[H]O[C@@]([H])(C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(N=C3N([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N([H])C(=NOC([H])([H])C1(C([H])([H])OC2=C([H])C(=C([H])C(=C2[H])C([H])([H])[H])C(=O)N(C([H])([H])C2=C([H])OC([H])=C2[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])N([H])[H] [H]O[C@]([H])([C@]([H])(C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[C@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C(SC3=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=N1 [H]N(C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@@]1([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=N[C@](C2=C([H])C([H])=C(F)N=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])[C@]1([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C(=O)N1[H] [H]N(C(=O)[C@@]1([H])N(C(=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC(=O)N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N3C(=O)C([H])([H])N(C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])S(=O)(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NOC(=N1)C([H])([H])OC1=C([H])C(Cl)=C(Cl)C([H])=C1Cl [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C2=NC([H])=NC([H])=C2[H])C2(C1=O)C([H])([H])C([H])([H])N(C([H])([H])C1=C(C([H])=C([H])C([H])=N1)C([H])([H])[H])C([H])([H])C2([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)[C@@]([H])(\C([H])=C(C([H])([H])[H])\C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])[C@@]2([H])C([H])([H])[C@@](O[H])(C(=O)C(=O)N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C(=O)O[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])[C@]3([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C(=O)N([H])C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])[C@@]([H])(OC([H])([H])[H])C3([H])[H])[C@]1([H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]2([H])OC([H])([H])[H])C([H])([H])C([H])=C([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C([H])([H])[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)N([H])C([H])([H])C(=O)C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])N(C1=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])=C2[H] [H]OC([H])([H])[C@]([H])(OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[P@](=O)(OC([H])([H])[C@]1([H])O[C@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]2([H])O[C@]([H])(O[C@@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])O[P@@](=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@]2([H])O[C@@]([H])(O[C@]12[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])[C@@]([H])(Cl)O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])[H])[C@]1([H])O[H] [H]OC(=O)C1=C([H])C(N([H])C(=O)C([H])([H])C2=C([H])C(O[H])=C(O[H])C(O[H])=C2[H])=C([H])C([H])=C1[H] [H]C1=NC(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C2=C1[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]N1C(=O)C2=C(C1=O)C1=C(C3=C2C2=C([H])C(=C([H])C([H])=C2N3[H])C(=O)C([H])([H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C2SC3=NC([H])=C([H])C([H])=C3C2=NC([H])=N1)C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C(C2=C([H])C3=C(C([H])=C2[H])C2(C(=O)N3[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C(F)=C1[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C2N=C([H])SC2=C1[H] [H]C1=C(C(N2C3=NC(=C(N3C([H])([H])C2([H])[H])C(=O)N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])C(Cl)(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])P(=O)(O[H])O[H] [H]N(C1=NC2=C(C([H])=N1)C([H])=C(N1N2C([H])([H])C([H])([H])C1=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N([H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C1=C([H])N([H])C([H])=N1 [H]N(C(=O)C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C(C([H])=N1)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C2=C([H])C([H])=C(F)C([H])=C2C2=C1C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(C([H])=C4[H])[N+]([O-])=O)C([H])([H])C3([H])[H])=C([H])C([H])=C12)C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])N=C(S2)C2=C(Cl)C([H])=C(O[H])C([H])=C2[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C2=C(C([H])=NC3=C(OC([H])([H])C([H])([H])O[H])C([H])=C([H])C([H])=C23)C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C1=C23 [H]N1C([H])([H])C2=C(Cl)C(Cl)=C([H])C(Cl)=C2C([H])([H])C1([H])[H] FC(F)(F)C1=CC(=CC=C1N1CCNCC1)N1C(=O)C=CC2=CN=C3C=CC(=CC3=C12)C1=CSC=C1 [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC2=C(SC(=C2[H])C([H])([H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=NC(=C(C(=N1)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N([H])\N=C1/C(=O)N([H])C2=C1C([H])=C([H])C([H])=N2 [H]N(C(=O)C1=C(C([H])=C([H])C(Cl)=C1F)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC(=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C#N [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@]3([H])C([H])([H])C(=O)N4C([H])([H])C([H])([H])C5=C(C([H])=C([H])C([H])=C5[H])[C@@]34[H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])S(=O)(=O)N2C([H])=C([H])C3=C2C([H])=C(Br)C([H])=C3[H])C([H])([H])C1([H])[H] [H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Cl)=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])OC(=O)C([H])([H])[H] [H]N(C(=O)C1=C(N(C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C1=NC([H])=C([H])O1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C(I)=C(OC2=C([H])C([H])=C(O[H])C(I)=C2[H])C(I)=C1[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=NC([H])=C2[H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C(=O)N([H])[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@]([H])(O[H])[C@@]1([H])O[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])S2)C(Cl)=C1[H] [H]O[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])N(C(=O)N([H])C2=C([H])C(Cl)=C(F)C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(OC2=NC(OC3=C([H])C(=C([H])C([H])=C3[H])C(=N[H])N([H])[H])=C(F)C(=C2F)C([H])([H])[H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C(N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C([H])([H])OC([H])([H])C1=C(C([H])=C(C#N)C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#N)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C([H])=C2N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(Cl)=NC2=C(C([H])=NN12)C([H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C2=C1C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C(=O)N([H])C([H])([H])C([H])([H])N1C(=O)C([H])([H])OC2=C1C([H])=C(N([H])C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])=C2[H] [H]N([H])C1=C([H])C([H])=C(C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])S1 [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)C(\F)=C(/C2=C(C#N)C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2C([H])=C([H])N=C3N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] C(N1CCCC(C1)OC1=CC=CC=C1)C1=CC=C(C=C1)C1=NN=C2N1C1=CC=CN=C1NC1=C2C=CC=C1 [H]N([H])C(=N/C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])N([H])C1=C([H])C([H])=C(N([H])[H])C([H])=C1[H])\N([H])[N+]([O-])=O [H]N([H])C(=O)C1(C2=C([H])C(F)=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])N3C([H])=C([H])N=C3C([H])([H])[H])=C2[H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])C([H])(C2=NOC3=C([H])C(F)=C([H])C([H])=C23)C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2C1([H])[H] [H]N([C@]1([H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]3([H])C([H])([H])C4=C(C([H])([H])[H])C([H])([H])[C@@]5(O[C@]6([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])N([H])[C@@]6([H])[C@@]5([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4([H])[C@]3([H])C([H])([H])C([H])([H])[C@]2([H])C1([H])[H])S(=O)(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C3=C(C([H])=C2[H])N(C(=O)S3)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C2=C(N=C([H])N2C([H])([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])N([H])C1=NC2=C(N([H])C([H])([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=C(SC2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])S1)C1=NC([H])=C([H])N=C1[H] [H]N([C@]([H])(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C(F)C([H])=N2)C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=NC(=C(C([H])=C1[H])[C@@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])S(=O)(=O)C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@]1(OO[C@@]2(C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C(OC([H])([H])C2([H])[H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=C(\[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])\C([H])([H])OC([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2OC(=C(C3=C([H])N(N=N3)C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])C3=C4C([H])=C([H])C([H])=C([H])C4=C(C([H])=C3[H])[N+]([O-])=O)C2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[S@@](=O)C1=NC2=C(C([H])=C([H])C([H])=C2N1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NN1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])C2=C(N(N=C2[H])C2=C([H])C([H])=C([H])C([H])=C2F)C([H])([H])C([H])([H])C1([H])[H] [H]N(\C(=N\C(=S)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)C1=C(N=C([H])N1C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])N([H])[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C(=N/C(=O)C([H])([H])[H])\N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1 [H]C1=C(N2C(=[N+]1C([H])([H])C(=O)O[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])=C(C2=C1C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3OC([H])([H])C([H])([H])OC3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C#N)C1=C(C([H])=C([H])N=C1N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])=C([H])C([H])([H])[C@]1([H])C1=NC(=NO1)C([H])([H])[H])C([H])([H])[H] [H]S[C@@]1([H])C([H])([H])N([C@]([H])(C2=NN=C(SC([H])([H])[H])N2C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C1([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=NC(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C([H])S2)=NC([H])=C1C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] FC1=CC=C(C=C1)C1=CSC(NN=C2CCCC2)=N1 [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(O2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C([H])=C([H])N=C2[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1(O[C@]([H])(C([H])([H])S1)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[N+]1(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])OP(=O)(OC([H])([H])[H])OC([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]N1C([H])=C(C2=C([H])C([H])=C([H])C(Cl)=C12)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(OC(=O)C(=C1C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])[C@@]([H])(C1=C([H])N=C(Cl)C(F)=C1[H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C#N)C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N(C3=C(C([H])=NC(=N3)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(O1)C([H])([H])OC(=O)C1=C([H])N=C(N=C1C(F)(F)F)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])[C@]34C([H])([H])[C@@]5([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C5([H])[H])C3([H])[H])C4([H])[H])C(C(=O)C([H])([H])[H])=C2OC1=O [H]OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])N(N1C([H])=NN=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N1C(=N[C@]([H])(C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])N1C(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C1=O [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])[H] [H]OC1=C(Br)C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=NN([H])N=N2)=C([H])C([H])=C1C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C(C2=C([H])C([H])=C([H])C([H])=C2F)=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N(C(=O)N(C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C2=C(C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [O-][N+](=O)c1ccc(Nc2ccc3C(=O)NNc3c2)nc1Nc1cc([nH]n1)C1CC1 [H]N(C(=O)C([H])([H])C1=C([H])N=C(O1)N([H])C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C(F)=C([H])C([H])=C1[H]