[H]N(C(=O)C1=C([H])C([H])=C(N=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])C([H])([H])N(C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])/C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1F)N1C([H])=NC2=C1C([H])=C([H])C(=C2[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])O[H])C1([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N([H])S(=O)(=O)C1=NN(\C(S1)=N\S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C2=NC(=NC(C3=C([H])C([H])=C(Cl)C([H])=C3[H])=C2C([H])=C1Cl)C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C(=O)[C@@]1(OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])C([H])([H])C4=C([H])C(=O)C([H])=C([H])[C@]4(C([H])([H])[H])[C@@]3(F)[C@@]([H])(O[H])C([H])([H])[C@]12C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(N([H])S(=O)(=O)C4=C([H])C([H])=C(Cl)C([H])=C4[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N([H])C1=NN=C(O1)C1=C(C([H])=C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])=C1[H])[C@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@@]1([H])C2([H])[H] [H]C1=C(SC2=C1N=C([H])N(C2=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]C1=C([H])N(\C(S1)=N\C(=O)C([H])([H])Cl)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]C1=C([H])C([H])=C2C(C([H])=C([H])C([H])=[N+]2C([H])([H])C([H])([H])C([H])([H])[N+]2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] [H]N(C(=O)C1=C([H])N=C([H])C(\C([H])=C(/[H])C2=C(Cl)C([H])=C([H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3[H])C3=C([H])C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C(/[H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])[N+]([O-])=O [H]N1C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C([H])([H])C([H])([H])OC2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON(C(=O)[C@@]([H])(OC1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C(N2C([H])=C(C([H])=C([H])C2=N1)C(=O)C1=C([H])C([H])=C([H])C([H])=C1Cl)C(=O)C1=C(F)C([H])=C([H])C([H])=C1F [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C1=C(C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=NN2C(=C1[H])C(=O)N(C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC(=O)C1=C(C(=O)C2=C(O[H])C([H])=C(C([H])=C2O[H])C(=O)OC([H])([H])[C@@]([H])(N([H])S(=O)(=O)C2=C([H])C3=C(C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(O[H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[C@]([H])(O[H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])C4=C([H])C([H])=C(O[H])C([H])=C4C([H])([H])C([H])([H])[C@@]3([H])[C@]12[H] [H]O[C@]([H])(C([H])([H])N1N=C(C2=C1C([H])([H])C([H])([H])N(C(=O)C1=C([H])C([H])=C([H])S1)C2([H])[H])C1=C([H])C([H])=C(C(SC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(F)C([H])([H])C2([H])[H])=C1[H])C(F)(F)F)C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C(=O)N([H])[H] [H]N(C(=O)N([H])C([H])([H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C1=NN=NN1C([H])([H])[H])C([H])([H])C([H])([H])[H] [H][C@@]12C[C@]1([H])[C@H]([C@H](O)[C@@H]2O)N1C=NC2=C1N=C(N=C2NCC(C1=CC=CC=C1)C1=CC=CC=C1)C#CC1=CC=CC=C1Cl [H]N1C(=S)N(C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C(Cl)=C(F)C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Br)O1)C1=C([H])C([H])=C([H])C(Cl)=C1N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N1C(=O)C2(N(C3=C([H])C([H])=C([H])C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C1=C([H])C(F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H])C1=NC([H])=C(S1)C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C(F)(F)F [H]OC([H])([H])[C@]([H])(N([H])C1=NC(SC([H])([H])C2=C(F)C(Cl)=C([H])C([H])=C2[H])=NC2=C1SC(=N2)N([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])[C@@]([H])(C([H])([H])[H])C([H])([H])N1C([H])=C([H])C2=C([H])C([H])=C3N=C([H])C([H])=C([H])C3=C12 [H]N([H])C1([H])C([H])([H])C([H])([H])N(C2=C3N=C([H])N([H])C3=NC([H])=N2)C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C1=C2C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]OC([H])([H])[C@]1([H])O[C@]([H])(N2C([H])=NC3=C(N=C([H])N=C23)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@@]([H])(O[H])[C@@]1([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])N(C2=NC(=C([H])C(=O)N12)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C([H])=C([H])C(Br)=C3[H])C2=C1[H] [H]C1=C(C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(N=C1N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C(=C([H])C([H])=C23)C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])OC1=C(C([H])=C(N([H])C(=O)C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=NN1C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=C1[H])C([H])([H])N([H])C(=O)C1=C([H])C([H])=C(S1)C([H])([H])C([H])([H])C(=O)N([H])C1=NC([H])([H])C([H])([H])C([H])([H])N1[H] [H]OC(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]N(C(=O)C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C(\[H])=C(/[H])C1=C([H])C(=C([H])O1)C([H])([H])C1=C([H])C2=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C2N=C(OC2=C1[H])C1=C2C([H])=C([H])C(O[H])=C(Br)C2=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3(C([H])([H])C2=O)C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C([H])=C24)C([H])([H])C3([H])[H])=C1[H] [H]N(C(=O)C([H])([H])[C@]1([H])N(C([H])([H])C([H])([H])N([H])C1=O)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]1([H])C2=C(C([H])=C(C([H])=C2[H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])[C@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C(=N[C@]([H])(C1=O)C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F [H]C1=C([H])N2N=C(N=C2C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])C1([H])[H] [H]C1=C([H])N2C(Br)=C(N=C2C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2Cl)=C1[H])C([H])([H])[H] [H]OC(=O)[C@@]1([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]([H])(N([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])O[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@]([H])(OC([H])([H])C1=C([H])C([H])=C(C#N)C([H])=C1[H])C1=C([H])C(=C(C#N)C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C(F)(F)F [H]C1([H])OC([H])([H])C([H])([H])N(C([S-])=S)C1([H])[H] [H]C1=NC(SC([H])([H])[H])=NC2=C1C(=O)C([H])([H])[C@]([H])(C([H])([H])N1C([H])([H])C([H])([H])C([H])(C(=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C1([H])[H])C2([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C(=O)C([H])([H])C([H])([H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC(=NC(=C2[H])C(F)(F)F)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] C\C(=N/OCC1=CC(=C(C=C1)C1=CC=CO1)C(F)(F)F)C1=CC=C(CNCCC(O)=O)C=C1 [H]C1=NC2=C(N=C(N2[C@@]2([H])C([H])([H])C3([H])N(C([H])([H])C([H])([H])[C@]([H])(C(=O)OC([H])([H])[H])C4=C([H])C([H])=C([H])C([H])=C4[H])[C@]([H])(C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])[H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(N([H])[H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C1C2=O [H]N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C2O[C@@]3([H])C4=C(C5=C(N4C([H])([H])C4=C([H])C([H])=C([H])C([H])=C4[H])C([H])([H])C([H])([H])C([H])([H])C5([H])[H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)C1=C([H])N=C(Cl)C(Cl)=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1\C(S\C(=C(\[H])C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C1=O)=N\C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]1(C2=C([H])C(F)=C(F)C([H])=C2[H])C([H])([H])C([H])([H])N([H])C([H])([H])[C@]1([H])C(=O)N(C([H])([H])C1=C([H])N(C2=C1C(F)=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1([H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C(S1)S(=O)(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])[C@]1([H])N(C(=O)C([H])([H])[C@]1([H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]OC1=C2N=C(N(C2=C([H])C([H])=C1OC([H])([H])[H])C1=NC(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])(F)F [H]C1=C([H])N(C([H])=N1)C1=NN(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=NN(C2=C1C([H])([H])C([H])([H])C1=C([H])N=C(N=C21)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(F)(F)F [H]N(C1=NC(=C([H])S1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])N=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])C1=C([H])C(Cl)=C([H])C([H])=C1C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])ON1C(=O)C([H])([H])S[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(C(=O)O[H])C1=C([H])C(C2=NC3=C([H])C(=C([H])C([H])=C3N2[H])C(=N[H])N([H])[H])=C(O[H])C(=C1[H])C1=C([H])C([H])=C([H])C(O[H])=C1[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])N1C(=C([H])C2=C([H])C(F)=C([H])C([H])=C12)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C([H])C(Cl)=C1[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] [H]N1[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C#N)C([H])([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])SC([H])([H])C2([H])[H])[C@]1([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(Cl)C(=N1)N1C([H])([H])[C@]([H])(N(C([H])([H])[C@]1([H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(Cl)=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]\C(C#CC1=C(F)C([H])=C([H])C(F)=C1[H])=C1\C([H])([H])N2[C@]3([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]([H])(C(=O)OC([H])([H])[H])[C@@]1([H])C3([H])[H] [H]OC1=C([H])C([H])=C2N([H])C3=C(C2=C1[H])C1=C(C(=O)N([H])C1=O)C(=C3[H])C1=C(C([H])=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=NC([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]N1N=C2C3=C(SC(=C3C([H])([H])C([H])([H])C([H])([H])C2=C1[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]1([H])C([H])([H])C(=O)O[C@]([H])(C([H])([H])C([H])([H])N2C(=C([H])C([H])=C2C([H])(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1F)N(C([H])([H])C#C[H])C([H])([H])C1=C(C([H])=C2N=C(N=C(O[H])C2=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(=N1)C1=C([H])C([H])=C(C([H])=C1[H])[S@](=O)C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C(=O)[C@]1(N([H])N=C(C1([H])[H])C(F)(F)F)C([H])([H])[H])C1=C([H])C([H])=C(C#N)C(=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])[C@@]1(OC([H])([H])C([H])([H])C2=C1N([H])C1=C(C([H])=C([H])C([H])=C21)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N(C1=C([H])C([H])=NC2=C1C1=C([H])C([H])=C([H])C([H])=C1N2[H])C([H])([H])C([H])([H])OC([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C([H])([H])C1=C(O[H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)O[C@@]1([H])[C@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])N=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C([H])C(=C1[H])C1=NN2C(SC1([H])[H])=NN=C2C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C(OC([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C([H])C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] COCCCC1=CC(NC2=NC(NCC3=CC(=NO3)C(N)=O)=NC=C2)=NN1 [H]OC(=O)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC(=NC2=C1N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(O[H])C([H])=C(\C([H])=C(/[H])C(=O)C2=C(OC([H])([H])[H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1N([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C(=O)C([H])([H])[H] [H]N(C1=C2C([H])=NN(C2=NC([H])=N1)C([H])([H])[C@]([H])(Cl)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H] [H]N1C(SC([H])([H])C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC2=C1C([H])=C([H])C(=C2[H])C([H])([H])[H] [H]C1=C([H])C([H])=[N+](C(=C1[H])C([H])([H])N(C(=O)OC([H])([H])[C@]1([H])C([H])([H])O[C@@]([H])(OC([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1([H])[H])C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=NN([H])C2=C1C([H])=C([H])C(=C2[H])C1=C([H])C(=NC(=N1)N([H])[H])N1C([H])([H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(\C([H])=C(/[H])C2=C(Cl)C([H])=C(OC([H])([H])C3=C(ON=C3C3=C(C([H])=C([H])C([H])=C3F)C(F)(F)F)C([H])([H])C([H])([H])[H])C([H])=C2[H])=C1[H] [H]OC1(O[H])C([H])([H])[C@]2([H])N([C@@](C([H])([H])[H])(C([H])([H])C2([H])[H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(C2=C([H])C([H])=C(Cl)C(=C2[H])C([H])([H])C2=NC([H])=C(S2)C2=C([H])SC([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)[C@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