[H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C(F)C(F)=C([H])C([H])=C1F)C([H])([H])[C@@]([H])(F)C1([H])C([H])([H])C([H])([H])N(C(=O)OC2(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C2N(N=C([H])C2=C1[H])C([H])([H])[H])C1=C(C(=NC2=C([H])C([H])=NN12)N([H])[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]\C(=C(\[H])C([H])([H])OC1=C([H])C2=C(C([H])=C([H])C(=O)O2)C([H])=C1[H])C1=C([H])C(=O)[C@](O1)(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C(=N1)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C(N([H])C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(O2)C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C(C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]ON([H])C(=O)C1=C([H])SC(Br)=C1N(C([H])([H])C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C2=C(F)C([H])=C(C([H])=C2[C@@]2([H])OC([H])([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(OC([H])([H])[H])C(F)=C1[H] [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C2=C(S1)C(=O)C1=C([H])C([H])=C([H])C3=C1C2=C([H])C([H])=C3[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C(=C2N1C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])C([H])([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])C([H])=C1[H] [H]N(C1=NN2C([H])=C3C(=NC2=C1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(=C1[H])[C@@]1([H])SC(=NN1C(=O)C1=C(F)C([H])=C(Br)C([H])=C1F)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])[H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])C1=C2C(SC(=C2C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])[H])=NC([H])=N1 [H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])[C@]([H])(N(C1=C2[H])C([H])([H])C(F)(F)F)C([H])([H])SC([H])([H])[H])C(F)(F)F [H]C1=C2C([H])=C(Cl)C([H])=C([H])C2=NC(=N1)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])SC1=C([H])C(=C([H])N2C(=O)C3=C(SC4=C3C([H])([H])C([H])([H])C([H])([H])C4([H])[H])N=C12)C(=O)C1=C([H])C([H])=C([H])C([H])=C1O[H] [H]C1=C([H])C(=C([H])O1)[C@@]1([H])OC(=O)[C@]2([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@]([H])(C(=O)[C@@]([H])(OC(=O)C([H])([H])[H])C([H])([H])[C@@]3([H])C([H])([H])OC(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C3=C(C([H])=C([H])C([H])=C3[H])N(C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H] [H]N(C(=S)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1OC([H])([H])[H] [H]C1=C(N=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(N1C(SC([H])([H])C#N)=NN=C1C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])[H] [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])N([H])C(=C(C(=O)OC([H])([H])C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]1([H])C1=C([H])C(Cl)=C(OC([H])([H])[H])C(Cl)=C1[H])C([H])(OC([H])([H])[H])OC([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C1=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S(=O)(=O)N1C([H])([H])C2=C(N(C(=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2C(=C([H])C3=C1[C@]1([H])C([H])([H])C(=C([H])C([H])([H])[C@@]1([H])C(O3)(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C(=O)C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1([H])[H] CN1C(CC2=CC=CC=C2)=NN=C1SCC(=O)NC1=C(C)C=CC(=C1)[N+]([O-])=O [H]N1C([H])([H])C([H])([H])[C@@]2(OC([H])([H])C3=C2C([H])=C(F)C(F)=C3[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2Cl)C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])[C@@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])C([H])([H])N2C(=O)C([H])=C(C([H])([H])[C@@]12[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@@](=O)(O[H])O[P@](=O)(O[H])OP(=O)(O[H])O[H])[C@@]1([H])O[H])N1C([H])=C([H])C2=C(C([H])=C(F)C(F)=C2[H])C1=O [H]OC(=O)[C@@]1([H])C([H])([H])[C@]1([H])[C@](N([H])[H])(C(=O)O[H])C1=C([H])C([H])=C([H])C2=C1[C@@]([H])(C1=C(O2)C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C2=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C([H])=C2C2=C1C(=NC([H])=C2[H])C([H])([H])[H] CC1=CC(O)=CC(C)=C1C[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](C(=C)C(O)=O)C1=CC=CC=C1 [H]OC1=C([H])C([H])=C(O[H])C2=C1OC1=C([H])C(OC([H])([H])[H])=C([H])C(O[H])=C1C2=O [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C3=C([H])C(=C([H])C(=C3[H])C(F)(F)F)C(F)(F)F)[C@]1(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]2([H])C1=NN=NN1C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC4=C([H])C([H])=C5C(=C4[H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C6=C(C([H])=C([H])C([H])=C6[H])[C@@]54[H])=C([H])C([H])=C13)C([H])([H])C2([H])[H] [H]OP(=O)(O[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])[P@@](=O)(O[H])C([H])([H])[H] [H]ON(C(=O)N([H])C([H])([H])C(=O)N([H])[H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H] [H]C1=C2OC([H])([H])OC2=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C3OC([H])([H])OC3=C2C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C(=NN1[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC([H])=NC2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C2=NC3=C(N2[H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])[C@]1([H])[C@]2([H])[C@]([H])(OC(=O)[C@]2([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C([H])([H])[H])C1=C([H])C([H])=C2C([H])=C(Cl)C([H])=C([H])C2=N1 [H]N(C(=O)[C@@]([H])(N([H])C1=C([H])C(=NC(=N1)N1C([H])=NC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N(C1=C2N=C(C([H])=C2N=C(N1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@]2(C(=O)N(C3([H])C([H])([H])C3([H])[H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]N1C2=C([H])C(=C([H])C([H])=C2C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(N1C([H])=NC([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(O[H])=C([H])C([H])=C2O1 [H]C1=C([H])C(Cl)=C(N2C(=O)C([H])=C([H])C3=C2C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C3C2=C([H])C([H])=C(F)C([H])=C2Cl)C(Cl)=C1[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1F [H]C1=C([H])C(C#N)=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=C2N=C(N3N=C([H])C([H])=N3)N(C2=NC(=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C2=C(N([H])C(=N2)C2=NC([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(N([H])C([H])([H])C([H])([H])[H])=C(C([H])=C23)[N+]([O-])=O)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1C(=O)O[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(O[H])=C1C(=O)OC([H])([H])[H])C([H])([H])[H] [H]N(\N=C1/C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(OC([H])([H])[H])C(=O)C1=C(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C#N)=C2C([H])=C([H])N([H])C2=N1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=NC([H])([H])C1([H])[H])C([H])([H])N1N=C([H])C2=C1C([H])=C([H])C(=C2[H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C1=O [H]N([H])C1=NC(N([H])[H])=C2C(=N1)N([H])C(SC1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H])=C2C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])O[C@@]1([H])C([H])([H])[C@@]([H])(N2N=NC3=C2N=C(SC([H])([H])C([H])([H])C([H])([H])[H])N=C3N([H])[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C(F)=C(F)C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NN=C(O1)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C(C([H])([H])[H])C([H])([H])N([H])C1=NC([H])=NC2=C1C1=C(S2)C(=O)N(C([H])=N1)C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]N1C([H])([H])C([H])([H])N2C3=C(C([H])=C([H])C(SC4=C([H])C([H])=C([H])C([H])=C4C([H])([H])[H])=C3[H])C([H])([H])[C@]2([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C2OC([H])([H])C([H])([H])C2=C(Br)C2=C1C([H])([H])C([H])([H])C([H])([H])O2 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C([H])=C([H])C(=O)N(C1=NC([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Br)=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C1=C(C([H])=C(N=N1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C2=O [H]C1=C([H])C([H])=C(OC([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C3N(C(=O)C(=O)C3=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])Br)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NC([H])=C([H])N=C1[H] [H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(C([H])=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C(N(N=C1C(=O)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3[H])C3=NC(=C([H])S3)C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C1=NN2C(Cl)=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C2C([H])=C(Cl)C([H])=C([H])C2=NC(=N1)C(=O)N(C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C([H])([H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]O[C@@]12C([H])([H])[C@@]3([H])C([H])([H])[C@@]([H])(C1([H])[H])[C@@]([H])(N([H])C(=O)C1=NC(=C([H])N=C1N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N([H])N=C1[H])[C@]([H])(C3([H])[H])C2([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=NC2=C([H])C(=C([H])C([H])=C12)N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1N([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C(=S)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C(C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(Cl)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(N([H])C2=NC3=C(C([H])=N2)C([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C32)C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C1(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)C2=C(N=C1C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1O2 [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=NC2=C(S1)C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C(F)=C([H])C2=C1N(C([H])=C2C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)S1 [H]C1=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C3=NOC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(S1)C([H])=C(F)C([H])=C2[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])\C(\[H])=C(/[H])C2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])=C1O[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(C(OC2=NC([H])=C([H])C([H])=C2C2=NC([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])N([H])[C@@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C([H])C(=C1[H])[N+]([O-])=O [H]OC1=C2C(=O)C3=C(C(=O)C2=C([H])C([H])=C1[C@@]1([H])O[C@]([H])(C([H])([H])[H])[C@@]([H])(O[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@@]1([H])OC(=O)C([H])([H])[C@@]1([H])O[C@]3([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2C([H])=C1[H])S(=O)(=O)C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])[H])[C@@]1([H])N=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=C(C(=C(S2)C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]OC(=O)C1=C([H])C([H])=C(OC([H])([H])[C@]2([H])N([H])[C@]([H])(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C#N)C([H])([H])C2([H])[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2F)C([H])=C1[H] [H]N(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[N@@+](C([H])([H])[H])(C([H])([H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C3=C(OC(=S)C([H])=C3[H])C([H])=C2O1 [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C(Cl)=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C1=C(N([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[C@@]2([H])C([H])([H])[H])C(=O)C1=O [H]OC(=O)C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])\N=C(\S[H])N([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C(=C1[H])[N+]([O-])=O [H]OC1=C([H])C([H])=C(C([H])=C1O[H])[C@@]1([H])N(C([H])=C([H])[C@]([H])(C2=C(Br)C([H])=C([H])C([H])=C2[H])[C@]1([H])[N+]([O-])=O)C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(O[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=NC2=C(N=C1[H])N=C(N=C2N([H])[H])N([H])[H])C(=O)O[H] [H]N(C(=O)C1=C(C(F)=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N1C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1([H])[H])C(=O)N([H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C(=O)N1N=C(C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N(C(=O)C2=C1C([H])=C([H])C(I)=C2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]O[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C(=C([H])N2C([H])([H])C1([H])[H])C(=O)O[C@@]([H])(C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1=C([H])C([H])=C2N([H])C(=O)\C(=C(/C3=C([H])C(=C([H])N3[H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[H])C2=C1[H] [H]\C(=C(\[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])C1=C([H])C([H])=C([H])C(=N1)C([O-])=O [H]N1C(=O)C2=C3C(N=C4N([H])C([H])=C([H])C([H])=C34)=C3N([H])C4=C([H])C([H])=C([H])C([H])=C4C3=C2C1=O [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])N(C1=O)C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])[C@]([H])(C(=O)O[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]([H])([C@]1([H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C(N([H])C(C#N)=C2C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(C([H])=C1O[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C([H])=N3)C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]OC1=C2N([H])C(=NC2=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C2C3=C(C([H])=C(N=C3N(C3=C([H])C([H])=C(OC([H])([H])[H])C(F)=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])N1C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=C([H])C(=NC(=N1)N([H])[C@]([H])(C1=NC([H])=C(F)C([H])=N1)C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C([H])C2=C([H])C([H])=C([H])C(=C12)S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=C(O1)C1=C([H])C([H])=C([H])C([H])=C1N(C(=O)C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])N=C([H])O1 [H]N(C([H])([H])C([H])([H])C1=C(N([H])N=C1C1=C([H])C([H])=C([H])S1)C1=C([H])N=C([H])C([H])=N1)S(=O)(=O)N(C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=NOC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=NN=C(N2C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C(F)C([H])=C(Cl)C(F)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C([H])([H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)C(F)(F)F)C1([H])[H] [H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C1N=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C2=C(N=C1C1=C(Cl)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1O2 [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N=C([H])N2[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N([H])C2=C([H])N=C([H])N=C2[H])C([H])=NC(=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]OC1=C([H])C([H])=C(C(N([H])C2=NC([H])=C([H])C(=N2)N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C2=C(OC1=O)C([H])=C([H])C(=C2[H])C([H])([H])[H] [H]OC(=O)C(=O)N([H])C1=C(C([H])=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1O[H])C(=N[H])N([H])[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])[H])=C1[H])C1=NC(=C(N=C1C([H])([H])C([H])([H])[H])N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C(C([H])=C(O[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]SC([H])([H])C([H])([H])C(=O)N([H])C1=C(Cl)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]N1N=C(C2=C([H])SC(C#CC([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])=C2[H])C2=C1C1=C([H])C([H])=C(C([H])=C1C2([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC1=NC(=C(N1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1F CC1=C(C=CC=C1Cl)C(=O)N1CCC[C@@H](C1)C1=NOC(=N1)C1=CC=CC=C1 [H]C1=C([H])C2=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C([H])C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3N=C2O1 [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)C([H])([H])C([H])([H])C(=O)N([H])C1=NC([H])([H])C([H])([H])C([H])([H])N1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C1=NN=C(O1)SC([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]12C([H])([H])C([H])([H])[C@@]([H])(C(=C([H])[H])C([H])([H])[H])[C@]1([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@](O[H])(C([H])([H])C([H])=C([H])[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)N(C([H])([H])C1=C(C([H])=C([H])N=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C(N=C(Cl)C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([O-])=O)C([H])([H])C([H])([H])SC([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C1=C(C#N)C(=C([H])C(=N1)N([H])C1=NN([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(OC1=C([H])C([H])=C(Cl)C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]1([H])C([H])([H])[C@](C3([H])[H])(C2([H])[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(O1)C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1C2=C(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])(C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(Br)=C2[H])C2=C1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=O [H]N([H])C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)OC2=C(OC([H])([H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]4([H])C([H])([H])C5=C(N([H])C6=C5C([H])=C(F)C([H])=C6[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(SC2=NN3C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] FC(F)(F)C1=C(N=CC=C1)N1CCN(CC1)S(=O)(=O)C1=CC=C(NC(=O)C=C)C=C1 [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])\N=C(/S[H])N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(N=C12)C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])[H] [H]C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]([H])(C1=NN=NN1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]N(C(=O)C1=C(C2=C([H])C([H])=C(F)C([H])=C2[H])C2=C(N=C([H])C([H])=C2[H])C(=O)N1C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N([H])C(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])=C([H])\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C(F)N=NN1C([H])([H])[C@]1([H])OC(=O)N(C2=C([H])C([H])=C(C(F)=C2[H])C2=C([H])C([H])([H])S(=O)(=O)C([H])([H])C2([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C1=NC(=C([H])S1)C([H])([H])C1=NN=C(S[H])N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=CC2=C(CN(CC3(NC(=O)NC3=O)C#CC3=C4CCC5(NC(=O)NC5=O)C4=CC=C3)C2=O)C=C1 [H]N([H])C1=C(C([H])=NN1C1=C(F)C([H])=C(F)C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C12 [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])N=C([H])C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C3=NN(N=N3)C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N([H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])N2C(=C1[H])C(=O)N(C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(F)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C(C([H])=C2[H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=NOC(=C1Br)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)[C@]1([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C([H])=N1 [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N([H])C(=N2)C([H])([H])C2=C(Cl)C([H])=C([H])C([H])=C2F)C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C2C(=O)N(C(=O)C3=C2C1=C([H])C([H])=C3[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC(=O)C2=C([H])C(Cl)=C(N([H])[H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)[C@]1([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]O[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C([H])=C([H])C4=C([H])C(F)=C([H])C([H])=C34)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC(=C([H])S3)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C(=O)O[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H] [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1C([H])([H])N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])[C@@]([H])(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2[N+]([O-])=O)N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=C(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(O1)N([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2C1([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=NC([H])=C(N=C1[H])C(=O)N(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])[C@]2([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C([H])([H])N1N=NN=C1[C@]([H])(N([H])C(=O)C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H] [H]C1=NN(C2=NC(SC([H])([H])[H])=NC(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C12)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=NN(C(=O)[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C2=C([H])C3=C([H])C(Cl)=C([H])C([H])=C3N2[H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])[C@]([H])(C(=O)O[H])[C@@]1([H])[C@]([H])(N([H])[H])C(=O)O[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(N([H])[H])C([H])=C([H])C(OC3=C(C([H])=C([H])C([H])=C3[H])C(=N[H])N([H])[H])=C2[H])=C([H])C([H])=C1[H] [H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C#CC(=O)N([H])C1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N(C(=O)N1C(=O)N([H])C(=C(C(=O)OC([H])([H])[H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])N(OC([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NN2C(=O)C3=C(SC(=C3C([H])([H])[H])C([H])([H])[H])N=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C([H])([H])[H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(SC2=C(C3=C(N=C(N([H])[H])N([H])C3=O)N2[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C(C([H])=C2C(=N1)N([H])[H])C([H])([H])OC(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1OC([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC(=O)C([H])([H])[H])=C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])Br)C([H])=C1[H] [H]C1=C([H])C(C#N)=C([H])C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(C#N)=C2[H])C1([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C([H])([H])C2=C(C(=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N1C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2F)=C(C1=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])SC([H])([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]3([H])N(C(=O)[C@]([H])(N([H])[H])C([H])([H])C4([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C(=O)O[H])C([H])([H])C3=C([H])C([H])=C(O[H])C([H])=C3[H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(\N=C(/C([H])([H])C([H])([H])[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C(N=C1N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] CN(C)S(=O)(=O)C1=CC(=CC=C1C)N(O)=O [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C(=O)C([H])([H])C1=C(N([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C2([H])[H] [H]N([H])C(=S)N([H])\N=C(/C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C(Br)=C1[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=NC(=C3[H])N3C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C([H])=C21)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C([H])=C3C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=NN2C([H])=C([H])C(C(=O)N([H])C3=C([H])C([H])=C(N([H])C(=O)N([H])C4=C([H])C([H])=C(F)C([H])=C4[H])C([H])=C3[H])=C12 [H]N(C1=NC(=C(S1)C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl [H]N([H])C(=O)C1=C([H])N=C2C([H])=C(OC([H])([H])[H])C(N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C([H])C2=C1N([H])C1=C([H])C([H])=C(F)C([H])=C1F [H]OC1=NC(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C([H])S2)=NC([H])=C1C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])[C@@]2([H])N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C(=O)N(C(=O)C11C([H])([H])C([H])([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=N2)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2=C(C([H])=C([H])C(Br)=C2[H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C([H])([H])C(=O)O[C@@]1([H])O[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C(=O)OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C([H])C([H])=NN2C2=C1C([H])=C([H])N2C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C2=C(OC(F)(F)O2)C([H])=C1[H] [H]N(C1=C2C([H])=C([H])C([H])=C([H])C2=NC(=N1)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C1=NC2=C([H])C(=C([H])C([H])=C2N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C2C3=C(C4=C([H])C([H])=C(C(F)=C4N3[H])C3=C([H])C([H])=C(F)C(=C3[H])C([H])([H])[H])C([H])([H])C2=C1[H] [H]N=C1SC([H])([H])C([H])([H])N1C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])N1C(=O)C2=C([H])C([H])=C([H])C3=C2C(=C([H])C([H])=C3[H])C1=O [H]N(C(=O)C1=NC([H])=C([H])N=C1[H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]C1=NN(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C3C(=N2)C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NC(=NC(=N1)N([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)SC2=C1C([H])=C([H])C(=C2[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])C([H])([H])[H])C([H])([H])N([H])C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C(F)(F)F)=N1 [H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[N+]2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=NOC(=C1[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])N1C([H])([H])C(=O)N(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])[C@@]1([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O)C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC(=O)C([H])([H])[H] [H]S\C(=N/C([H])([H])C([H])([H])N(C1=NC([H])=C(C([H])=C1[H])[N+]([O-])=O)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=C(C([H])([H])[H])C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(C([H])([H])OC(=O)C([H])([H])[N+](C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]1([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C(=O)O[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=C(\C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])\C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])S1 [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C([H])=C([H])C2=C1C(=O)C(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C2C([H])([H])[H])S1)C1=C([H])C(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(Cl)=C([H])C(=C1[H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])N1C(=C(C(=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)C1=NC(=C([H])S1)C([H])([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O [H]C1=C([H])C(OC([H])([H])[H])=C2SC(=O)C([H])([H])N(C(=O)C2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N(C(=O)C([H])([H])C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C([H])=C2C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)OC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)OC([H])([H])[H] [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C2=C1C1=C3C(=C(Br)C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])[C@@]3([H])C2([H])[H] [H]OC(=O)C1=C([H])C([H])=C2N(C(=C(C2=C1[H])C([H])([H])[H])C([H])([H])N1C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])C1=NON=C1C1=NC2=C([H])N=C([H])C(OC3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])=C2N1C([H])([H])C([H])([H])[H] [H]O[C@@]1(C2=C(C([H])=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])N(C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]([H])(C(=O)N([H])C2=C([H])C([H])=C(C([H])=N2)N2C([H])=C([H])C([H])=C([H])C2=O)C1([H])[H] [H]C1=C([H])N(C(SC([H])([H])[H])=N1)C1=C([H])C([H])=C(C2=NN=C(N2C([H])([H])[H])C2(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]O[C@@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N([H])C3=C2N=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])C1=C2C(=NC(=C1C([H])([H])[H])C([H])([H])[H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(OC([H])([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])[N+]([O-])=O [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C(N=C1[C@@]1([H])N(C(=O)C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(C4=NC(=NO4)C4=NC([H])=C([H])C([H])=N4)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])=C(Cl)C(Cl)=C2[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])SSC1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])[C@@]1([H])SC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]O[C@@]([H])(C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])N([H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)N([C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]C1=NC(=C([H])N1C([H])(C([H])([H])[H])C([H])([H])[H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C2N(C([H])([H])C([H])([H])C2=C([H])C(=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])[C@]([H])(C#N)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])C([H])([H])F)=C(OC([H])([H])[H])C(=C1[H])C(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(N([H])[H])C([H])=C2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C(=O)C2=C1O[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])C([H])([H])N(C([H])([H])C(=N/OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])\C([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(SC([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NC([H])([H])C(=O)N(C2=C([H])C([H])=C(I)C([H])=C12)C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])N1[H])C1=C(C([H])=NC(=N1)N([H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(N=C1[H])C(OC([H])([H])OC([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C([H])=C(OC(=O)C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@@]2([H])OC([H])([H])C(=O)[C@@]12[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NSC3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C(C([H])([H])OC(=O)C([H])([H])[H])C([H])([H])S(=O)(=O)[C@@]2([H])N1C(=O)[C@]2([H])OC([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(OC([H])([H])C3([H])[H])C([H])=C2[H])C1=O [H]ON([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C2=C(OC1=O)C([H])=C([H])C(Br)=C2[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N2C(=O)N(C(=O)[C@@]2([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NN1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C([H])C(=C2[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C(=O)C([H])=C(C2=C([H])C(OC([H])([H])C3=C([H])C(=C([H])C([H])=C3[H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])[H] [H]N1C(=O)OC2=C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])[C@]4([H])C([H])([H])C5=C(N([H])C6=C5C([H])=C(F)C([H])=C6[H])C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C12 [H]N(C1=NC2=C(N=NN2C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C2C(SC([H])=C2C(=O)OC([H])([H])C([H])([H])[H])=C1[H])C1=NC([H])=NC2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C2[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C(=O)[C@@]2([H])C([H])([H])C([H])=C([H])C([H])([H])[C@@]2([H])C1=O)C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(C1=C([H])C(=C(O[H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])S[C@@]([H])(C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C#N)C(=O)N(C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(O[C@@]([H])(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]N(C1=NC(=C([H])C(=N1)C(F)(F)F)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1([H])C([H])([H])C(F)(F)C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(F)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C([H])([H])[C@]([H])(N3C(=NN=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C2=C1N(C(=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)O[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])SC2=C([H])C([H])=C([H])C([H])=C12 [H]C1=C([H])C(=C([H])C([H])=C1F)N(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(SC#N)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NC([H])([H])C([H])([H])N2C([H])([H])[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C2=C(S1)C([H])=C(Cl)C([H])=C2[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OC([H])([H])[C@@]2([H])O[C@]([H])(C3=NC(=C([H])S3)C(=O)N([H])[H])[C@]([H])(O[H])[C@]2([H])O[H])[C@]1([H])F)N1C([H])=NC2=C1N=C([H])N=C2N([H])[H] OC1=CC=C(\C=C\C(=O)NC2=CC(O)=CC=C2)C=C1 [H]N(C1=NC(=NC(=N1)C#N)N([H])C([H])([H])C([H])(F)F)C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N(C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])N1C([H])=NN=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])OC2=C([H])C([H])=C([H])C([H])=C2OC1([H])[H] [H]C1=NC(C#CC2=C([H])C(=C([H])C(C#N)=C2[H])[N+]([O-])=O)=C([H])C([H])=C1[H] [H]N1C(=NC2=C1N([H])C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C(=O)OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C1=C([H])C(=NC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])C([H])=C([H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(N1N=C(C2=C([H])C([H])=C([H])S2)C([H])([H])C([H])([H])C1=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] CCC1=C(CCCC(O)=O)C=NC=C1C1=NSC(=N1)C1=CC=C(OC(C)C)C(Cl)=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C([H])C1=O [H]OC(=O)[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])[C@@]2([H])N(C(=O)C([H])([H])C3=C([H])C4=C(N=C(O4)N([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])[C@@]([H])(F)C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C#CC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(O[H])C2=C3C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@@]3([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2(C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C2([H])[H] CCCN(CCC)C(=O)CN1C(=O)OC2=CC=C(C=C12)C1=CC=CC=C1 [H]N([H])C1=NC2=C(S1)C([H])=C(N([H])C1=C3C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])N([H])C([H])([H])C4([H])[H])=C([H])C3=NC([H])=C1C#N)C([H])=C2[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] O=C1NC2=CC=CC=C2N1C1CCN(CC1)C1CC2CCC(C1)N2CC1=CC=CC=C1 [H]N(C1=C(C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C(OC([H])([H])[H])(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])[N+]([O-])=O)[C@@]([H])(C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(\[H])=N\O[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2=NC3=C(S2)C([H])=C([H])C(F)=C3[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(N1C(=O)C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3N=C12)C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C(OC2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C(=C(Cl)C([H])=C3[H])C(F)(F)F)C([H])=C2[H])=C([H])C([H])=N1 [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NOC(=N1)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N(C1=C2N=C([H])N(C2=C([H])C(OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=NOC(=N2)C([H])([H])C2=C([H])C(F)=C(F)C(F)=C2[H])C([H])=C1[H] [H]C1=NC2=C([H])C(=C([H])C([H])=C2O1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])N(N=C1C1=C([H])C([H])=C(C#CC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C(=O)OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])(C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C2C(N([H])C(=O)C22C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC2=NC([H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])=C1[H] [H]N(C1=C2C(OC(=C2C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])=NC([H])=N1)C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]N1C2=NC([H])=C([H])C(C3=C(N=C(N3[H])C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C3=C([H])C([H])=C(F)C([H])=C3[H])=C2C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=[N+](C([H])=C(S1)C([H])([H])[H])C([H])([H])C1=C([H])C(OP([O-])(=O)OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C2[H])=C([H])C([H])=C1[H] CCCN(CCN1CCN(CC1)C1=CC=C(C=C1)C1=CC=CC=C1)C1CCC2=C(O)C=CC=C2C1 [H]O[C@@]([H])(C([H])([H])S[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C1=C(N([H])[H])N(N=N1)C([H])([H])C1=C([H])C(Cl)=C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(Cl)=C1[H] [H]N1C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2C(C#N)=C1C1=C([H])SC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N=C([H])O1 [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC(=O)[C@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2N(C([H])=C([H])C2=C1[H])C([H])([H])C1=C(OC(=N1)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]1(C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(S1)C([H])=C([H])C(F)=C2[H] [H]OC1(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[C@]2([H])OC(=O)N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(N([H])C(=O)C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])N1N=C([H])N=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl FC(F)(F)S(=O)(=O)NCC1CCN(CC1)S(=O)(=O)C1=CC2=CC=CC=C2N1S(=O)(=O)C1=NC=CC=C1 [H]OC1=C([H])C([H])=C(\C([H])=N\N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C2=C(N=C1[H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(Cl)=C([H])C([H])=C3[H] [H]N1N=C(C2=C([H])C([H])=C(N=C12)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C(C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=NC(=C(C([H])=C1[H])C1=NC(=C2N1C1=C([H])C(=C([H])C([H])=C1N=C2C([H])([H])[H])C(F)(F)F)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=NC2=C(N=C([H])N2[C@]2([H])O[C@]([H])(C3=NN(N=N3)C([H])([H])C([H])([H])[H])[C@@]([H])(O[H])[C@@]2([H])O[H])C(=N1)N([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@]2([H])C(=O)C3=C(C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C(Br)C([H])=C2SC(=NC2=N1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N1N=C(C(C([H])=C2C(=O)N([H])C(=S)N([H])C2=O)=C1[H])C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]N([H])C(=N/C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)\N=C(/N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)\N([H])C([H])([H])C([H])([H])C([H])([H])C1=C(N=C(S1)N([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C2C([H])=C3C([H])=C([H])C([H])=C([H])C3=C([H])C2=C1OC([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C([H])=C1[H] [H]N(C(=O)C(\[H])=C1\C2=C(C([H])=C([H])C([H])=C2[H])N(C(=O)C2=C(Cl)C([H])=C(C([H])=C2[H])N2N=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1(F)F)C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC1=C([H])C(Cl)=C(C([H])=C1[H])C1=C([H])C([H])=C2C([H])=C(O[H])C([H])=C([H])C2=C1[H] [H]N(C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])N([H])C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NC(N([H])C([H])([H])[H])=C(Cl)C([H])=N1)C1=C([H])C([H])=C([H])C([H])=C1OC([H])(F)F [H]N([H])C1=C(SC2=C([H])C([H])=C([H])C([H])=C2C([H])([H])N([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])=C(C(=NC1=O)N1C([H])([H])C([H])([H])C([H])(N([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C([H])[N+]([O-])=C1C1=C([H])C(Cl)=C([H])C([H])=C1[H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(C([H])=C(N=C2C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OC1=C(C([H])=C2C([H])=C3C([H])=C([H])C([H])=C([H])C3=C([H])C2=C1OC([H])([H])[H])C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C([H])=C1[H] [H]N([H])C([H])(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])S1)C1=NN([H])C2=C1C([H])([H])C1=C([H])C([H])=C(C([H])=C21)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])S(=O)(=O)N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]OC(=O)C1=C(N([H])C(=O)C([H])([H])OC2=C([H])C([H])=C3C([H])=C(O[H])C([H])=C([H])C3=C2[H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C3=C2C(=C1[H])S(=O)(=O)N3C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] OC1=C(O)C=C(\C=C\C(=O)NC2=CC=CC=C2F)C=C1 [H]OC1=C([H])C([H])=C2N([H])C([H])=C(C2=C1[H])C([H])([H])C([H])([H])N([H])C(=O)OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C1=NN([H])C2=C1C([H])=C(C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C(C([H])=C(OC([H])([H])C(F)(F)F)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=N1 [H]N([H])C1=NC(SC([H])([H])C2=NC([H])=C([H])N2[H])=C(C#N)C(=C1C#N)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]\C(=C1\SC(=S)N(C1=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C(Cl)C(Cl)=C1[H])C([H])([H])N1C2=NC(=C([H])C(=O)N2N=C1C([H])([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1N=C([H])C2=C1N=C(N1N=C(N=C21)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=O)N(C1=O)C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C(=O)C([H])=C([H])C1=O [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=NN2[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C(C2=NC3=C(C([H])=C([H])C(C#N)=C3[H])N2C([H])([H])[H])=C1C([H])([H])[H] [H]N1C2=C(C([H])=C([H])C([H])=N2)[C@@]2(C1=O)C([H])([H])C1=NC([H])=C(\C([H])=C(/[H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])Cl)[C@@]([H])(C3=C([H])C(F)=C([H])C(F)=C3[H])C([H])([H])[H])C([H])=C1C2([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]OC1=C(C2=C(N=O)C3=C([H])C([H])=C([H])C([H])=C3N2[H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]N(N([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]12C([H])([H])C([H])([H])[C@@]3(C(=C([H])C([H])([H])[C@]4([H])[C@@]5(C([H])([H])[H])C([H])([H])C6=C(N=C(N=C6[H])N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]5([H])C([H])([H])C([H])([H])[C@@]34C([H])([H])[H])[C@]1([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N(C([H])([H])C([H])([H])N1C(=O)N(C3=C([H])C([H])=C4SC(=NC4=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H])C2([H])[H] [H]O[C@@]([H])(C([H])([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C(F)C([H])=C(F)C([H])=C1F)C([H])([H])OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])N([H])[H] [H]N([H])C1=[N+]([O-])C(=C(Cl)C([H])=C1[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1N1N=NN=C1[H] [H]N(C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2F)C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)C([H])([H])C1=C([H])SC(=N1)N([H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N([H])[C@]([H])(C([H])([H])C1=C(F)C([H])=C([H])C(F)=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])SN=N2)C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])=C1[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])=C([H])C1=C2C([H])=NN1[H])C([H])([H])C(F)(F)F [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])S(=O)(=O)C3=C([H])C([H])=C(Br)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]N(C(=O)C1(N([H])C(=O)C2=C([H])C3=C(S2)C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C1=NC([H])=C(Br)C2=C1C([H])=C([H])C([H])=C2[H] [H]N([C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N([H])[C@]([H])(C([H])([H])C1=C([H])C(F)=C(F)C([H])=C1F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])N=C3N=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(OC(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=NN1S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=NN([H])C(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)N([H])C1=C(F)C([H])=C([H])C([H])=C1C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])OC2=C1[H] CC(C)(C)C1=CC=CC=C1NC(=O)C1=NC2=C(NS(C)(=O)=O)C=CC=C2C(O)=C1 [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2N=C1[H])[C@@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=NC2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C([H])C(Cl)=C1[H])[C@]2([H])N1C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N(C(=O)C([H])([H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])[H])C([H])([H])S[C@](C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(SC([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(N([H])C(=O)C2(N([H])C(=O)C3=C([H])C4=C(C([H])=C3[H])N(C(=N4)C3=C([H])OC([H])=C3[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C(ON=C1C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC1=NN=C(N1C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C2=NC([H])=C([H])C([H])=C2N1S(=O)(=O)C1=C([H])C([H])=C([H])C(Cl)=C1Cl [H]N1C(=O)C(=O)C2=C1C(=C([H])C([H])=C2Cl)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)=C1/C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]([H])(C1=NN2C([H])=C([H])C([H])=C2C(=O)N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C2C(OC3=C2C([H])=C(C([H])=C3[H])C2=NC([H])=C(S2)C([H])([H])[H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=NN(C2=NC(=O)C([H])([H])S2)[C@]([H])(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]1([H])OC([H])([H])C2=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])S3)C([H])=C2C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] CC1CCCN(C1)S(=O)(=O)C1=CC=C(C=C1)N1CCCC1=O [H]N1C(=O)S\C(=C(\[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1=O [H]ON(C(=O)N([H])C([H])([H])C([H])([H])SC1=NC2=C([H])C(Cl)=C([H])C([H])=C2S1)C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NC([H])([H])C([H])([H])C2=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C12)C([H])([H])[H] [H]OC([H])([H])C1=C(N([H])[H])C2=C(F)C([H])=C([H])C([H])=C2N=C1C([H])([H])[H] [H]N(C(=O)C1=C(N(C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C([H])=C([H])C1=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C(=NC2=C(C#N)C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1C(=O)\C(=C(/[H])C(=O)C2=C([H])N=C([H])C([H])=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C12 [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H][C@@]12CCN(CCCCCCNC(=O)CCCCCCC(=O)NCCCCCCN3CC[C@@]4([H])COC5=C(C=CC=C5)[C@@]34[H])[C@]1([H])C1=C(OC2)C=CC=C1 [H]N(C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]ON(\C(S[H])=N\C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C(=C1[H])[N+]([O-])=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])N=C(O2)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)N([H])C1=O [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[N+]([O-])=O [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])=C(N([H])C(=O)N([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C2=C(O\C(=C(\[H])C3=C([H])N(C4=NC([H])=C([H])C(N5C([H])([H])[C@@]6([H])O[C@]([H])(C([H])([H])C6([H])[H])C5([H])[H])=C34)C([H])([H])[H])C2=O)C([H])=C1[H])C1=C([H])N=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])[C@]([H])(O[C@]1([H])C([H])([H])OP(=O)(O[H])O[H])N1C([H])=C(C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])C1=O [H]C1=NC([H])=C(N1C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])SC(=S)[C@]1([H])C([H])([H])C([H])([H])[H] [H]C1=C(C2=C(N=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N(C2=O)C([H])([H])[H])N1C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])=C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C(N=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=N1 [H]C1=C([H])C(=C(Cl)C(C(=O)OC([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3S2(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C1Cl)S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N([H])C1=NC(N([H])[H])=C([H])C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])[C@]5([H])O[C@@]6(N([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C6([H])[H])[C@@]([H])(C([H])([H])[H])[C@]5([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C(=O)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])[C@]([H])(N([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1OC([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])[N+]([O-])=O)S(=O)(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=NC(=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2C([H])([H])N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]O[C@@]([H])(C([H])([H])OC1=C2C([H])=C([H])N([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C1=C(N2C([H])=C(N=C2N=C1C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])O1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])S1)C(=O)N([H])[C@]([H])(C1=NC(=NO1)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]O[C@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]1([H])N2C(=O)[C@@]([H])(N([H])C(=O)C3=NC([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)[C@]1([H])OC2=C(C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C(=O)N([H])[H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]SC1=NN=C(S1)N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(Cl)C([H])=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])C1=C(Br)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)(=NC(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1F [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N(C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(=O)[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(C3=NN=C(O3)SC([H])([H])C#CC([H])([H])OC(=O)C3=C([H])C(F)=C(F)C(F)=C3[H])=C2C([H])=C1[H] [H]C1=C(OC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])F)=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C(N=C(N1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(C(F)=C1[H])C([H])([H])[H])C2([H])[H] [H]N(C(=O)C1(C2=C(C([H])=C([H])C([H])=C2[H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[P@@]1(=O)OC([H])([H])[C@]([H])(N([H])C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])([H])O1)C([H])([H])C(F)(F)F [H][C@@]12C[C@H](OC(=O)C3=CC=C4OC(F)(F)OC4=C3)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]N(C(=O)C1=C([H])N=C([H])C([H])=N1)[C@@]([H])(C1=NN=C(N1C([H])([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])[C@]2([H])N([H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])[H])C([H])([H])C([H])=C([H])C2=C([H])C(OC(=O)N(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C12)[N+]([O-])=O [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] COC1=CC=C(C=C1O)C1=C2N(CCC3=C(O)C(OC)=C(OC)C=C23)C2=C1C1=CC(OC)=C(O)C=C1OC2=O [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N(C([H])([H])C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]N=C(N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])[C@]1([H])C(=O)OC([H])([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(Cl)=C2[H] [H]N(C(=O)C([H])([H])SC([H])([H])C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])[H])C2=C([H])C([H])=C(C(F)=C2[H])C(F)(F)F)C1([H])[H] [H]N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(=NN2C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2F)C([H])([H])[H])C([H])=C1[H] CC[C@@H](CO)NC1=C(C=NC(NC2=CC(Cl)=CC(Cl)=C2)=N1)C(=O)NC1CCN(C)CC1 [H][C@@]12CCO[C@]1([H])C1=CC(CCCCC)=CC=C1N[C@@H]2C1CCCCC1 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)C(=O)N1C([H])([H])[C@@]2([H])C([H])([H])N(C(=O)C([H])([H])N3C(=O)[C@@]([H])(N([H])S(=O)(=O)C4=C([H])C5=C([H])C([H])=C(Cl)C([H])=C5C([H])=C4[H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])[C@@]([H])(C1([H])[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#CC(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] CCN(CC)CCN1CCN(CC1)C(=O)COCCN(C)S(=O)(=O)C1=C(C)C=C(OC)C=C1C [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(N=C3N(C2=O)C([H])([H])C([H])([H])C2=C3N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=NC(=C3N2C([H])=C([H])N=C3N([H])[H])C2=C(F)C3=NC(=C([H])C([H])=C3C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C(C([H])=NC2=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(\C([H])=C(\[H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]([H])(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])[C@@]1([H])N(C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(O[H])=C2C(=O)C(O[H])=C(OC2=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(O[H])=C1[H] [H]OP(=O)(O[H])C([H])(N([H])C1=C([H])C([H])=C([H])C([H])=N1)P(=O)(O[H])O[H] [H]N1[C@]([H])(SC([H])([H])[C@@]1([H])C(=O)C1=C(N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] CC(C)C[C@H](CO)NC1=NC(SCC2=CC(=CC=C2)C#N)=NC2=C1SC(N)=N2 [H]N(C(=O)N([H])C1=C([H])C(C2=C(Br)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N(C(=O)C1=C([H])C2=C(N=C(O2)C2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(SC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C(C([H])=C(\C([H])=C2/OC(=O)N([H])C2=O)C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(N([H])C(=O)C2=C(C([H])=C([H])S2)S(=O)(=O)N([H])C2=C(Cl)C(=NO2)C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C(\[H])=C(\F)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=C1C(=O)N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@]([H])(C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C([H])([H])[C@]([H])(O[H])C2=C([H])C([H])=C(O[H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])Br)C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])O[H])C([H])([H])C2=C([H])C([H])=C(N([H])C3=NN([H])C(=N3)N([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(N([H])C3=NN([H])C(=N3)N([H])[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C1=NC2=C(O1)C(=C([H])C([H])=C2[H])C1=NC([H])=C([H])C([H])=C1[H] OC1=CC=CN(CC2=CC=CC=C2)C1=S CC1=CC(N[C@H](CCCCNCC2=CC=C(C=C2)C(C)(C)C)C(=O)NO)=CC(C)=C1F [H]ON([H])C(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)ON([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] COC1=CC=C(\C=C\C2=C(/C=C/C(=O)N3CCSCC3)C(OC)=CC(OC)=C2)C=C1 [H]N(C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1Br CN1C(=O)C(=CC2=CN=NC(C3=C(F)C=C(F)C=C3)=C12)C1=CC(=NC=C1C)C(=O)NC1CC1 [H]ON([H])C(=O)[C@]1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])N(C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C3C([H])=C(OC4=C(C#N)C([H])=C([H])C(=C4[H])C([H])([H])N4C([H])=NC([H])=C4C([H])([H])N([H])[C@]([H])(C1=O)C([H])([H])[H])C([H])=C([H])C3=C([H])C([H])=C2[H] [H]N1C(=S)N([H])\C(C1=O)=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12 FC(F)(F)OC1=CC=C(NC2=NC=NC(=C2)C2=CC=CC(=C2)C(=O)NCCN2CCOCC2)C=C1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(O[H])C([H])=C2OC1(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC(=NC(N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])=C1C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C(N([H])C(=N2)C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NN(C(=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N(C1=C([H])C(=C([H])C([H])=C1[H])C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C(OC(F)(F)C([H])(F)F)=C([H])C([H])=C1[H])C(F)(F)F [H]N1C(=O)C([H])([H])C2(C1=O)C1=C(C([H])=C([H])C(F)=C1[H])C1=C2C([H])=C(F)C([H])=C1[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])N([H])[H] [H]C1=C(OC2=C([H])C([H])=C(OC(=O)C([H])([H])[H])C([H])=C12)C(=O)C1=C([H])C2=C(O1)C([H])=C([H])C(OC(=O)C([H])([H])[H])=C2[H] [H]N(C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3O2)C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])[H])[C@@]([H])(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=N1)C1=C([H])C(=O)N(C(=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C4C(ON=C4C(F)(F)F)=C3C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]O[C@]([H])(C([H])([H])N([H])[C@]1(C2=C([H])C([H])=C([H])C(=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@@]1([H])C3=C(C(=C([H])C([H])=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C2=C([H])N=C(C3=C([H])C([H])=C(Cl)C([H])=C3[H])C(=N2)C2=C([H])C([H])=NC(Cl)=C2[H])C([H])([H])C1([H])[H] CC(C)(C)CC(=O)N[C@@H](CC1=CC=C(C=C1)C1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)C1=NC2=C(N1)C=CC=C2 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=NSN=C2SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])SC2=NSN=C2C2=C([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C1=NN=C(SC2=NC([H])=C(S2)[N+]([O-])=O)S1 [H]N([H])C(N1C([H])=C([H])C2=C1C([H])=C(F)C(F)=C2[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)[C@@]1([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]2([H])N(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C(F)(F)F [H]OC([H])([H])[C@]1([H])O[C@@]2(C3=C(SC([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(N([H])C(=O)C([H])=C2[H])C1=O)C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(N=C([H])C(=C2C([H])([H])[H])C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])=N1 [H]C1=C([H])C(OC([H])([H])[H])=C([H])C2=C1N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=C2C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C(=O)O[C@]2([H])C3=C(C([H])=C4OC([H])([H])OC4=C3[H])[C@]([H])(C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C3[H])[C@]3([H])C(=O)OC([H])([H])[C@@]23[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1=C(C(=O)N([H])[H])C2=C(S1)C1=C([H])N(N=C1C([H])([H])C2([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C(O[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] COC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1C(=O)NO)C(=O)C1=C(C)SN=N1 [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])C(=O)O[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C(=O)C([H])([H])Cl [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])O\C([H])=C(/[H])[C@]1([H])C([H])=C([H])C([H])=C([H])[C@@]1([H])C([H])=C([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=NC2=C([H])C(Cl)=C(Cl)C([H])=C2N2C1=NN=C2C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C(Cl)=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]O\N=C(\C1=C([H])N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C2N(C([H])=C1[H])[C@]([H])(SC2([H])[H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=NC(=NC(=C1[H])N1N=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(O1)C([H])([H])[H] CN(CC(=O)N1CCC[C@H]1B(O)O)C(=O)C1CCC(=O)N1 [H]OC(=O)C(F)(F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=NC(OC([H])([H])[H])=N1)N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(C(=O)O[C@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N1C2=C(N=C3N2C([H])=C([H])C2=C3C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C1=O [H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C([H])C([H])=C1[H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]\C(I)=C(/[H])C([H])([H])N1[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])[C@@]([H])(C(=O)C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])N1C([H])([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C(\[H])=C(/[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC([H])([H])C([H])([H])N1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C(C(=O)N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C(F)(F)F)C([H])([H])C2([H])[H])C2=C([H])C([H])=C(C([H])=C2S1)C([H])([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=NC(=NC2=C1C([H])([H])C([H])([H])N(C1=NC([H])=C([H])C([H])=C1C(F)(F)F)C([H])([H])C2([H])[H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=NN(C([H])=C2N=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=NN1C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])N(C1=C(Cl)C([H])=C([H])C(=C1[H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])[C@@]2([H])[C@@]([H])(C1([H])[H])[C@@]2(C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])OC([H])([H])C(F)(F)F [H]C1=C([H])C([H])=C(N2N=C3C(N=C([H])N(C3=O)C([H])([H])C([H])([H])C(F)(F)F)=C2C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(Cl)=C1[H] [H]N(C(=O)C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(N=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C(OC([H])([H])[H])C(=C23)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NOC(=N1)C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@@]12C(=O)C(=C([H])[C@@]1([H])[C@]1(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])=C(C([H])([H])OC(=O)C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C2([H])[H])[C@@]2([H])OC([H])([H])O[C@@]2(C(=C([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(F)C([H])=C(F)C([H])=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C(=O)C1=NN(C([H])=C1[N+]([O-])=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(=NN2C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(F)(F)F)[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([C@@]1([H])C([H])([H])C([H])([H])[C@](C2=C(F)C([H])=C([H])C(F)=C2[H])(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])SC1=NC([H])([H])C([H])([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(N([H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[N@@](C([H])([H])C2([H])[H])C([H])([H])C3([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1[H])[N+]([O-])=O)S(=O)(=O)N([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1C1=C([H])C(=C([H])C([H])=C1C(O2)(C([H])([H])[H])C([H])([H])[H])C(=O)OC([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C(Br)C(=N1)N([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C1=C([H])C([H])=C2N([H])C([H])=NC2=C1[H] [H]C1=C([H])\C(=N/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C(C([H])=C(C([H])=C2[H])C(F)(F)F)N1C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(F)=C(OC2([H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C([H])([H])C1=C([H])C([H])=C(N([H])C(=N[H])N([H])[H])C([H])=C1[H])P(=O)(OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])OC1=C([H])C([H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C(O[C@]([H])(C([H])([H])C2([H])[H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC1=C(C([H])=C2N(C(=O)OC2=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=O)N(C(=NC2=C1[H])C1=C([H])C([H])=C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(N=C(N2C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=C([H])C(Br)=C([H])N=C3N(C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N1 [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=N1)C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C(S1)C(=C([H])[H])C1=C([H])C2=C(C([H])=C1C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)[C@@]([H])(C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])[C@]2(C3=C(C([H])=C([H])C([H])=C3[H])[S@](=O)C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1=C([H])C(Cl)=C([H])C([H])=C1Cl [H]OC1=C([H])C([H])=C2C(OC(=O)C([H])=C2C([H])([H])SC2=NC([H])=C([H])C([H])=N2)=C1[H] [H]C1=C([H])C([H])=C2N=C(OC3=C([H])C([H])=C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C3[H])OC2=C1[H] CN1N=C(CC(=O)NC2=CC(Cl)=C(Cl)C(Cl)=C2)C2=CC=CC=C2C1=O [H]N([H])C1=NN=C([H])N1C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)[C@]1([H])C([H])([H])[C@]2([H])C([H])([H])N(C(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]2([H])C1([H])[H] [H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC(=C([H])S3)C3=C([H])C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C(O[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C(=NC(=O)C1=C([H])C([H])=C([H])C(Cl)=C1C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=[N+](C([H])=C1[H])C([H])([H])[H] [H]C1=C2C(ON=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3N(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])=C([H])C(F)=C1[H] [H]N=C(N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1(C(=O)OC([H])([H])C2=C1C([H])=C1N(C2=O)C([H])([H])C2=C([H])C3=C(N([H])C(\[H])=N\C([H])([H])[H])C([H])=C([H])C([H])=C3N=C12)C([H])([H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])OC2=C([H])C([H])=C([H])C3=C([H])C([H])=C(N=C23)C2=NN=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])[C@@]([H])(N(C(=O)C([H])([H])N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])O1)C(=O)C([H])([H])SC1=NN=C(N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])SN=N1)C([H])([H])C1=C([H])C([H])=C2C([H])=C(F)C(=C([H])C2=C1[H])C(F)(F)P(=O)(O[H])O[H] [H]N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C(=C13)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(\N=C1/C(=O)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C([H])([H])[H])[C@](C([H])([H])O[H])(C2([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C([H])=NC(=C1C([H])([H])N1C(=O)C(N([H])S(=O)(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C(C(=O)N([H])[C@@]([H])(C1=NN=NN1C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(=NC2=NC(=NN12)C1=C([H])C([H])=C([H])O1)N([H])C([H])([H])[C@]1([H])N(C([H])([H])C2=C([H])C(Cl)=NC([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] O=S(=O)(NCC1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1)C1=CC=CN=C1 [H]N([H])C1=C2C([H])=C(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=C([H])C2=NC(=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C1=C([H])C2=C(OC(=C2C(=O)OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])N([H])C(=O)[C@@]1([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C([H])=C1[H])N1N=C([H])C2=C(N([H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C3([H])C([H])([H])C3([H])[H])C([H])([H])[H])C([H])=C(C([H])=C12)C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(SC([H])([H])[C@@]1([H])OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]SC([H])([H])C(=O)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(C([H])=C([H])[C@@]([H])(C([H])([H])[H])[C@@]1([H])C(=O)O[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[C@@]2(C([H])=C([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])SC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=NC(=N1)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=N1)C1=C(N=C(SC([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(C(=O)N2C([H])([H])[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C(=C([H])C([H])=C1[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])C(=O)O[H])C(=O)C([H])([H])N([H])C(=O)C1=C([H])C2=C(S1)C([H])([H])C([H])([H])N([H])C2([H])[H] [H]C1=NN(C2=C1[C@]1(O[C@@]([H])(OC([H])([H])[H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(C([H])=C([H])C(OC2=C([H])C3=C(C([H])=C2[H])[C@@]([H])(C2=C([H])C([H])=C(SC([H])([H])[H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])C3([H])[H])=N1)C([H])([H])N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C(F)=C(N([H])C([H])([H])[H])C([H])=C2N2C([H])=NC([H])=C12)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])O\N=C(\C2=C(C([H])=C([H])S2)C([H])([H])[H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=NC(=NC([H])=C1[H])N1C([H])([H])C([H])([H])[C@]([H])(C2=C(F)C([H])=C(F)C(F)=C2[H])[C@@]([H])([N+]([H])([H])[H])C1([H])[H] CCNC(=O)C1=CC=C2N=C(C)C3=NN=C(N3C2=C1)C1=CN=CC(OC)=C1 [H]N(N1C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C(=O)C1=NN(C(C2=C([H])C([H])=C(S2)C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C(C#N)=C([H])C2=C3C(=C([H])C([H])=C12)C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C3([H])[H] [H]C#CC1=NC([H])=NC(N([H])[H])=C1C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=N1)N(C([H])=C(C(=O)OC([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F)C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C([H])=C2O[C@]1([H])C(F)(F)F [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]([H])(C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(OC(=O)C([H])([H])OC([H])([H])C(=O)OC3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C([H])=C4OC([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1OC([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C(=O)C(F)(F)C([H])([H])[H])C([H])([H])C1=C(F)C([H])=C(F)C(F)=C1[H] [H]N([C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C1=C([H])C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])S1)S(=O)(=O)C1=C([H])C([H])=C(S1)C1=NOC(=C1[H])C(F)(F)F [H]N(C1=C2C([H])=NN(C2=NC(SC([H])([H])[H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)NC1=CC=C2C=CC=CC2=C1 [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1SC1=NC([H])=NC2=C1C1=C(S2)C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C(N([H])C2=C([H])C(Cl)=NC(=N2)N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N1C(=O)[C@]([H])(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C(N([H])C3=C2C([H])=C([H])C([H])=C3[H])C1([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)C([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C(C2=C([H])C([H])=C([H])N2[H])=C2C(=O)N([H])C3=C([H])C([H])=C(F)C1=C23 [H]C1=C(C#N)C([H])=C([H])C(=N1)N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C(N=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]OC(C1=C([H])C([H])=C(F)C([H])=C1[H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H])[N+]([O-])=O)C([H])([H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C2=C1N([H])C1=C([H])C([H])=C(Cl)C([H])=C21 [H]OC([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(\C1=C([H])C([H])=C([H])C([H])=C1[H])=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])N2N=C1C([H])([H])C([H])([H])[H] [H]N=C(N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=NC2=C([H])C([H])=C3N=C([H])N(C(=O)C3=C2S1)C([H])([H])C([H])([H])[H] [H]C1=C([H])N(C(=O)N1C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]N=C(N([H])[N+]([O-])=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C1=O)C(=O)OC([H])([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(SC([H])=C2[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C2=NC([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])O1 [H]N(C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C(C([H])=C3[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(S1)C([H])([H])N1C([H])=C(C(=O)N=C1SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N=C1[H] [H]N([H])C1=NC(C2=C([H])C([H])=C([H])O2)=C2N=C([H])N(C2=N1)C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=NOC(=N1)C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=NN(C2=C([H])C([H])=C(C([H])=C12)N1C([H])=C([H])C(=C([H])C1=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1Cl)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(\C([H])=C(\[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])=C(F)C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]C1=C2C3=C(C([H])=C([H])C([H])=C3N1C([H])([H])[H])C(=O)N(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C21C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])[C@@](C2=C([H])C(O[H])=C([H])C([H])=C2[H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]C([H])=C([H])C(\[H])=C(/[H])C(=O)N([H])C([H])([H])C(=O)N(C1=C(Cl)C(=C(Cl)C([H])=C1[H])C([H])([H])OC1=C2N=C(SC2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N([H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C2[C@@]([H])(SC3([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(N([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C(OC([H])([H])[H])C([H])=C([H])C2=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1(C(=O)N([H])C2=C([H])C(Cl)=C([H])C(Cl)=C2C1=O)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=O)C([H])([H])[S@@]1=O [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C2=NC(=C([H])C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])(OC2=C(C([H])=C(F)C([H])=N2)N2C([H])([H])C([H])([H])C(F)(F)C([H])([H])C2([H])[H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C(C#CC2=NC(=C([H])C([H])=C2[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])\N=C(N([H])[H])/N([H])C(=O)[C@]([H])(N([H])[H])[C@]2(SSC([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]N(N([H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C3=C(S2)C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C1([H])[H] CCC1=C(C=CC=C1CCCC(O)=O)C1=NC(=CC=C1)C1=CC=C(OC(C)C)C(=C1)C#N [H]C1=NC2=C(O1)C([H])=C1C(=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])SC2=NN=C(N2C([H])([H])[H])C2=C3C([H])=C([H])C(=NC3=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] CC1=CC=C(C(C)=C1)S(=O)(=O)N1CCC(CC1)C(=O)NC1=CC=C(Br)C=C1 [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@]([H])(O[H])C([H])([H])C1(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@@](C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H] [H]OC(=O)C([H])([H])N(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])SC(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C([H])([H])OC([H])([H])C([H])([H])N1C2=NC3=C(N2C([H])([H])C([H])([H])C1([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])N1N=C(Cl)C([H])([H])C([H])([H])C1=O)C(=O)[C@@]([H])(C(=O)N2C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]SC([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C2=C(N([H])N=N2)C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])[C@]([H])(C([H])([H])[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] CC(C)(C)OC(=O)NCCN1CCN(CC(=O)NC23CC4CC(CC(C4)C2)C3)CC1 [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C(Cl)C(Cl)=C([H])C([H])=C1[H])C(=O)N([H])N1C([H])([H])C([H])([H])C2(C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)[C@]([H])(O[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]OC1=C(C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C(=N[H])N([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(F)=C1[H])C1=C([H])C(C2=C(Cl)C([H])=NN2C([H])([H])[H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=N3)C([H])=C2[H])C([H])=C1[H] [H]OC1=C(C2=C(O[H])C(N([H])C(=O)\C(=C(/[H])\C(\[H])=C([H])/[C@]([H])(OC([H])([H])[H])[C@@]([H])(OC(=O)N([H])[H])\C(=C([H])\[C@]([H])(C([H])([H])[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C2([H])[H])C([H])([H])[H])C([H])([H])[H])=C1[H])[N+]([H])([H])C([H])([H])[C@]([H])(O[H])C([H])([H])O[H] [H]N(C(=O)[C@]1([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])F [H]N(C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])C3=C([H])N([H])C([H])=N3)C2=NC([H])=C1C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C(F)=C([H])C(F)=C2[H])[C@@]2([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C1C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C1=NC([H])=C(N1[H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])C2=C(C3=C([H])C(F)=C([H])C(=C3N2C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC3=C(OC([H])([H])[H])C([H])=C([H])C(=C3[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C2C([H])=C3[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(N([H])C(=O)C2=C(O[H])C([H])([H])N(C2=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C(SC([H])([H])[H])S1)C1=C([H])SC(=N1)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C2=C(N([H])C3=C2C2=C(C(=O)N(N([H])C([H])(C([H])([H])O[H])C([H])([H])O[H])C2=O)C2=C3N(C3=C2C([H])=C([H])C([H])=C3O[H])[C@]2([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]([H])(O[H])[C@]2([H])O[H])C([H])=C1[H] [H]N1C(=O)\C(=C(/[H])C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C2=C(Cl)C([H])=C([H])C([H])=C12 [H]OC([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C3C([H])=C(F)C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]O[C@]([H])(C([H])([H])C(=O)N([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N1C(=O)N(C(=O)C2=C([H])C(Cl)=C([H])C([H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)N1C([H])([H])C([H])([H])C([H])(C(=O)C([H])([H])C([H])([H])[C@@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(Cl)C(C(=O)OC([H])([H])N2C(=O)C3=C(C([H])=C(OC([H])([H])[H])C([H])=C3S2(=O)=O)C([H])(C([H])([H])[H])C([H])([H])[H])=C(Cl)C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H] [H]N(C1=C([H])C2=C(N([H])C([H])=C2C2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]ON(C([H])=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])S(=O)(=O)C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] COC1=C2N=C(NC(=O)C2=CC(=C1)C1=CNN=C1)C(N)C1=CC=C(Cl)C=C1 [H]N([H])[C@]([H])(C1=NN=C(O1)SC([H])([H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C(=C2C(=N1)N([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C(=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=C3C([H])=C(C(=O)N(C3=N2)C([H])([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1P(=O)(O[H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])SC2=C([H])C([H])=C([H])C([H])=C2[H])C(=C1[H])[N+]([O-])=O [H]OC1=C(O[H])N=C2C(=N1)C([H])=C(Br)C(OC([H])([H])[H])=C2[N+]([O-])=O [H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N([C@]([H])(C(=O)C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN([H])C(=C1[H])C([H])([H])[H])C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)N(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] CC(C)N1CCC(CC1)OC1=CC=C2N3CCNC(=O)C3=CC2=C1 [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@](N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C2=NC([H])=C(O2)C2=C([H])N([H])C(=O)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])[C@@]([H])(C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C(Br)C(=NO1)C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C1N=NN2C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)[C@]1([H])OC3=C(C([H])=C([H])C(OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C3[H])[C@]1([H])C2=O [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN(C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]1([H])N(C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=C([H])C([H])=NC(SC([H])([H])C2=NC3=C(C([H])=C(C([H])=C3[H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=C3[H])C(=O)N([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)C([H])([H])C#C[H])C(O[H])=N2)=N1 [H]OC1=C(\N=N\C(=O)C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C2[H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]C1=C(N=C(S1)N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])C2=NC([H])=C([H])C(OC([H])([H])C([H])([H])[H])=C12 [H]O[C@@]1(C#C[H])C([H])([H])C([H])([H])[C@@]2([H])[C@@]3([H])C(=C4C(=C([H])C(=O)C([H])([H])C4([H])[H])C([H])([H])C3([H])[H])[C@]([H])(OC([H])([H])[C@]12C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(OC([H])([H])[C@]2([H])N([H])[C@]([H])(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C#N)C([H])([H])C2([H])[H])C(Cl)=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C(F)C([H])=C([H])C([H])=C1[H])[C@]2([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N([H])C(=O)OC([H])([H])[H])C2([H])[H] [H]C1=NN(C2=C1C([H])([H])[C@]1(C(=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C2=C(C3=C(N2C2=C([H])C(N([H])[C@@]([H])(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C1([H])[H])=C(C([H])=C2[H])C(=O)N([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C3=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1F)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C1C([H])=C([H])C(=C2[H])[N+]([O-])=O)C1=C([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1C([H])=C([H])C(F)=C2[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])=C2C([H])=C1[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C([H])([H])C1([H])SC([H])([H])C([H])([H])S1 [H]ON([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=N[H])C([H])([H])[H])C([H])=C1[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]1([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3OC([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])[C@]([H])(C1=C(N([H])C2=C1C([H])=C(S2)C(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C(OC2=NC([H])=C([H])C([H])=C2C2=C([H])C([H])=NC(=N2)N([H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NC([H])=C([H])S1)N([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1O[H] [H]N1C(=NC(=C1C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C(F)=C([H])C(F)=C1[H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C([H])C([H])=N2)C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]OC(=O)[C@]([H])(N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C1=O [H]OC(=O)C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)=C1[H] [H]N1C([H])([H])C([H])([H])C2=NC(=NC([H])=C2C([H])([H])C1([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]C1=C(N(C(=C1[H])C([H])([H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(C(=C1C([H])([H])[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])N=C(Cl)C([H])=C1[H] [H]N([H])C(=O)C1=C2N([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C3=C(C4=C(N3C(C([H])=C1[H])=C2[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C4=O)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(Cl)C(C(=O)OC([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C(=C([H])C(=C2O1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C1=NS(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=N1 [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C(C(=NC2=C1C([H])=C([H])N=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])C(=O)C(=O)C2([H])[H] [H]N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])N(C2=C1[H])C([H])([H])C1=NC(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1OC([H])([H])[H] [H]OC1=C2C(OC(C([H])([H])[H])(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@@]23[H])=C([H])C(=C1[H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC2(N([H])C3=C([H])C([H])=C([H])C(F)=C13)C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])C2([H])[H] [H]OC([H])([H])C(=C(/[H])C1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])SC([H])=C2[H])=C1[H])[N+]([O-])=O)\C1=C(Cl)C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C(C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])ON2C(=O)C([H])([H])C3(C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C2=O)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C(C([H])=C(C#N)C(=O)N1C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1Cl)C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]ON(C(=O)N([H])C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[C@]([H])(C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C(C(=O)OC([H])([H])[H])C(=C([H])S1)C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C([H])=C(Br)C([H])=C2C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C1C(=O)OC([H])([H])[H] [H]C1=C([H])C(=C(Cl)C(=C1[H])C(=O)\N=C1/SC(=C(N1C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)C1=C(N(C(=C1C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])[C@@]([H])(C([H])([H])SC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])C([H])(O[H])C([H])([H])C4([H])[H])C(=C3[H])S(=O)(=O)C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])=C([H])C2=C1C([H])([H])[C@]1([H])C([H])=C(C([H])([H])[H])C([H])([H])[C@]22N(C(=O)C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N(C(=O)C1=C([H])N=C(N2C([H])([H])C(=O)N(C([H])([H])C2([H])[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C2=NC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C([H])([H])[H])[C@]([H])(C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2=C([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]5([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[C@]45C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[N+]([O-])=O)N2C(=O)N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=NC2=C1OC(=N2)N1C([H])([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H] [H]N(C(=O)C1=C(OC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])N=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC2=C([H])C([H])=C(C([H])=C2S1)C1=C([H])C([H])=NC(OC([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=N1 [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1(C2=NOC(=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N([H])C2=C(C([H])=C(Cl)C([H])=C2[H])C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=N2)C([H])([H])C1([H])[H] [H]N(N1C2=C([H])C([H])=C(Cl)C([H])=C2N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(N=C12)C#CC1(O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC([H])=C([H])N2[H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C2=C([H])C(=C([H])C([H])=C2SC1([H])[H])[N+]([O-])=O)C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C2N([H])C(=O)C([H])=C([H])C2=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(OC(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(C(=O)O[H])[C@@]2([H])C3=C(C([H])=C([H])C([H])=C3[H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])[C@@]12[H] [H]O[C@]([H])(C([H])([H])[H])[C@]([H])(OC1=C(Br)C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)(=N[H])C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])[C@]1([H])C2=C([H])C([H])=C(F)C([H])=C2C([H])([H])C([H])([H])[C@@]1([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)O1)C([H])([H])C([H])([H])C#N [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)C([H])=C(OC([H])([H])[H])C(=C2[H])C(F)(F)F [H]OC(=O)[C@]([H])(OC1=C(I)C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])[C@]([H])(N([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]2([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C2OC3=C(OC(=O)C2=C1OC([H])([H])[H])C(Cl)=C(C(Br)=C3OC(=O)C1(C([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])P(=O)(O[H])O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C([H])S3)C([H])([H])C2([H])[H])C([H])=C1[H] [H]N([H])C1=C([H])C(=C(N([H])C(=O)N([H])C([H])([H])C2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])N(C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])N(C([H])([H])C(=O)O[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C#CC1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C2N(C(=C(C2=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=NN2C([H])=C([H])C(=C12)C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])ON1C(=O)C([H])([H])S[C@@]1([H])C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(Cl)C(Cl)=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]O[C@](C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])(C([H])([H])[C@@]1(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C(F)(F)F [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1N=C(C(=C1C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl)C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]1(O[H])C([H])([H])[C@@]([H])(O[H])[C@@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])[C@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])C1([H])[H] [H]N1C2=C([H])C([H])=C(C([H])=C2C2=C1C([H])([H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])([H])[C@]1([H])[C@@]2([H])C([H])([H])[H])C(F)(F)F [H]C1=C(OC([H])([H])[H])N=C(C(=C1[H])C1=C2N=C(N=C(N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])F)N2N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N1C(=O)N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C23)C(F)=C1[H] [H]N1C2=C(C([H])=C(Cl)C([H])=C2[H])C2=C1C([H])([H])[C@@]([H])(C2([H])[H])[C@@](F)(C(=O)OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=N1 [H]\C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(S1)N1C(=NN=C1C([H])([H])N=C2C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C(C(=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3N2S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=NC(=C(C(=O)N1C([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=O)C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]SC1=NN=C(N1N([H])[H])C1=C(C([H])=C(S1)N([H])C(=O)C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N=C1[H] OC1=C(Br)C=C(\C=N\NC(=O)C2=CC=C(C=C2)C2=NC=CC=C2)C(O)=C1Br [H]N1C(=O)C([H])=C(C2=C1C([H])=C1OC([H])([H])C([H])([H])N(C1=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]N([H])N([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C(F)=C([H])C([H])=C3N3C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]OC1=C(OC([H])=C([H])C1=S)C(=S)N([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)O[C@]([H])(C([H])([H])[H])C1([H])[H] [H]N(C(=O)[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])S1)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[N+]([H])([H])[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC([H])=C(N1C([H])([H])C1=NC([H])=C(C#N)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C(C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]OC([H])([H])C([H])([H])SC1=C(C#N)C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C(OC([H])(F)F)C([H])=C1[H] CC1CCC\C(C1)=N\NC1=NC(=CS1)C1=CC=CC=C1 [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C1(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C2C([H])=C([H])N(C(=O)C2=C([H])C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]S[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])N1N=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])C(=O)N([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C([H])=C2OC([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=NC([H])=C([H])S1)[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2N(C(=O)N([H])C([H])([H])C2=C1[H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CCN(CCOC)C(=O)C1=CC(=CC=C1C)N1N=C(C=C1NC(=O)NC1=C2C=CC=CC2=CC=C1)C(C)(C)C [H]OC(=O)C1=C2C(N=C(C(OC3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3C3=NN([H])N=N3)=C2C(=O)O[H])C2([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] CN1C=C(C=N1)C1=CC2=C(C=C1)N(C=C2C1CCN(C)CC1)C1=CC=C(F)C=C1 [H]OC1=C(F)C([H])=C2C(=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(N([H])C([H])([H])[H])C2([H])[H] [H]ON([H])C(=O)[C@]([H])(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])N(C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC1=NC2=C(N=C1O[H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(N(C(=C1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]C1=C2C(=NN1C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C(=NC1=C2C([H])=C([H])C([H])=C1[H])N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=C([H])C2=C1C([H])=C([H])C1=C2N(N=C1C#N)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])\N=C2/C(=O)N([H])C3=C([H])C([H])=C([H])C(=C23)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C2=NOC(=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C(\[H])=C(/[H])C(=O)OC([H])([H])C([H])([H])[H] [H]C1=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C2=C([H])C(C(=O)N3C([H])([H])[C@@]([H])(N(C([H])([H])[C@@]3([H])C([H])([H])[H])[C@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])[H])=C(Cl)C([H])=C2N1C([H])([H])[H] [H]N(C(=S)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1(C(=O)N([H])C2=NN=C([H])S2)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2C([H])=C3N(C2=C1[H])C1(C([H])([H])C([H])([H])C1([H])[H])C([H])([H])N([H])C3=O)C1=NC(=C([H])S1)C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])OC2=C([H])C([H])=C([H])C([H])=C2C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(O1)C1=C(N([H])C([H])([H])C2=C([H])C([H])=NC([H])=C2[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H] [H]OC1=C(O[H])C(C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])=C2C(=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C2C(=C1[H])N(C(=O)C([H])([H])C([H])([H])[N@@+]([H])(C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]ON(C(=O)N([H])[H])[C@]([H])(C1=C([H])C([H])=C(O1)C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(C1=C([H])C(N(C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] COC1=CC2=C(C=C1)C1=C(\C2=N\OCCN(C)C)C2=CC=CC=C2N=C1O [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C3=C(OC(=O)C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])SC2=NC3=C(O2)C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])C(=O)C1=C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])=C(OC([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C2=C(C3=C(C4=C([H])C([H])=C([H])C([H])=C4N3[H])C2([H])[H])C(O[H])=C1[H] [H]OC(=O)[C@@]1([H])N(C(=O)C(\[H])=C(/[H])\C(\[H])=C(/[H])C([H])([H])[H])C([H])([H])C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])C3=C(OC(=N3)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C2[H])C1([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(O[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@@]([H])(C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C2([H])[H])C([H])([H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=NC([H])=C4C([H])=C([H])C([H])=C([H])C4=N3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NON=C1[H])[C@@]1([H])C2=NN(C(=C2OC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)[C@@]([H])(N1C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])[H] [H]N(C(=O)C(OC1=C([H])C([H])=C(F)C([H])=C1Cl)(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])[C@@]2([H])C([H])([H])[C@@]3([H])C([H])([H])[C@]1([H])C([H])([H])[C@](C3([H])[H])(C2([H])[H])S(=O)(=O)C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C(\[H])=C(/[H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])=C1[H] [H]N1C(=C([H])C2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H]