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(O[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=O)N1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])SC([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N=C(OC2=C([H])C([H])=C(C(N([H])C(=O)C([H])([H])O[C@]3([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C2[H])[N+]([O-])=O)C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1C(=O)\C(O2)=C(/[H])C1=C([H])N(C2=C1C(=C([H])C([H])=N2)C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(O[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C(=O)O[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C2=C([H])C([H])=C3N=C(N=C(O[H])C3=C2[H])N([H])[H])C([H])=C1[H])C(=O)O[H] [H]N(C1=NC(=NC2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN=C(O1)C(=O)N([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H] COC1=CC=CC=C1C1=C2C=CC(OC3=CC=C(F)C=C3F)=NN2C=CC1=O [H]C1=NC2=C(C([H])=C([H])C([H])=C2N1C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C([H])N=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])N=C3N([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]O\N=C(/[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])N([H])C([H])=N3)C([H])([H])C2([H])[H])C([H])=C1[H] [H]C(=O)C1=C([H])OC2=C([H])C([H])=C(C([H])=C2C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(N(N=C1C(F)(F)F)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)OC2=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=N1)C(F)(F)F CN(C)CCCC(O)(C1=CC=CC=C1)C1=CC(CCOC2=CC=C(C=C2)C2=CC=C(C=C2)C(O)=O)=CC=C1 [H]C1=C(OC2=C([H])C([H])=NC([H])=C12)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H] [H]N1C([H])([H])C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]([H])(OC1=C([H])C([H])=C(F)C(=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N(C(=O)C(=C(C#N)C#N)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C1[H] [H]O[C@@](C1=C([H])N([H])C([H])=N1)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C(=C(C#N)C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N([H])C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] NS(=O)(=O)C1=CC=C(CN2CC3=COC4=CC=CC=C4C3O[Zn]22(Cl)(Cl)OC3C(CN2CC2=CC=C(C=C2)S(N)(=O)=O)=COC2=C3C=CC=C2)C=C1 [H]ON([H])C(=O)[C@@]([H])(C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])N1N=NC2=C(C([H])=C([H])C([H])=C2[H])C1=O [H]N(C1=NN([H])C2=C1C(OC([H])([H])[H])=C([H])C([H])=C2[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)S\C(=C(\[H])C2=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C2[H])C1=O [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N1C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C#N)C(=N\C1=C([H])C([H])=C(C#N)C([H])=C1[H])\N1C([H])([H])C([H])([H])C(=C2C3=C(C([H])=C(Br)C([H])=N3)C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=C([H])C(N([H])C(=O)N([H])C(C2=C([H])C(=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(OC(=O)C([H])([H])[H])C([H])([H])OC1=C(OC([H])([H])[H])C2=C(C([H])=C1[H])C(OC([H])([H])[H])=C1C([H])=C([H])OC1=N2 [H]N([H])S(=O)(=O)C1=C([H])C(=C(Cl)C([H])=C1S(=O)(=O)C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(=N1)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N([H])C1=C(C(=O)C([H])([H])[H])C(=NN(C1=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H]