[H]N([H])C1=NC2=C([H])C([H])=C([H])C(Cl)=C2[C@]([H])(N1[H])C([H])([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(=O)N1C([H])([H])C([H])([H])[C@]2([H])N(C(=O)C3([H])C([H])([H])C3([H])[H])C(=O)[C@@]([H])(C([H])([H])[H])[C@@]12[H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])C1=C([H])C([H])=C(C([H])=N1)N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C([H])C([H])=C1[H])S(=O)(=O)N([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C([H])C(O[H])=C1[H])C([H])([H])[C@@](O[H])(C(=O)N([H])C1=C([H])C2=C(C([H])=C1[H])C(=O)OC2([H])[H])C([H])([H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]SC([H])([H])C1=C([H])C([H])=C(O1)C1=C([H])C([H])=C([H])N=C1[H] [H]OC(=O)[C@@]1([H])[C@]2([H])[S@@](=O)C([H])([H])[C@@](N([H])[H])(C(=O)O[H])[C@]12[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C(OC([H])([H])C([H])([H])[H])=C2[H])C([H])=C1[H] [H]N(C(=O)[C@@]([H])(N([H])[C@@]([H])(C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(N=C1[H])S(=O)(=O)C([H])([H])[H])C(F)(F)F)C([H])([H])C(F)(C([H])([H])[H])C([H])([H])[H])C1(C#N)C([H])([H])C1([H])[H] [H]N(C(=O)C(=O)N([H])C([H])([H])C1=C([H])C([H])=C(O1)C(\[H])=C1\N([H])C(=C(C(=O)OC([H])([H])C([H])([H])[H])C1=O)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C(=C2N=C(N(C2=C1[H])C([H])([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N1C(=O)C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C(C([H])=C3[H])C(=N[H])N([H])[H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])OC([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]N(C(=O)[C@]([H])(C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C2(C([H])=C([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)C(F)(F)F [H]OC(=O)C1=C2C(=NC3=C([H])C([H])=C(F)C([H])=C13)C1=C([H])C3=C(C(=O)N1C2([H])[H])C([H])([H])OC(=O)[C@]3(O[H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(C2=C([H])N=C(N=C2N(C1=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])N([H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C(=C1[H])C(F)(F)F [H]N(C(=O)C1(N([H])C(=O)C(F)(F)F)C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1C1=NN(N=N1)C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@@]([H])(O[C@]2([H])[C@]([H])(C(=O)O[C@]([H])(C([H])([H])C([H])([H])[H])[C@](O[H])(C([H])([H])[H])[C@]([H])(O[H])[C@]([H])(C(=O)[C@]([H])(C([H])([H])[H])C([H])([H])[C@](OC([H])([H])[H])(C([H])([H])[H])[C@]([H])(O[C@]3([H])O[C@]([H])(C([H])([H])[H])C([H])([H])[C@]4([H])N(\C(O[C@@]34[H])=N\C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])[C@@]2([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[C@]1(OC([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C(I)=C2[H])C([H])([H])C1([H])[H] [H]N(\N=C(\C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])[H])C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C2N([H])C(=C(C2=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C([H])([H])[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C3(OC([H])([H])C([H])([H])O3)C([H])([H])C2([H])[H])C2=NN(C(=O)N12)C([H])([H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C(=O)N([H])[C@]12C([H])([H])[C@@]3([H])C([H])([H])[C@]([H])(C([H])([H])[C@]([H])(C3([H])[H])C1([H])[H])C2([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])[C@@]1(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])=C([H])[H])[C@]([H])(C2([H])[H])[C@]1([H])C([H])([H])[H] [H]N1N=C(C(=C1C([H])([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3N=C(N([H])C3=C([H])C([H])=C2[H])C2=C([H])C([H])=C(C([H])=C2[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N(C1=C(N=C2C([H])=C([H])C([H])=C([H])C2=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N([H])C([H])([H])[H] [H]C1=C([H])C(C2=C3N=C(N=C(N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])N3N=C2C([H])([H])[H])C([H])([H])[H])=C(Cl)C([H])=C1Cl [H]N(C(=O)N([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)N([H])C2=C([H])C3=C(OC([H])=N3)C([H])=C2[H])C1=O [H]C1=C([H])C2=C(C([H])=C1[H])C(=C([H])C([H])=C2[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(=O)N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C#N)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]C1=C([H])C(Cl)=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])N2C3=C(C(OC([H])([H])C([H])([H])[H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])C2=O)C([H])([H])C1([H])[H] [H]OC(=O)[C@@]1([H])[C@@]([H])(N(C([H])([H])C(=O)N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[C@]1([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)C1=C(Cl)C([H])=C(F)C(=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] OCC1=C(OCC(O)CNC2CCN(CC2)C2=NC=NC3=C2C(=CS3)C2=CC=CC=C2)C=CC(O)=C1 [H]\C(C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])=C1/C(=NC([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])N=C1[H] [H]N1C([H])=C([H])C2=C(C([H])=C([H])C([H])=C12)C1=NC([H])=C(N=C1[H])N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]N(C1=C([H])C([H])=C([H])C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])[H] [H]C1=C([H])C(=C2C(=O)N(C([H])([H])OC3=C([H])C([H])=C(C([H])=C3[H])S(=O)(=O)N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])S(=O)(=O)C2=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])N(C(=N2)C([H])([H])N1C([H])([H])[C@@]2([H])[C@]([H])(C([H])([H])OC3=C([H])C([H])=C(Cl)C([H])=C3[H])[C@@]2([H])C1([H])[H])C([H])([H])[H] [H]N(C1=C([H])N(C(=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])[H])C1=NC([H])=C2C([H])=NN(C2=N1)[C@@]1([H])C([H])([H])[C@]2([H])C([H])([H])[C@]2([H])C1([H])[H] [H]C1=C2C([H])([H])C([H])([H])[C@@]3([H])[C@]4([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)C([H])([H])[H])[C@@]4(C([H])([H])[H])C([H])([H])C([H])([H])[C@]3([H])[C@@]2(C([H])([H])[H])C([H])([H])C([H])([H])C1=O [H]C1=C(C(=O)C2([H])C(C([H])([H])[H])(C([H])([H])[H])C2(C([H])([H])[H])C([H])([H])[H])C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2N1C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1N=C(N(C1=S)C([H])([H])[H])C1=C([H])C2=C(O1)C(OC([H])([H])[H])=C([H])C([H])=C2[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC2=C([H])C([H])=C(C([H])=C2N([H])[H])C(=N[H])N([H])[H])C(N([H])[H])=C1[H] [H]O[C@@]1(C2=C([H])C([H])=C(C([H])=N2)C2=C([H])N=C([H])N=C2[H])C([H])([H])C([H])([H])[C@]([H])(N([H])[C@]2([H])C([H])([H])N(C(=O)C([H])([H])N([H])C(=O)C3=C([H])C(=C([H])C([H])=C3[H])C(F)(F)F)C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])C1=C(C([H])=C([H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])N(N=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON(C(=O)N([H])[H])[C@@]1([H])C2=C(OC1([H])[H])C([H])=C([H])C(OC1=C([H])C([H])=C([H])C([H])=C1[H])=C2[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C([H])N(N=C12)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=C1C(=O)OC([H])([H])C1=C([H])C([H])=C([H])O1)C([H])([H])[H] [H]N([H])C1=NC2=C(S1)C([H])([H])[C@@]([H])(N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C3=C(C([H])=C([H])C([H])=C3[H])N3N=C([H])C([H])=C3[H])C([H])([H])C1([H])[H])C([H])([H])C2([H])[H] [H]C([H])=C1[C@]([H])(C(=O)N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C([H])=C2C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N2C(=O)N(N=C2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C2C(F)(F)F)[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C2([H])[H] [H]N1N=C(C2=C([H])C([H])=C(OC([H])([H])[H])N3N=C(C([H])=C23)C([H])(F)F)C(C1=O)(C([H])([H])[H])C([H])([H])[H] [H]N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])[C@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C(=O)C1=NN(C(=C1C([H])([H])[H])C1=C([H])C([H])=C(Br)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])S(=O)(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=C([H])N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)OC([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])[C@]1([H])N1[C@@]2([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H] [H]N1N=C(C2=C(N=NS2)C([H])([H])[H])\C(=C(/[H])C2=C([H])N(C3=C2C(OC([H])([H])C2=C(F)C([H])=C([H])C([H])=C2Cl)=C([H])C([H])=C3[H])C([H])([H])[H])C1=O [H]N([H])C1=N[C@@](C(=O)N1C([H])([H])[H])(C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])N=C([H])C([H])=C1[H])C1=C([H])C(F)=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(OC([H])(C([H])([H])[H])C([H])([H])[H])=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@]1(OC([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])N=C1[H] [H]C1=C([H])C(=C([H])C([H])=C1F)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])[C@](OC([H])([H])[H])(OC1=O)C([H])([H])[H] CCN1CCN(CC1)C1=CC=CC(=N1)C1=CC=C(C=C1F)C#C[C@]1(CN2CC3=C(C2=O)C(F)=C(OC)C=C3)CC(=O)NC1=O [H]C1=C([H])C(OC(F)(F)F)=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]O[C@]1([H])C([H])([H])C([H])([H])N2C(=O)N(C(=O)[C@]12[H])C1=C(C(=C(C#N)C([H])=C1[H])C(F)(F)F)C([H])([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C(=O)N([H])C2=C([H])C([H])=C([H])C(=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C(=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(N([H])C2=NC([H])=NC3=C([H])C(OC([H])([H])C([H])([H])C([H])([H])N4C([H])([H])C([H])([H])OC([H])([H])C4([H])[H])=C(OC([H])([H])[H])C([H])=C23)C([H])=C1[H] [H]N([H])C(=[N+]([H])[H])C1=C([H])C([H])=C([H])C(N([H])C(=O)C([H])([H])N([H])S(=O)(=O)C2=C([H])C([H])=C([H])C3=C([H])C([H])=C([H])C([H])=C23)=C1[H] O=C(NC1=NOC2=C1C=CC=C2)N1CCN(CC1)C1=NC(=NO1)C1=CC=CC=C1 [H]N([H])C(=O)O[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])C1([H])[H] [H]N=C(N([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])C([H])([H])N([H])C(=O)C2([H])C([H])([H])C([H])([H])N(C3=C([H])C([H])=NC([H])=C3[H])C([H])([H])C2([H])[H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=NN=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[S@](=O)C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(N([H])C1=C2C([H])=C([H])C([H])=C([H])C2=NC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)N([H])[C@@]2([H])C([H])([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])C([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@@]([H])(O[H])C([H])=C([H])[C@@]4([H])[C@]5([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C2=C(N1[H])C(=O)N(C(=O)N2C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C#N)C([H])=C1[H] [H]OC1=C([H])C([H])=C(N([H])C(=O)C2=C([H])C([H])=C(N([H])C(=O)C3=C([H])C([H])=C([H])C([H])=C3O[H])C([H])=C2[H])C([H])=C1O[H] [H]N(\N=C(/[H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=NC(=C([H])S1)C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N([H])C(=NC2=O)N([H])[H] [H]OP(=O)(O[H])C(F)(F)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])(OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)P(=O)(O[H])O[H] [H]C1=C(C([H])=C2SC(=NC2=N1)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C1=C([H])N=C(C([H])=C1[H])C([H])([H])[H] [H]OC(=O)C1=C(N([H])C(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C2=NC(=NO2)C2=NC([H])=C(O[H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])C2=C([H])C(=C([H])C(=C2O[C@@]1([H])C(F)(F)F)C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C(F)C(Cl)=C([H])C(=C1[H])C1(C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=C(N=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=NC([H])=N2)C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])[C@]([H])(C([H])([H])[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N1C([H])=C([H])C([H])=C(N([H])C(=O)C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C1=O)C([H])([H])C([H])([H])[H])C(=O)C([H])([H])N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C(O1)C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])[C@]([H])(N([H])[H])C([H])([H])C2=C(F)C([H])=C(F)C(F)=C2[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N([H])S(=O)(=O)C1=C(OC2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])=C([H])C(=C1[H])[N+]([O-])=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C1=C([H])N=C(C([H])=C1[H])N(C1=C([H])C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C(C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N=C(N([H])[H])N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1[H])C([H])([H])C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]N(C(=O)N1C([H])([H])[C@@]([H])(N(C2=C([H])C(=C(C#N)C([H])=C2[H])C(F)(F)F)C([H])([H])[C@@]1([H])C([H])([H])[H])C([H])([H])[H])C1=C(OC([H])([H])[H])N=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])S(=O)(=O)C1=C(C([H])=C2OC([H])([H])OC2=C1[H])C([H])([H])C(=O)N(C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([C@@]([H])(C([H])([H])[H])[C@]([H])(C1=C([H])C([H])=C([H])C(C#N)=C1[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC2=NN(C([H])=C2C2=NC(=NN12)C1=C([H])C([H])=C([H])O1)C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] COC1=CC(\C=C2/CCC\C(=C/C3=CC(O)=C(OC)C=C3)C2=O)=CC(OC)=C1 [H]OC(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(C([H])=C([H])C(N([H])S(=O)(=O)C3=C([H])C([H])=C(C([H])=C3[H])C(F)(F)F)=C2[H])N(C2=C([H])C3=C(C([H])=C12)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C3(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] O=C(NCCC1CC1)C1=NN=C(C=C1)N1CCN(CC1)C(=O)C1=CC=CC=C1C#N [H]N(C(=O)C1=C([H])C([H])=C(N([H])C2=C([H])C([H])=NC([H])=N2)C([H])=C1[H])C1=NC(=C(S1)C([H])([H])[H])C1=C([H])C([H])=C(F)C(=C1[H])C(F)(F)F [H]OC(=O)C([H])([H])N1C(=O)C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C3([H])C([H])([H])C([H])([H])N([H])C([H])([H])C3([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]12C([H])([H])C([H])([H])[C@@]3(C([H])([H])[H])[C@@]4([H])C(=C([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]1([H])[C@]([H])(O[H])C([H])([H])[C@@]2([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C(C([H])([H])[C@]4([H])O[H])[C@](C([H])([H])[H])(C([H])([H])O[H])[C@@]([H])(O[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N(C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]OC1=C(C(=O)OC([H])([H])C([H])([H])O[C@@]([H])(C([H])([H])C([H])([H])[H])[C@@]([H])(C(=O)OC([H])([H])[C@@]2([H])OC(=O)C(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=C2O[H])C([H])([H])[H])C(=O)O[C@]1([H])C([H])([H])O[H] [H]N1C(=O)C(=C([H])C(C(=O)OC([H])([H])C([H])([H])[H])=C1C([H])([H])OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])SC(=N1)C([H])([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)[C@@]1([H])N([H])C([H])([H])C([H])([H])C1([H])[H])C1=C(OC([H])([H])C([H])([H])OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H] [H]OC(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C([H])([H])P(=O)(O[H])O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])[C@@]1([H])N(C2=C(C([H])=C(Cl)C([H])=C2[H])C(=NC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C(N2C(=C1[H])[C@]([H])(SC1=C([H])C([H])=C([H])C([H])=C21)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]C1=C2C(=C([H])C(=C1[H])C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])O[C@@]2(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C([H])([H])C1=C(N([H])C([H])=C1C([H])([H])[H])C(\[H])=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C(=C12)C([H])([H])[H] [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C2SC(=C(C2=C1[H])C([H])([H])[H])C1=NC(=NC([H])=C1[H])N([H])[H] [H]ON([H])C(=O)[C@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C1=C(N(N=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(F)C([H])=C1Cl [H]N([H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])N1N=C(C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])N(C(=O)C1=C([H])C2=C(N=C(O2)N([H])C([H])([H])C#C[H])C([H])=C1[H])C([H])([H])C#C[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(N([H])C(=O)C([H])([H])SC1=NN=C(N1N([H])C(=O)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C1=C(SC2=C1C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N([H])C(=O)C([H])([H])[H])C(=O)C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC([H])([H])C1=NC2=C([H])C([H])=C(C([H])=C2C([H])=C1[H])N1C([H])=NC2=C(SC(=C2[H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C1=O [H]OC(=O)C([H])([H])N(C(=O)C(=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)OC1=C([H])C([H])=C(C([H])=C1[H])C(=N[H])N([H])[H])\C([H])([H])[H])C([H])([H])C([H])=C([H])[H] [H]C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])(C([H])([H])C3=C([H])C([H])=C(Br)C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC([H])([H])[C@]1([H])N([H])C([H])([H])C2=C([H])C(=C([H])C([H])=C2C1([H])[H])S(=O)(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C(=O)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]C1=C([H])C([H])=C2C3=NN=C(C([H])=C3C(=O)C2=C1[H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]OC(=O)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC([H])([H])C3=C([H])C([H])=C(C([H])=N3)C([H])([H])[H])=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])N=C1[H] [H]OC([H])([H])C([H])([H])OC(=O)C1=C(N([H])C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])=C(S1)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])[C@](N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])(C(=O)O[C@@]1([H])C([H])([H])[N@+]2(C([H])([H])C([H])([H])C3=C([H])[C@]4([H])C([H])([H])C([H])([H])O[C@]4([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])[H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])(O[C@@]1([H])C([H])([H])[C@@]2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N([H])C([H])([H])[C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(C([H])([H])N([H])C2=NC(=NC([H])=C2[N+]([O-])=O)N([H])[C@@]([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N1C(=O)N(C2=C(C1=O)C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C2([H])[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1F [H]OC(=O)C(=O)N([H])[C@@]([H])(C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C(=O)O[H] [H]C1=C(N=C(N1C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C3=C([H])C([H])=C([H])C([H])=C3C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C2=NN=C(C3=C([H])C([H])=C([H])O3)C(=O)N2C2=C([H])C([H])=C([H])C([H])=C12 [H]OC(=O)[C@]([H])(N([H])C(=O)[C@]([H])(C([H])([H])S[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])SC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H] [H]N(C1=C([H])C(Cl)=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C([H])=C1[H])C1=NC([H])=NC2=NN3C([H])=C([H])C([H])=C([H])C3=C12 [H]C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])N([C@]([H])(C([H])([H])[H])C1([H])[H])S(=O)(=O)C([H])([H])[C@@]12C(=O)C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(OC(=O)N(C([H])([H])[H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])[C@]3(C4=C(C([H])=C([H])C([H])=C4[H])[S@](=O)C3([H])[H])C([H])([H])C2([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C(=C([H])C(=C1[H])[N+]([O-])=O)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])OC1=C([H])C([H])=C2C(=O)N(SC2=C1[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(=O)N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C([H])C(=N4)C([H])([H])[H])C([H])([H])C3([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N(C(=O)OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])[C@]2([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(Cl)C([H])=NC([H])=C1Cl)C([H])([H])C([H])([H])[C@@]([H])(N1C([H])([H])C([H])([H])C([H])(N(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C2=C([H])C([H])=C([H])C(C#N)=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@]1(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]OC(=O)C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C1=NC2=C([H])C(Cl)=C([H])C([H])=C2N1C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC1=C([H])C([H])=C2C(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])[C@]([H])(N([H])[H])[C@]([H])(C([H])([H])C([H])([H])[H])C2([H])[H] [H]OC(=O)C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])OC2=C1C(=NC(=N2)N([H])[H])N([H])[H])C(=O)O[H] [H]O[C@@]1([H])C([H])([H])N([C@]([H])(C(=O)N(C([H])([H])[H])C([H])([H])[H])C1([H])[H])[C@@]1(C(=O)N(C2=C([H])C([H])=C(Cl)C([H])=C12)S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H])C1=C(OC([H])([H])[H])C([H])=C([H])N=C1[H] [H]C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(Cl)=C(Cl)C(=C1[H])C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C1=C(N([H])C(=O)C2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(=O)C3=C(C([H])=C([H])C(=C3[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)C2=C1[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@@]1([H])C([H])([H])C([H])([H])[C@]3(C([H])([H])[H])[C@@]([H])(N([H])S(=O)(=O)C([H])([H])C4=C([H])C([H])=C(C([H])=C4[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]3([H])[C@]1([H])C([H])([H])C2([H])[H] [H]N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=NC(C2=NC(=C([H])S2)C([H])([H])[H])=C(N1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])C1=NC2=C(C([H])=NN2C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(=N1)C1=C([H])C([H])=C([H])O1 [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=NN=C2SC([H])([H])C(=NN12)C1=C(OC([H])([H])[H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]N([C@@]1([H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])N(C3=C(OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=NC([H])=C1[H])C1=NC(=C([H])S1)C([H])([H])N(C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C1=C(Br)C2=C([H])C(O[H])=C([H])C([H])=C2C1=O [H]OC(=O)C1=C([H])C([H])=C(O[H])C(\C([H])=N\N([H])C(=S)N([H])C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1[H] [H]C1=C([H])C([H])=C([H])C(=N1)N(C(=O)C1=C([H])C(=C([18F])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])[C@@]1([H])OC2=C(OC1([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C2=C([H])C([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(C(=O)C2=C(N([H])S(=O)(=O)C3=C(Cl)C([H])=C(Cl)C([H])=C3[H])C([H])=C([H])C([H])=C2[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C([H])([H])N(C(=O)[C@@]([H])(OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H] [H]N([H])C1=C([H])N=C(N(C1=O)C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)C1=NC2=C(O1)C([H])=C([H])C(=C2[H])C(=O)OC([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]OC1=C([H])C(=C([H])C([H])=C1C(=O)N1C([H])([H])C([H])([H])C(=C([H])C(=O)N([H])[C@@]2([H])C([H])([H])N(C([H])([H])C3=C([H])C([H])=C4C([H])=C(F)C([H])=C([H])C4=C3[H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C(F)C(=C([H])C([H])=C1[H])C1=C([H])N(C(=O)N(C1=O)C([H])([H])[C@]([H])(N([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C(F)C([H])=C([H])C([H])=C1C(F)(F)F NC1=C2CCCCC2=NC2=CC=C(O)C=C12 [H]N(C(=O)C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C(=C([H])C([H])=C1[H])C([H])([H])[H])C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(C([H])([H])N([H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C2([H])[H] [H]OC(=O)C1=C(O[H])C([H])=C2N=C([H])N(C2=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=NC2=C(N=C([H])N2C([H])([H])C2=[N+]([O-])C([H])=C(C(OC([H])([H])[H])=C2C([H])([H])[H])C([H])([H])[H])C(Cl)=N1 OC(=O)[C@H]1CC[C@@H](CC1)OC[C@@H]1C[C@H](F)CN1C(=O)CC1=CC=C(NC(=O)C2=CNC3=C2C=CC=C3)C(Cl)=C1 [H]OC1=C(O[H])C2=C(OC3=C([H])C(OC([H])([H])[H])=C([H])C(O[H])=C3C2=O)C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1(O[C@]([H])(C([H])([H])[H])C([H])([H])C1=O)C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1OC([H])([H])[H] [H]OC1=C([H])C2=C(C([H])=C1[H])[C@]([H])(N(C([H])([H])[H])C([H])([H])C2([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C(OC3=C([H])C(=C([H])C([H])=C3[H])[C@]([H])(N3C(=O)[C@@]1([H])C([H])([H])C3([H])[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H])=C(C#N)C([H])=C2[H] [H]C1=NC(=O)N(C([H])=C1C([H])([H])C1=C([H])N(C(SC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=NC1=O)C([H])([H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]ON([H])C(=O)[C@@]1([H])N(C2=C([H])C([H])=C(OC([H])([H])C3=C([H])C(=NC4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])[H])C([H])=C2[H])S(=O)(=O)C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])([H])C([H])([H])C([H])(C([H])([H])C1([H])[H])[C@]([H])(OC1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC1=C2O[C@@]3([H])[C@]([H])(N([H])C(=O)C4=C([H])C([H])=C(C([H])=C4[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@@]4(O[H])[C@]5([H])N(C([H])([H])C6([H])C([H])([H])C6([H])[H])C([H])([H])C([H])([H])[C@]34C2=C(C([H])=C1[H])C5([H])[H] [H]N(C1=C2C(=NC(=N1)C([H])([H])[H])N(N=C2C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C2=C(N=C(O2)N2C([H])([H])C([H])([H])[N@]3C([H])([H])C([H])([H])[C@]2([H])C([H])([H])C3([H])[H])C([H])=N1 [H]N1N=C([H])C2=C(C([H])=C([H])C(F)=C12)C1=C2N=C([H])C([H])=C(N2N=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C(F)C([H])=C(C([H])=C1F)N1C([H])([H])[C@@]2([H])N(C([H])([H])[H])C([H])([H])[C@]1([H])C2([H])[H] [H]OC1=C([H])C([H])=C2C3=NO[C@@]([H])(C([H])([H])N4C([H])([H])C([H])([H])N(C([H])([H])C(=C(/[H])C5=C([H])C([H])=C([H])C([H])=C5[H])\C([H])([H])[H])C([H])([H])C4([H])[H])[C@]3([H])C([H])([H])OC2=C1[H] [H][C@@]12C[C@H](OC(=O)C3=CC=C(O)C=C3)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@]1(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N(C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)C1=NC([H])=C([H])C([H])=C1[H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)OC([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@]([H])(C(=O)C(=O)N([H])[C@@]([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C(N([H])S(=O)(=O)C([H])([H])[H])C([H])=C(C([H])=C1[H])[C@@]([H])(O[H])C([H])([H])N([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C1=NC([H])=C([H])C(=N1)C1=C([H])C(=NC([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C(OC([H])([H])[H])=C1[H] [H]OC1=C2C(N([H])C([H])=C2C2=C(N=C(Cl)N=C2[H])N([H])[H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C1=C(C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C(=O)N([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])[H])C([H])([H])C2=C([H])C([H])=C(O[H])C([H])=C2[H])C(SSC1([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C2N=C(SC2=C([H])C(=N1)C1=C([H])C([H])=C(C#N)C([H])=C1[H])N1C([H])([H])C([H])([H])C([H])(N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=N1)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([C@]1([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N2C([H])([H])C([H])([H])N(C3=NC4=C(O3)C([H])=C([H])C([H])=C4[H])C([H])([H])C2([H])[H])[C@@]([H])(C2=C([H])SC([H])=C2[H])C1([H])[H])C(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C(Cl)C([H])=C1Cl)C(=O)N([H])C1=C([H])C([H])=C(OC2=NC3=C(S2)C([H])=C([H])C([H])=C3[H])C([H])=C1[H] [H]N1C(=O)C([H])=C(C2=C1C([H])=C([H])C1=C2OC([H])([H])C2=C1C([H])=C([H])C([H])=C2[H])C(F)(F)F [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(C2=C(Cl)C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]11C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])C1([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=NN([H])N=N1 [H]N(C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1N=C(C([H])=C1C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=C([H])C([H])=C(OC(F)(F)F)C([H])=C1[H])C1=NN([H])N=N1 [H]OC1=C(O[H])C([H])=C(C([H])=C1[H])[C@@]1([H])C2=C(SC([H])=C2[H])C([H])([H])N([H])C1([H])[H] [H]OC1=C(Cl)C([H])=C2C(=C1[H])[C@]([H])(C([H])([H])C#C[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C(OC2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])N1C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[S@@](=O)C([H])([H])[C@]1([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H] [H]OC1=C([H])C(O[H])=C2C(=O)C(OC(=O)[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])=C(OC2=C1[H])C1=C([H])C(O[H])=C(O[H])C([H])=C1[H] [H]N1C2=C(C([H])=C1C1=C([H])C(=C3N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[C@@]([H])(C3=C1Cl)C([H])([H])[H])C([H])([H])[H])C([H])=C([H])C([H])=C2[H] [H]OC(=O)C([H])([H])[C@]1([H])N([H])C2=C([H])C([H])=C(C([H])=C2C([H])([H])N(C1=O)C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])C1=NC2=C(N1[H])C([H])=C(F)C(F)=C2[H] [H]N1C(=NN=C1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=NC3=NC(=NC([H])=C3C([H])=C2C2=C([H])C([H])=C([H])C([H])=C2[H])N2C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])C2([H])C([H])([H])N(C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H])C1=NC([H])=C([H])C([H])=C1[H] [H]N1N=C(N(\N=C(/[H])C2=C([H])C([H])=NC([H])=C2[H])C1=S)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C2C([H])=C([H])N([H])C2=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C#N [H]ON([H])C(=O)C1(C([H])([H])S(=O)(=O)C2=C([H])C([H])=C(OC([H])([H])C#CC([H])([H])[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])[H])C1=C([H])C([H])=C(C(N([H])C2=NC([H])=C([H])C(=N2)N2C([H])=NC3=C2C([H])=C([H])C([H])=C3[H])=C1[H])C([H])([H])[H] [H]ON(C(=O)N([H])[H])[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)[C@]2(N3C([H])([H])SC([H])([H])[C@]3([H])[C@@]([H])(C3=C([H])C([H])=NC([H])=C3[H])[C@@]22C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C2=C1C([H])=C([H])C(Cl)=C2[H] [H]OC([H])([H])C1=C(Cl)N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1C1=NN([H])N=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C(=O)C1=NN(C(=C1[H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C(F)(F)F)C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C2=C1C(=O)[C@@]([H])(C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C2([H])[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C1=NC([H])=NC2=C1SC(C#C[C@@]1([H])N([H])C([H])([H])[C@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])=C2[H])C1=C([H])C([H])=C(OC([H])([H])C2=C([H])C([H])=C([H])C(F)=C2[H])C(Cl)=C1[H] CN1N=C(C2CCCCC2)C2=C3C=CNC3=NC=C12 [H]N([H])C1=C([H])C(=NC([H])=N1)N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])N([H])C1=C([H])C(N([H])C(=O)C2=C([H])C(=C([H])C(OC3([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C3([H])[H])=C2[H])C(F)(F)F)=C([H])C([H])=C1C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=C([H])C2=C1C([H])=C([H])C(OC1=NC([H])=NN3C([H])=C(C([H])=C13)C(=O)OC([H])([H])[H])=C2[H] CN1C=CC(CN2CCC3=CC4=C(C=C3CC2)N=C(N)S4)=N1 [H]OC1=NSC(N([H])C2=C([H])C([H])=C(OC3=C([H])C(Cl)=C([H])C([H])=C3Cl)C([H])=C2[H])=C1\C(=N\C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])N([H])[H] [H]N([H])C1=NC([H])=C(C([H])=N1)C1=NC2=C(C([H])=C(S2)C([H])([H])C2([H])C([H])([H])C([H])([H])N(C([H])([H])C2([H])[H])S(=O)(=O)C([H])([H])[H])C(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N1C(SC([H])([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])[S@](=O)C([H])([H])[H])=NC(=C1C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H] [H]N(C1=NC([H])=C(Cl)C(=N1)C1=C([H])N=C2C([H])=C([H])C([H])=C([H])N12)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C([H])=O)C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]OC(=O)C1=C([H])C([H])=C([H])C([H])=C1C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(SC([H])([H])C([H])([H])C([H])([H])[H])=NN=C1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C(N(N=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C(F)(F)F)C(=O)OC([H])([H])C([H])([H])[H] [H]N1C2=C([H])C([H])=C([H])C([H])=C2C(=C1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C(=O)N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] CC1=CC=C2CCC(=O)C3=C2C1=CC=C3 [H]N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=NC(C2=NC(Br)=C([H])S2)=C(N1[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])C1=NC(N(C(=N1)N([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] CCC(=O)N1CCC(CC1)NC(=O)NC1=CC=CC(=C1)C(F)(F)F [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)C([H])([H])SC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@]1([H])N(C(=O)C([H])([H])C([H])([H])S[H])C(=O)[C@@]2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@]12[H] [H]N1C([H])=C([H])C2=C1C(F)=C([H])C(=C2[H])S(=O)(=O)C1=C([H])C([H])=C2N(C3=C(C2=C1[H])[C@]1([H])N([H])[C@@]([H])(C([H])([H])C1([H])[H])C3([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C2C(F)=C([H])C([H])=C(OC3=C([H])C4=C(N=C(N(C4=O)C([H])([H])[C@]4([H])C([H])([H])N(C([H])([H])C([H])([H])C4([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])=N3)C2=N1 [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=NC(=NC2=NN(C([H])=C12)C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)[C@]([H])(SC1=NC2=C(C([H])=NN2C2=C([H])C(Cl)=C([H])C([H])=C2[H])C(=O)N1[H])C([H])([H])[H] [H]OC(=O)C([H])([H])C1=C([H])C(Cl)=C(SC([H])([H])C([H])([H])C([H])([H])OC2=C(C3=C(C([H])=C2[H])C(=NO3)C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C(=O)C2=C(O1)C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C(Cl)=C([H])C(Cl)=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N([H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C(=O)OC([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N([H])C(=O)[C@]2([H])N([H])C([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C1([H])[H] [H]SC([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] [H]N([H])C(=S)N([H])N=C1C2=C(C([H])=C([H])C(OC([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])=C2[H])C2=C1C([H])=C(OC([H])([H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])=C2[H] [H]N(C1=C2C(=NC3=C([H])C(Cl)=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])[C@]2([H])C(=O)C3=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C3C2([H])[H])C([H])([H])C1([H])[H] [H]OC(=O)C(\[H])=C(\C(\[H])=C(/[H])\C(\[H])=C(\C1=C([H])C2=C(SC([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])([H])[H])/C([H])([H])[H] [H]O[C@@]1([H])[C@@]([H])(O[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])[H])[C@@]1([H])O[H])N1C([H])=NC2=C1N=C([H])N=C2N([H])C(=O)N([H])C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]O[C@@]1([H])C2=C(C([H])=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])C([H])([H])C([H])([H])N(C1([H])[H])[C@@]1([H])C([H])([H])O[C@@]([H])(OC1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C2=C(OC(=N2)C(=O)[C@]([H])(N([H])C(=O)C([H])([H])N2C(=O)C(N([H])[H])=C([H])N=C2C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]OC(=O)C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(=O)O[H])C([H])([H])C1=C([H])C([H])=C(OS(=O)(=O)O[H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@@]([H])(C([H])([H])[C@]([H])(N([H])S(=O)(=O)C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)[C@@]([H])(O[C@]([H])(C(=O)N1C([H])([H])C([H])([H])C([H])(OC([H])([H])OC([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C1=C(C([H])=C(Cl)C(OC([H])([H])[H])=C1[H])C([H])([H])[H])C1=C(C#N)C([H])=NC2=C([H])C3=C(N=C([H])N3C([H])([H])C([H])([H])N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C([H])=C12 [H]OC(=O)[C@]([H])(C([H])([H])C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C2=C(OC(=N2)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[H])N=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C(C([H])=C(\C([H])=C(/[H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])C([H])=N1)C([H])([H])N([H])C(=O)C1=NO[C@@]([H])(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C1([H])[H] [H]O[C@]([H])(C([H])([H])N(C(=O)C1=C([H])C2=C(N=C(O2)N(C([H])([H])[H])C([H])([H])C#C[H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])N=C([H])S1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1=C(Cl)C([H])=C([H])C(=C1[H])S(=O)(=O)N1C(=O)[C@]([H])(C([H])([H])C2=C([H])C(Cl)=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])C([H])([H])C(=O)C1([H])[H] [H]OC1=C(SC(=N1)C1=C([H])C([H])=C(SC(F)(F)F)C([H])=C1[H])C([H])([H])[H] [H]N(C#N)S(=O)(=O)C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)N(N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1C(F)(F)F [H]C1=C(C([H])=C(N1C([H])(C([H])([H])[H])C([H])([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H])C1=NC([H])([H])C2=C1C(OC([H])([H])[H])=NC([H])=C2[H] [H]OC(=O)[C@]1(O[H])C([H])([H])[C@@]([H])(O[H])[C@@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C(O[H])=C(O[H])C([H])=C2[H])[C@]([H])(OC(=O)C(\[H])=C(/[H])C2=C([H])C([H])=C(O[H])C(O[H])=C2[H])C1([H])[H] [H]N([H])C1=C([H])C(=NN1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1Cl)C1=C(SN=N1)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])[H])C([H])=C1[H] [H]C1=C([H])C(F)=C([H])C2=C1C(=O)N(S2)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)N([H])C([H])([H])[C@]([H])(N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F)C1=C(OC([H])([H])[H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=C([H])C(N3C([H])([H])C([H])([H])N(C4=C([H])C([H])=C(C([H])=C4[H])C(F)(F)F)C([H])([H])C3([H])[H])=C(C([H])=C2C(F)(F)F)[N+]([O-])=O)C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@@]1([H])C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC3=C(C([H])=C(C([H])=C3[H])C3=NC(=C(S3)C(=O)N(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C2C([H])([H])C1([H])[H] [H]OP(=O)(O[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N([H])C1(C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C([H])([H])[C@]2(C#N)C3=C(SC([H])([H])C4=C2C([H])=C([H])C([H])=C4[H])C([H])=C([H])C([H])=C3[H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)[C@@]1([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]2([H])N([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])SSC1([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C(=O)N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])[C@]([H])(O[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])O[H])C([H])([H])O[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] [H]N1C([H])([H])C([H])([H])N(C2=C(C#N)C3=C(N2C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])C2=NC3=C([H])C([H])=C([H])C([H])=C3C(=N2)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=NC2=NC(C3=C([H])C([H])=C([H])C([H])=C3Cl)=C(C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)C([H])([H])[C@]2(C1=O)C(=O)N(C(=O)C1=C2C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(Br)C([H])=C1[H] [H]OC(=O)[C@]([H])(N([H])S(=O)(=O)C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])OC([H])=C1[H] [H]N(C1=C([H])N=C([H])C([H])=C1[H])S(=O)(=O)C1=C(OC([H])([H])C([H])([H])[H])C([H])=C([H])C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C2=C1C([H])([H])C([H])([H])[C@@]1([H])N(C([H])([H])C([H])=C([H])[H])C([H])([H])C([H])([H])[C@@]21[H] [H]C1=C(N=C(N1C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])N(C2=C([H])C(Cl)=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])[C@]([H])(C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])C1([H])[H] [H]N=C(N([H])[H])N([H])\N=C(\C1=C([H])C(=C([H])C(N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])=C1[H])C(=N\N([H])C(=N[H])N([H])[H])\C([H])([H])[H])C([H])([H])[H] [H]O[C@@]1([H])C([H])([H])C([H])([H])[C@]2([H])[C@@]3([H])C(=C([H])C([H])([H])[C@]12C([H])([H])[H])N1C(=C([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])C3([H])[H] [H]OC(=O)[C@@]([H])(OC1=NC(OC([H])([H])[H])=C([H])C(=N1)C([H])([H])[H])C(OC([H])([H])C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C([H])([H])C([H])([H])OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])OC1=C([H])C([H])=C(F)C([H])=C1[H] [H]N1C(=O)S[C@@]([H])(C1=O)C([H])([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C(C([H])=N2)C(F)(F)F)C([H])=C1[H] [H]N1C(=C([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)C1=C([H])C2=C(N1[H])C([H])=C([H])C(OC(=O)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])=C2[H] [H]N1C([H])([H])C([H])([H])[C@]([H])(C2=C([H])C(=O)N(C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C(=O)N(C([H])([H])C2=C([H])C(=C([H])C(=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])C2([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N(C1=NC(=C([H])C([H])=N1)N1C([H])([H])C([H])([H])C([H])([H])[C@]([H])(C(=O)N([H])C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H])C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C([H])([H])N(C2=C([H])C(Cl)=C(Cl)C([H])=C2[H])C([H])([H])[H])[C@@]([H])(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C1([H])[H] [H]N1C([H])=NC2=C1C([H])([H])[C@]([H])(C(=O)C1=C([H])N(C3=C1C([H])=C([H])C([H])=C3[H])C([H])([H])[H])C([H])([H])C2([H])[H] [H]C1=C([H])C([H])=C2N(C(=NC2=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N(C([H])([H])[H])[C@@]1([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])N([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(N([H])C(=S)N([H])C2=C([H])C([H])=C(F)C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1OC([H])([H])[H])C1=C([H])C(F)=C(OC2=C3SC(=C([H])C3=NC([H])=C2[H])C2=C([H])N(C([H])=N2)C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])N1C(=NC2=C1C([H])=C([H])C([H])=C2[H])C1=C([H])C([H])=C([H])C([H])=N1)C1=C([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])[C@@]1([H])C2=C3OC(=NC3=C([H])C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H] [H]C(=C(Br)Br)C1=C([H])C([H])=C(C([H])=C1[H])[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)OC([H])([H])[H] [H]N1N=NN=C1C1=C([H])C(F)=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F