])([H])[C@]3([H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(O[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]4([H])C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@]1(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]OC(=O)C1=C(C([H])=C([H])C(O[H])=C1[H])N1C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C([H])C(=C([H])S1)[C@]1([H])OC2=C(N=NC(SC([H])([H])[H])=N2)C2=C(C([H])=C([H])C([H])=C2[H])N1C(=O)C([H])([H])[H] [H]C1=NN=NN1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(F)=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]N([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C2=C(N([H])C3=C2C([H])=C(Cl)C([H])=C3[H])[C@]1([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C#CC([H])([H])OC([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(OC([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N\OC([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)C([H])([H])[H])C([H])=C1[H])\C([H])([H])[H] [H]N(C(=O)C1=C([H])C(=NO1)C1=C([H])C([H])=C([H])C([H])=N1)[C@]([H])(C(\[H])=C(/[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] COC1=CC(=CC=C1OCCN1CCCC1)N1CC2=CC=C(SC3=CC(Cl)=C(F)C=C3)N=C2C1=O [H]O[C@@]([H])(C([H])([H])[C@@]([H])(OC([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C(=C([H])C(=C1[H])C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N(C([H])([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])OC1=C([H])C(F)=C([H])C(F)=C1[H] [H]C1=C(N=C(S1)N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C([H])C(Cl)=C(N([H])C([H])([H])[H])C([H])=C1OC([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]OC(=O)C([H])([H])N1C(SC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=NC2=C([H])C([H])=C([H])C([H])=C12 [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H] [H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])N(C3=C(Cl)C(Cl)=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])N=C([H])C([H])=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=NN2N=C(C(=C12)C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]\C(OC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])=C1\C([H])([H])[C@@]2([H])N(C([H])([H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] CCCCC(NC(=O)OCC1(CCC1)C1=CC=C(F)C=C1)C(=O)C(=O)NC1=CC=NN1 [H]N(C(=O)N1C([H])([H])C(=O)C([H])([H])[C@]1([H])C(=O)N([H])C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]C1=NC2=C(C([H])=C1[H])N1C(=NC(=C1C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])N2C1=C(Cl)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2C(N=C([H])N=C2N2C([H])([H])C([H])([H])N(C(=O)N([H])C3=C([H])C([H])=C(OC4=C([H])C([H])=C([H])C([H])=C4[H])C([H])=C3[H])C([H])([H])C2([H])[H])=C1[H] [H]C1=NC(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])N(C2=C([H])C(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C([H])([H])[C@@]1([H])O[C@@]([H])(C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F)C([H])([H])[H] [H]OC(=O)[C@@]1([H])N([H])C2=C(C([H])=C(C([H])=C2[H])C(=O)C([H])([H])[H])[C@@]2([H])C([H])=C([H])C([H])([H])[C@@]12[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C1=C(C#N)C([H])=NC2=C([H])C(C#CC3=C([H])C([H])=C([H])N=C3[H])=C([H])C([H])=C12 [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)N(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(O[H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1C(=O)N(C(=O)C1([H])[H])S(=O)(=O)C1=C([H])C(=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N(C(=O)C(N([H])C(=O)N2C([H])([H])C([H])([H])C([H])(N3C(=O)N([H])C4=C3C([H])=C([H])C([H])=N4)C([H])([H])C2([H])[H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1C#N)[C@@]1([H])OC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[H])[C@]1([H])C([H])([H])C2([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C2=C3C(=C([H])C(=O)C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2([H])[C@]2([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC([H])([H])[H])[C@@]2(C([H])([H])[H])C1([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(OC([H])([H])[H])=C2C(=N1)C([H])([H])OC2([H])[H])C(OC([H])([H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] CC1=CC=CC=C1OC1=CC=C(CN(CC2=CC(F)=CC(F)=C2)C2=C(Br)C=C(CC(O)=O)C=C2Br)C=C1 [H]OC(=O)[C@@]1([H])N(C([H])([H])C([H])([H])[C@]2(C(=O)C3=C([H])C(OC([H])([H])[H])=C(Cl)C(Cl)=C3C2=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(SSC2=C(C(=O)N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C(C([H])=C([H])C([H])=C3[H])N2C([H])([H])[H])N(C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=NC2=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C(OC([H])([H])[H])C([H])=C12)C1=C([H])C([H])=C([H])C2=C1OC([H])([H])O2 [H]C1=NOC(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])OC([H])([H])C([H])([H])N([H])C(=O)C([H])([H])N1C(=O)C(=NC([H])=C1C([H])([H])[H])N([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C3=C([H])C([H])=C4C([H])=C([H])C([H])=C([H])C4=C3[H])C([H])([H])SSC2([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C2=C([H])C([H])=C(N([H])C(=O)N([H])[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[N+]([O-])=O)C([H])([H])C([H])([H])N(C([H])([H])C(=O)O[H])C([H])([H])C1([H])[H] [H]N1C(=C(C(=O)C(=O)N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C(Cl)=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2OC([H])([H])[C@@]3([H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])OC([H])([H])[C@]3([H])C2=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])N1N=NN=C1S[C@@]1([H])C(=O)N(C(=O)C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]ON([H])C(=O)C1=C([H])N=C2C(I)=C([H])C([H])=C([H])C2=C1N(C([H])([H])C1=C([H])C([H])=C([H])N=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])N=C1[H])C([H])([H])C1=C([H])SC(=N1)C([H])([H])C([H])([H])C([H])([H])C1=NC2=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])C([H])([H])N2[H] [H]O[C@@]1(N2C(=NC(C([H])([H])[H])(C([H])([H])[H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H] COC1=C(OC)C=C(C=C1)C1=NC(=NO1)C1=C2NC=C(CCC(O)=O)C2=CC=C1 [H]OC([H])([H])[C@@]1([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])[C@]([H])(O[H])[C@@]([H])(O[H])[C@]1([H])O[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])C1=C(N([H])C2=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]([H])(OC1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])S(=O)(=O)C1=NN=C(S1)N([H])C(=O)N([H])C1=C(F)C(F)=C(F)C(F)=C1F [H]OC(=O)C1=C([H])C([H])=C2C3=C(C([H])=C([H])S3)C(=O)N([H])C2=C1[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])N2\C(=N/C#N)N(C3=C(C(Cl)=C(C#N)C([H])=C3[H])C([H])([H])[H])[C@@]([H])(C([H])([H])[H])[C@]12[H] [H]N1C([H])([H])C([H])([H])C([H])(N2C([H])=NC(=C2C2=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC([H])=C2[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C(O[H])=C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])OC([H])([H])[H])C([H])([H])OC([H])([H])[H])C([H])([H])[C@@]4(O[H])[C@]([H])(N(C([H])([H])C5([H])C([H])([H])C5([H])[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(N2C([H])=C([H])C([H])=C2[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N1C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C([H])C([H])=C3[C@]2([H])[C@]1([H])C([H])([H])C([H])([H])[H])C(F)(F)F [H]OC([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NC(C2=C([H])C([H])=C(F)C([H])=C2[H])(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])N1[H] [H]N(C1=NC2=C(N=C(S2)N2C([H])([H])C([H])=C([H])C([H])([H])C2([H])[H])C2=C1N=C([H])N2C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C(=O)C1=C([H])C([H])=C(C(=C1[H])C(F)(F)F)C1([H])C([H])([H])C([H])([H])N(C(=O)C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N1C([H])([H])[C@]([H])(C2=C([H])C(F)=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])C(=NN3C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1F)[C@]([H])(C(=O)N([H])[C@]([H])(C#N)C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N(C1=NC(N([H])C2=C([H])C([H])=C([H])C([H])=C2C#N)=C2C([H])=C([H])N([H])C2=N1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(Cl)=C(N2C([H])=C([H])S[C@]12[H])S(=O)(=O)C1=C([H])N(C2=NC([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NOC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(OC(F)(F)F)=C1[H] [H]OC([H])([H])C1([H])C([H])([H])N(C([H])([H])C2=C([H])N([H])C3=C2N=C([H])N([H])C3=O)C1([H])[H] [H]C1=C([H])N(C(=N1)C([H])([H])N1C([H])([H])C([H])([H])C2(C(=O)N(C3=C([H])C([H])=C([H])C([H])=C23)C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C2OC([H])=C(C2=C([H])C([H])=C1[H])C([H])([H])C([H])([H])SC([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C(N([H])C(=C1[H])C1=NC([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C(Cl)=C2Cl)C([H])([H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N(C(=O)C1=C([H])C2=C(OC([H])([H])C2([H])[H])C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C1([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1N=C(OC1=S)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]([H])(N([H])C1=C(C([H])=NC([H])=C1[H])S(=O)(=O)N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])F)C([H])([H])C1([H])[H])C1=C([H])SC([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O\N=C1/C(=O)N(C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3N2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])N(N=C(C2=C([H])C([H])=C(C(=C2[H])C([H])([H])[H])C([H])([H])[H])C1([H])[H])C(=S)N([H])[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C([H])C([H])([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C12)C1=C([H])C([H])=C(F)C(F)=C1[H] [H]O[C@@](C(=O)N([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])C([H])([H])C(F)(F)C1([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])SC2=NC([H])=C([H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1([H])C([H])([H])O[C@@]([H])(N2C([H])=C(C3=C2C([H])=C([H])C([H])=C3Cl)C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]([H])(O[H])[C@@]1([H])O[H] [H]OC(=O)[C@@]1([H])N(C(=O)N2C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(=O)[C@]1([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C(F)(F)F)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])[H])[C@@]1([H])N([H])[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C(=O)OC([H])([H])C([H])([H])[H])C(=O)N(C(=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C([O-])=O [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])C1=C([H])C2=C(C([H])=C([H])C(OC([H])([H])C3=NC4=C([H])C([H])=C([H])C([H])=C4C([H])=C3[H])=C2[H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C(N=C(S1)C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(N([H])S(=O)(=O)C2=C(F)C([H])=C([H])C([H])=C2F)=C(F)C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]O[C@@](C([H])([H])N1C([H])=C(C(=O)C(=C1[H])C([H])([H])[H])C([H])([H])[H])(C([H])([H])C(C1=C2OC([H])([H])C([H])([H])C2=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H])C(F)(F)F [H]OC(=O)C1=NC2=C(C([H])=C([H])C([H])=C2[H])N(C1=O)[C@]1([H])C([H])([H])[C@@]2([H])N([C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C(OC([H])([H])[H])=C(Cl)C([H])=C1Cl)C1=C(C#N)C([H])=NC2=C1SC(=C2[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N1C2=NN(C([H])=C2C(=NC2=C1C([H])=C([H])C(Cl)=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C2C([H])([H])[C@@]([H])(C(=O)OC([H])([H])[H])[C@@]3([H])[C@@]4([H])C([H])([H])C([H])([H])[C@]5(OC(=O)C([H])([H])C5([H])[H])[C@@]4(C([H])([H])[H])[C@@]4([H])O[C@@]4([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H][C@@]12C[C@@H]3C[C@@H](C3(C)C)[C@]1(C)OB(O2)[C@H](CCCCN)NC(=O)CN1N=C(CNC=O)N=C1CC1=CC=CC=C1 [H]O[C@@]1(C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C([H])C2=C(C([H])=C(N=C2C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C2C([H])=C([H])C([H])=C([H])C2=C([H])C([H])=N1)C(F)(F)F [H]C1=NC(=C([H])C([H])=C1[H])C1=NN(N=N1)C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] CNC(=O)C1=NC=C(C=C1)[C@]1(O)CCN([C@H]1C)C1=CC(F)=C(C=C1)C#N [H]N([H])S(=O)(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(S1)C([H])=C(C([H])=C2[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C(F)=C(F)C([H])=C1[H] [H]N(C(=O)N1C2=C([H])C([H])=C(C(Br)=C2C([H])([H])C1([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])[C@]([H])(C([H])([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=N[H])N([H])[H] [H]N1C([H])([H])C2=C(Cl)C(Cl)=C([H])C([H])=C2C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C(C([H])=C1C([H])([H])[H])C(C1=C([H])C(=C(OC([H])([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C(=C(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@]([H])(N(C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H])C2([H])[H] [H]N(C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])N(C3=C([H])C(Cl)=C([H])C([H])=C23)C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C2C(=C1[H])N(C([H])=C2C1=C([H])C([H])=C(C#N)C([H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])S(=O)(=O)C([H])([H])[H] [H]O[C@]([H])(C(\[H])=C(/[H])N1C(=C([H])C(=C1C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]OC([H])([H])C([H])([H])C([H])([H])N1C([H])=NC2=C(N=C(N=C12)C#N)N([H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(Cl)=C(Cl)C([H])=C1[H] [H]N(C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(Cl)=C([H])C(Cl)=C1[H] [H]N(C(=O)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])[C@]([H])(C(=O)OC([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(F)=C1[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=NN(C(OC([H])([H])C(=O)C2=C([H])C([H])=C(F)C([H])=C2[H])=C1[H])C([H])([H])[H] [H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C(Cl)C([H])=C([H])C(=C3[H])C(F)(F)F)C([H])=C2[H])=C1\C(=N\[C@]([H])(C([H])([H])[H])C([H])([H])O[H])N([H])[H] [H]N=C1O[C@]23OC([H])([H])C(C#N)(C#N)[C@@]1(C#N)[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]ON(C([H])=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=NC([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])\N=C(\N([H])[H])N([H])[N+]([O-])=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](CC[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CC=C1)CC1=CC=CC=C1 [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(Cl)C([H])=C3N(N=C(C(=O)C(=O)N(C([H])([H])[H])C([H])([H])[H])C3=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(C2=C(C([H])=NC(=N2)N([H])C2=C([H])C([H])=C(C([H])=C2[H])N2C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])N1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NC2=C([H])C([H])=C([H])C(C(=O)O[H])=C12)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C([H])([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]C1=NC2=C(C3=C(S2)C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])C(=O)N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])N=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])C1([H])[H] [H]C1=C(N=NN1C([H])([H])C([H])([H])F)C([H])([H])N1C(=O)C(=O)C2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C(=NC3=C2N=C([H])N=C3N([H])C([H])([H])C([H])([H])C([H])([H])[H])N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(O[H])[C@]1([H])O[H] [H]OC(=O)C1=C(OC([H])([H])C(=O)O[H])C2=C(S1)C1=C(S2)C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=NN(C(=O)C([H])([H])[H])[C@@]([H])(O1)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1(C([H])([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C(=O)OC2=C([H])C([H])=C(OC3=C([H])C([H])=C(C([H])=N3)C(F)(F)F)C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C1=C(Cl)C([H])=C(Cl)C([H])=N1 [H]N(C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]1([H])N(C([H])([H])C3([H])C([H])([H])C3([H])[H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H] [H]OC1=NC(=NC(N([H])C([H])([H])C2=C([H])C([H])=C([H])S2)=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H] O\N=C1\C(\NC2=CC=CC=C\12)=C1\C(=O)NC2=C1C=CC(=C2)N(O)=O [H]N1C([H])([H])C([H])([H])C2(OC3=C(C([H])=C([H])C([H])=C3[H])C(=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C(Cl)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])SC(=N2)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C1=NC(=C([H])O1)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]1([H])\C(=C([H])\[C@]([H])(C(=O)C([H])([H])[C@]([H])(OC(=O)[C@@]2([H])N(C(=O)C(=O)[C@]3(O[H])O[C@@]([H])(C([H])([H])C([H])([H])[C@@]3([H])C([H])([H])[H])C([H])([H])[C@]([H])(OC([H])([H])[H])\C(=C(/[H])\C(\[H])=C(/[H])\C(\[H])=C([H])\[C@@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C(=O)[C@]1([H])OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2N=NC([H])=N2)[C@]([H])(OC([H])([H])[H])C1([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])N=C3C([H])=C([H])C([H])=C([H])C3=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1=C2N(N=C([H])N=C2N([H])C2=C([H])C3=C(C([H])=C2[H])N(N=C3[H])C([H])([H])C2=C([H])C(F)=C([H])C([H])=C2[H])C([H])=C1[H] [H]N1C2=C([H])C(OC([H])([H])[H])=C(C([H])=C2C(C(=O)OC([H])([H])C([H])([H])[H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])N=C([H])O1 [H]C1=C(OC2=C1C([H])=C(C([H])=C2[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]N1C2=C(C(=NN2C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C(C1=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] CC(C)C1=CC=C(\C=C2\C(C)=C(CCC(O)=O)C3=CC(F)=CC=C23)C=C1 [H]N1N=C(C2=C([H])C3=C(N2[H])C([H])=C(C([H])=C3[H])C([H])([H])[H])C2=C([H])C([H])=C(C#N)C([H])=C12 [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[C@@]([H])(C(=N\OC([H])([H])C([H])=C([H])[H])\C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(N([H])S(=O)(=O)C2=C(N([H])C([H])([H])C3=C([H])C([H])=NC([H])=C3[H])C([H])=C([H])C([H])=C2[H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C([H])([H])C1=C(N=C(N1C([H])([H])[H])C1=C(F)C([H])=C(F)C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1C([H])([H])[H] [H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]N1N=C(C(=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1N=C2N(C1=S)C1=C(C3=C(S1)C([H])([H])C([H])([H])C3([H])[H])C(=O)N2C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])N1C(=O)C(=NC2=C([H])N=C(N=C12)N([H])C([H])([H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N([H])C(=O)[C@@]1([H])N(C2=NC(=NC(OC([H])([H])[H])=N2)N([H])C2=NC([H])([H])C3=C2C([H])([H])N(C(=O)N([H])[C@@]2([H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])N=C2[H])C2=NC(=NN12)C1=C([H])C([H])=C([H])O1 [H]N(C(=O)C(\[H])=C(/[H])C(=O)N([H])[C@]([H])(C1=NC2=C(C(=C([H])S2)C([H])([H])[H])C(=O)O1)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N1C([H])=C(C2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C(=O)C3=C(C([H])=C(F)C([H])=C3[H])C2=O)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C3N(C([H])([H])C2([H])[H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]2([H])C3=C1[H] [H]O[C@]1(OC([H])([H])C(N([H])[C@@]1([H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C(O[H])/C(=N\C([H])(C([H])([H])[H])C([H])([H])[H])/C\1=N/C1=C([H])C([H])=C([H])C(C(=O)N(C([H])([H])[H])C([H])([H])[H])=C1O[H] [H]C1=NC([H])=C(C([H])=C1[H])C1=NOC(=N1)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(C(=N1)N([H])[H])C(SC1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C2[H] [H]C1=NC([H])=C([H])C(=C1[H])C1=C(N(C(=N1)C1=C([H])C([H])=C(SC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])([H])[H])C1=C([H])C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2C([H])=C1[H] [H]N(C1=NC2=C([H])C([H])=C([H])C([H])=C2C(=N1)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C(=O)C(=C([H])C2=C([H])C([H])=C(C([H])=C12)C([H])([H])[H])[C@@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NN=NN1C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]1([H])C([H])([H])C([H])=C(C2=C([H])N=C(S2)C#N)C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(F)C([H])=C1[H] [H]N(N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1F)C1=C([H])C(Cl)=C([H])C(F)=C1C1=NOC(=N1)C([H])([H])[H])C(=O)C1=C([H])C(OC([H])([H])[H])=NO1 [H]C1=NN(C([H])=N1)C([H])([H])C1=C(N(N=C1C1=NN=C(S1)C1(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)C([H])([H])OC1=C([H])C([H])=C(OC([H])([H])C2=NC(=C(S2)C2=C([H])C([H])=C(OC(F)(F)F)C([H])=C2[H])C2=C([H])C3=C(OC([H])([H])O3)C([H])=C2[H])C([H])=C1C([H])([H])[H] [H]\C(=C(\[H])C1=C([H])C(=C([H])C([H])=C1[H])N(C(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(\C([H])=C(/[H])C2=C(F)C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C(=O)OC([H])([H])[H] [H]C1=C([H])C(=O)N(C1=O)C1=C(C([H])=C(Cl)C([H])=C1[H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1Cl)[P@](=O)(C1=NC2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C2=C(C(=C1[H])C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C([H])C([H])=C1O2)C([H])([H])[H] FC(F)(F)C1=CC=CC=C1OC1=CC=C(C=C1)C1=NC2=CC(=CC=C2N1)C(=O)NCC1=NC=CS1 [H]N([H])C1=NC([H])=NC2=C1C(=C([H])N2C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2Br)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]O[P@]([O-])C([H])([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]ON(C(=O)C([H])([H])SC1=NC2=C([H])C([H])=C([H])C([H])=C2S1)C([H])([H])[H] [H]SC1=NC2=C(Cl)C([H])=C3C(=C2S1)[C@@]1([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C([H])([H])[C@]1([H])N(C([H])([H])[H])C([H])([H])C3([H])[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)C1([H])[H] [H][C@@]12CCCO[C@]1([H])C1=CC(OC3=CC=C(Cl)C=C3)=CC=C1N[C@H]2C1CCCCC1 [H]N1C(=O)C(=O)C2=C1C(Cl)=C([H])C([H])=C2[H] [H]O[C@]([H])(C([H])([H])[H])C([H])([H])N([H])C1=NC2=C(N=C([H])N2C([H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N([H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]C1=C(Cl)C([H])=C(C2=NC(=C3N=NC4=C([H])C([H])=C(OC([H])([H])[H])N=C4N23)C([H])([H])[H])C(Cl)=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])N(C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])OC([H])([H])[H])=C([H])C([H])=C23)C([H])([H])C1([H])[H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C3N([H])C([H])=C([H])C3=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])N([H])C(=O)C(C([H])([H])S[H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@@](O[H])(C#CC4=C(OC5=C(C([H])=C([H])C([H])=C5[H])C4=O)C4=C([H])C([H])=C([H])C([H])=C4[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] [H]N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])N(C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C2([H])[H] Cl.[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)C(N1CC[C@@]4([H])C5=CC=CC=C5CC[C@@]4([H])C1)[C@@]([H])(C2)C3 CC1=CC=C(C=C1)C(SCCN)(C1=CC=CC=C1)C1=CC=CC=C1 [H]N([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C3=C([H])N([H])C4=C3C([H])=C([H])C([H])=C4[H])C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)N1C2=C([H])C([H])=C(Cl)C([H])=C2C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C(OC2=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C([H])C([H])=C3S(=O)(=O)N([H])[H])C([H])=C(Br)C([H])=C2[H])=C([H])C([H])=C1[H] [H]N1N=C(C([H])=C1[H])C1=C([H])C2=C(S1)C1(C([H])([H])N([H])C2=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=NN(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])C1=NC2=C(S1)N=C([H])C([H])=C2[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C1=C2OC([H])([H])[C@]([H])(N1C([H])([H])C(F)(F)F)C([H])([H])C([H])([H])[H])C(F)(F)F [H]N(C([H])([H])C([H])([H])N1C2=C(OC([H])([H])C1([H])[H])C([H])=C([H])C(F)=C2[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C2N=C([H])N(C(=O)C2=C1[H])C([H])([H])C1=C([H])C([H])=C(F)C(Cl)=C1[H] [H]N(C1=NC([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])O[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C(Cl)=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])S1)[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C(=O)C1=NC([H])=C([H])S1 [H]OC(=O)[C@@]1([H])O[C@]2(O[C@](C(=O)O[H])(C([H])([H])OC2=O)[C@]1(O[H])C(=O)O[H])C([H])([H])C([H])([H])C(=C([H])[H])[C@@]([H])(OC(=O)C([H])([H])[H])[C@]([H])(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] CS(=O)(=O)C1=CC=CC=C1C1=CC=C(NC(=O)[C@H]2C[C@@H](O)CN2C(=O)NC2=CC=C(Cl)C=C2)C(F)=C1 [H]N1C2=C([H])C([H])=[N+](C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[N+]2=C([H])C([H])=C(N([H])C([H])([H])C3=C([H])C([H])=C([H])C(=C3[H])C1([H])[H])C([H])=C2[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C([H])([H])N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]OC1=C2C(=NC(=N1)N([H])[H])N([H])C(=C2SC1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C2=C1N(C(=O)C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C2([H])[H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])[C@]2(C1([H])[H])C([H])([H])N(C1=C([H])N=C([H])C([H])=C1[H])C([H])([H])C2([H])[H] [H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C2N([H])C(=C([H])C2=C1[H])C1=C([O-])C(OC2([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(C([H])=C([H])C([H])=C1C([H])([H])[H])C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NC2=C(C([H])=NN12)C1=C([H])C([H])=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(N([H])C(=O)OC([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=S)N1C([H])([H])C([H])([H])C([H])(N(C([H])([H])[H])C([H])([H])[C@@]2([H])OC([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C(OC([H])([H])[H])C([H])=C1[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])=C(N=C1C1=C([H])C([H])=C([H])N=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C([H])([H])N(C(=O)OC([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])[H])C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]C1=C(N=C2C([H])=C([H])C(=NN12)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C1=C(C(=NN1C1=C(Cl)C([H])=C(Cl)C([H])=C1Cl)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])C1=NN([H])N=N1 [H]C1=NC(=C(C(=O)N2C([H])([H])[C@@]3([H])C([H])([H])N(C([H])([H])C([H])([H])C4(C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])N(C(=O)[C@@]5([H])C([H])([H])OC([H])([H])C5([H])[H])C4([H])[H])C([H])([H])[C@@]3([H])C2([H])[H])C(=N1)C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@]13C([H])([H])C([H])([H])N(C([H])([H])C4=C([H])C([H])=C([H])O4)[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)C([H])([H])[H])C1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])SC(=N1)N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C2=C([H])C3=C(C([H])=C2C(=C([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C1=C(C([H])=C(Cl)C([H])=C1[H])C3([H])[H] [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC([H])([H])[C@@]([H])(C#N)N([H])C(=O)[C@@]([H])(N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C(C([H])=NN1C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])C([H])([H])N2C2=NC3=C(S2)C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C3([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C(ON=C1C1=C(Cl)C([H])=C([H])C([H])=C1Cl)C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] COC1=CC(=CC=C1OCCN1CCCC1)N1CC2=CC=C(SC3=CC=C(F)C=C3)N=C2C1=O [H]OC(=O)C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H] [H]O[C@]([H])(C1=C([H])C([H])=C([H])N=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])S(=O)(=O)C2=C([H])C([H])=C(C([H])=C2[H])N2C(=O)N(C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=N1)C([H])([H])N1C(=O)N(C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])OC4=C([H])C([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=C([H])C2=NC(N(C3([H])C([H])([H])C3([H])[H])C3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C3C([H])=C([H])C(F)=C([H])C3=C2C1=O [H]N(C(=O)N([H])[C@@]1([H])C(=O)N(C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(N([H])C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1[H])C1=NN=C([H])S1 CN1C=C(C(=O)NC2=CC(Cl)=C(CC(=O)N3C[C@@H](O)C[C@H]3CO[C@H]3CC[C@@H](CC3)C(O)=O)C=C2Cl)C2=C1C=CC=C2 [H]C1=C([H])C(=C([H])C([H])=C1F)C(=O)N(C1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(C([H])([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])[C@]([H])(F)C1([H])[H])[N+]([H])([H])[H])C([H])([H])[H] [H]OC1=C2C([H])=C(C3=C([H])N=C([H])O3)C(OC([H])([H])[H])=C([H])C2=NC(=C1[H])C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@]1([H])N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])[C@@]([H])(C(=O)N1C([H])([H])C([H])([H])C(C([H])([H])N2C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])S2(=O)=O)(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C(N([H])C2=NC3=C(N=C([H])N3[H])C(=N2)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C#N)C1=C(Cl)C([H])=C([H])N=C1N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C(=O)OC([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])C(Cl)=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=NOC2=C1C([H])([H])C([H])([H])C1=C2C([H])=C([H])C(OC([H])([H])[H])=C1[H])[C@]([H])(C([H])([H])[H])C([H])([H])OC([H])([H])[H] [H]N(C1=NC(=NC2=C1C([H])=C(N2C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])N1C([H])=NC2=C1C([H])=NC([H])=C2[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C(=C2N=C(N=NC2=C1[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])N=C(S1)N([H])C(=O)C1=C([H])C2=C(N(C1=O)C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N(C([H])([H])C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])N(N=N2)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(OP(=O)(O[H])O[H])C([H])([H])[H])C([H])([H])O[H])C([H])([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])SC([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([C@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=NN=C(S3)C(F)(F)F)C([H])([H])C2([H])[H])[C@@]([H])(C2=C([H])SC([H])=C2[H])C1([H])[H])C1(C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N=C(N([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]O[C@@]([H])(C([H])([H])OC1=C2C([H])=C([H])N([H])C2=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C4=C([H])C([H])=C([H])C(C2=O)=C34)C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(=NC(=N1)C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])OC2([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])C1(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(N=C2N1C1=C([H])C([H])=C(Cl)C([H])=C1C(=N[C@@]2([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1F)C([H])([H])[H] [H]OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C(Cl)N=C3N([H])C([H])([H])C2=C([H])C(I)=C([H])C([H])=C2[H])[C@]([H])(O[H])[C@@]1(O[H])C([H])([H])[H] [H]N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N/C([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