[H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N2C(=C1[H])N(C([H])=C(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=O)C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C(OC2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(C([H])=C3[H])C(F)(F)F)C([H])=C(C([H])=C2[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] FC1=CC=C(C=C1)C(=O)NCCN1CCC2(CC1)N(CNC2=O)C1=CC=C(Cl)C=C1 [H]OC1=C(C2=C(C([H])=C1[H])C1=C(OC2=O)C(=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] NC(=O)C1(CCOCC1)NCCCC1=NC(=NC(=C1)C1=CC(=CC=C1)C(F)(F)F)C#N [H]C1=C(F)C([H])=C2N3C(=NC(=C3C(=NC2=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(N=C(S1)C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])F)=C1OC([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(N1C(SC([H])([H])SC2=NN=C(N2N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2=C([H])SC(=N2)N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])=NN=C1C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C2=C(/[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N(C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])N=N1)C([H])([H])C#N [H]OC1=NC(=NC2=C1N=C([H])N2C([H])([H])C1=C(Cl)C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])[H] [H]N([H])C(=O)C1=C2N([H])C3=C(C([H])=C(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])=C3[H])C([H])([H])C([H])([H])N2N=C1C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)C([H])=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])=C4[C@@]5([H])C([H])([H])C([H])=C([H])[C@@]4(C([H])([H])C([H])([H])[C@]5([H])O[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H] [H]OC1=C(OC([H])([H])[H])C(=C([H])C(Cl)=C1[H])C(=O)N([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C(OC2=C1C(=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N([H])C(=O)C1=NN(C(=C1[H])C(=O)N1C2=C(C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C2ON=C(N([H])[H])C2=C1[H] [H]OC1=C(Cl)C([H])=C(N([H])C2=C(C(=O)N([H])C2=O)C2=C(C([H])=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])=C1Cl [H]N([H])C1=C2C([H])=C(SC2=C(C([H])=N1)C(=O)N([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(SC(=N1)N([H])[H])C([H])([H])C1=NN2C(S1)=NN=C2C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C2=C(N=C(N=C2C([H])([H])C1([H])[H])C1=C(ON=C1C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C(OC(=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])SC([H])([H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(O1)C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N(C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(Cl)C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC1=NN=C([H])N1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NN(C(N2C(=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1C1=C([H])C([H])=C2C([H])=C(C(=O)C([H])([H])[H])C(=O)OC2=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C(Br)C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1N=C(\C(=C(/[H])C2=C([H])N(C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C23)C([H])([H])[H])C1=O)C1=NC([H])=C([H])N=C1[H] [H]C1=NN(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])C(=O)N1C([H])([H])C2=NN=C(N2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(I)C([H])=C2[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C(=O)N([H])N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1C(=O)C1=C(N([H])N=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C1=NN(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C(=C([H])C([H])=C1[H])[C@]([H])(OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=NC([H])=N1)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)SC([H])([H])C1=O)C([H])([H])[C@@]1([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(C(=O)N([H])C([H])([H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])OC1=C2C([H])=C(Cl)C(F)=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]\C(=C1\SC(=NC1=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1OC([H])([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NC(=N1)C#N)C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C2N=C(C([H])=NC2=C([H])C([H])=C1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] CC1=CC2=NN=C(N2N=C1SC1=CC(=CC=C1)C(F)(F)F)C1=CC=CS1 [H]N1C(=O)C(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2F)=C2C(=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(N([H])C(=O)[C@]2([H])ON=C(C3=C([H])C([H])=C4OC([H])([H])OC4=C3Cl)C2([H])[H])C([H])=C1[H] [H]N(C1=NC(N([H])C([H])([H])[H])=C(F)C([H])=N1)C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C(=C([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C1[H] [H]N1C(=O)C2(N(C([H])([H])[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN([H])C2=NN=C(C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=C(C([H])=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])O[C@]1([H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])(C([H])([H])[H])C([H])([H])[H])[N+]([O-])=O [H]ON([H])[C@]([H])(N(C1=C([H])C(=NC([H])=N1)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=NC(=NS1)C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F)C([H])([H])[H])C([H])([H])O[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4([H])C([H])([H])C([H])([H])C4([H])[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]O[C@@]12C([H])([H])C3=C(N([H])C4=C3C([H])=C([H])C([H])=C4[H])[C@]3([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]13C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]2([H])C5([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C2=C(N=C1C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=NC([H])=N1)[C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C(Br)=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C#CC([H])([H])N1C(=O)C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC([H])([H])C1=C([H])C([H])=C(C(=C1[H])N(C1=NC(=NC([H])=C1[H])N([H])C1=C([H])C(=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C(N=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(F)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl FC1=C(F)C(F)=C(C(=O)C(=O)C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2Cl)C(F)=C1F [H]C1=C(Cl)C([H])=C2C(=O)C3=C(N(N=C3C([H])([H])[H])C([H])([H])[H])N(OC([H])([H])C([H])([H])C([H])([H])[H])C2=C1[H] [H]N(C(=O)C1=NN=C(O1)N([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])[C@]1(OC(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1F)C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]C1=C(C(OC([H])([H])[H])=NC(OC([H])([H])[H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NN=C(N1C([H])([H])[H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])[C@]([H])(C(=O)N1C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)O[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])N(C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])C(=O)N([H])C([H])([H])C1=NC2=C(N1[H])C([H])=C([H])C([H])=C2[H] [H]C([H])=C([H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H] [H]N1C2=C(N=C1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=S)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N2C(=O)[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]3(C([H])([H])C2([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C2(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C3=C(N=C([H])N=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C2N([H])C([H])=NC2=C([H])C(Cl)=C1[H])[C@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)N=C1[H])C([H])([H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C2F)C2=C([H])C(F)=C([H])C([H])=C2C1=O [H]C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C([H])C([H])=C(F)C([H])=C2C(C([O-])=O)=C1C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]C1=C(C(=O)N(C1=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])C(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])[C@@]2(C([H])([H])C2([H])[H])C([H])([H])N([H])[C@]1([H])C(=O)N1C([H])([H])C([H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=C(OC(=N1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C#CC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C([H])=N1 [H]N(C(=O)C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2N(C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]2([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C2([H])[H])S1(=O)=O)C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1F)S(=O)(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])SC(=N1)C1=C([H])N(C2=C(Cl)C([H])=C([H])C([H])=C12)C([H])([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C2=NN(C3=C(C([H])=C([H])C([H])=C23)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C(F)C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]OC1=C(C(=C([H])C([H])=C1C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(\C([H])=C2/SC(=S)N([H])C2=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C(C3=C([H])C([H])=C(C(F)=C3[H])C([H])([H])[H])=C2O[C@@]1([H])C(F)(F)F [H]C1=C([H])C([H])=C(O1)C([H])([H])N1C(SC([H])([H])C2=C([H])C([H])=C(Br)C([H])=C2[H])=NN=C1C1=C([H])C([H])=C([H])C([H])=N1 CN1CC[C@@H]([C@H](CCC[N+]23CCS[Re]22(=O)SCCN2C(=O)C3)C1)C1=CC=C(Cl)C=C1 [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC(=NC(=C1[H])N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C(C2=C([H])C(=NO2)C([H])(C([H])([H])[H])C([H])([H])[H])=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C(Cl)=C([H])C([H])=C12 CC1=CC(CNCCCC[C@@H](NC2=CC(C)=C(F)C(C)=C2)C(=O)NO)=CC=C1F [H]N1N=C2OC(=O)C([H])=C(C2=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)[C@@]2([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C(=O)C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1SC(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]S[C@@]([H])(C([H])([H])C(=O)N([H])C([H])([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])[C@]([H])(C#N)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C(O[H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])S1)C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C(C([H])=C(OC2=C(C([H])=C(C([H])=C2Cl)N2N=C([H])C(=O)N([H])C2=O)C([H])([H])[H])C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C#CC([H])([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1([H])C([H])([H])S[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2[H])[C@]1([H])O[H] [H]OC(=O)[C@@]1([H])N(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C(OC([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N1C(=C2C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]\C(=C(\[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C(=O)N(C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] C[C@H](CN1CCC2(CC1)N(CNC2=O)C1=CC=CC(F)=C1)NC(=O)C1=CC=C(Br)C=C1 [H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C(C([H])=C([H])C(F)=C3C([H])([H])[H])C([H])([H])[H])N(C3=C([H])N=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])[C@]2([H])C([H])([H])[C@@]1([H])[C@@]1([H])C(=O)N(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C(OC([H])([H])[H])C([H])=C([H])C([H])=C4[H])C([H])([H])C3([H])[H])C(=O)[C@@]21[H] [H]O[C@@]([H])(C([H])([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])[H])C([H])([H])[C@]([H])(C([H])([H])C1=C(OC([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC(N2C([H])([H])C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@@]23[H])=C2N=C(OC2=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(N=C(C(=O)N2[C@]([H])(C([H])([H])C([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])C(=C1[H])C1=C([H])C(C#N)=C(C([H])=C1Cl)C([H])([H])[H] CC#CCN1C(=O)C2=C(C=CN2CC2=CNC3=C2C=CC=C3)N=C1N1CCC[C@@H](N)C1 [H]N(C(=O)C([H])([H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C1=C([H])C([H])=C(SC2=NN3C([H])=C([H])C([H])=C3C(=N2)N([H])C2=NN([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])[C@]1([H])OC2=C([H])C([H])=C([H])C(SC([H])([H])[H])=C2C2=C1C1=C(N([H])C(C([H])=C1C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C2[H] [H]N(C(=O)C([H])([H])OC1=C([H])C2=C(OC(=C([H])C2=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])[H] [H]N(C1=NC(=NC(N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])=C1OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])N1C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])[N+]([O-])=O)C([H])([H])C1([H])[H] [H]C1=NC(=C2N1[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C21)C1=C([H])C([H])=C([H])N=C1[H] [H]N(C([H])([H])[H])C([H])([H])[C@]1([H])OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[C@]1([H])OC1=C([H])C([H])=C([H])C(F)=C1C([H])([H])[H] [H]N1C([H])([H])C(=C([H])C([H])([H])C1([H])[H])C1=C([H])N(C2=C([H])C([H])=C([H])C([H])=C12)S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(F)=C([H])C([H])=C1C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C(=O)N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C2=C(SC([H])=C2[H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=NN2C([H])=C(C([H])=C([H])C2=N1)C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H] [H]C1=C([H])C(N2C3=C(N(C(=N3)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N(C2=O)C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]C1=C([H])C([H])=C(O1)C1=NN=C2SC(=NN12)C([H])([H])C1=C([H])C([H])=C([H])S1 [H]OC(=O)C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])N2C1=NC(=C2C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1C([H])([H])C1=C(N(C(=S)N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N=C4C([H])=NC([H])=C([H])N34)C([H])([H])C2([H])[H])C1([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C(F)=C([H])C([H])=C3[H])=C([H])C([H])=C2O1 [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)C([H])([H])SC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C2SC3=C(C([H])=C([H])C([H])=C3[H])C(=NC2=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])C([H])([H])C1=NC(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])[C@@]3([H])[C@@]2([H])C([H])([H])N([H])C(=O)C2=C(N=C3SC([H])=C([H])N23)C([H])([H])[H])=C(S1)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])N=C(O1)C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C([H])=C1C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)N([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C2=C([H])N=C([H])C([H])=C2N1[H] [H]N1C2=NC([H])=C([H])N=C2C(=C1C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=NC(=C1[H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1OC([H])([H])C1=C(Cl)C([H])=C(F)C([H])=C1[H])C([O-])=O [H]N(C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C2C([H])=C([H])C(\C([H])=C(/[H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C([H])C2=NC([H])=C1C#N [H]O[C@@]1([H])[C@@]([H])(S[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C(N=C(Cl)N=C12)N([H])C1([H])C([H])([H])C1([H])[H] [H]N1C(=C([H])C2=NC(=NC(N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C([H])([H])[H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C(=C2[H])C([H])([H])[H])[C@]([H])(C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN([H])N=N1 [H]OC(=O)C([H])([H])C1(C([H])([H])S[C@@]([H])(C2=C([H])C(\C([H])=C(/[H])C3=NC4=C(SC(Cl)=C4Cl)C([H])=C3[H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])O[H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N=C(N(C1=O)C([H])([H])C1=C(SC([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C1([H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])N=C2[H])C([H])([H])C1([H])[H])(C([H])([H])[H])C(F)(F)F [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])(OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])(F)C([H])([H])C3([H])[H])C([H])=C2C([H])([H])N(C([H])([H])[H])C1([H])[H] [H]C1=C([H])C(OC([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])=C2OC([H])([H])C(C#N)=C([H])C2=C1[H] [H]N(C1=C(C([H])=NC2=C1C([H])=NN2C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(N([H])C2=C(N([H])[C@@]([H])(C3=NC([H])=C([H])O3)C([H])([H])C([H])([H])[H])C(=O)C2=O)C([H])=C([H])C([H])=C1C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C2=C([H])C(Cl)=C([H])C(C3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)N([H])[H])=C2O[C@@]1([H])C(F)(F)F [H]N1C2=C(C([H])=C([H])C([H])=C2[H])C2=C1[C@]([H])(N1C(=O)C([H])([H])N(C(=O)[C@]1([H])C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C1=C(Br)C(=NO1)C1=C([H])C([H])=C([H])C(=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)O[C@@]([H])(C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C#N [H]OC(C([H])([H])[H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=NC3=C(S2)N=C(N=C3N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C2=C(F)C([H])=C([H])C3=C2C([H])=C([H])N3[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC([H])=C1C([H])([H])N(C1=C([H])C(OC([H])([H])[H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])ON=C(C2=C([H])C([H])=C([H])C(Cl)=C2[H])C2=C([H])C([H])=C([H])C(Cl)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(C(\[H])=C(/[H])\C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C(\[H])=C(\[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C(=O)O[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C(N([H])[H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])([H])C([H])([H])C([H])=C1[H] [H]N(C(=O)C1(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C(=C(C([H])=C1[H])N1C(=O)C2=C(OC([H])([H])C(F)(F)F)C3=C(N=C([H])C([H])=C3[H])C(OC([H])([H])C(F)(F)F)=C2C1([H])[H])C([H])([H])[H] CCCCCC(=O)OC1=C2CN3CCC4=CC5=C(OCO5)C=C4C3CC2=CC=C1OC [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])[C@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])S2)C([H])([H])[C@]1([H])C([H])([H])[H] [H]N(C(=O)C(\[H])=C(/[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C2N=C([H])C(C#N)=C(N([H])C3=C([H])C(Cl)=C(SC4=NC([H])=C(S4)C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C2=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C2=NC3=C(N=C([H])N3C([H])(C([H])([H])[H])C([H])([H])[H])C(=N2)N([H])C([H])([H])C2=C([H])C([H])=C(S2)C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C(Cl)=N1)[C@]([H])(OC1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C1Cl)C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])[C@]1([H])SC([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[C@@]1([H])N(C2=NC([H])([H])[C@@]([H])(N2C1([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]N([H])C1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(I)S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]ON(C(=O)N([H])C([H])([H])C([H])=C([H])[H])[C@]([H])(C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H] CC1=CN=C(CNCC2(F)CCN(CC2)C(=O)C23CC4CC(CC(C4)C2)C3)C=C1 [H]C1=C([H])C([H])=C(S1)C([H])([H])N(C(=O)O[C@@]1([H])C([H])([H])[N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])S1 [H]OC1=C(Br)C([H])=C(\C([H])=N\N([H])C(=O)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C(O[H])=C1Br [H]N(C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C([H])C([H])=C([H])C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)=C2C(=N1)N([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C1=C([H])C2=C(C([H])=C1[H])C1=NC3=C([H])C([H])=C(F)C([H])=C3C(C([O-])=O)=C1C([H])([H])C2([H])[H])C(F)(F)F [H]C1=C(N2N=NC3=C2N=C(C([H])=C3N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C(SC([H])([H])[H])=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=C(Cl)N=C1C([H])([H])N([H])C(=S)N([H])C1=C([H])C([H])=C([H])C([H])=C1SC([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(OC2=C(C3=C([H])C([H])=C(O[H])C([H])=C3[H])C(=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C3=C([H])C([H])=C4N([H])C([H])=C([H])C4=C3[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C(OC2=C([H])C([H])=C(Br)C([H])=C2[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C(C2=O)=C34)C([H])([H])C1([H])[H] [H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(SC([H])([H])[H])=C([H])C(=C1[H])C(=O)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@@]([H])(C(\[H])=C(/[H])C2=C(\C(\[H])=C(/[H])C3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C(C([H])=C2C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]N([H])C1=NC([H])=C(C([H])=N1)C1=C([H])C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])=C([H])N=C1[H] [H]N([H])C1=NOC2=C([H])C([H])=C([H])C(=C12)C1=C([H])C([H])=C(N([H])C(=O)N([H])C2=C([H])C(Cl)=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C3=C(C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(S1)C([H])=C([H])C(=C2[H])C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N([C@]1([H])C([H])([H])C([H])([H])[C@@](C(=O)N2C([H])([H])C([H])([H])N(C3=NC([H])=C([H])C(=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])(C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])OC([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C1(C(=O)N([H])N([H])C(=O)C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N(C(=O)C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C(N=[N+]=[N-])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C(=O)N([H])[H] [H]O\N=C(/C1=C([H])C([H])=C(Cl)C(N([H])C(=O)C2=C(ON=C2C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F)C([H])([H])C(=O)N([H])C1([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C([H])C(C#CC3=C(F)C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C(=C2[H])N2C([H])=NC([H])=C2[H])C([H])([H])C1=O [H]N(C(=O)C([H])([H])C1=C([H])N(N=C1C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@]1(C([H])([H])C([H])([H])N2C([H])([H])[C@]3([H])C4=C(C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C4=C3C(=C([H])C([H])=C4[H])[C@@]2([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])S[H])C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C(C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1OC(=O)C2=C1N(C1=C(C([H])=C(F)C(Cl)=C1[H])C2=O)C([H])([H])C([H])([H])[H] [H]C([H])([H])N1C2=C(N(C(SC([H])([H])C(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=N2)C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C1=O)C([H])([H])[H] [H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(OC2=C([H])C([H])=C([H])C(=C2[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C2C([H])=C([H])C([H])=C(C2=NC([H])=C1C([H])([H])[H])C(F)(F)F [H]N(C(=O)N([H])C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])N2C([H])=C([H])N=C2C(=N1)N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C2N([H])C(=C(C(=O)OC([H])([H])C([H])([H])[H])C2=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H][C@]12CC[C@]([H])(C[C@H](C1)OC1=CC=CC(=C1)C(N)=O)N2[C@H](C)C1=CC=C(Cl)N=C1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C(Cl)=C(C([H])=C1[H])N1C(=O)[C@@]2([H])[C@@]3([H])C([H])=C([H])[C@]([H])(C3([H])[H])[C@@]2([H])C1=O [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C2=C([H])C([H])=C(O[H])C(C3=C([H])C(N([H])S(=O)(=O)C4=C([H])C([H])=C5N=C([H])C([H])=C([H])C5=C4[H])=C([H])C([H])=C3[H])=C2C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])SC([H])([H])C([H])([H])[C@@]1([H])C(=O)C([H])([H])[C@@]([H])(O[H])[C@]1([H])C(\[H])=C(/[H])[C@@]([H])(O[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C1=C([H])C(Cl)=C(N([H])C2=NC3=C(S2)N=C([H])N=C3N([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(Cl)=C1[H] [H]OC([H])([H])C([H])([H])ON([H])C(=O)C1=C(N([H])C2=C([H])C([H])=C(I)C([H])=C2F)C(F)=C(F)C(=C1[H])C([H])([H])N(OC([H])([H])[H])C(=O)C([H])([H])OC([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(O[H])N=C(N=C2C([H])=C1[H])C([H])(F)F)C(=O)O[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])C(=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C1([H])C([H])([H])C1([H])[H] [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])[H] COC1=CC=C(C=C1)C1=CC=NC(NC(P(O)(O)=O)P(O)(O)=O)=C1 [H]N1C2=C([H])C([H])=C([H])C([H])=C2C2=C1C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])[C@]2([H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(S2)C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]OC(=O)[C@]([H])(SC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N([H])N=C1[C@]1([H])C([H])([H])OC([H])([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C2(C3=C([H])C([H])=C(Cl)C([H])=C3Cl)C([H])([H])C2([H])[H])C([H])([H])C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C1([H])[H] [H]N(C1=C([H])C([H])=C(OC2=C([H])C(=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])[C@]3([H])SC(=O)N([H])C3=O)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])S(=O)(=O)C([H])([H])[H] [H]OC(=O)C([H])([H])N1C([H])=C(C([H])=NC1=O)C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@](N([H])C(=O)O[C@@]1([H])[C@@]2([H])C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C2([H])[H])C([H])([H])[C@@]1([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N([H])C(=O)C([H])(C1=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N=C(N([H])C1=C([H])C([H])=C2N(C(=O)C([H])([H])C([H])([H])C2=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])S1 [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(N([H])C2=C([H])C3=C(C([H])=C2[H])\C(=C(/[H])C2=C([H])C([H])=C([H])N2[H])C(=O)N3[H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=O)N1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC([H])=NC2=C1N=C(SC1=NC3=C(S1)C(Cl)=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])[H] [H]OC([H])([H])C1=C([H])C2=C(S1)C([H])([H])[C@]([H])(OC([H])([H])[H])O[C@]21C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=NC(=C(N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]N([H])C1=C(N=C(Cl)C(=N1)N1C([H])([H])C([H])([H])N([C@@]([H])(C([H])([H])C([H])([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C(=O)N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H] [H]C1=C(C2=C(C([H])=C([H])C([H])=C2[H])N1C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(O1)C#N)C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC2=C([H])C([H])=C(C([H])=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F NC(=O)C1=CC2=C(NC3=NNC=C3N=C2C2=CC=CC=C2F)C=C1 [H]N(C(=O)C([H])([H])OC1=C(Cl)C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N=C(C([H])=C(C2=C1[H])C([H])([H])[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(Cl)=C(C([H])=C1[H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[C@]2([H])N(C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@]2(OC(=O)C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON(C(=O)N([H])C([H])([H])C1=NC([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C1=NN2C(=N1)C([H])=NC([H])=C2C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C(N=C2C([H])=C([H])C(Cl)=NN12)C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]C(=O)C1=C(OC(=N1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N1N=NN=C1C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@]([H])(C1=O)C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C(O[H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])Cl)C([H])=C12)C1=C([H])C(Br)=C([H])C([H])=C1[H] [H]OC1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C(=C(C#N)C(=N1)N([H])[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)[C@@]2([H])OC(=O)C([H])([H])C2([H])[H])=C1[H] [H]N1N=C(N(C1=S)C([H])([H])[H])C1=C([H])C2=C(O1)C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]C([H])=C([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2=C(C([H])=C([H])C3=C2C(C([H])=O)=C([H])N3[H])C([H])([H])C1([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C(=O)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])=NN1C([H])([H])[H] [H]N(C1=C([H])C([H])=C2C(SC([H])=C2C(=O)OC([H])([H])C([H])([H])[H])=C1[H])C1=NC([H])=NC2=C1C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=NN=C2N=C([H])C(=NN12)C1=C([H])C([H])=C([H])S1 [H]N([H])[C@]([H])(C([H])([H])N([H])C1=C([H])C(\C([H])=C(/[H])C2=C([H])C([H])=NC([H])=C2[H])=C(Cl)N=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]C1=C([H])C([H])=C2C(SN=C2N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N3C(=O)C([H])([H])C(C([H])([H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])=C1[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=O)S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H] [H]N([C@]1([H])C([H])([H])N([H])[C@]([H])(C([H])([H])OC([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C2C(C([H])=NC([H])=C2C([H])([H])[H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C(=O)C1=C([H])C([H])=C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])C([H])=C1C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C2C(C([H])=NC([H])=C2S(=O)(=O)N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C3([H])[H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1([H])C(=O)C2=C(C([H])=C(N([H])C(=O)C3=C([H])N=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C(=O)N(C1=C([H])C(Cl)=C([H])C([H])=C1C(=O)O[H])C1=C2C([H])=C(O[H])C([H])=C([H])C2=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=NC2=NC(=C(N2C([H])=C1[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]([H])(N(C(=O)C([H])([H])C1=C([H])C(=C(F)C([H])=C1[H])C(F)(F)F)C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C(Cl)=C1[H])[C@@]1([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C2([H])[H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C([H])=C([H])S1)S(=O)(=O)N([H])C1=C(Cl)C(=NO1)C([H])([H])[H])C1=NC([H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C(N=C(N([H])C([H])([H])C2=NON=C2C([H])([H])[H])C1=O)C(C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])(OC(=O)C([H])([H])C([H])([H])C([O-])=O)C1=C([H])C([H])=C(OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(N1C([H])([H])C([H])(OC2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(=C(OC([H])([H])[H])C([H])=C1[H])C1=NC([H])([H])C(=O)N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N1C([H])([H])[C@@]2([H])C([H])([H])N(C3=C([H])C4=C(C([H])=C3[H])C3=C([H])C([H])=C(C([H])=C3C4=O)N3C([H])([H])[C@@]4([H])N([H])C([H])([H])[C@@]4([H])C3([H])[H])C([H])([H])[C@@]12[H] [H]C1=NC2=C(C([H])=C1[H])N1C(=NC(=C1C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H])N2C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[C@]1([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(N(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])=NC([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(SC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C(=O)N(C(=C(C1=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2C(=C([H])C([H])=C1[H])C([H])([H])[C@@]([H])(C([H])([H])N1N=C(C([H])=C([H])C1=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])OC1=NC2=C(N1C([H])([H])[H])C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])[H] CN1N=C(C)C=C1C(=O)NC1=C(Cl)C=CC(OC2=NN3C=C(NC(=O)C4CC4)N=C3C=C2)=C1 [H]N1C(=NC2=C1C(=O)N(C(=O)N2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])C(=S)N1N=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]O[C@@](C#CC1=C([H])C([H])=C(C#N)C([H])=C1C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])(C1=C([H])N=C([H])N1C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=NC2=C(SC([H])=C2[H])C(=O)N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C([H])C(OC(F)(F)F)=C1[H])C1=C([H])C(=NC(=N1)C#N)C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=NC(=N1)N1C([H])=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1C([H])([H])[H] [H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C2=C(C([H])=C([H])C([H])=C2S1)C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1N=C(N=C1C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])N1C(=O)[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1=O [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]N1C(=O)N(C2=C([H])SC(=N2)C2=C([H])C([H])=NC([H])=C2[H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C2N(C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C1=C2C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]1(ON=C(C2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])C1([H])[H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])(C2=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C(C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(=N1)N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])[H])C1([H])[H] [H]SC1=NN=C(N1N([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N=C(N([H])N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C(=C([H])N=C1[H])C1=C([H])N=C(S1)N([H])C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C(Cl)=C1[H])[C@@]2([H])N1C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=O)N(C(=O)\C(=C(\[H])/C(/[H])=C(\[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C(=O)N2C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C2C3=C(C([H])=C([H])C([H])=C3[H])C([H])([H])C2=C1[H])C([H])([H])[H] [H]N1N=C(C2=C1C1=C(SC(=C1C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]O[C@](C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C([H])=C1Cl)(C([H])([H])[H])C(F)(F)F [H]N(C(=O)C1=C([H])N=C(N=C1N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C#N)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] NC1=NNC2=NC(=CC(=C12)C(F)(F)F)C1=CC=CS1 [H]OC1=C([H])C2=C(N([H])C(=C2[H])C2=NN(C3=C2C(=NC([H])=N3)N([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])=C([H])C2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])OC3=C([H])C4=C([H])C([H])=C(C([H])=C4C([H])=C3[H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C12 [H]N(C(=O)[C@]1([H])N(C([H])([H])C([H])([H])[H])S(=O)(=O)C2=C([H])C3=C(OC([H])([H])C([H])([H])O3)C([H])=C2C1([H])[H])[C@]([H])(C(=O)C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C(N(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C#N)C1=C([H])C([H])=C(I)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(\[H])=C(/C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(=O)N(C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C1=C(C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(C([H])=C([H])C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])OC(=O)C([H])([H])[C@]1([H])N([H])C(=O)C1(C(=O)N([H])N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N1N=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN([H])C2=C1C([H])([H])N(C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C2=C1C(=O)C([H])=C(O2)SC1=NC(=C([H])C(=N1)C([H])([H])[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])C([H])=C([H])C1=C(C([H])=C(C([H])=N1)C1=C([H])N(N=C1[H])C([H])([H])[H])C2=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)[C@]([H])(C([H])([H])SC1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=NC([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C(C2=C(S1)C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])O\C([H])=C(\C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]1([H])C(=O)N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H] [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(N([H])C([H])([H])C([H])([H])C([H])([H])[H])=C([H])C([H])=C1Cl [H]N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@](C(=O)OC([H])([H])[H])(C1=C([H])C([H])=C(Br)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C(F)(F)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=N1 [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C([H])SC(=N1)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC2=C(S1)C([H])([H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C21)[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C([H])=C(Cl)C([H])=C23)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=C(C([H])=C(C([H])=N2)C2=C([H])C([H])=C(N=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])N(C([H])([H])C2=C(C([H])=C([H])C([H])=C2Cl)C(F)(F)F)C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])[C@@]([H])(N(C(=O)[C@@]([H])(O[H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])N(C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(Cl)=C([H])C(Cl)=C2[H])[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N([H])C1=C2C([H])=C([H])C(=C([H])C2=C([H])C([H])=N1)C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=C2C(=NC([H])=N1)N(N=C2C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] OC1=C(SC2=NC=NN2)C=C(NS(=O)(=O)C2=CC=CS2)C2=CC=CC=C12 [H]N1C([H])=C(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])N1C(=O)C2(C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C3=NC([H])=C([H])S3)C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C(=C1[H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])N(C(=O)C(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C(F)(F)F)C([H])(C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C(=O)N([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC2=C(C([H])=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])\C([H])=C([H])/C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C2=C(N1[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C#CC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C(C2=C(O1)C([H])=C([H])C(=C2[H])C1=C([H])C([H])=C(N=N1)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H] [H]N([H])C1=C([H])C(OC([H])([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1Cl)C(=O)N([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NC(N([H])[H])=C2C([H])=C(C([H])=C([H])C2=N1)N(C([H])([H])[H])C([H])([H])C1=C2C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])[C@]1(C(=O)N2[C@@]([H])(SC([H])([H])[C@@]2([H])C#N)C1([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])[C@@]1([H])C([H])([H])N(C2=NC([H])=NC(=C2[H])C2=C([H])SC([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C(F)=C(F)C([H])=C1F [H]N(C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C#N)C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])S1)C1=NN(N=N1)C1=C([H])C([H])=C([H])C(C#N)=C1[H] [H]ON([H])C(=O)[C@]1([H])N(C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])C1=C([H])N([H])C3=C1C([H])=C([H])C([H])=C3[H])C2([H])[H] [H]C1=NC(=NC([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(OC2=C([H])C(C#N)=C([H])C([H])=N2)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=NC2=C1C([H])=NN2C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1N([H])C(=O)N([H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C2=C3C(=NC4=C(C([H])=C(OC([H])([H])[H])C([H])=C24)C([H])([H])[H])N([H])N=C3C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])OC1=NC2=C(C(N([H])[H])=C(S2)C(=O)N([H])[H])C(=C1[H])C([H])([H])[H] [H]N([C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N(C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C(C#N)C(=C(S1)C1=NN=C(O1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])SC2=C([H])C(O[H])=C([H])C([H])=C2O[C@@]1([H])C1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])S([O-])(=O)=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])[C@@]1([H])SC2=C(C([H])=C([H])C(Cl)=C2[H])[C@@]1([H])OC([H])([H])C1=C(Cl)N=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])N(C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1([H])C([H])([H])N([H])C1([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N([H])C(=O)[C@@]2([H])N3C(=O)C([H])([H])N(C(=O)C([H])([H])C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])[C@]3([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])=C(N=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])[H])C([H])([H])[H] COC(=O)[C@@H]1C[C@@H](Br)C2=C3[C@@]1(C)CCC(C(O)=O)[C@]3(C)C[C@@H](O2)C1=COC=C1 [H]N([C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])S(=O)(=O)C(F)(F)F [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[C@@]1([H])[C@]2([H])O[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C1=NC(=C([H])O1)C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] OB(O)\C=C\C1=CC=C(C=C1)C1=CC=C(C=C1)C(F)(F)F [H]C1=NC2=C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])S(=O)(=O)C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])C1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])C22C([H])([H])C3(OC12C([H])([H])C3([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(C([H])=N2)C2=C([H])C([H])=C([H])C([H])=C2S(=O)(=O)N([H])[H])(C([H])([H])N([H])C([H])=O)C1([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=NC3=C([H])C([H])=C(C([H])=C3C([H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C(Cl)=C([H])C([H])=C2C(OC2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C(=C(\[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])\C(=O)OC([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[N@+]2(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N(C1=C(C(=NO1)C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H] [H]ON([H])C(=O)[C@]1([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(=C1[H])C(=O)OC([H])([H])[H])N1C(=O)O[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2N2C([H])=NC([H])=C12)C1=C(F)C([H])=C([H])C([H])=C1F [H]N1N=NC(=N1)C1=C([H])N=C([H])C(\C([H])=C(/[H])C2=C(C([H])=C(C([H])=C2C([H])([H])[H])C2=C([H])N=C([H])C([H])=C2[H])C([H])([H])[H])=C1[H] [H]O[C@@]([H])(C([H])([H])N(C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1[H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(Br)=C1Br [H]C1=C([H])C([H])=C(C2=NOC(=C2C(=O)N2C3=C(C([H])=C(Cl)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])[H])C(Cl)=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N2C([H])=C(C3=C([H])C([H])=C([H])N=C23)S(=O)(=O)C2=C(Cl)N=C3SC([H])=C([H])N23)C1([H])[H] [H]OC(C1=C([H])C(Cl)=C(C([H])=C1[H])N(C([H])([H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H])(C(F)(F)F)C(F)(F)F [H]N(C1=NC([H])([H])C2=C1C([H])([H])N(C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C1=NC(Cl)=NC2=C1SC([H])=C2[H] [H]OC(=O)C([H])(N([H])C(=O)C1(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])OC(=O)C1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C2=C(N([H])C(=C(C(=O)N([H])[H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C1=C2N=C(C([H])=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N2N=C1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C([H])C2=C(SC3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C([H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H][C@@]1(CCCCN1CC1=CN=CC=C1)[C@H](C(=O)OC)C1=CC=CC=C1 [H]C1=C(N=NN1C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C([H])C2=C([H])C3=[N+](C([H])=C12)C([H])([H])C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C31)N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C1=O [H]C1=NSC(=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C(N(C(=C1[H])C([H])([H])C(=O)N(C1=C([H])C([H])=C(Cl)C(=C1Cl)C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] CC(=O)N[C@@H](CC1=CC(F)=CC(F)=C1)[C@H](O)CNC1(CC1)C1=CC=CC(=C1)C1CCOC1 [H]O[C@@]12C([H])([H])C([H])([H])[C@@](C3=NC4=C(N3[H])C3=N[C@]([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N3C(=O)N4C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]C([H])=C([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])N2C([H])=NC(=C2[H])C([H])([H])C#N)C([H])([H])C1([H])[H] C[C@H](N)C(=O)N1CCC[C@H]1B(O)O [H]N(C(=O)N1C([H])([H])C2=C(N=C(N=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(Cl)N=C2[H])C([H])([H])C1([H])[H])C1=C([H])N(N=C1[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])N(C(=O)C2=C([H])C([H])=C(O2)C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C(=N2)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C4=C([H])C5=C(C([H])=C4[H])N(C(=O)C5([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C3([H])[H])=C2C([H])=C1[H] [H]O[C@]1([H])[C@]([H])(O[H])[C@]2(C(=O)N([H])C([H])([H])[H])C([H])([H])[C@]2([H])[C@@]1([H])N1C([H])=NC2=C1N=C(N=C2N([H])C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1[H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N(N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1=C(C(=O)OC([H])([H])[H])C(=C(S1)C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]ON([H])C(=O)C(\[H])=C(/[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2([H])[H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C#CC2=C([H])C([H])=C(F)C([H])=C2F)C1=O [H]N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])[C@@]([H])(C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])SSC([H])([H])C1([H])[H])C([H])([H])C2([H])[H] NC(=O)[C@@H]1CCCN1C(=O)C1=CC=C(NC(=O)C2=CC=C(C=C2)C(F)(F)F)C=C1 [H]OC(=O)C1=C([H])C([H])=C(N([H])\N=C2/C(=O)N([H])C3=C2C([H])=C(C([H])=C3[H])S(=O)(=O)N([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=NC2=C1N=C([H])N2[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])O2 [H]O[C@@]1([H])C([H])([H])N2C(=O)N(C(=O)[C@]2([H])C1([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(C([H])=C1[H])[N+]([O-])=O [H]N([H])C([H])([H])C1=C(N=C(O1)C1=C2C([H])=C([H])C(=NC2=C(OC([H])([H])[H])C([H])=C1[H])C(F)(F)F)C(=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])[C@]2(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])O2)C([H])([H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]\C(I)=C(\[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3C([H])([H])[C@@]12[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])C([H])([H])[C@@]2(OC(=O)C3=C2C([H])=C([H])C2=C3OC([H])([H])C([H])([H])O2)C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C(N=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(C2=NN=C(N2C([H])([H])[H])C2=C([H])C([H])=C([H])C(=C2C(F)(F)F)C(F)(F)F)=C(C([H])=C1[H])C(F)(F)F [H]OC(=O)C1=C(C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N=C(N=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1([H])C([H])([H])C1([H])[H] [H]ON(C(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N=C(N([H])C(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C([H])=C1[H] [H]C1=NC(=C([H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(SC2=C(C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=C1[H])C(F)(F)F [H]O[C@@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H])[C@]([H])(N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])C#C[H])C([H])([H])C1=C([H])C2=C(N=C(N=C2O[H])C([H])([H])[H])C([H])=C1[H])C(=O)O[H])C(=O)O[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C2([H])N(C([H])(C3=C(Cl)C([H])=C([H])C([H])=C3[H])C3=C(Cl)C([H])=C([H])C([H])=C3[H])[C@@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C(C([H])=C(S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C2=NC(=C([H])C(=C2N=C1C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C(C([H])=C([H])C([H])=C1[H])N(C(=O)C([H])([H])[H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N([H])[H])C(=O)N([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([H])(O[H])O[H])C(SSC1(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1OC([H])([H])C(=O)O[H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)O[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=NC([H])=C(C([H])=C2C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2=NC(C3=C([H])C([H])=C([H])C([H])=C3F)=C(C([H])=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=NN=C2N1C1=C([H])C(F)=C(F)C([H])=C1N=C2N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(C(=O)N([H])C2=C([H])N=C(N=C2[H])N([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(N=C1N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C(C([H])=C1[H])C1=NC(SC([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])=C(C#N)C([H])=C1[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2C2=C1C([H])=C([H])S2)C1=NN=C([H])N1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C(=O)N(C([H])([H])C(=O)N(C([H])([H])C(=O)N([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N([H])[H] [H]O[C@]1([H])C([H])([H])O[C@@]([H])(N([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)N([H])[H])[C@@]([H])(O[H])[C@]1([H])O[H] COC1=CC=C(OC2=C(Cl)C=NN(C2=O)C2=NC3=C(C=CC=C3)C(=O)C3=C2C=CC=C3)C=C1 [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1OC(F)(F)F [H]N1C2=C(C3=C1C1(C([H])([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])N([H])C3=O)C([H])([H])C([H])([H])C1=C2N=C(N=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]OC(=O)C([H])([H])N1N=NC(=N1)C1=C([H])C([H])=NC(=C1[H])C1=C([H])N(N=N1)C([H])([H])C1=C([H])C(Cl)=C(Cl)C(Cl)=C1[H] [H]C1=C(C(=O)C([H])([H])N2C([H])([H])C([H])([H])C([H])(N3C(=NC4=C3C([H])=C([H])N=C4[H])C([H])([H])[H])C([H])([H])C2([H])[H])C2=C(Cl)C([H])=C([H])C([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])OC2=C([H])C([H])=NC(=N2)N2C([H])([H])C([H])([H])N(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1([H])[C@]([H])(O[C@@]([H])(C2=C([H])C(=C(Cl)C([H])=C2[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])C([H])=C([H])O2)[C@]([H])(O[H])[C@@]1([H])O[H])C(=O)C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12 [H]N(C(=O)C1=NC([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(Cl)=C1[H] CC(C)OC(=O)C1=C(O)C=CC(O)=C1 NC1=CC=C(C=C1)S(=O)(=O)NCCC(F)Cl [H]OC(=O)[C@]1([H])N(C(=O)[C@@](N([H])C(=O)ON2[C@@]3([H])C([H])([H])[C@@]4([H])C([H])([H])[C@]2([H])C([H])([H])[C@@]([H])(C3([H])[H])C4([H])[H])(C([H])([H])[H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]([H])(OC2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1([H])[H] [H]OC1=C(C2=NC3=C([H])C([H])=C([H])N([H])C3=N2)C(N([H])[H])=C2C([H])=C([H])C([H])=C([H])C2=N1 [H]N1\C(SC([H])([H])C1=O)=C(\[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] OC(=O)CCC1=CC=C(NCC2=C(C=CC=C2)C2=CC=CC=C2)C=C1 [H]N([H])C1=C(C(=NC([H])=N1)C#CC1=C([H])N=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])OC([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=NN1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])C1=C(C(=C2N1C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C(=C([H])C([H])([H])C1([H])[H])C(=O)N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(N=C1C([H])([H])N(C([H])([H])[H])[C@@]1([H])C3=NC([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C1([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC(=O)[C@]([H])(OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(OC2=NC3=C([H])C(Br)=C([H])C([H])=C3C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C(N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OP(=O)(O[H])C([H])(N([H])C1=C([H])C(=C([H])C([H])=N1)C1=C([H])C2=C(N([H])N=C2[H])C([H])=C1[H])P(=O)(O[H])O[H] [H]OC1=C([H])C(=C([H])C(O[H])=C1[H])[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)OC([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1O[H] [H]OP(=O)(O[H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]1([H])C(=O)N2N(C(=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=NC2=C(S1)C([H])=C(N([H])C(=O)C([H])([H])N([H])C([H])([H])[H])C([H])=C2[H] [H]N(C1=NC(=NC2=C(C(=NN12)C([H])([H])[H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C(=NC3=C2N=C([H])N=C3SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]N(C(=O)C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=NC([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C(N=C1C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1F)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C(=O)C2=C([H])C(=O)C3=C([H])C([H])=C(F)C([H])=C3O2)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=NN(C([H])=C1C1=C([H])C([H])=NC2=C1C([H])=C([H])N2[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C1=C([H])N(N=N1)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)C([H])([H])[H] [H]C1=C([H])N(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1N=NC2=C([H])C([H])=C(Cl)C([H])=C2C1=O [H]N([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[C@]2([H])SC2([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)[C@]1([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C([H])=C([H])C([H])=C2N2N=C(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@@]1([H])OC([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1F [H]N(C(=O)C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(S1)S(=O)(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N1C(=O)C2=C([H])C([H])=C([H])C(N3C([H])([H])C([H])([H])N(C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])C3([H])[H])=C2C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]12C([H])([H])[C@]3([H])C([H])([H])[C@]([H])(C1([H])[H])C([H])([H])[C@@](C3([H])[H])(C2([H])[H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])C#N)C([H])([H])C([H])([H])[H] FC1=C(C=CC=C1)S(=O)(=O)N1C(=CC2=CC=CC=C12)S(=O)(=O)N1CC(CCNS(=O)(=O)C(F)(F)F)C1 [H]N(C(=O)[C@@](N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C(N([H])S(=O)(=O)C([H])([H])[H])=C1[H])(C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C1=C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=C(C([H])=C([H])C(=C1[H])C(=O)N([H])C([H])([H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)N([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])C([O-])=O)C([H])([H])[C@]([H])(O[H])C([H])([H])C([H])([H])C1=C(C(=NN1C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C([H])=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1=O [H]N(C(=O)C1([H])C([H])([H])C1([H])[H])C1=NC(C2=C([H])C([H])=C(O2)C([H])([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])=NC([H])=C1[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2C2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]N(C(=O)[C@]1([H])C([H])=C2C3=C4C(=C([H])C([H])=C3[H])N(C([H])=C4C([H])([H])[C@@]2([H])N(C([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C(N([H])C([H])([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(OC([H])([H])C([H])([H])[H])=C(C(OC([H])([H])C([H])([H])[H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C(OP(=O)(OC(=O)C([H])([H])[H])OC(=O)C([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)C([H])([H])[C@@]1([H])N(C([H])([H])C([H])([H])N([H])C1=O)S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@@]1([H])C2=C(OC([H])([H])C1([H])[H])C([H])=C(C([H])=C2[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC(Cl)=C1C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C([H])C([H])=C1C1=NC(N([H])C(=O)C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])=C(C#N)C(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C2OC([H])([H])C([H])([H])OC2=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C(N=C(O1)C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C#N)C([H])([H])[H] [H]OC1=C(C([H])=C([H])C(OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])SC2=C([H])C([H])=NC([H])=C2[H])=C1C([H])([H])[H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C2C3=C1C(=O)C(=O)C3=C([H])C([H])=C2[N+]([O-])=O)[N+]([O-])=O COC(=O)C1=CC=C2C(N\C(\C\2=N\O)=C2/C(=O)NC3=C2C=CC=C3C(F)(F)F)=C1 [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(OC([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C(=C([H])C([H])=C2[H])C(=O)OC([H])([H])C([H])([H])[H] [H]OC1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N(C2=NC(=C3C([H])=C(N([H])C(=O)C([H])([H])OC4=C([H])C([H])=C(OC(F)(F)F)C([H])=C4[H])C([H])=C([H])C3=N2)C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC2([H])C([H])([H])N(C(=O)N(C3=C([H])C([H])=C(OC([H])([H])[H])N=C3[H])C([H])([H])[H])C2([H])[H])=C(C(F)=C1[H])C([H])([H])[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])[C@@]([H])(N(C(=O)C([H])([H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(SC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])[N+]([O-])=O)N=C([H])N=C2N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC([H])([H])C1(C([H])([H])N([H])C(=O)C2=C([H])C3=C([H])C(C#N)=C([H])C([H])=C3N2C([H])([H])C2=C([H])C(=C([H])C([H])=C2OC([H])([H])[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]SC([H])([H])[C@]([H])(N([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C(=O)C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])OC1([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC(=NS2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=NC([H])=N1 [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]N([H])C1=C2N=C(N(C2=NC(F)=N1)C([H])([H])C([H])([H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C(I)C([H])=C2OC([H])([H])OC2=C1[H] [H]C1=C(C(=O)C2(O1)C([H])([H])C([H])([H])N(C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C1F)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N(C(=O)C2=C1C(=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])[C@@]2([H])C3=C([H])C([H])=C([H])C(OC([H])([H])[H])=C3C([H])([H])C([H])([H])[C@@]2([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1N([H])[H])[C@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2N=C([H])N(C2=NC([H])=N1)[C@]1([H])O[C@]([H])(C([H])([H])O[H])[C@@]([H])(O[H])[C@@]1([H])O[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(SC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2OC([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C2=C1C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C1=NC2=C(C(=N1)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C2[C@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]2([H])O1 [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] C=CC(=O)NC1=CC=C(C=C1)S(=O)(=O)N1CCN(CC1)C(=O)N1CCCC2CCCCC12 [H]N=C(N([H])[H])C1=C([H])C2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])[C@@]1([H])C([H])([H])[C@]1([H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])N=C2C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])[C@]([H])(C(=O)OC([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])SC([H])=N1)C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] COCCN(CC1=CC=CC(OC)=C1)C(=O)NC1=CC=C(C=C1)C1=CNN=C1 [H]N1N=C([H])C2=C1C(=C([H])C(=C2[H])C(=O)N1C([H])([H])C([H])([H])C2(OC3=C(N(N=C3C(=O)C2([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NN=C1S(=O)(=O)C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C(F)(C([H])([H])OC2=C([H])C(F)=C([H])C3=C([H])C([H])=C(N=C23)C2=NN=C3C([H])=C([H])C([H])=C([H])N23)C([H])([H])C1([H])[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2O1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])F)=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C1=C([H])C(C(=O)N([H])C2=C([H])C([H])=C(Cl)C([H])=N2)=C(N([H])C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C([H])=C([H])C([H])=C2[H])S(=O)(=O)N([H])[H])C([H])=C1[H] [H]N1C([H])=C(\C([H])=C2\N(\C(=N\C([H])([H])[H])N([H])C2=O)C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1(C([H])([H])S[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=NN=NN2C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C1=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)N(=O)=O)C(=O)OC1CCCN(CC2=CC=CC=C2)C1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])O[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]N(C1=NC2=C(C([H])=C(C([H])=C2N=N1)C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C([H])C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C(C#N)C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC(=NC2=C1C([H])=NN2C([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(S1)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])N2[H] [H]C1=NN(C([H])=N1)C1=C([H])C(Cl)=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(F)C([H])=C2C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N([H])C1=NC2=C(OC3=NC([H])=C(Cl)C([H])=C23)C(=N1)N1C([H])([H])C([H])([H])[C@@]([H])(N([H])[H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])N1C([H])([H])C([H])([H])N([H])C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])S1(=O)=O [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1O[H])S(=O)(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C(=O)C(=C([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1(N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C#N [H]N([H])C1=C([H])C2=NC([H])=NC(N([H])C3=C([H])C([H])=C([H])C(=C3[H])[N+]([O-])=O)=C2C([H])=N1 [H]O[C@@]([H])(C([H])([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N1C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C([H])C([H])=C12 [H]N=C(N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C(=O)[C@]1([H])C(=C([H])C([H])([H])C1([H])[H])C(=O)N(C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(F)C(=C(F)C(=N2)N([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C(OC([H])([H])C([H])([H])[H])C([H])=C(\C([H])=C(\[H])[N+]([O-])=O)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]OC(=O)[C@]([H])(SC1=NN=C(N1C([H])([H])[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H])C([H])([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C([H])([H])C(=O)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C(F)(F)F [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(OC([H])([H])[H])C([H])=C(C([H])=C3[H])C3=NC4=C(S3)C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])=C2C([H])([H])C1([H])[H] O=C(CCC1=CC=CC=C1)NC1=CC=C(C=C1)C1=CNN=C1 [H]OC1=C([H])C([H])=C2C(SC(=C2OC2=C([H])C([H])=C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C2=C([H])C([H])=C(N([H])[H])C([H])=C2[H])=C1[H] [H]N1C([H])=NC2=C(I)C(I)=C(I)C(I)=C12 NS(=O)(=O)C1=CC(=CC=C1)C1=CC(NC2=CC=C(OC(F)(F)F)C=C2)=NC=N1 [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]2([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]3(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])SSC2([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C3([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[H] [H]N([C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N2C([H])([H])C([H])([H])C(C3=NN=C(O3)C([H])([H])[H])(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(F)C(F)=C1N([H])C1=C(F)C([H])=C(I)C([H])=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC1=NC2=C([H])C(=C(N([H])[H])C([H])=C2N2N=C(N=C12)C(=O)OC([H])([H])C([H])([H])[H])[N+]([O-])=O [H]N(N([H])C(=O)C([H])([H])OC1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C(=O)C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])N=C(N([H])C([H])([H])C([H])([H])C([H])([H])C2=NC(=NO2)C([H])([H])[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C(=C([H])C([H])([H])[C@]1([H])C([H])([H])[H])C1=NN(N=N1)C([H])([H])[H] [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1OC1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)N(C([H])([H])[H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C([H])C(=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C([H])=O)C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N1C([H])([H])C([H])([H])C2(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C2=O)C([H])([H])C1([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@@]1([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C2=C([H])N([H])C([H])=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(OC([H])([H])C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1([H])[H])N([H])[H] [H]O[C@@]1([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C(=N1)N([H])[H] [H]N(C(=O)C([H])([H])[H])C1=NC(=C(C(=O)N2C([H])([H])C([H])([H])C(N3C([H])([H])C([H])([H])C([H])(C(=N/OC([H])([H])C([H])([H])[H])\C4=C([H])C([H])=C(Br)C([H])=C4[H])C([H])([H])C3([H])[H])(C([H])([H])[H])C([H])([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2N=C1C([H])([H])Br)C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(\N=C(/[H])C1=C([H])C([H])=C([H])S1)C1=NC2=C([H])C([H])=C([H])C([H])=C2S1 [H]O[C@@]([H])(C([H])([H])[H])[C@]([H])(N1C([H])=NC2=C(N=C([H])N=C12)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=NC(=O)C1=C(N([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H])N([H])[H] [H]N(C(=O)C1=C(N(N(C1=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])SC(=N1)C([H])([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=NC3=C([H])C(OC([H])([H])[H])=C([H])C([H])=C23)C([H])=N1 [H]N1N=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C(=NN1C([H])([H])[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]OC(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C1=C(Cl)C([H])=C([H])C([H])=C1C(F)(F)F [H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])SC1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C(F)(F)F)C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C2=C(C(=NN12)C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] CC1=CC=C(C=C1)C(=O)CC(NC1=CC=C(C=C1)N(O)=O)C1=CC=CC=C1 [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])=C(O2)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C([H])([H])N1N=C(C([H])=C1C([H])([H])[H])C1=NC2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] ON(=O)C1=C(C=CC=C1)C(=O)NC1=C2N=NN(CC3=CC=CC=C3)C2=NC(=N1)C1=CC=CC=C1 [H]N(C1=NC(=NC2=NC([H])=C(C([H])=C12)C1=C([H])N(N=C1[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C(F)(F)F)C([H])([H])C1=C([H])C(C#N)=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]OC([H])([H])[C@]([H])(O[H])C([H])([H])C1=C([H])C(N([H])C([H])([H])C2=C([H])N([H])C([H])=N2)=C([H])C2=C(N([H])C3=C([H])C([H])=C(F)C(Cl)=C3[H])C(C#N)=C([H])N=C12 [H]N(C1=NC2=C(N=NN2C2=C1SC([H])=C2[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC(=O)C1([H])C([H])([H])N(C1([H])[H])[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C3=C(OC4=C(C([H])=C([H])C([H])=C4[H])C2([H])[H])C([H])=C([H])C([H])=C3[H])C1([H])[H] [H]C1=C([H])C(=C2C(=O)N(C([H])([H])OC(=O)C3=C(Cl)C([H])=C([H])C(OC([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C3Cl)S(=O)(=O)C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=NC([H])=NC2=C1C([H])=C(OC([H])([H])[H])C(OC([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C2[H])C1=C(F)C([H])=C(Cl)C([H])=C1[H] [H]N1C(=S)N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2[H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N(C1=NC([H])=NC(=C1C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC([H])([H])C([H])([H])[C@@]([H])(N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C(C([H])=C23)N2C([H])=NN=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C2C([H])=C([H])N(C2=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=NN=C(SC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])N1[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N(C(=O)C([H])([H])C1=C(F)C(F)=C([H])C([H])=C1[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])[C@]1([H])O[C@@]([H])(C([H])([H])C([H])([H])C2=C([H])C(=C(F)C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C2=C3N=C(C([H])=C([H])C3=C([H])C(OC([H])([H])[H])=C2C2=C([H])C(=C([H])C([H])=C2S1(=O)=O)C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C(C#N)=C([H])C(=C1[H])C(=O)C([H])([H])Br [H]OC([H])([H])[C@]1([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]([H])(O[C@@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])[H])C(=O)N([H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=C1[H])C(=O)N([H])[H])C([H])([H])[H]