CC(C)(C)NC(=O)NCCN1CCN(CC(=O)NC2=CC(Cl)=CC(Cl)=C2)CC1 [H]N(C1=NC(Cl)=C([H])N(C1=O)[C@]([H])(C([H])([H])[H])C1([H])C([H])([H])C1([H])[H])C1=C(Cl)C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H] [H]N1C([H])=NC2=C1C([H])=C(C([H])=C2Cl)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=NC([H])=C([H])C([H])=N2)C([H])([H])C1([H])[H] [H]N(\N=C1/C(=O)N([H])C2=C([H])C([H])=C([H])C([H])=C12)C(=O)C([H])([H])N(C1=C([H])C([H])=C(Cl)C([H])=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)N1C([H])([H])C([H])([H])[C@](C2=C([H])C([H])=C(Cl)C(Cl)=C2[H])(C([H])([H])C([H])([H])N2C([H])([H])C([H])(N3C([H])([H])C([H])([H])OC([H])([H])C3([H])[H])C2([H])[H])C1([H])[H] [H]O[C@@]1(OC(=O)C(=C1C1=C([H])C([H])=C(C([H])=C1[H])S(=O)(=O)C([H])([H])[H])C1=C([H])C(F)=C([H])C(F)=C1[H])C([H])([H])[H] [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C2=NC([H])=C(C([H])=C2Cl)C(=O)N([H])C2=NC(=C(S2)C([H])([H])C([H])([H])[H])C2=C([H])C([H])=C(F)C(=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C(=O)C([H])([H])N2C(=O)C([H])([H])C([H])([H])[C@@]2([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC([H])=C1[H] [H]ON(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C2=C([H])C(OC3=C([H])C([H])=C([H])C([H])=C3[H])=C([H])C([H])=C2OC1([H])[H] [H]O[C@]1(N2C(=NC([H])([H])C2([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N([H])[C@]1([H])C([H])([H])N(C2=NC3=C(C([H])=NN(C3=O)C([H])([H])[H])N2C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C#N)C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C(=O)C1=C([H])C([H])=C(N([H])C(=O)C([H])([H])OC2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C3=C(N2[H])C(=O)N(C(=O)N3C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] CCOC(=O)C1=C(CC)N2N=C(C=C(C2=C1C(=O)OCC)C1=CC=CC=C1)N1CCOCC1 [H]OC1=C(\N=N\C2=C(O[H])C([H])=C(C3=C2C([H])=C([H])C([H])=C3[H])S(=O)(=O)O[H])C(=NN1C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])=C1C(=O)N(C(=O)C1=C2[H])[C@]([H])(C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C(=O)OC([H])([H])[H] [H]N(C([H])([H])C1=NC([H])=C2OC([H])([H])SC2=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])C2=C3C([H])=C(OC([H])([H])[H])C([H])=C([H])C3=NC([H])=C2C#N)C([H])([H])C1([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])[C@]([H])(C1=C([H])C([H])=C([H])C([H])=C1C([H])=C2N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=C(C(=C1[H])C([H])([H])[H])C([H])([H])[C@]([H])(N([H])[H])C(=O)N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N(C([H])([H])C(=O)N([H])[H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H])C([H])([H])[H] [H]N(\C([H])=C1/C(=O)N([H])C(=O)C2=C([H])C([H])=C(C([H])=C12)C1=C([H])OC([H])=C1[H])C1=C([H])C(F)=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)OC([H])([H])[C@@]([H])(N([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C([H])([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C2N([H])C(=O)C(C3=C([H])C(=NO3)C([H])([H])[H])=C(C2=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=NSC(N([H])C2=C([H])C([H])=C(N([H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])=C1C(=N[H])N([H])C([H])([H])[C@]([H])(O[H])C([H])([H])O[H] [H]C1=C([H])C(F)=C(C(=O)N2C([H])([H])C([H])([H])C([H])(N(C([H])([H])C3=C(N(N(C3=O)C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C3=C([H])C([H])=C(F)C([H])=C3[H])C([H])([H])C2([H])[H])C(F)=C1[H] C[C@@H](NC(=O)C1=CNC2=NC=C(N=C12)C1CC1)C(=O)N1CCC(C)C1 [H]C1=C([H])C(OC([H])([H])C([H])([H])OC2=NC3=C(N2C([H])([H])[H])C(=O)N(C(=O)N3C([H])([H])[H])C([H])([H])[H])=C([H])C([H])=C1Cl [H]N(C1=C2N=C([H])N([H])C2=NC(=N1)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]OC([H])([H])C([H])([H])N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1N([H])[H])C1=C([H])C([H])=C([H])S1)C([H])([H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C(=O)C([H])=C([H])\C1=C(\[H])N([H])N([H])C(=O)C([H])([H])N([H])C(=O)C(\[H])=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C([H])C(=C([H])C(=C1S2(=O)=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])N(C2=C([H])C(OC([H])([H])[H])=C([H])C([H])=C2OC([H])([H])[H])C([H])([H])[H])C(=N1)N([H])[H] [H]N(C(=O)C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C(Cl)C(Cl)=C([H])C(=C1[N+]([O-])=O)C([H])([H])C(=O)N(C([H])([H])[H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=C(C(=O)C2=C([H])C([H])=C(Cl)C([H])=C2[H])C(=C([H])S1)C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Br)C1=C(C2=NN=C(O2)C([H])([H])[H])C(=NN1C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C1=NN=C(O1)C1(C([H])([H])C1([H])[H])C(F)(F)F [H]N1C(C2=C([H])C([H])=C([H])C([H])=C2[H])=C(C(=O)OC([H])([H])C([H])([H])[H])[C@]([H])(C(C(=O)SC([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C([H])=C([H])C([H])([H])N1C(=NC2=C1C(=O)N(C(=O)N2C([H])([H])[H])C([H])([H])C([H])=C([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C1(C2=C([H])C([H])=C(C([H])=C2[H])C2=C(C3=C([H])C([H])=C([H])C([H])=C3[H])C3=C(C([H])=NC([H])=C3[H])C([H])=N2)C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])OC(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C1=NC([H])=C(S1)[N+]([O-])=O [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@]([H])(N2C(=O)C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C(=O)N(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])C1=NC(N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])=C2N=C([H])N(C2=N1)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(OC([H])([H])[H])N=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]([H])(SC1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C(N([H])C(=N[H])N([H])[H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])N=C1[H] [H]ON(C(=O)OC([H])([H])[H])[C@]([H])(C#CC1=NN(C(=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]C1=C([H])C2=C(C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1N2C([H])([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]12[H] [H]N(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C(C([H])=C([H])C([H])=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])=NC(=C1C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C2=C(N=C([H])N=C2C([H])=C1[H])N([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C([H])([H])OC1=C([H])C([H])=C([H])C([H])=C1F)C1=NN=C(O1)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]N(C(=O)C1=C([H])C([H])=C(S1)C1=C([H])C([H])=C([H])S1)[C@@]1([H])[C@@]([H])([N@]2C([H])([H])C([H])([H])[C@]1([H])C([H])([H])C2([H])[H])C([H])([H])C1=C([H])C([H])=C([H])N=C1[H] [H]N(C(=O)C1=C([H])C2=C(N=C(C3=C([H])C([H])=C([H])O3)C(=N2)C2=C([H])C([H])=C([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C([H])([H])C([H])([H])N([H])[C@@]1([H])C(=O)N(C(=O)C1([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])C3(C4=C([H])C([H])=C([H])C([H])=C4C([H])([H])C3([H])[H])C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])C([H])([H])N(C2=C([H])C(O[H])=C([H])C([H])=C2C1([H])[H])C([H])([H])C([H])([H])[H] [H]N(C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C(=C2[H])C(=O)N([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1=NOC(=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)(O[H])OC([H])([H])[C@@]1([H])O[C@@]([H])(N2C([H])=NC3=C2N=C([H])N=C3N([H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@]2([H])O[C@@]([H])(O[C@]12[H])C(\[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=O)N(C(=O)C1(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N(C(=O)[C@@]([H])(N([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=NN1[H])C([H])([H])C#N OP(O)(=O)C(NC1=CC(CC2=CC=CC=C2)=CN=C1)P(O)(O)=O [H]C1=NC([H])=C(C([H])=C1OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])[C@]2([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@]([H])(C1([H])[H])C2([H])[H] [H]N(C1=NC2=C(C([H])=C([H])C([H])=C2[H])C2=C([H])N(N=C12)C1=C([H])C([H])=C([H])C(=C1[H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C(=O)N1C2=C(SC([H])=C2[H])C2=NN(C([H])=C2C([H])([H])C1([H])[H])C([H])([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[C@]1([H])N([H])C(=O)C([H])([H])C([H])([H])SSC([H])([H])[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C1=O)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C(=O)N([H])[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])[C@]1([H])C(=O)N([H])[C@]([H])(C(=O)N([H])C([H])([H])C(=O)N([H])[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H] [H]N([H])C(=N/C(=O)C1=C([H])C([H])=C([H])C(F)=C1C([H])([H])C([H])([H])C1=C([H])C(Br)=C([H])C([H])=C1OC([H])([H])[H])\N([H])C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(N([H])C(=O)OC([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N([H])C(=O)C([H])([H])[C@]1([H])ON=C(C1([H])[H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]O[P@](=O)(C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C([H])([H])[C@]([H])(C(=O)N([H])[C@@]([H])(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]O[C@]([H])(C(\[H])=C(/[H])C(C#N)=C(C1=C([H])C([H])=C(F)C([H])=C1[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]N1C(=O)C2=C([H])C([H])=C([H])N=C2N=C1C([H])([H])OC([H])([H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H] [H]N(C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C([H])=C1OC1=C([H])C([H])=C(Cl)C([H])=C1[H])C(=O)N1C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C([H])([H])OC([H])([H])[C@@]12C(=C([H])C3=C(C([H])=NN3C3=C([H])C([H])=C(F)C([H])=C3[H])C1([H])[H])C([H])([H])C([H])([H])N(C2([H])[H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])[C@@]([H])(C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1[H])C([H])([H])[H] [H]N(C(=O)OC([H])([H])C([H])([H])C([H])([H])C1=C([H])N([H])C([H])=N1)C1=C([H])C([H])=C(C([H])=C1[H])[N+]([O-])=O [H]N(C(=O)C1=C([H])N(C(=O)C([H])=C1[H])C([H])([H])C([H])([H])OC([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N(C(=O)C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C([H])=C([H])C([H])([H])OC1=C([H])C(=O)OC2=C([H])C([H])=C([H])C([H])=C12 [H]ON([H])C(=O)[C@]([H])(N(C([H])([H])C1=C([H])C([H])=C2OC([H])([H])OC2=C1[H])S(=O)(=O)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C1=C([H])N=C([H])N1C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)C1=C([H])N(C2=C(C([H])=C(F)C(=N2)N2C([H])([H])[C@]([H])(N([H])[H])[C@]([H])(C3=C([H])C([H])=C(C([H])=C3[H])C([H])(C([H])([H])[H])C([H])([H])[H])C2([H])[H])C1=O)C1([H])C([H])([H])C1([H])[H] [H]C1=NC2=C(C([H])=C([H])C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C(OC([H])([H])[H])C(C(=O)C2=NC(=NC(=C2[H])N(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C2([H])C([H])([H])C2([H])[H])C([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N1C2=C(C3=C1C([H])([H])C1(N([H])C3=O)C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C2C([H])=C(N=C1[H])C1=C([H])N=C(F)C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C([H])=C(C([H])=C1[H])C(=C(F)F)C1=C([H])C([H])=C([H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC2=C(N=C(C([H])=C2[H])C([H])([H])N([H])C2=C([H])C(Cl)=C(Cl)C(Cl)=C2[H])C(=N1)N([H])[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])N(C([H])([H])[C@@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C1=C([H])C(=NC2=C([H])C([H])=C([H])C([H])=C12)C([H])([H])[H])S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N([H])C(=O)N([H])C1=C2C(=O)C3=C(N([H])N=C3C2=C([H])C([H])=C1[H])C1=C(C([H])=C([H])S1)C([H])([H])[H] [H]N(C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])=C([H])C(OC([H])([H])C2=C([H])C([H])=C(F)C([H])=C2[H])=C([H])C1=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC1=C2O[C@]3([H])[C@@]45C2=C(C([H])=C1[H])C([H])([H])[C@@]([H])(N(C([H])([H])C1([H])C([H])([H])C1([H])[H])C([H])([H])C4([H])[H])[C@@]51C([H])=C([H])[C@]3(OC([H])([H])[H])[C@@]2([H])C([H])([H])C([H])([H])[C@]([H])(O[H])[C@@]12[H] [H]ON(C(=O)[C@@]1([H])C([H])([H])C([H])([H])[C@@]2([H])[C@]3([H])C([H])([H])N([H])C4=C([H])C(=O)C([H])([H])C([H])([H])[C@]4(C([H])([H])[H])[C@@]3([H])C([H])([H])C([H])([H])[C@]12C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(N(C(=O)OC([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)C1=C(OC([H])([H])[H])C(=NC2=C([H])C(F)=C([H])C([H])=C12)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C2C3=C1O[C@@]1([H])C4=C(C5=C(N4[H])C([H])=C([H])C([H])=C5[H])C([H])([H])[C@@]4([H])[C@]([H])(N(C([H])([H])C([H])([H])C5=C([H])C([H])=C([H])C([H])=C5[H])C([H])([H])C([H])([H])[C@]314)C2([H])[H] [H]N(C(=O)C1=C([H])C([H])=C(Cl)S1)[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]1([H])N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1(C([H])([H])N2C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C(=C1C1=C([H])C(=C([H])C([H])=C1[H])N1C([H])([H])C([H])([H])N(C2=C([H])C([H])=C(N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C(Cl)=C3[H])C([H])=C2[H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H] [H]O[C@]([H])(C([H])([H])[H])[C@]([H])(N([H])[H])C1=NC2=C([H])C(=C([H])C([H])=C2N1[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N(C1=C2N=C([H])N(C2=NC(=N1)C1=C([H])C([H])=C(C([H])=O)C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] [H]N(C1=C2C([H])=C(C([H])=C([H])C2=NC([H])=N1)C1=C([H])C2=C(OC([H])([H])C([H])([H])O2)C([H])=C1[H])C([H])([H])C1=C([H])C(=C([H])S1)C([H])([H])[H] [H]OC(C1=C([H])C([H])=C([H])C([H])=C1[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])[C@@]1([H])C([H])([H])C2([H])N(C([H])([H])[H])[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] FC(F)(F)OC1=CC=C(NC2=NC=NC(=C2)N2CCOCC2)C=C1 [H]N([C@]1([H])C(=O)N(C([H])([H])C1([H])[H])[C@]([H])(C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])[H])S(=O)(=O)C1=C([H])C2=C([H])C([H])=C(Cl)C([H])=C2C([H])=C1[H] [H]ON(C(=O)C(\[H])=C(/[H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C(C([H])=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(N2C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N3C(=O)C([H])([H])C4(C([H])([H])C([H])([H])C([H])([H])C4([H])[H])C([H])([H])C3=O)C([H])([H])C2([H])[H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C1[H] [H]C([H])([H])[S@+]1C([H])([H])C2=C(ON=C2OC([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C([H])C([H])=C1C([H])([H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C2C(=NC3=C([H])C([H])=C([H])C([H])=C13)C([H])([H])C([H])([H])C([H])([H])C2([H])[H] [H]N(C(=O)C1=C(N(C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(C(=C([H])C([H])=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H] [H]\C(=C(\[H])C1=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C(=O)N1N=C(C2=C1C([H])([H])[C@]1([H])[C@@]2([H])C1(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1(N([H])C(=O)C([H])([H])[H])C([H])([H])C1([H])[H])[C@@]([H])(C1=C(F)C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C(F)=C1C(=O)OC([H])([H])[H])C([H])([H])[H] [H]OC([H])([H])C1=NC([H])=NN1C1=C([H])N2C(=NC(=C2C([H])([H])[H])C([H])([H])[H])C(N([H])C([H])([H])C2=C(C([H])=C([H])C([H])=C2C([H])([H])[H])C([H])([H])[H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@]([H])(O[H])C([H])([H])N1C([H])([H])C([H])([H])C([H])(C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]C1=C([H])C(OC([H])(C([H])([H])[H])C([H])([H])[H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C([H])([H])N2C(=O)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=NC2=C([H])C(Cl)=C(C([H])=C2C(OC([H])([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])[N+]([O-])=O [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])([H])N(C([H])([H])C1([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1[H] [H]C1=C([H])C(OC([H])([H])[H])=C(C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C(=O)C2=C([H])C(OC(F)(F)F)=C([H])C([H])=C12 [H]OC1=C(C(OC([H])([H])[H])=C(C2=C1C(=O)OC2([H])[H])C([H])([H])[H])C([H])([H])C(\[H])=C(/C([H])([H])[H])C([H])([H])N(C(=O)C([H])([H])[H])C([H])([H])C([H])([H])P(=O)(O[H])O[H] [H]N(C(=O)C([H])([H])N1C2=C([H])C([H])=C(C([H])=C2C([H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C(=O)N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)C1=C(Cl)C2=C(N=C1[H])N(N=C2[H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])C([H])([H])[H])C1=C([H])N=C(OC2=C([H])C([H])=C(C([H])=C2[H])C([H])([H])N([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N(C(=O)OC1=C([H])C([H])=C([H])C(=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H][C@@]12C[C@H](C[C@@]1(C[C@@H](C2)C(F)(F)F)C(=O)N1CCC2=C(C1)C=C(C=N2)C(F)(F)F)NC1CCOCC1OC [H]N1N=NN=C1C1=C([H])C(F)=C([H])C(=C1[H])N(C(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C(F)(F)F [H]C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N(C1([H])C([H])([H])C1([H])[H])C1([H])C([H])([H])C([H])([H])N(C(=O)C2=C(C([H])=C([H])C(F)=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]N(C([H])([H])C([H])([H])[H])[C@@]1([H])C([H])([H])[C@@]2([H])C([H])([H])C([H])([H])[C@]1(C([H])([H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C3=C([H])C([H])=C(C([H])=N3)C(F)(F)F)C([H])([H])C1([H])[H])C2(C([H])([H])[H])C([H])([H])[H] [H]OP(=O)([C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@@]([H])(N([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N1C(=NC2=C([H])C(=C([H])C([H])=C12)S(=O)(=O)C([H])([H])C([H])([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C(=O)OC([H])([H])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)OC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)C(F)(F)C(=O)N([H])C([H])([H])[C@@]([H])(C([H])([H])[H])C([H])([H])C([H])([H])[H])C([H])([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@@]([H])(O[H])C1=C(SC([H])([H])[H])N=C(N1C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)N([H])C(=O)N([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])[H] CC(C)(C)NC(=O)C1=CNC2=C1N=C(C=N2)C1=NN(C2CCNCC2)C2=C1C=CC(F)=C2 [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2N(C)C(=O)CC[C@]12C [H]OC(=O)C1=C([H])C(Cl)=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C([H])C(=C1[H])S(=O)(=O)N1C([H])=C([H])C2=C1C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])[H] [H]N(C(=O)[C@]1([H])C2=C([H])C([H])=C([H])C(OC([H])([H])[H])=C2C([H])([H])C([H])([H])C1([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C(OC([H])([H])[H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1N=C(OC1=O)C1=C(C([H])=C(OC([H])([H])C2=C([H])C([H])=C3C([H])=C([H])C([H])=C([H])C3=N2)C([H])=C1[H])[C@@]1(C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]([H])(C([H])([H])[H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])N=C1N([H])C(=O)N([H])C1=C([H])C([H])=C([H])C2=C1[C@]1([H])N(C2=O)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]ON([H])C(=O)[C@@]1(N([H])S(=O)(=O)C2=C([H])C([H])=C(OC3=C([H])C([H])=C(Cl)C([H])=C3[H])C([H])=C2[H])C([H])([H])[C@@]2([H])O[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]O[C@@]1(C2=C([H])C([H])=C(N=C2[H])C([H])([H])[H])C([H])([H])C([H])([H])[C@]([H])(N2C([H])([H])C([H])([H])[C@@]([H])(N([H])C(=O)C([H])([H])N([H])C(=O)C3=C([H])C([H])=C([H])C(=C3[H])C(F)(F)F)C2([H])[H])C([H])([H])C1([H])[H] [H]OC1=C(OC([H])([H])[H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C2C([H])([H])C([H])([H])[C@@]2(C(=O)C([H])([H])[C@]3([H])C([H])([H])[C@]123)C([H])([H])[H] OC1=CC=CC=C1C(=O)\C=C\C=C\C1=CC=C(C=C1)[N+]([O-])=O [H]N1C([H])([H])C([H])([H])N(C(=O)C2=C(OC3=C([H])C(F)=C([H])C([H])=C3C([H])([H])[H])N(C3=NC([H])=C([H])C([H])=C23)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C2=C(ON=C2C2([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C2([H])[H])N=C1C1=C([H])C([H])=C(C([H])=C1OC([H])([H])[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]N([H])C1=NC(=C([H])S1)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C2=C3C([H])=C([H])C([H])=C([H])C3=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC([H])([H])[C@@]([H])(O[H])C([H])([H])OC1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C1=C([H])C(N([H])C3=C(F)C([H])=C(F)C([H])=C3[H])=C([H])C([H])=C1C2=O [H]OC(=O)C1=C([H])C2=C(OC([H])([H])C3=C(C([H])=C([H])C([H])=C3[H])\C2=C(\[H])C([H])([H])N2C([H])=NC3=C2C([H])=C(OC([H])([H])[H])C([H])=C3[H])C([H])=C1[H] [H]N1C(C(=O)OC([H])([H])C([H])([H])C([H])([H])[H])=C(C2=C1C([H])([H])[C@]([H])(C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C1[H])C([H])([H])C2=O)C([H])([H])[H] [H]O[C@]([H])(C([H])([H])OC1=C(OC([H])([H])[H])C([H])=C2N=C([H])N=C(N([H])C3=C([H])C(Cl)=C(F)C([H])=C3[H])C2=C1[H])C([H])([H])N([H])[H] [H]OC1=C2N=C([H])C([H])=C([H])C2=C([H])C(=C1[H])[N+]([O-])=O [H]N([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])N([H])C(=O)C1=C([H])C2=C(O1)C(OC([H])([H])[H])=C([H])C([H])=C2C([H])([H])N1C([H])([H])C2=C(C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N1C(=O)C(C2=C([H])OC3=C([H])C([H])=C([H])C([H])=C23)=C(C1=O)C1=C([H])N(C2=C(C([H])=C([H])C([H])=C12)C([H])([H])C([H])([H])C(=O)OC([H])([H])C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N([H])[C@](C1=O)(C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])N1C(=O)C2=C(C([H])=C([H])C(OC([H])([H])[H])=C2[H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C(OC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])C(=O)C2=C(O[H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2O1 [H]N([H])S(=O)(=O)C1=NC2=C([H])C([H])=C(OC([H])([H])C([H])([H])OC(=O)C([H])([H])[N+]3=C(C([H])=C(C([H])=C3C([H])([H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[H])C([H])=C2S1 [H]OC1=C([H])C([H])=C(C([H])=C1[H])[C@@]1([H])OC2=C(C([H])=C(O[H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])C([H])([H])N([H])C1=C(C2=C(S1)C([H])([H])C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1=NN=C(SC([H])([H])C(=O)OC([H])([H])[H])N1N([H])C(=O)C([H])([H])[H] [H]OC1=C([H])C(O[H])=C(C([H])=C1C1=C(C(=NO1)C(=O)N([H])C([H])([H])C([H])([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON([H])C(=O)[C@@]1([H])C([H])([H])C([H])([H])C([H])([H])OC(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]1([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1S(=O)(=O)C([H])([H])[H])C(=O)N([H])C([H])([H])C(=O)N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] [H]N(C(=O)C([H])([H])C1=C(N([H])N=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N1C(=NC2=C1C(=O)N(N=C2C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(O[C@@]2([H])C([H])([H])N([H])C([H])([H])C2([H])[H])C([H])=C1OC([H])([H])[H] [H]C1=NC([H])=C(N1C([H])([H])[H])[C@@]([H])(C1=C([H])C([H])=C(Cl)C([H])=C1[H])C1=C([H])C([H])=C2N(C(=O)C([H])=C(C3=C([H])C(Cl)=C([H])C([H])=C3[H])C2=C1[H])C([H])([H])[H] [H]N=C(N([H])[H])N1C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C([H])([H])[C@]([H])(N([H])C(=O)C([H])([H])N2C(=O)C([H])([H])N(C(=O)[C@@]2([H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])C(=O)C2=NC([H])=C([H])S2)C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)N1C(=NC(C2=NN=C(S2)C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])=C1C([H])([H])[H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl [H]OC(=O)C1([H])C([H])([H])C([H])([H])N(C([H])([H])C1([H])[H])[C@@](C#CC1=NC([H])=NC2=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C12)(C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C2C(OC3=C2N=C(N=C3Cl)C([H])([H])[H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=N1)[C@]([H])(C#N)N1C([H])([H])C([H])([H])N(C(=O)C2=C([H])C([H])=C([H])C([H])=C2[H])C([H])([H])C1([H])[H] [H]OC(C([H])([H])[H])(C([H])([H])[H])[C@@]([H])(N([H])C1=NC([H])=C([H])C(=N1)N(C(=O)N([H])C1=C([H])C([H])=C([H])C([H])=C1Cl)C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])[H] [H]N([H])[C@]1([H])C([H])([H])C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C([H])([H])C([H])([H])C([H])([H])C2=C([H])N([H])C3=C2C([H])=C([H])C([H])=C3[H])C([H])([H])C(\Cl)=C(/[H])C2=C([H])C([H])=C([H])C([H])=C2[H])C1([H])[H] [H]N1C([H])([H])C(=O)N(C2=C([H])C([H])=C(OC([H])([H])C([H])([H])C([H])([H])OC([H])([H])C3=C(OC([H])([H])[H])C([H])=C([H])C([H])=C3[H])C([H])=C2[H])[C@@]([H])(C([H])([H])OC([H])([H])C2=C([H])C(=C([H])C([H])=C2[H])C(F)(F)F)C1([H])[H] [H]N([H])C([H])([H])C1=C(N=C(C(=C1C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])[H])C([H])([H])C(=O)N([H])C1=C([H])C(=C([H])C([H])=C1[H])C(=O)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N([H])C1=NC([H])=NC2=C([H])C(=C([H])C([H])=C12)C([H])([H])N1C(=O)C([H])([H])N(C([H])([H])C2=NC3=C(N2[H])C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]C1=NC(=C([H])C([H])=C1[H])C1=NN=C(O1)S(=O)(=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]N([H])C(=O)C1=C([H])C([H])=C([H])C2=C1N=C(N2[H])[C@@]1(N([H])C(=O)C([H])([H])C1([H])[H])C([H])([H])[H] [H]N1C([H])=NC(=C1C([H])([H])[H])C([H])([H])C1=NC(=C([H])S1)C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 [H]N([H])S(=O)(=O)C1=C([H])C(=C(Cl)C(Cl)=C1N([H])S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)S(=O)(=O)N([H])[H] [H]N([H])C1=C(Cl)C([H])=C(C(=O)OC([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C([H])([H])C([H])([H])C([H])([H])N([H])S(=O)(=O)C3=C([H])C([H])=C([H])C4=C3C([H])=C([H])C([H])=C4N(C([H])([H])[H])C([H])([H])[H])C([H])([H])C2([H])[H])C(OC([H])([H])[H])=C1[H] [H]N(C(=O)C1=C(C([H])=C(N([H])C([H])([H])C2=C([H])N=C([H])N2C([H])([H])C2=C([H])C([H])=C(C#N)C([H])=C2[H])C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] [H]C([H])=C([H])C([H])([H])C1(C(=O)N(C(=O)C2=C([H])C([H])=C([H])C([H])=C12)C1=C([H])C([H])=C(Cl)C([H])=C1[H])C([H])([H])C([H])=C([H])[H] [H]OC1=NC2=C([H])C(F)=C([H])C([H])=C2N1C1([H])C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])N2C(=O)C3=C([H])C([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C1([H])[H] [H]C1=C([H])C([H])=C(C([H])=N1)C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O[C@@]1([H])O[C@]([H])(C2=C([H])C([H])=C(OC([H])([H])[H])C(OC([H])([H])[H])=C2[H])C([H])([H])C1([H])[H] [H]N(C1=C([H])C2=C(C([H])=C1[H])N(N=C2[H])C([H])([H])C1=C([H])C(F)=C([H])C([H])=C1[H])C1=NC([H])=NN2C([H])=C([H])C(=C12)C([H])([H])N1C([H])([H])C([H])([H])C([H])(N([H])C([H])([H])C([H])([H])S(=O)(=O)C([H])([H])[H])C([H])([H])C1([H])[H] [H]OC1=C2C([H])=C([H])C([H])=C([H])C2=C2N([H])C(=C(C(=O)OC([H])([H])C([H])([H])[H])C2=C1[H])C1=C([H])C([H])=C([H])C(Cl)=C1[H] [H]N(C1=NC([H])=C2C([H])=C([H])C(=O)N(C2=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C([H])=C(C([H])=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]OC(=O)C([H])([H])[C@]1([H])SC2=C(N([H])C1=O)C([H])=C(S2)S(=O)(=O)N([H])[H] [H]N(C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])[C@]1([H])C([H])([H])N(C(=O)N2C([H])([H])C([H])([H])[C@]([H])(N(C(=O)C3=C([H])C([H])=C(C([H])=C3[H])C3=C([H])C([H])=C(OC([H])([H])[H])N=C3[H])C([H])([H])[H])C2([H])[H])C([H])([H])C1([H])[H] [H]O[C@]1(C2=C([H])C([H])=C(Cl)C([H])=C2[H])C([H])([H])[C@@]2([H])N(C([H])([H])C3=C([H])N([H])C4=NC([H])=C([H])C([H])=C34)[C@]([H])(C([H])([H])C2([H])[H])C1([H])[H] [H]N(C(=O)C([H])([H])N1C(=O)N2C3=C(C([H])=C(C([H])=C13)C([H])([H])[H])N(C(=O)C2([H])[H])C([H])([H])[H])C1=C([H])C([H])=C2C(=C1[H])C([H])([H])[C@]1(N(C(=O)N([H])C1=O)C([H])([H])[H])C2([H])[H] [H]N(C1=C([H])C(=NS1)C([H])([H])[H])C1=NC(=C([H])N2C1=NC([H])=C2C1=C([H])N([H])N=C1[H])C(=O)N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C([H])N=C([H])N(C1=O)C([H])([H])C1=C([H])C([H])=C(F)C(F)=C1[H])C([H])([H])C#CC1=C([H])C([H])=C2N=C([H])C([H])=C(N([H])C([H])([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])C2=C1[H] NC(=O)NC1=CC(OCC(O)CNC2CCN(CC2)C2=NC=NC3=C2C(=CS3)C2=CC=CC=C2)=CC=C1 [H]N(C([H])([H])C([H])([H])C([H])([H])OC([H])([H])[H])S(=O)(=O)C1=C([H])C([H])=C2C(=C1[H])C([H])([H])N([H])[C@]([H])(C2([H])[H])C([H])(F)F [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N1C(=O)C2=C(C([H])=C(C([H])=C2[H])[N+]([O-])=O)C1=O [H]OC1=C([H])C2=C(C([H])=C1[H])C([H])([H])[C@@]1([H])N(C([H])([H])[C@]3([H])C([H])([H])[C@]3(C(=O)N([H])C([H])([H])C(=O)N([H])[C@@]([H])(C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C3=C([H])C([H])=C([H])C([H])=C3[H])C([H])([H])C([H])([H])[C@]2(C([H])([H])[H])[C@@]1([H])C([H])([H])[H] [H]N(C([H])([H])C1=NN(C(=C1C([H])([H])[H])C1=C([H])N=C(C([H])=C1[H])C(F)(F)F)C1=C(Cl)C([H])=C([H])C([H])=N1)C1([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C([H])C(=C1[H])[C@](O[H])(C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])N1C([H])([H])C([H])([H])N(C([H])([H])C2=C([H])C([H])=C(C([H])=C2[H])S(=O)(=O)C([H])([H])[H])C([H])([H])C([H])([H])C1([H])[H] [H]N(C(=O)C1=C(N(C2=C([H])C(OC3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C([H])C([H])=C12)C([H])([H])C1=C([H])C([H])=C([H])C([H])=N1)C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])N=C([H])C(F)=C1[H] [H]OC(=O)C(SC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])N(C(=O)N([H])C1=C(OC([H])([H])[H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C([H])([H])C([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C([H])C([H])=C1[H])(C([H])([H])[H])C([H])([H])[H] [H]OC(=O)C([H])([H])OC1=C(C([H])=C(C([H])=C1[H])C([H])([H])N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@]1([H])C(=O)N([H])C1=C([H])C([H])=C(Cl)C([H])=C1Cl)C([H])([H])[H] N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N1CCN(CC1)C1=C2C=CC(F)=CC2=NC=N1 [H]OC(=O)C1=C([H])C(=C([H])C([H])=C1OC1=NC(OC2=C([H])C([H])=C([H])C(=C2[H])C(=N[H])N([H])[H])=C(F)C(N(C([H])(C([H])([H])[H])C([H])([H])[H])C([H])(C([H])([H])[H])C([H])([H])[H])=C1F)C1=C([H])C([H])=C([H])C([H])=C1[H] [H][C@@]12C[C@H](OC(=O)C3=CC=C(OC)C=C3)[C@@]3(C)OC4=C([C@H](O)[C@]3([H])[C@@]1(C)CC[C@H](OC(C)=O)[C@@]2(C)COC(C)=O)C(=O)OC(=C4)C1=CN=CC=C1 [H]C1=C2C(=O)C3=C(C([H])=C([H])C([H])=C3[H])C2=NC(=N1)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]ON(C(=O)[C@]([H])(C1=C([H])C2=C(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3C2=O)C([H])=C1[H])C([H])([H])[H])C([H])([H])[H] [H]O[C@@]([H])([C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C(=O)N([H])[C@@]1([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])O[H])[C@@]([H])(O[H])[C@@]([H])(OC([H])([H])C(\[H])=C(/[H])Br)C1=NN=C(O1)C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]OC1=C([H])N=C([H])C(=C1[H])N1C([H])([H])C([H])([H])N([H])C([H])([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1Cl)[C@]1([H])C([H])([H])[C@]2([H])N(C([H])([H])[H])[C@@]([H])(C([H])([H])C2([H])[H])[C@@]1([H])C(=O)N(OC([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C(=C1[H])C1=C(OC([H])([H])[H])C([H])=C(F)C(=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])N1C(=O)O[C@]([H])(C2=C([H])C(=C([H])C(=C2[H])C(F)(F)F)C(F)(F)F)[C@]1([H])C([H])([H])[H] [H]C1=C([H])N(N=N1)C1=C([H])C(=C([H])C(=C1[H])C(F)(F)F)S(=O)(=O)N1C([H])([H])C([H])([H])N(C(=O)[C@]2([H])C([H])([H])[C@@]2([H])C2=C([H])C([H])=C(C([H])=C2[H])C(F)(F)F)C([H])([H])C1([H])[H] [H]O[C@@]([H])(C(\[H])=C(/[H])C1=C(C([H])=C(N=C1C([H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C(F)C([H])=C1[H])C([H])([H])[C@@]([H])(O[H])C([H])([H])C([O-])=O [H]N([H])C(=NC([H])([H])C([H])([H])C([H])([H])[C@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])C([H])([H])N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)[C@]([H])(N([H])C(=O)[C@@]([H])(N([H])C(=O)C([H])([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])N=C(N([H])[H])N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])C([H])([H])C1=C([H])N([H])C([H])=N1)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C(=O)N([H])[C@]([H])(C(=O)N([H])[H])C([H])([H])C1=C([H])N([H])C2=C1C([H])=C([H])C([H])=C2[H])N([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C(=O)C1=C(O[C@@]2([H])O[C@@]([H])(C([H])([H])OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]([H])(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@@]([H])(OC([H])([H])C3=C([H])C([H])=C([H])C([H])=C3[H])[C@]2([H])S1(=O)=O)C1=C([H])C([H])=C([H])C([H])=C1[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C([H])S1)C([H])([H])N([H])C(=O)C1=C([H])C2=C(C([H])=C1[H])C([H])([H])N(C2=O)C([H])([H])C([H])([H])C1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H] [H]C1=C([H])C(=C([H])C(C(=O)OC([H])([H])[H])=C1C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)C([H])([H])[H] [H]C#CC1=C([H])C2=C([H])C([H])=C([H])C(C(=O)N([H])[H])=C2N=C1[H] [H]N(C1=C(OC([H])([H])[H])N=C(C2=C(Cl)C([H])=C(Cl)C([H])=C2[H])C(=N1)C([H])([H])C([H])([H])[H])C([H])(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])[H] [H]N([H])C1=C([H])C([H])=C(C(OC([H])([H])[H])=C1[H])C1=NC2=C(C(=NS2)C2=C(F)C([H])=C([H])C([H])=C2[H])C(=O)N1[H] [H]OC([H])([H])C(N([H])C([H])([H])C(=O)N1[C@]([H])(C#N)C([H])([H])C([H])([H])[C@]1([H])C#N)(C([H])([H])[H])C([H])([H])[H] COC1=CC=C(N2C=C(N=C12)C(F)(F)F)C1=NN(CCCCOC2=C(F)C(F)=C(C=C2)C2=NNC(=O)C2(C)C)C(=O)C1(C)C [H]N(C1=C([H])C([H])=C([H])C(OC([H])([H])C2=C([H])N(N=N2)C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2[H])=C1[H])S(=O)(=O)C(\[H])=C(/[H])C1=C([H])C(Cl)=C([H])C([H])=C1[H] [H]OS(=O)(=O)C([H])([H])[C@@]([H])(N([H])[H])C([H])([H])C([H])([H])C(=O)N([H])C1=C([H])C([H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H] [H]N([H])C1=NC([H])=C([H])N2C(=NC(=C12)C1=C([H])C(N([H])[H])=C(OC2=C([H])C([H])=C([H])C([H])=C2[H])C([H])=C1[H])C1([H])C([H])([H])C([H])([H])C1([H])[H] [H]OC(=O)[C@]([H])(N([H])C(=O)OC([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H])C([H])([H])C([H])([H])C(=O)N1C([H])([H])C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])[C@@]1([H])C(=O)O[H] [H]N(C1=NN=C(O1)C1=C(N=C([H])N1C([H])([H])[H])N([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] [H]N1C(=O)N(C2=NC(=NC([H])=C12)N1C([H])=NC2=C1C([H])=C(C#N)C([H])=C2[H])C([H])([H])C1=C(F)C(F)=C([H])C([H])=C1[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])OC1=C([H])C2=C(C([H])=C1[H])C(=O)C1=C2N=NC(=C1[H])C([H])([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])[C@@]([H])(N1C(=O)C2=C(C([H])=C([H])C([H])=C2[H])C1=O)C(=O)N1C([H])([H])C([H])([H])C(=C2C3=NC([H])=C([H])C([H])=C3C([H])([H])C([H])([H])C3=C2C([H])=C([H])C(Cl)=C3[H])C([H])([H])C1([H])[H] [H]OC1=C([H])C([H])=C(C([H])=C1O[H])C1=C([H])C([H])=C2C(=NN([H])C2=C1[H])N([H])C(=O)C([H])([H])C([H])([H])C([H])([H])[H] [H]OC(=O)[C@@]([H])(N([H])S(=O)(=O)C1=C([H])C([H])=C(C([H])=C1[H])C1=C([H])C([H])=C(N([H])C(=O)C2=C(C3=C(O2)C([H])=C([H])C([H])=C3OC([H])([H])[H])C([H])([H])[H])C([H])=C1[H])C([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])N1C2=C(C([H])=C([H])C([H])=C2[H])C([H])([H])C([H])([H])C2=C1C([H])=C([H])C([H])=C2[H] [H]OC1=C2C(=O)\C(OC2=C(C(O[H])=C1[H])C1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1Cl [H]N([H])C1=C([H])C([H])=C([H])C([H])=C1N([H])C(=O)C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N([H])C1=NC([H])=C([H])C(=N1)C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1[H] [H]OC(=O)C1=C([H])C([H])=C([H])C(=N1)C(=O)N([H])C1=C(Br)C([H])=C(C([H])=C1[H])S(=O)(=O)N([H])[H] [H]C1=C2C3=C(N=C(C([H])=C3N(C([H])([H])C2([H])[H])C([H])(C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])[H])N1C([H])([H])C([H])([H])C([H])([H])OC([H])(C([H])([H])[H])C([H])([H])[H] [H]N(C(=O)[C@]([H])(OC1=C(C([H])=C(C([H])=C1C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])N1C2=C(N=C1C([H])([H])C([H])([H])[H])C(=C([H])C(=N2)C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H])C1=C([H])C2=C(OC([H])([H])O2)C([H])=C1[H])S(=O)(=O)C([H])(C([H])([H])[H])C([H])([H])[H] CCCC(=O)NC1=NNC2=CC(Cl)=C(C=C12)C1=CC=C(C=C1)N(O)=O [H]N1C2=NN(C([H])=C2C(=NC2=C1C([H])=C([H])C([H])=C2Cl)N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])C([H])([H])[H] [H]N([H])C1=C([H])C(=NC(OC([H])([H])C([H])([H])[H])=C1C#N)N([H])C(=O)C([H])([H])C1=C([H])C(OC([H])([H])[H])=C(N([H])C(=O)C([H])([H])[H])C([H])=C1OC([H])([H])[H] [H]N([H])[C@@]([H])(C(=O)N([H])[C@]([H])(C1=C([H])C(=C([H])C([H])=C1N1C([H])([H])C([H])([H])N(C(=O)[C@]([H])(N2C(=O)C([H])([H])C([H])([H])C2([H])[H])C([H])([H])C2=C([H])C([H])=C(Cl)C([H])=C2Cl)C([H])([H])C1([H])[H])C([H])([H])[H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C([H])C([H])=C(C([H])=C1[H])C1=C(N(C(=O)C2=C([H])C([H])=C(OC([H])([H])[H])C([H])=C12)C([H])([H])[H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H] [H]N=C(N([H])[H])C1=C([H])C(=C([H])C([H])=C1[H])C1=NO[C@@](C(=O)N([H])C2=C([H])C([H])=C(C([H])=C2[H])C2=C([H])C([H])=C([H])C([H])=C2[H])(C([H])([H])C(=O)OC([H])([H])[H])C1([H])[H] [H]N(C(=O)C1=C([H])N(C2=C(C([H])=C(C([H])=C2[H])S(=O)(=O)N2C([H])([H])C([H])([H])OC([H])([H])C2([H])[H])C1=O)C([H])([H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C(Cl)C([H])=C1[H] [H]N(C1=NC(=NN1[H])C([H])(C([H])([H])[H])C([H])([H])[H])S(=O)(=O)C1=C(N([H])[C@]2([H])C([H])([H])[C@@]3([H])C([H])([H])C([H])([H])[C@]2([H])C3([H])[H])C([H])=C([H])N=C1[H] [H]OC1=C([H])C([H])=C(\C([H])=C(/[H])C(=O)N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N2C([H])([H])C([H])([H])C([H])(C3=C([H])N([H])C4=C([H])C([H])=C([H])C([H])=C34)C([H])([H])C2([H])[H])C([H])=C1[H] [H]C1=NC2=C(OC(=O)C3=C([H])C(=C([H])C([H])=C3[H])S(=O)(=O)N3C([H])([H])C([H])([H])C([H])([H])C3([H])[H])C([H])=C([H])C([H])=C2C([H])=C1[H] [H]C1=NC(=C([H])C([H])=C1C(F)(F)F)N1C([H])([H])C([H])([H])C([H])(C(=O)N2C([H])([H])[C@]([H])(C3=C([H])C([H])=C(Cl)C([H])=C3[H])[C@@](C([H])([H])[H])(C([H])([H])OC3=NC([H])=C(Cl)C([H])=C3[H])C2([H])[H])C([H])([H])C1([H])[H] [H]N1C([H])=NC(=C1[H])C([H])([H])C([H])([H])C#CC([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=C(C2=C1C(=C1N([H])N=C(C1=C2[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] [H]C1=C(N2N=C(OC([H])([H])[H])C(N(C([H])([H])C([H])([H])[H])C3([H])C([H])([H])C([H])([H])C([H])([H])C3([H])[H])=C2S1)C1=C(OC([H])([H])[H])C([H])=C(C([H])=C1OC([H])([H])[H])C([H])([H])OC([H])([H])[H] CC1=C(C=CC=C1Cl)C(=O)N1CCC[C@@H](C1)C1=NN=C(O1)C1=CC=CC=C1 [H]N(C([H])([H])C([H])([H])C1=C(N([H])C2=C1C([H])=C(C([H])=C2[H])C(=O)N(C([H])([H])C([H])([H])[H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])C1=C([H])C(=C([H])C(=C1[H])C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1=C([H])C([H])=NC([H])=C1[H] [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])N([H])C(=O)C([H])([H])OC1=C([H])C([H])=C(C([H])=C1[H])C1=NC2=C(N1[H])N(C(=O)N(C2=O)C([H])([H])C([H])([H])C([H])([H])[H])C([H])([H])C([H])([H])C([H])([H])[H] [H]N1N=NC(=N1)C1=C(C([H])=C([H])C([H])=C1[H])C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])N1C(=O)C2=C([H])C(=C([H])C([H])=C2N=C1C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])[C@@]1(ON=C(C(=O)OC([H])([H])C([H])([H])[H])C1([H])[H])C([H])([H])[H]