)\N([H])C([H])([H])C1=C([H])C([H])=C(I)C([H])=C1[H] [H]N(C(=O)C#CC([H])([H])OC([H])([H])OC([H])([H])[H])C1=C([H])C2=C(N=C([H])N=C2N([H])C2=C([H])C(Br)=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])N1N=NN=C1C(F)(F)F)[C@@]1([H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C([H])([H])O[P@](=O)(O[H])O[P@](=O)(O[H])OC([H])([H])[C@@]2([H])O[C@@]([H])(C3=NC(=C([H])S3)C(=O)N([H])[H])[C@]([H])(O[H])[C@]2([H])O[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C([H])=C([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C(N=C2N([H])[H])C#CN([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H] [H]OC1=C([H])C([H])=C(OC([H])([H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C3[H])C([H])=C2[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C(=C1[H])C([H])([H])[H])C([H])([H])OC([H])([H])[C@@]1([H])C([H])([H])[C@@]23C([H])([H])C([H])([H])[C@]1(OC([H])([H])[H])[C@]1([H])OC4=C(OC([H])([H])[H])C([H])=C([H])C5=C4[C@]21C([H])([H])C([H])([H])N(C([H])([H])[H])[C@]3([H])C5([H])[H] [H]N(C1=NC([H])=C(SC2=C([H])C(C(=O)N3C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C3([H])[H])=C(C([H])=C2[H])C([H])([H])[H])S1)C1=NC(Br)=C([H])C([H])=C1[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(OC2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(\N=C(/[H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1=NC(=NC(=N1)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C(Cl)=C([H])C([H])=C1S2 [H]N(C(=O)N([H])[C@@]1([H])N=C(N2C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C2N(C1=O)C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C([H])([H])[H] [H]C1=C(SC2=C1C(=NC([H])([H])C1=NN=C(N21)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C([H])([H])C([H])([H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])[H] [H]O[C@]([H])(C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])[C@@]([H])(N([H])C(=O)C1=C([H])C2=C3N(C([H])=C(C3=C1[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])S(=O)(=O)N2C([H])([H])C(F)(F)F)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] Cc1ccccc1CNC(=O)c1cc(c[nH]1)-c1ccnc(N)n1 [H]N([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])OC1=C2N=C(C([H])=C([H])C2=C([H])C(F)=C1[H])C1=NN=C2C([H])=C([H])C([H])=C([H])N12 [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C(OC([H])([H])C(=O)C2=C([H])C([H])=C(Br)C([H])=C2[H])=NN1C([H])([H])[H] [H]N1C(=O)[C@]2(C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2(C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])[C@]([H])(C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC(=O)C1=NC(=C([H])C([H])=C1[H])C1=C([H])N=C(O1)C(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])SC([H])([H])C1([H])[H] [H]OC(=O)C1=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N(C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C([H])C(=C1[H])C(=O)C([H])([H])[H] [H]N(C(=O)C1=C([H])C2=C([H])C(N([H])C(=O)C([H])([H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(OC([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])C2=C(N([H])C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C([H])([H])Cl)C(=O)C([H])=C(N([H])C(=O)\C(=C(/[H])\C(\[H])=C([H])/[C@]([H])(OC([H])([H])[H])[C@@]([H])(OC(=O)N([H])[H])\C(=C([H])\[C@]1([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C2=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C(=C([H])N(C1=O)C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])[C@@]2([H])C([H])([H])[H])C([H])=C1[H] [H]O[C@]1([H])C([H])([H])C([H])([H])[C@@]2(C([H])([H])[H])[C@@]([H])(C1([H])[H])C([H])([H])[C@]([H])(O[H])[C@@]1([H])[C@]3([H])C([H])([H])C([H])([H])[C@]([H])([C@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])C(=O)N4C([H])([H])C([H])([H])N(C([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])C4([H])[H])[C@@]3(C([H])([H])[H])C([H])([H])C([H])([H])[C@]21[H] CN1C=CC(=N1)C1=CC2=C(SC3=C(CC2N2CCN(C)CC2)C=CC=C3)C=C1 [H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(SC(=C2[H])C(N([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C2=C(N(C3=C([H])C([H])=C([H])C([H])=C23)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])N=C1[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])N2C(SC3=C2C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C3[H])=N1)C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C(Cl)C([H])=C2C2=C1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C2([H])[H] [H]C1=C([H])C([H])=C(O\N=C(\C2=C([H])C([H])=C(Br)C([H])=C2[H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2(C([H])([H])[H])C([H])([H])C([H])([H])N(C(=O)C3=C(C([H])=C([H])C([H])=C3C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]N(C1=NC(=NC2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C(=N1)C([H])([H])[H])C1=C([H])C([H])=NC([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])C1=NN=C(S1)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C([H])=C(C([H])=C([H])C2=N1)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]ON([H])C(=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C1=C(C2=C(OC([H])([H])O2)C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N2C([H])=C([H])C([H])=C(C2=N1)C(F)(F)F)C1=C([H])C(OC2=C([H])C(=C([H])C([H])=C2[H])S(=O)(=O)C([H])([H])[H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(N([H])C2=NC([H])=C([H])C(=N2)C2=C([H])C([H])=C([H])N=C2[H])=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)O[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])SSC1(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C1=C([H])C2=C(C([H])=C1[H])N1C([H])=C([H])C([H])=C1C(=O)N2[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C(N=C2SC([H])=C([H])N12)C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C1C(=C2[H])C([H])([H])C([H])([H])[C@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C([H])C(\C([H])=C2/SC(=NC2=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])=C1[H] CCOC(=O)\C=C\C1=CC=C(O)C=C1 [H]OC([H])([H])[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C(S1)C1=NC(=NC([H])=C1[H])N([H])C([H])([H])[H])C([H])([H])C1=C(Cl)C([H])=C(Cl)C([H])=C1[H]